Zwitterionic metal chelators

Zwitterionic metal chelators with PCTA derivatives and targeting vectors address solubility and interaction issues, enhancing medical imaging and chemical process efficiency by improving solubility and clearance.

WO2026112181A1PCT designated stage Publication Date: 2026-05-28CURADEL SURGICAL INNOVATIONS INC
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
CURADEL SURGICAL INNOVATIONS INC
Filing Date
2025-11-19
Publication Date
2026-05-28

AI Technical Summary

Technical Problem

Existing metal chelators lack solubility in aqueous environments, result in non-specific interactions, and are not efficiently cleared from the body, leading to high background and toxicity in medical applications, and poor yield and side reactions in chemical processes.

Method used

Development of zwitterionic metal chelators with zwitterionic groups that enhance solubility, minimize non-specific interactions, and facilitate rapid equilibration and clearance, using derivatives of 3,6,9,15-Tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3,6,9-triacetic acid (PCTA) with targeting vectors like cRGD, PSMA-617, and FAPI, allowing for efficient chelation at room temperature.

Benefits of technology

Improves signal-to-background ratio and therapeutic window in medical imaging, enhances solubility and minimizes non-specific interactions in chemical processes, and facilitates efficient clearance from the body.

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Abstract

The present invention relates to zwitterionic metal chelators and their use as imaging, diagnostic, chemical processing, and treatment agents. These zwitterionic metal chelators have desirable properties that maximize solubility in aqueous environments, minimize non-specific interactions, and retain the ability to target thus resulting in an improved performance in a variety of medical, agricultural, and chemical processes. In in vivo and medical applications, zwitterionic metal chelators improve the signal-to-background ratio and therapeutic window as compared to other metal chelators while retaining high stability.
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