Compositions and methods of binding to t cells.

Abstract

The description generally relates to binding proteins comprising antigen-binding sites, a T-cell receptor-binding site, and a T-cell costimulatory molecule-binding site. The description also relates to pharmaceutical compositions comprising such binding proteins, nucleic acid molecules encoding such binding proteins, and vectors comprising such nucleic acid molecules. The description further relates to methods for treating a disorder or condition using such binding proteins and pharmaceutical compositions, binding proteins and pharmaceutical compositions for use in the treatment of a disorder or condition, and the use of such binding proteins and pharmaceutical compositions for the manufacture of a medicament to treat a disorder or condition.