PROCESSO PARA PRODUZIR UMA DISPERSÃO AQUOSA DE UM COMPOSTO DE FILTRO ULTRAVIOLETA ORGÂNICO SÓLIDO INSOLÚVEL EM ÁGUA

Abstract

A process for producing an aqueous dispersion of a water-insoluble, solid organic UV filter compound, comprising the steps of providing water, a dispersant, and a powder comprising the water insoluble, solid organic UV filter compound; providing an aqueous dispersant solution by adding the dispersant to the water in an amount of 0.001 to 0.25 wt.-% with respect to the total weight of the aqueous dispersant solution leaving a remaining amount of the dispersant; dispersing, using an inline disperser, the powder comprising the water insoluble, solid organic UV filter compound in the aqueous dispersant solution yielding a first aqueous dispersion; adding the remaining amount of the dispersant to the first aqueous dispersion yielding a second aqueous dispersion; further dispersing the second aqueous dispersion yielding the aqueous dispersion of a water-insoluble, solid organic UV filter compound, wherein the total amount of dispersant is higher than 0.25 wt.-% with respect to the total weight of the aqueous dispersant solution.

Description

[001] This invention relates to a process for producing suspensions of water-insoluble organic UV absorbers using an in-line disperser. Foaming is reduced by optimizing the dispersant level and the dosing process in the mixing device. The process is economical and reduces EHS measures in the installation. The resulting suspensions are suitable for wet milling in a stirred media mill to obtain micronized UV filters for use in cosmetic sunscreens. Fundamentals

[002] Dispersions of micronized organic UV absorbers are well described in the literature. Particulate organic UV absorbers suitable for use in cosmetic sunscreens are described, for example, in documents WO 95 / 22959 A1, WO 97 / 03643 A1, WO 2009 / 077356 A1 and WO 2015 / 155158 A1.

[003] Generally, some of the UV absorbers commonly used are insoluble in water. For the production of products that use such water-insoluble UV absorbers, it is necessary, however, to disperse them in water as finely as possible. Thus, the process of dispersing such UV absorbers has been constantly the subject of improvements in recent years.

[004] In particular, the use of dispersants has been a topic of research over the years. Document WO 97 / 03643 A1 provides a method for producing a composition of a micronized organic UV absorber, comprising triturating the UV absorber in the presence of an alkyl polyglycoside. Further trituration aids are provided in Petition 870250083710, dated 09 / 17 / 2025, page 48 / 82 / 29 document WO 2009 / 068469 A1.

[005] Therefore, the formation of a fluid paste is a crucial step in the large-scale production of micronized organic UV filter dispersions. As mentioned above, particulate UV absorbers are water-insoluble crystalline materials obtained as low-density powders, which are explosive in dust form. Safety measures must be implemented when such powders are introduced into the receptacle containing the liquid phase.

[006] A problem during the dispersion of said UV filters is foam formation. Because the powder density is less than the actual density, the powder contains air. Wetting the UV filter powder with liquid releases air into the bulk phase and thus generates foam. In addition, the use of dispersants, especially surfactants, also promotes foam formation. Foam formation also occurs when the process or equipment used for mixing and homogenizing the suspension is not suitable. Foam is prohibitive for any stable and robust wet milling process in a stirred media mill. Therefore, avoiding foam formation in the dispersion process of said UV filters has been an important issue.

[007] In WO 2009 / 003934 A1, dispersions are prepared by grinding UV filter in an apparatus comprising yttrium-stabilized zirconium oxide grinding spheres in the presence of an antifoaming agent. WO 2017 / 198806 A1 describes the wet milling of organic UV filter suspensions in more detail. A formulation comprising water, dispersant, and antifoaming agent is prepared, and UV filter powder is added to form a fluid paste. This fluid paste is pre-ground using a colloid mill and then finely ground in a stirred media mill to achieve a d50 average particle size of 100 to 170 nm. Petition 870250083710, dated 09 / 17 / 2025, page 49 / 82 / 29

[008] However, the use of antifoaming agents means that they are part of the product formulation, which is not always acceptable to customers.

[009] Document WO 2018 / 069200 A1 provides a wet grinding process in a stirred media mill without using an antifoaming agent. The UV filter suspension is prepared in a receptacle by slowly adding the UV filter powder to the water / alkyl polyglycoside mixture. The suspension is degassed under gentle stirring in a heating / cooling cycle before the grinding process begins. It is stated that by selecting a specific particle size in the UV filter suspension, foam formation during wet grinding is controllable. Further reduction in foam formation is achieved by using a specific alkyl polyglycoside as the dispersant.

[0010] However, a degassing step prior to wet milling, as described in WO 2018 / 069200 A1, is expensive and time-consuming, especially on a production scale. Summary of the Invention

[0011] Thus, the objective of the present invention is to provide a scalable process for the dispersion of a water-insoluble solid organic UV filter in an aqueous phase, without adding antifoaming agents to the aqueous phase and without degassing steps in the process.

[0012] It has now been surprisingly verified that this objective is solved by a process in which an aqueous dispersant solution is provided, wherein the amount of dispersant is in a range of 0.001 to 0.25% by weight relative to the total weight of the aqueous dispersant solution; subsequently the UV filter powder is dispersed in this aqueous dispersant solution producing a first aqueous dispersion and, after this dispersion, the remaining dispersant is added. This concentration range refers to the active level of the dispersant in the liquid before the addition of powder.

[0013] The advantageous technical effect of the present invention is that a Petition 870250083710, dated 09 / 17 / 2025, page 50 / 82 / 29: an aqueous UV filter dispersion can be prepared with significantly reduced or even completely suppressed foam formation, thus eliminating the need for any additional degassing steps, resulting in a quick and efficient way to wet a water-insoluble solid organic UV filter. Brief Description of the Drawings

[0014] Figure 1 is a schematic drawing of the device configuration as used in examples CE1, CE2, IE1 and IE2.

[0015] Figure 2 is an image of the aqueous phase and the foam produced in Comparative Example CE1.

[0016] Figure 3 is an image of the aqueous phase and the foam produced in Comparative Example CE1.

[0017] Figure 4A is an image of the number of particles having a diameter of 500 pm or more (left-handed sieves) and a diameter in the range of 200 to 500 pm (right-handed sieves) for probe A of Comparative Example CE2.

[0018] Figure 4B is an image of the number of particles having a diameter of 500 pm or more (left-handed sieves) and a diameter in the range of 200 to 500 pm (right-handed sieves) for probe B of Comparative Example CE2.

[0019] Figure 4C is an image of the number of particles having a diameter of 500 pm or more (left-handed sieves) and a diameter in the range of 200 to 500 pm (right-handed sieves) for probe C of Comparative Example CE2.

[0020] Figure 4D is an image of the number of particles having a diameter of 500 pm or more (left-handed sieves) and a diameter in the range of 200 to 500 pm (right-handed sieves) for probe D of Comparative Example CE2. Petition 870250083710, dated 09 / 17 / 2025, pages 51 / 82 / 29 Definitions

[0021] As used in this descriptive report and the appended claims, the singular forms of “a” and “an” also include their respective plurals, unless the context clearly indicates otherwise. In the context of the present invention, the terms “about” and “approximately” denote a range of precision that one skilled in the art will understand to still ensure the technical effect of the feature in question. The term typically indicates a deviation from the stated numerical value of ±20%, preferably ±15%, more preferably ±10%, and even more preferably ±5%. It should be understood that the term “comprising” is not limiting. For the purposes of the present invention, the term “consisting of” is considered to be a preferred embodiment of the term “composed of”. If hereinafter a group is defined to comprise at least a certain number of embodiments, this will also mean encompassing a group that preferably consists only of those embodiments.Furthermore, the terms “first”, “second”, “third” or “(a)”, “(b)”, “(c)”, “(d)”, etc. and the like in the description and claims are used to distinguish between similar elements and not necessarily to describe a sequential or chronological order. It should be understood that the terms thus used are interchangeable in appropriate circumstances and that the embodiments of the invention described herein are capable of operating in sequences other than those described or illustrated herein. If the terms “first”, “second”, “third” or “(a)”, “(b)”, “(c)”, “(d)”, “i”, “ii”, etc. refer to steps of a method or use or trial, there is no coherence of time or time interval between the steps, i.e., the steps may be performed simultaneously or there may be time intervals of seconds, minutes, hours, days, weeks, months or even years between such steps, unless otherwise indicated in the application, as set forth above or below.It should be understood that this invention is not limited to methodology, protocols, reagents, etc. Petition 870250083710, dated 09 / 17 / 2025, p. 52 / 82 / 29 specific terms described in this document, as these may vary. It should also be understood that the terminology used in this document is intended to describe only specific embodiments and is not intended to limit the scope of the present invention, which will be limited only by the appended claims. Unless otherwise defined, all technical and scientific terms used in this document have the same meanings commonly understood by one skilled in the art.

[0022] As used in this document, the term “does not comprise” or “free from” means, in this context, that the composition of the present invention is free from a specific compound or group of compounds, which may be combined under a collective term, that the composition does not comprise said compound or group of compounds in an amount greater than 0.8% by weight, based on the total weight of the composition. Furthermore, it is preferable that the composition according to the present invention does not comprise said compounds or group of compounds in an amount greater than 0.5% by weight, preferably the composition does not comprise said compounds or group of compounds at all.

[0023] When referring to the compositions and the percentage by weight of the ingredients contained therein, it should be understood that, according to the present invention, the total quantity of ingredients does not exceed 100% (± 1% due to rounding).

[0024] The term “sunscreen composition” or “sunscreen” refers to any topical product that absorbs and may additionally reflect and scatter certain portions of UV radiation. Thus, the term “sunscreen composition” should be understood not only as including sunscreen compositions but also any cosmetic compositions that provide UV protection. The term “topical product” refers to a product that is applied to the skin and may refer, for example, to sprays, lotions, creams, oils, foams, powders, or gels. According to the present invention, the Petition 870250083710, dated 09 / 17 / 2025, page 53 / 82 / 29 The composition of sunscreen may include one or more active agents, for example, organic and inorganic UV filters, as well as other ingredients or additives, for example, emulsifiers, emollients, viscosity regulators, stabilizers, preservatives or fragrances.

[0025] The term “daily care composition” refers to any topical product that absorbs and may additionally reflect and scatter certain portions of UV radiation and is used as a daily care product for the human body, for example, for the face or body. The daily care composition may comprise one or more active agents, for example, organic and / or inorganic UV filters, as well as other ingredients or additives, for example, emulsifiers, emollients, viscosity regulators, stabilizers, preservatives, or fragrances. Suitable daily care compositions are, according to the present invention, for example, no-rinse facial and body care products.

[0026] No-rinse products suitable for face and body are, for example, sunscreen compositions, decorative preparations and skin care preparations.

[0027] Suitable decorative preparations include, for example, lipsticks, nail polishes, eyeshadows, mascaras, dry and wet makeup, blush, powders, depilatory agents and bronzing lotions.

[0028] Suitable skin care preparations are, for example, preparations for hydration, refinement, and firming. The daily care compositions mentioned may be in the form of creams, ointments, pastes, foams, gels, lotions, powders, makeup, sprays, sticks, or aerosols. The daily care compositions are therapeutic daily care compositions because they include UV filters.

[0029] The term “UV filter” or “ultraviolet filter”, as used in this document, refers to organic or inorganic compounds that can absorb and can additionally reflect and scatter UV radiation caused Petition 870250083710, dated 17 / 09 / 2025, p. 54 / 82 / 29 regarding sunlight. The UV filter can be classified based on its UV protection curve, as UV-A, UV-B or broadband filters. Preferably, the term “UV filter” includes or consists of any UV filter as defined in Annex VI (version of 03 / 12 / 2020) of Regulation (EC) No 1223 / 2009 of the European Parliament and of the Council.

[0030] Water-soluble UV filters have a solubility in water of at least 2% by weight, preferably at least 3% by weight, more preferably at least 5% by weight.

[0031] The prefix Cn-Cm indicates, in each case, the possible number of carbon atoms in the group.

[0032] The term “C12-C15 alkyl benzoate” refers to benzoic acid esters with fatty alcohols containing a C12-C15 alkyl chain. The C12-C15 alkyl chain is defined as an alkyl chain with a chain length of C12, C13, C14, or C15.

[0033] The term “Cn-Cm carboxylic acids”, as used in this document, denotes, in each case, a linear or branched carboxylic acid having nam carbon atoms, such as 6 to 24 carbon atoms.

[0034] The term “Cn-Cm alcohols”, as used in this document, denotes, in each case, a linear or branched alcohol having nam carbon atoms, as having from 3 to 24 carbon atoms, or from 6 to 24 carbon atoms, or from 1 to 22 carbon atoms.

[0035] The term “C2-C12 dicarboxylic acids”, as used in this document, denotes, in each case, a dicarboxylic acid having 2 to 12 carbon atoms, such as butanedioic acid (succinic acid), pentanedioic acid (glutaric acid), hexanedioic acid (adipic acid) or decanodioic acid (sebacic acid).

[0036] The term “dialkyl ether”, as used in this document, denotes, in each case, a linear or branched dialkyl ether having a total of 12 to 36 carbon atoms and comprising at least an ether fraction. Petition 870250083710, dated 09 / 17 / 2025, page 55 / 82 / 29

[0037] The term “C6-C22 alcohol carbonates”, as used in this document, denotes, in each case, a linear or branched alcohol carbonate having from 6 to 22 carbon atoms and comprising at least one functional group consisting of a carbonyl group flanked by two alkoxy groups.

[0038] The term “alkyl”, as used in this document, denotes, in each case, a straight or branched chain alkyl group having, for example, from 1 to 18 carbon atoms. Examples of an alkyl group are methyl, ethyl, n-propyl, iso-propyl, n-butyl, 2-butyl, iso-butyl, tert-butyl, n-pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2di-methylpropyl, 1-ethylpropyl, n-hexyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1dimethyl-butyl, 1,2-dimethylbutyl, 1,3-dimethyl-butyl, 2,2-dimethylbutyl, 2,3dimethylbutyl, 3,3-dimethyl-butyl, 1-ethylbutyl, 2-ethylbutyl, 1,1,2trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethyl-1-methyl-propyl and 1-ethyl-2methylpropyl.

[0039] The term “alkoxy”, as used in this document, denotes in each case a linear or branched alkyl group that is linked via an oxygen atom and generally has from 1 to 20 carbon atoms. Examples of an alkoxy group are methoxy, ethoxy, n-propoxy, iso-propoxy, n-butyloxy, 2-butyloxy, iso-butyloxy, tert-butyloxy and the like.

[0040] The term “carboxyalkyl”, as used in this document, includes carboxymethyl, carboxyethyl, carboxypropyl, carboxy-isopropyl, carboxybutyl, carboxy-isobutyl, carboxyamyl, carboxy-hexyl, carboxy-heptyl, carboxyoctyl, carboxy-iso-octyl, carboxinonyl, carboxydecyl, carboxyundecyl, carboxydodecyl, carboxytetradecyl, carboxy-hexadecyl and carboxyoctadecyl, carboxymethyl being preferred.

[0041] The term “cycloalkyl”, as used in this document, denotes, in each case, a monocyclic cycloaliphatic radical generally having Petition 870250083710, dated 09 / 17 / 2025, p. 56 / 82 / 29 of 3 to 10 or 5 to 8 carbon atoms, such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl and cyclodecyl or cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl.

[0042] The term “substituted,” as used in this document, means that a hydrogen atom bonded to a designated atom is replaced by a specified substituent, provided that the substitution results in a stable or chemically viable compound. Unless otherwise indicated, a substituted atom may have one or more substituents, and each substituent is selected independently.

[0043] The term “Solid organic insoluble UV filter” refers to a plurality of UV filter particles with a specific particle size distribution.

[0044] The size of the UV filter particles in the present invention is defined by the particle size distribution of a set of particles, which can be distinguished with respect to particle volume (mass). Volume-based distributions can be obtained by laser diffraction, and many commercial instruments are available, for example, from Anton Paar (PSA series), Microtrac MRB (Sync) or Malvern Panalytical (Mastersizer series). Depending on the sensitivity and resolution of the instrument selected, the numerical results that distinguish the particle size distribution will differ within a small range. Those skilled in the art know how to handle these deviations, and these instruments are routinely used in R&D and quality control laboratories.

[0045] The term “dispersion”, as used in this document, refers to a system in which distributed particles of one material are dispersed in a continuous phase of another material. The two phases may be in the same or different states of matter. A specific subtype of a dispersion is the “suspension”, in which solid parts are dispersed (i.e., not dissolved) in a fluid. Petition 870250083710, dated 09 / 17 / 2025, page 57 / 82 / 29 Description of the Invention

[0046] The present invention provides a process for producing an aqueous dispersion of a water-insoluble solid organic UV filter compound, comprising the steps of: a) provide water, preferably distilled water, more preferably double-distilled water, a dispersant and a powder comprising the water-insoluble solid organic UV filter compound; b) To provide an aqueous dispersant solution, add the dispersant to water in an amount of 0.001 to 0.25% by weight relative to the total weight of the aqueous dispersant solution, leaving a remaining amount of dispersant; c) disperse, using an in-line disperser, the powder comprising the water-insoluble solid organic UV filter compound in the aqueous dispersing solution, producing a first aqueous dispersion; d) add the remaining amount of dispersant to the first aqueous dispersion, producing a second aqueous dispersion; e) further disperse the second aqueous dispersion, producing an aqueous dispersion of a water-insoluble solid organic UV filter compound, wherein the total amount of dispersant is greater than 0.25% by weight relative to the total weight of the aqueous dispersing solution.

[0047] The process is controlled, in particular, by the concentration of dispersant used in the aqueous phase before the dispersion step. Preferably, the process is carried out using recycling. In such a preferred embodiment, the aqueous dispersion is added to step c) again. Therefore, preferably, the dispersant concentration is kept constant in the range of 0.001 to 0.25% by weight relative to the total weight of the aqueous dispersant solution until step c) is completed, i.e., the total amount of water-insoluble solid organic UV filter has been added, recycling Petition 870250083710, dated 09 / 17 / 2025, page 58 / 82 / 29 thus the dispersion. After the completion of step c), the remaining dispersant is added in step d).

[0048] Preferably, in step b), the dispersant is added in an amount less than 0.24% by weight relative to the total weight of the aqueous dispersant solution, preferably in an amount less than 0.2% by weight and, more preferably, in an amount less than 0.15% by weight. If the dispersant is added in an amount less than 0.24% by weight, foam formation will be significantly reduced. If the dispersant is added in an amount less than 0.15% by weight, foam formation will be suppressed.

[0049] Suitable dispersants are, in particular, polyglycerol alkyl ester, preferably polyglycerol monoalkyl ester, and alkyl polyglucoside, preferably having the formula CnH2n+1O(C6H10O5)xH, where n is an integer ranging from 8 to 16, ex is the average polymerization level of the glycosidic fraction (C6H10O) and ranges from 1.4 to 1.6, or an ester thereof. Other suitable dispersing agents are described in WO 2009 / 7068469 A1.

[0050] According to the present invention, the monoalkyl ester of polyglycerol preferably has an average degree of glycerol polymerization of 5 or more.

[0051] In a preferred embodiment, at least one monoalkyl ester of polyglycerol is selected from the group consisting of decaglyceryl caprate, decaglyceryl monolaurate, decaglyceryl myristate, decaglyceryl oleate, decaglyceryl stearate, decaglyceryl isostearate, hexaglyceryl caprate, hexaglyceryl laurate, hexaglyceryl myristate, hexaglyceryl oleate, hexaglyceryl stearate, hexaglyceryl isostearate, pentaglyceryl caprate, laurate of Petition 870250083710, dated 09 / 17 / 2025, p. 59 / 82 / 29 pentaglyceryl, pentaglyceryl myristate, pentaglyceryl oleate, pentaglyceryl stearate, pentaglyceryl isostearate and combinations thereof. In a specific preferred embodiment, at least one polyglycerol monoalkyl ester is decaglyceryl monolaurate (INCI polyglyceryl-10 laurate).

[0052] Monoalkyl polyglycerol esters having an HLB (hydrophilic-lipophilic balance) of 14.5 or more are preferred, and those having an HLB of 15 or more are more preferred. The HLB value is determined by the formula HLB = 20 • Mh / M, where Mh is the molecular mass of the hydrophilic portion of the molecule and M is the molecular mass of the entire molecule.

[0053] Monoalkyl esters of polyglycerol having an HLB lower than 14.5 may take longer for the dispersion of micronized methylene bisbenzotriazolyl tetramethylbutylphenol in aqueous phase components. Examples of polyglycerol monoalkyl esters with an average degree of polymerization of 5 or more and having an HLB of 14.5 or more may include decaglyceryl caprate, decaglyceryl monolaurate, decaglyceryl myristate, decaglyceryl oleate, decaglyceryl stearate, decaglyceryl isostearate, hexaglyceryl laurate, pentaglyceryl laurate, pentaglyceryl myristate, pentaglyceryl stearate, and pentaglyceryl oleate, and those having an HLB of 15 or more may include decaglyceryl caprate and decaglyceryl monolaurate.

[0054] Particularly preferred are polyglyceryl monolaurate, particularly decaglyceryl monolaurate and decyl glucoside.

[0055] Preferably, the alkyl polyglycoside consists of a C1-C12 ester of the compound with the formula CnH2n+1O(C6H10O5)xH, that is, an ester formed by the reaction of a C1-C12 carboxylic acid with one or more free PH groups of the glycosidic moiety (C6H10O). In this context, it is preferable that the Petition 870250083710, dated 09 / 17 / 2025, page 60 / 82 / 29 ester is formed by the reaction of formic, acetic, propionic, butyric, sulfosuccinic, citric or tartaric acid with one or more free OH groups in the glycosidic fraction (C6H10O).

[0056] Suitable alkyl polyglycosides according to the present invention are alkyl polyglycosides known by the INCI name “decyl glucoside” [CAS 68515-73-1], such as, in particular, the C8-16 alkyl polyglycoside that is available, for example, as PlantaCare 2000 UP from BASF. Preferably, the dispersant is an alkyl glycoside, more preferably a polyalkyl glycoside, and most preferably the active compound of Plantacare® 2000 UP. It should be understood that the term dispersant, as used in this document, denotes the active surfactant compound. Therefore, for example, if the dispersant is added as a solution in water, only the amount of surfactant contained therein is relevant.

[0057] The term insoluble solid organic UV filter refers to UV filters that are not soluble in water and cosmetic oils at 25°C. On the other hand, water-soluble UV filters have a water solubility of at least 2% by weight, preferably at least 3% by weight, more preferably at least 5% by weight, and oil-soluble UV filters have a solubility in common cosmetic oils such as C12-C15 alkyl benzoate, dibutyl adipate, diisopropyl sebacate, phenethyl benzoate or dicaprylyl carbonate of at least 2% by weight, preferably at least 5% by weight, more preferably at least 7% by weight.

[0058] It is preferable that the insoluble solid organic UV filter be selected from the group consisting of tris-biphenyl triazine, 1,1'-(1,4-piperazinodi-yl)bis[1-[2-[4-(diethylamino)-2-hydroxybenzoyl]phenyl]-methanone, phenylene bis-diphenyltriazine and 2,2'-methylenebis[6-(2 H-1,2,3-benzotriazol-2-yl)4-(2,4,4-trimethylpentan-2-yl)phenol].

[0059] Tris-biphenyl triazine has the following structure: Petition 870250083710, dated 09 / 17 / 2025, pp. 61 / 82 15 / 29

[0060] 1,1'-(1,4-piperazinodi-yl)bis[1-[2-[4-(diethylamino)-2hydroxybenzoyl]phenyl]-methanone has the following structure:

[0061] Phenylene bis-diphenyltriazine has the following structure:

[0062] 2,2'-methylenebis[6-(2 / / -1,2,3-benzotriazol-2-yl)-4-(2,4,4trimethylpentan-2-yl)phenol] has the following structure:

[0063] According to one embodiment of the invention, the UV Filter Petition 870250083710, dated 09 / 17 / 2025, page 62 / 82 / 29, the insoluble solid organic substance is 1,1'-(1,4-piperazinodi-yl)bis[1-[2-[4-(diethylamino)2-hydroxybenzoyl]phenyl]-methanone.

[0064] According to another embodiment of the invention, the insoluble solid organic UV filter is tris-biphenyl triazine. Tris-biphenyl triazine (also: TBPT) is a broad-spectrum UV filter that offers high performance across the entire UV-A and UV-B spectrum.

[0065] According to another embodiment of the invention, the insoluble solid organic UV filter is 2,2'-methylenebis[6-(2H-1,2,3-benzotriazol-2-yl)-4(2,4,4-trimethylpentan-2-yl)phenol]. 2,2'-methylenebis[6-(2H-1,2,3-benzotriazol-2-yl)-4-(2,4,4-trimethylpentan-2-yl)phenol] is a highly effective broadband UV filter that covers the entire UV-A and UV-B spectrum.

[0066] Therefore, more preferably, the water-insoluble solid organic UV filter compound is 2,2'-Methylenebis[6-(2H-1,2,3benzotriazol-2-yl)-4-(2,4,4-trimethylpentan-2-yl)phenol] (MBBT) or 2,4,6Tris([1,1'-biphenyl]-4-yl)-1,3,5-triazine (TBPT).

[0067] In the process according to the present invention, the powder preferably consists of a water-insoluble solid organic UV filter compound. Preferably, the powder has a bulk density in the range of 200 to 800 kg / m3. More preferably, the powder has a median particle size D50 in the range of 30 to 400 μm, wherein the particle size is measured by laser diffraction using a Mastersizer 3000 (Malvern Panalytical) and / or a particle size D90 determined by laser diffraction in the range of 100 to 1,000 μm. This ensures that the surface area of ​​the water-insoluble solid organic UV filter is high enough to make it dispersible in water. Basic information on the laser diffraction method and how to determine the particle size distribution of UV filter powders can be found in document WO 2018 / 069200 A1.

[0068] Step c) is performed using an in-line scatterer. In-line scatterers are well-known means of obtaining a rapid Petition 870250083710, dated 17 / 09 / 2025, page 63 / 82 / 29 incorporation of powders into liquids and are commercially available, for example, from IKA GmbH & Co. KG, Ystral GmbH and Netzsch GmbH & Co. KG. Basically, an in-line disperser consists of a mixing chamber that is connected to the powder supply, i.e., a powder fluidization device. The liquid passes rapidly through a mixing chamber and creates entrainment. The powder is drawn into the mixing chamber and deaerated to a certain extent before coming into contact with the liquid. This improves the wetting process and reduces the formation of stable foam in the dispersion. Safety measures are reduced as explosive dust in the receptacle is avoided. Thus, preferably, in step c), the powder is added under vacuum.Thus, the term “added under vacuum” as used in this document denotes a process step or device that produces a pressure lower than the ambient pressure and therefore a driving force for the powder, preferably fluidized powder, to be added. A lower internal pressure is produced, for example, by an in-line disperser during operation. The lower internal pressure is used to support the movement of the powder, preferably fluidized powder, from the powder supply to the dispersion chamber of the in-line disperser, thereby increasing the overall dispersion efficiency of the device and the process. Preferably, rapid deaeration of the water-insoluble solid organic UV filter powder occurs in the receptacle, which is further enhanced by the use of a high-energy mixer / agitator for homogenization of the fluid paste in the receptacle. Furthermore, an in-line disperser is suitable for continuous processes and can be easily installed in a process.

[0069] Therefore, the device for carrying out the process of the present invention comprises an in-line dispenser, wherein the inlet of the in-line dispenser is connected to a supply vessel, which retains the liquid phase. The line connecting the supply vessel includes a dosing device for dosing the dispersant into the supply line. Petition 870250083710, dated 09 / 17 / 2025, page 64 / 82 / 29 This dosing device may comprise a dosing pump and a dosing valve. Finally, the powder inlet of the in-line disperser is preferably connected to a powder fluidization device, and the dispersant dosing will be positioned downstream of the in-line disperser.

[0070] In a preferred embodiment of the device of the present invention, the outlet of the in-line disperser is connected to the supply container. However, in this case, the outlet line preferably extends into the supply container in the form of an immersion tube. Furthermore, the dispersant dosing is positioned upstream of the supply container in such a preferred embodiment. The configuration of such a preferred embodiment is suitable for carrying out the process of the present invention in terms of recycling, whereby the dispersion formed in the in-line disperser is added to the supply container and thus redispersed.

[0071] Preferably, the supply vessel comprises a mixer, more preferably a jet mixer. It has been surprisingly found that a jet mixer, despite the higher mixing rates applied, is able to significantly reduce the appearance of bubbles in the supply vessel if the device is used in recycling mode, i.e., connecting the outlet of the in-line disperser to the supply vessel. In this way, the air introduced by the powder into the in-line disperser is released into the supply vessel. If a jet mixer is not used, large bubbles will form, further hindering the process and reducing efficiency. Therefore, a jet mixer improved the efficiency of the process by eliminating the formation of large air bubbles.

[0072] Therefore, the process of the present invention provides, in step c), a preferred powder addition rate in the range of 20 to 200 kg / min, more preferably in the range of 100 to 150 kg / min, and most preferably in the range Petition 870250083710, dated 17 / 09 / 2025, page 65 / 82 / 29 of 130 to 140 kg / min. Preferably, in step c), the powder is a fluidized powder. Thus, the process of the present invention is significantly faster than the process that includes degassing steps, as described, for example, in document WO 2018 / 069200 A1.

[0073] Preferably, the in-line disperser comprises a high-shear mixer. Even more preferably, in step c), the high-shear mixer is operated at a rotational speed in the range of 2,000 to 4,000 rpm, preferably 2,500 to 3,600 rpm and most preferably 2,900 to 3,100 rpm. This range has been found to achieve the best results for step c) of the process. This range has the effect of leading the water-insoluble solid organic UV filter to disperse, even at low dispersant levels, as provided in step b).

[0074] Preferably, step c) and step e) are carried out in similar devices or even in the same device. Therefore, preferably, step e) is carried out using an in-line disperser, preferably an in-line disperser comprising a high-shear mixer. Even more preferably, in step e), the high-shear mixer is operated at a rotational speed in the range of 2,500 to 4,500 rpm, preferably 3,000 to 4,000 rpm and most preferably 3,500 to 3,700 rpm.

[0075] More preferably, steps c) and e) are carried out using the same in-line disperser, preferably an in-line disperser comprising a high-shear mixer. This simplifies the setup used to carry out the process. This setup is advantageous if the process is carried out as a recycling process.

[0076] As explained above, preferably, step c) is carried out using a dosing pump. Steps d) and e) can be carried out in parallel. This makes the process even more efficient. In addition, the dispersant is distributed uniformly in the aqueous phase, avoiding effects of Petition 870250083710, dated 09 / 17 / 2025, page 66 / 82 / 29 undesirable concentration. Preferably, during steps a) and b), no dispersion is carried out.

[0077] Preferably, the process of the present invention is carried out at a temperature in the range of 15 to 45°C, more preferably 20 to 30°C.

[0078] Preferably, the weight ratio between water and the water-insoluble solid organic UV filter compound is in the range of 0.4 to 1.0, more preferably in the range of 0.6 to 0.8, and most preferably in the range of 0.65 to 0.75. Also preferably, after step d), the weight ratio of the dispersant to the water-insoluble solid organic UV filter compound is in the range of 0.4 to 1.0, more preferably in the range of 0.6 to 0.8, and even more preferably in the range of 0.65 to 0.75. These ratios ensure that foam formation is reduced and that the increase in viscosity of the dispersion is tolerable for the in-line disperser.

[0079] Preferably, the process according to the present invention is carried out without the addition of an antifoaming agent. Therefore, preferably, during the process according to the present invention, in the first aqueous dispersion, in the second aqueous dispersion and / or in the aqueous dispersion of a water-insoluble solid organic UV filter compound of the process according to the present invention, no antifoaming agent is present. More preferably, during the process according to the present invention, in the first aqueous dispersion, in the second aqueous dispersion and in the aqueous dispersion of a water-insoluble solid organic UV filter compound of the process according to the present invention, no antifoaming agent is present.

[0080] The term “antifoaming agent,” as used in this document, denotes a compound that is capable of reducing or at least partially suppressing foam formation during a dispersion process.

[0081] The dispersion produced by the process of the present invention is preferably suitable for further processing, i.e., in the area Petition 870250083710, dated 09 / 17 / 2025, page 67 / 82 / 29, regarding the production of sunscreen. For such further processing, certain properties of the dispersion are advantageous. Therefore, preferably, the aqueous dispersion of a water-insoluble solid organic UV filter compound has an average particle size D50 in the range of 50 to 100 µm, more preferably in the range of 60 to 80 µm, and most preferably in the range of 68 to 75 µm. Similarly, preferably, the aqueous dispersion of a water-insoluble solid organic UV filter compound has a particle size distribution D90 / D10 in the range of 50 to 125, more preferably in the range of 60 to 120, and most preferably in the range of 70 to 110.Not only for further processing, but also to ensure the best results in transporting the fluid paste in the process of the invention, the density of the dispersant in the aqueous dispersion of a water-insoluble solid organic UV filter compound is preferably in the range of 800 to 1,400 g / l, more preferably in the range of 900 to 1,300 g / l and even more preferably in the range of 1,000 to 1,200 g / l.

[0082] Preferably, the aqueous dispersing solution obtained in step b) comprises the dispersant in an amount of 0.001 to 0.24% by weight, preferably 0.01 to 0.2% by weight and, more preferably, 0.1 to 0.15% by weight, based on the total weight of the aqueous dispersion.

[0083] Preferably, the first aqueous dispersion obtained in step c) comprises the dispersant in an amount of 0.001 to 0.2% by weight, preferably 0.01 to 0.1% by weight and, more preferably, 0.05 to 0.07% by weight, based on the total weight of the aqueous dispersion.

[0084] Preferably, the first aqueous dispersion obtained in step c) comprises the water-insoluble solid organic UV filter, in an amount of 35 to 80% by weight, preferably 40 to 75% by weight and, more preferably, 50 to 70% by weight, based on the total weight of the aqueous dispersion.

[0085] The weight ratio of dispersant to organic UV filter Petition 870250083710, dated 09 / 17 / 2025, page 68 / 82 / 29 The solid insoluble in water in the first aqueous dispersion obtained in step c is preferably from 0.00001 to 0.1, more preferably from 0.0001 to 0.0023, even more preferably from 0.0001 to 0.0020 and, in particular, from 0.0005 to 0.0015.

[0086] Preferably, the aqueous dispersion obtained in step e) comprises the water-insoluble solid organic UV filter, in an amount of 10 to 65% by weight, preferably 35 to 60% by weight and, more preferably, 50 to 58% by weight, based on the total weight of the aqueous dispersion.

[0087] Preferably, the aqueous dispersion obtained in step e) comprises the dispersant in an amount of 1 to 50% by weight, more preferably 2 to 30% by weight and, in particular, 3 to 6% by weight, based on the total weight of the aqueous dispersion.

[0088] Preferably, the aqueous dispersion obtained in step e) comprises water in an amount of 10 to 65% by weight, preferably 35 to 45% by weight, based on the total weight of the aqueous dispersion.

[0089] The weight ratio of dispersant to the water-insoluble solid organic UV filter in the aqueous dispersion obtained in step e) is preferably from 0.01 to 0.3, more preferably from 0.05 to 0.25 and, in particular, from 0.07 to 0.11.

[0090] In aqueous dispersion, the weight ratio between water and the water-insoluble solid organic UV filter compound is preferably in the range of 0.4 to 1.0, more preferably in the range of 0.6 to 0.8 and most preferably in the range of 0.74 to 0.79.

[0091] The aqueous dispersion may contain additional excipients, such as colorants, pH adjusters, preservatives, which may be incorporated in step b) or added after step e).

[0092] Typically, the dispersion is subsequently processed in a colloid mill, with subsequent grinding in a stirred media mill. Petition 870250083710, dated 09 / 17 / 2025, pp. 69 / 82 / 29 to achieve the necessary product properties. In the case of the present invention process, the first step, i.e., grinding in a colloidal mill, can preferably be ignored, since foam formation is suppressed and the dispersion quality of the dispersion is already high enough to be fed directly to the agitated media mill. Therefore, the present invention process also has the advantageous effect that the post-process processing steps are simplified and become more efficient. Examples Measurement methods A) Particle size

[0093] Particle size was determined using laser diffraction (Malvern Mastersizer 3000, Fraunhofer model, 20 kPa (0.2 bar) feed pressure). More information on this particle size distinction method can be found, for example, in “Particle Characterization: Light Scattering Methods” by Renliang Xu, Kluwer Academic Publishers (ISBN 0-306-47124-8).

[0094] Unless otherwise stated, all particle sizes relating to the nanoscale insoluble organic UV absorber are Dv50 values ​​(volume diameter, 50% of the population resides below this point and 50% resides above this point) determined by light scattering. b) Mass density

[0095] Mass density was measured as apparent density, which is measured according to the DIN / EN ISO 60 standard. Equipment for mass density measurements is available, for example, from Landgraf Laborsysteme HLL GmbH, Germany. General experimental configuration

[0096] The following description refers to Figure 1. The inlet of a Ystral GmbH Conti-TDS 3 inline disperser was connected by a line. Petition 870250083710, dated 17 / 09 / 2025, p. 70 / 82 / 29, describes the inlet to a cylindrical container with a volume of 250 L, a height of 127 cm, and a diameter of 50 cm, which was equipped with an electric mixer and a thermometer. The Conti TDS 3 powder inlet was connected via a powder line with a powder fluidization device. The Conti TDS 3 outlet was equipped with an outlet line, which was again connected to an immersion tube reaching the bottom of the container for recycling. The inlet line was equipped with a dosing device for dispersant dosing. The dispersant used in all examples was Plantacare® 2000 UP, commercially available from BASF SE. This material is an aqueous solution of alkyl polyglycoside and contains approximately 50% dispersant.The water-insoluble solid organic UV filter used in all examples was 2,2'-Methylene-bis-(6-(2H-benzotriazol-2-yl)4-(1,1,3,3-tetramethylbutyl)phenol) (MBBT), commercially available as Tinosorb M from BASF SE in powder form. The MBBT material was a powder with a bulk density of approximately 500 to 600 g / L. Comparative Example CE1

[0097] The container was filled with 85 kg of double-distilled water at a temperature of 20.9°C. No dispersant was added to the container. The dispersant dosage was set to 20 g / s (i.e., 10 g / s of active compound).

[0098] Dispersion was initiated and set to run at 3,000 rpm. After 34 s, 120 kg of UV filter were added, after which strong foam development was observed. The temperature in the container increased to 21.7°C. Dosing was also stopped after 34 s. The first aqueous dispersion obtained had a dispersant concentration of 0.165% by weight and a UV filter concentration of 58.3% by weight.

[0099] The dispersion was further dispersed (i.e., without any additional addition of dispersant or UV filter) for 60 seconds at 3,000 rpm, resulting Petition 870250083710, dated 09 / 17 / 2025, pp. 71 / 82 25 / 29 in a further increase in the temperature in the container to 23.1 °C.

[00100] The foam produced had rough foam pores on the surface and finely dispersed creamy foam in the remaining liquid phase, cf. Figures 2 and 3.

[00101] However, the development of the foam was very fast and very strong. Comparative Example CE2

[00102] The container was filled with 85 kg of double-distilled water at a temperature of 21.1 °C. The container was filled so that the distance from the liquid surface to the upper edge of the container was 80 cm. 500 g of dispersant (i.e., 250 g of active compound) were added to the container. The dispersant dosing was set to off. The resulting aqueous dispersant solution had a dispersant concentration of 0.292% by weight.

[00103] Dispersion was initiated and set to run at 3,000 rpm. After 37 s, 120 kg of UV filter were added, after which strong foam development was observed. The foam produced had rough foam pores on the surface and finely dispersed creamy foam in the remaining liquid phase. The temperature in the container increased to 21.7°C. The foam volume reached a distance from the foam surface to the upper edge of the container of 15 cm.

[00104] The dispersion was further dispersed (i.e., without any additional addition of dispersant or UV filter) for 60 seconds at 3,000 rpm, resulting in a decrease in foam volume to achieve a distance from the foam surface to the top edge of the container of 20 cm.

[00105] The dispersion was further dispersed (i.e., without any additional addition of dispersant or UV filter) for 60 seconds at 3,000 rpm, resulting in a decrease in foam volume until a distance of 30 cm was reached between the foam surface and the upper edge of the container. The temperature Petition 870250083710, dated 09 / 17 / 2025, page 72 / 82 / 29 of the liquid was 26°C.

[00106] The remaining amount of UV filter was added over 17 s under additional dispersion (3,000 rpm), resulting in a maintained volume of foam at a distance from the foam surface to the top edge of the container of 30 cm.

[00107] The dispersion was further dispersed (i.e., without any additional addition of dispersant or UV filter) for 50 seconds at 3,000 rpm. The dispersion had to be stopped due to the very high density of the liquid, resulting in a decrease in the volume of the foam to achieve a distance from the foam surface to the upper edge of the container of 35 cm. The liquid temperature was 28°C. The first aqueous dispersion obtained had a dispersant concentration of 0.121% by weight and a UV filter concentration of 58.5% by weight.

[00108] Finally, the remaining dispersant (22 kg, i.e., 11 kg of active compound) was dosed and the density of the liquid was instantly reduced, resulting in an increase in the volume of the foam to reach a distance from the foam surface to the upper edge of the container of 27 cm. The temperature of the liquid was 28°C. A probe was removed (A).

[00109] The liquid was finally dispersed for 1 min at 3,000 rpm (Probe B, 29.5°C), for another 1 min at 3,000 rpm (Probe C, 31.2°C) and for another 1 min at 3,600 rpm (Probe D, 33.3°C).

[00110] However, since the objective was to disperse 125 kg of MBBT in 85 kg of double-distilled water, foam development was very rapid. Inventive Example IE1

[00111] The container was filled with 85 kg of double-distilled water at a temperature of 20.6°C. The container was filled so that the distance from the liquid surface to the upper edge of the container was 80 cm. 400 g of dispersant (i.e., 200 g of active compound) were added to the container. The dispersant dosage was set to Petition 870250083710, dated 09 / 17 / 2025, p. 73 / 82 / 29 is disconnected. The aqueous dispersant solution obtained had a dispersant concentration of 0.234% by weight.

[00112] First, the system was deaerated by adjusting the in-line disperser to 600 rpm. Dispersion was initiated and set to run at 3,000 rpm. After 54 s, 125 kg of UV filter were added, after which some foam development was observed. The foam produced had rough foam pores on the surface and finely dispersed creamy foam in the remaining liquid phase. The temperature in the container increased to 21.5°C. The foam volume reached a distance from the foam surface to the upper edge of the container of 32 cm at most and 36 cm after the dispersion was complete. The first aqueous dispersion obtained had a dispersant concentration of 0.0951% by weight and a UV filter concentration of 59.5% by weight.

[00113] The remaining dispersant (22.1 kg, i.e., 11.05 kg of active compound) was dosed at maximum speed while the in-line disperser was set to 3,000 rpm. The liquid temperature was 21.8°C and the distance from the foam surface to the upper edge of the container was 27 cm. A probe (E) was removed.

[00114] The liquid was finally dispersed for 3 min at 3,000 rpm (Probe F, 26.4°C, distance of 27 cm) and for a further 1 min at 3,600 rpm (Probe F, 28.6°C, distance of 28 cm). Inventive Example IE2

[00115] The container was filled with 85 kg of double-distilled water at a temperature of 20.7°C. The container was filled so that the distance from the liquid surface to the upper edge of the container was 85.5 cm. 250 g of dispersant (i.e., 125 g of active compound) were added to the container, representing 1.1% by weight of the total weight of dispersant to be added. The dispersant dosing was set to off. The resulting aqueous dispersant solution had a concentration Petition 870250083710, dated 09 / 17 / 2025, page 74 / 82 / 29 of dispersant of 0.146% by weight.

[00116] First, the system was deaerated by adjusting the in-line disperser to 600 rpm. Dispersion was initiated and set to run at 3,000 rpm. At 54 s, 125 kg of UV filter were added, at which point no foam development was observed, but rather a slight increase in liquid viscosity (which could still be processed by the in-line disperser). The temperature in the container increased to 21.5°C. The liquid volume reached a distance from the liquid surface to the upper edge of the container of 36.5 cm. A probe was removed (G). The first aqueous dispersion obtained had a dispersant concentration of 0.0595% by weight and a UV filter concentration of 59.5% by weight.

[00117] The remaining dispersant (22.25 kg, i.e., 11.125 kg of active compound) was dosed at maximum speed while the in-line disperser was set to 3,000 rpm (already during the next dispersion step, cf. below), leading to a sharp decrease in the viscosity of the dispersion. The observed increase in liquid viscosity disappeared instantly.

[00118] The liquid was finally dispersed for 3 min at 3,000 rpm (Probe H, 26.9°C, distance of 27 cm) and for a further 1 min at 3,600 rpm (Probe I, 29°C, distance of 27 cm). Summary

[00119] Comparison of Comparative Example 1 with the remaining examples shows that adding the total weight of dispersant required to form the respective dispersion results in rapid and heavy foam formation, making further processing of the liquid / foam system impossible.

[00120] As demonstrated by Comparative Example 2, even reducing dispersant to less than 0.3% by weight per aqueous dispersant solution resulted in heavy foam formation. With 0.234% by weight of dispersant per aqueous dispersant solution, foam production was significantly reduced. With 0.146% by weight of dispersant per solution Petition 870250083710, dated 09 / 17 / 2025, page 75 / 82 / 29 aqueous dispersant, no foam could be detected. Table 1: Particle sizes Probe D10 [μm] Median [μm] D90 [μm] D90 / D10 D 1.28 27.21 162.05 126.60 A 1.89 68.45 288.90 152.86 C 1.62 60.72 216.00 133.33 H 2.35 71.63 222.63 94.74 I 2.19 71.69 208.88 95.38

Claims

1. A process for producing an aqueous dispersion of a water-insoluble solid organic ultraviolet (UV) filter compound, characterized in that it comprises the steps of: a) providing water, a dispersant, and a powder comprising the water-insoluble solid organic UV filter compound; b) providing an aqueous dispersing solution by adding the dispersant to the water in an amount of 0.001 to 0.25% by weight relative to the total weight of the aqueous dispersing solution, leaving a remaining amount of dispersant; c) dispersing, using an in-line disperser, the powder comprising the water-insoluble solid organic UV filter compound in the aqueous dispersing solution, producing a first aqueous dispersion; d) adding the remaining amount of dispersant to the first aqueous dispersion, producing a second aqueous dispersion;(e) to further disperse the second aqueous dispersion, producing an aqueous dispersion of a water-insoluble solid organic UV filter compound, wherein the total amount of dispersant is greater than 0.25% by weight relative to the total weight of the aqueous dispersing solution.

2. Process according to claim 1, characterized in that, in step b), the dispersant is added in an amount less than 0.24% by weight relative to the total weight of the aqueous dispersant solution, preferably in an amount less than 0.2% by weight and more preferably in an amount less than 0.15% by weight.

3. A process according to any of the preceding claims, characterized in that the powder consists of a solid, water-insoluble organic UV filter compound.

4. Process according to any of the claims above, characterized in that the powder is added in step c) at a rate in the range of 50 to 200 kg / min, preferably in the range of 100 to 150 kg / min, and more preferably in the range of 120 to 130 kg / min.

5. Process according to any of the preceding claims, characterized in that the powder from step c) is a fluidized powder.

6. Process according to any of the preceding claims, characterized in that step c) is carried out using an in-line disperser comprising a high-shear mixer.

7. Process according to claim 6, characterized in that, in step c), the high shear mixer is operated at a rotational speed in the range of 2,000 to 4,000 rpm, preferably 2,500 to 3,600 rpm, and more preferably 2,900 to 3,100 rpm.

8. Process according to any of the preceding claims, characterized in that step (e) is performed using an in-line disperser.

9. Process according to claim 8, characterized in that the in-line disperser comprises a high-shear mixer.

10. Process according to claim 9, characterized in that, in step e), the high shear mixer is operated at a rotational speed in the range of 2,500 to 4,500 rpm, preferably 3,000 to 4,000 rpm, and more preferably 3,500 to 3,700 rpm.

11. Process according to any one of claims 7 to 10, characterized in that steps c) and e) are carried out in the same high-shear mixer.

12. Process according to any of the preceding claims, characterized in that step d) is carried out using a dosing pump.

13. Process according to any of the claims in Petition 870250083710, dated 09 / 17 / 2025, page 78 / 82 3 / 3 above, characterized in that, in the aqueous dispersion, the weight ratio between water and the water-insoluble solid organic UV filter compound is in the range of 0.4 to 1.0, preferably in the range of 0.6 to 0.8, and more preferably in the range of 0.74 to 0.

79.

14. Process according to any of the preceding claims, characterized in that the water-insoluble solid organic UV filter compound is 2,2'-Methylenebis[6-(2H-1,2,3-benzotriazol-2-yl)-4(2,4,4-trimethylpentan-2-yl)phenol] (MBBT) or 2,4,6-Tris([1,1'-biphenyl]-4-yl)1,3,5-triazine (TBPT).

15. Process according to any of the preceding claims, characterized in that the dispersant is an alkyl glycoside, preferably having the formula CnH2n+1O(C6H10O5)xH, where n is an integer ranging from 8 to 16, ex is the average polymerization level of the glycosidic fraction (C6H10O) and ranges from 1.4 to 1.6, more preferably “INCI decyl glucoside”, and most preferably the active compound in Plantacare® 2000 UP.

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