Method for treating hyperkalemia with poly(2-fluoroacrylic acid-pentaerythritol triallyl ether) iron calcium sodium salt

By using poly(2-fluoroacrylate-pentaerythritol triallyl ether) iron calcium sodium salt to treat hyperkalemia, the problems of slow onset of action, multiple side effects, and poor patient compliance of existing drugs have been solved. This method achieves rapid reduction of blood potassium levels and avoids adverse reactions, thus improving the safety of treatment and patient compliance.

WO2026056759A1 Publication Date: 2026-03-19WATERSTONE PHARMA (WUHAN) CO LTD
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Patent Information

Application Number
PCT/CN2025/119237
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-09-13
Filing Date
2025-09-05
Publication Date
2026-03-19

AI Technical Summary

Technical Problem

Existing medications for hyperkalemia have problems such as slow onset of action, numerous side effects, adverse reactions to sodium ion exchange-induced edema, adverse reactions to magnesium ...

Method used

Poly(2-fluoroacrylate-pentaerythritol triallyl ether) iron calcium sodium salt was used as the cation exchange resin to address adverse reactions such as edema, magnesium ion exchange-induced edema, magnesium ion exchange-induced edema, magnesium ion exchange-induced edema, hypomagnesemia, and poor patient compliance.

Benefits of technology

It achieves rapid reduction of serum potassium levels, avoids adverse reactions such as edema and hypomagnesemia, improves patient compliance, and has a rapid onset of action, effectively reducing serum potassium levels within 1 hour after the first dose.

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Abstract

The present invention relates to a method for preventing or treating hyperkalemia in a subject. The method comprises a first-stage dosing regimen in which poly(2-fluoroacrylic acid-pentaerythritol triallyl ether) iron calcium sodium salt is orally administered to the subject 3 times a day, 3 g to 48 g each time, for 2 consecutive days. Optionally, the method comprises a second-stage dosing regimen in which 3 g to 48 g of poly(2-fluoroacrylic acid-pentaerythritol triallyl ether) iron calcium sodium salt is orally administered to the subject once a day or once every other day.
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