Ready to drink electrolyte solution

Abstract

The disclosure generally relates to ready to drink electrolyte solution. In particular the disclosure relates to a ready to drink electrolyte solution comprising isomaltulose, glucose, sodium ions, chromium ions and water; wherein the glucose concentration is greater than or equal to 0.9g / 100ml, and wherein the theoretical glycemic index of the solution is equal to or less than 55. The disclosure also relates to a method of manufacturing said ready to drink electrolyte solution. The disclosure also relates to a method of rehydrating a patient suffering from cancer, diabetes, acute or chronic illness, or a gastrointestinal disorder by using said ready to drink electrolyte solution.

Description

[0001] TITLE

[0002] Ready to drink electrolyte solution

[0003] FIELD

[0004] The disclosure generally relates to ready to drink electrolyte solutions. In particular, the disclosure relates to a ready to drink electrolyte solution with a low glycemic index.

[0005] The disclosure also relates to a method of manufacturing said ready to drink electrolyte solution. The disclosure also relates to a method of rehydrating a patient suffering from cancer, diabetes, acute or chronic illness, or a gastrointestinal disorder by using said ready to drink electrolyte solution.

[0006] BACKGROUND

[0007] The human body has water as the most significant single component. Its composition is essential for metabolic integrity and physiological functions. Maintaining an optimal water / fluid balance, guided by critical concepts of total body water and solute levels, is crucial for overall health.

[0008] Dehydration results from an imbalance between fluid output and intake, causing insufficient water and electrolyte imbalances. Factors like ageing, inadequate / excessive fluid intake, alcohol consumption, elevated ambient temperature, diabetes, vomiting, diarrhea, cancer, radiation treatment, chemotherapy treatment, and diuretic use can disrupt electrolyte and water balance at different life stages.

[0009] Even mild dehydration can impair cognitive function, affecting psychomotor and memory skills. Older individuals facing acute or chronic dehydration may experience cognitive decline, reduced bodily function (for example renal or gastrointestinal), increased fall risk, and requirement for prolonged hospital stays. Inadequate fluid intake, a key contributor to kidney stone formation, causes concentrated urine and mineral supersaturation. It also heightens the risk of urinary tract infections, leading to complications like confusion, falls, and kidney issues as mentioned above while exacerbating gastrointestinal problems in individuals with Gastroesophageal reflux disease (GERD) by delaying gastric emptying.

[0010] Non-diarrheal clinical conditions like fever (associated with flu / viral illnesses / dengue / malaria / typhoid), nausea, vomiting, and infections (including respiratory tract infections and urinary tract infections) are commonly associated with dehydration, significantly impacting senior citizens and children. This can lead to fluid, electrolyte, and energy imbalances, causing general weakness. Proper hydration is crucial in managing these conditions. In addition, firefighters, athletes, and others at risk of heat-related illnesses are also likely to encounter dehydration.

[0011] Fluid imbalance is commonly addressed by hydration. Hydration can be active, for example through sodium glucose pump (SGLT1) activation (faster hydration rate), or passive, for example through passive absorption of water (relatively slower hydration rate).

[0012] Diabetes is a recognized risk factor for dehydration. These increased risks of dehydration in diabetic individuals are due to increase glucose secretion in urine, osmotic diuresis caused increased urination, use of anti-hyperglycemic drugs, and insufficient fluid intake. Dehydration in diabetic individuals may cause dizziness, headache, tiredness, dry eyes, dry mouth, increased thirst, dark yellow urine, diabetic ketoacidosis, confusion, low blood pressure and weak pulse, and hyperosmolar hyperglycemic state. Adequate hydration may help prevent these associated complications.

[0013] Energy imbalances causing general weakness may be addressed by intake of carbohydrate such as glucose (or dextrose). Glycemic index, or GI, of glucose is equal to 100; there is a quick release of glucose in the blood stream shortly after consumption. Other carbohydrates with lower GI such as isomaltulose (GI = 32) provide a more sustained release of glucose allowing for a more gradual increase in glucose concentration in the blood stream as well as a more gradual increase of insulin in comparison to high GI carbohydrates. This slower and more sustained release of glucose is desirable for individuals seeking sustained energy release without the fluctuations associated with quick release (high GI) carbohydrates.

[0014] There is a need to develop new ready to drink electrolyte solutions that would have the combined benefit of a quick and sustained release of glucose in the blood stream. These new ready to drink electrolyte solutions should provide not only the water restoration the patients need but also a quick and sustained supply in energy to help the recovery, or simply improve the daily life quality, of patients suffering from gastrointestinal disorders, acute or chronic illness, or more severe conditions such as diabetes and cancer. In addition, these new ready to drink electrolyte solutions should have a sodium content compatible with the activation of the sodium-glucose transport protein (SGLT1) for an active hydration of the patients but simultaneously should be adequate for elderly patients that may suffer from hypertension and should have a controlled intake of salts. It would be desirable for these new ready to drink electrolyte solutions to have an amount of dextrose sufficient for the quick release of energy and the active hydration through SGLT 1 proteins activation, but also to have an amount of dextrose compatible with patients suffering from medical conditions related to glucose metabolism such as diabetes. Furthermore, some ready to drink electrolyte solutions have an unpleasant taste, for example a metallic taste; this may reduce the willingness of the patient to drink the solution despite all the health benefits.

[0015] The present disclosure proposes to address the above-described unmet needs by providing a ready to drink electrolyte solutions allowing for a controlled glycemia and a controlled intake of salts, while still providing a pleasant taste. The ready to drink electrolyte solutions proposed by the present disclosure address the general weakness caused by fluid, electrolyte, and energy imbalances.

[0016] SUMMARY

[0017] One aspect of the disclosure pertains to a ready to drink electrolyte solution comprising: isomaltulose, glucose, sodium ions present in the form of at least one sodium salt, chromium ions present in the form of at least one chromium salt; and water; wherein the glucose concentration is greater than or equal to 0.9g / 100ml, and wherein the theoretical glycemic index of the solution is equal to or less than 55.

[0018] This aspect may be combined with a variety of embodiments, in any combination. Thus, in some embodiments the concentration of isomaltulose is greater than or equal to O.lg / lOOmL. In some embodiments the concentration of glucose is greater than or equal to Ig / lOOmL. In some embodiments the molarity of the sodium ions is less than 75mmol / L. In some embodiments the molarity of glucose is greater than or equal to the molarity of sodium ions. In some embodiments the Osmolarity of the solution is less than or equal to 450mOsm / L. In some embodiments the chromium salt is chromium picolinate. In some embodiments the chromium ions are present in the form of chromium picolinate and the concentration of chromium picolinate is less than or equal to 240pg / 100mL. In some embodiments the theoretical glycemic index of the solution is less than 52. In some embodiments the solution has a calorie content less than or equal to 35kcal per 100ml. In some embodiments the solution further comprises metallic ions selected from: calcium, iron, zinc, or combinations thereof. In some embodiments the solution further comprises at least one vitamin.

[0019] Another aspect of the disclosure pertains to a ready to drink electrolyte solution comprising: isomaltulose at a concentration from 1g to lOg / lOOmL, glucose at a concentration from 0.9g to 2g / 100mL, sodium ions at a molarity from 35mmol / L to 65mmol / L, and a chromium salt in the form of chromium picolinate at a concentration from l Opg / I OOmL to l 2O,ug / IOOmL, and wherein the theoretical glycemic index of the solution is equal to or less than 50.

[0020] Another aspect of the disclosure pertains to a method for the manufacture of a ready to drink electrolyte solution according to any of the embodiments described above, comprising: dissolving isomaltulose, dextrose and at least one sodium salt in water, to obtain a first solution; dissolving chromium salt in water at a temperature suitable to dissolve the chromium salt to obtain a chromium salt solution; and combining the chromium salt solution and the first solution.

[0021] Another aspect of the disclosure pertains to a method of rehydrating a patient suffering from dehydration, the method comprising administering the ready to drink electrolyte solution according to any of the embodiments described above to a patient suffering from dehydration. Another aspect of the disclosure pertains to a method of rehydrating a patient suffering from cancer or diabetes, the method comprising administering the ready to drink electrolyte solution according to any of the embodiments described above to a patient suffering from cancer or diabetes. Another aspect of the disclosure pertains to a method of rehydrating an elderly patient, the method comprising administering the ready to drink electrolyte solution according to any of the embodiments described above to an elderly patient. Another aspect of the disclosure pertains to a method of rehydrating and providing an energy supplementation to a patient suffering from acute or chronic illness, the method comprising administering the ready to drink electrolyte solution according to any of the embodiments described above to a patient suffering from acute or chronic illness and needing an energy supplementation. Another aspect of the disclosure pertains to a method of rehydrating a patient suffering from a gastrointestinal disorder, such as irritable bowel syndrome or inflammatory bowel disease, the method comprising administering the ready to drink electrolyte solution according to any of the embodiments described above to a patient suffering from a gastrointestinal disorder.

[0022] DETAILED DESCRIPTION

[0023] To provide a more concise description, some of the quantitative expressions given herein are not qualified with the term “about”. It is understood that whether the term “about” is used explicitly or not, every quantity given herein is meant to refer to the actual given value, and it is also meant to refer to the approximation to such given value that would reasonably be inferred based on the ordinary skill in the art, including approximations due to the experimental and / or measurement conditions for such given value. The general convention in the scientific and technical literature is applied: the last decimal place of a numerical value indicates its degree of accuracy. Where no other error margins are given, the maximum margin is ascertained by applying the rounding-off convention to the last decimal place, for example for a value of 3.5 g / lOOmL, the error margin is 3.45-3.54 g / lOOmL.

[0024] One aspect of the disclosure pertains to a ready to drink electrolyte solution comprising: isomaltulose, glucose, sodium ions present in the form of at least one sodium salt, chromium ions present in the form of at least one chromium salt; and water wherein the glucose concentration is greater than or equal to 0.9g / 100ml, and wherein the theoretical glycemic index of the solution is equal to or less than 55.

[0025] By “theoretical glycemic index” it is meant a glycemic index (GI) obtained by a mathematical model. For example, the calculation of the theoretical GI may be performed according to the methodology disclosed in: Food and Agriculture Organization report Carbohydrates in Human Nutrition: Report of a Joint FAO / WHO Expert Consultation. Rome, 1997; FAO: Rome, Italy, 1998. According to this methodology, a good approximation of the GI of the ready to drink electrolyte solution may be obtained.

[0026] Theoretical glycemic index may be calculated as follow: for each carbohydrate source, carbohydrate GI is multiplied by carbohydrate respective amount (in gram), the obtained values are added, and the result is divided by the sum of the carbohydrate sources amounts. For the present disclosure at least two carbohydrate sources are present: glucose and isomaltulose. If no further carbohydrate sources are present the theoretical glycemic index may thus be calculated as:

[0027] ((GI isomaltulose * mass of isomaltulose) + (GI glucose * mass of glucose)) / (mass of isomaltulose + mass of glucose) wherein the GI of isomaltulose is equal to 32, and the GI of glucose is equal to 100.

[0028] Theoretical glycemic index may differ from in vivo GI measurement. In vivo GI value is difficult to predict because it can be influenced by the subject metabolism, particularly carbohydrate metabolism; the subject lifestyle, genetic factors and body size. In vivo GI measurements must be performed over a panel of individuals to obtain an average value, for example using the standard ISO method (ISO / 26642:2010). Foods (including liquid solutions) having an in vivo GI value equal or less than 55 are generally considered to be low-GI foods. Low-GI foods (including liquid solutions) are particularly desirable for patients suffering from diabetes.

[0029] In another aspect, the disclosure may pertain to a ready to drink electrolyte solution comprising: isomaltulose, glucose, sodium ions present in the form of at least one sodium salt, chromium ions present in the form of at least one chromium salt; and water wherein the glucose concentration is greater than or equal to 0.9g / 100ml, and wherein the in vivo glycemic index of the solution is equal to or less than 55.

[0030] In one or more embodiment of the ready to drink electrolyte solution, the theoretical glycemic index of the solution is equal to or less than 55, and the in vivo glycemic index of the solution is equal to or less than 55.

[0031] In one or more embodiment of the ready to drink electrolyte solution, the concentration of isomaltulose may be greater than or equal to 0. Ig / lOOmL, preferably greater than or equal to Ig / lOOmL, more preferably greater than or equal to 4g / 100mL.

[0032] Alternatively, or in addition, the ready to drink electrolyte solution may have a concentration of isomaltulose less than or equal to 15g / 100mL, preferably less than or equal to lOg / lOOmL, more preferably less than or equal to 6g / 100mL.

[0033] In one or more embodiment of the ready to drink electrolyte solution, the concentration of isomaltulose may be from 0.1g to 15g / 100mL, preferably 0.1g to lOg / lOOmL, preferably from 0.1g to 6g / 100mL, preferably from 1g to 15g / 100mL, preferably from 1g to lOg / lOOmL, preferably from 1g to 6g / 100mL, preferably from 4g to 15g / 100mL, preferably from 4g to lOg / lOOmL, preferably from 4g to 6g / 100mL.

[0034] It is advantageous for the ready to drink electrolyte solution according to the present disclosure to contain isomaltulose because the relatively slow nature of its disaccharide digestion allows for a sustained release of glucose in the blood stream. In one or more embodiment of the ready to drink electrolyte solution, the concentration of glucose may be greater than or equal to Ig / lOOmL, preferably greater than or equal to 1.2g / 100mL, more preferably greater than or equal to 1.4g / 100mL.

[0035] Alternatively, or in addition, the ready to drink electrolyte solution may have a concentration of glucose less than or equal to 3g / 100mL, preferably less than or equal to 2.5g / 100mL, preferably less than or equal to 2g / 100mL, more preferably less than or equal to 1.5g / 100mL.

[0036] By “glucose”, and when considering the concentrations provided in the present disclosure, it is meant anhydrous glucose. However, a person skilled in the art would understand that when formulating the ready to drink electrolyte solution alternative sources of glucose may be used such as hydrated glucose, for example monohydrate glucose, or dextrose (anhydrous or hydrated). When selecting an alternative to anhydrous glucose, concentration should be adapted according to the molecular weight of the selected alternative.

[0037] In one or more embodiment of the ready to drink electrolyte solution, the concentration of glucose may be from 0.9g to 3g / 100mL, preferably from 0.9g to 2.5g / 100mL, preferably from 0.9g to 2g / 100mL, preferably from 0.9g to 1.5g / 100mL, preferably from 1g to 3g / 100mL, preferably from 1g to 2.5g / 100mL, preferably from 1g to 2g / 100mL, more preferably from 1g to 1.5g / 100mL, preferably from 1.2g to 3g / 100mL, preferably from 1.2g to 2.5g / 100mL, preferably from 1.2g to 2g / 100mL, preferably from 1.2g to 1.5g / 100mL, preferably from 1.4g to 3g / 100mL, preferably from 1.4g to 2.5g / 100mL, preferably from 1.4g to 2g / 100mL, preferably from 1.4g to 1.5g / 100mL.

[0038] It is advantageous for the ready to drink electrolyte solution according to the present disclosure to contain a high (i.e. greater than or equal to 0.9g / 100mL) amount of glucose because the ready to drink electrolyte solution will then provide an energy boost to the patient in need thereof. Glucose may also increase the palatability of the ready to drink electrolyte solution. Further, the presence of glucose and sodium ions trigger the sodium glucose pump (SGLT1) in the small intestine and promote active water absorption, which is highly desirable for a patient suffering from dehydration.

[0039] In one or more embodiment of the ready to drink electrolyte solution, the molarity of the sodium ions may be less than 75mmol / L; preferably less than or equal to 65mmol / L, more preferably less than or equal to 55mmol / L. In other words, the molarity of sodium ions disclosed above would correspond to a concentration in sodium ions less than 172.5mg / 100mL; preferably less than or equal to 149.5mg / 100mL, more preferably less than or equal to 126.5mg / 100mL.

[0040] In one or more embodiment of the ready to drink electrolyte solution, the molarity of the sodium ions may be greater than or equal to 25mmol / L; preferably greater than or equal to 35mmol / L, more preferably greater than or equal to 45mmol / L.

[0041] In other words, the molarity of sodium ions disclosed above would correspond to a concentration in sodium ions greater than or equal to 57.5mg / 100mL; preferably greater than or equal to 80.5mg / 100mL, more preferably greater than or equal to 103.5mg / 100mL.

[0042] Preferred sources of sodium ions according to the present disclosure may be sodium salts such as sodium chloride, sodium citrate (for example trisodium citrate dihydrate), or a combination thereof.

[0043] In one or more embodiment of the ready to drink electrolyte solution, the molarity of the sodium ions may be from 25mmol to 75mmol / L, preferably from 35mmol to 75mmol / L, preferably from 45mmol to 75mmol / L, preferably from 25mmol to 65mmol / L, preferably from 35mmol to 65mmol / L, preferably from 45mmol to 65mmol / L, preferably 25mmol to 55mmol / L, preferably from 35mmol to 55mmol / L, preferably from 45mmol to 55mmol / L.

[0044] In other words, the ranges of molarity of sodium ions disclosed above would correspond to a concentration in sodium ions from 57.5mg / 100mL to 172.5mg / 100mL, preferably from 80.5mg / 100mL to 172.5mg / 100mL, preferably from 103.5mg / 100mL to 172.5mg / lOOmL, preferably from 57.5mg / 100mL to 149.5mg / 100mL, preferably from 80.5mg / 100mL to 149.5mg / lOOmL, preferably from 103.5mg / 100mL to 149.5mg / lOOmL, preferably from 57.5mg / 100mL to 126.5mg / 100mL, preferably from 80.5mg / 100mL to 126.5mg / lOOmL, preferably from 103.5mg / 100mL to 126.5mg / lOOmL.

[0045] It is advantageous for the ready to drink electrolyte solution according to the present disclosure to contain a low (i.e. less than 75mmol / L) amount of sodium because the ready to drink electrolyte solution would be more suitable for a patient monitoring their salt intake such as a patient suffering from hypertension. However, a minimal amount of sodium is required as it is known that the presence of glucose and sodium ions trigger the sodium glucose pump (SGLT1) in the small intestine and promote active water absorption, which is highly desirable for a patient suffering from dehydration.

[0046] In one or more embodiment of the ready to drink electrolyte solution, the molarity of glucose may be greater than or equal to the molarity of sodium ions.

[0047] It is advantageous to have both sodium ions and glucose present simultaneously in the ready to drink electrolyte solution as they can activate the sodium-glucose transport proteins (SGLT1) in the intestine and enhance water uptake which is very desirable for a patient suffering from dehydration. Preferably, the molarity of glucose should be at least equal to the molarity of sodium ions to have an optimal activation of the sodium-glucose transport proteins.

[0048] In one or more embodiment of the ready to drink electrolyte solution, the Osmolarity of the solution may be less than or equal to 450mOsm / L, preferably less than or equal to 400mOsm / L.

[0049] In one or more embodiment of the ready to drink electrolyte solution the chromium salt may be chromium picolinate.

[0050] In other words, the preferred form of chromium ions in the ready to drink electrolyte solution may be chromium picolinate.

[0051] In one or more embodiment of the ready to drink electrolyte solution, the chromium salt may be present in a quantity sufficient to allow for a molarity of chromium ions less than or equal to 6pmol / L, preferably less than or equal to 3pmol / L, preferably less than or equal to 1.5pmol / L.

[0052] Alternatively, or in addition, the ready to drink electrolyte solution may have a chromium salt present in a quantity sufficient to allow for a molarity of chromium ions greater than or equal to 0.01 pmol / L, preferably greater than or equal to 0. 1 umol / L, preferably greater than or equal to Ipmol / L.

[0053] In one or more embodiment of the ready to drink electrolyte solution, the chromium salt may be present in a quantity sufficient to allow for a molarity of chromium ions from 0.0 I pmol / L to 6, umol / L, preferably from 0.1 , umol / L to 6umol / L. preferably from I , u mol / L to 6p mol / L, preferably from O.Olpmol / L to 3pmol / L, preferably from O.lpmol / L to 3 umol / L. preferably from Ipmol / L to 3pmol / L, preferably from O.Olpmol / L to 1 .5, umol / L, preferably from 0. Ipmol / L to 1 .5, umol / L, preferably from Ipmol / L to 1 .5, u mol / L. In one or more embodiment of the ready to drink electrolyte solution, the chromium ions may be present in the form of chromium picolinate and the concentration of chromium picolinate may be less than or equal to 400pg / 100mL, preferably less than or equal to 240pg / lOOmL, preferably less than or equal to 120|ig / 100mL, preferably less than or equal to 70|ig / 100mL. Alternatively, or in addition, the ready to drink electrolyte solution may have the chromium ions present in the form of chromium picolinate and the concentration of chromium picolinate may be greater than or equal to 1 pg / lOOmL, preferably greater than or equal to ICpg / lOOmL, preferably greater than or equal to 40pg / lOOmL.

[0054] In one or more embodiment of the ready to drink electrolyte solution, the chromium ions may be present in the form of chromium picolinate and the concentration of chromium picolinate may be from I pg / lOOmL to 240pg / 100mL, preferably from lOpg / lOOmL to 240pg / 100mL, preferably from 40pg / lOOmL to 240pg / l OOmL, preferably from Ipg / lOOmL to 120pg / 100mL, preferably from 1 Op g / lOOmL to 120pg / lOOmL, preferably from 40pg / 100mL to 120pg / 100mL, preferably from Ipg / lOOmL to 70pg / 100mL, preferably from lOpg / IOOmL to 70pg / 100mL, preferably from 40pg / 100mL to 70pg / 100mL.

[0055] In one or more embodiment of the ready to drink electrolyte solution, the theoretical glycemic index of the solution may be less than 52, preferably less than 50, more preferably less than or equal to 48.

[0056] Alternatively, or in addition, the ready to drink electrolyte solution may have a theoretical glycemic index of the solution greater than or equal to 30, preferably greater than or equal to 35, preferably greater than or equal to 40.

[0057] In one or more embodiment of the ready to drink electrolyte solution, the solution may have a calorie content less than or equal to 35kcal per 100ml, preferably less than or equal to 30kcal per 100ml.

[0058] Alternatively, or in addition, the ready to drink electrolyte solution may have a calorie content greater than or equal to 15kcal per 100ml, preferably greater than or equal to 20kcal per 100ml. In one or more embodiment of the ready to drink electrolyte solution, the solution may have a calorie content from 15kcal to 35kcal per 100ml, preferably from 20kcal to 30kcal per 100ml, preferably from 20kcal to 25kcal per 100ml. In one or more embodiment of the ready to drink electrolyte solution, the solution may have a glycemic load, per 200ml serving, equal or less than 10, preferably equal or less than 9, preferably equal or less than 8, preferably equal or less than 7.

[0059] The Glycemic Load of the ready to drink electrolyte solution is calculated by multiplying the amount of available carbohydrate per serving size by its in vivo GI value and then dividing by 100.

[0060] A glycemic load per serving equal or below 10 is associated with low glycemic load food (or liquid solution). Low glycemic load foods (or liquid solutions) are particularly desirable for patients suffering from diabetes.

[0061] In one or more embodiment of the ready to drink electrolyte solution, the solution may further comprise metallic ions selected from: calcium, iron, zinc, or combinations thereof.

[0062] The presence of metallic ions such as calcium, iron, zinc or their combination, may be advantageous for the ready to drink electrolyte solution because these metallic ions are important micronutrients and may help promote the overall health and immune system function of the patient.

[0063] In one or more embodiment of the ready to drink electrolyte solution, the solution may further comprise at least one vitamin, preferably selected from vitamin B and vitamin D, or combinations thereof.

[0064] The presence of vitamins such as vitamin B and vitamin D or their combination, may be advantageous for the ready to drink electrolyte solution because these vitamins are important micronutrients and may help promote the health and immune system of the patient.

[0065] In one or more embodiment of the ready to drink electrolyte solution, the preferred vitamins may be vitamin B12, vitamin D2, vitamin D3 or their combinations. It is preferable that D vitamins should be water dispersible or water miscible.

[0066] In one or more embodiment the ready to drink electrolyte solution may contain juice such as fruit juice, preferably fruit juice concentrate.

[0067] Ready to drink electrolyte solutions may have an unpleasant taste, for example due to a high salt content. It is desirable to improve their palatability with an addition of flavors, sweeteners, or perfumes. It may be advantageous for the ready to drink electrolyte solution according to the present disclosure to contain juice because it could enhance the sensorial attributes (palatability) of the ready to drink electrolyte solution, making it more pleasurable for the patient to drink and therefore increasing the probability of the patient to adhere to the treatment.

[0068] Examples of preferred juices include apple, orange, lemon, pomegranate, mango, litchi, berries or mixed fruit.

[0069] In a preferred embodiment, the ready to drink electrolyte solution according to the present disclosure may comprise: isomaltulose, at a concentration from 1g to lOg / lOOmL, glucose, at a concentration from 0.9g to 2g / 100mL, sodium ions, at a molarity from 35mmol / L to 65mmol / L, and chromium salt in the form of chromium picolinate at a concentration from I Opg / I OOmL to 120pg / 100mL, wherein the theoretical glycemic index of the solution may be equal to or less than 50.

[0070] In one or more embodiment, the ready to drink electrolyte solution may comprise: isomaltulose, at a concentration ranging from 4g to 6g / 100mL, glucose, at a concentration ranging from 1g to 1.5g / 100mL, sodium ions, at a molarity ranging from 45mmol / L to 55mmol / L, and chromium salt in the form of chromium picolinate at a concentration from 40pg / l OOmL to 70pg / 100mL, wherein the theoretical glycemic index of the solution is ranging from 40 to 50.

[0071] In another aspect the disclosure may pertain to a method for the manufacture of the ready to drink electrolyte solution according to the disclosure, comprising: dissolving isomaltulose, dextrose and at least one sodium salt in water, to obtain a first solution, dissolving chromium salt in water at a temperature suitable to dissolve the chromium salt, for example from 75°C to 95°C, to obtain a chromium salt solution, optionally cooling the chromium salt solution, for example to room temperature, and combining the chromium salt solution and the first solution.

[0072] Alternatively, the method for the manufacture of the ready to drink electrolyte solution according to the disclosure may comprise: dissolving chromium salt in water at a temperature suitable to dissolve the chromium salt, for example from 75 °C to 95 °C, to obtain a chromium salt solution, optionally cooling the chromium salt solution to room temperature dissolving isomaltulose, dextrose and at least one sodium salt in water, to the chromium salt solution.

[0073] The method for the manufacture of the ready to drink electrolyte solution according to the disclosure may be a continuous process or a batch process.

[0074] In another aspect the disclosure may pertain to a method of rehydrating a patient suffering from dehydration, the method comprising administering the ready to drink electrolyte solution according to any of the embodiments described above to a patient suffering from dehydration. In other words, the disclosure may pertain to the use of the ready to drink electrolyte solution as disclosed above for the manufacture of a rehydration solution for the treatment of patients suffering from dehydration.

[0075] The disclosure may pertain to the ready to drink electrolyte solution as disclosed above for use in the rehydration of patients suffering from dehydration.

[0076] In another aspect the disclosure may pertain to a method of rehydrating a patient suffering from cancer or diabetes, the method comprising administering the ready to drink electrolyte solution according to any of the embodiments described above to a patient suffering from cancer or diabetes.

[0077] In other words, the disclosure may pertain to the use of the ready to drink electrolyte solution as disclosed above for the manufacture of a rehydration solution for the treatment of patients suffering from cancer or diabetes.

[0078] The disclosure may pertain to the ready to drink electrolyte solution as disclosed above for use in the rehydration of patients suffering from cancer or diabetes.

[0079] In another aspect the disclosure may pertain to a method of rehydrating an elderly patient, the method comprising administering the ready to drink electrolyte solution according to any of the embodiments described above to an elderly patient, preferably to an elderly patient suffering from dehydration.

[0080] In other words, the disclosure may pertain to the use of the ready to drink electrolyte solution as disclosed above for the manufacture of a rehydration solution for the treatment of dehydration of elderly patients. The disclosure may pertain to the ready to drink electrolyte solution as disclosed above for use in the rehydration of elderly patients.

[0081] In another aspect the disclosure may pertain to a method of rehydrating and providing an energy supplementation to a patient suffering from acute or chronic illness, the method comprising administering the ready to drink electrolyte solution according to any of the embodiments described above to a patient suffering from acute or chronic illness and needing an energy supplementation.

[0082] In another aspect the disclosure may pertain to a method of rehydrating and providing an energy supplementation to patients suffering from acute or chronic illness with the ready to drink electrolyte solution as disclosed above, the method comprising administering the ready to drink electrolyte solution to a patient suffering from acute or chronic illness needing rehydration.

[0083] In other words, the disclosure may pertain to the use of the ready to drink electrolyte solution as disclosed above for the manufacture of a rehydration solution for the treatment of a patient suffering from an acute or chronic illness needing an energy supplementation.

[0084] The disclosure may pertain to the ready to drink electrolyte solution as disclosed above for use in the rehydration and energy supplementation of a patient suffering from an acute or chronic illness and needing an energy supplementation.

[0085] In another aspect the disclosure may pertain to a method of rehydrating a patient suffering from a gastrointestinal disorder, such as irritable bowel syndrome or inflammatory bowel disease, the method comprising administering the ready to drink electrolyte solution according to any of the embodiments described above to a patient suffering from a gastrointestinal disorder.

[0086] In other words, the disclosure may pertain to the use of the ready to drink electrolyte solution as disclosed above for the manufacture of a rehydration solution for the treatment of a patient suffering from a gastrointestinal disorder, such as irritable bowel syndrome or inflammatory bowel disease.

[0087] The disclosure may pertain to the ready to drink electrolyte solution as disclosed above for use in the rehydration of a patient suffering from a gastrointestinal disorder, such as irritable bowel syndrome or inflammatory bowel disease.

[0088] In another aspect the disclosure may pertain to a method of rehydrating a patient suffering from a gastrointestinal disorder, such as irritable bowel syndrome or inflammatory bowel disease, the method comprising administering the ready to drink electrolyte solution according to any of the embodiments described above to a patient suffering from a gastrointestinal disorder and needing rehydration.

[0089] In other words, the disclosure may pertain to the use of the ready to drink electrolyte solution as disclosed above for the manufacture of a rehydration solution for the treatment of a patient suffering from a gastrointestinal disorder, such as irritable bowel syndrome or inflammatory bowel disease, and needing rehydration.

[0090] The disclosure may pertain to the ready to drink electrolyte solution as disclosed above for use in the rehydration of a patient suffering from a gastrointestinal disorder, such as irritable bowel syndrome or inflammatory bowel disease and needing rehydration.

[0091] The present disclosure may be better understood through the following examples, which are exemplary in nature and not intended to be limiting to any specific combination of elements.

[0092] EXAMPLES

[0093] Trials 1 and 2 in table 1 are commercial products used as comparative examples. Trials 3 and 4 in table 1 are examples of ready to drink electrolyte solution formulations according to the present disclosure, with different glucose (dextrose monohydrate) content. Trial 4 includes fruit juice concentrate for improved palatability.

[0094] Table 1: examples of ready to drink electrolyte solution formulations.

[0095] Fruit juice concentrates used were either apple juice concentrate (minimal 68° BRIX) or lemon juice concentrate (minimal 53° BRIX).

[0096] For convenience in calculation, fruit juice concentrates’ impact on GI was deemed minimal and thus was not considered in the theoretical GI calculation. pH adjusters were selected from malic acid, ascorbic acid, citric acid.

[0097] Ingredients listed as sweetener were not carbohydrates and therefore did not contribute to the GI of the ready to drink electrolyte solution. Sweetener may be for example stevia, aspartame, monk fruit extract, sucralose, potassium acetasulfame, cyclamate, saccharin, or a polyol such as erythritol, xylitol or sorbitol. Preferably the sweetener may be stevia.

[0098] Formulation Procedure:

[0099] 1- Preparation of first solution:

[0100] Take 80% of the batch quantity of water in a clean mixing vessel. Dissolve dextrose monohydrate, sodium chloride, potassium chloride, isomaltose, pH adjuster and sweetener into the water. Continuously stir to achieve a clear solution. 2- Preparation of chromium salt solution:

[0101] Take less than or equal to 5% of the batch quantity of water in a separate clean mixing vessel. Dissolve chromium picolinate in hot water (75 °C to 95 °C) and gradually bring down the temperature to room temperature.

[0102] 3- Combining Solutions:

[0103] Add the chromium salt solution to the bulk solution prepared in step 1. Continue stirring to ensure uniform distribution. Optionally, add fruit juice concentrate.

[0104] 4- Flavor, Aroma & Coloring Addition:

[0105] Under continuous stirring, introduce the flavor, aroma & coloring agent into the solution.

[0106] 5- Final Adjustment:

[0107] Check the pH of the solution using a pH meter and if necessary, adjust the pH by adding pH adjuster. Make up the final volume of the solution before the filtration step.

[0108] 6- Filtration, quality and pasteurization:

[0109] Pass the solution through a security filtration system. Verify the clarity of the solution. Subject the solution to pasteurization using the appropriate setup. Carry out aseptic filling of the solution into containers such as laminated paper packages or bottles.

[0110] Ensure that all equipment and containers used are properly sanitized throughout the process to maintain the sterility of the final product.

Claims

1. CLAIMS1. A ready to drink electrolyte solution comprising: isomaltulose, glucose, sodium ions present in the form of at least one sodium salt, chromium ions present in the form of at least one chromium salt; and water wherein the glucose concentration is greater than or equal to 0.9g / 100ml, and wherein the theoretical glycemic index of the solution is equal to or less than 55.

2. The ready to drink electrolyte solution according to claim 1 , wherein the concentration of isomaltulose is greater than or equal to O.lg / lOOmL.

3. The ready to drink electrolyte solution according to claim 1, wherein the concentration of glucose is greater than or equal to Ig / lOOmL.

4. The ready to drink electrolyte solution according to claim 1 , wherein the molarity of sodium ions is less than 75mmol / L.

5. The ready to drink electrolyte solution according to claim 1, wherein the molarity of glucose is greater than or equal to the molarity of sodium ions.

6. The ready to drink electrolyte solution according to claim 1 , wherein the Osmolarity of the solution is less than or equal to 450mOsm / L.

7. The ready to drink electrolyte solution according to claim 1, wherein the chromium salt is chromium picolinate.

8. The ready to drink electrolyte solution according to claim 1, wherein the chromium ions are present in the form of chromium picolinate and the concentration of chromium picolinate is less than or equal to 240pg / 100mL.

9. The ready to drink electrolyte solution according to claim 1 , wherein the theoretical glycemic index of the solution is less than or equal to 52.

10. The ready to drink electrolyte solution according to claim 1 , wherein the solution as a calorie content less than or equal to 35kcal per 100ml.

11. The ready to drink electrolyte solution according to claim 1 , wherein the solution further comprises metallic ions selected from: calcium, iron, zinc, or combinations thereof.

12. The ready to drink electrolyte solution according to claim 1, wherein the solution further comprises at least one vitamin.

13. The ready to drink electrolyte solution according to claim 1 , comprising: isomaltulose, at a concentration from 1g to lOg / lOOmL, glucose, at a concentration from 0.9g to 2g / 100mL, sodium ions, at a molarity from 35mmol / L to 65mmol / L, and chromium salt in the form of chromium picolinate, at a concentration from lOpg / lOOmL to 120pg / 100mL, wherein the theoretical glycemic index of the solution is equal to or less than 50.

14. A method for the manufacture of the ready to drink electrolyte solution according to claim 1, comprising: dissolving isomaltulose, dextrose and at least one sodium salt in water, to obtain a first solution, dissolving chromium salt in water at a temperature suitable to dissolve the chromium salt to obtain a chromium salt solution, and combining the chromium salt solution and the first solution.

15. A method of rehydrating a patient suffering from dehydration, the method comprising administering the ready to drink electrolyte solution according to claim 1 to a patient suffering from dehydration.

16. A method of rehydrating a patient suffering from cancer or diabetes, the method comprising administering the ready to drink electrolyte solution according to claim 1 to a patient suffering from cancer or diabetes.

17. A method of rehydrating an elderly patient, the method comprising administering the ready to drink electrolyte solution according to claim 1 to an elderly patient.

18. A method of rehydrating and providing an energy supplementation to a patient suffering from acute or chronic illness, the method comprising administering the ready to drink electrolyte solution according to claim 1 to a patient suffering from acute or chronic illness and needing an energy supplementation.

19. A method of rehydrating a patient suffering from a gastrointestinal disorder, such as irritable bowel syndrome or inflammatory bowel disease, the method comprising administering the ready to drink electrolyte solution according to claim 1 to a patient suffering from a gastrointestinal disorder.

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