Polypeptide cosmetic compositions

A cosmetic composition with a polypeptide and activators synergistically enhances collagen production, overcoming limitations of individual components, thereby effectively addressing skin aging and improving skin appearance.

WO2026019727A1 Publication Date: 2026-01-22ELC MANAGEMENT LLC
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Patent Information

Application Number
PCT/US2025/037582
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2025-07-10
Filing Date
2025-07-14
Publication Date
2026-01-22

AI Technical Summary

Technical Problem

Existing cosmetic compositions fail to effectively stimulate collagen production synergistically, with individual components showing minimal or no enhancement when combined at identical concentrations.

Method used

A cosmetic composition comprising a polypeptide with 5 amino acid residues or less, combined with a first polypeptide activator containing a guanine nucleotide and a second polypeptide activator comprising succinic acid, which interact synergistically to significantly enhance collagen production.

Benefits of technology

The synergistic interaction results in a substantial increase in collagen production, exceeding the sum of individual component contributions, effectively addressing skin aging and improving skin appearance.

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Abstract

Polypeptide cosmetic compositions may be useful for addressing skin conditions. Such skin conditions include loss of firmness, lines and wrinkles, and other age-related skin changes associated with the general degradation of the skin dermis, which are often characterized by collagen loss and structural disorganization. Cosmetic compositions may comprise a polypeptide, a first polypeptide activator comprising a guanine nucleotide, and a second polypeptide activator comprising succinic acid. Preferably, the polypeptide has about 5 amino acid residues or less, and more preferably, the polypeptide comprises a tripeptide having an amino acid sequence of Ser-Thr-Pro-NH2. Preferred polypeptides may promote stimulation of collagen production in skin cells to which the cosmetic compositions are applied.
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