Improved promoters and compositions

Activatable promoters with photocleavable moieties address the regulation and encapsulation challenges of existing systems, enabling precise gene expression and translation in synthetic cells.

AU2023258391B2Pending Publication Date: 2026-07-23OXFORD UNIVERSITY INNOVATION LTD
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Patent Information

Authority / Receiving Office
AU · AU
Patent Type
Applications
Current Assignee / Owner
OXFORD UNIVERSITY INNOVATION LTD
Filing Date
2023-11-01
Publication Date
2026-07-23

AI Technical Summary

Technical Problem

Existing inducible transcription and translation systems lack stringent regulation between activated and repressed states, and are difficult to encapsulate in synthetic cells, limiting their application in synthetic biology.

Method used

Development of activatable promoters with photocleavable moieties that uncouple transcription inhibition moieties upon exposure to electromagnetic radiation, allowing for precise control of transcription and translation in synthetic cells.

Benefits of technology

Enables stringent regulation of gene expression and encapsulation in synthetic cells, providing flexible and controlled production of biological molecules.

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Abstract

IMPROVED PROMOTERS AND COMPOSITIONS 5 The present invention relates to activatable promoters, as well as expression systems, vectors, delivery systems, reaction vessels, aqueous objects and compositions comprising said activatable promoters. The invention also provides compositions comprising assemblies and networks of aqueous objects comprising said activatable promoters. The invention additionally provides methods of expressing a transcript and methods of expressing a 10 polypeptide using the activatable promoters of the invention. The invention further provides phospholipid mixtures, as well as aqueous objects and compositions comprising said phospholipid mixtures.20 23 25 83 91 01 N ov 2 02 3 A B S T R A C T N o v 2 0 2 3 I M P R O V E D P R O M O T E R S A N D C O M P O S I T I O N S 2 0 2 3 2 5 8 3 9 1 0 1 1 0
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