Phage therapy

Abstract

The present invention relates to phage therapy. More specifically, the present invention relates to novel bacteriophages having high specificity for Pseudomonas aeruginosa strains, their manufacture, components thereof, compositions comprising them and their use in phage therapy.

Description

[0001] This invention relates to novel bacteriophage compositions, their manufacture, and their uses. The invention is particularly suitable for treating infections in mammals, especially those of the respiratory system. Background Technology

[0002] Bacteriophages are small viruses that exhibit the ability to infect and kill bacteria without affecting cells from other organisms. First described by William Twort almost a century ago and independently discovered shortly thereafter by Félix d'Herelle, over 6,000 different bacteriophages have been discovered and morphologically described to date, including viruses of bacteria and archaea. The vast majority of these viruses are tailed, while a smaller number are polyhedral, filamentous, or pleomorphic. They can be classified according to their morphology, genetic contents (DNA or RNA), specific host, habitat (marine viruses or other habitats), and life cycle. As intracellular parasites of bacterial cells, bacteriophages exhibit different life cycles within their bacterial hosts: lytic, lysogenic, pseudolysogenic, and chronic infection (Weinbauer, 2004; Drulis-Kawa, 2012). As a normal part of their life cycle, lytic bacteriophages cause lysis of the host bacterial cell. Lysogenic phages (also known as temperate phages) can replicate using a lytic life cycle and cause host bacterial lysis, or they can incorporate their DNA into the host bacterial DNA and become non-infectious prephages. Regardless of the phage life cycle type, the first step is attachment to receptors on the bacterial cell wall, after which phage material can enter the bacteria. This specific process affects the range of possible phage-bacteria interactions.

[0003] Bacteriophages are often used as research tools to improve bacteria in laboratory experiments.

[0004] Due to their target host cell specificity, bacteriophages have been considered for use as a therapy to treat acute and chronic infections, particularly in dermatology, ophthalmology, urology, dentistry, pediatrics, otolaryngology, or surgery. However, the concept of this therapeutic use of bacteriophages for bacterial infections has been highly controversial from the outset and has not been widely accepted by the public or the medical community. Early studies were widely criticized for the lack of suitable controls and inconsistent results. The lack of reproducibility and numerous conflicting results obtained in various published studies led the Council on Pharmacy and Chemistry of the American Medical Association to conclude that the evidence regarding the therapeutic value of lysate filtrate was largely contradictory and unconvincing, and recommended further research to confirm its claimed benefits.

[0005] Since the introduction of antibiotics in the 1940s, this field of therapeutics has received little attention, particularly in the Western world. However, the widespread use of antibiotics has led to the proliferation and spread of antibiotic-resistant bacteria worldwide, causing increasingly serious problems. Therefore, overcoming the limited remaining treatment options for treating major multidrug-resistant microorganisms has become a major therapeutic challenge.

[0006] Since its initial discovery in the late 19th century (Fordos 1859), the Gram-negative bacterium *Pseudomonas aeruginosa* has earned a notorious place on the list of infamous human pathogens (Williams et al., 1894; Freeman et al., 1916). The advent of the antibiotic era has greatly mitigated the previously fatal outcomes of acute infections in healthy patients. Only relative improvement has been achieved in the eradication of chronic infections, which primarily occur in individuals with cystic fibrosis or severe burns, or in immunocompromised individuals (Gang et al., 1999; Jones et al., 2010). Two intrinsically related factors in the lethal outcomes of infections in these patients are the rapid prescribing of inappropriate antibiotic treatment and the occurrence or acquisition of multidrug-resistant strains. Although the use of appropriate antibiotics has been reported as essential for the eradication of Pseudomonas aeruginosa infections (Kang et al., 2005; Micek et al., 2005), antibiotic abuse, on the contrary, significantly contributes to the gradual increase in resistance by exerting continuous selective pressure through the acquisition of this ability. Antibiotics alone cannot explain the high prevalence of multidrug-resistant variants: Pseudomonas aeruginosa possesses multiple intrinsic resistance mechanisms encoded by its chromosomes, including low cell membrane permeability and numerous multidrug efflux pumps. Another major factor responsible for the successful invasion and persistence of this bacterium is its high adaptability, allowing for rapid colonization in diverse environments.

[0007] Furthermore, pathogenic bacteria such as *Pseudomonas aeruginosa* can form biofilms, which contribute to their increased resistance to antibiotics. These biofilms may contain more than one type of bacteria supported and surrounded by a secreted extracellular matrix, and help bacteria colonize a wide variety of surfaces. Biofilms allow bacteria to attach to surfaces and reach population densities that would otherwise be unsustainable, providing increased resistance not only to antibiotics but also to many environmental stresses, including toxins such as heavy metals, bleach, and other cleaning agents. Bacteria in biofilms are known to be 100 to 1000 times more resistant to antibiotics than the same bacterial strains growing in planktonic form. This increased resistance means that bacteria that appear sensitive to antibiotics in laboratory tests may be resistant to therapy in a clinical context. Even if some bacteria are eliminated, biofilms can provide a reservoir of resistance, allowing for rapid colonization once the antibiotic is no longer available. Therefore, biofilms are clearly an important factor in many human diseases. Chemotherapy is unsuitable for combating biofilms because this is precisely the situation they have evolved to combat. Physical abrasion does offer a means of disrupting biofilms. Unfortunately, many surfaces that support bacterial pathogenesis, such as bones, joints, and implanted medical devices, are not well-suited for harsh abrasion. For example, the surfaces of wounds or burns are extremely sensitive and delicate. Even where abrasion is both suitable and routinely used, biofilm removal is limited. Oral plaque on tooth surfaces is a biofilm and is partially removed through daily brushing. However, bacteria remain on unbrushed surfaces (such as the crevices between teeth) and can rapidly and effectively recombine on cleaned surfaces. It is clear that existing methods for removing biofilms have limited effectiveness.

[0008] Rapid adaptability and the ability to form biofilms are the main reasons why *Pseudomonas aeruginosa* is identified as an opportunistic pathogen. They have acquired hospital pathogen status and can be isolated from clinical samples obtained from wounds, sputum, bladder, urethra, vagina, ear, eye, and respiratory tract. The emergence of resistance to the most potent new antibiotics in these clinical *P. aeruginosa* strains, even during treatment, makes the fight against hospital pathogens of *P. aeruginosa* extremely challenging.

[0009] Therefore, there is a great need for new antibacterial agents or compositions suitable for use in human or animal therapies and for sterilizing materials, which can be used to destroy Pseudomonas aeruginosa strains even in tissues with bacterial biofilms. Summary of the Invention

[0010] The inventors have isolated and characterized novel bacteriophages that exhibit strong and specific lytic activity against *Pseudomonas aeruginosa* (P. aeruginosa) strains. These bacteriophages, particularly combinations thereof, provide very potent antibacterial effects and can be used as active agents in pharmaceutical or veterinary preparations, especially for the treatment of *P. aeruginosa* bacterial infections.

[0011] One object of the present invention is to provide an antibacterial composition comprising at least two phages having lytic activity against Pseudomonas aeruginosa strains, said at least two phages being selected from phages having a genome having a nucleotide sequence comprising any one of SEQ ID NO: 1 to 7 or a sequence having at least 90% identity with it.

[0012] Another object of the present invention relates to a bacteriophage that has lytic activity against Pseudomonas aeruginosa strains and has a genome comprising a nucleotide sequence selected from any one of SEQ ID NO: 2 to 7 or a sequence having at least 95% identity with it.

[0013] The bacteriophages of the present invention exhibit strong lytic activity against multidrug-resistant strains of Pseudomonas aeruginosa, particularly against antibiotic-resistant pathogenic strains such as cephalosporinase, carbenicillinase, carbapenemase and / or broad-spectrum β-lactamase-resistant strains, and are therefore particularly suitable for and beneficial for the treatment of bacterial infections.

[0014] The present invention also relates to isolated nucleic acid molecules contained in the bacteriophages of the present invention, preferably isolated nucleic acid molecules containing a nucleotide sequence selected from any one of SEQ ID NO: 2 to 7 or a sequence having at least 95% identity with it; and isolated polypeptides encoded by said nucleic acid.

[0015] Another object of the present invention is a composition comprising nucleic acids or polypeptides as defined above.

[0016] The compositions of the present invention typically also contain pharmaceutically or veterinarily applicable excipients or carriers. These may be liquid, semi-liquid, solid, or freeze-dried.

[0017] Another object of the present invention relates to bacteriophages, nucleic acids, polypeptides or compositions as defined above, for use in treating infections in mammals, improving the microbial flora in mammals, sterilizing materials, and / or killing Pseudomonas aeruginosa bacteria or impairing the integrity of bacterial biofilms.

[0018] The present invention also relates to bacteriophages, nucleic acids, polypeptides, or compositions as defined above, for improving the condition of a subject by modifying the microbial community within the subject. The microbial community can be improved by correcting, altering, or restoring an appropriate balance of microorganisms within the community.

[0019] The present invention also relates to a method for treating an infection in a mammal, the method comprising administering to the mammal at least one phage, nucleic acid, polypeptide or composition as defined above.

[0020] The present invention also relates to a method for treating a surface or material suspected of being contaminated with Pseudomonas aeruginosa bacteria, the method comprising applying to the surface or material at least one bacteriophage, nucleic acid, polypeptide, or composition as defined above. The surface or material can be the surface of any device, container, laboratory material, clothing, etc.

[0021] Another object of the present invention relates to a kit comprising a composition as defined above and a tool for applying the composition to an object or surface.

[0022] This invention can be used in any mammal, preferably in humans, or for processing any material, including laboratory materials or medical devices. Attached Figure Description

[0023] Figure 1 Efficacy of phage 1384 against PAO1 strain

[0024] Figure 2 Efficacy of phage 1777 against PAO1 strain

[0025] Figure 3 Efficacy of phage 1792 against PAO1 strain

[0026] Figure 4 Efficacy of phage 1797 against PAO1 strain

[0027] Figure 5 Efficacy of phage 1800 against PAO1 strain

[0028] Figure 6 Efficacy of phage 1902 against PAO1 strain

[0029] Figure 7 Efficacy of phage mixture against PAO1 strain

[0030] Figure 8 Efficacy of phage mixture against CF1 strain

[0031] Figure 9 Efficacy of phage mixture against CF2 strain

[0032] Figure 10 Efficacy of phage mixture against CF3 strain Invention Details

[0034] This invention relates to novel bacteriophages, their components, compositions containing said bacteriophages, their manufacture, and their use as antibacterial agents, particularly for treating infections in mammals or improving the condition of said objects by modifying the microbial flora in said objects.

[0035] definition

[0036] To facilitate understanding of this invention, many terms are defined below.

[0037] When used herein, the term "phage" refers to a functional phage particle containing a nucleic acid genome packaged in a protein envelope or capsid. The term also refers to portions of a phage, including, for example, a head; or assemblies of phage components that provide substantially the same functional activity.

[0038] The term "phenotypic characteristics" more preferably refers to the morphology and / or host range of a bacteriophage. Methods for determining bacteriophage phenotypes are known in the past and include, for example, determining bacterial host range and / or activity against biofilms produced by certain bacterial strains.

[0039] When used in this invention, the term "lytic activity" refers to the ability of a bacteriophage to cause lysis of bacterial cells. The lytic activity of a bacteriophage can be tested on strains of *Pseudomonas aeruginosa* according to techniques known in the art (see also the Experimental Section).

[0040] The term "variant" of a reference phage refers to a phage that has variations in its genomic sequence and / or the polypeptide encoded by it compared to the reference phage, while retaining the same phenotypic characteristics as the reference phage. Variants typically contain, for example, silent mutations, conserved mutations, minor deletions, and / or minor duplications of genetic material, and retain the phenotypic characteristics of the reference phage. In a preferred embodiment, the variants of the present invention retain any observable features or characteristics dependent on the genome of the phage of the present invention, i.e., the phenotypic characteristics of the phage, and / or lytic activity against *Pseudomonas aeruginosa* strains. Preferred variants have less than 5% nucleic acid variation compared to the genome of the reference phage, even more preferably less than 4%, and even more preferably less than 2%. Alternatively or in combination, the variant preferably has less than 5% amino acid variation in the encoded polypeptide sequence compared to the polypeptide of the reference phage.

[0041] The term "ESBL Pseudomonas aeruginosa strain" refers to Pseudomonas aeruginosa strains that produce cephalosporinase and / or broad-spectrum β-lactamases, including various forms of antibiotic resistance such as AmpC β-lactamase or class A carbenicillin hydrolytic β-lactamase.

[0042] For bacteriophages, the term "specific" or "specific" refers to the type of host that the bacteriophage can infect. More preferably, a bacteriophage "specific" to Pseudomonas aeruginosa refers to a bacteriophage that can infect one or more strains of Pseudomonas aeruginosa and, under physiological conditions, cannot infect non-Pseudomonas aeruginosa bacteria.

[0043] When used herein, the term “peptide” refers to a polypeptide of any size, including, for example, small peptides of 5 to 20 amino acids, longer polypeptides, proteins, or fragments thereof.

[0044] The term "PLE" or "productive lysis effect" refers to the ratio between the burst size of a given phage and the productive lysis time. Burst size and productive lysis time are parameters that define phage-host interactions and correspond, respectively, to the average yield of phage particles produced by a bacterium infected by a phage and the time taken for a free phage to lyse a bacterial cell.

[0045] In the context of this specification, the term "isolated phage" should be understood to mean a phage that has been removed from its natural environment and / or separated from components of its natural environment. This term specifically refers to phages that have been cultured, purified, and / or formulated with any suitable diluent or excipient, for example. For nucleic acids or peptides, the term "isolated" means, for example, a nucleic acid molecule or peptide separated from at least one component of its natural environment, such as a protein, lipid, and / or nucleic acid.

[0046] When used herein, the term "pharmaceutical or veterinary" means any material (e.g., carrier, excipient, or diluent) compatible with use in mammalian subjects. These materials include physiologically acceptable solutions or media that are harmless to the organism or do not elicit any significant specific or nonspecific immune response or negate the biological activity of the active compound. To formulate the composition into a liquid dosage form, saline, sterile water, Ringer's solution, buffered physiological saline, albumin infusion solution, dextran solution, maltodextrin solution, glycerol, ethanol, and mixtures thereof can be used as pharmaceutical or veterinary excipients or carriers. Other conventional additives such as thickeners, diluents, buffers, preservatives, surfactants, antioxidants, and antibacterial agents may be added if necessary. Furthermore, diluents, dispersants, surfactants, binders, and lubricants may be additionally added to the composition to prepare injectable formulations such as aqueous solutions, suspensions, and emulsions; oral formulations such as pills, capsules, granules, or tablets; or powder formulations.

[0047] When used herein, “PFU” refers to plaque-forming unit, as clearly defined in the art. A lysing phage lyses the host cell, creating a clear zone (or plaque) on a culture plate. Theoretically, each plaque is formed by one phage, and the number of plaques multiplied by the dilution factor equals the total number of phages in the test formulation.

[0048] The term "treatment" or "therapy" refers to curative or preventative treatment of a disease. Curative treatment is defined as treatment that leads to the cure of a disease, or treatment that alleviates, reduces, stabilizes, or eliminates the symptoms of a disease or the suffering it causes directly or indirectly, or treatment that improves the condition of a subject or slows the progression of the disease. Preventative treatment includes treatment that leads to the prevention of a disease and / or treatment that reduces and / or delays the incidence of a disease or the risk of its occurrence.

[0049] When used herein, the term "biofilm" refers to heterogeneous bacterial formations grown on various surfaces; preferably, bacterial communities embedded in an extracellular polysaccharide matrix attached to a solid biological or non-biological surface.

[0050] When used herein, the term “damage” refers to any alteration of integrity. Damage to a bacterial biofilm is understood as the invasion of the biofilm by a bacteriophage, infection and / or lysis of the biofilm-associated bacteria, and / or partial or complete removal of the biofilm (i.e., by stopping colonization and / or disrupting the biofilm).

[0051] When used herein, the term "sample" refers to any sample containing cells. Examples of such samples include bodily fluids such as blood, plasma, saliva, or urine, as well as biopsy, organ, tissue, or cell samples. Samples may be processed prior to use.

[0052] When used herein, the term “object” or “patient” refers to an animal, preferably a mammal, and even more preferably a human, including adults and children. The term “object” also encompasses non-human animals, especially non-human mammals such as pets (dogs, cats), horses, cows, goats, pigs, sheep, and non-human primates.

[0053] When used herein, the term "efficacy" of treatment or "response" to phage therapy refers to a reduction in the number of *P. aeruginosa* strains in a subject following phage therapy compared to the pre-treatment number. A "good responder" subject is one who has shown or will show clinically significant improvement when treated with phage therapy.

[0054] The term "mixture" of bacteriophages refers to a combination of different types of bacteriophages. The bacteriophages in a mixture are preferably formulated together in the same container or package, although they can also be used as a kit of components, in which certain bacteriophages are formulated or packaged separately and combined upon use or administration.

[0055] Description of Implementation

[0056] This invention relates to novel phage therapy. More specifically, this invention relates to novel phages with high specificity against Pseudomonas aeruginosa strains, their manufacture, their components, compositions comprising them, and their use in phage therapy.

[0057] bacteriophage:

[0058] In a first aspect, the present invention discloses the isolation and characterization of novel phages that specifically target *Pseudomonas aeruginosa* strains and exhibit remarkable lytic activity, alone or in combination, across a host-wide spectrum. These phages are selected, isolated, sequenced, and characterized from environmental samples. They possess activity against *P. aeruginosa* strains, both individually and in combination. They are significantly and effectively resistant to pathogenic *P. aeruginosa* strains, including antibiotic-resistant *P. aeruginosa* strains such as ESBL-resistant *P. aeruginosa* strains. Furthermore, the phages of the present invention exhibit a significant productive lytic effect (“PLE”) between 1 and 7. Moreover, the phages of the present invention are specifically targeted against *P. aeruginosa* strains, i.e., they do not induce lysis of non-*P. aeruginosa* bacteria. As will be further explained, the present invention shows that these bacteriophages can be combined and formulated into a state suitable for use as pharmaceutical or veterinary agents to exhibit a targeted and very strong antibacterial effect against a controlled range of Pseudomonas aeruginosa strains.

[0059] More specifically, the following bacteriophages have been isolated. Their corresponding nucleic acid sequences have also been annotated.

[0060] Table 1

[0061] SEQ ID bacteriophage SEQ ID NO: 1 BP1384 SEQ ID NO: 2 BP1777 SEQ ID NO: 3 BP1792 SEQ ID NO: 4 BP1797 SEQ ID NO: 5 BP1800 SEQ ID NO: 6 BP1902 SEQ ID NO: 7 BP1940

[0062] The lysis profiles of these phages have been determined on a wide range of Pseudomonas aeruginosa strains. As disclosed in the table below, these phages were selected for their potency and combinatorial potential. The table shows the lysis effects of the phages on reference and pathogen-resistant strains to confirm their high lysis potential.

[0063] Table 2

[0064]

[0065]

[0066] pm: partial lysis

[0067] As can be seen from Table 2, combinations (or mixtures) of these bacteriophages can be generated that are capable of killing all tested strains of Pseudomonas aeruginosa, thereby producing broad-spectrum antibacterial compositions. As an illustrative example, a mixture of all seven bacteriophages can kill all tested bacteria.

[0068] Furthermore, the specificity of the phages has been tested on numerous non-Pseudomonas aeruginosa strains. More specifically, the experimental portion confirmed that the phages of the present invention have no lytic effect on any bacteria selected from Escherichia coli, Acinetobacter baumanii, Enterobacter aerogenes, Enterobacter asburiae, Enterobacter cloacae, Klebsiella pneumoniae, Porteus mirabilis, Staphylococcus aureus, Stenotrophomonas maltophila, and Serratia marcescens. Therefore, these phages, alone or in combination, represent potent agents for the treatment of Pseudomonas aeruginosa infections.

[0069] Therefore, a specific object of the present invention is a bacteriophage that has lytic activity against Pseudomonas aeruginosa strains and has a genome comprising a nucleotide sequence selected from any one of SEQ ID NO: 2 to 7 or a sequence having at least 95% identity with it, preferably at least 96%, 97%, 98% or 99% identity with it.

[0070] As will be disclosed in more detail below, the phages of the present invention can be cultured, amplified, isolated, purified, and used in phage therapy for diseases mediated by, for example, Pseudomonas aeruginosa. Furthermore, variants of these phages that retain the phenotype (i.e., specificity and lytic activity) can be produced and / or isolated using techniques known per se in the art.

[0071] The phages of the present invention can be prepared using standard culturing, isolation, and purification methods. For example, *Pseudomonas aeruginosa* producing bacteria are cultured, infected with a phage sample, and then treated to remove bacterial cells and debris. The enriched phage solution can be plated in a medium, such as agar, containing an embedded susceptible strain of *P. aeruginosa* to obtain plaques. Individual plaques can then be picked for subsequent phage purification and amplification. One or more selective amplification cycles of the phages of the present invention can be performed, for example, by mixing the phage with competent *P. aeruginosa*, adding growth medium, and incubating under selected experimental growth conditions. After centrifugation, the clarified amplification supernatant is filtered and another selective amplification cycle is performed or the presence of lytic activity is tested.

[0072] Subsequently, the titer of the phage in the suspension and the visualization of the plaque morphology of the phage of the present invention can be assessed by known methods, such as by plaque counting. Furthermore, as is well known in the art, the phage of the present invention can be processed into various different forms (liquid, freeze-dried, etc.) by any suitable method for short-term, long-term, frozen, or any other type of storage (see, for example, Clark, 1962).

[0073] The activity of the bacteriophages of the present invention can be evaluated using methods known in the art, such as plaque assays (also known as double agar assays), on the basis of growing the bacteriophages with potential host bacteria and then assessing their ability to kill said host bacterial cells. In the plaque assay, after incubation in soft agar medium for a period of time, the bacteriophages cause lysis of the target Pseudomonas aeruginosa strain, producing a clear zone on the plate called a plaque.

[0074] Nucleic acids and polypeptides

[0075] This invention relates to nucleic acids or any fragments of such nucleic acids contained in the bacteriophages of this invention. The term "fragment" more preferably refers to a fragment containing (or constituting) an open reading frame. The nucleic acid may be DNA or RNA, and may be single-stranded or double-stranded.

[0076] The nucleic acid may be isolated from preserved bacteriophages or produced using recombinant DNA technologies (e.g., polymerase chain reaction (PCR) amplification, cloning), enzymatic synthesis, or chemical synthesis, or a combination thereof, according to techniques generally known in the art. It also includes its homologous sequences and fragments, including but not limited to natural allelic variants and nucleic acid sequences in which nucleotides have been inserted, deleted, substituted, and / or inverted.

[0077] In a particular embodiment, the present invention relates to nucleic acids comprising a sequence selected from any of SEQ ID NO: 2-7 or a sequence having at least 95%, 96%, 97%, 98%, 99% or higher sequence identity with any of SEQ ID NO: 2-7.

[0078] The nucleic acids of the present invention can be in free form or cloned in a vector such as a plasmid, viral vector, expression cassette, or granules.

[0079] On the other hand, the present invention also relates to isolated polypeptides encoded by nucleic acid sequences as defined above, preferably selected from SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, or SEQ ID NO: 7. The polypeptides can be produced by techniques known per se in the art, such as synthesis, recombinant techniques, or combinations thereof. The polypeptides can be isolated or purified and used as antibacterial agents or as reagents for in vitro analysis.

[0080] The combination of the present invention thing

[0081] One aspect of the invention relates to compositions comprising at least one, more preferably at least two or more phages as described above, and optionally pharmaceutically or veterinarily applicable excipients. As described, the phages of the present invention exhibit very strong lytic activity against *Pseudomonas aeruginosa* strains. Combinations of these phages can be generated to expand the host range and produce highly effective antibacterial compositions.

[0082] More specifically, the present invention relates to an antibacterial composition comprising at least two phages having lytic activity against Pseudomonas aeruginosa (P. aeruginosa) strains, said at least two phages being selected from phages having a genome having a nucleotide sequence comprising any one of SEQ ID NO: 1 to 7 or a sequence having at least 90% identity with it.

[0083] In a preferred embodiment, the composition of the present invention comprises at least three, or more preferably at least four, different phages selected from phages having a genome containing a nucleotide sequence comprising any one of SEQ ID NO: 1 to 7 or a sequence having at least 90% identity with it.

[0084] The specific compositions of the present invention comprise at least: a bacteriophage having a genome containing a nucleotide sequence comprising SEQ ID NO: 3 or 4 or a sequence having at least 90% identity with it.

[0085] Specific examples of the compositions of the present invention include:

[0086] Phages having a genome containing the nucleotide sequence of SEQ ID NO: 1 or a sequence having at least 90% identity with it, and phages having a genome containing the nucleotide sequence of SEQ ID NO: 3 or a sequence having at least 90% identity with it;

[0087] Phages having a genome containing the nucleotide sequence of SEQ ID NO: 1 or a sequence having at least 90% identity with it, and phages having a genome containing the nucleotide sequence of SEQ ID NO: 4 or a sequence having at least 90% identity with it;

[0088] Phages having a genome containing the nucleotide sequence of SEQ ID NO: 1 or a sequence having at least 90% identity with it, and phages having a genome containing the nucleotide sequence of SEQ ID NO: 5 or a sequence having at least 90% identity with it;

[0089] Phages having a genome containing the nucleotide sequence of SEQ ID NO: 3 or a sequence having at least 90% identity with it, and phages having a genome containing the nucleotide sequence of SEQ ID NO: 4 or a sequence having at least 90% identity with it;

[0090] Phages having a genome containing the nucleotide sequence of SEQ ID NO: 3 or a sequence having at least 90% identity with it, and phages having a genome containing the nucleotide sequence of SEQ ID NO: 5 or a sequence having at least 90% identity with it;

[0091] Phages having a genome containing the nucleotide sequence of SEQ ID NO: 1 or a sequence having at least 90% identity with it, phages having a genome containing the nucleotide sequence of SEQ ID NO: 3 or a sequence having at least 90% identity with it, and phages having a genome containing the nucleotide sequence of SEQ ID NO: 4 or a sequence having at least 90% identity with it;

[0092] Phages having a genome containing the nucleotide sequence of SEQ ID NO: 1 or a sequence having at least 90% identity with it, phages having a genome containing the nucleotide sequence of SEQ ID NO: 3 or a sequence having at least 90% identity with it, phages having a genome containing the nucleotide sequence of SEQ ID NO: 4 or a sequence having at least 90% identity with it, and phages having a genome containing the nucleotide sequence of SEQ ID NO: 5 or a sequence having at least 90% identity with it.

[0093] In a preferred embodiment, the composition of the present invention comprises at least:

[0094] A bacteriophage having a genome containing the nucleotide sequence of SEQ ID NO: 1 or a sequence having at least 90% identity with it;

[0095] A bacteriophage having a genome containing the nucleotide sequence of SEQ ID NO: 2 or a sequence having at least 90% identity with it;

[0096] A bacteriophage having a genome containing the nucleotide sequence of SEQ ID NO: 3 or a sequence having at least 90% identity with it;

[0097] A bacteriophage having a genome containing the nucleotide sequence of SEQ ID NO: 4 or a sequence having at least 90% identity with it;

[0098] A bacteriophage having a genome containing the nucleotide sequence of SEQ ID NO: 5 or a sequence having at least 90% identity with it;

[0099] A bacteriophage having a genome containing the nucleotide sequence of SEQ ID NO: 6 or a sequence having at least 90% identity with it; and

[0100] A bacteriophage having a genome containing the nucleotide sequence of SEQ ID NO: 7 or a sequence having at least 90% identity with it.

[0101] The compositions of the present invention may also contain other antibacterial agents, particularly other bacteriophages with different host specificities.

[0102] The most preferred composition of the present invention exhibits lytic activity against more than 85% of the bacterial strains from the LMG collection obtained from the BCCM / LMG bacterial collection. This collection contains a large number of strains with high genetic diversity among bacterial species.

[0103] The compositions of the present invention may contain any effective amount of the selected phage. Preferably, they contain 10 e4 Up to 10 e12 Between PFUs, preferably 10 e5 Up to 10 e10 Each of the aforementioned phages between PFUs. The relative amount of each type of phage in the composition of the present invention can be adjusted by a person skilled in the art. Generally, when the antibacterial composition contains several (n) different phages as defined above, the total relative amount %A of each phage in the composition is more preferably %A = (100 / n) i )xV, where n iV represents the number of different types of bacteriophages, and is a coefficient of variation between 0.2 and 5. Most preferably, V is between 0.3 and 3, even more preferably between 0.5 and 2, and generally between 0.8 and 1.5. In a preferred typical embodiment, each type of bacteriophage is present in approximately equal relative amounts in the composition of the invention.

[0104] The antibacterial compositions of the present invention can be in various forms, such as liquid, semi-liquid, solid, or lyophilized formulations. The compositions of the present invention preferably contain a suitable diluent or carrier, such as a pharmaceutically or veterinarily applicable excipient or carrier. In addition to the selected bacteriophage, the compositions of the present invention may also include any excipient or carrier, such as thickeners, diluents, buffers, preservatives, surfactants, etc. These include physiologically acceptable solutions or media that are harmless to the organism or do not elicit any significant specific or nonspecific immune response or negate the biological activity of the bacteriophage. For liquid formulations, saline, sterile water, Ringer's solution, buffered physiological saline, albumin infusion, dextran solution, maltodextrin solution, glycerol, ethanol, and mixtures thereof can be used as pharmaceutically or veterinarily applicable excipients or carriers. Other conventional additives, such as thickeners, diluents, buffers, preservatives, surfactants, antioxidants, and antibacterial agents, may be added if appropriate. In addition, diluents, dispersants, surfactants, binders, and lubricants may be added to the composition to prepare injectable formulations such as aqueous solutions, suspensions, and emulsions; oral formulations such as pills, capsules, granules, or tablets; or powder formulations. Formulations for surface administration may include adhesive bandages, dressings, patches, films, ointments, lotions, creams, gels, drops, suppositories, sprays, tampons, sanitary napkins, liquids, and powders. Formulations for disinfection or for medical use may also include aerosols or sprays.

[0105] The compositions of the present invention can be used in the medical field, including human or veterinary medicine, for example, to treat infections in mammals or to improve the condition of subjects. The compositions can be used to kill *Pseudomonas aeruginosa* bacteria in organisms for the treatment of infections. The compositions can also be used to improve the condition of mammals by modifying their microbial flora. Specifically, the compositions of the present invention can specifically remove *Pseudomonas aeruginosa* strains from the skin or mucous membranes of mammals, thereby modifying their microbial flora and restoring a suitable balance.

[0106] In certain embodiments, the present invention also relates to a method for treating infections in mammals, the method comprising administering to the mammal a composition, bacteriophage, nucleic acid, or polypeptide as defined above.

[0107] The present invention also relates to the use of the described compositions, bacteriophages, nucleic acids or peptides in the manufacture of medicaments for treating infections in mammals or restoring the microbial community in said mammals.

[0108] The compositions of this invention can be used to treat a wide variety of Pseudomonas aeruginosa-mediated infections, particularly respiratory infections. In 2013, the number of patients with pneumonia reached 2 to 3 million in the United States and 3 to 4 million in Europe. Pseudomonas aeruginosa is one of the leading microbial pathogens causing these diseases, particularly in young children and the elderly, and in patients with compromised immune systems, cystic fibrosis, severe burns, and multiple trauma. Despite fluctuating epidemiological sources and despite recent increases in Gram-negative infections (including Pseudomonas aeruginosa), estimates in 2014 suggest that at least 15% of pneumonia is caused by Pseudomonas aeruginosa (e.g., 15.9% according to the ECDC Annual Surveillance Report – 2013). From a conservative perspective, about 20% of these pathogens are resistant to several or all of the antibiotics in our therapeutic arsenal (especially, the highest number of resistant cases have been observed in intensive care units). http: / / www.infectio-lille.com / diaporamas / DUAC / pyo-DUAC09-Cattoen.p df As a result, estimates indicate that at least 90,000 cases of pneumonia in the United States and at least 120,000 cases in Europe were caused by antibiotic-resistant strains of *Pseudomonas aeruginosa*. Therefore, the present invention is particularly suitable for treating pneumonia associated with or caused by *Pseudomonas aeruginosa* infection. Thus, one object of the present invention is a method for treating pneumonia in a desired subject, the method comprising administering the composition of the present invention to the subject. The method is particularly suitable for treating pneumonia caused by antibiotic-resistant *Pseudomonas aeruginosa*. The subject can be any human subject, such as a child, adult, or elderly person.

[0109] The compositions of the present invention can be administered via any convenient route, including intravenous, oral, transdermal, subcutaneous, mucosal, intramuscular, intrapulmonary, intranasal, parenteral, rectal, vaginal, and topical administration. In a preferred embodiment, the phage or composition is administered via intrapulmonary or intranasal instillation. The composition can be administered directly or indirectly, for example, via a support. In this regard, the composition can be applied or sprayed onto the affected area, for example. The compositions of the present invention can also be administered orally or parenterally. The dosage suitable for application, spraying, or administration of the compositions of the present invention can be adjusted by those skilled in the art based on various factors, including formulation, route of administration, age, weight, sex, condition, diet, route of administration, and responsiveness of the mammal to be treated. Physicians with ordinary skills in the art can readily determine and prescribe the desired effective amount of the composition.

[0110] Dosage can also be adjusted by a qualified technician to achieve lytic activity against antibiotic-resistant Pseudomonas aeruginosa strains. Depending on the route of administration, the effective dose for achieving lytic activity in vivo typically includes at least 10... e4 PFU / ml, preferably about 10 e2 Up to 10 e12 PFU / ml concentration.

[0111] As shown in the experimental section, the bacteriophages and compositions of the present invention can selectively kill *Pseudomonas aeruginosa* bacteria in vitro or in vivo. The compositions can even destroy mixtures of different *P. aeruginosa* bacteria in vivo, even at low doses. Furthermore, the compositions of the present invention can effectively kill bacteria embedded in biofilms, which is particularly important for pathogenic bacteria. Additionally, the compositions and bacteriophages of the present invention strictly do not affect mammalian cells, and are therefore specific in vivo and without side effects.

[0112] This invention also relates to the use of the compositions, bacteriophages, nucleic acids, or peptides of this invention in the disinfection of materials. Due to their potent antibacterial effects and their ability to even disrupt the integrity of bacterial biofilms, the compositions of this invention can be used as disinfectants to eliminate bacteria on materials or at least reduce their number. Such methods can be applied to the treatment of a wide variety of biological or non-biological surfaces in both medical and non-medical contexts, including solid materials or devices such as contact lenses, surfaces of devices to be implanted in the body, tubes, catheters, laboratory containers, fabrics, etc.

[0113] The diagnostic / predictive test of this invention :

[0114] The present invention also relates to a method for predicting or determining the efficacy of phage therapy in a subject, wherein the method includes the step of determining the lytic activity of one or more phages of the present invention against a strain of *Pseudomonas aeruginosa* from a sample of the subject, such lytic activity indicating highly effective treatment. Preferably, the method also optionally includes the step of treating the subject with one or more phages having lytic activity against a strain of *Pseudomonas aeruginosa* from a sample of the subject.

[0115] On the other hand, the present invention provides a method for selecting a subject or determining whether a subject is likely to benefit from phage therapy, wherein the method includes the step of determining the lytic activity of one or more phages of the present invention against a sample of *Pseudomonas aeruginosa* strains from said subject, wherein the lytic activity of one or more phages of the present invention against at least one *Pseudomonas aeruginosa* strain indicates the responder subject.

[0116] Another object of the present invention relates to a method for predicting a subject's response to a phage therapy, wherein the method includes the step of determining the lytic activity of one or more phages of the present invention against a sample of *Pseudomonas aeruginosa* strains from the subject, wherein the lytic activity of one or more phages of the present invention against at least one *Pseudomonas aeruginosa* strain indicates a good response to the therapy.

[0117] Other aspects and advantages of the invention will be disclosed in the experimental section below, which is merely illustrative. Example

[0118] Materials and methods Law

[0119] Host range determined

[0120] The host range of bacteriophages was determined from a group of 20 *Pseudomonas aeruginosa* strains from the LMG collection. 10 9 Bacterial cells were mixed with melted agar, and the mixture was poured onto solid agar to create a double agar plate. After solidification, isolated phage stock solutions were spotted onto each plate with different bacterial strains. After allowing the spotted samples to be absorbed for 20 min, the plates were inverted and incubated at 37 °C for 24 h, and the degree of lysis was then recorded (Postic, 1961; Yang, 2010).

[0121] Sequencing, analysis and annotation of bacteriophage genomes

[0122] To isolate phage DNA, the phage was propagated as described above. The phage DNA was isolated by extraction with phenol:chloroform:isoamyl alcohol (25:24:1, V / V), ethanol precipitation, and redissolution in water. Whole-genome sequencing was performed, and the BLAST algorithm was used to determine similarity to genes described in the National Center for Biotechnology Information (NCBI) database. The genome was scanned to obtain potential open reading frames (ORFs).

[0123] Example 1: Phage Isolation

[0124] Phages were isolated from environmental samples. Multidrug-resistant (MDR) Pseudomonas aeruginosa was used to isolate and enrich each virulent phage from environmental water. More specifically, environmental samples and overnight cultures of bacteria in Luria Bertani (LB) were mixed and incubated at 37°C for 24 h with shaking to enrich specific phages. At the end of the incubation, droplets of chloroform were added to the culture. The culture was centrifuged at 11,000 g for 5 min to remove bacterial cells and debris. The supernatant was passed through a 0.2 μm filter to remove residual bacterial cells. The enriched phage solution was plated on LB agar plates containing Pseudomonas aeruginosa. After incubation at 37°C for 24 h, plaques formed on the plates. Individual plaques were picked for subsequent phage purification and amplification. The phages were then stored in suspension in LB broth or physiological saline at 4°C.

[0125] The titer of bacteriophages in the suspension was estimated by plaque counting (Postic, 1961). A 10-fold dilution of the suspension was delivered to dried bacterial colonies of propagated strains. The plates were read after overnight incubation. Plaque counting also allows for visualization of plaque morphology.

[0126] Seven highly active bacteriophages were selected. Their sequences were determined and are provided in this application according to the table below:

[0127] Table 1

[0128] SEQ ID bacteriophage SEQ ID NO: 1 BP1384 SEQ ID NO: 2 BP1777 SEQ ID NO: 3 BP1792 SEQ ID NO: 4 BP1797 SEQ ID NO: 5 BP1800 SEQ ID NO: 6 BP1902 SEQ ID NO: 7 BP1940

[0129] The activity of phages, individually or in combination, was further tested in different models and conditions described in the examples below.

[0130] Example 2: Host characteristics and dynamics of bacteriophages

[0131] A one-step growth experiment was performed as previously described to first determine the productive lysis time, adsorption rate, and then the phage release amount. To determine the adsorption rate, samples were taken at different time intervals to analyze free phage particles in the solution. For determining the productive time and phage release amount, *Pseudomonas aeruginosa* bacteria were mixed with the phage solution, and phage adsorption was allowed for 15 min. The mixture was immediately centrifuged at 5000 rpm for 10 min to remove free phage particles. The precipitate was resuspended in five aliquots of fresh LB medium, and the culture was incubated at 37°C. Samples were taken at 5-min intervals to determine the phage titer. These results allowed for the calculation of the number of phages produced per bacterium (release amount), productive time, and productive lysis effect (PLE), as shown in Table 3 below.

[0132] Table 3:

[0133]

[0134] These results show that all phages possess strong viral production capacity and adsorption rates. Most phages exhibit a PLE below 7, confirming their outstanding properties. Phage 1777 is particularly effective in this regard. Furthermore, varying PLEs and adsorption times allow for the production of mixtures with selected variability.

[0135] Example 3: Bacteriophage Composition

[0136] The following mixed compositions were constructed, each containing 10 9 Up to 10 11 Each phage between PFUs:

[0137] Table 4

[0138]

[0139]

[0140] Example 4: Antibacterial activity

[0141] Various bacterial strains were mixed with the bacteriophage mixture of the present invention at a concentration of 2.10. 9 The concentration of phages / ml was incubated at 37°C for 24 h. The mixture was tested on 16 different Pseudomonas aeruginosa bacteria listed in Table 2. The percentage of bacterial species sensitive to the mixture is listed in Table 5 below:

[0142] Table 5

[0143] mixture % of Pseudomonas aeruginosa species killed I 100％ II 100％ III 100％ IV 100％ V 100％ VI 100％ VII 100％ VIII 100％

[0144] Bacterial counts were performed and used to calculate the resistance rate (number of bacteria after incubation / number of bacteria on the plate) using mixture VI. The resistance rates were obtained as shown in Table 6 below:

[0145] Table 6:

[0146]

[0147]

[0148] All the bacteria tested were sensitive to the compositions of the present invention.

[0149] Example 5: Mixture Specificity

[0150] The specificity of the mixture was verified by testing on 10 different Gram-negative and Gram-positive bacterial species, including Escherichia coli (several strains), Acinetobacter baumanii, Enterobacter aerogenes C, Enterobacter asburiae, Enterobacter cloacae, Klebsiella pneumoniae, Porteus mirabilis, Staphylococcus aureus, Stenotrophomonas maltophila, and Serratia marcescens.

[0151] Table 7 shows the loss of lytic activity in mixtures containing the seven bacteriophages.

[0152] Table 7

[0153]

[0154]

[0155] The table above clearly shows that there is no lytic activity against bacteria other than *Pseudomonas aeruginosa* strains. Therefore, the bacteriophages and mixtures of the present invention are highly specific to *Pseudomonas aeruginosa* strains.

[0156] Example 6: Efficiency of each bacteriophage against Pseudomonas aeruginosa PAO1 strain

[0157] PAO1 strain was chosen because it is a commonly used laboratory strain. The bacteria were grown individually, and each phage was cultured separately. Figure 1-6 ) or in the form of a mixture ( Figure 7 ) from 1 to 10 e-4 The MOI is added at a dilution rate of 1 to 10,000 (bacteria / phage).

[0158] Figure 1 The results show that phage 1384 is highly efficient at MOIs of 1, 0.1, or 0.01.

[0159] Figure 2 This demonstrates that phage 1777 is highly efficient at an MOI of 1.

[0160] Figure 3 It shows that bacteriophage 1792 even at 10 e-4 At the MOI, it also showed activity against the PAO1 strain for at least 6 hours.

[0161] Figure 4 It shows that bacteriophage 1797 even at 10 e-4 At the MOI, it also showed activity against the PAO1 strain for at least 6 hours.

[0162] Figure 5 It shows that bacteriophage 1800 even at 10 e-4 At the MOI, it also showed activity against the PAO1 strain for at least 6 hours.

[0163] Figure 6 It was shown that, depending on the MOI, phage 1800 was active against PAO1 strain for at least 6 hours.

[0164] Figure 7 The efficacy of phage mixture VI against PAO1 strain was demonstrated. The mixture showed efficacy even at 10... e - 4 At the MOI, it also showed high activity against the PAO1 strain for at least 6 hours and was more efficient than the phage alone.

[0165] Example 7: The bacteriophage mixture of the present invention against antibiotic-resistant Pseudomonas aeruginosa with cysticercosis. Efficiency of (P. aeruginosa) strain

[0166] Several strains were selected to represent *Pseudomonas aeruginosa*, a bacteriophage that causes respiratory problems. They were grown individually, and phage mixtures were prepared at concentrations ranging from 1 to 10. e - 4 The MOI is added at a dilution rate of 1 to 10,000 (bacteria / phage).

[0167] Table 8: Information on bacterial strains

[0168]

[0169] The results are shown in Figure 8 , 9 and 10 in.

[0170] Figure 8 The results showed that the mixture was completely effective against the CF1 strain even after 6 hours and when a very low MOI was used.

[0171] Figure 9 The results showed that the mixture remained highly effective against the CF2 strain even after 6 hours.

[0172] Figure 10 The mixture was shown to be effective against CF3 strain.

[0173] The results showed that the phage mixture VI was highly effective against three strains of *Pseudomonas aeruginosa* isolated from hospitalized patients, even after dilution up to 10,000 times. Therefore, these results confirm that the compositions of the present invention can be used for in vivo treatment of *Pseudomonas aeruginosa* infection and are active against multi-resistant bacterial strains.

[0174] References

[0175] Clark WA, 1962, Appl Microbiol. Comparison of several methods for preserving bacteriophages, 1962 Sep; 10:466-71.

[0176] Drulis-Kawa Z, Majkowska-Skrobek G, Maciejewska B, Delattre AS, Lavigne R, 2012, Learning from bacteriophages—advantages and limitations of phage and phage-encoded protein applications; 13(8):699-722.

[0177] Fordos J.1859.

[0178] Freeman L. 1916, Chronic general infection with the Bacillus pyocyaneus, Ann. Surg. 64:195–202.

[0179] Gang RK, Bang RL, Sanyal SC, Mokaddas E, Lari AR. 1999, Pseudomonas aeruginosa septicaemia in burns, Burns 25:611–616.

[0180] Jones AM et al., 2010. Clinical outcome for cystic fibrosis patients infected with transmissible Pseudomonas aeruginosa: an 8-year prospective study, Chest 137:1405–1409.

[0181] Kang CI et al., 2005. Bloodstream infections caused by antibiotic-resistant gram-negative bacilli: risk factors for mortality and impact of inappropriate initial antimicrobial therapy on outcome. Antimicrob. Agents Chemother. 49:760–766.

[0182] Micek ST et al., 2005. Pseudomonas aeruginosa bloodstream infection: importance of appropriate initial antimicrobial treatment, Antimicrob. Agents Chemother. 49:1306–1311.

[0183] Strateva T. and Yordanov D., 2009, Pseudomonas aeruginosa – a phenomenon of bacterial resistance, Journal of Medical Microbiology 58, 1133–1148.

[0184] Weinbauer MG. Ecology of prokaryotic viruses, FEMS Microbiol Rev 2004; 28:127-81.

[0185] Williams EP, Cameron K. 1894. Infection by the Bacillus pyocyaneus is a cause of infantile mortality. Public Health Pap. Rep. 20:355–360. sequence list <110> Phytosides Pharmaceuticals <120> Phage therapy <130> B1910 <160> 7 <170> PatentIn version 3.3 <210> 1 <211> 63902 <212> DNA <213> Bacteriophage P1384 <220> <221> misc_feature <222> (63895)..(63902) <223> n is a, c, g, or t <400> 1 tcgcgtttcg atgaggagat tatgccgata gtcagaatgg aagtaaagtg tctgagtgag 60 aaaaattctg cacaccgacg aacggttgtg ctcgaccgtc tgttgcggcg tcgatatact 120 cggcctattg ctaacaccgg actgattgga atgtacaaac tcaatcctgc gctgcgagcg 180 gtctggcgaa ctcgtgcccg ttacaaagtc atctatggcg gccgggcgtc ttcgaagtcg 240 cacgacgctg gcggtatag cgttttcctc gcggccaact acaagctaaa gttcctctgt 300 gctcgccagt ttcagaaccg catcagcgaa tcggtctaca cgttgatcaa ggacaagatc 360 gaaaactcag agtataatgg cgaattcatc ttcaccaaga actctatcaa gcacaagagt 420 accgggtcag agttcctatt ctatgggatc gcccgtaacc tgtcggaaat caagtccacc 480 gaaggcatcg acattctctg gcttgaggaa gctcactatc tgacccagga gcaatgggaa 540 gtcatcgagc cgaccatccg gaaagagaac tcagaaatct ggatcatctt caacccgaac 600 gaagtgaccg acttcgtgta tcagaacttc gtggtcaagc ccccgaaaga ttcctgcgtc 660 aagatgatca actggaatga aaatccgttc ctcagtgaga cgatgcttaa agtcattcac gaagcatatg agcgcgaccg ggagcaggcc gagcacattt atggcgggat tccgaagact 780 ggaggcgaca aatccgtcat caacctcaag ttcatcctcg cggccatcga cgcccacaag 840 aaactcggct gggagccagc cggatcgaag cgcatcggct tcgacgttgc ggacgacggc 900 gatgatgcga acgccaccac gctcatgcac ggaaacgtca taatggaagt ggacgaatgg gacggcctgg aagatgaact gctcaagtcg tccagccgcg tttacaatct ggcgaagctg aaaggcgcct cggtcactta tgactccatc ggcgtcggcg ctcatgtcgg ttcgaagttc 1080 gccgagttga acgatgccag ccccgacttc aaacttatct atgatccatt caacgcgggc ggcgctgtcg ataagcctga tgatgtctac atgaagctgc cgcacacgac gatcaagaac aaagaccact tcagcaacat caaggcgcag aagtgggag aagtcgcgac ccgattcagg aagacttatg aagcggttga gcatggaag gtttatccat tcgacgaatt gatttcgatc aactctgaaa cgattcaccc ggacaaacta aatcaattgt gtattgaact ttcgtcgccg cgcaaagacc tggacatgaa cggccggttc aaagtcgagt ccaagaagga tatgcgcgag 1440 aaacgcaaga tcaagtcacc gaacatcgct gactcggtga ttatgcggc cattctgccg 1500 atccggaagc ccaaaggctt cttcgacttc taaacataga aaagcccgga tcgctccggg 1560 cttcgggtct tactcggtgt ggttcctggc gctgagtgtc gacgcaacgg cctcgccgac 1620 tcccagggct tctggccgg ccgcgagcgc ttcggcttc gactcgacga tgaaatcatc 1680 accttggcca tcgcctggcg gaacctcgac cagcacggct tcttcgcctt cgaaccgcag 1740 gtcataggtc tttcgacgg acagaccgta acgagcgttg agcgcgtccc agagctgggc 1800 ctcataggtc cgcaggtctt gcagagcttt ctggtggctg agcatggcca tgtcaacagc 1860 ccgttgcagg gttcgtcca ggacgttgaa tcgcatgcga agagaacgaa tccgctcgac 1920 cacttccgca tccactacat gcctttcgat catcgctttt cacctttgct gaatgttacg 1980 ttgtagccgt tgtcggccag ataggtcaag gcgccttcga aagaagttcc gacaaggtgc 2040 ttgagctgca ttcgcgttg cgcggcgatc cagaatgccg ttccggagaa ctctgcgcgg 2100 ccttccgaca aaacctttcc atcaggcccg tcgatccgta catggacgga agatagcttc 2160 agcgccatca gtgaaccgtc cctgtgaagg cgcgcgccgc cgcgcattga tcgcaagggc 2220 actccctctg gatgcgcgcc aggtcgtttg catccagggc gtagagtttt ccatctacgg 2280 tatcgtgagc cattgcgatg tccggatatt cgttttcgtc caggccggat gccgcacgga 2340 tgttgttcca gatgccggca tgttccgcgc gatggcgcgc ggtcaactca tcttgctctt 2400 tgttcgccct ttcaacgaat ttctccagga gttcggtgaa tttctcatcg atgactcgtg 2460 cagacttgac agagctgagt cgaatcgggt ctttcttcat ggtgattctc ttttgctggt 2520 ggttgttcgc tgcccagacc tattcaaagt ctgggcagca tgatgaaaat gaacacgaag 2580 gctgcaaacg ccaatagcgt tcctgtaagc attttggctt gactctgcac ctcagcgtac 2640 tgcttagtgg acattccgtg ctgcgccgcc tcggccgcga agcgagcttt cgcctcgata 2700 acttccgggc gcagcgacag gacatattct aaggcctctt cccgcgcttt tcggcctcga 2760 ccaacctagg gtcgcgggcc gagacttcgc tgtgccctgg cctcgcggga tgggcctgca 2820 gcgatggcgg aagttcggcg gccacgactc catagtcggc gcaggcccaa gcgatcccga 2880 tgaggatcgc gaggatggat tgaacgattc gtagcatcac tttgtcgcta gggaagctca 2940 tgatcaatcc tccacagacc gaacgatttc catgttgcgg ccggcattgg tcccggcatt 3000 gaaggcgcgc cgaccgtcgc tatcgtccag acgcatgagc ttagcaacat tgtacttctt 3060 gtagccagga tcgccgaaat gttcgtgaac cgcagcttcc ttcaccacaa ccagagacgt 3120 tccggcagaa gataccagct ccatgcgctt cctggttatg gcctgaaggc gatagctgat 3180 ttcctgggtc gcggccagct tgaattgcgc ggcaaccttg acgttgaatc gtccgtatcc 3240 ttgagccttc tgatactccc ggcacagacg atcaaccgct tcgacaaggg agttgaacat 3300 gttcaccgcc agctcaacgt ccgatttgta gcctttaaag cggacggcat gaccccagcg 3360 cttcgtagtc ccgccgtttg cggcgtgcca agaagccttg gcggtcgctc ggtgatcgtt 3420 gatgccaccg gcgaaatcca tgatgaagtc gttgtacgtc gccacggcca ccgagaagaa 3480 cttcatccag ttcgggattg cggaatagta acgagtcgcg atctgctcat cgaactcttc 3540 gcaaatctcg ccggtcactt cgaagtcgtg aaggtcatat ttgtccttca gcttcttcac 3600 acgctcggct gcaatggcag cttcgtgcgg gctggaggag tcggccgcca tggcagtcag 3660 tttgcggatg cggtctttcg ccttctcgat ggcttccggg gtgaattcgt tctggtaggt 3720 catggtcggt tccttttgtc tgaagggttt cgcgtttcaa tggagctatt ttgccttcat 3780 tcagaatgga agtaaagcat tttcttccac tatttcggca ttgactggaa gaaattccag 3840 atccaatcgc ctgctaccag caggaggatg agagcggcga agaacaagac ggcggccgcg 3900 agctgtgcgc ccggcttcag cttgggatgg ctgagcttgg gctctacggg aacggccgga 3960 gcgctggcgc tgcaaacggc atctcctgga ccgtagccga tgccgcgttc acgcgcctgg 4020 agcgacacca gggatttcag atgctcggtc tgcttttgcg actcttcgta gatgccggcg 4080 acggcgaacc agagggcgaa cacgacggac gtacacacaa cccaggcgcc ggtcagcagg 4140 agggccagcg ggccgatgac gaagacggta gcagccagga cgattgcgcc gccccagatg 4200 atgaagccgg ccagaccatt ggcgatgtcg atacagaact ttttcatttg cggattcctt 4260 cggctacagg atggagggga tttggaactc tgcgccgccg agcacatcgg tgacgacttc ccagagcgtc ggcaccgacc actggtagcg gtcgaagtcg gtttcgggat cgaagcccaa cgtcacatag gaagtggcag gccatttatg aacgctacct ttccgcatga gagtcgccac gcgtccgtca acgagcgggt tcgtcttgtg cggaacgtac gcagacatcg aatattgctg 4500. cccggcgtca acaacaaatc tttgcctctg gcgcagacat acagagccca caggattcca gccgcgaccg ccgcaagcct ggcgagccga agagtgttca taaccttcgt gagtcatttc 4620. gccgaggcaa gccgagcgat cctcgtaata gttgatgttc tccatcgatc caaccagtac cagagactcg aaatcgaatc tatgatcgtg gatggccgag tgattgaagc aaagccggcg cggcaactcc gggtgccaaa catggaggcg ccctgccggg agctggactt gaatgaaccc caggccgtgc agcgtgatct tgtccttcat cgggtcatgg acggtgctca tggataatcc 4860. tcagtagcag aaatgtatgg tgagagttac gatggccaag ccggtcgccc ataggagggc gaaccaggcc atggctttga tggttatgta gatcatccga agaactttcc ggcacagatc ggtccaatgc ccatttcgat ggatgcgtgg ttggtcaact cgcgaccgca gcaggagcat 5040 tgaccagtct tccggccgta ggcgactgcc gattccatcg gcttttcaaa catcttcaga 5100 acgtcgtcat gctcagtgtc ggtgcagtcg cgactcttga tgaatttgcc attggtgatc 5160 cggccgaggt agatgtcgcc caagacgtac aagctaccgg cgttccggct gtgagcgcta 5220 gcctctttca caataacgat gagcggctcc tcgccttcgc cagccaggcg gattttcggg 5280 cgcttgatgc cagattcttt cgccttctca aacgccttct cgattccgga aatgtccaga 5340 gtcggcgcag cagcttcctg cgcggccact ttctcgcgat atttggcgag gttttcgatg 5400 gcgcgcttcg cagcagcgat ctgattttct gtcaaggagc cgtatttata caacgactcc 5460 tgaaggctct gagcgaagct gaaggaattt ccagtccacc actcgacgat gtccgggtgc 5520 gcatcttcga aggctttaat tttgaggtcg cgctcttgcg ccgcgctaca gattttctcg 5580 atgcgctttt ctgccgcctt agcacggctc ttggcgcgct gctccgggct ggttttgtac 5640 tctttgtatc caacaccgcc gcaggcgaag caggcgcgac cataagacga agggccacgg 5700 tacaggccgg tgcctgcgca tttggtgcac ttgtcgcgat acagcttcac ttccttccgg 5760 gaattcgggc gagcgcccat ggacgcgtct tccagggtct tcggcgcttc gttgttgatc 5820 gctacggtag cgaagtcgtc acccaggtct tcgaagcctg tgaacagatt ctctgctgcg 5880 ttcatatcga ttctcctgtt tggaaagttc gtttcgatga gttgactata cgccagaaat 5940 gggaaaacgg tagcactttc gcactaccgt tcgtcgggtc gcagagggtc aggctacacg 6000 gatcaactgc gacatgactg ccaggttacg ctcggcgacg cctatgatga ggttggttcc 6060 gatgtcgaac ttccaagggt cttccctgtt cttgtcgtag aacggatttc tgaacagggt 6120 ccgccatgtc tcttcagtga agaacgtttt atggtccagg tcttggtggg cgatgttgga 6180 gttgtagaat ggaacaacga cattgagcgt cgcgccgact gccatggccc gctgcaggtc 6240 tttcaccaaa tcgatgacct gggctccggt gagatgttcg aagaagtgaa atgcgtagac 6300 cgccgtcaat tcgccgtctt catacggcac tcggccgctg gcgccgtccc agttcggcca 6360 gtcgagcgat tcgacgccgg gaatcggcga attgcctgcg cccaggttta ctgcgcggcg 6420 gtgatccggc tcgatcaact gagcgatgtc gcgcttcatg ccgagtttga acaggttttg 6480 aatatccatt tttctctcca ggttgctgct agtaaatgtc gctgttgatc ttgaatccat 6540 gctcagcgcc gtcgttgtag tcatactcgg catagctgtc gcagtaatcg ttcaaatgtt 6600 gaatgatacc aagaacgtcg ttcgcggcct tgtgccgttt cgcggcgatg gtcttggcga 6660 tgctgtcgcc gacttccagg gtttcggccg tccggcggtg gatcagaaga cgactccaaa 6720 gatagagccg gacgcgacga atgatgtcgc gatggcgctc caatcgaact tccaactctt 6780 caagttcttg ctcgcgagat ttgatgactc gtcgaagctg atgaactttc agttccaaat 6840 cgtccttagt agccatattt acctcagaaa gggaaatcgt ctggaactcc aggaagctcg 6900 acgattgttg ttgagcctga tcggtctaga atgcatccga ccgagccagc cctgtgggga 6960 tagggcctac acgaactata acaggtaact tccatgacta ttcgccaggt cgatcctcca 7020 caccatctac aaattggcgg tcgcttcgac tttagttttc gttcgtccag gacggcgcgt 7080 ctgtcgcagg aaaggcagcg cgccttaacc gacgtaacca tgggtatagt cgatcattcg 7140 gatgagttca tcatcctctg attctctcga cttcagaccg cccaaagagt ccgactggcc gtagcatttc gcatcgatat ccatcgaaga caggaatcct gccgatactg cggagatatc 7320. aactttgtcg ccggccttct tgaaaccttc gcactcagca tcaagggcca caatcgcact cgcggccatg ttcgcatgac ttatgaggtc ggggaagatc acaggaactt cacgcgacat gccacggacc gtcatcttca ggactacata cttcatactc actatccctt ttgtatgtga 7440 ggaagaatt tgctgttttc aggatggtgg aagcgctcgg ccgcaggcgg tctttcttcc 7500. ggacattga tcgtcgaagg cgggaaaacc gcgccggcga taatcgccgc gaggagtgca gcggatgtcg acatccagag ggcggtttcc aggctcaccc gaacttccgg acggcgcggc 7620. ttcattcgct ccaccctctt cccggttcat aggatggtag actgccgccg cgaacccagt 7680 tgtcccacat atggttcaga ccagtcggtg gctggggcgg cgaactgtag aatccgggag 7740 tctcagtgct gctcaggaa taggtgc aaacggcctg gacggccagt tggtgccgct cccacatctt atcaatcgct cttagcatga cgtcttcgca ctgagcctta ctgtcgaacc gtctgctagt atggtccggt atctggacac atccgtctcc agtgcaaagg aaagcagtag 7920 caatccatac ggtgatactc gccatttcgt caccctcttt agttgatgag cagagtctat 7980 tccatctgct cgccaggagt aaagcgcttt tcgtcgggat aaatgccgat gatgtctgcg 8040 tcgagcatcc aaatgtccac ggacggatcg tcgctgctga tttgatatag gttgtacagc 8100 tcccgtccgc cgacagcacg ctcgcctcgc ggctcaaccg ccagaacctt gccatgtcct 8160 tctccgtgct cgtccaggta tatgacgtga tcaccgactt catagctttc ttttgtaacg 8220 aggcgtgaac gcgagctgtt ctgcgattcc actacccagg aatccagcac gccgcctttc 8280 atgtcgcgaa acaatcttgc cgatttgtcg caatcgaata cgcccagaac ttcgccgtct 8340 ttcaacacga tatgtacgat tggcaaaaga gtattcatgt ttaatctcca ttggttgata 8400 attagagtct aatctgccga aaagttcccg taaagaatta ttttctcata actgattagt 8460 tgcaactgtt aacctgatgt atatgtttga atctcttttg aacgtttgat gtttccccta 8520 taataagcgc acacagccaa caaccacgtg gaactacaat gtttaaactt tcctggatat 8580 tcgggcgcaa aaaggataat gctgcctgtt ctgaatcggc gccggagaaa gtcgcacaaa 8640 tccctcagca cgatccgctc gaccccatga tcaagctggg aaggattcgc ggctggaacg 8700 tcgagccgga gaaagccccg gtaattcgta gcgtgaaaga tttcctggag ccgggcctat 8760 ctgtagcaat ggatagtgcg tatggtgatg gaccaactcc ggcagcgaag gctgctgcgg 8820 gcggccagaa tccctatgta gtcccgacta tgttgcagga ctggtacaac tcccaagggt 8880 tcatcggata ccaagcttgc gcaatcattt cccaacactg gttggtggac aaagcttgtt 8940 ccatgtctgg ggaagacgca gcacggaacg gatgggaact caaatcggac ggcaggaagc 9000 tatccgatga acaaagcgcg ctgatcgccc ggcgcgacat ggagtttcgc gtcaaagaca 9060 accttgtcga actcaacaga ttcaagaacg ttttcggcgt tcgcatcgcg ctgttcgttg 9120 tggagtctga cgatccggac tattacgaga aaccgttcaa cccggatgga atcacacccg 9180 gctcctacaa gggaatctcc cagatcgatc catattgggc gatgccgcag ctcactgccg 9240 actcgacggc cgatccgtct tccgaacatt tctatgagcc ggacttctgg atcatcagcg 9300 gtaagaaata tcaccgaagt cacctagtag tcgttcgcgg accgcagccg ccagatatcc tgaagcctac atacatcttc ggcggcatcc cgctcaccca gagaatctat gagcgcgtgt atgcagcgga acggacggcg aacgaagccc cgctgcttgc catgtcgaag cgaaccagca ccattcacgt tgacgtggaa aaggccatcg cgaatgagga cgctttcaat gctcgcctgg cgttctggat cgccaaccgt gataaccacg gcgtgaaagt tctgggaatt gacgaaggca 9660. tggagcagtt cgacacgac ctggccgact tcgacagcat cattatgac caatatcagc tggtcgcggc catcgccag actccagcca cgaagctcct cggcacttct ccaaaaggat tcaacgccac tggtgagcac gaaacgattt cttatcatga agaactggag tccattcaag agcacatatt cgacccactt ctcgaacgtc actatttgct tctggcgaag tcggaagaaa tcgatgtgca gctggaatc gtctggaatc ctgtagactc cacgtccagc cagcaacaag ccgaattgaa caacaagaa gccgctaccg acgaaatcta catcaactct ggcgttgtgt ctccggatga agttcgcgag cgtctgcgcg acgatccgcg ttccggctac aaccgactca 10020. ccgacgatca ggcagaaacc gaaccgggca tgtctccgga aaacctggcc gaattcgaga 10080 aggccggtgc acagtcggtc aaggcgaaag gcgaagccga gcgagccgaa gcccaggcgg 10140 gagccgtaga gggcgcaggc ggcccggttc ccgccgctcc acgcgcgact aagcctctcg 10200 cgaaggcggc cgaggaaggg gccagcgagg ccgctgaacc gccgtcgcgg ccggacccca 10260 aggccgagct gcggaacttg ttggtcgatc ttttgtcgaa gctccaagac ctggacgaca 10320 ttaaggcgcc ggacggcgta gacatagagc acaatgatgc gcctggctta aagcgcacgt 10380 ccaaacctgg cgtgtctggc atggagcctt cagtgttttc gtccaaccgc atcgtcgggc 10440 ctcgtgatca ttcggaactc cagagaatca aggtgaatgg aataaccacc ttgatcgaaa 10500 atccgcgcgg aagcattcgg caaggaaagg atgggagttg gcgagttcag atgaaacacc 10560 actatgggtt catcaaggga acgaaaggcg ctgatgggga tgaagtcgat tgcttcgtcg 10620 gtccgaatct gggatccaaa cgggtcttcg tcgtcaacca ggtgaacaag gaaggtcagt 10680 10740 tgtcatgctt ccgcccaggt tgggatggtc tcggctccat ccatgaagtt gacctacccg 10800 ctttccgtcg ctggctggcg aacggcgaca caccaaacc gtttggaggc gagtgatggc 10860 attcaaggcc tccaaaagc gcgaacgccg ggcaccttt ccggtcggaa gagggaagcc 10920 cataattcca tcggcaggaa tcgaggcctg gtacgaaag cagatgaagg atatttccaa 10980 gctcatgatc gccgactatc gaagcgagat tgagaggca ctgtcccagc ctgcggccga 11040 acggttcttc gccagcgacg aatccgttaa cgtcctgttc aagatgaccc ttcgaagcct 11100 acagcagcga tggagccgca ttttgaag ttcgcggcc aagatcgccc cggagttcgt 11160 caccggacc gagaagccg ccactcccgc gacctcac agctgtcgg tggccggcgt 11220 cgatcagcca cgagctgcgt atatgagag cgtcaggaac accctggagg ccgcaccaa 11280 ttacaatcat actctcatca ccagatcca agaggaagtc cacgagaga tttacacatc 11340 agtaatgctg tcttgactt ccccgaatcc ggaagagca ggaacttccg gcataactaa 11400 cgcacttcgc aaagtcggga agttttctga agatcgaatc gaactcatcg caagagatca 11460 aaaagcaag ctttacagtt ctctgagcga tgagagaatg gcggaaaatg gagtcgagga 11520 gttcgagtgg ctacactctt ctgccggcaa gactcctcgc cacacccacc tggagaaaga 11580 tgggaagaga ttcaagctga atgaccccag actttgggag ggtccgaaag cagaccaggg 11640 gccgccagga tgggcgatta actgtagatg cagaaagata ccagtcattt gacatcgata 11700 ggagcgctat atgccgttag ttcatggcac ttccaatgag gctcgttctg aaaacatcaa 11760 gcgggaaatc gaagccggta aggacccaaa gcaggctgcg gccatcgctt actccatcca 11820 gcgcagtgag aaaggaa cggcgaaaga ttgttcgcct gagctcgtcg ccgatcttcg 11880 cgccctggtg gactctctgt cgaggctcgt gaatgaacc gcaagacgtg ccggcgccga 11940 ctcgtggtcg atgtaatcag ggccaatatt cacggcggat tcttcagcct gaagtttgcc 12000 gccatcgatt tggcaatcat cggcgtcgcc atcttgatgg cttttggccg ataatgctga 12060 gaaaatctgg attctgacta aaaattctag tccggatagc cgcaagttac cgtttacgga 12120 aaatagcagt aatttggaaa gcctactgcc gcgaggcttt aacagagcca gttcctaatt tccgatttag ccgcatgctt caaaagtata tagcctgtga aattagt aacgttacaa tag ctatatag cgttatata tag ctatatgctc tagcgtatt gaaattcaat ttttaatcgg taattggta atttgaatta gtttagaagt tgaaagtctc gcggcagtag gcttagacaa atcccgtcaa gtttccgaga ccaaattacc ggattttcgc ggctgagga actggtaatt agatcataat acaattata atgtaagtta acagtcgcgg ctacatctaa ttattgttcc gcttatttac ccttggatgt actgcgtata fathercagcc atagtccacg actcttcga ttaacgatgg caaagtcga aagaaaaatt gacgaaaatg gatatatgac catcgagggc tgcccgatca gctcttatgg cgttttccag tattctgctg gtcaactcgg tcttccgggc gatccgacgc ggattgtcaa cgtatatcgc ccggagtctg ccgtcagcga tccggagtac atcgaatctc tgaagaatct cccgttgatc gacgagcatg agatgctgtc gggattcgac gacgatgacg acagtgtggc ccccgaagac aaaggggtgg 12840 agggcatcat cacatccaac gcttactacg aagccccatg ggcacgcggc gatatccgca 12900 tctattcccg caacatgcag aatcagctgg aaaggggcaa agaagacctg tccctaggct 12960 atagttgccg ctacactgag caacccggca tctggaacgg aacgccttat gaagtcgtcc 13020 aggacaagat gcgcggcaac cacattgccc tggtaaaaga gggtcgtgtg ccgggggcca 13080 gagtattgga tggtctgtgt tttgaccatc tcagttttga tttcagacca tccgatgagg 13140 gtaatgaaat gagtctcaag aaagccaagc ggaagccccc tgtccagcgc gtagggcaag 13200 ctgctgactc ggcggtcgaa gagttgcgcg ccctgtggcc gaagctatct gcgtctgtcc 13260 agaagttcct gggcgaagaa gagcaggagc cggagcatca ggaaggcgca gctccggccg 13320 aaccgaccga cagcgagcac ctgaccgagc atccgactct ggaaggtgcc cagaaggatg 13380 acgaagagca ggaagaggag ccttccgttg tcgatccggc cgtggccgcc gtcgagccgg 13440 agcatcaaga aagcgccgca tccgaaatgt ccggtgaagg cgaagtcgcc gaactgatct 13500 ctcaggtcaa agccattctg gctcgactgg agggcacggt agccgaaggg gcagacgaag 13560 agcatggcga aggtcaagat gtcgtcgagg gcttggagga gcagagcagc ctcagcggct 13620 cgcaaaccgc cagcgacgat ggtggtgaga gcaaggataa cagcgaggaa cttcctgaaa 13680 tggcacagaa gaacgcgcaa gatgctgcaa ttcgcggtct ctatcgcgac attgctgcta 13740 aagatcgcct ctacaagcgt cttagctccg tggttggtgc gttcgatcac cgagctatgg 13800 actcggctga agtcgctgtt tacggcgtga aaaagctgaa catcagctgt gcgaagggcc 13860 aggaagctct ggcgctcgac atgtacctga aaggcgtcga agcctcgcgc ggcgcggcca 13920 gccgtcaatc gaaagcccag gattcggccg gttctgctcc gcagtgcgcc gagctggaca 13980 gctacctgaa gggggagtaa ctcatgttcc agaaacaagt ttaccgccag tacactcctg 14040 gttttccggg cgatctgatc gaggacggcc cgaagcgggc gcggccgggt cgaatcatgc 14100 ctctgtctgc cgtaaatccg gctgccaccg ccaccggccc caaccgcatc agtcgcgctt 14160 tcggttacgc cggtgacgtc agcgccctcg gcgaaggtca gccgaagacc atcgcggctc 14220 gcgcttctga agtcgtgatc ggcggcgcca acttctttgg tgtcctcggt catccgaagc 14280 actatgcgct gttcggttcg gccggagact ccctggctcc cagctatgat ctgcccgatg 14340 gcgccgaagg cgagttcttc gacatggcca ccggcctggt cgtcgaaatt ttcaacggcg 14400 ccgcaaccgc cctggacctg gactatggtg acctggtcgc ctatgtacca aacaacctgc 14460 ctaccgccga caacgcgctt ggcctgccgg ccggcgccct ggttggcttc aaggctggct 14520 ccatgccgac cggcttggtc cagattccca acgcacgcat cgttaacgcc atcagtctgc 14580 cggcccagtc ggcggggaat ctggttgctg gcgttaccat cgtccagctc acgcagtaag 14640 gaggcgtcat gagccagatc agcaagaccc attcgcgcct cgcaggccgc aatgcgaaac 14700 ctttcgacct gaaaaacatc accaatgacg ccgtggcgtc tctgcgccgc atcggcctgg 14760 tattcgatca cgccgtcgtc caggaccaga tcaaggcctt ggcgaaggcc ggcgcgttcc 14820 gctccggctc ggccatggac agcaacttca ccgccccggt gaccacgccg tccatcccga 14880 ctcccatcca gttcctgcag acctggctgc cgggcttcgt gaaggtcatg accgctgcac 14940 ggaagatcga cgaaatcatc ggcatcgata ccgttggctc ctgggaagat caagaaatcg 15000 tccagggcat cgtggagccg gccggcactg cggtggaata cggcgatcac accaacatcc 15060 cgctgaccag ctggaacgcc aacttcgaac gtcgcaccat cgttcgtggc gagctgggta 15120 tgatggtggg caccctggaa gagggtcgtg cctcggccat ccggctgaac agcgccgaaa 15180 ccaaacgcca acaggcggcc atcggtctgg aaatcttccg caacgccatc ggcttttatg 15240 gctggcagag cggcctgggc aaccgcacct atggttttct gaacgatccc aacctgccgc 15300 cgttccagac cccgccgagc cagggctggt ccactgccga ctgggcaggc atcatcggcg 15360 atatccgcga ggccgttcgc cagctgcgta ttcagagtca agatcagatc gatccgaagg 15420 cggaaaagat caccctggcc ctggccacca gcaaggtgga ctacctgtcg gtcaccacgc 15480 catacggcat ttcggtttct gactggatcg aacagaccta tccgaaaatg cggatcgtgt 15540 ctgctccgga actgtcaggc gtccagatga aagcccaaga gccggagagat gctctggtgc 15600 tcttcgtcga agacgtgaac gcggccgtcg atggaagcac cgatggcggc agcgtgttca 15660 gccagctggt agagcaag ttcatcaccc tgggtgtcga aaagcgggcg aagtcgtatg 15720 tggagaactt ctccaacggc accgccggtg cgctgtgtaa gcgtccgtgg gccgtggtgc 15780 gctacctcgg catctaaccg atgcctattc accaaaggcc gggtttccgg cctttgttca 15840 ctctgactct gactcggttg taggggccgg ttagggcata attactagga ctacgccaat 15900 gactgtttac atcgtttccg ccatgactca atccgtgtct tacaatgcgt atgacacctc 15960 tgatccgtcc aatcctcgcc tccagcgaaa gattctgatt cgtggccgcg ccggcatcgc 16020 atccgaaact tccggcttcg gcgacatgat ttccgacgcg gccgggcgtc cgatctggac 16080 cccgcagggc gattgcactg ccgtgagcga ttcggattttc gagctgcttc aggcaataa 16140 gattttcatg cgtcacatgg ataagggcta tctgcgagtc gtgaagacag acatcaccag 16200 tgaccaccag cggattgcca aagagactcg caccatggag cgcgatggat tccagcctct 16260 ggacgctgct cgtttgcagc agaaaatcaa ggttaccacc gccagcgctt cccaggaaca 16320 agagttccgg atttaaccga gggtttcggt atggtgattt tcgacgaaaa taagtttcgc 16380 acgctgtttc cggagtttgc tgatccagcc gcttatccgg acgtgcgcct gcagatgtat 16440 ttcgacattg cgtgcgaatt catttctgat cgcgattcgc cataccggat tctcaacggc 16500 aaagccctgg aagcatgcct gtatcttctg actgcccacc tcctgtcgct gtccacgatg 16560 caagttcagg gcgcggctgg aggtggcgtc acagcaggtg ggactcaagg cggtttcatc 16620 accagcgcta ctgtcggcga ggttagcgtg gctaagctcg cgcccccggc caagaatggt 16680 tggcagtggt ggctgtccgg gacgccttat ggccaagagc tgtgggcgct cctcagcgtc 16740 aaagcggtgg gcggattcta catcggaggt cttccagagc gccgaggctt ccggaaggtt 16800 ggaggaacgt tctggtgatc cctggtgcga atcttctgcg aatggccttc ggggtcatcg 16860 gtactcaaat tgtgaaatat cgcaagtttg agcagcgagt gaagaatgat caagctcagt 16920 acgtttccat gttcgaggag cctttcgacc tggcagcgtc tgtccagcga gtccgacgcg 16980 atcagtatgt ccagtttaat ctggagttcc aacggaatta tgttatgatc ttcgccaact 17040 ttgagatggt tgacttggat cgcgatgtgg ccggtgacca gttcctctgg accggaagag 17100 tttttcagct ggagtctcaa ggctcctggt tttatcaaga cggctgggga gtttgcctgg 17160 ccgtggatat cggtgcggcc aagctcactg atgacgggaa accgactttc taggtgatgt 17220 atgtttgacg gcgaactgat agcgaaaatg gttgtcgagc tgaatgcggc gatgacatct 17280 gctcaagagg ctttgcagtt cccggatttt gaagtcgtcc agaaagctca gccgacccaa 17340 cagggaacgt caaccaggcc gaccatcttt ttccagaaac tgtttgacat tcctcgcggc 17400 tggcctgcca ccgattggca cctggacaac aaggctcgca aatatgtaga aataactcga 17460 cagcatgtag agacgacttt ccagattagt tcccttcatt ggcagaatcc tgaaataact 17520 cacgtggtta cggcttccga tatcgccaac tatgtgaggg cttatttcca agctcgatcc 17580 acgattgagc gcgtaaagga actggacttc ctcattcttc gcgtgtctca aatttccaac 17640 gaagcattcg agaacgataa tcaccagttc gaattccacc caagttttga catggttgta 17700 acttacaacc aatatattcg cctgtacgaa aacgcagcat attcggccga tggggtatta 17760 ataggcatat gagtctgagg cgcgattcag aactaatcgc cgcgcacctc cagatgttaa 17820 gagccatgcg cggcaggtcc gtttcggccg gatggtattc cacggctcga tatcctgaca 17880 aggcaggcgg atcggtcgga atacaagtcg cgagaatcgc acgtctcaat gagtacggcg 17940 gaactatcga ccatccgggc gggacaaggt atattaggga cgccattgtt cggggccggt 18000 ttgttggcgt tcggttcgtc agaaacgact ttccgggaga aaccgaggta actaagcctc 18060 acagaattac catcccggct agaccgttta tgcgatatgc ttggaacttg ttttccgcag 18120 atcgcgccgc aatccagaac cggatagcca tgaggctggc cagaggacag atcactccag 18180 atcaagctct tgcccagatc ggcctggcgt tggaaggata catagccaga agcatcagga 18240 ccgggccatg ggtggctaac tcagcatcta cggtcaggag aaagggattc aacagaccgc 18300 tggtcgatac ggcgcacatg cttcaatcga ttagcagcag agtaacataa ccaggagatc 18360 atccagtgat cagtcagagc cgttatatcc ggatcatttc gggcgtaggc gcaggcgctc 18420 cggtcgcagg ccgaaagctg attctgcgcg tcatgactac caacaacgtc atcccgcccg 18480 gaatcgtcat cgagttcgac aacgccaacg cagtcctgtc atacttcggc gcgcagtcgg 18540 aagagtatca gcgggctgcg gcttatttca agttcatcag taaaagcgtg aattcgccgt 18600 ccagcatcag cttcgctcgc tgggtaaaca ccggcatcgc gccgatggtt gttggtgaca 18660 atctgccgaa gaccatcgcc gatttcgccg gcttctcagc aggggttctg accatcatgg 18720 tcggcgcggc cgaacagaac atcaccgcca tcgatacgtc cgctgcgact tctatggaca 18780 acgtggcgtc gatcatccag accgaaatcc gcaagaacgc cgacccgcag ctggcccagg 18840 ctaccgttac ctggaatcag aacaccaacc agttcacctt ggtcggcgcc accatcggca 18900 ccggcgtcct ggctgtggcg aaatctgccg atccccagga catgtccact gccctcggct 18960 ggtccacctc caacgtcgtc aacgtcgccg gccaggctgc cgatcttccc gacgcggccg 19020 ttgccaagag caccaatgtc agcaacaact tcggttcgtt cctgttcgcc ggtgcgccgc 19080 tcgacaatga ccagatcaag gccgtgtcgg cctggaacgc ggctcagaac aaccagttca 19140 tctacacggt cgcaacttcc ctggcgaacc tcggcactct tttcaccttg gtgaatggca 19200 acgccgggac cgccctgaac gtgctgtcgg cgactgctgc caacgacttc gtggagcagt 19260 gccccagcga gattctggcc gccaccaact acgatgagcc gggcgcttcg caaactaca 19320 tgtactacca attccctggc cgcaacatca ccgtttccga cgataccgtt gcgaacaccg 19380 tcgacaagag ccggggcaac tacatcggcg tcacccaggc caatggccag caactcgcgt 19440 tctaccagcg cggcattctg tgcggcggtc cgaccgatgc ggtggacatg aacgtctatg 19500 ccaacgaaat ctggctgaag tcggctatcg ctcaagcgct cctggacctg ttcctgaacg 19560 tcaatgcggt tccggcgagc agcactggcg aggcgatgac cctggcggtg ctgcagccgg 19620 ttctggacaa ggcgacagcc aacggcacgt tcacctacgg caaggaaatc agcgccgtcc 19680 agcagcagta catcacccaa gtcaccggtg atcgccgcgc ctggcgtcaa gtccaaaccc tgggttactg gatcaacatc accttctcca gctatacca cagcaacaca ggcttgaccg agtggaaggc caattacacg ctgatctatt cgaagggcga tgccatccgc ttcgtcgaag gatcggatgt gatgatctaa tggtttgcgg cggactcgat ccgccgcgac cttccataaa tggagtgagg grandfather gatcaacatt tctgcgttcg gctcgatctg ccagttcacg gcaagtagaa ctttcccgaa cggattcacc gtcaccgagt ttgccgacga tgcggacccc atcgacagcc cgccgttcac tgcggccgat accggcgtcg gcctcaacgg tgacatggta gtctggaacc gggcgaacat cctggaagtc gtcgtcaacg ttatcccgaa caccgagggc gagcgcaacc tggcagtcct tctggatgcc aaccgcaccg gaaaggacaa gtcgggcgct 20280. cgtgatgtcg tcggtttggt cgtggcgatg ccggacggca gcaaaatcac ctgcaccaac ggcaccccaa tcgacggcgt tctgatcaac gcggtggcaa gcgtcggccg tctgaagacc aagccgtatc ggttccgatt tgaaaaagtg atcaaagccg gtactagctg atgaagaaaa ttccgctgac agcagtcccc aatcaagcga tctcatttaa cgccggtagc agctattgga 20460 agattcgcct gtaccagaac atggacatga tgaatgccga tatcagccgc gacggcgtga 20520 tcgtttgcca tggggtccgc tgcttcggcg ggattcctct tctccagtac agccatcagt 20580 accgacctga ctatggcaat ttcgtcttcg accgcgacgc cgattggaca ttgttcggcg 20640 acggcatcaa cctgttctat ctggacggcg ccgaattcgc cgagtatcag gcgcttgcca 20700 cgaggaaaga atgagcacat caacgatcag aaccgggacg aacaacgata tccttttgga 20760 cgacaatgga aacatggtta tcctcaggga tgtcgaagcg tgcgcccagg acgttcgggc 20820 ggcgatgctc atgcgcaccg gcgaaaacat tttcgatgtg aactccggcg tgggatattt 20880 cgaatacatc ttctcgccgc agaaaagcta tgatgacgct cgcaaatcca tcgcggacgc 20940 aattttatcc tcaccggatg tgaccggcat cgagcagctt gacatcgaca taaccgggga 21000 agtcttcggc gtcgatgcga aagtcatcac catccacggg cctgttacca caggagtttg 21060 aaatgagtac catccgcatc caatacgcca acggcaccca actgttcctg gacggcaaaa atccgccgcc cctggacccg ctaccctcgt ttaacccgtc tgtcgaagat ctggaaggcc 21180. tggaccgcga aaagaacacc gacaagggcg actcctctcc ggccggtctt cccgttcccc cggtaaacgt cgattcagat gtcgacaacg gcggaaccat cccggctccg gtatcgaccg acgctgctgc ggccgaatcg gccccggaag gcgcccagga agctcctgca gcaggccaag 21360. gcgacgaga aggcgccgag gagccccga ctacagcccc ggtagaaaag gccgaggaa cggcctcgcc ggccgctgaa gaggaaaccc cggctcccgc caatgccacc tctcgcaaaa ccaccagca gtaaggactc gacatgatca acgtcagcgg cttcggcacc ggaattgtaa tagtttccgc ctcatcgttc ccgatggggt tttccttgtc gaagttcgct gatgatgaga 21600 gtccgatatc ctccaaagag ctggagccgt tcggatatga gatgctttat gacggtggcc 21660 tattcgcctt tgacaaggct gctcctctgg aagtatctgt atccgtcatc gcagggagcg aggatgat taaccttcgc atccttctca attccaaaaa gggatcattc agatttcttc cgggaatcat cccggacatg acgactctcg tggccactct tcctgatggc ggccgcaccg 21840 ttctgtccaa tgggactatc atcaagggtc cggccatcga caccatacag aacaccggac 21900 gacgcaaagg caacacgtac acttttgttt tcggtagcta tcttggcgcc cagactgctc 21960 gtcaagccat ttctaacgtt atccaatcgg tactggaggt ggtctgatgt tagggatttt 22020 caccagcctc ctaagttcgc gatctttttc gattgtggac caaaacacaa accagctagt 22080 tgctgcggat ttgaggataa gccgggtcaa cacccggttt tcttctgtag ggcaacgcca 22140 catgctggaa gatggtacga ccaagatgga ttccagaacg atccacccta tggaaatcat 22200 cgtcgaagta ttttgccctt caattgatgt cgtcgatcag atcaatcaat tgctcctgga 22260 tcgcgacaca ctgtacaaag tcatcactcg cggcatggta ttcgaacgga tgatgtgtac 22320 cagcgaagcg ctcaatcaga ctccggatat gatatcggcg actcctgcgc ggctgacatt 22380 ctcccaagtt ctcgtccaga atcccaagcc tataatgttc agaaatgcag gggactcttc 22440 tatgatcgac cgagggctgg ccctagctga agacgtggtt ggctcggccg gcgatctgtt 22500 cgactacgca gtgaacggcg tccagaacgc cgcagacttg ttctgaggtg ccaattgaac 22560 tctttcctca agtctattct caacacgcct actctcacca tacgcgatga tgtcaccaaa 22620 cttcctgtct ggaagagtct tcaagtcaag aaagtggaaa tttactcgcc ggcttccgta 22680 gtgtcgaaac ctctggcgac gaaagaccag acggaagctc aagtgtacac cgaagctctg 22740 gacattgatg tgaagaatgg aaagatcatc caaccggtgc gactccgcat caatgctatc 22800 tgtccggacc tgtccaccgt tgaaagtatc atgaacgctt tcaatgataa cacctcgact 22860 ttcgctatca cttctaagtc gatattggcc gataaaatgg ccatcatgac gctcgatgta 22920 gatcagtcgc cagacatgtt gaacgcggct gagatcaata tggaattcga gcaggttgag 22980 cctccagtat tgaatgaatt cgatcctgcg ttccctcaag atagtccgac ttatggggta 23040 cagattcaat ctctttctga tgctaatttg ctggatttgg gcgccatcgg cgattcgata 23100 tcttcggccg caaaatcgct atataatcgc gtgaccagct acttctgagg atgtatcatg 23160 cttgaaatca atcttcccga tggccgtcaa actcgcgtac aaatcgaggc gtggtcggca 23220 ttggatggct gggaactcca gcgccgtttc gtcgaattcg ctgtcagcca agattccgac 23280 ttccgccgct ctttcaccat ggaaatcctg ggctatgcga aagtgctgct tggcgacgac 23340 gacaccggta ttccgctgac cactgcggcg gtcatcaaca accacctcgg ccactggaag 23400 aacgtggaac tggttttcaa ctctgttctc aagcacaatg gcatcgaccc ggccacgcac 23460 gccgaccggc cggactattg ggaacaagtc ggatcgcaga tggccatcgc atttctggcc 23520 gaggcgtcca agctcattgg tccagcaatg aagatcgccg aaggactcgc caacaagccg 23580 gagtgattca tgtctagtga tttggatgaa ttcatacttc ggtatgaggc cgatactgcc 23640 agagccgagc gcaatctgga gcgcctccag aaccagatca ggcgcgtgaa cagcgcatcg 23700 acgagtggcc ttcaggattt gcgccacttc gcagacggcg cggccactga actcggccga 23760 gtcgttccgc agatcgattc tgtgacgagc gcgattcgcg ggatgaacgc gcaactggcg 23820 ataggcgcca ctggcgtggc cctggtcgcg gccggcgtca aggcgttcat gaacaccagg 23880 gaccagtaca accagcaacg catccaggcg atggatatcg gcatcgcccc ggcgcgactg 23940 gaagagtacc agcggaagtt tgctcgccag tctggaggca cgatcagccg cgagcagggc 24000 gcggaaatga caaaaaatct ggccgacact ttccggcgag cttatcgcga tatcggacgg 24060 gtcggcccgg aagcgcgaat tctgcgtatg gccggcgttg atgtcgggag cttccaaaag 24120 ggcatgcggc cgctcaacga catcattact gatctggcca cgaaaatggc caagctgaag 24180 ccggacgaaa tttctgccta cgctgatgcc cttggcgtct cgcgagacta cctgagcacc 24240 ctggctaaga tcggcccagc catgggaaaa gtcaccgaga tgacgactgc ggaactccag 24300 tccagggtcc agggcgagtc caacattcag aaattcaacg atgctctggc gaatctcaac 24360 cagacgttca ccaccctgga aaaccgagtc ggcgaaaagc tcgcgcctgc gttcaccaag 24420 ctgatcgaaa tcatcgacaa gatagtccag gctattccca atgaagtgga agaattcgcc 24480 aaggacacca aagcccgctg ggatgacggc atcaccggaa aggctacggt tggtggtgat 24540 atcctttccc ttctcagccc tggcgccctg ctaggccgcc tggcctcctg gggaactcgg 24600 cgtgggatgg aagaggcagg cctgatcgac aagtcgaagg ttcccggcgc tcaaaccagc 24660 24720 gagaagctgg ctgaccagac cacgaagtct accaatgatt ttgcggtggc gatcaacatg 24780 ttcagtggcg cggtatcgtc gttcgcgaat gccgttgacg agcgccaagc ttgggcagcc 24840 tgggcgggg aaattggtcg ggcggtcggt atgggaagca ccgcgccgac ttcgcgggcc 24900 accggcgtct atccgcacgc gatctatgat cagtcgaaga gtggcgcggc cggacaggtc 24960 ttcggcgagc caatcggcgc ccagtctctt cgcaatcgca tgttctcgcc gcagcgcaag 25020 gccgaaccgg tcaccgttcc atcgtacatc aacgatatca tcaaagatgc ttcgaagatg 25080 tacaacattc ctgagctgga catcaagaaa ctcatataca ccgaaagccg attcaacgcc 25140 agggccacca gcgaagccgg agctaaaggc ctcatgcagc tgatgccgga aatcgccaag 25200 gcgtatggta tcactgacgt atatgaccct cgccagaaca tcctcggcgg aacgcgccta 25260 ctgcgggaaa acctagatcg agcaaatggc gacatgcggt tggccttgac ctactatcat 25320 ggcggactcg atccgaagaa ctggggccca aggactcgcg catatccggg tttggtaatg 25380 agcgctccaa tcgagctgat ggaagaggct cagcgcaagc agaaggctgc ggccatgacc 25440 gtcgccaacg agacgttcgc cccggaaggc ggcgacatgg acattcgtcc ctatgatggc 25500 gggcgactgg aaaccccaga ccagggcaag aaagaagtg agcgccgcga agccgctcga 25560 tatgacgaca gggttgtgcg accggaaatt cgcatcatcg accgcatgcc agaccgcagc 25620 gacggcgaaa tcctcaagat gtctagacgt caagaggccg accgggcaga ttctggattc 25680 cggaagttcc cgaatcaagt tcgcggcgag accaagcaga acatccaggc tcaactcact 25740 gcaggagcca tcgcgcaagt gatcggcgtt aaccccaacc agatcatgcg ccgcgaaatc 25800 agccgttctg acttgctgtt cggatacaac caagccatcc tgggcaagca aggagatc 25860 aaggccgccg cgaccgaagc caacaacgta ttcctgtctc cagccaagct tgccgaagcc 25920 acggccaagg tgaacgccgc atcgcgagaa atggatattc tcaggacgta cggcgagcaa 25980 cttctgaaga gcgctccaga gcgcggccag gagctgacca tcggtcggat cgacatgttg 26040 gtcaacgtca ccggcgcgaa ttctccggaa gaggctcgtg agatattcag caagcagact 26100 gcagaccagc tgactacggc aatccaggac gctcaaaacg attccgcaac taagatactc 26160 tactgatgaa aaagagaatt ctgcgagtaa cattcaacat gccttatgga cccgaagtca 26220 tccgcgaaga tctggatgtt cgggtccgga ttatgaaggc tgcgttgcgg attcagaacc 26280 gggcgacgat ggaaattttc ggcctcacca ctcagctgcg cgagtctctt ctgtcgcagt 26340 tcaccgcgtg gaagcaccgg caacgtcaag tgggcaggga agatgaattg atgatcaagg 26400 tgtcggtgga agccggctac tctgaccagg ggcgcgagca agtttccaga gtctttgtcg 26460 gcgaagttgc cattgtcgat atcatttctc cgccacctga cattggaatc cgcatccagt 26520 gctataccag gcaaatcgac aggacgaaga ccattcggaa tatgccgccc gccaacacga 26580 cgtttgtcaa gttcgtcgag tggggcgcga acgaaatggg attgaacttc atctgcgata 26640 ccagttacaa cgatcaagtt ctgaagaatc cgggccggtc tatcactgtc gcgtcggcaa 26700 tcctggcgtc gattcaggat atgtacatgc cggacgtggc cgcgttcgtc gatgatgaca 26760 tattgatcgt gaaggaccgc gataaagtca ttcgtccgga tgaggtgacc aacgtcaact 26820 cgtttgttgg aattccatct tggtctgaat ggggcgtgga attccagtgt ctgtttgagc 26880 catcgattcg tgtggctgga ggcgtagcgg tcgaatctct catgaatcca agtgttaatg 26940 gtaactatgt aataactgct ctggaatacg agttggccag tcgggatcgg ccgttctata 27000 tcaaagtcat ggggagtcca gcagcataat ggccagggaa atcaaatcat tcaacatgtt 27060 cggagttcac tatacttcgc ggcaattctc tgctgtcgat gggctcagca tgatgtcgga 27120 aattcagaac gtgccgccag aagaattgct caagggtact gatgtattgg cgcatccgga 27180 agaccatccg gaaggcatct ggcttccatt gactgctgcg aacatcaatc tttatgtcgt 27240 tgatcgagcg aaagtaatag ctcccgtaca agttcttgca cttctgtccg aagtggtaat 27300 cgactggaac tttggttttc tcaaagactg gaccggagtc aagattccat ccagatttgt cgaagatatc aaaagcgtga agacggcaca ttcaccttct gtagttgcga gcttggtcgc gaacggctca gcctctatgc gcgagttgga aggtattat tcgactcaag atgcgtttaa gatgatagac atcatgacgg cgaagagcgt gaacgaggcc ttggcgtccg aagcatcgca 27600. 27600. 27600. 27600. 27600. 27600. 27600. 27600. 27600 aaatcagagg ctttcccatg tccaatattt ctctaacatc cgcaaaagct cccgacagga cgcgactgat cgccgctctt gacgctcggt cgcggcggga tgctctagat ttcgaagtaa tgataccggc tcaggttgtt caatatgaca gggccgaga tatcgcgacg attcaacctc 27840. tcatcacctg ggttgacacg gaacacaacg ccgtccaaag gcatcagctg gttgatattc ctgtaatttc catgggggct ggcggcttcc acataagttt cccgattcag caaggtgaca taggctggat ttatgcggcc gaccgcgaca cgtctcagtt cctggagtcg ttgtcaatgt cgaagccgaa caccggccgc atccataagt tcgagcatgg cctgttcatc ccggacgtat 28020 tccgtcgata caccatcaat tccgaagatt cggccgctat ggtcatacaa tcgacttccg 28080 gagcgaccag aatttcgatt cgcggcgaca acatcaagat cactgcgccg tcgaatgtca 28140 ccgtggatac tccgcaggcg aatttcactg gtgatgtgac tatcgctaac actctggttg 28200 taaacggtat caacgtgaac aaccacggcc acctcgaaaa caacccgcct gatgcccgga 28260 cgaagggcgg catgattgct tagggaagaat ttcatggcaa gttttgattt ttctgattta 28320 acagcgggg ggtgtaatgg ctaactacaa ctacatcgtc gatactggtg tgatagtcgc 28380 agataccgcc gacgttctga gtgacgttga agccgagttc cgcgccgccc tcggtgccaa 28440 tatcaacttg gccgcgagca ctccgcaggg atcgcttgtc gcggccgagg ccatcgccccg 28500 ttccagtgtc atgcggaatg aagcgcgaat tgccaatacc ataaacccga acgtttcatt 28560 cggaacgttc ctggacgcga tctgtgcctt gatggggatc gagcgcggtt ctgacctgtc 28620 aaccttggc tatggagttc aagtcaccgg ccgcagccaa acccgcattt ccaacgggtc 28680 tagggtccag actccggccg gcgcgatctt cacagtgatg agtgatgtca cgattcctgc 28740 tggtggtgtc gcgaccatcg atatcaaatc gcaggagtat ggcaacattc ctctgccggt 28800 cgggaatctc atcatcatcg acggaacaat tggctggtcc ggagcgaaag tcatcgcctc 28860 cactcgcgtc gatccgggca gccgccaaat gagcgatgca gagttgaaga atgcccgcgt 28920 taatcgattg gccatccaag gccgcaactc gactatggcc atcaaggcgt atgtgagcgc 28980 cgttccaaac gtcacgtcgg tgaacgtaat cgagaacaac accggcgccg ttcaagtggt 29040 gaatggagtc tcgtttaccc ttccgtatgc tgtttgggtc tgcgtcgccg gaaacccgga 29100 taaacaagca gtcgccgatg cgttgtgggc cgcccataac ggcggaactc catgggacta 29160 tggtgcgacg aacaacggcg tcccggtgga cggtccgaat ggcgttcctg tgcgcgatcc 29220 ggcgtccggt cgaaagtatg tcgtgaagtg gaccactcca attatgtacg atggatatgt 29280 taacgtaaca gtccagcaag gttcctcctc tgtagctccg gaagccattc agaacgcagt 29340 ggtcaattac gcccagggga aagtggaagg ggaagagggg ctggtggtgg gcgcgagcct 29400 gtcggcattc gaagtcgccg gcgccatcgc tcgcgaaatt cccggcatct acatcaaact 29460 ctgccaggtc gcgtgcgtcg cggctggctc gccggctccg gctccgggcg atttcacttc 29520 ggaatacgtc atgagcgcat tcggccaggc taccatttcc gttggtaacg ttcgggtgac 29580 tttcgtatga ctctgcctgc gtacaattcg gacatccaac aagctctgaa atggctccat 29640 aaccaggcgc ctggaatcac cggcctgatc cagagaaagg cgcaatggta tgacagattc 29700 agccgccaat tctgggccaa ctgggagcgc gacgttttcc acttgaaaac tgccaacccg 29760 ttcggcctca tggtgtggtg catcatcctc ggcacgccgt cgaaaggatt cggcctatat 29820 ccaaaaaaca gttcttgggc attcggtcgg ctacgccaga acttcatcta tagcggtaca 29880 caagttccgc caccggcaga cgcatcgccg ggcggcaact tctacggtgg cggcaatgcc 29940 gaaattctca acttggacga aatcaggaaa gtgcttcagc taagatatgt agcgctgatt 30000 tcgaacggct cgattgcata tatcaatcgc atgcttcgct acatattcaa tgatgatgag 30060 ccgtgggacg aggcgaccgg tctgtacttc tatctcatgg actcaaccgg cgaggatggc 30120 cctgtggaga acttggccat atatcggaaa gattgggaag gtatggtgct gttgtacagt 30180 tcgcccagaa cgaaccatgt gctgacatcg acccctgcca gcgacgccga ttggccggga 30240 gtcgatccgg ccgcgagcgg ccgtccggta acggtcgaaa cggcgtccgc tacggccccg 30300 gacggctccg ctacggtgtg caagcttact aagccggccg ggagtaccgc ttacgtctcc 30360 gcgccgatag atgggccgct ggggtccggt agcactgtaa cgttctcgtt cttcgcgaaa 30420 gccggctcca cccgtttcat tgcaattcag tcggctgccg atttccccag tcgagccgat 30480 gccgttttcg acctggattc cgggcacgtg atcagcgatc agatgttgga cagcagcgtg 30540 gtaagcgccc gaatgattcg tctggagaat ggctggtggc gttgcgttct cacgaccaag 30600 accgtcagct cttcgttccg cgctgcttac gtcgcgccgg cagaaaccaa cttcagctgg 30660 attgattcta attcaagtat ggcgattgac gtgcttatct ggggcgctca gatcgaactg 30720 ggtgatactc caaccggata cttggagact accggggcgc ccgtaaccat caccgattat 30780 gtcttgcaga atgcccagac cggaacggtc gagttcaccc agccccttcc gattggagta 30840 gaagcgtatt ggactggcga ctggaaaggc gggtctgcga ccgagccggc cagattcgcg 30900 gtaggggatg ggactcaaga tacattcaat ctgtccagtc ctgcatacat aggcctaccc 30960 actagtgggg cattcaagtt agaatacaga gttggtccgg cgcttaattt gtcgccgcaa 31020 ttgatcaacc tcatgaatga ccgggcggtc ggtatcatgc cgacttgcgc cggttgcgat 31080 gtaaaagtca ttcaggagta atgacgtgat cacacccgaa ctgataccca gtccgtttgc 31140 tgcgcagggc gacaaagacc cgatcccgca gacctcttcc actggctttg ccaaccttcg 31200 cgatggctac acgccggact acgaaatcag tctggagtcg aacaacccgc aggccaaagc 31260 ggtcgagcgg aaaattcaaa accaactctt cttcatcgcg acccagaacg cacaggcgtg 31320 gcagcggcaa atggcgccgc cgtggtttca gggcatgccg ggcggctacg aacagaatgc 31380 agaagtcgtg cgcgtcggaa atgacggcat aatgcgtcgc tatcgttcca tggtgaatgc 31440 caatgcgagc gaccctctta gcagcacgac ttgggaagaa caacccgcct ggtcggtgat 31500 gcgctccagc atcccgatgc cggctggagg cccaggccta tcttctggcg gagaagtcat 31560 cacgactggc cgcaacttca acgatttgtt gaatgggacg tgggagttct tctctgattc 31620 agtggttatc gcttctcaga atgcccccgt atatccggcg tccgctggtg ccgctgctgg 31680 catgttggag gcgaaatctt ggatatccgg gtccaatacg ttctgcgttc aacgctacac 31740 tgaccgcgtc gggaacgtcg ctgtgcgcgg gcttaatgcc ggggcatgga ccaactggat 31800 gtatgctgta aacgtcatgg ccctccaaca aggtcgagtg acctatggag tcgcggccgg 31860 cccggcgaac gcttacacgt tgacgctcgt tccgcagctc caaggcggcc tggtggacgg 31920 catgatcctt cgggtcaagt tcaacaccgt gaacaccggc gcctctacca tcaacgtctc 31980 cggactcggc gccaaagcca tcgtcggcgc ggccaacttc cctctcactg gcggcgaact 32040 tggccaagga ctcatcgctg agcttgtctt cgacgcagca ggcgaccgct ggaggattct 32100 ggcaggcgcg ccgcgcatcc aagtgggcaa cgcagatcag gactaccagg cccccagctg 32160 gaaacaggtg aaggactatg tagcgtccca aaagctcacc gaagtggatt gggccgatgt 32220 cgtcaacaag ccgaacgtcg ccatccaaga caccacgccg tggttcgcca atctggagct 32280 gtctgacgct cggcctttca tcgattttca tttcaacaac aaccgcgcca aagacttcga 32340 ctatcgcttt atctctgagg ctgatgggtc gatggcattc tattctcgcc aggggtctgc 32400 cggtcctacc caggacatcc tgttcagcag gtcgaatgta acattcctcc agccgcgact 32460 ggatgttgcg aaaaacctcg catacatcgc gaactctggt cctctttggc agaacaccac 32520 tgccgatcag cctggttgga aattcacctt cgcacaaggc gtggacgcca acaacaacgc 32580 ggtgatagca gtcaatacca ccaatcctga cggctcttat cgctcgcaaa tcatgcgatg 32640 ggactgggcg tccacgaacg tcatattcaa caatcgccct ctgtttgctg gacaatacgt 32700 tccttgggac tccggaaact ttgatccagc caccaagctc actgtcggga ctaccaacaa 32760 catttcggga ccgaccggaa ttcgcaatac caccagcaat accggaaata tgaacacctg 32820 gggctccagc tccacaactg catcgtatgg aaacgcagct cttcaaatct tcggcagagg 32880 gggtggcgag cctgcggcca tctacttcga caactcccaa accggctggt atttgggtat 32940 ggacaaggac ggccagctga agcgagcagg ctggtcgctc ggcaataact cctatgtggt 33000 caccgacgag tcgaatattc gtttccacgt gaattccatg gctggcactc cggtatgggg 33060 cggaaatgaa ttctgggggc cgtggaactt caacccgaac accaagctga ccattaaagc 33120 cggcacgcag gaaactagca gcactgcgat attcagcgga acgatgccgt tcgccccaat 33180 cgcgtctctg tcagactatt cccaggcgcc gttgacggtt tacaactcgc cgactggtcc 33240 atctgctaag cctgccgtca tcgcgttcat tcgccctggc aactggggag cgttcttcgg 33300 catcgatacc gacaacaagc tgaaatgggg cggcggatcg ctcggcaaca gctccaggga 33360 gatcgccgat tccagcaaca tcatgaatct ttgggcggcc aacccgaccg cgccgtcctg 33420 gaacggccaa accgtttggc gatccgggaa ctttgatccg gcaacgaagg tggatttgaa 33480 cgccgcgaac gccaccaacg gcaacatgat cttcaaccgc atcgccggaa ctggcagcgg 33540 gatcgcctct tcaggccgcg tcggcgcaat cagcctccag aacggcgcaa cggcaggcgc 33600 ggccgcagcc gtaacattcg agcggggcgg tggtttcttc gtcaacttcg gtttggacac 33660 cgacaacgtt ctcaaagtgg gcggcggaaa cctgggggcg aacgcctatc ccatcatcca 33720 ctccggcaac tacaacaact acatcaacca ggcgctggtt caggtgggtc ttggcggagt 33780 cggttcctat ggcatctttg cggttctgga cattgccgct ccaaccgcga ccgttcaacc 33840 gggagtggtt gtggacggtt ccattctcat ctactcgtct tgcgccgcaa actacaatag 33900 cggtcaaagg cctgccggaa cttggcgctg catgggatat gtagtcaacc gggatgccaa 33960 cactcctgac tccgcgaccc ttttccagcg agtgacgtaa aatgaaatgg acgcggatca 34020 gaaaccctcg ttggctggat gaaacaaaca tccacgccat ggtgactttc gaggggatcg 34080 gggaagttcc tttcaccgcc aatccgcacg acgtggaggc ccacggaagg gccatccacg 34140 ctgcgatcct atccggggcg cacggaccta tcgccccggt cgatgcgaag cgggagcagg 34200 ccttgcaggg cgctatacgg gccagggaaa agcgggctat ccttcgtgat acccgctggc 34260 ccatagatcg tcacgacgag cagaggcggc tgggtatcga acccacggat ggacctgggc 34320 tgatcgcagc ccttgtttac tggaggcagc agattcgcga ttggaatagc ggggatcggc 34380 cgcgacttcc catggctttg aaaacaatgt tcaaaaatca ggagtactga tgaaaataac 34440 gaaggatatt ttgatcacag gaaccggatg caccacggat cgggcgatca agtggctgga 34500 tgacgtccag gcggccatgg acaagttcca catcgagtca ccgcgagcca tcgcggccta 34560 cctcgccaac atcggcgtcg agtccggcgg actggtaagt ctggtggaga atctcaacta 34620 cagcgctcaa ggattggcca acacctggcc tcgccggtac gcagtagacc cgcgagtccg 34680 cccgtatgtc ccgaacgctc tggcgaaccg cctggcccgt aacccggtcg ccatcgccaa 34740 caacgtgtac gcggatcgca tgggtaatgg atgcgagcag gatggcgatg gttggaagta 34800 tcgcgggcgc ggcttgatcc agctgaccgg gaagtcgaac tattccctgt tcgccgaaga 34860 ctccggcatg gacgttctgg agaaaccgga gcttctggaa actccggccg gcgcgtcgat 34920 gtcttctgcc tggttcttct ggcgcaatcg ctgtatcccc atggcggagt ccaacaactt 34980 ctccctggtc gtgaaaacca tcaacggcgc cgcgcctaac gatgcgaacc acggccagct 35040 ccggatcaac cgctatatga agaccatcgc cgcgatcaat caaggctcct gacattccac 35100 ccaaagaaaa ggccgcttat tcagcggcct ttttgctttc tggctttgcc tcttcagcca 35160 tcttgacctc gaccggcgcg gcggactcct cctgagttac cgaatccaca tagttcccta 35220 gtgaactcag aacgccgatt aacagcgctc ttactacctt gtccttgact gtctcgccta 35280 tgatcttggt cagaacggat atcaactctt cccggagtct tgggctgatt cttggccgaa 35340 agcgcttgcg atgctctttg cgtttcatgt ttagtcctct gtctgcggtc ttctcctcac 35400 cccgataatg gcttggggat gcgctgtgtt agtcggaagg gtcgggcgct attataaccc 35460 gtcgaaaatg ctcgcgctta actgtttaac gatacgcacc gcgatactaa atcgccttct 35520 ttctggccaa ggaactctgg cggcctggtc cggtctaagg cctaatttgt cgacattaaa 35580 acgagaaaac ccggatcgcc tgtaggacaa ggcgtccggg tttatttcga tctagtgtac 35640 gctagaatca gtggcttccg ccccaaccgt ccagccagca atcgaagacg gcgtgtctcg 35700 gcttgtcctt ggcgccatgg gagaagtgct tgaaccggat gacctggccc ttgagatact 35760 ccctgtcatt ccagcggcgc tgtttctcgt cgtgggtcag gctggaggcc gacacgttga 35820 aggtgactcc aggccacaga cgttcgttgc ggcagacgaa cgcaccgacc attccggacg 35880 gcgacaggtt ttctgcgtgg ctggagcggg ccgtgtggcc aagttcattg atgaaagctt 35940 cattgttgtt gtgcatcaac tcttccacgt cgatgatctc agcttcatcg tagtcgtatc 36000 gcttgacttt cacacagtgc ccttccttgg cagtcgagcg accgaacttg tacagtccat 36060 cagcgcgctt gcccatggac ccttcgaatc ccagcatcgt gtggcggcgc tcgacttcgc 36120 tgaactgttc gatggaagtc accagttcct gctcgaccag gtgaatcctc tcatagccga 36180 ggcagttacg caggaagttc acgcgctcgg tcgccctggc taggcgctct tcggtcggtg 36240 cacgatgatc ggtgaaatca tcgaacacat ggaaagacca gtccggctca ccgctgtggc 36300 ggcgaagatc gccggacgac ttctggaaaa ctttcgggtc gctgatgtcg ccgcagacca 36360 gctcgccgtc caggccgttg aacagtttat cgctgaggta ttcgtagatc gattgattgt 36420 tctgccgctt gagttgacga gtcagcgcct cgccttcgaa tacgaagcag cgaaatccat 36480 cgatcttcgg cgagaaatac atcggcagtt ggccttccag cagcttcggg tcaaaattcg 36540 atgcgagcat gggtttcata cagttctcca gaaaagaagc ccggcgaacc gggctaaatg 36600 gcggtaagcc ggctcagatg gtttcgttgg cgtggttcag ttcggccatg atcgacgcat 36660 agagctcatc cgactccttg atgaacacgc cgtcgtacat gacgcctttg cgatccttga 36720 tggtgtcgta ggcagcagcg tagcaggcga gcatggtggt gtcatgctct tccgtcacgt 36780 cgaacagagt catggcggcc gataccaggc tcttgatggc caacccatga tttccacgtg 36840 ccagagcgcc tgccagatcg ccgaggcgct gcaaatcgtc gccgtaggtg ggatgtactt 36900 cgccgctctc gatgaaggcc gacagatgat cgaacagatt ttcgccgagt tgcgcggcca 36960 tgatcgtggc aaccaccatt acgtcgccga tgccatcttt cacatcgacc gggttgttct 37020 gaacccaggc ttcgcatact tctgcgaact cttcgaccaa cttcaggaat tgatctttcg 37080 cagacgagcc tttgatcagg ttacggtcgg aagcccattt aaccaccagg tcgtgaagtt 37140 cgcggctcat gatttgttcg atgttcattc tttcgattcc ttctgtattt gggatttgac 37200 tgcgttgatg atggacgccg tgctctggcg cgatccgtcc ttggttgtgc caaaatagaa 37260 ggccataaca gacttcagtt cggcgaacca atagccgatg atggtgccga tggcgacaga 37320 ggaagtcggg tccatcagcg cctcgcggcc gaaggtgaag attgcgatga tgatgagaat 37380 ggagcctgtc agaagagcga atgtaatcgc cgggcgaacg aaatcgttct gctgcgcggc 37440 aagcctcctc gccgaatccc tgtctgccgc ctctgcggcg aactggctaa gctcggcctg 37500 gagctgattc tgctcagact gaaggcgatt ttgttcggct tgaatcgcaa gctcctggag 37560 acgaacgcgc tcggcgctct ggagttcggc gaggcgcgct agagcttccg gattcgcgtc 37620 tagagcgctc gcgactgagg ctgggtcggc cttcgacccc agcgccgtcg cgacgatagc 37680 gccaacggcg gcgcctgcag gcccacccag gagcgacccc agagccgggg cagccgcgcc 37740 gatcttacta cctatgtctt tccagtccat ttcgactcct caaaagaaag gcgccattac 37800 agcgcctttc tccggccggt gatttagaac tcttcggctt cggtcgcatc gccgacgcca 37860 ccggcgtcac tgcgaggctg ttcctgcttg ctgtagtcca ccttcacctc gccgccgacg 37920 aacgacttgt acaggtcggc cgcagccttg aagtgatccg ggttcttcac caggccttcc 37980 agctcgaact ggacgccgga ccagctaccc ttgtcgttcg acatgcctac ggtggtcata 38040 cggaccaggt tggcgaaagt cggcggggtg cgcaggccct gcggggtctg aacctttttc 38100 tgggacagcg cggtcatgag cttcttcgag gccttgatct gcgaagacga cagggagatc 38160 agagcctggc cgaaatcgcc ggtgtccgga tcgatgacga tgacgtaatg accacgggtg 38220 tcggcgaagt agtcagactt cttgtcgctg accgaaccgt cttcgttcgg cgcgtacagg 38280 cgtccttcga cttccttcac cttggtcggg tctttcatca tttccttgaa gtcttcgacg 38340 ctgatggcgc ccttgaaacc gccctcggcc tcgcgaccgg cccagcggat gaactcgcgg 38400 cggtacgcgg ccggaatgat cagcaggccg gtcttgccgt cgtaaacctt gccggtgacg 38460 gtattcagga acatgccggc cttcgcgccc tcgatgtact tcggatcgtc ttcatcgacc 38520 tgcggagaca tcttctgcag aacctggatg aaggggatgg cataggactc ggcatcggcg 38580 ccttcgaagc ctgcgccgtc atacgatccc aaatccatga agtcgggaac ttcggtagtt 38640 gcgacggcgc cgccaccggt ggcaacttct acggccttgg tttcttcggt tgcttcggaa 38700 gtttcggttt tcttaccagc catgttaggc tccttgtttg tcgaatttca gttatcgcta 38760 actgtgggtt tataataacg gaagttgcaa ctaagtaaag caaattacat atcaagattt 38820 gctctttttc accttcggtt tcgtgatctt ggcctctttg tattcgtgta cgccgatgaa 38880 atctggcagc tcttcgccct tctccaggta ctcgcgaccg aacgcctgga gggtctggta 38940 atggacatcg cggttgatgg tggcgtcata gccggcttcg atgatggcct cggccgcctt 39000 cttcgcatct tccatttcgc cgcgaccgaa ttcggccaga accttggtct tgatgatgcc 39060 gtcgttgtcg gtttcttcca gccacttcca gaacttcgat ttgttctctt ctttgacgga 39120 aatgatggcc ttcggctcga ctttgaccgt gcgaccgtca gccagagtag tggtcttttg 39180 accaagctcc tccagcagct ccggaatggt gttgcgcttg agggttttca gctcctcttc 39240 cttttcggcc agcgcctttt gaagatcgag gatttcgacg tccagctgcg aagccttgtc 39300 caccaggttc agcagtcgat ggccgatgtc ggtggcttca accgccattt catccatgac 39360 gccaaaatag tcgatttcgc ccggcgcgtt ctctttcaag tattccggga tttcaagctc 39420 ttgctctttc atgtccgcct ccaacttagt gatgttccct tacttgaacc aagtattgag 39480 tagatattat gccgcatctt ccttgatacg gctactgatt tacatattaa atttcgtcgc 39540 gagtgctaac gtcagcctca aacacgccat caacgacata acttgccagg ttgcgtttcc 39600 actccaagct gacctggatt ttctcgtcga tggaatccag acagatcagg tcgaagtaca 39660 gaaccgagtt gacggtgccg attcgatgat ttcggtcttc ggactgcatc cgcagctcgt 39720 tgtcttcgtc ggtcgtgtag tagatggcca cgtctgcggc tgtgagcgtg atcccgatcc 39780 ctgctgcggc cgggttgccc aggaacacct ggacgcgctt ggcctggaaa tcgtcgatca 39840 atttttcccg ctcggcctct ttggtctcgc cgtagtaggt gccaaacgaa atcccttggg 39900 cctccaaata cgccttgatc tggtcgattt cctgaatgcg catggcccag acgatgatgg 39960 aacgctccgg gtcttcctcc agcagaccct ccagaagatc agtaaacacg gcgaatcgcg 40020 ggttgtcttc gggcggcagg atcaccggct caccatagac gttgatatag ccggacgcca 40080 cttgcttgag tttcgagcgc gctgccgcgg catcgaaaga tacatcaagc atgaaatctt 40140 cgttctggag aacaaagtgg tagtcttctt ccacgcgctg gtaaaccttt cgttgctcag 40200 gcgacatttc gaagtatatg cgcttgtaca ctttgtccgg caggaatggg agtgcttctt 40260 tcttcgttac acggaaactg tgcggctcga tcagggaccg cagcttgtcc aggttccgga 40320 ataccgggcg cccacactcg tctttttcga ccagttgcgg cggcatggtt tgcttccctt 40380 ccagcttgcg catgatagcg atcattcgag gatcgtcact gggcaccaag acggaaaatt 40440 cggccacaaa cgcccgatag gatttagtcc ccagaattcc attccgcaag aattggaact 40500 gcatgaacaa atcggtcggt gcccgcgtca gaggagttcc ggaaaggatg cgacgggcca 40560 cggccttctc gcccagcttt acgatctttt tcgcacgctt ggcttgtggg tttttgatcc 40620 tcgttgactc gtccacaatt gcgcaaactt tgaatgtatc aaaggaatcgc tcgacctcat 40680 catagccagc ctggtggttg attgcatcaa cgttgatggc gaagacgga agaacttttt 40740 catctgcgaa cgtctcggaa tacagacggt ccaagcgcgc cctggccttt ttggaagtcg 40800 gtcggccgcg ccaatccacg ctcaaagtct tgatcgcgac gtgggtggga atctcgcgca 40860 gaatccagtt ggtgtggacg cctttgggg cgacgatgag cagcgcgtcc acgcgcccct 40920 gtaggaagag gcgaacggca tcagccaaag tcgtccaagt cttcccggtg ccctgctcca 40980 tcaggtatgc gaagttccgt ttgttcaggg acgctgccag ggcattgaat tggtgctgca 41040 tggcctcggt cttcatgccc ttgacgggat atgttttggc tttcatttgt tctccaaatc 41100 ggcgaggaac tgaacaatgt tatccagtcc ttctgcatag ctcgcaactt ccaccaagtc 41160 gcggctgtta agctcgaaca aatcgaacat aggattcagc agcagccaat cggttccgat 41220 cttggccagg acgaagcccc ggccacccca gccgatccgc tcccgaagaa aagggatttg 41280 cccaggttcg aaacatctgg ccattgggca ggtggaagcg cgtttcggcc actcctccaa 41340 agccttgaac tcgacccaga actggacacc tcgacgattc aggcagatcg aatcggacat 41400 gccagaccgc cgcgtctcca gaaagtcgat caggattcgg ccgagcgagc gctgcttaaa 41460 cgcattcgcc gctttcgttt cgcgatcatt catcaccttc gccctctttg gaaactttct 41520 ctgcttgcgc tgccaacttt gacttctcgc gctcggtcaa tatccgcttg acggccttca 41580 cgatgaacat gtcgatgccg ctgagcctcc atcctttgat caggaaccaa gcgccggtcg 41640 gcgtcccttc agcaatctgc tttccgtatt gcagatattt ttcaggccga attctgaaac 41700 gtatcggctg atcaaccgag tcatcaacgc acatgatgtc gagaaactgc gactggccct 41760 tgtacaccgg gtttttccct tgatcagccc tcttcttctg gcgaatcggt tcgttctcat 41820 cagacagaac ttttttcacc atcttgacaa tgaccagacc atcatctcca tcgcggatat 41880 cccgaatgtt ctgaatgggg tttccggaag ttactccaac cagctccgga ttgtcataag 41940 catgacccca gagcgtgtga gcttcgttca aatctgcgaa ttgaacttca gaattcgaca 42000 gactcgcggc gactttctcc caatcctgaa gcgtcttcag gtgggtgcct gccagctctt 42060 tatattgagc cttcagctcc ttaagatcgg ccttcaactc cttcagatcg gccttcaaca 42120 gtttctccag ttctttgtct tggctgattt tcgccgaaag aatctgggct tccagagctg 42180 ctacatcagc agccttgtcc tcaacatcct gtgccgatat cgggcaattg gccagggcga 42240 tcctcgcggc cttgacttcc tcgcgaagac gcaggaaccg ctcggccttg gccgggccga 42300 agcctttggc gttcatgatg ccgccgatca agcgtccatc cgccactacc cagttaagtt 42360 cggaatgctc cgggtccagg gccgtatatt ctacgcttc cttggccaat tcgcgaagta 42420 tggacacagt ttgctggtcg tctttcgccg cccgaagaca cgcggccgcg tattccaggc 42480 gatgatatcg cttcatgtag caggtccagt acgtcaccac agcgtagctg accgagtggg 42540 agcggttgaa tccccaggcg ccgaacgtta ccatttcctg ccaaacacgg tgagcatcgt 42600 ccggggcgac gcctatggtc ttggcgccct cgatgaacaa ttcccggcgc ttgttgaaaa 42660 attcttcgcc ctttcgcgca gacatggctt tccgaatcgc cgacgtttgt tcccagtcga 42720 actgcccaat gtccttcaca atggacatga tctgttcttg gtacaggaaa actccatatg 42780 ttccagacag atactgctcg acctgcggga tggtataggt cacaggctcg cgaccggcca 42840 cgcgctcgat gtatttggtg gccatgcccg aagacaacgg gcctggacgg gcgagcgccg 42900 ttatgtggtc gatgttttcg aacgcggtga tattgatcgc attggcgacc gagcggacgg 42960 cctggccttc gaactggaag atgccggaca tcttgtcttc gttgagaatg tccagaaccg 43020 ccttgtcgtt caacggcaag tcgtacagct cttgcgccgt cacgcaatta gcatcttgga 43080 tgacgcccag agttcgaagc ccgagcgcat cgatcttgag aagattcaga tattctgaat 43140 cgggcttgtc gagctgcgcg acaccttcag aagttaccgt gcagaagtcg atgacttcat 43200 cgttgcagac caggatgcct gccgcgtgga ctccagagtg ggatgggtga atttcgaggt 43260 cgcccatgca ggcggacgca atctcatact tttcacggaa gtcgcggccg ggttgagttt 43320 tttcgaaagt gtcctccaat ccttttccat atcgttcgtc cgccgatgta tattcgatga 43380 tcgagttttt gatgttgtcg gtatcgtgga aggggatgcc gaagcgtttt ccgacgtgag 43440 cgataaccga cgcggccttg agtgtgttga tgttacccaa cttcacaacg ttccaagtgc 43500 catacttctg ctggagatat tcgaacacta gatagcgatg ggtatcggcg aagtcgatat 43560 ctatatcggg aagatcggac cgggaaatgt cgataaagcg ctggaagaga aggcgatgag 43620 ggagcgggtc aacctcggta atgccaagga gatagcagac caaagagccg gccgaagagc 43680 cgcgagctgg accgaccagc atgtgcttct tggcaaacgc gaccagatct gccacgacca 43740 ggaagtagct gtcgaaatct ttcagctgaa tctgcttgat ctcttcttgg aatcgatcct 43800 catactcctg ggtccattcc ttgatgtggc cgcgactgag gcggtaggct tgcccctcgc 43860 gagccagagc gacgatatca ccatccaagt ggatcatcgg cgccttcgcc agtttcacat 43920 ccgccaaccg ctcgactacc gcacgagtat tggctgcggc agtatcgaac tcttcgcgag 43980 tcatgatgtg gcgtaaacgg ctccacagct cctcttcggt ggcgatgtgg cgaaggccga 44040 ccgattcccg caccttccag gccgacgcga aatcagcatg gtcgatggac ggcatgtcgt 44100 tgtaagaggt aattaccacc ggctttccga atgccctggc cgtctccata gcgccgtgcg 44160 cggcgaccat cgacgcggga ttgatgtcaa tgtagtcgat tccggccaga tccagatggg 44220 cataggcctc gccagcgaat ttgatgacgc cgtcagcttc ctggaattct tgcggagtca 44280 atccttgatt ctggaccgac ttggaagtca agcggtagaa cttcttggtg tccttggcga 44340 gcacccaggc tttgagcttc agctctttct cgccatcgtc ggcgcatttg atcgggattt 44400 ccatgccgaa tccgcgaggc agttctgcct tggtagcggc ttgttcccaa cggacgtggc 44460 cccatgttcc atcatcgacg atggcgacga atggggattc gatctctttg gcgcgctcga 44520 tgatctccgg gaatcgacca tatgcggcgc cgtaggagta accagagcga acgcggagct 44580 gagggaaaga catcatgcgg cctccattgc ttgatacgcc cgatacactc ccatgcgctt 44640 gcagacttcg tggagcagcc gcacgtcgtc gagcgcccgg tgtttctgta catatggtcc 44700 gcagtagtgc tcataaagat gttgcagccg catgcggtgg ccgaacaacg gcgccgactc 44760 ttccacagta cagatatcga gcgatgggaa attgacttcg tccaggccga acttgccgcg 44820 agccagatcg caggtcagca tgaacttatc gaatggcagg ttgtgggcaa tattcgcgtc 44880 ggctctggaa aagaagtcgc gaactttctg gcgctgatcg aggaaagatg ggtgcttgac 44940 caggtcttcg ttcttcaacc cggtgatctt ggtgatgatt tcctcgataa cgattccagg 45000 attgcagatg aactctactt catccaaaat cttttcgcca tcagttatca cgccggcgaa 45060 ttcgatgatt ctcggctgct ttctcagact caccctttgg tggaacggga gtcctgtggt 45120 ctcagtatcc catacagcga atatcatgtt tgttccctct tatgtcgaaa ggccggctgc 45180 ttcgcgacc ggcctgagga gtataccgcg acggctgaag atttacgcct tctgtccgtc 45240 tttcggcgtg atgcggccgg agcgcatggt ggcgtgaaca aacgccgaat agttgatcga 45300 gtccaaggcc gaatcggcat ccttgaaccc gctattcgcc aggcgagtga gtttacccac 45360 catgtgcatc acgaacaggg cgagtcgatg atcatcggcg gtcttcgcca ccaggccgtt 45420 cgggaagagg atttccatga tctttccgta catcagatca ttgcgaccat aggtgctctg 45480 gcgggcgcgg aagacttctg ctgcggcgta cagattgttg agaacatctt ccgcgaaatc 45540 atctggatgg gaatcatctt cgcccggcca gacggattcc atggcgaacg gcgcggcgtc 45600 ttcggtcggg tcttcggact gagccgtttc agcgagcgga gacggggctt tcgcaaacgc 45660 ctcgtcgagg gtaggggcgg agttcggggc ggccaggaac ggctcgcctg ccatgtcgtt 45720 gggcgcgcta tcggggtcgc tatcggccgc gacggcgaag aacggcgcat cgcaaccttc 45780 caggttcagg atgtaggagt cgatccccag gctattgtag gcatcgatga tgtcctggcg 45840 atcatcgaac gccgcgacga tcttggtgac gccttcgatt ttcttcagga tgtcgagcgc 45900 gactgcccgc ttgaactgag gcgccggctc ggtgttacca tacggccgca tgatgagttc 45960 atactcgcga tgttcggcga tgccgagttc gcggtggagc ttggccctgg tctggaaaaa 46020 gtggttgtcg gttcggccgg tgacgaagaa aatcatgagg tcggcgtcga tggcattcct 46080 gatgcgacct acagcgtgcg ggttgagagt gtccttgtcg agacgagaat gatactcgtc 46140 ccattgccgt tccaaggcga agctcttgcg gtggctatcg tcgaatacgc agccgtccag 46200 gtcgaagatg atgatgccat tctttggttt gcgttccata ttcagatttc cttactggtt 46260 gctttctggg tgacggtttt atcgatgaac gtcccatcag aagtgaggcg gaaaacttcg 46320 ccattctgga tgaaatcgaa cgattgcacg ttcatcgtga tgcgaatgga ttcgctgccg 46380 ttggtcactt cgacttgtgc gatgtcgcca actttctcga caatgatctt catgttacat 46440 ggacttccca ttgacggcca cagggttggc ctcttgtttt tccgatcccc agaaatcgcg 46500 gcgcagttct tcctgctcgg ccgagcgatc catccagggg cgatagaact tgcactggta 46560 gataggttcc aacggaacat caatcacagg aatctgacct ggctttgtct ccagagcggc 46620 46680. catgaaccgg tcataggatt tctgctggat ttcctcttca ttcatcacct tcgacccata gcgcgggaag gcgcaggagc cggtggcgac gcagtgcggc tggagcaggc tgtcgaacat 46740 aggatagact tccagaacca gccggcgcat ttcgcggaat acttcctgat attcaccctg ggtccgaacg cacaggcga ccttcgccat gtcgctgaga gtccgcagat tgaacttggc cgcgatcttc gtttccatgt tggaagggat gatggcacga gcgtcctgga gcgacgcgcc 46920 ggcctccaga agcttctggt agctggtttg cgcgtcggca atggcgtcat gccacagacg 46980 gttcagctct tcgcggacat ggtaggtcgg gtcaggctcg ccatttaccg tagccggttc 47040 gtcgaattcc cagcggaagg cttccggctg aacgacggcg ctgatttcca gagcgcgact ggtttcctgc tgataagccc cggtacgagt ccgaacgagt tgatgggtga agttcttgct 47160. 47220. gacaccctcg atctggaaaa tgaagtccac gaactcgaac ggcgagcgga tggtgtccag catgtacttc cagtggtcaa gcttttcggc ctcggtcatg gtcgccgggt cttggccgcg 47280 catgcgagtg gatttcgtcc ccaggagag ttcccaggcg ttctgggtgt aactgatcag 47340 agaaatttc atcagaaatc ttccggaatt ggcgtgaagt ggaatttttt ggttagagcc agggccaggc cttggggcttg ctctttacga aggccatact gctctatctc ttccttgagc 47460 agttcgcagg cctccagacg cgactcatac tcttcagcct cctgaacgga tgagaaaacg gttccaccag aggttcggta cacaagttca atcgacatga tgacctcagt agcagcggat gattcggcg cggatatctc gacggtcgag gtagtgctca cgaatcttat cgcggggcgcg 47640. ctcggcctct tctcgactgc cgaacgacag gttgaacgaa gtgaaaggct tatcgtccag ttcagcgccg gtttgataca ggatgcctac cagaacgaaa gacggcgcgg tcttcggctg ctggtcggct tgcatttcga gttcgagga ggacatagga acctcttcag gatgatctgg tgcgtaatt aatagcgctc ctgctgagca gctacggttt ccggctcgta gatgagcatg tcaacgattt ccgggcactg gcctttcacc cagtcgatgg ccgcgaccag tgtggtggaa 47940. gcggagaaag agaaagtgcg gtaagactca tggatgtacg gcgaccccat cgaatcgcgc tcggtcgtgc gagaaatgac tgctttgata ttaacgatcc ggcccatctt cggcctccac 48060 tttagcgatt atatctgaca ggctcagctt ctcgccattc aggaaataac tggcgcgaaa 48120 cttcctgtca ccctctggcc cgacgatccg ggccgttatg gtgagactcc cgccgccaag 48180 ggcatcggtg tccctgaaga aagccagcag cgcccgcttg agcgctgcct cgcgaggatc 48240 gacggccatt aacctaccac gttccagccg tgctgagcgc accaaaccgc accggcccct 48300 gcaggaaggc tattcagaag gaacacagga gtcaggcggc cgtcctcggt catatggatg 48360 aagtagcggg cgccttcacc gagccactcg gccttggcga tagcgcgttc gagattggcc 48420 ttggtggcgt aggttttggt gtggttcttg tcggtggaga aggttacttc gcgggccatt 48480 tgtcgattcc ttttggttga agggtttcgc gtttcgatga gggaatatta cgcccacctg 48540 atccagaagt aaagcacttt tgtaaattac ttcacgaaca tccgcttggc cttctgataa 48600 gacgaagaag tcatcaggcg ctcgatgacg tccatgtccg aaaccagatc gtccagaagg 48660 acgttgcgcc aggtagcgaa ccggccgagc gagaagatgc cggcttcatg ggtgagattc 48720 cagatcatgg attcgcgctc gtcgcggccg agcggaacga ttttgccttt ggtctggatg 48780 gtcggctcgc cgtcctcgat tagctgtttc cttctgatcc cgaaggccgc gcagacttca 48840 tccaggtccc atgccggatt ccattcgatg gtttcgatct caccatcagc gttctccaaa 48900 acgccattcg cgacggattc cacgatcaga gtatcgccgg tgatggacgc gcgaaatgtc 48960 ccgaagtcgg gactggggaa ataaacggtc tggaagacgt cacaagggat ggaaagcttg 49020 tatcgactca cgatgatgga tgttcctttg ccgaatgacg ggtcgatacc caggtccatc 49080 cccgcagcag ccaggttggc gcggaacggc gcggtgctta tgacattcac atggtcatct 49140 tgccggcgaa ggtactggaa gaaagaggcg tcgaaaggac ggctccaagt gatacgattc 49200 gcaagcttag ccaccagctt ctcatagtag tcagccggtg cgatccaacg cttttcagtc 49260 gccagattcc agatggaccg gtccgacagg ccgcccgtta ctttcctgga gtacatgttg 49320 cagtggtcga tgcgcggctg ggaaatgaac tcgccgtcga tgtagatagc tttgtgtaca 49380 gtgacttcgc ggacgggat accggtgagt tggccaatta ctggcgagcg gaatcgcaag agggcgttgt gacgctcctt gttctccggc gtcgccgcgt cgatgatttg ggcttgagga 49500 aagcgatgcg cggcgatcag tccggcgagt ccagcaccta cgatgatgac tttctgatca 49560. ggaatcatga tttgttcctt ctgaatgtac aaaacttgag aggataaaa agggacccat tttcatgagt cccttgaaga gctagacgat tcagtctcag aagagcggcg gcttactctt cttcaccatc ggaaccgtcg gcgccctgat cttcaccgtc gtgctcctgg ccttcatcac 49740 cggccttctc gtcatcgccc tggccagctt cgtcttcctt cgaagcgatg gcaaccagat 49800 cgacccagcc catgacttcc agcttgctca buyctgcg aaccgaggct ccatacagca 49920. ggtgtgccac tttctcgccg aaagcttcga tttctaccgg ctcaccgacg gcgcagttct 49980. cgttgatgta ggcaaacacc ttgccgcgaa tcgaaatggc ctgcggggtg ccatggccgt cgccggtcgg gatgaagtgg gtggcgcggg ggcgacgcga gccgttggac ttcagttctt 50040 cacgacgggc ttcggccttc gcacggcgct cttcctgctc ttccttgcgg cgctgcttct 50100 cggcttcgcg ctcggccttc ttctgctcgg ccaggcgctt gcgctcttct tcacgagcga 50160 ctttctgagc ttcctgggcg gccttcttct cttcggcctt tttggctcgc tcggcttcct 50220 tctcggcctt cttctgctcg cgctcggctt ccttggcctt cgccttctcg gcctgctcgg 50280 cttccttcgc cttggccttt tcagcacgct cggcctcctt ggcggcggcc ttttccttcg 50340 ccttctcggc gcgctctgct tccttcttct cacgctcggc cttgcgcttc tcttcgcgct 50400 cggctttctt ctgttcggct tccttggcct tggcctcggc cttctcggcg cgctcgcgct 50460 ctttacgttg acgctcggcg gccttctcgg ccttgcgcag ggcggctgct tgttccttgg 50520 tcagctcttc gccttgggtc tgttcgttct ggtccatgtt cttactccgg gaatgtttga 50580 aatgatggct tattggcctg tgagaggatt atctctaaac taattgaaga agggaatacc 50640 tttcgcctga acttctctaa atatttttct ttcgggaaag tccagactcc agggaactta 50700 tttatgttag cgaagttttt aactcttacg caaaaacaac aagtattcaa ttgcgcgagt 50760 tatcccagta tacatcaact gactataagg gatggacggc aagttttctt ccaacatggc 50820 gacccgtttc cattccgatc cctgcgactt atggaacgtc atcgcccagc cgaagtcgaa 50880 tccgccaatg gccttctgtg cctccagccg cacatcttcc tcaaccgaaa agctaagagg 50940 attgaacttc acccagcgct catagttcgt gccgataatg cgaactttgg caaacagcat 51000 ttcatccggc tcgtcatcat cttcttggcc ttcggggacc ggcttgaagt ccagcagaat 51060 tgcttgctcg ccgttcatga tgccatattc gtgctggttc ccggtgcaca ccagcttctc 51120 gccgatttcc ggttgtacac ccttgtagcc gaggatgcgg cgcgccctgg cgttcaaacg 51180 gcggcgagta ttgttgtagg cgcaaaggat cacgccatca tcgtccaaga acgtccgcat 51240 ttcgtcgtcc gacatgtcga atccggcccg taccaggatg tcgtcatact cgcggcaggg 51300 taggcgcttg ccctggcgga cgaacatcga cgcccgaacg atattgccgg cgttgcgctc 51360 gatttcggtc atgatggtgt cacagctgtt ctcatggaaa atctggacgc cgcgcacagg 51420 aggaacttgg ccaaagtcac caatctccag aaccggaatc cggtgcgaca gcaagcgctc 51480 ttcatcccac tcgccgatca tggacgactc gtcgagcacg accaacttcg gcttctcgtc 51540 gagcgagtct ttgttggcaa acatgatttc gccgtcttca tcttcaccaa tcggccgata 51600 gatgaagctg tggagggtcc gggcattggt gcagcccttc tcgcgaagcc gcgctgctgc 51660 tttcccggtt ggcgcgacga agactgtcca gtccatcgag cagcaaagtt cggcgattat 51720 cttcgcgatg gaagtcttac cagttccggc gaaaccagcg agtctataga cctggcggcg 51780 gtgcgctcga tcacaccaac cgcgatacca gtccacaacg gaattgatcg cgtcgatctg 51840 ctgactgttt ggtcgaaagc cgaatcgctc ttcgatctga tcgacggtga agttagatgc 51900 tgacatattt gcgttctcca acgctaggtt taattgaatt gaggctcagt ttaagcaagc 51960 cgtccacaga ccatccagta tcacgacgat acttgcggcc gtgcggatcg acatagaagt 52020 ttttcgtgcg gcgcagcaga acataatgcc aagcggcgcc gagcgcgtgg actcttcctt 52080 tatatgggaa ggccttcgcc tgctctgcgg cctccttggc cccagggagc cagcggacgg 52140 tcgaaaggac caggaccgcc cccttaatag cctgggaagc ggcgcggccg tcctttgggc 52200 tatagcgatg tctatcgaag tctacccagt ggtggttgcc gcgccggagc ttgaccgttc 52260 gggatcgccc ctcgaacacc acagtgcctt cgtgagttaa aatatgttcc gccatcgaat 52320 gttcctttat aacgtacagt tatgctttac ctctgcgcag gaagagtata ctatcagctg 52380 actcgccaaa gcgagcgaat ttaatccaac tttacttcgg caggaaagtg gccgatacta 52440 gcgccgccgc ctgtactgcc ctccaaaaca gaggatacat taaatgcaag aatgcaagat 52500 ttaccgcgac caactcccgg tcggtaaccc gaatcccaat gtcgacaaga cccgcgaccc 52560 gaaccttaag cccggtttcc tgcgtcgcag tcgcgagctg gacccggcgc tggccgttcg 52620 catccgtcgc gagctgatcc acgccgaagc atccgacttg gccaaggccg gatgggtcaa 52680 ttcacagtcc agcctttatg gatcgaaagc cttcccgcgc cattccgtcg ttcgcgtgac 52740 cggagttccg gaagatggag ctttcatcgg catgctgatc ggcttcatcg agcatcgcga 52800 gcatggcgaa tgggcggtca tggaagccgg aacgaaagaa ggcggcgccg tcattattcc 52860 agtcgatcac atcatgcgag cgtcattcgc cgaagccgaa gagttctctg aaaagtggga 52920 gcggaacctg ggatggcgtc tgctgcgcca gctccgcgag tgcggcgccc ttgccgggac 52980 tgaagacgag tttctgcggc ggatcatcaa tcgatacgtt cgtgatcgca cgatcctcga 53040 tcaccacaaa gtcggcgcgg acaaaatcta cactgatgca gtgctcaaaa gcatcggcga 53100 aacatggccg aagattcctt cggggaaatt cgtcggacac cgagtcgcgc agctcctgat 53160 cggccacaag ctaggtcgag cggggaccat cctgaatgac ctggtggact tcttggagaa 53220 gttcgcggcc gggcgcgata aagttctcaa catcgccatc tgtaattgag gtgaatggca 53280 tgtataataa accgactttg aatcaccacc atcaaaccgc attgttatat ctgtataaca 53340 atcccgatca gccggccttc acagacccca acaatcaggc gctaaatgaa cttcggcaga 53400 tggggtatgt aaaggcgaaa aaattcgaaa actgggcagg caccggccat cttaggatgg 53460 aatggacgct caccaaggcc gggattgagc gcgtcgaagt cgggtttctg gggaagtgcg 53520 ccgcttgcaa gggaatcggt cagacgttgc ttcgggggaa gtgtactgtt tgcaatggcc 53580 gcggccaggg gtggatcagc gaatggtcgc agaagccaat cgaagataat cctcaaatcg 53640 tcccaaagtt cgaaaagaca gatgcgaatc ggctagcaga cgccattgaa gaaatcgccc 53700 ggctggaaaa ggcactggcc gaatccgaaa agcgcgggag cgaactggcc gcgagctatt 53760 gcgatggcgt gatcggcgat gaatacggcc atcctcattg tcgttataaa gtggagcgcg 53820 acgccgccct ggccgaagtc gagcgcctgc gagaatcaaa aggcgatccc tctggcagct 53880 tcgacagatg tatgaagatg atgtacgagc gagacgagaa agcaaaacag ctggaagtcg 53940 ccctggccag ggtcgcggag ctggaaacgg ctctggcacc attcgcagcg gttgcccaac 54000 cacagccgtg cacgcaacca caggcccatc ctgctcgctg tggttgcgag cggtaagtgc 54060 caagtaagga gttcatgtaa tggaacataa gaaaccttca ccagtagatg gagtcatcat 54120 gaccagcctc gacgttctcc ggaaagcgaa gcccgaagca caggacgagt atgccgtgtc 54180 catgttcgca acggcgattc gccagaaact gcaacgctcc cgcgataaag gccgaggcgg 54240 ctggatcgac tgcgacgaag atattctgat caacggattc gccgaacatg cgctgaaggg 54300 aaatgagaac aacctcttgg acctggcgac gttcctgatg ttcatgtggg tgcgcggcat 54360 cgatgatgcg aagattcccc cggcgctcga aaaggcgcga cagcacaaga tcatggaagc 54420 ctggagtcga atccatgaag atggcctaaa ctccgccaga aaggcgagtg ctgcgcgaca 54480 gttcgtggaa gtgcctcgac gcaaggggcg cccggagcga cttgcatgaa gcctcacgaa 54540 ataagactgg cacaggccga agagttcctg cgcgaactcg gccgagggat tccggacgac 54600 gaacgggtaa tggtcggcta cgctgaagag gccacagtcc aaaccgacga gaacggccgc 54660 aagctcaacg ccggctggtg gcccgtgccc tggaaggaag gcaagtacat caattccaga 54720 tccaacgcat atgcctgtat ctcgtcgtcc atcaagacgc caaacccgaa gaccggccag 54780 atgcgatact ggcgcggcga ggcctctttc ggccacggcc tggcgttaat ggtcgatgac 54840 atcggctccg gcaaagggtc caagggcgac ttcgaccgcg acgagttccg cgagcgccta 54900 gagccgaccg cgattgtgga gacttcgccg aacaactacc agttctggta tttcttcaaa gagccgatgt cccacatgct ccagttcaag gcgctgctct attcgttcgt ggaccaggtg ctaaagaag gcggcgacaa caccgtcaag gacgtcagcc gttacggccg gatgccattc ggcttcaaca acaagcgcgg gaaagacggc aagttcaaat atgccgacga aaacggcaag cccgaactcg tgcgactgtt cagtgccgac tattccaagc gctactcgcc agaagagatc gcccaggcat tcggcgtccg catcatcatg ccacagatga agaaggtgga gataaccgc gacgattggt tgtatgacca agtatggttg aagtatgccg agcacatctg cacgaaatac aagatgggag aagcggcagg cggccaggtc cagcagaata tgtccggcaa ataccgcatc cgctgtccct ggggcgacga gcacaccac ggcgatcctt tcggcgcata ctttcgcgga 55440 ccgatacctg gcgccgagca cgaatatgtg ttcggatgcg ggcacgatac ttgccgcaaa 55500. gagcatcgac ggacatgggc ggccttcacc gatgaagtcg tgctacccta tatcgtcgaa caattggaaa gaatcaacca ccgtcacatc ggtgaggagt agacaatatg caaaacgatc 55620 ctggaatcct gatcacggcc attggcttgc tgttcctcgg ccttatcatc ttcttcgaag 55680 gcctaaaggg atggaaaata caagtcgcaa acttcctcgc gtcgcttctg tgctttttct 55740 tcggccttc tgctttgacg ttctggttcg tcgttgcgtt tgacgtattt taatcgacga 55800 acggtacaga aatttcgga tggggacgga acttattagc tatgccggtt taggtaggag 55860 ataatagccg tccctttcgc ctcaatatgt agaggcaatg ttgaatccga tcatgtaaag 55920 cagaaggcgg caaacctaac atgattatcg acgaagataa tatttttgat gatggcgaat 55980 cagggtccag tgagtttgat ctcacacaga tagaagatgc tggaatggac cctttgatga 56040 ccgccgcaag taagcggcc gacgatgcga ttgcgaggaa tgagacgtac cgagcacaaa 56100 aggcagcaaa gtatgccgag gcgtatgcgg aaccagattt gaagaagcga gcgcgattgc 56160 tgatgctcga tcaggccttt gatcttccgg tcagccggct ggtgaaagga ccgttcgatg 56220 acttcatcac caagtacagc tcgacttcag acagcaacta cctcgcggtc tatgacacgt 56280 tgttctgtaa gggcgacgga accgtcccac acccgcactt cgacgagttt cgcggccggc 56340 tggtggacca tcgcggcgtg gcgttcaaca acaagaccct cgatccgatt gacctgatgg 56400 gcgccctcgc ggctgcggcc ttggacgatc cctcgattaa gaagacgatt gagacttgct 56460 gcgtttgggc gcgtcgatat cgccgcaact cgctgatcga gacgtttgag aagaagatac 56520 cggattggga cggcgaagag cggatcgaaa cgctgctgat cgacttgttc aaaccgttcg 56580 acaccgagct taaccggatg gtgagcaagt atttctggct gagcttgtac tgccgcatca 56640 actaccctgg aatctcggcg ccgatctcgt tggcgttgat tggtgggcag gatgcgggga 56700 aatcctattt cggcctgctg atctgcaaag aactgtctgg cggtcgcgat ctggctccag 56760 tccagctcga tctgagccga cacgaccaga cgccattcct gcgcaatatc accggcaact 56820 cggtcattgc gaacgtcggg gaaatgtccg gcttcaaaaa gggcgacatg gagcgcatca 56880 aggagttctt ggttcgttct tcggatacat tcgaccagaa gtttgagccg ggagaaacga 56940 tcaagcggca atggatcacc atcatggacg gcaacggata cgatggactc cagcgggacg 57000 actccggcaa ccgtcgattc tatccgatgt tcgtggcaca acttccccgac gaagatggaa 57060 agccgaactg ggttaagccg ggcgatggta atgaaccgtt caaggtggac ttcaccgact 57120 tcggccgcaa attctggcaa gcgatggctg aatgccgcgc atggatcgaa gagcatggtg 57180 tcgatggata cctggatatg gtgtcggaag cgaaccgcga agtgcagaag ttctctatttt 57240 cggaaatgga gaatgcgcgt ggcgtggttc gtgatgacac gattgatatg tatctgatca 57300 acgtgctgat cagttgcgag ttcgaagaga tcaagcctgg caggaattca aagaatcctg 57360 gatggagagt tgacactgta gccattctga aatggttcga catcctcgcc aggaagaagc 57420 cgatttctcg tcaccttact ccgcacttga aggcgctggg atttgtcccg aataagaacg 57480 gcctgaatgg atggtgctta cctgtcgata aggttgcacc tggatggacg aagggtatgc 57540 atatgacact gccgccgttc aatgatgcgc ttgtgtactt gctgagaaag ggcgacccgg 57600 acatcactga tgaggctgca atgacaaaga ttcgggcggt acgggccgag cgagctaaga 57660 ttttgggcga ggatttctga tgtagtggtg gagtgtactt ggactaggcc gccttcgggc 57720 ggtcttttct ttggtgcggc gtacattcga tttcggtggc ggccgagtga gattcggaag 57780 ctatccggta attaggatgg gatggtggtg gcgtattgtg gaaagttcgt ggatggtgga 57840 tcgagaattt tgtgtggtga gggggtggat tatggaaaat cgacgattct gactggattt 57900 ttggggtcgg ccgcgtcgag cttaccggta atttacgaaa ccaggaatta gggtcgagcc 57960 ttagtgccgc gtgggcttga agcgctttcc cggatacttt ccggattcgg aagcagccgc 58020 aaaactatac tacagcgaaa atcgattgca caatcctaat agaaaaaatc tatcacggac 58080 gttacctatc ttaaaatta ataaaattaa tagtaatttg gtaatttggt atactttagt 58140 atttgaaagc cttgcggcac taagcctgta cacttccct caagtttccg attccgctca 58200 actcgcggca gggtcgccgg aaacttccgg acttacaatc catgggtcgc ggcaacacca 58260 cggcggacta agcggcaagt gccaaaactc gacgaacgga accggaaatt tgggagcgcg 58320 acagaatagc tcagctggac atatttctaa cattcgattt aacactcaat ccaaacactc 58380 accaccatcg tctcccacca acagccgact cgaccctcac ccaccagcag accgcccata 58440 taacatccta taacaccacc taacactcat tcaccatcaa acccacccag acctacagcc 58500 cacccacaag cagcccatag acgcgatccc tggccccata gtacaatcgc gccatactca 58560 gtgtcgcggc agagcaccag gggccatccg ccaaccaagc caccacgacg actccagaat 58620 cgaactccag ggacgcagca acaaatgacc gccaaattct acagccccga cgatttagtc 58680 acgccacagg aattcgcaga cccgcatttc gcggcgatca accaaaagcg attcgacctg 58740 tacatcgacc tgcgcgtcca aggctacagc tcctggcggg tcttccgagc catctggggc 58800 gaggagcata tggacggtcc cgctcaggcc cgcatcttcg cgatggagtc caatccgtac 58860 tatcgcaagc agttcaaggc caagttgaac gcgaccaaaa cgtccgactt gtggaatcca 58920 aagacggcgc tccatgaact cctccagatg gttcgcgacc caaccgtcaa ggattccagc 58980 cgtctgtcgg ccatcaagga gttgaacgtt ctggctgaaa tcacgttcgt ggacgagtcg 59040 ggcaagacca ggatcggtcg cggcctggcc gacttctacg catcggaagc cgaggctcag 59100 accgcgaccg tcgctgctgc ggccgaagcc aatggatatg tgccggaagg tgaagaggga 59160 gatttcccgt ctccgtctcc ggaaccgacc gaggaagacc gcgccaaccc catttagaca 59220 taaaataaca tcattctagg cccgaatcgg accgaactaa ggcgaaggta gcgggaaggg 59280 acgaaaaacg attctagggc ggttctagga agttgacgcc taaccctcag aaactacaaa 59340 ccccggactc tagttcagaa tccggggttt tcttttgggg ttcttattcg ccagtttcga 59400 tgatttcgaa gttgtatttg acgccttcgt gctcgaaggt caacttgcct gccgctttca 59460 gttgcatgcg gaatcggatg cacttagagg aaggcaaacc gaactcgatg aaggctgcgt 59520 tgcaggattt gaactctccg cgcttgcctt tcacggtgac cgctacgcca tgacgctcgg 59580 tgcgcttgcg ggcaacttct gggtctttcc aggagttggc tatggctgct gacaggtctt 59640 tggtctcttt ggttttctcc ggcgcgttct tcgcctcttc gcgcattttc cggatttctt 59700 ccagcgcttc ctcttcggtg atttcttctt ccggcttcag attctcttcg gccttctctt 59760 ctgccttctt cttggaagtg cgggttttgt aaacctttgc cggggcttcc tcttcctgga 59820 aggcttcttc ctcggccggc agagcattca ggatggcgag gcagcgacgc tcagcagtct 59880 tgcggtcaga gaaacgcttg acggtcgcat cggcgttgtg ggcgttgtag aaggcgacca 59940 gttctttcat ttctgcgtcc tggatgtcgc cgaaggtttt gatggagttg gtcattttgc 60000 gatcctctgt tttggaagat ttcgtttggg cttcagtttg tcgccccgtt gaaagagatt 60060 atgcctaggt cgatgctgcg tgtctacatt tatttagcag aatgatggtg aacccgacga 60120 acggtcgtcg gatgtgaaaa caccgcagag caggctgcgg tgtttgttgg cgttggggtg 60180 atgtcagaaa gtcgggacgg tgataggctc gatgggcgga tcgccgggcc tgtcgttgtc 60240 cgatgcgggc gccgggctgg aagggatcgc acccgaccga agcgccagcg attccgactg 60300 cctgcttacc tgtggagctg gaggagccgc tggtgccttt ggagggattg gaggcaggtc 60360 atttcgaccc ttgaccattt gcagaggttc tggaagatcg ggaagcgcgc cagcgatttc 60420 gccatacgtc cgcgccggat cgtcgccgaa catttcggcg gatcggttat ctttgacgat 60480 ctggctgatg gccgtcacat cgccgcccgg ttctgcagga tcgatgccca cgaatggagt 60540 ggtcacgcag cgcatgttcg gatgggtagg cagatttttc agaacgatgg agtctgccca 60600 gacatacgga ttcttgtggt tgccgggtcc gtggctgatg atctcggcag gaatatggcc 60660 gttcatggtg agccattccg ccatcccttg ccgagtcagc gggcttacca cgatctggcc 60720 agtggactct ttggcgatgg cgaacagatc accgaattcg aatccaatga ttgtgtagtt 60780 ggacctggac tcgccgacga aagccagagt ttcgatgttg tggtggatat cttgttcttc 60840 ccagatgtaa agcatgatgc gctcctcaat aaggctgctt gttgtattcg accagagaca 60900 taccggccgg aactttgaag cggacgtatt cgatcatcat cgccgtgcga cgccgattcg 60960 tgccagactc gtcattgacg aagagttcgc actgatgcgg aatgactcgc gtcaccaggc 61020 cttcgccttt cgagccgtag aacttgatgt aggctgcgac gcctcgcgtc atgttcagac 61080 ggatcgtttc gcagagtcgc tgcgcggccg acgcgctgga cagatcggtc ggactgaccg 61140 tcacccagta atggccactt tgttctttat cggacataag ctgccctcca atgagaaagc 61200 ctctgccgag tcgcataggc tggttgttgt tagtcgcgct tcaacagaac gactttgtca 61260 tatgcgcgat atttaccgcg ccagtcttcc cagtagtcgc cggccgggca ggtaagctcc 61320 agggtgattt cgtcgcgcca gcattcgaca gaaaggacaa ttgccttgtt cctggctgcg 61380 gaatccgccc tgagcttaat cagaatttcg tcgccagttt tcaactcatc aactctcaca 61440 actttggcca tgacacactc ctgtttgaag aggcgcggcc ggaaccaacc cagccgcgcc 61500 gatggattaa cgtttgtgaa ggatggacac tgcgtccacg tcgaggatgc tgatggtacg 61560 gcgacggcgc ggattgctgc gttcatggat gcgaatcagg ttcgcaactg gagcttcgtc 61620 caccacccat acatcttccg gcttctgcgt ccggagcagg accgtcactt ctgcgttctg 61680 ggcgaggccg ttgcagatga acgtgaactt ggacgaggga gttctgtaca tgtcgagatt 61740 cctttttgga cttcgggtcc ggcttttcag tcggtgaaga gattatgcct gatcatcacc 61800 gtcgagtaaa gcacttatgg accaattctc cagttaaatg gaaccaaagc gcggtatcgc 61860 tgatcgctac gcttccacgc catggccctt cttgctcaca gacttcgaac cacaagctaa 61920 tttccatcct ggccaggact cggccgaagg attcgagccg acgccggctg gccaggatgt 61980 cgacattcac ccgtcgatta atttcgtacc ggcgaccgtt gatgacgaag accaggcgca 62040 gggtgcgtcc gtccagacat tcccagtatt tggtttcata ccgaagccag tagcgcttgc 62100 cagccgggcc taccatggtc atttaatcga tgctcctggc cgcgccacgc ggtccggtcg 62160 gcgggacggg atcgaaccga cccaggatgt agtcgggccg gcgcgcttcc tgaggacaca 62220 cggcgagaag gcgccatcct gcgtccaggg cagactggag ttcgtccgtg cagcagtctt 62280 ccttgagcag cagacggttg acgttctgga gattcggacc aggtatggcc gatcctgtga 62340 gtgagttcca accttcgacg ccgtgcacca tctgcggttg gttgatgtag ccttcggacc 62400 tgccagccaa ccggcttgcg gccagctcca ggcgctccag catgggtcgc agagcggctt 62460 ccgggtcaac gtcgtcccag agaaggacca ggttgatgat ggtgtacgga tagtccttgt 62520 ccagatccca ggccgaagcg gtcaggcggc ccaggccgat ttcattacac atacggga cgtcgttgct ccaggtggac ggctcccagt tccgctcacc aggattcccg attgttacgc 62640 cttccaggtt ccccaggaga acgtggagct tgctgacata ttccgcctcc aaggctttcc 62700 gctcttcgtc ggtctggttg tggcgataga aggatggagg gctgactttg gcatggtaga 62760 gtttcatgat tgttcctttta tgtagggttc aacttcaaag aatttcgtcg cagaacttct cgaaaggact ccgccttttc ttctcgcagg cggcacaggt gatttccagg gccggaatct 62880. cgttataggt cttgccgaag tacagccagc gtttacatag gcttcgaccg tccgccatga 62940. agaagtgagc ttttcgagca gcgccggggtt gcgcccagcc gctcggcatc ttactggact 63000. tgttcatgcg gtctccctct tcggctcagg aatccatggt gtgatttcgt ccgcccattc 63060. cccatcgatg aacatcaagg acagaagacc atagcgcccg aagctgaagc ctacatagaa cgatccgggt tccacttcca tgctggcggt attgcgttct tcgatcatct ggaatcgaa 63180 cattgcatag ctcataccat caccatgtcg atttcattga tgaagaaatg gacatcgaca 63240 ccatcggcgc ggccggtgta acgcagccga gtcgtcccat caatgtgggc ttcctcgacg 63300 ccgatgactt ccaggatggt gtcgttgcaa tacagcttga cgaacatctt gatgccggag 63360 ccaatcgcct cgaaggcaat ctgcttgtac aggtcttgct tgatcatgct ttacgctcct 63420 gtttgcggat gtattctgcc ctgacttcgg cttcgaattt cgcccaaagc gcgttgtcga 63480 ctggacccca gggaccggtc tgagttccgt ccaccggtgc gaacttgcca ccggcgcggc 63540 gatatttgga cagagttttc aggctgatga tcttctcatc ttgggaatcg aattggacta 63600 tcatttgacg tacttcccga agtagcaggt gtggaggatt tccaggcctt tggagatagc 63660 cttcagcttg atgccgaaat tcttgatcgc ccagtccaga tcgtggtgat agaactcgat 63720 gatgttgacg atttgaccgg cgctgtagtg gatgacgcga accttgccgt tccagcggaa 63780 atcttcgcgg ctgtttacgg cctcgacttc gatggtgtcg tttctgccga tggtccattt 63840 ggagctagtc atgtcgcaat cctcttttg gagtgtttcg cgtttcgatg aggannnnnn 63900 nn 63902 <210> 2 <211> 66024 <212> DNA <213> Bacteriophage P1777 <400> 2 cgtcgacga cttcatcacc aagtacagct cgacttcaga cagcaactac ctcgcggtct 60 atgatacgtt gttctgtaag ggcgacggaa ctgtcccaca cccgcacttc gacgagtttc 120 gcggccggct ggtggaccac cgaggcgtgg cgttcaacaa caagaccctc gaccccattg 180 acctgatggg cgccctcgct gctgcggcct tggacgatcc atcgatcaag aagacgattg 240 aaacttgctg cgtttgggcg cgtcgatatc gccgcaactc gctgatcgag acgtttgaga 300 agaagatacc ggattgggac ggcgaagagc ggatcgaaac gctgctgatc gacttgttca 360 aaccgttcga caccgagctt aaccggatgg tgagcaagta tttctggctg agcttgtact 420 gccgcatcaa ctaccctgga atctcggcac cgatttcgtt ggcgttgatt ggtgggcagg 480 atgcggggaa gacttacttt tcaatcttga tctgtaaaga gttgtcgagc gaccgaaagt 540 tatcgccggt ccagcttgac ctgagccgtc atgaccagac gccatttttg cgcaatatca ctggcaactc ggtgatcgcg aacgtcggcg aaatgtccgg cttcaaaaag ggcgacatgg aacgaattaa agagttcctg gtgcgatccg atgatacttt cgatcagaag tttgaaccag gcgaaactat cagccgacaa tggatcacca tcatggacgg caacggctat gatggtcttc 780 aacgggatga gtcaggaaac cgtcgatttt atccaatgtt cgtggcgcaa cttcccgacg aggatggcaa gccgaattgg gttaaaccgg gcgatggaa tgaaactttc cgcgttgact tcaccgactt cggccgcaaa ttctggcaag ccatggctga gtgccgcgcc tggattaagg cgaatggcgt ggagggatat ctcgatctag ttcgggcgac caacaacgaa gtccagaaat tctctatttc ggaaatggag aatgcgcgtg gcgtagttcg tgacgatacg attgacatgt 1080 atctgatcaa tgttctgatc agttgcgagt tcgaagat caagcctggc aggaatgcca agaatcctgg atggagggct gataccgtcg ccattctgaa atggttcgat attctcgcca ggaagaagcc gatttctcgt caccttactc cgcacctgaa ggcgctggga ttcatcccga ataagaacgg cctggctggt tggtgcttac ctgtcgataa ggttgcgcct ggatggacga 1320 atggcatgca cacgacgttg ccgccgttca atgatgcgct tgtgtacttg ctgagaaagg 1380 gcgacccgga tatcactgat gaggctgcca tggcaaaaat tcgggcagtc cgggccgagc 1440 gagccaagat tttgggcgag gatttctgat gtagtggtgg agtgtacttg gactaggccg 1500 ccttcgggcg gtcttttctt tggtgcggcg tacattcgat tccggtggtg gccgagtgag 1560 attcgaaagc tatccggtaa ttagggtgag gtggcgatgt tgcattatgg aaagttcgtg 1620 gagggtggat cgaggatttt gtgtggtgat tgggtgaatt gtggaaaatc gccgattctg 1680 actggatttt tggggtcggc cgcgtcgagc ttaccggtaa tttacgaaac caggaattag 1740 ggtcgagcct tagtgccgcg tgggtttgaa gggcttaacc ggatactttc cggtttcgga 1800 tgcagccgca aaagtatact acagcgaaaa tcgattgcac aatcctaata gaaaaaatct 1860 atcacggacg ttacctatct ttaaaattaa ttaaattaat agtaatttgg taatttggta 1920 aactttagta ttgaaagcct cgcggcacta atcttgtaca tatcccgtca agtttccgat 1980 tccagccagc tcgcggcagg gtcgccgga acttccggac ttccaatcca tgggtcgcgg 2100. 2100. 2100. 2100. 2100. 2100. 2100. 2100. 2100 ggcgcacgac aaaatagctc agctggacat atttctaaca ttcgatttaa cactcctctc aaacgctcac caccatcgtc tcccgccac cgccgactcg atcctcaccc accagcagat cgcccgtata acatcctata acaccaccta acactcattc atcatcaaac ccacccagac ctacagccca cccacaagca gcccatagac gcgatccctg gccccatagt acaatcgcgc catactcagt gtcgcgacag agcaccaggc cccatccacc aaccgagcca ccgcgacgac tccagaatcg aactcaggga cgcagcacca aatgaccaaa tactacagcc ccgacgatct agtcacgcca caggaattcg cagacccgca tttcgcggcg atcaaccaaa agcgattcga cctgtacatc gacctgcgcg tccaaggcta cagctcctgg cgggtcttcc gggccatctg 2580 gggcgaggag catatggacg gtcccgccca ggctcgcatc ttcgcgatgg agtccaaccc 2640 gtactatcgc aagcagttca aggccaagtt gaacgcgacc aaaacgtccg atttgtggaa tccaaagacg gcgctccacg aactcctcca aatggttcgt gacccaaccg tcaaggactc 2760 cagccgtctg tcggccatca aggaattgaa cgttctggct gaaatcacgt tcgtggacga 2820 gtctggcaag accaggatcg gtcgtggttt ggccgacttc tacgcatcag aagccgaggc 2880 tcagaccgcc accgtcgctg ctgcggccga agccaatggc tatgtgccgg aaggcgaaga 2940 gggagatttc ccgtctccga cgccggaacc gaccgaggaa gaccgcgcca accccattta 3000 gacataaaat aacatcgttc taggcccgaa tcggaccgaa ctaaggcgac ggtagcggga 3060 agggacgaaa aacgattcta gggcggttct aggaagtcgt agcctaaccc tcagaaacga 3120 caaagccccg gactctagtt cagaatccgg ggctttcttt tgggcgcctt attcgccagc 3180 ttcgatgatt tcgaagttgt atttgacgcc ttcgtgctcg aaagtcattt tgccagccgc 3240 cttcagctgc atgcggaagc ggatgtgttt cgaagaaggc aggccgaact cgatgaatgc 3300 tgcgttggtg gaccggaact cgccgcgctt gcctttgaca gtcacagcca cgccatggcg 3360 ctgagtgcgt ttcttggaaa cttccgggtc tttccaggag ttggcgatgg ctgccgacag 3420 gtctttggac tctttggctt tctccggagc gttcttggcc tcttcgcgca tcttcggat 3480 ttcttccagc gcttctctctt cggtgatctc ttcttcaggc ttcagattct cttctcggc 3540 cttctcttct tccttcttct tggaagtgcg ggtttgttaa accttggccg gggcttctc 3600 ttcctggaag gcttcttcct cggccggcag agcattcagg atggcgaggc agcgacgctc 3660 agcagtcttg cggtcagaga aacgcttgac agtcgcatcg gcgttgtggg cgttgtagaa 3720 ggcgaccagt tctttcattt ctgcgttctg gatgtcgccg aaggttttga tggagttggt 3780 cattttgcga tcctctgttt tggagaattt ctttcgggct tcggtttgtc gccccgttga 3840 aagagattat gcctaggtcg atgctgcgtg tctacattta tttcatcaga tttatcgcaa 3900 agccgacgaa cggttgtctg atgtgaaaac accgcagagc aggctgcggt gtttgttggc 3960 gagggcgatg gtcaagcgaa cggatcgccc agcatatctt cagacggggc acgttgcata 4020 tcgcccagct tgtctttgtc agttgccgga ctggacggga tcgcgccgga ccgaagcgac 4080 agagattccg actgcctgct cacctgcgga gccggaggag ccggaggagc cggaggagcc 4140 ggaggagccg gaggagccgg aggagctttt ggcgcagtag gggcaggcgg gaccggcagg 4200 cctggaggag ccatcggcgc catgggcggt tctggaagat caggaagact cggcgctatg 4260 ctgccaaagg accgctgcga ctgctgcgcc ggattgtcgc cgaacatttc ggcggatcgg 4320 ttgtccttga tgacttgacc tatggccgtc ttgtcgccgc ccggctctgc cggatcgaag 4380 cccgtgactg gcctggttac gcatcgcatg ttctgatggg tcggcagatt tttcagaact 4440 atggaatctg cccagacata cggattcttg tggttgccgg gtccgtggct gatgatctcg 4500 gcaggaatat ggccgttcat ggtgagccat tccgccatcc cttgccgagt cagcgggctt 4560 accacgatct gaccagtgga ctctttggcg atggcgaaca gatcaccgaa ttcgaatccg 4620 atgattgtgt agttggacct ggactcgccg acgaaagcca gagtttcgat gttgtggtgg 4680 atgtcttgtt cttcccagat gtacagcatg gttcgctcct caataaggtt gcttttggtg 4740 ttcgaccaga gacatgccgg ccggaacttt gaagcggacg tattcaatca tcagcgccgt 4800 gcgacgccga ttcgtgccag actcgtcgtt gacgaagagt tcgcattggt gcgggattac 4860 tcgcgtcacc aggccttcgc ctttcgagcc gtagaacttg atgtagaccg cgacgcctcg 4920 cgtcatgttc aggtggaccg tttcgcagag tcgctgcgcg gccgacgcgc tggacagatc 4980 gtttggactg accgtcaccc agtaatggcc actttgttct ttgtcggaca taagctgccc 5040 tccaatgaga aagcctctgc cgatccgcag aggctggttg ttgttagtcg cgcttcaaca 5100 gaacgacttt gtcatatgcg cgatatttac cgcgccagtc ttcccagtag tcgccggccg 5160 ggcaggtaag ctccagggtg atttcgtcgc gccagcattc gacagaaagt acaatcgcct 5220 tgttccttgc tgcaccctct gcggcatctg ctctgagctt aatcagaatt tcgtcgccag 5280 ttttcagctc atcaactctt acaactttgg ccatgacaca ctcctgtttg aagaggcgcg 5340 gccggaacca acccagccgc gccgatggat taacgtttgt gaaggatgga cactgcttcc 5400 acgtcgagga tgctgatggt acggcgacgg cgcggattgc tgcgttcatg gatgcgaatc 5460 aggttcgcag ctggagcttt gtcaaccacc catatatctt ccggcttctg cttccggagc 5520 aggaccgtca cttctgcgtt ctgggcgagg ccattgcaga tgaacgtgaa cttggacgag 5580 ggagtcctgt acatgtcgag attcctttttt tggacttcgg gtccggcttt tcagtcggtg 5640 aagagattat gcctgatcat caccgtcgag taaagcactt atggaccat tctccagtta aatggacca cagcgcggta tcgctgatcg ctacgctccc acgccatggc ccttcttgct tacatacttc gaaccacaag ctgatttcca tccttgccag gactcggccg aaggattcga gccggcgccg gctagccagg atgtcgacat tcaaccgccg attgatttcg tatcggcgac 5880. 5940. cgttgatgac gaagactagg cgtagggtct gtccgtccag acattcccag tatttggttt catgccgaag ccagtagcgc ttgccagccg ggcctaccat ggtcatttaa tcgatgctcc 6000. tggccgcgcc acgcggtccg gtcggcggcg caggatcga ccgccccagg atgtagtcgg 6060 gccggcgcgc ttcctgagga cacacggcga gaaggcgcca tcctgcgtcc agggcgtact 6120 ggagttcgtc cgtgcagcag tcttccttga gcagcagacg gttgacgctc tggagattcg 6180. gaccagggat ggccgagctg gtgtgcgagt tccaaccttc gatgccgtcc accatctgcg 6240 gttggttgat gtagccttcg gacctgccag ccaaccggct cgcggccagc tccaggcgtt 6300 ccaacatggg tcgcagagca gcttccgggt caacgtcgtc ccatagaagg accagattga 6360 tgatggtgta cggatagtcc ttgtccagat cccaggccga agcggtcaga cggcccaggc 6420 cgatttcatt acacatcacg ggaacgtcgt tgctccaggt ggacggctcc cagttccgct 6480 caccaggatt cccgattgtt acgcttcca ggttccccag gagaacgtgg agtttgctga 6540 cgtattccgc ctccagcgct ttccgctctt cgtcggtctg gttgtggcga tagaaggatg 6600 gagggctgac ttttgcatgg tagagtttca tggcggttcc tcggtttttg aaggcttgaa 6660 cgttagagaa tggtgtcgca gtatttctcg aaaggactct ggcgcttctt ctcgcagatc 6720 gcgcaggtga tttccaggtc gggcagctcg ctgtaagtct tgccgagata cagccagcgc 6780 ttgcacagac tgtggccgtc cgacgtgaag aagtgagctt ttcgagcagc gccgggttgc 6840 gcccagccgc cttgatcgtt tttgcgcttg ctcatgacga tatctcctct ggatcgggaa 6900 tccatggtgt acgttcagtc acccaaactc catctacata gatcaggact gacagagcag 6960 tcgcgccaaa cccgaagcct acatagaatg aaccgggatc gatttccatg gtggcgctat 7020 tggtggtgct attgcaatcg acttcaaagt cgaatagcga atgaccaatc ataccatcac 7080 catgtcgatt tcattgacga agaaatggac atcgacacca tcggcgcggc cggtgtaacg 7140 cagccgagtc gtcccatcaa tgtgggattc ctcgacgccg atgacttcca ggatggtgtc 7200 gttgcagtaa agcttgacga acatcttgat gccggagcca atcgccgcga aggcgatctg 7260 cttgtacagg tcttgcttga tcatgctttg cgctcctgtt tgcggatgta ttctgccctg 7320 gcttcggctt cgagcttcgc ccaaagcgcg ttgtcgactg gaccccaggg accggtctga 7380 gttccgtcca ccggtgcgaa cttgccaccg gcgcgacgat acttggacag agttctcagg 7440 ccgatgattt tctcttcttg ggaatcgagt tgggcgatca cttgacacac ttcccgaagt 7500 agcaggtgtg gagtatttcc aggcctttgg agatagcctt cagcttgatg ccgaaattct 7560 tgatcgccca gtccagatcg tggtgataga actcgatgat gttgacgatt tgaccggcgc 7620 tgtagtggat gacgcgaatc ttgccattcc agcggaaatc ttcgcggctg tttacggcct 7680 cgacttcgat tgtgtcgttt ctgccgatgt tccatttgga gctagtcatg tcgcaatcct 7740 ctttttggag tgtttcgcgt ttcgatgagg taactatacc tcagtcacct catcgagtaa 7800 agcactttcg aacagattat tgaaatttct tgaagacaga tcaatcggac gcgtcatcga 7860 tatcgaacgc cgagcgcgcc aggttgatga tctctggcca ggtcaaggtg aaggctttgc 7920 cgtcatcacg aatgataatg ggagtccgca gcggctcgcc caccagcatt gtgtaggtat 7980 gtttctcgcc ggatgcggag ccgatgcggg tgcttaaggt gagcggggat tctttgtgta 8040 cggtgccgat cattgtttcg ttcctcggtg atgcccggag aatcgggctc gttggattag 8100 gctttgccgc gacggattgt tacgccgcat tcagtagtca ctcccttagc ggcaggatcg 8160 cgaacaagat aagcacaggc ggctttgaca ttcagagttc gggttacgcc gagtttgcag 8220 gaaagatcgt tcccttcttc gtcccacaga tgggcgatgc gagaggtaca gcctttttct 8280 acttcggctt ctacagttac ggactggtca atgttgaata ccggcatcgc tttctctccg 8340 aggttgttcc gtttcaatga ggtgactata cctaagtcac ctcattgagt aaagcatttt 8400 cttcagatta tctgaaacct tttgaagtca ggaactgccg ccagagccag tcgatgtgtt 8460 cgttgcagta acgctcgcca tcggacgaca tagccagagc accatccttg atgccgaacc 8520 gggtaacggc gagccattcg aatccgaact ggagcgttcc tgggcgaggg atatgggaca 8580 tggcgtattt ctgcacggtc agtgatcctc agaaggtttc gcgtttgcga tagccgctac 8640 tttctgcata ccgaggcgat agaaatcggc ttctttcctg gctttggtaa gctgctccat 8700 ggcgtcgcac gccgtcttgt gctgggaatt ggcgttcttg atgctgccgt ccaggctctt 8760 gtctaactct tcccgaagag ccttctgcga tgctagctcg gcctccaaat cctggattct 8820 gagttgaagc tggcggttct gctcggcgac cttgtcttcg cgggctacga agttctgcag 8880 gcggtcgaca agacgagtat tttcgcgcac cagctgctgt ttggcgactt tggtccttcg 8940 cagttctgct cgcaatgcgg acaactccag cgcatgcaga tcggcgtccg attcttgcga 9000 ctctgcggcc tgcttattgc gcagatagta ttgcccagcc gcgaaggcga gcagtgctcg 9060 gtctgtatcc ttaactgtct tggccatgaa gtgggctcga tacagaggcg cgaacttgca 9120 ggcgtctggg tcccaggcca gattatcggc cacaggccag aatgcgcgaa agcttttcgc 9180 atcgacatgc gccttgaccg tctgcgatgc gcccgactct tcgcagatga tttccagagg 9240 gacataaatg gcgttcttga tgcttcggaa agaaatggtg gacataacac aatcctcata agaagtcgcg gccgggacca tcctggccgc gcatcgtaat cactcttcgc cttcgtccgc gctcagccac tcttcgaagg cgaattcac cttcgactcg acccaatcct gcagctcatc ggcgaactcg tcactgtcga tgtccatggt gattcccata acttccatgt tccatagcgc 9480 ggcattcagt tcgaactgca ccatctgctc gccatcgact tccagcagga tgcggtctgc 9540 gacttcatag tcgtctacat cgaacagatg gccgcccgcc aggaggtgct gtacgaaagc ttcatcgagg ttggtgactt cgatctggac ttgtttggtc attttcgtat ccttacttag 9660 cggctttgaa ttgggctttg aggttggcca gttcagcttt cagatcgatc atcgcctgac 9720 cgcgcaggcc ttccatttca gcctcgctga ttgcgatctt ggctgcgcgg attttgtcgt 9780. tgatttgatc tttagtcatt tttcggcttc cttttgtttg aagggtttcg cgtttcgatg 9840 aggagattat gccgatagtc agaatggaag taaagtgtct gagtgaagaa atttctgtac accgacgaac ggttgcgctc gaccgtctgc tgcggtgtcg atatactcgg cctattgcga 9960 acaatggact gattaaatgt tcaagctcaa tcctgcactg cgagcggtct ggcgaactcg 10020 tgcccgttac aaagtcatct atggcggccg ggcgtcttcg aagtcgcacg acgctggcgg 10080 tatagccgtt ttcctcgcgg ccaactacaa gctcaagttc ctctgtgctc gccagttcca 10140 gaaccgcatc agcgaatcgg tctacacatt gatcaaagac aagatcgaaa actcagagta 10200 taatggcgaa ttcatcttca ccaagaactc catcaagcac aagattaccg gctcagagtt 10260 cctgttttat gggatcgccc gtaacctgtc ggaaatcaag tccaccgaag gcatcgacat 10320 tctctggctt gaggaagctc actatctgac ccaggagcaa tgggaagtca tcgagccgac 10380 catccggaaa gagaactcag aaatctggat catcttcaac ccgaacgaag tgaccgactt 10440 cgtgtatcag aacttcgtgg tcaagccccc gaaagattcc tgcgtcaaga tgatcaactg 10500 gaacgaaaat ccgttcctca gtgagacgat gctcaaagtg attcacgaag cttatgagcg 10560 cgaccgggag caggccgagc acatttatgg cgggattccg aagactggag gcgacaaatc 10620 cgtcatcaat ctcaagttca ttcttgcggc catcgacgcc cacaagaaac tcggctggga 10680 gccggccgga tcgaagcgca tcggcttcga cgttgcggac gacggcgagg atgcgaacgc 10740 aactacgctc atgcacggca acgtcatcat ggaagtggac gaatgggacg gcctggaaga 10800 tgaactgctc aaatcgtcca gtcgcgttta caacctggcg aagatgaaag gcgcatcggt 10860 cacttatgac tccatcggcg tcggcgctca tgtcggttcg aagttcgccg agttgaacga 10920 tgccagccca gacttcaaac tgatctatga cccattcaac gcgggcggcg ctgtcgataa 10980 gcctgatgac gtctatatga agctgccgca cacgacgatc aagaacaaag accacttcag 11040 caacatcaag gcgcagaagt gggaagaagt cgcgacccga ttcaggaaga cttatgaagc 11100 ggttgagcat ggaaaggttt atccatttga cgaattgatt tcgatcaact ctgaaacgat 11160 tcacccggac aaactaaatc aactgtgtat cgaactttcg tcaccgcgca aagacctgga 11220 catgaacggc cggttcaaag tcgagtccaa gaaggatatg cgcgagaaac gcaaaatcaa 11280 gtcaccgaac atcgctgact cggtgattat gtcggccatt ctgccgatcc ggaagcccaa 11340 aggcttcttc gacttctaaa catagaaaag cccggatcgc tccgggcttc gggtcttact 11400 cggtgcggtt cctggcgctg agtgtcgacg caacggcctc gccgactccc agggcttcct 11460 ggccggccgc gagcgcttcg gcttccgact cgacgatgaa atcatcacct tggccatcgc 11520 ctggcggaac ctcgaccagc acggcttctt cgccttcgaa ccgcaggtca taggtctttt 11580 cgacggacag accgtaacga gcgttgagcg cgtcccagag ctgggcctca taggtccgca 11640 ggtcttgcag agctttctgg tggctgagca tggccatgtc aacggcccgt tgcagggttt 11700 cgtccaggac gttgaatcga atgcgaagag aacgaatccg ctcgacgact tccgcatcca 11760 ctacatgtct ttcgatcatt gcttttcacc tttgctgaat gtaacgttgt agccgttgtc 11820 ggccaggtag gtcagggcgc cttcgaagga agttccgacg aggtgcttta gcttcatttc 11880 gcgttgcgcg gccagccaga atgcagttcc ggagaactcg gcgcggcctt cggccaagac 11940 cctgccatca ggcccggcga tccgtacatt gacggaagat agcttgatcg gcatcagtga 12000 atacctccac tggcttgcga cggcatgctt tcggcgcgag cagcttcgca gtccgggcag 12060 ggacaggctt ggcggacgcg ctccagctcg tcggcatcca tgacatagag cttcccatcg 12120 gcagtgtcgt gtgccatggc gatgttcggg aagtcggtgg cgctcaggcc ggcgacagcg 12180 cggatttcgt cccagagcac cagatgctcg gcattcaggc gggcggcgag cgcttcatgc 12240 tctttagcga cgcgcgccat gaactcgtcc atccggaatg cgaattccgc atcgatggca 12300 cgggccgagg ccatggagct gagtcgaatc ggttctttct tcatgatgat tctcttttgg 12360 ttggtggttg ttcgctgccc aggcctattc acggcctggg cagcacgatg aagatgaaca 12420 caaaggctgc aaacgccaat agcgttccgg caagcatttt ggaatgactc tgcatctcag 12480 cgtactgctt agtggacatt ccgtgctgcg ccgcctcggc cgcgaagcgg gctttcgcct 12540 cgataacttc cgggcgcagc gacaggacat attctaaggc ctcttcccgc gctttttcgg 12600 cctcgaccga cctagggtcg cgggccgaga cttcgctgtg ccctggcctc gcgggatggg 12660 cttgcagcga tggagggagt tcagccgcca cgactccata gtctgcgcag gcccaagcga 12720 tcccgatgag gatcgcgagg atggattgga cgattcgcag catcactttg tcgctaggga 12780 agttcatgat caatcctcca ccgaccgaac gatttccatg ttacgcccgg cattggcccc 12840 tgcattgaag gcgcgccgac cgtcgctatc gtccagacgc atgagcttgg cgacattcga 12900 cttcttgtag ccaggatcgc cgaaatgttc gtgaaccgca gcttccttca ccacaaccag 12960 agacgttccg gcagaagata ccagctccat acgcttcctg gtgatggact gaaggcgata 13020 gctgatttcc tgggtcgcgg ccagtttgaa ttgcgcggca acctttacgt tgaaacgttc 13080 gtacccttga gccttctgat actcccgaca tagacgatca atggcctcga ccagggagtt 13140 gaacatattc accgccagct caacgtccga cttgtagcct ttgaagcgta cggcatgacc 13200 ccagcgcttg gtagtgcttc cgtcgcgggc gcttctggat gccttagccg atgctctgtg 13260 gttgttgatg ccaccggcga aatccatgat gcagtcattg tacgtcgcca cggccactga 13320 gaaaaacttc atccagttcg ggattgcgga atagtaacga gtggcaattt gctcatcgaa 13380 ctcttcgcga atctcgccgg tagcttcgaa gtcgtgaagg tcatatttgt ccttcaactt 13440 cttcacacgc tcggctgcga tggccgcttc gtgcggactg gaagagtcgg ctgccatggc 13500 ggtcagtttg cggatgcggt ctttcgcctt ctcgatggct tccggagtga attcgttctg 13560 gtcggtcatg gtcggttcct tttgtctgaa gggtttcgcg tttcaatgga gctattctgc 13620 cttcactcag aatggaagta aagcactttc ttccactatt tcggcatcga ctggaagaaa 13680 ttccagatcc aatcacctgc taccagcaag aggatgaggg cggcaaagaa caggacgacg 13740 gccgcgagct gtgcgccagg cttcagcttg ggatggctga gctttggttc tgcgggaacg 13800 gattgagtgc tggcgctgcg accgtcttct cccaggccgt agccgatgcc gcattcacgc 13860 gcctggagcg gcaccaggga tttcagatac tcggtctgct tttgcgactc ttcgtagatg 13920 ccggcgacgg cgaaccagag ggcgaacacg acggacgtac acacaaccca ggcgccggtc 13980 agcaggaggg ccagcgggcc gatgacgaag acggtagcag ccaggacgat tgcgccgccc 14040 cagatgatga agccggccag accattagtg atgtcgacac agaacttttt cattttcaga 14100 ttccttcggt tacgggatgg aggggatttg aaactctgcg ccgccgagaa catcaatgac 14160 gacctcccag agcgtcggaa cagaccactg gtaacggtcg aagtcggttt caggatcgac 14220 gcccagcgtc acataggaag tggcaggcca tttatgaaca ctgcctttcc gcatgagagt 14280 cgccacgcgg ccgtcaccga gcggattcgt cctgtgcgga acgtacgcag acatcgaata 14340 ttgctgcccg gcgtcgacaa caaatctttg cctctggcgc agacatacag agcccacagg 14400 attccagccg cgaccgccgc aagcctggcg agccgaagaa tgctcataac cttcgtgagt 14460 catttcgccg aggcaagccg agcgatcctc gtaatagttg atgttctcca tcgatccaac 14520 cagcaccaga gactcgaaat cgaatcgatg atcgtggatg gccgagtgat tgaagcaaag 14580 ccgacgcggc agctccgggt gccaaacatg gaggcgaccg gccggaagtt ggacctgaat 14640 gaaccccagg ccgtgcagag tgatcttgtc cttcatcggg tcatggacgg tgctcatgga 14700 taatcctcag tagcagaaat gtattgtgag agttacgatt gacaagccgg tcgcccatag 14760 aagggcgaac caggccatgg ctttgattgt cgtgtagatc atccgaaga ttttccggca cagatcgggc caatgcccat ttcgatggat gcgtggttgg tcaactcgcg accgcagcag 14940. gagcactgac cagtcttccg accgtaggcg actgccgatt ccatcggctt ttcgaacatc ttcagaacgt cgtcgtgctc agtatcggtg cagtcgcgac tcttgatgaa tttgccattt gtgatccggc cgaggtagt gtcgcccagg acgtacaggc taccggcgtt ccggctgtga 15060 gcgctagcct ctttcacgac aacgatgagc ggctcctcgc cttcgccagc taggcggatt ttcgggcgct tgataccaga ctctttcgcc ttctcaaacg ttttctcgat gccggaaatg tccagagtcg gcgcagcagc ttcctgcgcg gccactttct cgcgatactt ggcgaggttt 15240 tcgatggcgc gcttcgcagc agcgatctga ttttctgtca agcgagccgta tttatacaac gactcctgaa ggctctgagc gaagctgaag gaatttccag tccaccactc gatgatatcc gggtgcgcgg cttcgaaagc cttaattttg aggtcgcgtt cttgcgcagc gctacagatt ttctcggcgc gcttttctgc cgccttggca cggctcttgg cgcgctgctc cgggctggtt 15480 ttgtactctt tgtatccgac accgccgcag gcaaagcagg cgcgaccata agatgaaggg 15540 ccacggtaca ggccggtgcc tgcgcatttg gtgcacttgt cgcgatacag cttcacttcc 15600 ttccgggagt tcgggcgggc gcccatggac acatcttcca gcgtcttcgg cgcttcgtca 15660 gtgatcgcta cggtagcgaa gtcatcgccc aggtcttcga agcctgtgaa cagattctct 15720 gctgcgttca tatcgattct cctgtttgga aagttcgttt cgatgagttg actatacgcc 15780 agaaatggaa aaacggtagc gatttctcac taccgttcgt cgggtcgaag acaatcaata 15840 aatgtcgcta ttgatctcga acccatgctc agcgccgtcg ttgtagtcgt actcagcata 15900 gctgtcgcag tagtcgttca aatgctgaat gatgcctaga acatcgttcg cggccttgtg 15960 ccgtttcgcg gcgatggtct tggcgatgct gtcgccgact tccagggttt cggccgtccg 16020 gcgatggatc agcagacggc tccaaagata gagccggacg cgacgaatga tgtctcgatg 16080 gcgctccagt cgtccgtgca actcttcaat ttcttgctcg cgagatttca ctactcgtcg 16140 aagctgctga acttccagtt ccaaatcggc cttagtagcc atgttcacct caaaaagga aatcgtctgg gactccagga agttcgacga ttattgttga gcctgatcga tccagaatgc atccgaccga gccggccctg tggggatagg gtctacacga actataacag gtgacttccc tgactattcg ccaggtcgat cctccacacc atctgcaaat tggcggggcgc ttcgacttca gttttcgttc gtccaggacg gcgcgtctgt cgcaggaag gcagcgtgcc ttaaccgacg 16440 taaccatggg tatagtcgat cattcggatg agctcatcat cctctgattc tctcgacttc agaccgccca aagagtccga ctggccgtcg catttcgcat cgatatccat cgaagacagg aatcctgccg atactgcggt gatatcaact ttgtcgccgg ctttcttgaa gccttcgcac tcagcatcga gggccacaat tgcactcgcg gccatgttca catgactgat gaggtcgggg aagatcacag gaacttcacg cgacatgcca cggaccgtca gcttcaggac tacatacttc atactcacta tcccttttgt atgtgagga agaacttgct gttttccgga tggtgaaaac gctcggtcgc aggcggtctt tcttccggac attgaatcgt cgaaggcggg aaaaccgcgc 16860 cggcgataat cgccgcgagg agtgcagcgg atgtcgacat ccagagggcg gtttccaggc 16920 tcacccgaac ttccggacgg cgcggcttca ttcgctccac cctcttcccg gttcatagga 16980 tggtagactg ccgccgcgaa cccagttgtc ccacatatgg ttcagaccag tcggtggctg 17040 gggtggcgga ctgtagaatc cgggagtctc agtgctgctc aggaaataag gcgtgcaaac 17100 ggcctggacg accaattggt gccgctccca catcttatca atcgctctta gcatgacgtc 17160 ttcgcactga gccttactgt cgaaccgtct gctagtatgg tccggcatct ggacgcagcc 17220 gtctccagtg caaaggaaag cagtagcaat ccatacggtg atactcgcca tttcgtcacc 17280 ctctttagtt gatgagcaga gtctattcca tctgctcgcc aggagtaaag cgcttttcgt 17340 cgggataaat gccgatgatg tctgcgtcga gcatccaaat ctccacggac ggatcgtcgc 17400 tgctgatgtg gtacaggttg tacagctccc gtccgccgac agcgcgctcg cctcgcggct 17460 caaccgccag aaccttgccg tgcccttctc cgtgctcgtc caggtatatg acgtgatcgc 17520 cgacttcata gctttctttc gtgacgaggc gtgaacgcga gctgttctgc gattccacca 17580 cccaggaatc cagcacgccg cctttcatgt cgcgaaacaa tcttgccgat ttgtcgcaat 17640 cgaatacgcc cagaacttct ccgtctttca acacgatatg tacgattggc aaaagagtat 17700 tcatgtttaa tctccattgg ttgataatta gagtctaatc tgccgaaaag ttcccgtaaa 17760 gaattatttt ctcacaactg attagttgca actgttaatc tgatgtatat gtttgaatct 17820 cttttgaacg tttgatgttt cccctataat aagcgcacac agccaacaac cacgtggaac 17880 tacaatgttt aaactttcct ggatattcgg gcgcaaaaag gataatgctg cctgttctga 17940 atcggcgccg gagaaagtcg cacaaatccc tcaacacgat ccgctcgacc ccatgatcaa 18000 gctgggaagg attcgcggct ggaacgtcga gccggagaaa gccccggtca ttcgtagtgt 18060 gaaagatttc ctggagccgg gcctatctgt cgcaatggat agtgcgtatg gtgatggacc 18120 aaccccggcc gcgaaggctg ctgcgggcgg ccagaatccc tatgtcgtcc cgactatgtt 18180 gcaggactgg tacaattccc aagggttcat cggataccaa gcttgcgcaa tcatttccca acactggttg gtggacaaag cttgttccat gtctggggaa gacgcagcac ggaacggatg ggaactcaaa tcggacggca ggaagctatc cgatgaaca agcgcgctga tcgcccggcg cgacatggag tttcgcgtca aagacaacct cgtcgaactc aacagattca agaacgtttt cggcgttcgc atcgcgctgt tcgttgtgga gtctgatgac ccggactact acgaaaaacc 18480 gttcaatccg gatggatca cgcccggctc ctacaaggga atctcccaga tcgatccata ctgggcgatg ccgcagctca ctgctggctc gacggcagat ccgtcttccg aacatttcta 18600 tgagccggat ttctggatta tcagcggtaa aaaatatcat cgcagccatc tagtagtcgt tcgcggaccg cagccgccag acatcctgaa gcctacatac atcttcggcg gcatcccgct cacccagaga atctatgagc gcgtgtatgc ggcggaacgg acggcgaacg aagccccgct 18780. gcttgccatg tcgaagcgaa ccagcaccat tcacgttgac gtggaaaagg ccatcgcgaa tgaagatgct ttcaacgctc gcctggcgtt ctggattgcc aatcgcgata accacggcgt gaaagtcttg ggtactgatg aaagcatgga gcagttcgac acgaaccttg ccgacttcga 18960 cagcatcatt atgaaccaat atcagctggt cgctgccatc gccaagaccc cagctacgaa 19020 gctcctcggc acttctccaa aaggattcaa tgccactggt gagcacgaaa cgatttctta 19080 tcacgaagaa ctggagtcca ttcaagagca catattcgac ccacttcttg aacgccacta 19140 tttgcttctg gcgaagtcgg aagaaatcga tgtgcagctg gaaatcgtct ggaaccctgt 19200 ggactccaca tccagccagc aacaagcaga attgaacaac aagaaagccg cgaccgatga 19260 aatctacatc aactctggcg tcgtgtctcc ggatgaagtg cgcgagcgtc tgcgtgacga 19320 tccgcgttcc ggctacaacc gactcaccga cgatcaggcc gaaaccgaac cgggcatgtc 19380 tccggaaaac ctggccgaat tcgagaaggc cggtgcacag tcggccaagg cgaaaggcga 19440 agccgagcga gccgaagccc aggcgggcgc cgtagagggc gcaggcggcc cggttcccgc 19500 cgctccacgc gggactaagc ctctcgcgaa agcggccgag gaaggggcca gcgaggccgc 19560 tgaaccgccg tcgaggccgg accccaaggc cgagctgcgg aacttgttgg tcgatctttt 19620 gtcgaagctc caagacctgg acgacattaa ggcgccggac ggcgtagaca tagagcacaa 19680 tgatgcgcct ggcttaaagc gcacatccaa acctggcgtg tctggtatgg agccttcggt 19740 gttttcgtcc aaccgcatcg tcgggcctcg tgatcattcg gaactccaga gaatcaaggt 19800 gaatggaata accaccctga tcgaaaatcc gcgcggaagc attcgacaag gcaaggatgg 19860 gagttggcga gttcagatga aacaccacta cgggttcatc aagggaacga aaggcgctga 19920 tggggatgaa gtcgattgct tcgtcggtcc gaatctggga tccaaacggg tcttcgtcgt 19980 caaccaggtg aacaaggaag gtcagtttga cgagcacaag tgcatgctcg gcttcaacaa 20040 catcaacgat gcgaagtctg gatatctgtc ctgcttccgc ccaggttggg atggtctcgg 20100 ctccatacat gaagttgacc tacccgcgtt ccgtcgctgg ctggcgaacg gcgacacaac 20160 caaaccgttc gggggcgagt gatggcattc aaggcctcca aaaagcgcga acgccgggcg 20220 cctcttccag tcggaagagg gaagcccata attccatcgg caggaatcga ggcctggtat 20280 cgaaagcaga tgaaggatat gtccaagctc atgatcgccg actatcgaag cgagattgag 20340 aatgcactgt cccagcctgc ggccgaacgg ttcttcgcca gcgacgaatc cgttaacgtt 20400 ctgttcaaga tgacccttcg aagcctacag cagcgatgga gccgcatttt tgaaggcttc 20460 gcggccaaga tcgccccgga gtttgttaac cggaccgaag aagcggccac cgccgcgacc 20520 ctgcacagct tgtctgtggc cggcgtcgat cagccaagag ctgcgtacaa tgagagcgtc 20580 aggaataccc tggaggcagc aactacttac aaccatactc tcatcaccag gattcaagag 20640 gaagtccacg agaagattta cacatcagta atgttgtctc tgacttcccc aaatccggaa 20700 gagcaaggaa cttccggcat aacgaacgca cttcgcaaag tcgggaagtt ctctgaagat 20760 cgaatcgaac tcatcgcaag agatcaaacc agcaagcttt acagttctct gagcgatgag 20820 agaatggcgg aaaatggagt cgaggaattc gagtggatgc actcttctgc cggcaagact 20880 cctcgccata cccacctgga gaaagatggg aaaaggttca agctgaatga ccccagactt 20940 tgggagggtc cgaaggccga ccaggggccg ccaggatggg cgattaactg taggtgcaga 21000 aagataccaa tcatttgata tcgataggag cgctatatgc cgttagttca tggcacttcc 21060 aatgaggctc gttctgaaaa catcaagcgg gagatcgaag ccggtaaaga cccaaagcag 21120 gctgcggcca tcgcttactc catccagcgc agtgagaaag ggaagacggc gaaagattgt 21180 tcgcctgagc tcgttgccga tcttcgcgcc ctggtggaca ctctgtcgag gctcgtgaaa 21240 tgaaccgcaa gacatgccgg cgccgactcg tggtcgatgt aatcagggcc aatattcacg 21300 gcggattctt cagcctgaag tttgccgcca tcgatttggc aatcatcggc gtcgccatct 21360 tgatgacttt tggccgataa tgctgagaaa atctggattc tgactaaaaa ttctagtccg 21420 gatagccgca agttaccgtt tacggaaaat agcagtaatt tggaaagcct actgccgcga 21480 ggctttaaca gagccagttc ctaatttccg atttagccgc gtgcttcaaa agtatatagc 21540 ctgggaaatt agaagtaacg ttccaataga attcatctat aagtaacgtt ataataac 21600 gtcaatctat atgctctaga cgtattgaaa ttcaattttt aattggtaaa ttggtaattt 21660 ggattagttt total agtctcgcgg cagtaggctt agcaaatcc cgtaaagttt ccgagacca attack tttcgcggct gaggaactg gtaattagat cataataca atttaatgt aagttaacag tcgcggctac atctaattat tgttccgctt atttaccctt agatgtactg cgtatataat acagccatag tccacgactc ttcgattaa cgatgacaaa gtcgaaaaga aaaattgacg aaaatggata tatgaccatc gagggctgcc cgatcagctc ttatggcgtt ttccagtatt ctgctggtca actcggtctt ccggggcgatc cgacggcggat tgtcaacgta tatcgcccgg agtctgccgt cagcgatcct gagtacatcg aatctctgaa gaatctcccg ttgatcgacg agcacgaat gctgtcggga ttcgacgacg atgacgacag cgtggcccc gggtggaggg catcatcacc tccaacgctt actacgaagc cccatgggct cgcggcgata tccgcatcta ttcccgcaac atgcagaatc agctggaag gggcaaagaa gacctgtccc tagctatag ttgccgctac actgagcaac ccggcatctg gaacgggacg ccttatgaag tcgtccagga cagatgcgc ggcaccaca tcgccctggt 22380 aaagagggt cgtgtgccgg gggccagagt attggatgt ctgtgttttg accatctcag 22440 ttttgatttc agaccatccg atgagggtaa tgaatgagt ctcaagaag ccaagcggaa 22500 gccccctgtc cagcgcgtag ggcaagctgc tgactcggcg gtcgaaggt tgcgcaccct 22560 gtggccgaaa ctctctgcgt ctgtccagaa gttcctgggc gagaagagc aggagccgga 22620 gcatcaggaa ggtgccgctc cggccgaacc gaccgacagc gagcacctga ccgagcatcc 22680 gactctggaa ggcgcccaga aggacgacga agagcaggaa gaggagcctt ccgttgtcga 22740 tccggccgtg gccgccgtcg agccggagca tcaagaagc gccgcatccg aaatgtccgg 22800 tgaggcgaa gtcgccgac tgatctca gtcaaagcc attctggctc gactggaggg 22860 aacggtagcc gaggggcag acgagagca tggcgaggt caatgtcg tcgaggtttt 22920 ggaggagcag agcagcctca gcggctcgca aaccgccacc gacgatggtg gtgagagcaa 22980 ggataacagc gaggaacttc ctgaaatggc acagagaac gcgcaatg ctgcaattcg 23040 cggtctctat cgcgacattg ctgctaaaga tcgcctctac aagcgtctta gctccgtggt 23100 tggtgcgttc gatcaccgag ctatggactc ggctgaagtc gctgtttacg gcgtgaaaaa 23160 gctgaacatc agctgtgcga agggccagga agctctggcg ctcgacatgt acctgaaagg 23220 cgtcgaagcc tcgcgcggcg cggccagccg tcaatcgaaa gcccaggatt cggccggttc 23280 tgctccgcag tgcgccgagc tggacagcta cctgaagggg gagtaactca tgttccagaa 23340 acaagtttac cgccagtaca ctcctggttt tccgggcgat ctgatcgagg acggcccgaa 23400 gcgggcgcgg ccgggtcgaa tcatgcctct gtctgccgta aatccggctg ccaccgccac 23460 cggccccaac cgcatcagtc gcgctttcgg ttacgccggt gacgtcagcg ccctcggcga 23520 aggtcagccg aagaccatcg cggctcgcgc ttctgaagtc gtgatcggcg gcgccaactt 23580 ctttggtgtc ctcggtcatc cgaagcacta tgcgctgttc ggttcggccg gagactccct 23640 ggctcccagc tatgatctgc ccgatggcgc cgaaggcgag ttcttcgaca tggccaccgg 23700 cctggtcgtc gaaattttca acggcgccgc aaccgccctg gacctggact atggtgacct 23760 ggtcgcctat gtaccaaaca acctgcctac cgccgacaac gcgcttggcc tgccggccgg 23820 cgccctggtt ggcttcaagg ctggctccat gccgaccggc ttggtccaga ttcccaacgc 23880 acgcatcgtt aacgccatca gtctgccggc ccagtcggcg gggaatctgg tcgctggcgt 23940 taccatcgtc cagctcacgc agtaaggagg cgtcatgagc cagatcagca agacccattc 24000 gcgcctcgca ggccgcaatg cgaaaccttt cgacctgaaa aacatcacca atgacgccgt 24060 ggcgtctctg cgccgcatcg gcctggtatt cgatcacgcc gtcgtccagg accagatcaa 24120 ggccttggcg aaggccggcg cgttccgctc cggctcggcc atggacagca acttcaccgc 24180 cccggtgacc acgccgtcca tcccgactcc catccagttc ctgcagacct ggctgccggg 24240 cttcgtgaag gtcatgaccg ctgcacggaa gatcgacgaa atcatcggca tcgataccgt 24300 tggctcctgg gaagatcaag aaatcgtcca gggcatcgtg gagccggccg gcactgcggt 24360 ggaatacggc gaccacacca acatcccgct gaccagctgg aacgccaact tcgaacgtcg 24420 caccatcgtt cgtggcgagc tgggtatgat ggtgggcacc ctggaagagg gtcgtgcctc 24480 ggccatccgg ctgaacagcg ccgaaaccaa acgccaacag gcggccatcg gtctggaaat 24540 cttccgcaac gccatcggct tttatggctg gcagagcggc ctgggcaacc gcacctatgg 24600 tttcctgaac gatcccaacc tgccgccgtt ccagaccccg ccgagccagg gctggtccac 24660 tgccgactgg gcaggcatca tcggcgatat ccgcgaggcc gttcgccagc tgcgtattca 24720 gagtcaagat cagatcgatc cgaaggcgga aaagatcacc ctggccctgg ccaccagcaa 24780 ggtggactac ctgtcggtca ccacgccata cggcatttcg gtttctgact ggatcgaaca 24840 gacctatccg aaaatgcgga tcgtgtctgc tccggaactg tcaggcgtcc agatgaaagc 24900 ccaagagccg gaagatgctc tggtgctctt cgtcgaagac gtgaacgcgg ccgtcgatgg 24960 aagcaccgat ggcggcagcg tgttcagcca gctggtacag agcaagttca tcaccctggg 25020 tgtcgaaaag cgggcgaagt cgtatgtgga agacttctcc aacggcaccg ccggtgcgct 25080 gtgtaagcgt ccgtgggccg tggtgcgcta cctcggcatc taaccgatgc ctattcacca 25140 aaggccgggt ttccggcctt tgttcactct gactctgact cggttgtagg ggccggttag 25200 ggcataatta ctaggactac gccaatgact gtttacatcg tttccgccat gactcaatcc 25260 gtgtcttaca atgcgtatga cacctctgat ccgtccaatc ctcgcctcca gcgaaagatt 25320 ctgattcgtg gccgcgccgg catcgcatcc gaaacttccg gcttcggcga catgatttcc 25380 gacgcggccg ggcgtccgat ctggaccccg cagggcgatt gcactgccgt gagcgattcg 25440 gatttcgagc tgcttcaggc caataagatt ttcatgcgtc acatggagaa gggttatctg 25500 cgagtcgtga agaccgacat caccagtgac caccagcgga tttccaaaga gactcgcacc 25560 atggagcgtg atggattcca gcctctggac gctactcgcc tgcagcagaa aatcaaggtg 25620 accacagcca gcgcttccca ggaacaagag ttccggattt aaccgagggt ttcggtatgg 25680 tgattttcga cgaaaataag tttcgcacgc tgtttccgga gtttgctgat ccagccgctt 25740 atccggacgt gcgcctgcag atgtatttcg acattgcgtg cgaattcatt tctgatcgcg 25800 attcgccata ccggattctc aacggcaaag ccctggaagc atgcctgtat cttctgaccg 25860 cccacctcct gtcgctgtcc acgatgcaag ttcagggcgc ggctggaggt ggcgtcacag 25920 caggtgggac tcaaggcggt ttcatcacca gcgctactgt cggcgaggtt agcgtggcta 25980 agctcgcgcc cccggccaag aatggttggc agtggtggct gtccgggacg ccttatggcc 26040 aagagctgtg ggcgctcctc agcgtcaagt ctgtgggggg attctacatc ggcggccttc 26100 cagagcgtcg aggattccgg aaggttggag ggacgttctg gtgatccctg gagcgaatct 26160 cctgcgcatg gccttcgggg tcattggcac tcaaattgtg agatatcgca agtttgagca 26220 gcgagtgaag aatgatcaag cccagtacgt atccatgttc ggggagcctt tcgacctggc 26280 agcgtctgtc cagcgagtcc gacgcgatca gtatgtccag tttaatctgg agttccaacg 26340 gaattatgtt atgatcttcg ccaactttga gatggttgac ttggatcgcg atgtggccgg 26400 tgaccagttc ctctggaccg gaagagtttt tcagctggag tctcaaggct cctggtttta 26460 tcaagacggc tggggagttt gcctggccgt ggatatcggt gctgccaagc tcactgatga 26520 cgggaaaccg actttctagg tgatgtatgt ttgacggcga actgatagcg aaaatggttg 26580 tcgagctgaa tgcggcgatg acatctgctc aagaggcttt gcagttcccg gattttgaag 26640 tagtccagaa agctcagccg acccaacagg gaacgtcaac caggccgacc atctttttcc 26700 agaaactgtt tgacattcct cgcgggctggc ctgccaccga ttggcacctg gaacacgg 26760 ctcgcaaata tgtagaaata actcgacagc atgtagagac gactttccag attagttccc 26820 ttcattggca gaatcctgaa ataactcacg tggttacggc ttccgatatc gccaactatg 26880 tgagggctta tttccaagct cgatccacga ttgagcgcgt aaaggaactg gacttctcca 26940 ttcttcgcgt gtctcaaatt tccaacgaag cattcgagaa cgacaatcac cagttcgaat 27000 tccacccaag ttttgacatg gttgtaactt aaaccaata tattcgcctg tacgaaaacg 27060 cagcatattc ggccgatggg gtattaatag gcatatgagt ctgaggcgcg attcagagct 27120 aatcgccgcg cacctccaga tgttaagagc catgcgcggc aggtccgttt cagccggatg 27180 gtattccacg gctcgatatc ctgacaaggc aggcgggtcg gtcggaatac aagtcgcgag 27240. aatcgcacgt ctcaatgagt acggcggac tatcgaccat ccggggcggga ccaggtatat tagggacgcc attgttcggg gccggtttgt tggcgttcgg ttcgtcagaa acgactttcc 27360 gggagaacc gaggtaacta agcctcacag aattaccatc ccggctagac cgtttatgcg atatgcttgg aacttgtttt ccgcagatcg cgccgcaatc cagaaccgga tagccatgag gctggccaga ggacagatca ctccagatca agctcttgcc cagatcggcc tggcgttgga aggatacata gccagaagca tcaggaccgg gccatgggtg gctaactcag catctacggt caggagaaag ggattcaaca gaccgctggt cgatacggcg cacatgcttc aatcgattag cagcagagta acataaccag cagatcatcc agtgatcagt cagagccgtt atatccggat catttcgggc gtaggcgcag gcgctccggt cgcaggccga aagctgattc tgcgcgtcat 27780 gactaccaac aacgtcatcc cgcccggat cgtcatcgag ttcgacaacg ccaacgcagt catgtcatac ttcggcgcgc agtcggaaga gtatcagcgg gctgcggctt atttcaaatt 27900 catcagtaaa agcgtgaatt cgccgtccag catcagcttc gctcgctggg taaacaccgc 27960 catcgcgccg atggttgttg gtgacaatct gccgaagacc atcgccgatt tcgccggctt 28020 ctcagcagg gttctgacca tcatggtcgg cgcggccgaa cagaacatca ccgccatcga 28080 tacgtccgca gcgacttcta tggacaacgt ggcgtcgatc atccagaccg aaatccgcaa 28140 gaacgccgac ccgcagctgg cccaggctac cgttacctgg aatcagaaca ccaaccagtt 28200 caccttggtc ggcgccacca tcggcaccgg cgtcctggct gtggcgaaat ctgccgatcc 28260 ccaggacatg tccactgccc tcggctggtc cacctccaac gtcgtcaacg tcgccggcca 28320 ggctgccgat cttcccgacg cggccgttgc caagagcacc aatgtcagca acaacttcgg 28380 ttcgttcctg ttcgccggtg cgccgctcga caatgaccag atcaaggccg tgtcggcctg 28440 gaacgcggct cagaacaacc agttcatcta cacggtcgca acttccctgg cgaacctcgg 28500 cactcttttc accttggtga atggaaacgc cgggaccgcc ctgaacgtgc tgtcggcgac 28560 tgctgccaac gacttcgtgg agcagtgccc cagcgagatt ctggccgcca ccaactacga 28620 tgagccgggc gcttcgcaaa actacatgta ctaccaattc cctggccgca acatcaccgt 28680 ttccgacgat accgttgcga acaccgtcga caagagccgg ggcaactaca tcgggggtcac 28740 ccaggccaat ggccagcaac tcgcgttcta ccagcgcggc attctgtgcg gcggtccgac 28800 cgatgctgtg gacatgaacg tctatgccaa cgaaatctgg ctgaagtcgg ctatcgctca 28860 agcgctcctg gacttgttcc tgaacgtcaa tgcggttccg gcgagcagca ctggcgaggc 28920 gatgaccctg gcggtgctgc agccggttct ggacaaggcg accgccaacg gcacgttcac 28980 ctacggcaag gaatcagcg ccgtccagca gcagtacatc acccaagtca ccggtgatcg 29040 ccgcgcctgg cgtcaagtcc aaaccctggg ttactggatc aacatcacct tctccagcta 29100 taccaacagc aacacaggct tgaccgagtg gaaggccaac tacacgctga tctattcgaa 29160 gggcgatgcc atccgcttcg tcgaaggatc ggatgtgatg atctaatggt ttgcggcgga 29220 ctcgatccgc cgcgaccttc cataaatgga gtgaggaata agcaatgatc aacatttctg 29280 cgttcggctc gatctgccag ttcacggcaa gcagaacttt cccgaacgga ttcaccgtca 29340 ccgagtttgc cgacgatgcc gatcccatcg acagcccgcc gttcaccgct gccgataccg 29400 gcgtcggtct caacggtgac atggtagttt ggaaccgggc gaacatcctg gaagtagtcg 29460 tcaacgtcat tccgaatacc gagggcgagc gcaacctggc agtcctgctg gatgccaacc 29520 gcaccggaaa ggacaagtcg ggcgctcgtg atgtcgtcgg tctggtcgtg gcgatgccgg 29580 acggcagcaa aatcacctgc accaacggca cccccatcga cggcgttctg atcaacgcgg 29640 tggcaagcgt cggccgtctg aagaccaagc cgtatcggtt ccgatttgaa aaagtgatca 29700 aagccggtac tagctgatga agaaaattcc gctgacagca gtccccaatc aagcgatctc 29760 atttaacgcc ggcagcagct attggaagat tcgcctgtac cagaacatgg acatgatgaa 29820 tgccgatatc agccgcgacg gcgtgatcgt ttgccatggg gtccgctgct tcggcgggat 29880 tcctcttctc cagtacagcc atcagtaccg acctgactat ggcaatttcg tcttcgaccg 29940 cgacgccgat tggacgttgt tcggcgacgg aatcaacctg ttctatctgg acggcgccga 30000 attcgccgag tatcaggcgc ttgccacgag gaaagaatga gcacatcaac gatcagaacc 30060 gggacgaaca acgatatcct tttggacgac aatggaaaca tggttatcct cagggatgtc 30120 gaagcgtgcg cccaggacgt tcgggcggcg atgctcatgc gcaccggcga aaacattttc 30180 gatgtgaact ccggcgtggg atatttcgaa tacatcttct cgccgcagaa aagctatgat 30240 gacgctcgca aatccatcgc ggatgcaatt ttatcctcgc cggatgtgac cggcatcgag 30300 cagcttgaca tcgacataac cggggaagtc ttcggcgtcg atgcgaaagt catcaccatc 30360 cacgggcctg ttaccacagg agtttgaaat gagtaccatc cgcatccaat acgccaacgg 30420 cacccaactg ttcctggacg gcaaaaatcc gccgcccctg gacccgctgc cctcgtttaa 30480 cccgtctgtc gaagatctgg aaggcctgga ccgcgaaaag aacatcgaca agggcgactc 30540 ctcgccggcc ggtcttcccg ttcccccggt aaacgtcgat tccaatgtcg acaacggcgg 30600 aaccatcccg gctccggtat cgaccgacgc tgctgcggcc gaatcggccc cggaaggcgc 30660 ccaggaagct cctgcagcag gccaaggcga cgagaaaggc gccgaggaag ccccgactac 30720 agcccctgta gaaaaggccg aggaaacggc ctcgccggcc gctgaagagg aaaccccggc 30780 tcccgccaag gccacctctc gcaaaaccac cagcaagtaa ggactcgaca tgatcaacgt 30840 cagcggcttc ggcacaggaa ttgtaatagt ttccgcctca tcgttcccga tggggttttc 30900 cttgtcgaag ttcgctgatg atgagagtcc gatatcctcc aaagagctgg agccgttcgg 30960 atatgagatg ctttatgacg gcggcctatt cgcctttgac aaggctgctc ctctggaagt 31020 atctgtatcc gtcatcgcag ggagcgagga tgatattaac cttcgcaccc ttctcaattc 31080 caaaaaggga tcattcagat ttcttccggg cagcatcccg gatatgacga ctctcgtggc 31140 cactcttcct gatggcggcc gcaccgttct gtccaatggg actatcatca agggtccggc 31200 catcgacacc atacagaaca ccggacgacg caaaggcaac acgtacactt ttgttttcgg 31260 tagctatctt ggcgcccaga ctgcgcgtca agccatttct aacgttatcc aatcggtact 31320 ggaggtggtc tgatgttggg gattttcacc agcctcctaa gttcgcgatc tttttcgatt 31380 gtggaccaaa acacaaacca gctagttgct gcggatttga ggataagccg ggtcaacacc 31440 cggttttctt ctgtagggca acgccacatg ctggaagaatg gtacgaccaa gatggattcc 31500 agaacgatcc accctatgga aatcatcgtc gaagtatttt gcccttcaat tgatgtcgtc 31560 gatcagatca atcaattgct cctggatcgc gacacactgt acaaagtcat cactcgcggc 31620 atggtattcg aacggatgat gtgtaccagc gaagcgctca atcagactcc ggatatgata 31680 tcggcgactc ctgcgcggct gacattctcc caagttctcg tccagaatcc caagcctata 31740 atgttcagaa atgcagggga ctcttctatg atcgaccgag ggctggccct agctgaagac 31800 gtggttggct cggccggcga tctgttcgac tacgcagtaa acggcgtcca gaacgccgca 31860 gacttgttct gaggtgccaa ttgaactctt tcctcaagtc tattctcaac acgcctactc 31920 tcaccatacg cgatgatgtt accaaacttc ctgtctggaa gagtcttcaa gtcaagaaag 31980 tggaaattta ctcgccggct tccgtagtgt cgaaacctct ggcgacgaaa gaccagacgg 32040 aagctcaagt gtacaccgaa gctctggaca ttgatgtgaa gaatggaaag atcatccaac 32100 cggtgcgact ccgcatcagt gctatctgtc cggacctgtc caccgttgaa agtatcatga 32160 acgctttcaa tgataacacc tcgactttcg ctatcacttc taagtcgata ttggccgata 32220 aaatggccat catgacgctc gatgtagatc agtctccaga catgttgaac gcggctgaga 32280 tcaatatgga attcgagcag gttgagcctc cagtattgaa taaattcgat cctgcgttcc 32340 ctcaagatag tccgacttat ggggtacaga ttcaatctct ttctgatgct aatttgctgg 32400 atttgggcgc catcggcgat tcgatatctt cggccgcaaa atcgctatat aatcgcgtga 32460 ccagctactt ctgaggatgt atcatgcttg aaatcaatct tcccgatggc cgtcaaattc 32520 gcgtacaaat cgaggcgtgg tcggcattgg atggctggga actccagcgc cgtttcgtcg 32580 aattcgctgt cagccaagat tccgacttcc gccgctcttt caccatggaa atcctgggct 32640 atgcgaaagt gctgcttggc gacgatgaca ccggcattcc gctgaccacc gcggcagtca 32700 tcaacaacca cctcggccac tggaagaacg tggaactggt tttcaactct gttctcaagc 32760 acaatggcat cgacccggcc acgcacgccg accggccgga ctattgggaa caagtcggat 32820 cgcagatggc catcgcattt ctggccgagg cgtccaagct cattggtcca gcaatgaaga 32880 tcgccgaagg actcgccaac aagccggagt gattcatgtc tagtgatttg gatgaattca 32940 tacttcggta tgaggccgat actgccagag ccgagcgcaa tctggagcgc ctccagaacc 33000 agatcaggcg cgtgaacagc gcatcgacga gtggccttca ggatttgcgc cacttcgcag 33060 acggcgcggc cactgaactc ggccgagtcg ttccgcagat cgattctgtg acgagcgcga 33120 ttcgcgggat gaacgcgcaa ctggcgatag gcgccactgg cgtggccctg gtcgcggccg 33180 gcgtcaaggc gttcatgaac accagggacc agtacaatca gcagcgcatc caggcgatgg 33240 acatcggcat cgccccggca cgcttggaag agtaccagag aaaattcgtt cgccagtccg 33300 gtggaaccat cagccgcgag cagggcgcgg agatgaccaa aaatctggca gacactttcc 33360 ggcgtgctta tcgcgatatc gggcgagtcg gcccggaagc gcgaattctg cgtatggccg 33420 gcgttgatgt cgggagcttc caaaagggca tgcggccgct caacgacatc attactgatc 33480 tggccacgaa aatggccaag ctgaagccgg acgaaatttc tgcctacgct gatgcccttg 33540 gcgtctcgcg agactacctg agcaccctgg ctaagatcgg cccggccatg ggaaaagtca 33600 ccgagatgac gactgcggaa ctccagtcca gggtccaggg cgagtccaac attcagaaat 33660 tcaacgatgc tctggcgaat ctcaaccaga cgttcaccac cctggaaaac cgagtcggcg 33720 aaaagctcgc gcctgcgttc accaagctga tcgaaatcat cgacaagata gtccaggcta 33780 ttcccaatga agtggaaagc ttcgcgaagg acaccaaatc ccgttgggaa gatggagtgc 33840 tcgggaaggc gaccgttggc agtgatatcc tatccctcct cagccccggc gccctgctcg 33900 gtcgcctggc agcgtggggg actcgtcgcg gcatggaaga atcagggctc atcgacaagg 33960 acaaggttcc cggcgctcaa accagcgaag acctggccaa gaaacaagaa gaccaggaca 34020 aggctactaa gtccatgaaa gagctagaga agctggctga ccagaccacg aagtctacca 34080 atgattttgc ggtggcgatc aacatgttca gtggcgcggt atcgtcgttc gcgaatgccg 34140 ttgacgagcg ccaagcttgg gcagcctggg cggggaaat tggtcgggcg gtcggtatgg 34200 gaagcaccgc gccgacttcg cgggccaccg gcgtctatcc gcacgcgatc tatgatcagt 34260 cgaagagtgg cgcggccgga caggtcttcg gcgagccaat cggcgcccag tctcttcgca 34320 atcgcatgtt ctcgccgcag cgcaaggccg aaccggtcac cgttccatcg tacatcaacg 34380 atatcatcaa agatgcttcg aagatgtaca acattcctga gctggacatc aagaaactca 34440 tatacaccga aagccgattc aacgccaggg ccaccagcga agccggagct aaaggcctca 34500 tgcagctgat gccggaaatc gccaaggcgt atggtatcac tgacgtatat gaccctcgcc 34560 agaacatcct cggcggaacg cgcctactgc gggaaaacct agatcgagca aatggcgaca 34620 tgcggttggc cttgacctac tatcatggcg gactcgatcc gaagaactgg ggtccaagga 34680 ctcgcgcata tccgggtttg gtaatgagcg ctccaatcga gctgatggaa gaggctcagc 34740 gcaagcagaa ggctgcggcc atgaccgtcg ccagcgagac gttcgccccg gaaggcggcg 34800 acatggacat tcgtccctat gatggcgggc gactggaaac cccagaccag ggcaagaagg 34860 aagatgagcg ccgcgaagcc cgtcgatatg acgacagggt tgtgcgaccg gaaattcgca 34920 tcatcgaccg catgccagac cgcagcgacg gcgaaatcct caagatgtct agacgtcaag 34980 aggccgaccg ggcagattct ggattccgga agttcccgaa tcaagttcgc ggcgagacca 35040 agcagaacat ccaggctcaa ctcactgcag gagccatcgc gcaagtgatc ggcgttaacc 35100 ccaaccagat catgcgccgc gaaatcagcc gttctgactt gctgttcgga tacaaccaag 35160 ccatcctggg caagcaacag gagatcaagg ccgccgcgac cgaagccaac aacgtattcc 35220 tgtctccagc caagcttgcc gaagccacgg ccaaggtgaa cgcagcatcg cgagaaatgg 35280 atattctcag gacgtatggc gagcaacttc tgaagagcgc tccagagcgc ggccaggagc 35340 tgaccatcgg tcgaatcgac atgttggtca acgtcaccgg cgcgaattct ccggaagagg 35400 ctcgcgagat attcagtaag cagactgcag accagctgac tacggcaatc caggacgctc 35460 aaaacgattc cgcaactaag atactctact gatgaaaaag agaattctgc gagtaacatt 35520 caacatgcct tatggacccg aagtcatccg cgaagatctg gatgttcggg tccggattat 35580 gaaggctgcg ttgcggattc agaaccgggc gacgatggaa attttcggcc tcaccactca 35640 gcttcgcgag tctcttctgt cgcagttcac cgcgtggaag catcggcaac gtcaagtggg 35700 catggaagat gaattgatga tcaaggtgtc ggtggaagcc ggctactctg accaggggcg 35760 cgagcaagtt tccagagtct ttgtcggcga agtcgccatt gtcgatatca tttctccgcc 35820 accggacatt ggaatccgca tccagtgcta taccaggcaa atcgacagga cgaagaccat 35880 tcggaatatg ccgcccgcca acacgacgtt tgtcaagttc gtcgagtggg gcgcgaacga 35940 aatgggattg aacttcatct gcgataccag ttacaacgat caagttctga agaatccggg 36000 ccggtctatc actgtcgcgt cggcaatcct ggcgtcgatt caggatatgt acatgccgga 36060 cgtggccgcg ttcgtcgatg atgacatatt gatcgtgaag gaccgcgata aagtcattcg 36120 tccggatgag gtgaccaacg tcaactcgtt tgttggaatt ccatcttggt ctgaatgggg 36180 cgtggaattc cagtgcctgt ttgagccatc gattcgtgtg gctggaggcg tagcggtcga 36240 atctctcatg aatccaagtg ttaatggtaa ctatgtaata actgctctgg aatacgattt 36300 ggccagtcgg gatcggccgt tctatatcaa agtcatgggg agtccagcag cataatggcc 36360 agggaaatca aatcattcaa catgttcgga gttcactata cttcgcggca attctgct 36420 gtcgatgggc tcagcatgat gtcggaaatt cagagcgtgc cgccagaaga attgctcaag 36480 ggtactgatg tattggcgca tccggaagac catccggaag gcatctggct tccattgact 36540 gctgcgaaca tcaatcttta tgtcgttgat cgagcgaaag tatagctcc cgtacaagtt 36600 cttgcacttc tgtccgaagt ggtaatcgac tggaattttg gttttctcaa agactggacc 36660 ggagtcaaga ttccatccag atttgtcgaa gatatcaaaa gcgtgaagac ggcacattca 36720 ccttctgtag ttgcgagttt ggtggcgaac ggttcggcct ctatgcgcga gttggaagag 36780 tattattcga ctcaagatgc ctttaagatg atagatatca tgacggcgaa gagcgtgaac 36840 gaggccttgg cgtccgaagc atcgcacaac agaatcaaaa agggataatt cctaaccggg 36900 cctgggaagg ctatactaga cctgccaaat cagaggcttt cccatgtcca atatttctct 36960 aacatccgca aaagctcccg acaggacgcg actgatcgcc gctcttgacg ctcggtcgcg 37020 gcgggatgct ctagatttcg aagtaatgat accggctcag gttgttcaat atgaccgggc 37080 cgagaatatc gcgacgattc aacctctcat cacctgggtt gacacggaac acaacgccgt 37140 ccaaaggcat cagctggttg atattcctgt aatttccatg ggggctggcg gcttccacat 37200 aagtttcccg attcagcaag gtgacatagg ctggatttat gcggccgacc gcgacacatc 37260 tcagttcctg gagtcgttgt caatgtcgaa gccgaacacc ggccgcatcc ataagttcga 37320 gcatggcctg ttcatcccgg acgtattccg tcgatacacc atcaattccg aagattcggc 37380 cgctatggtc atacaatcga cttccggagc gaccagaatt tcgattcgcg gcgataacat 37440 caagataact gcgccgtcga acgttactgt ggatactccg caggcgaact tcaccggcaa 37500 tgtgactatc gctaacaccc tggtcgtaaa cggcatcaac gtgaacaacc acggccacct 37560 cgaaaacaac ccgcctgatg cccggacgaa aggcggcatg gttgcttaag gagattttca 37620 tggcaagttt tgatttttct gatttaacag cggggggggg ttgtaatggc taactacaac 37680 tacatcgtcg atactggtgt gatagtcgca gataccgccg acgttctgag cgacgttgag 37740 gccgagttca gcgccgccct cggtgccaat atcaacttgg ccgcgagcac tccgcaggga 37800 tcgcttgtcg cggccgaggc catcgcccgt tccagtgtca tgcggaatga agcgcgaatt 37860 gccaatacca taaacccgaa cgtttcattc ggaacgttcc tggacgcgat ctgtgccttg 37920 atggggatcg agcgcggttc tgatctgtca accttcggct atggagttca agtcaccggc 37980 cgcagccaaa cccgcatttc caccgggtct agggtccaga ctccggccgg cgcgatcttc 38040 acagtgatga gcgatgtcac gatccctgct ggtggtgtcg cgaccatcga tatcaaatcg 38100 caggagtatg gcaacattcc tctgccggtc gggaatctca tcatcatcga cggaacaatt 38160 ggatggtccg gagcaaaagt catcgcctcc actcgcgtcg atccgggcag ccgccaaatg 38220 agcgatgcag agttgaagaa tgcccgcgtt aatcgattgg ccatccaagg ccgcaactcg 38280 actatggcca tcaagtcgta tgtgagcgcc gttccaaacg tcacgtcggt gaacgtaatc 38340 gagaacaaca ccggcgccgt tcaagtggtg aatggagtct cgtttaccct tccgtatgct 38400 gtttgggtct gcgtcgccgg aaacccggat aaacaagcag tcgccgatgc gttgtgggcc 38460 gcccataacg gcggaactcc atgggactat ggtgcgacga acaacggcgt cccggtggac 38520 ggtccgaatg gcgttcctgt gcgcgatccg gcgtccggtc gaaagtatgt cgtgaagtgg 38580 accactccaa ttatgtacga tggatatgtt aacgtaacag tccagcaagg ttcctcctct 38640 gtagctccgg aagccattca gaacgcagtg gtcaattacg cccaggggaa agtggaaggg 38700 gaagaggggc tggtggtggg cgcgagcctg tcggcattcg aagtcgccgg agccatcgct 38760 cgcgaaattc ccggcatcta catcaaactc tgccaggtcg cgtgcgtcgc ggctggctcg 38820 ccggctccgg ctccgggcga tttcacttcg gaatacgtca tgagcgcatt cggccaggct 38880 accattccg ttggtaacgt tcggtgact tcgtatgac tctgcctgcg tacaattcgg 38940 acatccaaca agctctgaaa tggctccata accaggcgcc tggaatcacc ggcctgatcc 39000 agagaaaggc gcaatggtat gataca gccgccaatt ctggggccaac tgggagcgcg 39060 acgttttcaa cttgagacc gccaacccgt tcggccttat ggttttgtgc atcatcctcg 39120 gcacgccttc gaaagggttc ggcctttatc caagaacag ttctgggca tcggtcggc 39180 tacgccagaa cttcatctat agcggtacac aagtcccgcc accggcagac gcatcgcctg 39240 gaggcaactt ctacggtggc ggcaatgccg aaattctca cttggacgaa atcaggaag 39300 tgcttcagct aagatatgta gcgctgatt cgaacggctc gattgcatat atcaatcgca 39360 tgcttcgtta catattcaat gatgatgagc catgggacga ggcgaccggt ctgtacttct 39420 atctcatgga ctcaccggc gagaatggcc ctgtggagaa cttggcagta tatcggaag 39480 attgggaagg tatggtgctg ttgtccagtt cgcccagaac gaaccacgtg ctgacatcga 39540 cccctgccag cgacgccgat tggccggg tcgatccggc cgcgagcggt attccggtaa 39600 cggtcgaaac ggcgtccgct acggccccgg acggctccgc tacggtgtgc aagcttacta 39660 agccggccgg gagtaccgct tacgtctccg cgccgataga tgggccgctg gggtccggta 39720 gcactgtaac gttctcgttc ttcgcgaaag ccggctccac ccgtttcatt gcaattcagt 39780 cggctgccga tttccccagt cgagccgatg ccgttttcga cctggattcc gggaacgtaa 39840 tcagcgatca gatgctggac agcagcgtgg taagcgcccg aatgattcgt ctggaaaatg 39900 gctggtggcg ttgcgttctc acgaccaaga ccgtcagctc ttcgttccgc gcggcttaca 39960 tcgctccggc agaaaccaac ttcagctgga ttgattcgaa ttccagcgcg gcgattgacg 40020 tgcttatctg gggcgctcag atcgaactgg gtgatactcc aaccggatac ttggagacta 40080 ccggaacgcc cgtcaccatc accgattacg ttctgcagag cgcccagacc ggaacggtca 40140 agttcacaca gcctcttccg accggagtag aagcgtattg gactggagac tggaaaggtg 40200 ggtctgcgac cgagccggcc agattcgcag taggggatgg gactcaagat acattcaatc 40260 tgtccagccc tgcatacatc ggcctaccca ctagtggggc gttcaagcta gaatacagag 40320 ttggtccggc gcttaatttg tcgccgcaat tgatcaacct catgaatgac cgggcggtcg 40380 gtatcatgcc gacttgcgcc ggttgcgatg taaaagtcat tcaggagtaa tgacgtgatc 40440 acacccgaac tgatacccag tccgtttgct gcgcagggcg acaaagaccc gattccacaa 40500 acctcctcca ctggcttcgc aaaccttcgc gacggctata cgccggacta cgaaatcagc 40560 ctggcgtcga acaacccgca ggccaaagcg gtcgagcgga aaattcaaaa ccaactcttc 40620 ttcatcgcga cccagaacgc acaggcgtgg cagcgacaaa tggcgccgcc gtggtttcag 40680 ggcatgcctg gcggctacga acagaatgca gaagtcgtgc gcgtcggaaa tgacggcata 40740 atgcggcgtt atcgttccat ggtgaatgcc aatgcgagcg accctctcag cagcacgact 40800 tgggaagaac aacccgcatg gtcggcgatg cgctccaaca tcccgatgcc ggccggaggc 40860 ccaggcctat cttctggcgg agaagtcatc acgaccggcc gcaacttcaa cgacctgtta 40920 aatgggacgt gggagttctt ctctgattca gtggttatcg cttctcagaa tgcccccgta 40980 tatccggctt ccgctggtgc cgctgctggc atgttggagg cgaaatcttg ggtgtccgga 41040 gccaatacgt tctgcgtcca acgctacact gatcgcgtcg ggaacgtcgc tgtgcgcggg 41100 cttaatgccg gagcgtggac caactggatg tatgcggtaa acgtcatggc tcttcaacaa 41160 ggtcgggtca cctatggagt cgcggccgga tcggcgaacg cttacacgtt gacgctagtt 41220 ccgcagctcc aaggcggcct ggtggatggc atgattcttc gggtcaagtt caacaccatg 41280 aacaccggcg cctccaccat caacgtctcc ggactcggcg ccaaagccat cgtcggcgcg 41340 gccaacttcc ctctcaccgg cggcgaactt ggccaaggac tcatcgctga gcttgtattc 41400 gacgcagcag gcgaccgctg gagaatcctc gcaggcgcgc cacgcatcca agtgggcaac 41460 gcagatcagg actaccaggc ccccagctgg aaacaggtga aggactatgt agcgtcccaa 41520 aagctcaccg aagtggattg ggccgatgtc gtcaacaagc cgaacgtcgc catccaagac 41580 accacgccgt ggttcgccaa tctggagctg tctgacgctc ggcctttcat cgattttcat 41640 ttcaacaata accgcgccaa agacttcgac tatcgcttta tctctgaggc tgatgggtcg 41700 atggcattct attctcgcca ggggtctgcc ggtcctaccc aggacatcct gttcagcagg 41760 tcgaatgtaa cattcctcca gccgcgactg gatgttgcga aaaacctcgc gtacatcgcg 41820 aactctggcc ccctttggca gaacaccaca gccgatcagc ccggctggaa attcaccttc 41880 gcacaaggcg tggacgcgaa caacaacgcg gtgatcgcag tcaataccac caatccggac 41940 ggttcctatc gctcacagat catgcgatgg gactgggctt ccacgaacgt catattcaat 42000 aatcgtccgc tcttcgccgg tcaatacacc ccttgggatt ctgggaactt taatccttcc 42060 accaagttga ccgtgaatgc cacgaaccaa atcgccggcc cgaccgggat tcggaataca 42120 aacggcaaca ccggcaacat gaacacatgg ggttccggtt ccacaacggc atcctatggt 42180 aatgctgcca ttcaaatctt cgggaaaggg agtggtgagc ctgccgcgat ctatttcgac 42240 aactcccaga caggatggta tctggggatg gacaaggatg gacagctcaa gcgggccggc 42300 tggtcgctcg gcaataacgc ctacgtgatt accgacgaat ccaacattcg tttccacgtg 42360 aattccatgg ctggcactcc tgtttggggc ggaaacgaat tctgggggcc gtggaacttt 42420 aatccgaaca ccaagctgac catcaaagcc ggcacccagg aaactagcag cactgcgata 42480 ttcagcggaa ctatgccatt cgctccaatc gcatcgctgt ccgattattc tcaggcccct 42540 ttgacggttt acaacgcgcc aaccggtccg tctgcaaaac cggccgtcat cgcgttcatt 42600 cgtcctggta actggggagc attcttcggc atcgataccg acaacaagct gaaatggggc 42660 ggcggatcac tcggcaacag ctccagggaa atcgccgatt caagcaacat catgaatctt 42720 tgggcggcca acccgaccgc gccgtcctgg aacggccaaa ccatttggcg atccgggaat 42780 tttgatccgg caacgaaagt ggatttgaac gccgcgaacg ccaccaacgg aaacatgatc 42840 ttcaaccgca tcgccggaac tggtagcggc atagcttcgt ccggtcgagt cggtgccatc 42900 aacctgcaga acggggcgca ttcggggcaa gcggcagcag tcactttcga gcggggcggc 42960 agtatcttcg tcaacttcgg cttggatacc gacaacgttc tcaaagtagg tggcggaaac 43020 ctgggggcag atgcctatcc ggtcatccac gccgggaact acaataacta catcaaccag 43080 gcgctggttc aggtgggtct tggcggagtc ggttcctatg gaattttcgc ggttctggat 43140 tatgccgctc caaccgcaac cgttcaaccc ggagtggtcg tggacggttc cattctcatc 43200 tactcgtctt gcgccgcaaa ctacaatagc ggtaaaagac ctgccggaac ttggcgctgc 43260 atgggatatg tagtcaaccg ggatgccaac acccctgact ccgcgaccct tttccagcga 43320 gtgacgtaaa aatgaaatgg acgcggatca gaaacccacg ttggctggac gcggtaaaca 43380 tccacgccat ggttactttc gaggggattg gagaagttcc tttcaccgcc aatccgcacg 43440 acgtggaggc ccacggaagg gccattcacg ctgcgatcct gtccggggcg cacggaccta 43500 tcgccccagt agactcgacg cgggagcagg ccttgcagga cgctatacga gacagggaaa 43560 agcgggctat ccttcgcgat acccgatggc ccatagatcg tcacgacgag cagaggcggc 43620 ttggtatcga aaccacggac gggcctgggc tgatagcagc ccttgttcac tggaggcagc 43680 agattcgcga ttggaatagc ggggatcggc cgcgacttcc catggctctg aaaacaatgt 43740 tcaaaaatca ggagtattga tgaaaatcac gaaggatgtt ctgatcaccg gaaccgggtg 43800 caccacggat cgggcgatca agtggctgga tgatgtacag gcggccatgg acaagttcca 43860 catcgagtca ccgcgagcca tcgcggccta cctcgccaac atcggcgtcg agtccggcgg 43920 actggtaagt ctggtggaga atctcaacta cagcgcccaa ggattggcca acacatggcc 43980 gcgccggtac gcagtagacc cgcgagtccg cccgtatgtc ccgaatgctc tggcgaatcg 44040 tctggcccga aacccggttg ccatcgccaa caacgtgtac gcggatcgca tgggcaatgg 44100 atgcgagcag gatggcgatg gttggaagta tcgcgggcgc ggcttaatcc agctgaccgg 44160 gaagtcgaac tattccctgt tcgccgaaga ctccggcatg gacgttctgg agaaaccgga 44220 gcttctggaa actccggccg gcgcgtcgat gtcttctgcc tggttcttct ggcgcaatcg 44280 ctgtatcccc atggcggagt ccaacaactt ctccctggtg gtgaagacca tcaacggcgc 44340 cgcgccgaac gatgcgaacc acggccagct ccggatcaac cgctacatga agaccatcgc 44400 cgcgatcaat caaggctcct gatattcgcc caaaagaaaa ggccgcttat tcagcggcct 44460 ttttgctttc cggctttgcc tcttcaacca gcttgacttc aaccggcgcg gcggactctt 44520 cctgagtgac cgaatccaca tagttcccta gtgaactcag aacgccgatt aacagcgctc 44580 ttaccacctt gtccttgact gtctcgccta tgatcttggt cagaacggat atcaactctt 44640 cccggagtct tgggctgatt cttggccgaa agcgcttgcg atgctctttg cgtttcatgt 44700 ttagtcctct gtctgcggtc ttctcctcac cccgataatg gcttggggat gcgttgtgtt 44760 aatcggaagg gtcgggcgct attataaccc gtcgaaaatg ctcgcgctta actgtttaac 44820 gatacgcacc gcgatattaa atcgccttct ttctggccaa ggaactctgg cggccgggtc 44880 cggtctaagg cctaatttgt cgacattaaa acgagaaaac ccggatcgcc tgtagggtaa 44940 ggcgtccggg tttatttcga tctagtgtcc gctagaatca gtggcttccg ccccatccgt 45000 ccagccagca atcgaagacg gcgtgtctcg gcttgtcctt ggcgccatgg gagaagtgct 45060 tgaatcggat gacctggccc ttgaggtatt ccctgtcatt ccagcggcgc tgtttctcgt 45120 cgtgggtcag gctggaggcc gacacgttga aggtgactcc aggccacaga cgttcgttgc 45180 ggcagacgaa cgcaccgacc attccggacg gcgacaggtt ttctgcgtgg ctggagcggg 45240 ccgtgtggcc aagttcattg atgaaagctt cattgttgtt gtgcatcaac tcttccacgt 45300 cgatgatctc agcttcatcg tagtcgtatc gcttgacttt cacacagtgc ccttccttgg 45360 cagtcgagcg accgaacttg tacagtccat cagcgcgctt gcccatggaa ccttcgaatc 45420 ccagcattgt gtggcggcgc tcgacttcgc tgaactgttc gatggaagtc accagttcct 45480 gctcgaccag gtgaatcctc tcatagccga ggcagtgacg aaggaagttc acgcgctcgg 45540 ccgccctggc taggcgatct tcggtcggtg cgcgaggatc ggtgaaatca tcgaacacat 45600 ggaaagacca gtccggctca ccgctgtggc ggcgaagatc gccggacgac ttctggaaaa 45660 ctttcgggtc gctgatgtcg ccgcagacca gctcgccgtc caggccgttt aacagtttat 45720 cgctgaggta ttcgtagatc gattgattgt tctgccgctt gagttgacga gtcagcgcct 45780 cgccttcgaa tacgaagcag cgaaatccat cgatcttcgg cgagaaatac atcggcagtt 45840 ggccttccag cagcttcggg tcaaaattcg atgcgagcat gggtttcata cagttctcca 45900 gaaaagaagc ccggcgaacc gggctaaatg gcggtaagcc ggctcagatg gtttcgttgg 45960 cgtggttcag ttcggccatg atcgacgcat agcgctcgtc cgactccttg atgaacacgc 46020 cgtcgtacat gacgcctttg cgatccttga tggtgtcgta ggccgcagcg tagcaggcga 46080 gcatggtagt gtcgtgctct tccgtcacat cgaacagagt catgacggcc aataccaggc 46140 tcttgatggc taatccatga tttccgcgtg ccagcgcgcc ggccagatgt ccgaggtgct 46200 gcaaatcgtc gccgtaggtg ggatgaactt cgacagtctc gctgaagacc gatagatgat 46260 cgaacagatt ttcaccgagt tgcgcggcca tgatcgtggc aaccaccatt acgtcgccga 46320 tgccgtcttt cacctcgact ggtttgttat aaacccaggc ttcgcaaact tctgcgaact 46380 cttcgaccaa cttcaggaat tgatccttgg ccgaagagcc tttgatcagg ttccggtcgg 46440 aaccccattt aacaaccagg tcgtgaagtt cgcgactcat gatttgttcg atattcattc 46500 tttcgattcc ttttggattt gggattttac tgcgttgatt atggacgccg tgctctggcg 46560 cgatccatcc ttggtggtgc cgaagtagaa ggccattacc gacttcagct cggcgaacca 46620 atagccgatg atggtgccga tggcgaccga ggatgttggg tccatcagag cctcgcggcc 46680 gaatgtgaag attgcgatga tgatgagaat ggagcctgtc agaagagcga atgtgatcgc 46740 cgggcgaacg aaatcgttct gctgcgccgc aagcctcctc gcagaatccc tgtcggccgc 46800 ctctgcggcg aactggctaa gctcggcctg gagctggttc tgctcagact gaaggcgatt 46860 ttgttcggct tgaatcgcaa gctcctggag acgaacgcgc tcggcgctct ggagttcggc 46920 gagacgcgct agagcttccg gattcgcgtc tagagcgcta gcgaccgagg ctgggtcggc 46980 cttcgacccc agcgccgtag cgacgatagc gccaacggcg gcgcctgcag gcccacccag 47040 gagcgacccc agagccgggg cagccgcgcc gatcttacta cctatgtctt tccagtccat 47100 ttcgactcct caaaagaaag gcgccattac agcgcctttc tccggccggt gatttagaac 47160 tcttcggctt cggtcgcatc gccgacgcca ccggcgtcac tgcgaggctg ttcctgcttg 47220 ctgtagtcca ccttcacctc gccgccgacg aacgacttgt acaggtcggc cgcagccttg 47280 aagtgatccg ggttcttcac caggccttcc agctcgaact ggacgccgga ccagctaccc 47340 ttgtcgttcg acatgcctac ggtggtcatg cggaccaggt tggcgaaagt cggcggggtg 47400 cgcaggccct gcggggtctg aacctttttc tgggacagcg cggtcatgag cttcttcgag 47460 gccttgatct gcgaagacga cagggagatc agagcctggc cgaaatcgcc ggtgtccgga 47520 tcgatgacga tgacgtaatg accacgggtg tcggcgaagt agtcagactt cttgtcgctg 47580 accgaaccgt cttcgttcgg cgcgtacagg cgtccttcga cttccttcac cttggtcggg 47640 tctttcatca tttccttgaa gtcttcgacg ctgatggcgc ccttgaaacc gccctcggcc 47700 tcgcgacctg cccagcggat gaactcgcgg cggtacgcgg ccggaatgat cagcaggccg 47760 gtcttgccgt cgtaaatctt gccggtgacg gtgttcagga acatgccggc cttcgcgcct 47820 tcgatgtact tcgggtcatc ttcatcgacc tggggagaca tcttctgcag aacctggatg 47880 aaggggatgg cataggactc ggcatcggcg ccttcgaagc ctgcgccgtc atacgatccc 47940 aaatccatga agtcgggaac ttcggtagtc gcgacggcgc cgccaccggt ggcaactgct 48000 acggccttgg tttcttcggt tgcttcggaa gtttcggttt tcttaccagc catgttaggc 48060 tccttgtttg tcgaatttca gttatcgcta actgtgggtt tataataacg gaagttgcaa 48120 ctaagtaaag caaattacat atcaagattt gctctttttc accttcggtt tcgtgatctt 48180 ggcctctttg tattcgtgta cgccgatgaa atctggcagc tcttcgccct tctccaggta 48240 ctcgcgaccg aacgcctgga gggtctggta atggacatcg cggttgatgg tggcgtcata 48300 gccggcttcg atgatggcct cggccgcctt cttcgcatct tccatttcgc cgcgaccgaa 48360 ttcggccaga accttggtct tgatgatgcc gtcgttgtcg gtgtcttcca gccacttcca 48420 gaacttcgat ttgttctctt ccttgacgga aatgatggcc ttcggctcta cttttaccgt 48480 gcgaccgtcc gccagagtag tggtcttctg accaagctct tccaacagct ccggaatggt 48540 gttacgcttg agggtcttca gctcctcttc cttttcggcc agcgcctttt gaagatcgag 48600 gatttcgccg tccagctgcg aggccttgtc caccaagttc agcagtcgat ggccgatgtc 48660 ggtggcttca accgccattt catccatgac gccaaaatag tcgatttcgc ccggcgcgtt 48720 ctctttcaag tattccggga tttcaagctc ttgctctttc atgtccgcct ccaacttagt 48780 gatgttccct tacttgaacc aagtattgag tagatattat gccgcatctt ccttgatacg 48840 gctactgatt tacatattaa atttcgtcgc gagtgctaac gtcagcctca aacacgccat 48900 caacgacata acttgccagg ttgcgtttcc actccaagct gacctggatt ttctcgtcga 48960 tggaatccag acagatcagg tcgaagtaca gaaccgagtt gacggtgccg attcgatgat 49020 ttcggtcttc ggactgcatc cgcagctcgt tgtcttcgtc ggtcgtgtag tagatggcca 49080 cgtctgcggc ggtgagcgtg atcccgatcc ctgctgcggc cgggttgccc aggaacacct 49140 ggacgcgctt ggcctggaaa tcgtcgatca atttttcccg ctcggcctct ttggtctcgc 49200 cgtagtatgt gccaaacgaa attccttggg cctccagata cgccttgatc tggtcgattt 49260 cctgaatgcg catggcccag atgatgatgg agcgctccgg gtcttcctcc agcagaccct 49320 ccagaagatc agtaaacacg gcgaatcgcg ggttgtcttc gggcggcagg atcaccggct 49380 cgccatagac gttgatatag ccggatgcaa cttgcttgag cttcgaacgc gctgccgcag 49440 catcgaaaga tacgtccagc atgaagtctt cgttcttgag aacgaagtgg tagtcttctt 49500 ccactcgctg ataaaccttc ctttgctcag gcgacatttc gaaatatatg cgcttgtaaa 49560 ccttttctgg caggaatggt aatgcctctt tcttcgtgac ccggaagctg tgcggctcga 49620 tcagggaccg cagtttgtcg agatttcgga atactggtcg tccaagatcg tctttctcga 49680 cgagctgagg ggggactgta ctcttcccat ccaatttgcg catgatggcg accattcgcg 49740 gatcgtcgct gggaaccaga acggaaaatt cagccacgaa cgcccgatag gatttcgtgc 49800 caagaatgcc atcgcgtagg aattgaaact gcatgaacaa gtccgtaggc gctcgcgtca 49860 gaggcgtgcc agaaagtatt cgacgtgcca cggccttctc gcccagcttt acgatctttt 49920 tcgcgcgttt tgcttgtggg tttttgatcc tcgtggattc gtcaacaatc gcgcacactc 49980 tgaacgtctt gaggaatcgc tcgacttcgt catagccaga ctgatggttg atggcatcga 50040 cgttgatggc aaagacccgg agaactttct catcggcgaa cgtctcggca tacagacgat 50100 ccaaacgcgc cctggccttt ttggaagtcg gtctgccgcg ccaatccacg cacagagtct 50160 tgactgcgac gtgagtagga atttcgcgca gaatccagtt agtatgcacg cctttggggg 50220 cgacgatgag cagcgcgtca acccttcctt gcaggaagag cctaactgag tctgccaaag 50280 tagtccatgt cttcccggtg ccctgttcca tcaggtaggc gaaatttctt ttgtttaggg 50340 aagctgccag ggcattgaac tggtgctgca tagcctcggt cttcataccc ttgactggaa 50400 aggttttggc tttcatttgt tctccagatc tgcgaggaat tggatgatat tgtccagtcc 50460 ttctgcatga ctcgcgactt ccaccaggtc gcggctgtta agatcgaaca gatcgagcat 50520 gggattcaga agcagccaat cggttccgat ttttgccagg acgaagccgc gaccacccca 50580 gccaatccgc tcccgaagga aagggatttg cccaggctcg aaacatcttg ccattgggca 50640 ggtggaggcg cgtttcggcc actcctccaa cgccttgaac tcgacccaga actggacacc 50700 tcgacgattc aggcaaatcg aatcggacat accagaccgc cgcgtctcca gaaagtcgat 50760 caggattcgg ccgagcgagc gctgcttaaa cgcattcgcc gctttcgtct cgcgatcatt 50820 catcgccttc gccctctttg gaaactttct tagtttgctc ttccagtttg gccttctcgc 50880 gctcggtcaa tatccgtttg atggccttca cgatgaacat gtcgatgccg ctgagcttcc 50940 agcctttgat caggaaccaa gagccggtcg gcgtcccttc ggcgatctgc tttccgtatc 51000 gcagatattt ctcaggcctg atacggaatc ggatttgttg atcaaccgaa tcatccacac 51060 acatgatgtc gaggaactgc gactggccct tgtacaccgg gtttttccct tggtcagccc 51120 tcttcttctg gcgaatcggt tcgttctcat ctgacagaac tttcttcacc atcttgacaa 51180 taaccaggcc gtcgtcgcca tcgcggatat cccgaatgtt ctgaatgggg tttccggaag 51240 ttactccaac cagctccgga ttgtcataag catgacccca gagcgtgtga gcttcgttca 51300 agtctgcgaa ttgaacttca gaattcgaca gactcgcggc gactttctcc caatcctgaa 51360 gcgtcttcag gtgggagccg gccagctcct tatattgggc cttcagctct ttcagatcgg 51420 cctttagctc cttcagatcg gccttcaaca gtttctccag ttctttgtct cggctgattt 51480 tcgccgaaag aatctgggct tccagtgctg ctacatcagc ctcctttacc tccacatcct 51540 gcgccgatat cgggcaattg gccagggcga tccttgcggc cttgacttcc tcgcgaaggc 51600 gcaggaacct ctcggccttc gccgggccga agcctttggc gttcatgatg ccgccgatca 51660 ggcgcccgtc cgccaccacc cagttgagtt cggaatgctc cgggtccagg gccgtatatt 51720 ctacgccttc tttggccaat tcgcgaagga tagacacagt ttgctggtcg tccttcgccg 51780 cccgaaggca cgcggccgcg tattccaggc gatgataccg cttcatgtag caggtccagt 51840 acgtcaccac agcgtagctg accgagtggg agcggttgaa tccccaggct ccgaaagtca 51900 ccatttcctg ccacacacgg tgagcatcgt ccggggcgac gcctatggtc ttggcgccct 51960 cgatgaacaa ttcccggcgc ttgttgaaga actcttcgcc ctttcgcgca gacatggcct 52020 tccggattgc cgatgtctgc tcccagtcga actgtccgat gtccttgacg atggacatga 52080 tctgttcctg atataggaag acgccgtacg tccctgacag atattgctcg acctgcggaa 52140 tggtataggt cacaggctcg cggccggcca cgcgctcgat atacttggtg gccataccag 52200 aagacaacgg acccggacgg gcgagcgccg tgatatggtc gatgttttcg aacgcggtga 52260 tattgatcgc gtttgcgacc gaacgaactg cctgcccttc gaactggaaa atgccggaca 52320 ttttgtcttc gttgagaaca tccaggaccg ccttgtcgtt caaaggcaag tcgtacaact 52380 cctgcgcagt cacacagttc gcgtcctgga tgacgcccag agttcgaagg ccgagcgcat 52440 cgatcttgag gagattcaaa tattccgaat ccggcttatc gagctgcgcg acgccttcag 52500 aagttaccgt acagaagtcg ataacttcat cgttgcagac caggatgcct gccgcgtgga 52560 ctccagagtg ggatgggtga atttcgaggt cgcccatgca ggcggacgcg atctcatact 52620 tttcacggaa gtcgcggccg ggttgagttt tttcgaaagt gtcctccaat ccttttccat 52680 accgttcgtc cgccgacgta tattcaatga tcgagttttt gatgttgtcg gtatcgtgga 52740 aggggatgcc gaagcgcttt ccgacgtgag cgataaccga cgcggccttg agcgtattga 52800 tgttgcccaa cttcaccacg ttccaagtgc catacttctg ctggagatat tcgaacacta 52860 gatagcgatg ggtatcggcg aagtcgatat ctatatcggg aagatcggac cgggaaatgt 52920 cgataaagcg ctggaagaga aggcgatgag ggagcgggtc aacctcggta atgccaagga 52980 gatagcagac caaagagcct gccgaagagc cgcgagctgg gccgaccagc atatgcttct 53040 tggcgaacgc gaccagatct gccacgacca ggaagtagct gtcgaaatct ttcagctgaa 53100 tctgcttgat ctcttcttgg aatcgatcct catactcctg ggtccattcc ttgatgtggc 53160 cgcgactgag gcggtaggct tgcccctcgc gagccagagc gacgatatca ccatccaagt 53220 ggatcatcgg cgccttcgcc agtttcacat ccgccaaccg ctcgactacc gcacgagtat 53280 tggctgcggc agtatcgaac tcttcgcgag tcatgatgtg gcgtaaacgg ctccacagct 53340 cctcttcggt ggcgatgtgg cgaaggccga ccgattcccg caccttccag gccgacgcga 53400 aatcagcatg gtcgatggac ggcatgtcgt tgtaagaggt aattaccacc ggctttccga 53460 atgccctggc cgtctccata gcgccgtgcg cggcgaccat cgacgcggga ttgatgtcaa 53520 tgtagtcgat tccggccaga tccagatggg cataggcctc gccagcgaat ttgatgacgc 53580 cgtcagcttc ctggaattct tgcggagtca atccttgatt ctggaccgac ttggaagtca 53640 agcggtagaa cttctttgtg tccttggcga gcacccaggc tttgagcttc agctctttct 53700 cgccatcgtc ggcgcatttg atcgggattt ccatgccgaa tccgcgaggc agttctgcct 53760 tggtagcggc ttgttcccaa cggacgtggc cccatgttcc atcatcgacg atggcgacga 53820 atggggattc gatctctttg gcgcgctcga tgatctccgg gaatcgacca tatgcggcgc 53880 cgtaggagta accagagcga acgcggagct gagggaaaga catcatgcgg cctccattgc 53940 ttgatacgcc cgatacactc ccatgcgctt gcagacttcg tggagcagcc gcacgtcgtc 54000 gagcgcccgg tgtttctgta catatgggcc gcagtagtgc tcataaagat gttgcagccg 54060 catgcggtgg ccgaacaacg gcgccgactc ttccacagta cagatatcga gcgatgggaa 54120 attgacttcg tccaggccga acttgccgcg agccagatcg caggtcagca tgaacttatc 54180 gaatggcagg ttgtgggcaa tattcgcgtc ggctctggaa aagaagtcgc gaactttctg 54240 gcgctgatcg aggaaagatg ggtgcttgat caggtcttcg ttctgcaacc cggtgatctt 54300 ggtgatgatt tcctcgataa cgattccagg attgcagatg aactctactt catccaaaat 54360 cttttcgcca tcagttatca cgccggcgaa ttcgatgatt ctcggctgct ttctcagact 54420 caccctttgg tggaacggga gtcctgtggt ctcagtatcc catacagcga atatcatgtt 54480 tgttccctct tatgtcgaaa ggccggctgc ttcgcgacc ggcctgagga gtatatcgcg 54540 acggctgaag attacgcct tctgtccgtc ttcggcgtg atgcggctgg agcgcatggt 54600 ggcgtgaaca aacgccgaat agttgatcaa gtccaaggcc gaatcggcat ccttgaaccc 54660 gctattcgcc aggcgagtga gtttacccac catgtgcatc acgaacaggg cgagtcgatg 54720 atcatcggcg gtcttcgcca ccaggccgtt cgggaagagg atttccatga tctttccgta 54780 catcagatca ttgcgaccat aggtgctctg gcgggcgcgg aagacttctt ctgctgcgta 54840 cagattgttg agaacatctt ccgcgaaatc atcgggatgg gaatcatctt cgcccggcca 54900 gacggatgcc atggcgaacg gcgcggcgtc ttcggactga gccgtttcag cgagcggaga 54960 cggggctttc gcaaaagcct cgtcgagggt aggggcggag ttcggggcgg ccgggaacgg 55020 ctcgcctgcc atgtcgttgg gcgcgctatc ggggtcgcta tcggccgcga cggcgaagaa 55080 cggcgcatcg caaccttcca ggttcaggat gtaggagtcg atccccaggc tattgtaggc 55140 atcgatgatg tcctggcgat catcgaacgc cgcgacgatc ttggtgacgc cttcgatttt 55200 cttcaggatg tcgagcgcga ctgcccgctt gaactgaggc gccggctcgg tgttaccata 55260 cggccgcatg atgagttcat actcgcgatg ttcggcgatg ccgagttcgc ggtggagctt 55320 ggccctggtc tggaaaaagt ggttgtcggt tcggccggtg acgaagaaaa tcatgaggtc 55380 ggcgtcgatg gcattcctga tgcgacctac agcgtgcggg ttgagagtgt ccttgtcgag 55440 acgagaatga tactcgtccc attgccgttc caaggcgaag ctcttgcggt ggctatcgtc 55500 gaatacgcag ccgtccaggt cgaagatgat gatgccattc tttggtttgc gttccatatt 55560 cagatttcct cgctggttgc tttctgggtg acggttttat cgatgaacgt cccatcagaa 55620 gtgaggcgga aaacttcgcc attctggatg aaatcgaacg attgcacgtt catcgtgatg 55680 cgaatggatt cgctgccgtt ggtcacttcg acttgtgcga tgtcgccaac tttctcgaca 55740 atgatcttca tgttacatgg acttcccgtt gacggccaca gggttggcct cttgtttttc 55800 cgatccccag aactcgcggc gcagttcttc ctgctcggcc gagcgatcca tccaggggcg 55860 atagaactta cactggtaga taggttccaa cggaacatca accacaggaa tctggccggg 55920 cttcgtctcc agagcggaca tgaaccggtc ataggatttc tgctggattt cctcttcatt 55980 catcaccttc gacccatagc gcgggaaggc gcaggagccg gtggcgacgc agtgcggctg 56040 gagtaggctg tcgaacatag gatagacttc cagaaccagc cggcgcattt cgcggaatac 56100 ttcctgatat tcaccctggg tccgaacgca caggcgaacc ttcgccatgt cgctgagagt 56160 ccgcagattg aacttggccg cgatcttcgt ttccatgttg gaaggaatga ttgcacgagc 56220 gtcctggagc gacgcgccgg cctccagaag cttctggtag ctggtttgcg cgtcggcaat 56280 ggcgtcatgc cacagacggt tcagctcttc gcggacatgg taggtcgggt caggctcgcc 56340 atttaccgta gccggttcgt cgaattccca gcggaaagct tctggctgaa cgacggcgct 56400 gatttccaga gcgcgactgg tttcctgctg gtaagccccg gtacgagtcc gaacgagttg 56460 atgggtgaag ttcttgctga caccctcgat ctggaagatg aagtccacga actcgaacgg 56520 cgagcggatg gtgtccagca tgtacttcca gtggtcgagc ttttcggcct cggtcatggt 56580 cgccgggtct tggccgcgca tgcgggtgga cttcgttccc aagagcaatt cccaggcgtt 56640 ctgggtgtaa ctaatcagag aaatcttcat cagaaatctt ccggaattgg cgtgaagtgg 56700 aatttttcgg tgagagccag ggccaggcct tgggcttgct ccctgttaag gccatactgc 56760 tctatctctt ccttgagcag ttcgcaggcc tccagacgcg cctcatactc ttcagcctca 56820 tggacggatg agaagacggc tccatcagag gttcggtaca caagttcgat cgccatggtg 56880 acctcagtag cagcggatga tttcggcgcg gatgtcgcga cggtcgaggt agtgctcacg 56940 aatcttgtcg cgggcacgct cggcctcttc gcggctgccg aacgacaggt tgaacgacgt 57000 gaaaggctta tcgtccagtt cagcgccggt ctgatacagg atgcctacca gaacgaaaga 57060 cggcgcggtc ttcggctgct ggtcggcttg catttcgagt tcgaggaagg acataggaac 57120 ctcttcagga tgatctggtg cgtaaattaa tagcgctcct gctgagcagc tacggtttcc 57180 ggctcgtaga tgagcatgtc aacgatttcc gggcactggc ctttcaccca gtcgatggcc 57240 gcgaccagtg tggtggaagc ggagaaagag aaagtgcggt aagactcatg gatgtacggc 57300 gaccccatcg aatcgcgctc ggtcgtgcga gaaatgactg ctttgatatt aacgatccgg 57360 cccatcttcg gcctccactt tagcgattat atcggacagg cttaacttct cgccattcag 57420 gaaataactg gcgcgaaact tcctgtcgcc ctctggcccg acgattcggg ccgttatggt 57480 gagactcccg ccgccaaggg catcggtgtc cctgaagaaa gtcagcagcg cccgcttgag 57540 cgctgcctcg cgaggatcga cggccattaa cctaccacgt tccagccgtg ctgagcgcac 57600 caaaccgcac cggtccctgc aggaaggcta ttcagaagga acacaggagt caggcggcca 57660 tcctcggtca tatggatgaa gtagcgggcg cattcaccta gccattcggc cttggcaata 57720 gcgcgttcta gattggcctt ggtggcgtag gtcttggtgg tgtttttgtc ggtggagaag 57780 attacttcgc gggccatttt gtcgattcct tttggttgaa gggtttcgcg tttcgatgag 57840 ggaatactac gcccacctga ctcagaagta aagcaatttg tgtaaattac ttcacgaaca 57900 ttttcttggc cttctgataa gacgaagaag tcatcaggcg ctcaatgacg tccatgtccg 57960 aaaccagatc gtccagaagg acgttgcgcc aggtagcgaa ccgaccgagc gagaagatgc 58020 cggcttcatg ggtgagattc cagatcatgg attcgcgctc gtcgcgaccg agcggaatga 58080 ttttgccttt ggtctggatg gtcggctcgc catcttcgat gagatgcctt ttcctgatgc 58140 cgaaggccgc gcaaacgtaa tccatatccc agtcgctgtc ccattcgatg gtttcgattt 58200 taccatctaa agtctccact atccccttag tgatggattc gacgatcaga gtatcaccgg 58260 tgatggacgc tcgaaacgtt cccactttag gaccagggaa atacacggtc tggaagacat 58320 cacaggggat ggaaagcttg tatcgactca cgatgatgga ggttccttca ccgaatgacg 58380 ggtcgattcc caggtccagc cctgccgcag ccagattggc gcggaacggc gcggtgctga 58440 tgatattcac gtggtcatct tgccggcgaa gatactggaa gaaagaggcg tcgaaaggac 58500 ggctccaagt gatgcggttc gctagcttag ccaccagctg ctcatagtag tctgccggtg 58560 cgatccaacg cttttcagtc gccagattcc agatggaccg gtccgacagg ccgcccgtta 58620 ctttcctgga gtacatattg cagtggtcga tgcgcggctg ggaaatgaac tcgccgtcga 58680 tgtagatagc cttgtgtaca gtgacttcgc ggaacgggat gccggttagt tggccaatca 58740 ctggcgagcg gaatcgcaga agtgcgttgt ggcgctcctt attctccggc gtcgccgcgt 58800 cgatgatttg ggcttgagga aagcgatgcg cggcgatcag tccggcgagt ccggcaccta 58860 cgatgattac tttctgatca ggaatcatga tgtgtccctt atgagtgtac aaaacttgag 58920 aggataaaa agggacccat tttcatgagt cccttgaaga gctagacgat tcggtctcag 58980 aagagcggcg gcttactctt cttcaccatc ggaaccgtcg gcgccctgac cttcaccgtc 59040 gtgctcctgg ccttcatcgg ccttctcgtc atcgccctgg ccagcttcgt cttccttcga 59100 agcgatggcg accagatcga cccagcccat gatttccagc ttgctcagat agctgcgaac cgaggtgccg tacagcaggt gggccacctt ctcgccgag gattcgattt cgaccggctc 59220 accaacggtg cagtgctcgt tgatgtaagc aaacaccttg ccgcgagtcg agaaggcctg cggggttcca tggccgtcgc cggtcgggat gaagtgagtg gcgcggggc gacgcgagcc 59340 gttggacttc aggtcttcgc ggcgggcttc ggccttcgcg cggcgctctt cctgctcttc 59400 cttgcggcgc tgcttctcgg cttcgcgctc tgccttcttc tgctcggcca ggcgcttgcg 59460 ctcttcttcg cgtgcggctt tctgggcttc ctgcgcggcc ttcttctctt cggccttctt 59520 ggcgcgctcg gcttccttct cggccttctt ctgctcgcgc tcggcttcct tcgccttcgc 59580 cttctcggcc tgctcggctt ccttcgcctt ggccttttca gcgcgctcgg cttccttggc 59640 ggcggccttt tccttcgcct tctcggcgcg ctcggcttct ttcttctcgc gctcggcttt 59700 gcgcttctct tcgcgctcgg ctttcttctg ctcggcttcc ttggccttgg cttcggcctt 59760 ctcggcgcgc tcgcgctctt tacgttggcg ctcagcagcc ttctcggcct tgcgcagggc 59820 agcggcttgt tccttggtca gctcttcgcc ttgggtctgt tcgttctggt ccttctgttc 59880 catgttctta ctccgggaat gtttaaaggg atggcttatt ggcctgtgag aggattatct 59940 ctaaactaat tgaagaaggg aataccctta gcctgaactt tcctaaatat tttctttcgg 60000 gaaagtccaa actctaggga acttatttat gttcgagaag ttcctagctt ttacgcaaga 60060 acagtaagta ttcgattgcg cgagttatcc cagtatacat caactgacta taagggatgg 60120 acggcaagtt ttcttctaac atggcaaccc gtttccattc tgaaccctgc gacttgtgga 60180 acgtcatcgc ccagccgaag tcgaatccgc caatagcctt ctgcgcctcc agccgcacgt 60240 cttcctcgac cgaaaagctc agagggttga acttcaccca gcgttcatag ttcgtgccga 60300 taatgcgaac tttggcgaac aacatttcat caggctcgtc gtcatcttct tgcccttcag 60360 gaactggctt gaagtccagc agaatggctt gttcgccgtt catgatgcca tattcgtgct 60420 ggttcccagt gcacaccagc ttctcaccga ttcctggctg cacgcctttg tagccgagga 60480 ttcggcgagc gcgtgcgttc aagcggcggc gagtattgtt gtaggcacaa agaatcacgc 60540 catcgtcgtc caggaacgtt cgcatttcat catcagacat atcgaagccg gcccggacca 60600 atatgtcgtc atactcgcgg cagggcaggc gcttgccctg tcgcacgaac atcgacgccc 60660 gaacgatgtt gccggcatta cgctcgattt cggtcatgat ggtgtcacag ctgttctcgt 60720 ggaaaatttg gacgccgcgc acaggaggaa cttggccaaa gtcgccaatc tccaaaaccg 60780 gaattcggtg cgacagcaag cgctcttcat cccactcgcc gatcatggac gactcgtcga 60840 gcacgaccaa cttcggcttc tcgtcgagcg agtctttgtt ggcaaacatg atttcgccgt 60900 cttcatcttc gccaatcggc cgatagatga agctgtggag ggtccgggca ttgatgcaac 60960 ccttctcgcg aagccgcgct gctgccttcc cggtcggcgc gacgaagacc gtccagtcca 61020 tcgagcagca aagttcggcg atgatcttcg cgatggaagt tttaccagtg ccggcgaatc 61080 cggcgagtcg atagacctgg cggcggtgcg cccgatcaca ccaaccgcga taccagttca 61140 caacggaatt gatcgcgtcg atctgctgat tgtttggccg aaagccgaat cgctcttcga 61200 tctgatcgac ggtgaaacta gatgctgaca tatttgcgtt ctccaacgct gggtttaatt 61260 gaatcgaggc taagtttaag cacgccatcc acagaccatc cagtatcacg acgatacttg 61320 cggccttgcg gatcgacata gaagttcttc gtgcgccgca gcagtacata atgccaggca 61380 gctcccagcg catgaactct tcctttataa gggaaggcct tcgcctgctc tgcggcctcc 61440 ttggccccag ggagccagcg gacggtcgaa aggaccagga ccgcaccctt gacagcctgg 61500 gaagcggcgc ggccgtcctg tgggctatag cgatgtctat cggggtctac ccagtggtgg 61560 ttgccgcgcc ggagcttcac cgtccgggat cggccatcga acaccacagt gccttcgtga 61620 gtaaaaatgt gttccgccat cggatgttcc tttataacgt acagttatgc tttacctctg 61680 cgcaggaaga gtatactatc agctgactcg ccaaagcgag cgaatttaat ccaactttac 61740 ttcggcagga aagtggccga tactagcgcc gccgcctgta ctgccctcca aaacagagga 61800 tacattaaat gcaagaatgc aagatttccc gcgaccaact cccggtcggt aatccgaatc 61860 ccaatgtcga caagacccgc gacccaaacc tgaagcccgg tttcctgcgt cgcagccgcg 61920 agcttgaccc ggcgctggcc gttcgcattc gtcgcgagct gatccatgcc gaagcatccg 61980 acttggccaa ggccggatgg gtcaattcac agtccagcct ttatggatcg aaagccttcc 62040 cgcgccattc tgtcgttcgc gtgaccggag ttccggaaga tggagctttc atcggcatgc 62100 tgatcggctt catcgagcat cgcgagcatg gcgaatgggc ggtcatggaa gccggaacga 62160 aagaaggcgg cgccgtcatc attccagtcg atcacatcat gcgagcgtca ttcgccgaag 62220 ccgaagagtt cgccgaaaag tgggagcgga acttggggtg gcgtctcctg cgccaactcc 62280 gcgagtgcgg cgccctggcc gggactgaag acgagttcct gcggcggatc atcaatcgat 62340 acgttcgtga tcgcacgatc ctcgatcacc acaaagtcgg cgcggacaaa atctacactg 62400 atgcagtgct caaaagcatc ggtgaaacat ggccgaaaat tccttcgggg aaattcgtcg 62460 gacaccgagt cgcgcagctc ctgatcggcc acaagctagg tcgagcgggg accatcctga 62520 atgacctggt ggacttcctg gagaagttcg cggccgggcg cgataaagtt ctcaacatcg 62580 ccatctgtaa ttgaggtgaa tgatatggaa gatttgggaa agcccagcat tccggagttc 62640 gagaagatcg acgccaaaaa actttatgag gctctggaga cgattgcgga gctagagaag 62700 aagtgggacg aatccgaaaa gcgcacacgc gatctggcag aagtggaacg gccagaggta 62760 gtcggctatc gcagcgcggc ttctcgcatg gtctatgaaa aggactatgg actgcagaat 62820 cctgagtcga tgatgcttgt ctcccagcac gaccgcatag tcggggagct gctgactgca 62880 ttaacctcga tgactgaggc gcgcaatcgc tacaacaacc tatggaattg cgctggtaac 62940 cgcctagctt tggcgcaagt tgaaatccgc aaagtaacat ccgagcgcta cgcagccctg 63000 gccaggatcg ctgagctgga aaaggaattg gccgaatccg aaaagcgcgg gagcgagctg 63060 gccgcgagct attgtgacgg cgtagtaggc gatgaatacg gccatcctta ttgtcgttat 63120 aaagtggaac gcgaagtcgc gctggccgaa gtcgagcgcc tgcgagaatc aaaaggcgat 63180 ccttctggca gcttcgacag atgcatgaag atgatgtatg agcgagacga gaacgcaaaa 63240 cagctagaat tcgccctggc cagggtggcg gagctggaga aagaactggc gatggcacgc 63300 gacgcagcag caaagggtga tgctgcccgc cacgctgctg gcggcatgga aatggagatt 63360 catgagctga agacgaagct ggccgagctg gagaaacaag agccggtggc atggggagcc 63420 ttccatttcg gcgggaagcg cgacggcaag ctgtatgcgc aatgcgaaac tgaggctcag 63480 atagaggcgt atatcctcga catgcaccga agcagcgact cattgacgct caggaaaggt 63540 tccctctaca ccgcgcctgt agtccaggct caacccagcg tgcctgatgg gtggaaaccc 63600 gttccgatgg aaccgacgcc gcaaatgaca ttcgtcggcc agtccctgcg ttatgactcg 63660 gtaaacagca tcggcgagat ttaccggcaa atgctcgccg tagctccctc acccatcgat 63720 ccggctgcgc atcctcagcc gtgccaacaa ccacaggccc atcctgcccg ctgcgggtgc 63780 gagcggtaag tgccaagtaa ggagtttatg taatggaaca gcagaaacct tcggaagtag 63840 atggagccat cgtcatgacc gatctcgata ttcgcattct tcgaaaggcg aagccagaag 63900 cgcaggacga gtgcgccgtg tccatgttcg caacggcgat ccgccagaaa ctgcagcgct 63960 cccgcgataa aggccgaggc ggctggatcg actgcgacga agatattctg atcaacggat 64020 tcgccgaaca tgcgctgaag ggaaatgaga acaacctctt ggacctggcg acgttcctga 64080 tgttcatgtg ggtgcgcggc atcgacgatg cgaagattcc cccggcgctc gaaaaggcgc 64140 gacagcacaa gatcatggaa gcctggagtc gaatccatga agacggcctg aactccgcca 64200 gaaaggcgag tgctgcgcga cagttcgtgg aagtgccacg acgcaagggg cgcccggagc 64260 gacttgcatg aagcctcacg aaataagact ggcccaggcc gaagagttcc tgcgcgaact 64320 cggccgaggg attccggacg acgaacgggt gatggtcggc tacgcggaag aggccacagt 64380 ccagaccgac gagaacgggc gcaagctcaa cgccggatgg tggcccgtac cctggaagga 64440 agggaatac atcaactcca gatccaacgc ctacgcctgt atatcgtcgt ccatcaagac 64500 gcccaacccg aagaccggcc agatgcggta ctggcgcggc gaagcctctt tcggccacgg 64560 cctggcgttg atggtcgatg acatcggctc aggcaaaggg tccaagggcg acttcgaccg 64620 cgacgagttc cgagaacgac tggagccgac cgcgattgtg gagacttgc cgaacacta 64680 ccagttctgg tatttcttca aagagccgat gtcccacatg ctccagttca aggcgctgct 64740 ctattcgttc gtggaccagg tgctaaagaa aggcggcgac aacacagtca aggacgtcag 64800 ccgttacggc cggatgccat tcggcttcaa caacaagcgc gggaaagacg gcaagttcaa 64860 atatgccgac gaaacggca agcccgaatt ggtgcgcctg tacagcgccg actattccaa 64920 gcgctactcg ccggaagaga ttgcccaggc attcggcgtc cgcatcatca tgccgcagat 64980 gaagaggtg gagataaacc gcgatgactg ggtgtatgac caagtatggc tgaagtatgc 65040 cgagcacatc tgcacgaaat acaagatggg agaagcggca ggcggccagg tccagcagaa 65100 tatgtccggc aaataccgca tccgctgtcc atggggcgac gagcacacca acggcgatcc 65160 tttcggcgca tactttcgcg gaccgatacc tggagccgag cacgaatatg tgttcggttg 65220 cgggcacgat acttgccgca aagagcatcg acggacgtgg gcggccttca ctgatgaagt 65280 cgtcctgccg tacattgtcg aacaacttga acgcatcaac cgccgccata tcggcgagga 65340 gtagtaacta tgcaaaatga tcctggaatt ctgattaccg caatcggctc attgcttctc 65400 ggccttctcg tcttcttcga aggcctgaat ggctggaaaa taccagtagc gaactttctc 65460 gcgtcgcttc tgtgcttctt cgtcggcctt tctgctttaa cgtgctggtt cgtcttggcg 65520 tttgacgtgt tttagtcgac gaacggtccg gaaattttcg gatggggacg gaacttatta 65580 gctctgccgg tttaggtagg agataatagc cgtccctttc gcctcaatat gtagaggcag 65640 tgttatatcc gatcatgtaa agcagaaggc ggcaaaccta acatgattat cgacgacgat 65700 aacattcttg atgacgaatc ggggtccagt gagtttgatc tcgcgcagat agaagatgct 65760 ggaatggacc ctttgatgac cgccgcaagt aaagcggccg acgatgcgat tgcgaggaat 65820 gagacttacc gagcgcaaaa ggcagcaaag tatgcagagg cgtatgcgga accagatctg 65880 aagaagcgag cgcgattgtt gatgctcgat caggccttttg atctcccggt cagccggttg 65940 gtgaaaggac cgttcgacga cttcatcacc aagtacagct cgacttcaga cagcaactac 66000 ctcgcggtct atgatacgtt gttc 66024 <210> 3 <211> 45333 <212> DNA <213> Bacteriophage P1792 <400> 3 tcaaaaggaa gaaggaatct taagagccta taggtctatt atactacatt ttggatacct 60 tgtcaagtac tttttgatat ttctttgata atcacatgat ttacccgacg aacggtatga 120 tagggttcta taggtatacc ctaagactac ccttcgtagg ttgctggtaa ggggtaagtg 180 gcatagggtt cccttgatcc aggttctata ggtatacccc tagactacct ctgtttgcta 240 tgtcctggcc tattgcccct ttatccagta atataccaac aggtatcgga ggttgccttt 300 gatccagggc ctataaccgg gggttacccc aaaagtctat tttatcctcc ggtgtatctg 360 gggaatatcc ccccaggagt cccccagata aagtgggggt ggcctatccc caggggtata 420 gcccctagcc cctccctagg ataccatggg attagtccgg gggtcaaccc cttgagatac 480 cgttcatcgg gtggacccta gggtattcat aagaaaaatc ttagggtatt cagggggtgg 540 atcgggggga atatccctta gactccccct tgacagtctg ctggctaatc tgatactcaa 600 gacttctatg tccgggggat agcgccccag ggtatagccg aaaggctgta tgaaaaacca 660 gtagacaacc ccgtaaagaa tatggcgtaa tggcgccgcc ttgagggaaa ccgataggca 720 ccgggggaaa ccccaggggc ttgacaaacc ccgcggaacc gggtctaatg gcccccacgt 780 tctacctagg ccaccatccc tcaagtctac ggacacatgc gggggctgcc aaccaagggg 840 gaatgcctaa gtcacccaag tgtaaggccg gcaggcatcg ggggttgaca agggataggg 900 gaagcggtaa gatggccccc aagtcaacgg cataacgtgc atgactcctt cgggattagc 960 gtagccttga caataagcgg atgtgttgat ccggggcggt gtagataggg cgccttgttt 1020 atatcctaac tacaaagcta tgactctagc cgataggatt ggtccaccac gtaaatacag 1080 acggaccact tagcaacaag tcgagagact ataaagcgcg atattgacaa gccaagccta 1140 aggctctaac ataggcaccc gtccccagcc atctacggat ggttgagata caagccccca 1200 ggtagggcag gcattgggga atgccgatag tttaagctag accattcaac aaccgagtat 1260 cttaggtcta accaatcccc ccggataacc cgcttgattg cggacccagg aacggcggtt 1320 agactattga aaaaggttgg gtcaaaaggg tagccatccg agtccctact actagcttat 1380 cgtgactggt atgcgagagt cctttgggca agacgcatcc ctacctaaca ggtaaggtta 1440 ctccctacga tagccatccg gctccctctt acaagtaacc tcggagttag gtaggatata 1500 ttacaaagga ctaacccttt gcaatgtatc ctctagaggg aattaaagtg aaaggcaaac 1560 cgaaacaaag gaccgcagta tacaaaggcg gtcgcaagac tgctaaaact gatatccatc 1620 gcaacaatcg gaagtcggtc tttggtagcc cacgtctggg gcgtaacccc cttgacattc 1680 tccttaactc ctgaaacaaa aggaaatact tatgaaaact gtactcaccg cagacaaaat 1740 cctcggcaag gatcagatca ccgctggtct ggtagctctg aaatcgttca acaaggcttg 1800 gaacgaagcg acccaacaac tggcggcctc ggctaccgta ctggctcacg agcatggtga 1860 tgttcgggct atccgtgcga tgctggccat gatgccgag ggcgctaaga ccaacagcct gcgccgctac ttcgagcgct acgcaccggt caagtggtcc gaactcaaga aagagttcaa gttcgacggc aacaaacagc acaagggcgt tcgccggggg gaaaccgaag aagacttggc attgttctcc ggcatcctga acacccactg gtccgactgc ggcccggcgg aaaccgctga caatttcaag ccgatcgatc tccaggcacg gctcctgcgg ctggtcaagg actgcaacaa ggaactggac agcgagttca aggactggac caaggtaact gctgaccagg tgaatcagct gaataccctg ctgcgccaga tgttccccaa cggcgaggcg gcctgatgcg agtagtgggt 2280 ggcgcttggt tcttccccaa ggttactaag cgcacccctc accagcaacg aatccgaaag tatctgtcca tggtaaccg tgggcaggta tctagggcca agcggtacgc tgaaaggcat tgcctatgat ggccaggggc gtactatgac gcgccccagg tctatcccta gagtgcatgg 2460 tagtccgtg cattgtagcg atagactatc aggaggttc catgggtc tgtatctttg ggcaggctcg ttccatccaa gatcggggtt atgtgtctgg tttctgcgat gcaagggtag 2580 gctggcaagg gggtattgtt taccgctgga tattcaagga cggtaaattt gcctgcggtg 2640 tctactctac ggatggtatc cgtctgagcg tctgcgggtg ggtcaaatga agtcacccta 2700 cgaagcggcc cacgaaaggg cactcatggt taatcggttg cagaagctca cgaggatgct 2760 gcgggttcac cccgatccca agtggaagca agaacaacag gaattgatta agaggttgaa 2820 gaaatgacta tcgctatcgt ggtgtcttgc gtaggcatcg gatacttctt cttccgtgac 2880 tggaggaag agatgggtat caactgaccc aactgatgag gccatggtga ttcctggccg 2940 aaacccccac cggacctatg gtcgcaggct ggggagtctt gggaatcag caaaggaac 3000 catcccgtga aacgcaacga ctatcgtaag gttagccgca acatgcaagc tatcgaggca 3060 atcgaccgca agattgccaa ggtaactcgt gagttgacca actacagcgg caatcacctt 3120 ggtaaaaccc tggagttgaa caagctccgg gcaaagcgtg catcgctggc taagaacagg 3180 gcgcggtaat gtcatggaag tatattgcat gtgccgccat acgctcacgt tccaatgggt 3240 tgttgctggt agcgtgggtg gttctcttcg tcctgtcctc gaccttggac agcatccatt 3300 ttgcatcgtg aggtagtcct atgaatatca aggtgtggcc acgcaacgga gtaaccctca 3360 gttctctggt taagtcccaa accttccgta taaatgaggg tgtgtacatg gtctgcgaac 3420 tccgcagcat caggatgcag ggtgaatctg atgaggttgc cgttgttaac cttaagactg 3480 gcaacgtcat ttacatgcct ccagtgagtc tggtataccc agtaactgcc gagctgaatt 3540 gctacgaggt gtaacatgaa actccaatac aacatgatta ccagtaagat caaggttgcc 3600 tcttgggatg atctggagtc ggggcgtctg tacatccgcc aggacgagga cggggctgca 3660 aacccgcgtg tctttatgta catggaagtt gcagatgaat tcttcatcgt ggatatcttc 3720 ggtggacccg tgggtgccgt atacttcagc ggcgatgttg actgcgggtt ctaccccgtg 3780 accatcaagg ctgcgtccat cgaagtccat cggttcggcc caccggccta gggtgtgtac 3840 tatgacgctc gcccgataca tctaccactg gttggtatcc aaggttgtca tccgtcgata 3900 ccagcctaac cccaaactgt accccaactg gtccgttact catatccgtg tgtcgatctt 3960 cggcaaacgt gcaggtatcg tctatgaaat ccactgaacc acaagtctat tggttggcca 4020 gtcccgatgg tgaattccac ctgaaggtca tcaacttcgg ccagttcatc accgaaaccc 4080 tttacgaact cggcattccg gtggaccaca aggttcatcg ggtccactga ggtgacccat 4140 gacaaacact accttcactg tagcagcaac ccgcccccgg aacgaccttc acatcagtaa 4200 gcgggcggat ggggtttatg tgaaccctaa aaactctggc gatattgcct tcctcaagga 4260 aggtaataag gttgtcgtcc tcagccagag cgggttcagc atcctcgaag cccagaccat 4320 gcccaacatc ggggaactct acccggctaa ggaggtccat gtatccgcca aggtgtgggg 4380 accgtatgaa gagtaaacca atgatcggcc agataatggc ccaggagcgt cgcatgaagc 4440 gtcgggtaga gaaacgagag ttcaacatga ctcatcagga aggcccccag gagccccgtg 4500 gtgagcttgg tttcaccctg gcagccgtag gtgtggagtc gagccgatcg gcttacctgc 4560 ggcacgccag ggaggctatg atccaatctg gtgagccttg cccccactgt atgccagtct 4620 tcggtcccaa agagggccgt tgctgcaact gcgcgaggga ctggtgatgg atttcggtaa 4680 tctttggtgt ctcttgggcg tccatcggta caaatggtcc gcagcaaatg atgacatacc 4740 tcctgataat cccagcgatc ctggcctaca tgtcggtagc cctcatcaag tcaaccaaac 4800 gactaatcaa aggagattac taatgcaccg cagagacttt ccctcctgct gtaccgcaaa 4860 aatctacatc ggcatgggcc cctcgggtac cgctgaccat tacgccggcc tcgcatccaa 4920 cgggttcagc ccccgtggtt tcgcccagga actgatcggc gccatccgtc gtgagtacaa 4980 cgagggccac ggtacgatgg tcttcacggt gaacagcgag caggtggtag cagataccat 5040 cctccgccgc atgggcagcc actacaaccc ctgggcatcc agcgacaacc actcgaccaa 5100 ggtccgggtc cacgtcatca acgtgcaagc tgcggcggag atcctcatct accacggtgt 5160 ccccggtact gtcgagcact cggaatacct cgacaagctc tgtaaaggtc tgtaacatct 5220 aggccttgac attctgctgg aagtgtggta tataacctt aaggtgtccg gggttgctct 5280 tatacctata ggatacctta gggtctacct ttatctctta cttattattt gaggtatcaa 5340 atactcaaga tgtatacccg gactatgctg gtggctatcc cctgtgggt tctttacctc 5400 ctcgtcctc cctacctgat gacctcggat tcaacctcgg ctagcgccct gggtgcggt 5460 ctgatggttg catccatctt ctatgggctc ttcttcttga agtacctgta caactacagt 5520. aagcggctgg agaaaaaggt caagactttg ggggtggga atgggtgagt cgaaggaacc 5580. tatcgtcagc ttcgagaagt tcatgcaggt catgtatgac cgagacgagt acgccaagcg cctggagta gcaacggcca agatcgagga gctggagag tccttggcaa tggcactcga cgcagcagcg aagggtgatg atgctcgcca tcagtgcggc ggaatggaga tggagatcca 5760 ggaacttcgt gatgaattgg caggactgaa aaatgaagta aaggcgagta agcctcagca tgtcacccct catttctggc gacaacgggg gggtggtcga atctttgtgt caggtaactt 5880. taacctggac accgagacga tacccttcat ctgcctggag actggccaaa gctgggacat tcaggagggg cgggtaggt atatcttcga gttactcccc aagggccata ccttcacggt ggaggtctga tgtactatga cgaacagcaa tggggaccgc acccaagggc gccgccggtg ttaccgtacc agtgaggtaa cttcggacat atatgacgcg atctacaata tcccagcaat cgctggatcc cccaagaggc caccggatga tgattgggta tactacctcc tgatggtagt 6180. cctcttcatc agcttgtgca tggccttcct tactcccctc atcaccagca aggatacagc 6240 ctattaaagc caaagtcttc tacgagcgac tgaaaacctc cggcgagctg accctgaatg 6300 gcggcatcta caaggccacc aaggttcctg cgccccacaa gggtaagcag cagcgtcgcg 6360 gccccttcta agaggtcgct agtaataccc ctagtattcc tgtcctgggg gtattgctgg 6420 ataactcaac aaaggagaaa acaaatggca cgtatcaagt acgccttcgg tatgaagtcc 6480 aagaatggcg aggataaagc cctcaaggtg atgacctcta cctcctgctt cggtacaatg 6540 gaaggtccgg taacccacgg ctataagctc gacggttgga ccttcatctg ctcccgccga 6600 agcaagaagt tcatcgatgt actcaacaag tgtacccaag gtgaactcaa gaccatcacc 6660 atcggaggca aggccttcaa gatcccgaag gtccacttct ggtcttacga aagcaaggcc 6720 aaggattccc ccttcgagaa gtattctaac gggacggaaa tgatttcccc cacccatcac 6780 ggaaaggaag gggtctgcgg tatctacttc aaccccaagg tacacaccct ggattcctgg 6840 taccccatca tgaaattcct cttcaagatg atctccagcg gactcgacta ccaaggtcgt 6900 gaagaggagg ttcacctgaa gcttgctgag aagcatggct tctggaagtc ctacctcgca 6960 atgtccttcc acgggctgat agccaatggc tacaccgggt atccgatctc caactacatg 7020 ttcagtagtg attgggatga tctcaagaag ggagatatcc acatccaatc cgctgacgag 7080 tctatccgat tcggtcgttg gatgcccaat cgggatgccc caggtggacg cgagtgggta 7140 aggggcacac cctggcggtc tgaattcctg aagattcagt tggacaaggt ggaggtggtt 7200 accatagccc ctcagccaac cgtcttcgga aagaaagatc cctacatgac cgtagatagc 7260 gaggtgggag ggttcctacg gcttactccc actagctgtg aaaaacacgg agtggtaatg 7320 ctggggatta tgggtgaaat taactggggt cgtgacataa aggatatctt actggccctc 7380 gaagacttca tcgagaaaaa cttctgacaa ccaaggagaa atcaaatggg aatgtatgca 7440 gcccataatg tgtactatga cgccgagggc tctatttgtac accaatactc ggtcaagagc 7500 atgaccgaat atacaaactg cttcggagcc tattgcgacc ggacctccgg cgttagtggc 7560 gaccggtggg ttaccggggt tggccacctg ctggtatcta cccacgagaa tacctctggt 7620 aaactggtgg agttcttgaa cagcgatctg gtcaacagga ttaccgacgg tggtattctc 7680 tcggcttcca tcgactggcc tacccgttgg tgggattaca acgatgacct caagaaccta 7740 agtgatcccg accactttc tcccccagga cgccggcagg cagtgtatgt acgggtggac 7800 ctcaggaa acgcatcggc catcatctgt gccctccgaa tgggcgatcg cttgtggtgt 7860 gtaggtgatt ccatgcgtcg ctatacccag gaaaaccggg ataaggtcct gggatgcaat 7920 gcagagatcc tcaccctcgc ggcttgtgcc caggtaggta gcactgctca ctgcgacagc 7980 tatcctgcca tgttcccggt gactgccggt gaataccggg areatgcga gagtcacgga 8040 tgggaagtgt atgacagcta catcagcgaa gtcatggatg gtatcgtagg tgggtacaag 8100 gagatcacct acttcgatat caagagcatc catgggcgga ctcgcgaaga gttcaaggac 8160 8220 gaatgcgacg ggctcgaagg tgtacacaat gatcggatcc tctccatcat ggcacctatc 8280 actatcgacg taggtgacca aggtcgggaa aggtctgaga ccgtacccac cagtccctac 8340 agcatccccg aaatcctcga aaaactggag actatgcaat gaacaacgca atccccctga tcggtgcaga tcccgaagtt ttcgtcggct acgaccgtaa cccccagagc gtcatcggct 8460 tcatcggtgg accumulator gcccccttgg ctgtagccgg tggtgccgtc accumulator 8520 acgttcttct ggagtacaac atcgacccgg ccagcacca ggagagttc gtgaagcgta tcgtttccgt tcgactcctg ggtgcccaga tgctccaccc cttcggcatg aacatcatcg 8640 agaacctgtc ctctcacctg tacgacgagg aactcctccg cagcttcggt ccccaggctt 8700 acgtcttcgg ttgcgagccg gactacaact gctggactcg tcgtcagaac gtgatgccga 8760 aggatgcccc tccgaccctg cgcactgctg gcggccacgt ccatatcggc ttcagccaca 8820 tcgagcgagt taccaaggct accacccgcg aggtcatgca gatgtgtgac tacctcctgg gcctggcctc tgtcatcctc gatggtgaca cccagcgtaa gaagctgtac ggcaaggctg 8940 gcgcaatgcg ctataagccc tacggcggcg taccgtag cctgtcgaac ttctggatct tctctgtaga cctgaccgag tgggtctatg aaatggcagt acgggcttac acctccaagc 9060 acctcctgga ggagtacaag tccatcgtat ctggcgatga agtccagcga atcatcaacg 9120 agaacgacgg cgccgcggcg gtagctgcac ttaaagcgct gggggtggta tatgaatgac 9180 ctgaataatc gccatcggtt ggccggggac ttcaacatgt actactctc cacctatgcc 9240 ttcttccggg tggacggaga gcctcgggta gtgtacgtgg acgataccga gtccattggt 9300 gacgaccgtc aattcgacgg gtttcgtctc cttggcaacg tgtatcgccc cgacggcagt 9360 aactactacg gaggggttgt ctacagcgag gtagaaagcg tgcggccctc cagtgggtac 9420 tatgacgtct ttggtcgtgg ggttcgtgat acctatgtat ccttctcctgt gaacaaccgt 9480 acccagcgca agggtgtaga tccccggaac atcttgctga atcatggcca acaggctatc 9540 accggcgaaa tgatgatccg aatcttcacc caggccgagg aaatgatctc tgctccctcc 9600 caccgggact tcttcatcaa ggatggggtt gtccactgga agggcgtgaa ggtcggccag 9660 atggtggatg ggcggctgtc cgcagatgaa caattcaaga accaggagga cttgctatgt 9720 cagttatgg cacacagata gggttccata agaaccagat catcgccccg gaacaccacg 9780 aggaacttcc tgcggttgct tccttcgggt tcgaagtcga actggaaggc ctcaacaact ggccagaagt ggatgggtgg gatctgaagg gtgacggctc tctgcgggggg ggtatggagt atgtcttctc cggtcccgcc tctggccaga gggcaatcac tcggttga tcctttgtaa gtgcgatgga agaaacccct ccggctccta ccttccgatg ctccacccac ctgcacatgg 10020 atatgcggga cgtaggtgg ccggtgtacg aacgaacggt cctgacttac atggcattcg aggatgtttt cttcgatcac tgccagccat atcgtcggga tagtaacttc tgcatcccgt 10140 tcttcagcaa cgactggttg gcccagacct tcggtcgccg tatcctggcc ccggaaggtg accgagaga agtcttgggt cttacctcct ggcccaagta ttcggccttg aacctccagg 10260. 10320. cttcgggtcc atcgagttcc gtggtgctca cgccctgact actcgacagg aaatggtagg cctgatgcag cgtatgttgt gtctcaaggc cttcgccatg gctcacgcag 10380 aaacccccct ggaagagttc ctcaaggtgc tctccgaggt gatctccgt gatgtgttct tcctgggggt atctccggac tatgaatgt ctccgggtgg tcgtgaatg gggatcgcca 10500. gtgctactct cgcggtggca accatgggct ttgttcgctc cggggtagat cctctggagg 10560 atgaacagaa ccgtcagcgt cgtctccggg aggagaacg tgagcgtcag agggctttgg 10620 atcgcaggct gcttttggct cgatctacta cctccagact actcgatggt gcagcagagc 10680 ggtacaactt ggcaatggtc ccaggtaccc aggttcgact ggatacggcg attactgcgg 10740 taacttctct gcgtcgtatt ggtcaccaag tgcgtgtacg agaccttctg gaggaccaag 10800 aggctcttca agatgccttc gtactgctca tggataaccc gcagcacctt cagcgccata 10860 ccggggctaac aatcgaacca gatatgtact aaggagaaat acaatgtgtg gattggtagg 10920 cttctgtgcc acaactaacg cgagtgataa cgaaatcgct cttctcaaat ccctcctggc 10980 cgtggatatt atccgtggtg ctcacgccac cggtttggcc aagatcgacc cggttaagaa 11040 cgaggtagga attcacaagc gggcagtaga tgcctacgac ttcctggctg atcctgaaac 11100 caaggagttc ctggacaagg gtcgggctcg catctacatg ggtcacaacc gttacgccac 11160 gatgggcgac aagacggacc atggtaatgc ccaccccttc caggtagacc acatcaccat 11220 ggtacataac ggaaccgtag atacctgggg cctgcacctg ctggacggca atgataagta 11280 caacgtggat tccaacatgc tgtgcgctac cattgccaac cacggtgcca agaagacgtt 11340 cgaggagaag ttctctggtg ctgctgcggt tgtctggtgg gattccaagg aacgtagcct 11400 gaacttcatc cgtaacgagg atcgtcctct gttcatggcg gttaccacca ccgggaccat 11460 cgtatgggca tcggagcctg ggatgctcaa ggttttcctg gagcgaccca atgctaagat 11520 ccgcctgcgt tctcctatcg ctgaactgaa ggccgaagtc ctggtaacta tcccgttcac 11580 ggaggccgga gtgcgaaagg gtgcagaacc ccagaccact ccggtcacgt ttctggacct 11640 cccgattccc gaaagcgaaa ggcaagcagc ggcatggtgg agtcgttacg tcggtgtctc 11700 ggactacgat gactacagcc gaagccaagg cagccaagcg ggaacgaaag gcagccaagc 11760 gggctcgtcg tatggaacgt ctggcgatgc gtacgcaagg aacaccctcc ggatcaacaa 11820 caacctcgac gcagcaggta gcaccttcaa gcaccggcaa ctcgtcacct tcgatgttgt 11880 caagatcgag gcctacgcaa acggcagcga gtacggaact gtcactggaa tcgagcgtga 11940 agaaaacctt ctcatcgaag ctcatggcat caacgtcgcc aaggtccacg gatacaccgt 12000 cctccgaggg agtatctcca atgcctactt catcggccaa gaccgtgatc tcaaggttac 12060 tgtcgaggat ctggcggtaa gctgcctgga cccaaagcat cggccgactc ctggggagac 12120 taccccagtg ttgaggattg gaacgatctc atcggagacg aaatcccatt ctaaacccag 12180 ggttcaagtc ggcggcacct cggggaacac ccctccggcc aacatcacct accccctgaa 12240 ggtgcaaggc cacaccttca acaacgtgca tgtctttcgg gacttcgtgt cccagggatg 12300 tgcatcttgc gggaagatcc caaccgcata tgaccagcgt aatcgtcatc tgacggtata 12360 cgaaggtgcc aagttcactg gtagcctgga tgagtgcgag ttcatctgtg gtgagtgtgt 12420 aatcgaaaat aaataggagg tcaaaatgac ccaagtaacg atgaagcgtc aagtagtgat 12480 ccagatggag accgacgcaa cccgtaagta tcccttctcc cgtgacaccc tggacaagat 12540 ccagtcgatt cgtcgagtca aggagcagga actcaatgat gccaacccgg acgaggaatt 12600 cctggtaccg gccccggtag tcattgcgga agctatcgac cgactcttcg aagactactt 12660 cgagtaaggt agtgcgttag taatagtccc tggccgaccc atgccggttc ctaagatgcg 12720 tacatgggat ctaacttagg attccagggg ctattgctgg cttcactacc ctcaacagaa 12780 acaggagatt tgccatgttc tatatctata aaggtgcccg cccctctgct ggtgctgtag 12840 cccttcgtaa cgccctgggt gctcgaatcc ttcgctccga ggggtctacc tatcggggtc 12900 gtgcgggtac tgcggtaatc aactggggta ccgttggtgc agaggctcac cgactccggg 12960 atattgcccc tgtgttcctc aacgacccgg cagttgttca ccgctgctct aacaagctgg 13020 agttcttccg ccacttcgag gccaatgctc cccacctgat tcctcgttgg accgagcgct 13080 gggaagatgc cttgggtgta ctcaatatct ctggtcgcat gtatgcacgt accgatctga 13140 acggccatag cggtcgtggt atccatctgg tgtgtactgt caacgatgca gaagttgctg 13200 caatcgatgc tctccgtaga cagggccact acccggtaca catctacggt cacacccaca 13260 tcccggatgt tatcaccagg gcacaactgt tcacccaggg aatcgtcggt aagcgtaccg 13320. agtttcgagc ccatgtgatc cgtggggag tagtacttct ccaagtcaag ctccgccgtg ttgccaatga aatggtgacc aacgaaggac aaagcatcgt tcgtaacgta gctggcggct gggtctacgg ggttaacgat gcaatggacc gtgatggtgc tgagcaggct atgtcggcag cggcagaggc tatccaggta gctggactgg acttcggtgc agtagatc atcttccagc 13560 acgccactgg ccggggccttt gtcctggaga tcaacaccgc cccaggtctg gacgctgaag gcagcgccct ggaggcatac gtcaagggct tcagcaaaat cttcgaggag actatctaat ggctgttcgt gttttcgttt atggtactct cctgtcaggt ttgtacaacc actaccttct 13740 ggaaggggcc gagttcatag gcaatgctgt atcctgcgag cggggtctaa tgtactccgc 13800. tggcggcttc cccatcctct ccttcgcctc ccgtgctgac ctcatcgtag gcgaaatctg 13860 gcaactcccc gagggcgag cgggggatga aatgctggag aacctggatg ccctagaggg ttatccgggt tggtatgatc gtaccctcaa ggatttccga atcaatgggg aacgcatcaa ggccctggtg taccatcagg atagccacat ggcgatggat atcgtcaagg atggcgactg 14100. ctggcaaaac ctggcaaaac 14100. ctggcaaaac gcagtagaag tctaccgcga tactccgaat acattcggac accaagagct acatgcccag aagatgcttc tcaaggagat cctgggcctt gtagcttccc agcgacacct ccaagactct atcgaggtct ccaagattcc ggaggcctcg gatagtcccg agaccagcta cggtgggtac tgtgacgaat ccattggcat tcgcttcatg tgggagcgac tgaagaaaat cgaggatcgt cttcgggaac tggaggaggt ctacggtacc ttcgtaacaa ctccttataa aaccctaccg ggcaacgtga atgctgtacc aagcctggtt ctcaagagtc aactggaggg gtaagtgaag aagatcatcg gtgatacggc ttgtccgggt tgccgagcta aaggtgggga taaaacagga 14520 aatcacctca tcttgttcgt tgatacagaa aagggtactc ggttcggaag ttgtaaccgt tgtggtcact acgaagtcct cgaagagggt ttcaaggtgc cagagcgtaa ggagaaatcc 14640. tgtggtcact gaggaggata tcatccatga agtcaacgaa gtccttgagt atccaattaa agccctcgat 14700 actcgaaaga tcagcaaatc aatcgctgaa cggtacgggg tacgtgttgg tctatcacaa 14760 gagaatggtg aggacgttat cgagcattac tatccacgca ctcgcgaagg ggagtaccga 14820 gcgttcaacg tccgaatcct agaacctaag gctttctact accgtggaag ccccaagggc 14880 ggtgtagacc ccttcgggta taacaccctt cggcataagg atatgggaca cctgcggtta 14940 gtcatctgcg aagatgaact gtcggctatg tctgtggccc agatcatgga gtcgaaactc 15000 ccggagaagt ggaagcatct tcgtcaggca tccattagct ggtcctcggg tgttggttct 15060 gctggacggg acattgcgtt ccttaaggag tctggtgtac ttgagcggtt caacgaggtc 15120 atctattgcc acgatgcgga cgacgaaggc cgtaaatcag tagaaaaggt acgtgccctg 15180 taccccgagt gtaagtttgt cgagctcccg ctgaaggatg ctaacgacat gctcatgcgt 15240 aatcgggggg atgaggttta ccagatgata cgtttcggca gcaaggtcaa gtctccggac 15300 tgttccgtta ctgtcgatga ggtatacgct gaggctctgg aaccccccaa gtggggcaag 15360 agttacccgt gggaaggttt aaccaaccta acctatggtc agcgggatgg tgaaatcatc 15420 ggggtaggcg gtggtactgg tatcggtaag accctgttgg cccacgagat tgctgcctgg 15480 15540 accccttaaga atatcgcggg gaaggttgcc aacgtgccct tccaccgacc ggatatcgag 15600 tgggatgagc aagcctttaa agatgctgct ggtaaactcc gtggcaaact cttcatgtgg 15660 aagaaagg gtcagaacga ttgggatcat atcaaggagt gtattcgctt ctgggctgta 15720 gccatggatg tgaagactat ccttctggat aacatgaccg ccatgaccaa ccaccttagt 15780 ccttctgaaa tgaacacgga gatagcccgt atctgtacag aactcgcagg gatggccgac 15840 gagctaggac tgcggatctt catcttctcc caccttaacc cacccaaggg taaccgtacc 15900 cacgagagg gcgctgaagt aaaggaaagc cagttcactg gttcccgagc tatgcagcgg 15960 tggtgtcagc ttatgatcgg cttcgagcgg aacaagcagg ctgacggga agaagcac 16020 gagagtcgaa tccgtgtaat caaggacagg aactacggta acactggcct agtgttcacc 16080 aagtataacc ctgagacggg tcgcttggtt gagcgcgagg gcagttacga cgaggtacct 16140 gctgacgatg acaccccaat ttgattacgt gatctatgac cttgaggggg acggcctctt 16200 caatacggtc acaaggcttt ggtgcgctgt tgttgtagac attccgactg gggtagtccg 16260 gggattccgg cccgaggaaa tggatgtgtt ctacaggatc atcgcccatg caaagttcgt 16320 agtcggtcac aacatccttg actacgacaa ccgggtcctt gagaaacttc atgggattat 16380 cataccccca gatcgaagct acgacacctt ggttgcatcg aggttgactt ggccagaccg 16440 accccagggt cattccctgg gtgcctgggg tagattcctg aagtgtcaca agggtgattt 16500 taacgacttc tccaagttct cagaagaaat gtttgagtat tgccttcagg atggagtggt 16560 cagtcacgca ctgttcaact acctcctccg ggtactcggc atgacttggc aagagcttgt 16620 tgaatggagg actgtagatt ggctaaaaag cgagtgagga actacaagcg tgaaagggaa 16680 ctggctattc gacgcggcga aacgggcgtt gggtctaagt ctggagatgc tcagcggcac 16740 cgagcccgcc gaaaggtgga aaagcgtctt ggaaggaaac tcggagccga cgaggttgtc 16800 gatcatatca aacgtgttaa agatggtggc ggtaacgggg attctaatct ccgcgtccgt 16860 agtcattctt ctaacgctgc tgatggtggt cgtgtgggca atcgtaaggc caaaggcatt 16920 cgtaagaaaa agtaactaag gaggggcctt cgggcccccg aggactctct atgttcaatc 16980 gaaagcttag catcagtaac atcctcagtt ccttcgataa ggttctggtg aacctgaaga 17040 ccttcatcca agagtcttcg gaggaatctg agcgcatcta caacgagatc agcctgctca 17100 aagctgagcg tacccaggtc atgcaggaca acctgaaggc ccagaaggta ctggctaatc 17160 tcgaagagct tctgggaggt aagaatgaag aagtatcggg ttaacgtggg gttccaggac 17220 accaaggtgt tcactgcgga cttctatcga atagaactgg atatcattcg gttctactcg 17280 ggtgattctg atgccaaccc attgaccgtc cgggcctatg aggttggggc tgtccgtgga 17340 tgggtttctg tggaggagat taacgatgga gagtaagaag gaaagcctgg aggatcaggc 17400 acggaaggag attgccctgg agaaggagtt ctctggtagc tggggtggcc ccgagatcga 17460 tgctgatgac ttccccttgg gtagtgcctg tggcctagat cccgaggtct gcgagtcatg 17520 cagctgagtc agtgcgcatc atagcaggag atatctggtg agtatcctag cgcaagtgct 17580 tgtcatcttc tggagtgcat tcttccaggt attcctcctg ggattgaact ctaagctgct 17640 ccgggatgac aagatcaagg ctgggttcgt agtgtcttgg tgtatcacgc tggctcagtt 17700 tgcttacatc aaggcggtag cctcctccca cttggatatc ggatggttta tcttcgtgtc 17760 cgggtgggga ggtgctattg ggattacctc tgctcaatac ttctacaagt ggtatgacag 17820 agttttccac agatagtctt gacaaatcca gcaaagtgtg atataataac cttaaggtgc 17880 cgggggttgc tttaccccta taggagatac aaatgagtga ccatgtaagc tactccaaac 17940 atgtccgtgg taagtacctg tgtaatatgg cttctgccct acataagagc atggaggtac 18000 aaaggactaa catccggaag ttcctcagca gtccccacat taccctacgg gagaagcgtc 18060 gggtgttcct gagcctgcca gagggattcc tggggtgag ctacttcaca ggctctcatc 18120 ttaacctgag ttcctactcg gatcgtcgaa acgcccggat tcgtgacaag gatatgagcc 18180 tctacgatga cttctacgtg gacaggggcg cccagctgga ccctcgggat gtcctgctta 18240 cctcccaaga gggaagaag tggggttttc aattccttaa gaagaggcgg ggtggtgtct 18300 tcaacctgtc cgacgaagag ttgagcgatg ccaaggatat ccagcgcaag cttgacctgt 18360 cctggtacct ggtggacctt gcctgtgagc gtgggtgttc ctacttcatt ttcgactggt 18420 gataacatga gcaagatcaa gagtgttctc atggagcgggg tagatgactt cctgctcaag 18480 caagttgctg tagcgttctt ggaagacaa tggcgactgg accgaagcgg aaccgtggac 18540 tacctctcct acctggaggg tatctccgac gaggcagtgg aggtagtcat agagaatctg 18600 gcggagcgtc ttaagggga ttaagtggat tggagaaagt cactgttcgt tgagcacaag 18660 gtagctgata tcatcagtcg ccagagtaaa cgtggagtcc acttcaagac tcagcgggcc 18720 aagtggctga tccatgtgct taccgaacga atcctcaaga ttgaccttga ggccgtcccc 18780 cagatgccga tgatgatcgt aaaggctggg gccttcagca agccattcct aaagagtggt 18840 aagccgaacc aaaggctcca gtccttatgg caacgtcttg ggcacttgga ggtatctgga 18900 ccattcactg caatcgagta catacccttc gaccttggta agactgccaa gttcaaggat 18960 tggatgctgg atcagggatg ggttcctgac caatggaaca tcaaggatat tactgtcggc 19020 actgatggca agaagctacg tggatccgac cttaatgaat ccttgaacaa gtacattgaa 19080 gacctccgac aggataatc tggacgactc cgaatgaagc tccagggtat catccctggt 19140 aagactacaa tcggagaggt caagagaaag ctagaaaggc aacgaaaggt actaacgact 19200 cctaagatga ctgaagagtc gatggatacc gtccagggag acctgggaaa gctggtgatg 19260 cagcgaatgg tttgggccca ccgtcggtcc ctcttgcagg ggctggtaga tcaggtgagg 19320 cccgatggac gcctagaggg gagtgctaac ccctgtgcaa cacctacggg ccgtatgagg 19380 caccgtgtag tagttaatat ccccgctgct cgttctccct ttggaccaga aatccgaggg 19440 ttgttccagg ggacacctga tgccggtga tggaatga ctgtcctccg ccgagacatt 19500 ggagagaacg aaagggttag gccctcact aacatcgtgg aggaactca gaaggtaag 19560 tggaagcctg taggaagca caatatac gtcccagcga atcaatgat ctcgtgggc 19620 tatgatggtg ctggactaga gcttcggatg cttgcatcct acatcaataa cccagagtac 19680 accaaagagg tggtcgagggg tgatgtacac acggccaacc agatagccgc agggctcccca 19740 acccgtgacg atgctaagac cttcatctgt gagatatgga tgacttgggg gaaacccctc 19800 gattaaact gggtgaactc agggaccct ttatatggg aatcctgagc cacacactt 19860 gatattccc gtagaatgtg ttatactgat atttttggg aggtgtttat gaagtaccca 19920 aatggatggt ttaagattaa gaacgtaga aagtgctcct cggagttcca gcctactgcc 19980 cctagccacc actactgctc agacgagtgc aaggagtggg gtaggatca tgcctactac 20040 accagagtct atggactcac gtatgatgaa gtaagggcta tggctgatga acgagaccac 20100 aagtgtgata tctgcgggga gaagggattc ctgatggact cctctaagca cattgcattc 20160 ttagtcgttg accactgcca tgcaactggt aaggttcgtg gactcttgtg tcacaactgt 20220 aacagagcat tgggactgat gaaagattct ccagagcttc ttcggaaggc tgctgagtat 20280 cttcaagtgt aaggtgcaga gactattatg taggacccaa gcgggttcga agcgcccagc 20340 ccctggaaga cagggtgatg atatagtccg atccccaggg gaaaccttgg ggcagccgag 20400 aggcgggcca gtagtagcga cactggttga acttttgatg cgttcatcta cggtgctggg 20460 gatgccaaga tcgggactat cattggaggc accagggcag acggggctag gctccgggcc 20520 cagttccttg aggctaaccc tgatcttgct gcattgattg agagggttaa gcaggaagcc 20580 gagagaggtt atctcgaagg gctagacgga cggaagctaa ccatgcgacg ttctgagtct 20640 ggcgacgtga tgatccataa ggcattgaac accctcctac aagcggcagg tgcaattgtc 20700 atgaagtggg ccatggtgct cctagatgaa cgggtccgga ggttgaacct tcgggcttgg 20760 aaagtcctgg atatccatga cgaaggtcag tgggaatgcc acccagagga tctcattgcg 20820 ctacgtggac agatggaaat ctgtgtccgg gatgctggag ttctccttgg ggttaactgt 20880 cctttggcta gtgattccat cgctggtcgc tcgtggtatg acacacactg atacatctgg 20940 gggttgactt tcagccccct ttgtggtata ataccttctt ccctacgaga ggtttaagat 21000 atgtctaaga aagtatccca acgattcacc ttcccggtag cgaagctgat cttcccctac 21060 atcgtaactc cggacaccga gtacggtgaa gtctaccaag taaccatctg cattccgacc 21120 aaggaagagg ccgacaatct ggtacagcag atggagtcca aggatgcccg actgaagggt 21180 accatcaagt accaagagcg tgacggagag tacctgttca aggtcaagca gaagaagcac 21240 gtggattgga tgcaagacgg tgagcgcaaa tctgccgtga tgaagccggt ggttctgacc 21300 tcggacaaca agccgtatga tggccccaat ccgtggggtg gctctactgg tgaagttggc 21360 atcctgatcg agacccaaaa gggcccacga ggcaagggta ctatgacggc cctgcggctg 21420 cgcggtgtac gactccacga gatcgtatcc ggtggtgacg gtgaggacga tccgctgttc 21480 ggtggtgcct tcaccgagga agagcccgag gatgtattcg acgaggtgtt cgatgacgaa 21540 gacgctccta tctaaggggt tgggggatca cgaggcgggg gtatgcccac ggggctgccc 21600 ctactgctta atcgaattcg aaagagtgtg gggtgtaagg gtggtcagtt ctacagctgc 21660 atctaataat aaagtagagg tcgatcctaa tggaatcaag ccgggtgagc cgggcgctaa 21720 acttgatagc ggcaaggtgg atgttggaat catcttcgaa gcgttcccga gggctctata 21780 tgcagtggca caagttgcta acttcggagc cagcaagtat agtcgcgggg gttggaggtc 21840 tgtcgagaac ggagtccagc gatatgatgc tgccttcggg agacacctcc ttgagcgaca 21900 caagggtgag gctttggacc cccaaagtaa actaccccac cgataccacg aagtgtggaa 21960 cgctctagca tccctggaac tagtcattca gcaagaggag gactccaatg gaacttctgt 22020 tggatccaag ggctaagact gttcctagca actactctgt aaaaggcgtt gatgtagacc 22080 tggggcttcc cccaggctac agcctaacgg aggaagctat ggacaaggcc aagcgtcaag 22140 agagtgaata ttacgactgg aagggctacg aagcactggt taatccggtg gtagagcacc 22200 cagagtatcg agccaagggt gaagcctttg ccctccgtgt attctgggaa gagaagctca 22260 aagagtctca ggtcgtagaa gaggtaacgt aatgattgct ggtatcgatg gtgacgttct 22320 taggtatgag ctaggccacg tggctatgtc gaaggaacac atcttcgata tccaggtgga 22380 gaagccatgg cctgaggaag aagtccacaa gctcgtcgat gataaagtcg aacaaattat 22440 caaaagggtg aatgcagatg agtgtgaaat ctaccttact ggccaaggaa attttaggct 22500 ggagcttgcg aaaatcaagc aatataaggg tactcgaatc ggtcttgaaa agcctcatca 22560 ctgggaaacc gtgtcagcca gacttaagga caagtgggga gcaatcactt tccacggtat 22620 cgaggctgat gactggctcg ggattcgagg gactgaagag ggagataact ttacagcgtg 22680 ttctagagac aaggatatcc gccaagtccc aggatgctac cattacagtt ggccctgtgg 22740 agattcccag ccggagttgg gaccgtttca agttgatggt cttggaagag tctccgcttc 22800 ttggagaatg tatggcgtta aaaagccgca gaaatcatgg aagcttgagg gcaacggtac 22860 ggcattcctc tacgggcaac tccttgttgg tgactctgtg gataacatac caggcctccc 22920 agggacggga ccaaagacag cggcagattt gcttggggag ctttctagtg agagagatct 22980 cttcgcagct tgcgcttacg cctaccaaca gaagtacgga gataattgga aagagtacct 23040 tctggagaat tttcgtctcc tctacctcat tcgggaccgc tcttggcttg atattcagca 23100 gtccggtaac gagtatcact gctcactgaa gaaacattgg gagattccct atgacgatga 23160 agaaatattc tattgaggaa gcacagaaaa tctgtgaagg cctctttgag atccttgagg 23220 gtcttaactt tactgactac aaggtcgctg gtggtttcct tcgggatgca gacaacgggg 23280 ttgcacccaa ggatatcgac ctgtatgtcc gtaggcccta tgtggaggac cccactgata 23340 ctcggcgtag tcgctttggc ccacggttga tcccctgtga tgacgatacc ctagaggtag 23400 aggtcactcg gttctacaat aagctgggcc acaagaaagt ccggtgtagg actggggata 23460 agcctgatgg gtatcctgcg gggtttgatg tgtgggaatc cattggtgtt gacctacccg 23520 tcaaccttgt cgtgagtact cactcccatc cagcagagtt cgatgtagga ctgtgtgaga 23580 ttgcatgctg gcccataagt atccgtggac tgaaatctca aatctaccgt tcaagggctt 23640 atgagtttga taaagaagag aagtgcatta ctcttaaccg agtcctagac cctcttctgg 23700 atcattctca acccctaact gacaatcaag ttgaaaaggt tgtctctcat atccaacgta 23760 tcaaactgaa gtatccggag ttccgggtgt gcctggggga ttggatctgg cttctggttc 23820 gggctaattc tatcctgact gaagggacac tctcggttat ctggaagctt caagaaggag 23880 ggctcattgg caaagcaggg gagattcttc agacccaaac tgaagtcatt gattgggacg 23940 aagtacgaca gcgaaaccga gaagatcgtc cacgagacga tgccctggat gcagttcaag 24000 ccagacccgg tgagctacgt catacagcac aagtacaagc ccgacttcaa ggtatcgacc 24060 tcacaacctt gtggatcgac gaagcacctg ctggtcgagg tcaaggggta cttccaggaa 24120 gcctcggagg catctaagta catctgggtg agggaggctc tccccccaga tactgaactt 24180 gtgtttatct tcgagcgtcc taacacagct tgccattggc ttagtaagcg taaagatggc 24240 acaaagcaat ccatggcgga atgggccgaa cgtaatggct tccgctggtt tactctagag 24300 actttcaagg agtccttccc taatgagtaa gaagtataat gaagacactc tcgtcattgc 24360 ggacacccaa gttcgatccg aggtcaacat cgatcacctc gggaaccttg gggagtggat 24420 cgcacgtaac cgccccaagc gaattgttca tattggggac cattgggaca tgcccagtct 24480 gtcaagctac gaccgtggta ccgctaagat cgaaggccgc cgagtcctcg ctgacataca 24540 agctggtaat gatgcgatgc gagttctgct cgaccctctt cgccgcctac agcaacacca 24600 agcgggttgt aagaagcgta tctaccgacc agaaatgcac ttcttcatcg gaaaccacga 24660 ggagcgtatc aagcggtatg aaaattctaa ccctgctctc caaggtttta ttgggtacga 24720 tcattttgat ctgtccgatt ggattgtcca tgatttcctc gacgtgggtg ttatcgaagg 24780 tgtcgccttc gcccactact tctacaatcc caacagtggt cggccatacg gcgggagtgc 24840 cgagcatcgc ctcaataaga tcaagcgcag cttcgtccaa ggccacgaac agggattcaa 24900 gtaccacatc gaggcagtag gcaagaagcg aatccacggg cttgtagtcg gtagcttcta 24960 25020. cctcacgat gagtcctaca aagggcccca gggtaacgac cactggcgag gtgtagccct cctccggaac cacaaggacg gagagtatga cctcaagctg atgagtgtgg aggagttcct gtgagtaagt tcttgccaga cctgtactac attaagtctg agcatgactt cggtcaacgg gggttggcgt ttaagacgcc gatctccgca gaactctggc tggatatgaa gtttgggaaa ggtggtgctg aggatgggct tagacgaggg atgtattcca tcgaagtcct ggagatcctc 25260. tacatcccca gcgttcacct tccggatatc ttggggtaat ctatgaaaga tcgagtggga cgtaagctag aggtaggga cagtgtagtc ttcctggtcc acaggaacac ctcctcccat ctagccattg gcaccgtcga tgggtttacc cccaagatga ttcggatcaa atgcccgacc 25440. atgagttgga ctattgacgc tgagtatgtt ctaagaagca gtgacaaggt ggtgtactat gacaaaggct gaactggaga aagcacttga agagacgcaa agcgctcttg cgaaggctga ggcgaaggcc ttttccttttg aagaactggc tgaagaagct aaaagacaga ttgaattcct cgaagggatg ctagacctag tagccttag ggcttctgta ttctacggag attggagggg 25680 ttatgcagaa agatcaaaag ggtaagggtg gattcccttg gacctacatt gcggtagcag 25740 ccttgtttgc cctgctggtt tatgtaggat atagctgact gatgttactc ctgaccctgg 25800 gagaaattc cagactcctc atcgatgtat tatcttgggc aggttcactg taggtatcca 25860 tcgagtaacc aaaaaaagg ccccaagggt atcatcccaa ggggccttat ctttagctcc 25920 gtagagcgtt cagcagtgtg ttgaacttat caacgagtgc ctcgtgagta tccgtatagg 25980 aagccacggg gatctcaact accttaccct tgacgtaagc cgcaatggct gcatctaggc 26040 cactcacttc gctagccttg ggtttccagt tacctggttt agcctcgcta gccttagcac 26100 ctacctccag aagctcaggc ttcccctcaa tatcctccca tttcactggc tcaaagtctt 26160 tcgggccaat gacttgtcga agggtcccat cttcattacg tacagcaata gccttcgatt 26220 gaataacgaa tacactgttg ccgtcgttgt cagcgatata acctgccata atctaactcc 26280 taattaaact gccgatttga aggtacccac ggtaccaccg aaaggataca ctcggacagt 26340 gcattcccca aattgaccat cagtctccgt ctgattaccc ttagcatacc aagccttgtc 26400 cggagataca gcgaacttga tcttagctgt agacccttgg ataaagtgga agtgacaacc 26460 tggggttaca tccggaccaa gagtaacggt aatatccgta gtcccctggg acatgaagaa 26520 ccaaccagac tgctgcttag taagggtaat gttctgggtg agttgctggg tgttgacaac 26580 gttaccaccg aggtgagtag tcaccagtcg gggatccagg tagttctgtt gaagagaacc 26640 aatgttcttc acaggaccac gcatgtcgtc aaactgctcg ataatgtaat ccccgatggt 26700 accaccgttt tggtcatccg ggccaatcac gtgcttaata gccacgtaaa cacccaggtg 26760 ttcccgtcga gggtctactc ggaattcact accgaatgca gtaccgcaag gtgcctcaat 26820 catggtctca gagaacagac caatcacgtg gccagggtca cggttaccac ccgaggtttc 26880 tccaggagca cccacgaggg tattgaccag gacagagggg ataacggcct ctgagggatt 26940 ctccgggaag gaggctgtaa cgttctctac taccagggct gcgttctcct taactgcata 27000 atagtcaggg aggaactctg tagcggtaac gatgttagta tttacccgac cggcatccga 27060 ggtaatctca atgagatcac catcggcatt acgtcggaag acttttggaa catcaaccac 27120 gtaggcacgg ccaccaggac cagcggcatc agtttctaca taagttgcca tattacttct 27180 ccttaaagat ccagagcatc ttccatcgct tccataccgg caacgaaagg acgtgctgga 27240 gtttgcttat acaagaactt ccagatttca cctgcggatg ggtcatcccc aaacgaagcg 27300 atagttttac caacagccat agcaccctca gttgcagcac cagctactgg acccaagact 27360 acctctgcgg gggtagtccc tcgacggtaa cccgtcagca tgtcgtagat catagaagcc 27420 tggagtggca tctgttgcat cactacgtcc atcatccgtt gttctggact acgggtatcc 27480 tctcggctag acccaccgaa cttagccatc tgacggagtt catcctggat gtaacccaga 27540 ctcatcatca gaccaagagt gaaggctaca cctgcggcac ccataccagc gttggtccaa 27600 gaaccagcga agtgtgggct cagtcgtcta cggaacatcg gtaggatgat gttaccatag 27660 gctgctgggt aacccttcaa gagggagaac atctgaacgt ttccgttgct catccacata 27720 ggcttatcag cgaaggtggg gtctaggact acctgatcta caaaccgacg catggccaaa gtcttgacgt tgttagccat caggacttca gatggagtag ccggggagat caacttgagg gcatcctgct ggctaccgat gttaaccccc atttcccgaa gctgagcaac cttcagagca ccattggcag aactgaaagg gagacctgcg gctagatcca tcaggttgtt ctgatagacc cgcttagcag tctctgttgc aaatattcgg ttaacatggg ttaggatgga caagccgttg atgaggaact gaccacggat cgccttttgg atggtaggt taacacctc agcaccacc cgatcagcca tcagagaagt agcagaagcc agggtgtggt tcatatcact cataaaccga ccggtctcag actttggaac cccactgtag atcctgcggg ctgcttgcct tactacctca cccatagttg ggagtacagc cccaagggta ggcataaccc ccgccttagc gaagggtagg 28260. ctgaactcgg tcagggtcga gaaaccggcg agtggaagtc ttgagagcac gagggcaccc gacgtaacag ccgctagctt cttaaggtta gggtctttga tacgaccgtg cataccatta 28440. tagcatcca ccaggtcata catccgatcc acctcttcct tggtaacccg tttaccagcc cgttgagcct cagctacagc agaagcgatc ttagcgttag ccttctctcc gttgatacca aacctttcgg taaggcaat ccggtggga gccccttcga agtagtctcg gatttcctgg agacgcttct taggagtatc attaagagaa tacttattga ggatctcctg aggtacggag ccaaggccc ggctttcttc cagttgacca tacttaggta ctgcatcgct ttgggcgaac cgtccacgta gggtatctgg gtcaccctgg atacgatagc gagggtc ttcccaagcc 28740 ccggtctgct ggttctgagt aaccagtcgg ttaacctcag gggcagtgtt accacgagta tcatccgaga cttctgccag ccagttggct acagcatctt cagcagcttg tcggctctgg aagtacggag tgatatcgtt caggaactct ggggattgaa ccttctcagg ggacagccca aagggcatat agttggggat agtaccaacg gacattccac cacggttaac agcctcattc cttacgtcat ccatcaaagc acggagacgg gtagcttctg gggtattgac acctgcggat 29040 gtatctgaga taatcctgtc gatctctttc gaagacttac cctcgaagat gttatcgagt tcagagttcc acttacctgc ctggagttcc tgatcctcaa agatagtctt accagaggct 29160 cgcttaccac tcatatcagc cctgaaggtc tcagagaact cacgggcgat aggagaagcc 29220 ttagcaagtg gctccaggag ggacgtagct tcgtttccta gggcatccca ggctttcttg 29280 accgtacccc taggctcaag ctcagaagcc ttaggagggg ccgcagggtc gttaggatca 29340 actacggcag acccagctga gtcctgatta cgtcccaggg tgtccaatcc cgaggataca 29400 gcaccaccgg cagtacccat agctgtacca gtgaaggcag ccgtcaggag gttatccatg 29460 aactgctctg gggtttgtac ctgccctact gcatcatacg cgatagtgtc ctggagcgcc 29520 tgctgggcac cagaggtaac accttcagcc acaccagaga ctacagcgtg tttaccagct 29580 tgggttacag cctcaatggc ggtctgctta ggtagacccg attggaccaa catctggtaa 29640 gcgccatctt taccgatgtg cttgaggagt ggggcagcga taacaccagc acccgcagtg 29700 tctagtaccg agaggccagc accaccgagg actgcggtcc atgggttgct ttgatcgggg 29760 tctagttcct tcatctggtt actcagggca cctacgttga tacccatgga actcaggaag 29820 gaaccaatga gcgctccacc catacgacct ggggccccaa agacagagcc agccttagca 29880 cctgcggcac caccagcaag tacaggggcc atcgaaggga gagcctctac aatgttattc 29940 ttaaggaacg acccgatgga tgggatatct tggatatcag cgaaagaccg aacatcaggg 30000 gttccgtact gtgacgcttc ctgagcattc tcctcggcca tctgtgtgcc gtagtctttc 30060 aggtagtcac tgccagtcag ttcaccaagg gtagcaatag taccaccgat gttagactgc 30120 atggtatcaa ccccacgacc aatcgcagag ctaatagaat tagggtcagc cggagttact 30180 agggcactca ggtctggggc aggctcaggg gtagtagggg ctacttcctg gggtgcctct 30240 tcgataacct ctggctcatt caaggaagcc aattcagcgg ctacgtcgag gcccttgacc 30300 tcagccagtt ccgcatcaat agcggccttc agttctggag aaagagccat aagtcacctt 30360 ctagttgctg gaaaagagaat aggctcttaa gatgtatctt aggatactaa ccttcttagt 30420 aagtaagtca aaaggaagaa ggaatcttaa gagcctatag gtctattata ctacattttg 30480 gatactttgt caagtacctt ttatcgggtt ggggcaggat agtccaaatc agcaccaaac 30540 caattacccg taggttgcag cttagcagcc tcccgctgga taatacccac tgggttagcc 30600 cccggattag cccgaagttc atttcggaca gtctgggcaa tagcctgttg ggcagtctta 30660 ctcagcttct taccacccag agcctgagaa ccgttgactt cactcaggat accaagggcg 30720 tccttagtag taacagcttc acctcgggct gccttagctg ccgcttgacg tgcctgagcg 30780 ctgatcttag cagttttgag gcgtacagca gaactaagct gggcattctc ttgagacata 30840 tcctggccac gtcgagtagt ttcagcctgt agctgggccc gttggttagc caggtcttgg 30900 ccacgtcggg tcaactccag attagcccta tctacagcag cctggttgac ccacttatca 30960 aggacgccct cagtcttacg cttggtttgc tcaagggtcc cttccttaac tttcaggttg 31020 ccctccccaa ggcgtacatc agcagcatcc ttagccacct tacgctccag atccttttcc 31080 ttgatctgac gatcagcagc tgcggcagcc atcttctgct ggttgatccc agcctgtagg 31140 ttacgatcca gttgacgctc ataggaagca gcgaacatat ccccggcttt accagtcttg 31200 tctagggccg aagccagaag accagtacca atgagagcgt aagatacata acgagacagg 31260 tcatcattat ccatagtcct catctgggtc aactcttcgt tcaccccggtt cttaagctct 31320 tggggtttaa gctctacacc ttctctctgg gcatcagcct caactacagc ttgggccatt 31380 tcaggacgac ttacagcacc agtacgaaga ccctcggctg caccctgttg gatgacctgg 31440 cgattagcct cctcctcatc tgctacagca gcaccagcct cggaagccac ctctggggtg 31500 atctcaggct cgatagaggg ttggttaggg gttaccccat aggacaacag accggccccc 31560 gtagggcctc ctgtggcgtt ctgggctgca cgttggccta caccctgggc ccattggtta 31620 gcctcttgag caacctcggg acccatgttc tcaaccgctt ggctagcctg agccatttct 31680 tctgcacgag tacgctctgc atccccgagt tctcctgggg ttacagcggc ttgtacacct 31740 acagagatag gaccaccgag gatacctgcg atacgaccca aggcaccgcg accagtagct 31800 tcagccgcag gtgcaacctc ttgggctgca cgggaccaac gctctgggtt ctccagggct 31860 gcctgagcag cacgacggac acgatcagga atacctgagc cctctacagc cagcggcagt ttgttccttg cgattcgcgc catgtccagt tcattctgag cagcccggag gatgctaggg 31980 cgaattgggg acccttcata agccatgctg gccataggat taacctccaa atagtttact tagttcca gactttggct gctgtccgaa accgagttct tctgcgctag gaaggattcc cactcccgct cccatacctg ctgcaacttc cgctgcgcct cgttcgcttg ctcctctagc 32160 cccctcgaca gaaaagcttg gtactgtttc tgaagaaggc tcacttcctt gcccgaggag 32220. agccgcgagt gctgctccgc ccattgcgcc aaaagggttt gattgtccac tagactctcc 32280 cgattgcatt gtcccaaggt gggtggggcg gtaggaacct tgacggctca actgtacccg 32340. ctcctgccca ccacctatat tctgtcctat agcgaacagc ttctgaggaa gggaggccat 32460. ggcccccgac cctaccacca gcattcatac cacagaagc acccgctggg ccaccgaga gagcaccca ggagcac ccgagagcac ccagggcaga cccgaggcca ccaccaccgc caccacccga agaagtagtg acattggttc cccccatatc gccggagata 32580. agctccttat aggcgaggag gtcgttgagg ctgacgttat tctcataggc ccacttctgt 32640 agagccccgt tgatttcctg ctgctcctgg ttctgaagca tgctaccagc atctacctgc 32700 atggcattac cagagccgag gcccttagca atagccgaca ggttacccag ggtattcaac 32760 ctattctggt tgtaagcctg ctggtcttgg aaagccaact gggaagcgtt attctgttga 32820 ttctgaagca gcctagcggt agcaataccc tcggctacac ccgctcggga actaccatac 32880 tgaccagcgt tggttgctcc tgcccgcagg tctggacgta ccgtagtgtc gaagtcccat 32940 tgcatctgtt cgttggctgc accaatggca ttcgccaagc cagttttgtt gggatcgtaa 33000 ggaccaaggt aatcagccag agagctaaca cctgagctac ccaggagaga ctgaagggca 33060 cccccgagac cacccagccc ttcgattcca ctaagctgga gagcattttg gtcagccacc 33120 gggtcaaagt tcggatcgcc cccgtaattg gggtcaaagc ccccgttatg tagccaatca 33180 ctggcacccg agagtagttc attatagtta ccttgctgat agggtgtgga cactgaggtg 33240 gtcttttgct tcttactacc acccttgtaa gcccgagaat ctagagcatc ctctacacca 33300 aacccatca ggcgttttac gttaaattgg aggagttca tctggagtta cctcacgata 33360 gaaggatacg gagtcttcgg tgtacccgag ttctctagg gtaggctcc agccccgacg 33420 accttcgcat tggataacc gataac tcgttggcg aactgtccga ggaagtcgtc 33480 tacctccgag taatctaccg gggtttcatt cccaggcatc ttcccactcc agagaagtg 33540 taggatgttg cccaaggggg cctgggatac ttggact cccgcgtacc cactctctc 33600 ctggtagaag acataggcct catattaac cagggaatgc accaagtgct caaagtcccca 33660 gaacttaccc aagtcagtcc tgttaaaagc acgggctagg gctggaacta cggtcgggag 33720 ggagtctata ttctcacgag taatcaatg atcatggag tcaccag ggggaatgtg 33780 aatgtacccc cgaagactgc tccttgggga attccttgga ttagacacg gccattagct 33840 gtgatcttaa acatgcttg gttaaccaca ccagtctgaa tagtagccct gttgagaaca 33900 tcaagactt gatccaacgg aggtgcgtta gggtcagacg gaggtggata agtaatagtg 33960 ctctgcgctg gtatgatgct ggagtaagcc gggataaaca actcagcagg aggccaatac 34020 gcctggggaa gatccaggac agtagctcca ttagtgtagt taccaccaga catgagcatg 34080 gttatccaca cttcatcctt agcagtgttc atcctatagg cacaggtacc catcggctga 34140 tggttgttct gtggggtaaa taggataaaa tcccccggca ggtccttggg tttagtacct 34200 gcgagtctcc attggttatc caagtcgtaa tgatagatgc cggatactgg acctaccact 34260 ccgggggcaa aatactttac agtccctggc ttgagcttct tagggggctc catagagacc 34320 ccccagtagc cgtcagctag gtcattaaga gtctgtccaa ccctaacgaa ttcttcatta 34380 aggaagggca gcagttcctc ctcttcctgt ggtggaatcg aagggctgta cttttgactc 34440 atcgcatacc tgccttcggg gccatttcaa tagtgtatcc gttgaagtac cagtcaccct 34500 ctgaggagaa gtcgaacttc aaggctatgt accggcccac atgtttagtg tcaatcttat 34560 agtcctggcc aatccggtat gggtaggggc ccttccaccg aataccagaa ccttgtacct 34620 gagcattacc aacccagatg ttgcaggtgc cgttacccgt gatatgcggg atgatagcac 34680 tcagtctt catcattcgg tcatccccaa gatagatatc ggatctctca agggtactaa 34740 cgaagttctg cccagagaat gtagagttat taccgaagg gaacaacttc ttatcctgga 34800 aagacgagaa gatcatactg gactttctg gggttataaga gccttcaccc cagaccgaag 34860 tatcggtatc ccaggggttg gggtcgtcat cccagaggtt agacacctta ggatcgatga 34920 tcccgtaggc tccactgaga acgttgggaa ggtctcggat actccaagtg ttttccttcc 34980 agttccagat gatagccctg tcgcagtgct tacctggctt agacctagtg gaagagtagc 35040 ataccacat ttcagtattc acgtggtctg cattacgaa ggtccgttga tagttgtcag 35100 ggttaatatc cgagaagaag aacttacgga cctgagcatc ataacagac tgcttctgca 35160 caccgttgtg gatatacg tcaccgtggc ctactacaa gtggttacca tcgaactcta 35220 ttgcacagtt gggtccgagg atacctacgt cgttaaacag ctgctggaac tggagatga 35280 acaatccacc gatataccgc atggagtata cagagtcttc cttgtagatg atgaaaggt 35340 cacgaagctt cacaccatcc acgatagcac cattggtatc agccaaggtg ttctgaccag 35400 catctttagt gggtccgtt gggtcccaag atgcaggtac accaccagca tcagccgagg 35460 tactccacca gaccatctgt ggcattcta cagagttact tgtagcgtttt aagccaacca 35520 ggaagttctt aaagactta agcccttta aagtagtatt cgctgggaag ttagggagca 35580 ccctaaggt tgattctgac ggtggagat gatgaggagg gttaacccca tcgttagcaa 35640 agattacccc gttgaacgat cctacagacc atctgttagt tatactagca gcgtaggtc 35700 ctggggatac atcgatgat gtagtcccgt cggctagata caaccgttgt tcagaacaca 35760 ggagccaata ggggatgtta ttccggatga aaggaaacat atccagatt ggggcctggg 35820 ctgtatcaaa gataggcgta tggcccagag ccttctgagc cttgccgttc ttaaaccgga 35880 cgttgttccc gaaggaccat ttctccagtg gcaggtcagc gggggcgata tcggtcacaa 35940 tccccgtagg gttcttgacc tctgtctct ctagggccat tgtatacctc agttcttaat 36000 gatgaagaac acagaacaga acggtgggat attack ggcatgttga tctttactgc atggttgtga gtctgacctt gaccagcagg gccagtctca aggttggtat tggctgcgtt 36180. accagagcca cccgtcagag acccgcaga ccggtgaggg tagtagcccc tcgggatctc caagtgtggg tgtgcgatgg gattttgggct agggtaagg cagtcccttc 36240. agtgaaccca tcccatacga tgttagcgct accacctcta gtccctacag cctgggaaga accatcgata ccccaaggga atgcaccaat caggttaggg acggaccc cgttagaggt agtacctacc ccattgcaca acttccaacc tgctgggatc tgagctagtg acccagccca catgataacc atcccaggtt taacatactg ggttgtatca gcgactgcgt ttagctgggc tgccgttaca gtgacagcct gagaaatatt ggggaaggtg ttcttaatag cactcttaat gagacgcagg tggtcatccc caaaggattt cagatcagag ccggtagggt tcgtaggcac 36660. caactggtta atgtaagttg cgacctcaag acccattctt ggcctccttt atctcttctt tcatttcttt tcgggtgaca taccgctccc caaagattgc catagaaatc tggagatcgc tcaccgcttg ggtgagcttc tccgtggcct ggatgtttct ttcaagcaga gcctgattaa 36780 cattctgacc gacaaccgag gaacctaccg tcactaccga ggatacgacc agggcactga 36840 cgatgctgcc caggttatca gttagaagtt gcatcctccg tcttctcctt aaggttgtct 36900 tccaggactt ttacgaactc gtcgtcaacc ttagagttag tcttctccgc cagagcctta 36960 gcaccagtca cgatggactt agcgattacc ttggttggga agagggtagc cagaaggttg 37020 attgcgaggg tttttagaaa gataggcatc tgaatctcct taacgttcaa tgtctttgat 37080 cgccagtcga gtgctagcga agtcagcggc attctcctcg ttctggagtt ccataacagc 37140 ccgttcgagt ttctgacccc agaactggga ccgagcttca tccatggtgt acagataaat 37200 ctgctcaagg acaccataga gataaatctg cggatacttc gtcagagccc aagtcgttgg 37260 gttagcgagg cttagctctg ggagtacagt ccagtagttc acaatgaacg gggcaccgtc 37320 aggaacaacg gggaatactc gccagaagtt acccaaccga gtgtagtagg ttacaccctg 37380 aggttggtag ttgtagttaa cataatgggt gaaggtatcc tgggtgatgt actgaagagt 37440 acgtccaccg ataagggagt cacccgtgat agatcgtaga gcaacaaagt gctcaggtat 37500 ctcaatgcca ccaccgaagg ccattaggat ttcgaagtgt tcgttctccc tcacccgtag 37560 caatcggtta agacggtcag tggtattacc aatgaacaac atcagaagtt cttgggtaag 37620 atcctgacgg tcagaccact ggatagcggc gatagcgaga tcagttacgt tgttgatcgt 37680 agccattcat tacacccgtg cctcagaggt ccgcatccga tagttatctc ggtcattaag 37740 ccaacgggta aatcttgcgg catggtctgg gtcacaaccg atcaggttaa gatcgatggg 37800 accaccttca gacatggggc gattccgtag ggcctctaca acaaccaggg ggatacttgc 37860 taccttgcgc atattatcct ttcggttact gttgacaccc gagtggcgct cttcggcgtt 37920 agcggacagg attgactcaa catcttgagt atcctttcgg ataaagagcc caaggtcttc 37980 gtcaattgca taagtcgatt ggatactcat gatgtacctc ctaaggggaa acaaagggcc 38040 ccgaagggcc ccgttgggtt agacctgggc tacaacgtcg cggatcagag caccggactt 38100 ctcgttgttt acacgcaggg tgtactcaac cagcagttgg cgcttctcgc tgtcaccggt 38160 cttagccagt tcatgctgga agaacggacg caggtagcag agggcgtgca tcttcggatc 38220 aaagatgaac atggtgtttt cgtggaacca gcggttggca cgaatggtgt acttaccgaa 38280 gtcactctcg tagacgtcca cggtctgcgc aatgcggttg tccgaggcat ccagggtgat 38340 ctcagttgca cgacccttca tgttcttgct gatggccttc ttgatcgagc tcgaagtctg 38400 gatcgagtta gcctgaccac cgttgcgcca gatggcctca gaggcattca ggagcatgtc 38460 ttcggtcaga agacggaggt caccagcggt accagtgtcg gaaccatcac cagttggcag 38520 ggtaccgtta gcacctaccg aaccgttggt cttgtagtag gcaaagatgt ttgccatctg 38580 acccggagta gtggtgttac gctggatctt agcctgaggg gcaccgacca tggcgtattc 38640 catgtccagc ttcagttcct tcgacttctt agccagctga tacgccagtt cgttcttacg 38700 accagccttc ttgaccttat ctgcggtacc ggtgacttgc agggtctcgt ccgagatttg 38760 38820. gcagtagttg ttcaacatgg tggtgaagct accagccttg atggttgcat cctcaccttc cactcgggtg ttcttacccg gctggcggag ttcatcagtc tgccactcgt gggtgatagc 38880 ggtagctacg cccttgccga tagcagtcat gaacggggtg tcatagggtg cgatgttgta 38940. gatgatatcg ataaggtctt cgcgcttacc gttgatctct acagtcgaga cggcattagt tggagttgcc ataagttacg tttccttcta ttagaaaata tcgagagagg agaagagagc agcagcggct tcaaccgact ggtctttcct cagattagcg cgggcagctt taacccgctt agaaccctct gaggcttccg acctacgagc agcaggttta actgcggcag gtagttcagt ctcctccttc ttctctaggg cagccttgcg acggacctga gattcagccc acttacgtgc 39240 tgcatcgagt acagccagtt ggcgggcatc agatatccct cggatctcat cctcggagta 39300 tccaatcgat ttgccgtaag acacgatctt gtcaccccaa gactcatccg tagtcatttc 39420. cgggataagt ttcttggcta gctctgtctg acgcttaacg taggcagagt ggacaatctc ggctcgcttc tcttgcatag ccttaatgtc gttacgacgt ttgataagag cctgggctcg 39480. gtctcgggct tccagggctt ccagtcgaag ggtttgatac ttctctgggt cctgggcctt 39540 aagctgctcc cagtttacat tgtcatactg attagcacca gcaatagcgg taacagcata 39600 ctgctcaagc tcggccagta gattagagcg ttcagcatca agctcttcga atttagctgc 39660 atactgatcc tctagttcag cttgtcgagt tacaaactct tcattgcgaa ggtagccact 39720 cttaagctct tcgaagttaa cctcgtagac ttcatcccca atcgggatct caaagagttt 39780 atcctcagga tcttcctcgg actcaacctc ggggtcttcc tcagaacctt cttctggttc 39840 ctcctcggac tcaacctctt cggtgtcctc tggagtacct tcatctacta cctcttcctc 39900 ctcttcttcc cctacgactt taccatctac ggtttcatca ccgggggcca ggaggtcatc 39960 accgagcaaa tctccgaagg cttccgctgc ctcgaattca tccatgcctt gattctcaag 40020 gtccattact tatactcctt tagagtgatc gaatccagga tagcctgaat acgaagttgt 40080 acgcggttga gggcatgtag ttcgtggtag atggcctccc tggactctga atccttaggt 40140 gccgtggact tccactctcc ctcgatctct tcttggacaa tacggaaaag ctcaggaaga 40200 acgttctcac gtaccatctg ttgtgccgca tcagtcagca ctagactata gccaaaacgt 40260 tctcccaaga ttatttcctc actgccttcg agggcttctt agtctcaggt accttaccgt 40320 ctccgatata agcagcccga gcctgagttg cctcaagatg atactccgct tcgttacgag 40380 cccgttccca agtgaaacga tcacgctcaa gttgtagttc cgcttcctta agggccattt 40440 ctctctgctg aaggacagcc tcttgcttct tcagttcgat ctcagccagt ctgatctgag 40500 cctctacctg cttcatctgg gcctccgctt gcttagccat agcgtccgat tgggcacgtt 40560 gggcatcagc ttgggctttg atatcttcag gcttaggttg tgcttccttc tgctctctga 40620 tggccttagc ccgttgagct tcaggagaat ccgggttagt ccagaagcga tccgggtctt 40680 tgtacccagc gttctctgtg acttccttaa ggatgttgta aagattctgc tcagagacaa 40740 ggaccccgag acctccaccc ccgactacag cctgggccat ttcccagata cgcatcaggt 40800 ggagcatctg ctggtctttg ttcatgttgc caataccaac ggtaaccgtc aggtcggatc 40860 tctctcgcca gttggcaggg ttaatagcaa cccacttgcc tcgtagctgg aagacctctt 40920 cctgattctg gtacttgatg gcatggtcat gcagaagttg gaacaaacgc ttaacaccag 40980 tctctgcaaa catccgggca atcaggtcaa tctgttgctc agcagcagtc atcaactggt 41040 ttacactcat agccgcttgg ttagagtgca gggtgttttg gtctagacct cgggtacggt 41100 cagtgatacc tgtccgctta cctctgtctg cctctagtcg atccagcatc ccatagactt 41160 ccccagacaa ctgaggggtc tccaggggca tgatggaatt catggcctta actcgaacaa 41220 taccagctgc ctcgttggtc agcaagtctt cgaggttcac ctgaccgtcc aagaccacag 41280 atcggccctg gttagtacgg tagatgttat ccatgatgtt ccgcatgaga accgaacgga 41340 tctcttgaat gtctcggatc ttatcgtaga cactcatccc gtggaactta tgggcaattc 41400 gataggcatt caggtcagcg aagggacggc aatcccaagg ctcgttgctg ataatgtagt 41460 caccaacgta caggatacgg cgcaactcag agataccatc cccatctacg tcaagaaggg 41520 tgtagcactc agaggcccat acctcacggt tggctcagc atcatcccca gagttgtact 41580 ggagttggcc agtcatatcg aagttatcac gtaccacct ttctggctga ctatcagaga 41640 attcatactc atcgtatgga agctcatcta gtacatccctc gggaacaccc aagagccgca 41700 gtcacttac ggtatactc tcacggtgac agaggaagcg tgcatcatca atacaggtag 41760 ccaaccgatc aaccaggaag ttctcaggct tgatacaggt gactttaatc tctcgctct 41820 tcttgtcctt gcgaatttta atactgtagg ttccatcctc gtccacactc tgtgctagaa 41880 tctcagtgtc tggatcagcc aggatatccg ctaccattc ctcagagaga ccagagaatc 41940 gttcgaaggt agggttcagg accctcta catagacctt tacacaccg gtcttcatca 42000 tcagagtgtc ttggaccag tcgaacatta ccttgaaccc ctcgttctta cgcatgaaga 42060 ggtagttcac attackcagtc tcttgctg cctgttcac atctcggca gtctgaggtt 42120 catacttaac tacttgaccg cctgacgtga ataccttcat agagaaggc ataatccagt 42180 ctacagtctc ttgaacgtcc ctagatacaa tcgcggactt cccaggggcgc tcgttaccga 42240 agggctctcc gaagtaatac ttcagggcct cagaacgctg cttggaaagt tccgaagagt 42300 tgaaatcaag ggcgtcgtta acaagttggt ctagatgacg aagtacctgt tcatcatcca 42360 taggcttaat cttgcgacga cgcttagcca ttagacaata ctcccaaacc aatcaggggt 42420 caactttgca gtatcactcc tgtagtatcc actgtttcgt acagcaccag gacgtgcatg 42480 ccgggaagcc atcaacaggg cataccgggt agcggagatc atatcgtcgt ttctgtcgat 42540 aatctttccg tcctttcggt ggtacatttt catttctttt aggaagttcg tacacgtatt 42600 aaacaccttc agatcaccat tctccatacg ggtcaacatc cagttaacgc cgaactctac 42660 agagttaccc ccgtgtttac catcaggacc tggggggttg ctgaagggtt cataaacaac 42720 attgaggttg tggtcatcct tcaggaggtc tacgaagcga cgacctgagg tagctccatc 42780 atgcttaaac gcatcgtggg ggactacaac agggatctgg tgaccaccct tgaggtagat 42840 agcatcagcg tgcatgccga gggtttcgcc agattcactt cgttcatcat acaggtaata 42900 cttgtccttc tctgcatccc aggctacaca ggcgatagcg ttagggtggt caaaccctag 42960 gtcgatacct ataatcctgt ggaagtggtc cgggatatca aaaggctcac atacgaactt 43020 ctcttccaga atggggaaga ctacaccaga tccgagcata ggaacaccct cggccctcat 43080 cctgcgttct gctggagagt ataccgagag tagctgctct ttaacttctg gactgaggtg 43140 tggggcgtct tcccagcttg catggacaag gaactgacca ggtttaagat cctggaggaa 43200 gtccttgacg atctccgtca gaccatgctc tggggtaaac gtcagatata caataccccc 43260 agtagtagcc gttcgggtta cacactgggt ataaatatcc ttggggcatt cctcatcgag 43320 ccagatgacg tcgatggcag tacccatgaa tttgtcctgg gacatttcgt aggacttgaa 43380 gataagggac gagaggcccc cggaggcatg cttaacaact actgcttgca cacatccggg 43440 tttaccttcc ctacgaatcg tctctacgat atcttccttg gggatcatcc ccgttccaaa 43500 agcctcaggg ttcttccagt cacctagtag ttcggactga agaatatccc gagtggtatc 43560 cgtggagatc cccgccgccc agcagttcac tggacgatca tactttctac cagtccacca 43620 ctcagggtag cgaccggtga ggtggcaggc catgataaag gccccggtgt aggttttacc 43680 acagcggtta ccagtcatag ccagcaactg ggcgcagttc gaggaagctg cgataaactt 43740 ctcttgccac cataaggag tgtactggtt catgcggaaa tacttctgcc gctccgccaa 43800 ctccctgact agattccgta gccgctcttg ggtatccatt agaccacctt gtcacctact 43860 gttgatgcac gccacagggc ccgttggagg tcccttacgc gcactggagt ttgtttagcc 43920 cagagactat cttctgcctc ccatgcagcc tcgtcaaacc ttccggattt cagaagattc 43980 cacgtcttgg ggaacttctt cgtccacgct gtacccagct ggaagttgac gctaacgagg 44040 gcatcgaata gctctggagt gcaaaaaggc agctgagata cttgcccttg ggctgcatca 44100 taggctgcct tactatcttt ctctagccaa gtctctgctc gtgctagggt aatcggtccg 44160 tcttccccag ggagttgcaa gtggccataa ccaccagtta tcttcccgag ggagtctttg 44220 taccacttta gtaccaaccc ctctcttcgc ttgattagat caaggtactt aagaggctgg 44280 gaaagaaatg actttagcca actctggctc ttcgtcgaga attcgtcgaa cttcactgat tagtcctct gcggacatat cttccacatt cttagtagta agctccagtt tctgcttagc 44400 tccgaagcct ccacgatcca ggatatcctg ggccgccttg aggcgaatcc cacctttctc 44460. ttctgggttg ctagcgatct ctacaaccac acgaagcgcc atggggacgt gactcccgat 44520. gcgctcagag ataaaggcgt tgatgtattc ggcatgcttt cgatggtatg cagctacgtt 44580 gcgttgcgca tgattaggag agaacccagc ggctatatat gcttgggttt tgttcatacc 44640. atctgccaga gcctcacaat agaggtctag cttttcttta gcagaaagag gagcagcccc aatcgagaca accttttcgt ctgacataca ctgctccgat ctctctaaat ggtcaccccg gtaggactcg aacctacgac ctcctgtgtc caagacaggc actctaacca actgagctac gaggagtta tggtggtcga aggaggat tgaacctcta gcctaaggcg tccgggttac aaccggatgg tagtagccat ctacctctac aacgaccttt gttggcgacc catgtcggat tcgaaccgac ggcttctccc tagacagggg agcactctaa ccgctgagtt aatgggccat aatggctggg acggtagggc tcgaacctac gacctgagag ttaacagctc cctgctctac 45060 caactgagct acatcccaat gaattctaaa ggttaatttc tcaaccttat atactatta 45120 tatcacactt tttctatttt gtcaagccct ttttcatct ttttatttt tagtcgcaag 45180 acccggattt gttagggttt ttgctggaat ggggaagggg ttcttaagac tatcttaaga 45240 taaccttaag gtaactaacc ttcttagtaa gtaagtcaaa aggaagaagg aatcttaaga 45300 gcctataggt ctattatact acattttgga tac 45333 <210> 4 <211> 44884 <212> DNA <213> Bacteriophage P1797 <400> 4 ctaaccttct tagtaagtaa gtcaaaagga agaaggaatc ttaagagcct ataggtctat 60 tatactacat tttcgatacc ttgtcaagta cttttgata tttctttgat aatcacatga 120 tttacccgac gaacggtatg atagggttct atagatatac cctaagacta cccttcgtag 180 gttgctggta aggggtaagt ggcatagggc tcccttgatc caggttctat aggtatacct 240 tagggctacc tctgttctct atgccctggt ctattgcccc tttatccagt aatataccaa 300 cagttatcga agggtgcctt tgatccaggg cctataaccg ggggataccc caaaagtcta 360 ttttatcctc cggtgtatct ggggaatatc cccccaggag tcccccagat aaagtgggg 420 tggcctatcc ccaggggtat agcccctagc ccctccctag gataccatga gactaacccc 480 aagatcaacc cctagggata ccgttcatcg ggtggaccca agggtattca taagaaaaat 540 cttagggtat tcagggggtg gatcgggggg aatatccatt gataacccct tgatccccta 600 ttgacttccg ttgataccct atgttaatca aagactgtct atatccgggg gtttgctgggg 660 ggactgatag tccataggct gtatgaaaaa ccagtagaca accccgtaaa gaatatggcg 720 taatggcgcc gccttgaggg aaaccgatag gcaacgggg aaaccccagg ggcttgacaa 780 accccgcgga accgggtcta atggccccca cgttctacct aggccaccat cccccttgcc 840 gcagtgctat ccggggctg ccaaccaggg aagagcgccc aagtcgccca agtgtaaagc 900 cggcaggtat cggggttga caggggatcg gtgaagcggt atagttcgcc ccacgtcaac 960 ggcataacgt gcatgactcc ctcgggatta gcgtagcctt gacaagcaag actgatggcc actcagcaaa agagcctatg ccagagaact ggacgaacta acccccgtca gagggttgac aaggcaagcc caagcctcta acatgggcac ccatcaggtg acggccacct ggggaagtg taccttcgac ggtccttgga ctgaacaagg gagaaacccg aaagctgagg gaatacgca 1260. cctccgaaa gagcgtaggt cctggccttg taccatagaa ggtccgactg gtagcctgtc ccagcgcaat caattgacag accccgtggt tcaagcgcga cggggagtat gatgggttag tgtcgaaggc ttagcgcaga gggcgaagct tggtagatac ggcgaaggta ggggcgagtg gatacgaaga cccccgagga taaccgagga cagaccataa cgacgacact aacgcggaaa ggggccggct acgccaatgc caaggtttgc cgataaccc ctttgtcgta tcgggatgtg tgtcccggct gatgattcct aaaggatgaa acgaccatga ctcaggctct tgacaaaaaag ctgcgtcgca aggccaccg caaggccag gctttgggtt acaaccttgg gaatctgggg aaggcccaac agcgtagtga gcagaagttt gggattattg caagttgtaa caagatcctc gacgacaaga ccacttcgtt gcaagaaaag gcaggggcgc gtaaacgcaa ggctcttatg 1740 agtaccgact ggcgtaaccg tgaggttact aaccttgga actggtataa gccgagcaag 1800 tgcggtaact ctgccgtcat cactgtcgaa gtaaacaact gaggtaatta caatgagcga 1860 ctacaagcgc atcaacggga tcatcaagac cattgccaac cggggtgctg ccctggacaa 1920 gctgggttcaa accactggca tggatatcct caagcacatc gacgagcatg gcgaggtgtc 1980 cttggcctgc aagctgttca acgcgatgcc tcaaggctcc cgccggctgg ccctggccca 2040 ctggttcatc gacaacggca agatcgaggc caataccgac aagaaaagg ccaaggaatt 2100 cccgttcgtc ttcgccaagg acaaggccac tcgtctggag cgtgccgcag agaaaccctg 2160 gttcaagtac aagaaagagc gtgacgtggc cgacgagttc tccctcgatc aagccatcgc 2220 cgccttcaag gccaagatcc agcgtgccat cgacaagggc cagctccagg caggggacga 2280 gcgtatcgcc gtgatccagc gactggaagt caaggacgaa gcgaaggcag cgtaacgccg 2340 ggtgcgccag gggtgtgtac tatgacgcgc ccctggtcta tccctagagt gcatggtagg 2400 tccgtgcatt gtagcgatag accatcagga ggtttccgtg ggttactgta tctttgggca 2460 ggttcattcc atccaaggcc aggattatgt ttctggtttc tgcgatgcaa gggtaggttt 2520 cgacgctggt attgtgtacc gttggacatt caaggacggt aaatttgcct gcggtgtcta 2580 ctccctggat ggtatccgtc tgaacatctg cgggtggatc aaatgaagtc accctacgaa 2640 gcggcccatg aacgtgccca aatgattaac cgtctcaaga aactcactag gatgatccgg 2700 gtgcatcccg atccccggtg gattgttgag cgtcaggaac tcataaggaa actaagcaag 2760 tgacaatcgc tatcattgta tccagcattg gtatcgccta cttcttcttt cgtgattgga 2820 aagaggaaat gggtatctaa ccccaactga tgaggccaag gtgattcctg gccgaaaccc 2880 ccaccggacc tatggtcgca ggctggggcg tcttgggaaa tcaactaagg aaaccatccc 2940 gtgaagcgca acgactaccg aaaggtgaat cggaacatgc aagccatcga ggccatcgac 3000 cgcaagattg ccaaggctgt ccgtgagttg actaactccg gaggaaacca cgttggtaaa 3060 accctggagc tgaatcggct gcgggctaag cgtgcatcgc tggccaaggt aagggcacgg 3120 tgagtacatg gaagtctatt gtatgtgccg ccatacgctc acgttccaat gggttgctgc 3180 tggtaacgtg ggtggttctc ttcgtcctgt cctcgatctt ggacagcatc cctttgcat 3240 cgtgaggtag tcccatggat atcaaggtgt ggccccgcaa cggcgtaacc ctcagttctc 3300 tggttaagtc ccaaaccttt ctcatcaatg gggatgtgta catggtctgc gaactccgaa 3360 gcatcaagat gaagagtgaa tctgacgagg ttcccgttct caatctcaag actggcaacg 3420 tcatttacat gcctccgttg agcctggtat acccagtaac tgccgagctg aattgctacg 3480 aggtgtaaca tgaaactcca atacaacatg attaccagta agatcaaggt tgtgatgtgg 3540 aatgaccttg agccgggttg cctgtacatc ttcgcagagg atgacgggaa gaagaacccc 3600 aaagtcttcc agtacctgga gcttaatgat gaattcttca tctgcgaaat cttcggcgga 3660 cctgaggcg atgtattctt cagcagcgat gttgactgcg ggttcttccc ggtgactgtc 3720 aagtacgcag agatcgaagt ccatcggttc ggcctaccgg actgagggtg tgtactatga 3780 cgcccgccca atacatctac ctctggttgg tatccaaggt tgtcatccgt cgataccagc 3840 ctaaccccaa actgtacccc aactggtccg ttactcatat ccgtgtgtcg atcttcggca 3900 aacgtgcagg tatcgtctat gaaatccact gaaccccaag tctattggct ggctagcgcc 3960 gatggtgaat tccacctcaa ggtcatcaac ttcggccagt tcatcaccga aaccctttac 4020 gaactcggca ttccggtgga ccacaaggtt catcgggtcc actgaggtgc aaccatgtca 4080 aacaccacct tcactgtagc agcaacccgc ccccggaacg accttcacat cagtaagcgg 4140 gcggatgggg tttatgtgaa ccctaaaaac tctggcgata ttgtcttcct caaggaaggt 4200 aataaggttg tcgtcctcag ccagagcggg ttcagcatcc tcgaagccca gaccatgccc 4260 aacatcgggg aactctgccc ggctaaggag gtccatgtat ccgccagggt atggggccg 4320 tatgaagaat aaacccatga tcggccagat aatggcccag gagcgccgca tgaagcgtcg 4380 tgtagaaaag cggggttca acatgagcct ccaggaaagc ccccaggagc cccgtggtga 4440 gcttggtttc accctggctg ccgtaggtat ggagtccagc cgatcggctt acctgcgtca 4500 cgccagggag gctatgatcc aatccgggga gccttgcccc cattgcatgc cagtcttcgg 4560 tcccaaagag ggtcgttgct gcaactgcgc gagggactgg tgatggatct cggtaatctt 4620 tggtgtctct tgggtgtcca tcggtacaag atacttgatg gtggacccta cgagattcgt 4680 cacaagggtc ggctagtgga actctgccac tattacgacc tgaggtgtga tcgctgcggt 4740 gacgtacatc ggaaggtggt ccgcagcaaa tgatgacata cctcctgata atcccagcga 4800 tcctgatcta tatggcttta tctttgctcg tggctggcat cgccgggttg gcggcaaatt 4860 gcgatgagca tggaaggatg agccagaagg atcaggacat ttcaatcatc ctcggtatcc 4920 tgtggccagt gtcactacct tggatgtgct tctcggttgt tatctggaaa cctttggcta 4980 ccaccatccg tgcggccaaa cgactaatca aaggagatta ctaatgcacc gcagagactt 5040 tccctcctgc tgtaccgcaa aaatctacat cggcatggga ccctcgggta cgctgacca 5100 ttacgccggc ctcgcatcca acgggttcag cccccgtggt ttcgccaagg aactgatcgg 5160 cgccatccgt cgtgaatcca acgagggcca cggtacgatg gtcttcacgg tgaacagcga 5220 gcaggtggta gcagatacca tcctccgccg catgggcagc cactacaacc cctgggcatc 5280 caggacaac cactcgacca aggtccgggt ccacgtcatc aacgtgaagt ctgcggcaga 5340 tatcctcatc aaccatgggg ttctccgtcg tcacctcggt ggcttgcagg actaccccgg 5400 taccgtcgag cactcggagt acctcgacaa gctctgtaaa ggtctgtaac atctaggcct 5460 tgacattctg ctggaagtgt ggtataataa ccttaaggtg ccgggggttg ctttatatcc 5520 ctaaggtacc taaggttcta ccttctatct tcttcatctt aagaaagagg taagaacaat 5580 ggtcctcaag ctctacactc gggtaatgct cctggctatc cccgcatggg taagcgtaag 5640 gttttctacg agcgtctctg ctccaacggt gaattgaccc tgaacggcaa cctcaaggcc 5700 accaaggtgt cggcaccaac caaggcaag caacagcgcc gtggcacctt ctaagtaact 5760 tagaggtcgc tagtaatacc cctagtattc ctgtcctggg ggtattgctg gctaactcaa 5820 ccaaggagaa aacaaatggc ccgtatcaag tatgccttcg gtatgaaacc caagaagggc 5880 gagggtaaag ccctcaaggt aatgacctct tcctcctgct tcggtacaat ggaaggtccg 5940 gtaacccacg gctataagct cgacggttgg accttcatct gctcccgccg aagcaagaag 6000 ttcatcgatg tgctcaacaa gtgtacccaa ggtgaactca agaccatcac catcggcggc 6060 aaggccttca aaatcccgaa ggtccacttc tggtcttacg aaagcaaggc caaggattcc 6120 cccttcgaga agtattctaa cgggacggaa atgatttccc ccacccatca cggaaaaagaa 6180 ggggtctgcg gtatctactt caaccccaag gtacacacc tggattcctg gtaccccatc 6240 atgaaattcc tcttcaagat gatctccagc ggactcgact accaaggtcg tgaagaggag 6300 gttcacctga agcttgctga gaagtatggc ttctggagagt cctacctcgc aatgtccttc 6360 cacggactga tagccaatgg ctacaccggg taccactct ccaactacat gttcagtagt 6420 gattgggatg atctcaagaa gggagatatc cacatccaat ccgctgacga gtctatccga 6480 ttcggtcgtt ggatgcccaa ccgggatgcc ccaggtggac gtgagtgggt aaagaataca 6540 ccctggcggt ctgaattcct gaagaattcag ttggacaagg tggaggtagt taccatagca 6600 cctcagccaa ccatcttcgg aaagaaagat ccctacatga ccgtagatag cgagatggga 6660 ggtttcatcc gcctttatcc tcatacctgt gaaaatacg gagtggtcat gctgggggatc 6720 atgggtgagg ttggctgggg gagcggcata aggattatct tactggccct cgaagacttc 6780 atcgagaaaa acttctgaca accaaggaga aatcaaatgg gaatgtatgc agcctaac 6840 gtgtactatg atgtcgaggg tgctgagatt ggtcactgct gcgtaaaata cgtggctgaa 6900 tataccaact gcttcggtgc attctgcgac gaaacgggac ctttccggga tgtagtgtgg 6960 gagaccgggg ttggacacct cctggtgtct acccacgaga acactgctgg taagttggtg 7020 gagttcttga acagtgatct ggtcaacagg atcaccgacg gtggaatcct ctcagcttcc 7080 caggactggc caaccaagtg gtggacagga tctgacgggg ctacccaaaa cctctccaat 7140 cctgaccact tcagcccccc tggccgccga caggctgtgt acgttcgggt ggacctcaag 7200 aagaacgcat cggcaatcat ctgtgccctc cgaatgggag atcgcttgtg gggtgtaggt 7260 gattccatgc gtcgcatcac ccaggaaaat cgtgataaga tcctggtctg caatgcagag 7320 atcctcaccc tcgcggcttg tgcccaggta ggtagcactg ctcattgcga cagctacccg 7380 gccatgttcc cggtgactgc tggtgaatac cgggagggat gcgagagcca cggctgggag 7440 gtggatgaca gctacataag cgaggtcatg gatggtatcg taggtggata caagaatatc 7500 acctacttcg atattaagag catccatgag cggactcgcg aagagttcaa ggacaagctc 7560 aagcatcacg acgctgagtt gtggcagggg tataccaagg atgatgacct gatcgaatgc 7620 gacggtctcg aaggtgtacc taatgaccga atcctttcca tcatggcccc aatcaccatt 7680 gacgtcggtg acccaggtcg ggaaaggtcc gaggtcgtac ccaccagcca atacagcatc 7740 cccgaaatcc tcgaaaaact ggagaacatg caatgaacaa cgcaatcccc ctgatcggtg 7800 cagatcccga agttttcgtc ggctacgacc gtaaccccca gagcgtcatc ggcttcatcg 7860 gcggcaccaa ggaagagccc ttggctgtag ccggtggtgc tgtccaggaa gacaacgttc 7920 ttctggagta caacatcgac ccggccagta ccaaggaaga gttcgtggag cgtatcgtct 7980 ccgttcgact cctgggtgcc cagatgctcc accccttcgg catgaacatc atcgagaacc 8040 tgtcctctca cctgtacgac gaggaactcc tccgcagctt cggtccccag gcttacgtct 8100 tcggttgcga gccggactac aactgctgga ctcgtcgtca gaacgtgatg ccgaaggatg 8160 cccctccgac cctgcgtact gccggcggcc acgtccatat cggcttcagc cacatcgagc 8220 gagtcaccaa ggctaccacc agaaagtca tgcagatgtg tgactacctc ctgggcctgg 8280 cctctgtcat cctcgatggt gacacccagc gtaagaagct gtacggcaag gctggcgcaa 8340 tgcgctataa gccctacggc ggcgagtacc gtagcctatc gaacttctgg atcttctctg 8400 tcgatctgac cgagtgggtc tatgaaatgg cagtgcaagc ctacacctcc aagcacctcc 8460 tgggggagatcgatc gtatccggtg atgaagtcca gcggatcatc aacgagaacg 8520 acggcgctgc ggcagttgcg gccctccaag ccctggggt gaagttgaa tgacctgaat 8580 aatcgccatc ggttggccgg ggacttcaac atgtactact cctccaccta tgccttcttc 8640 cgggttgacg gtgagcctcg ggtagtgtac gtggacgata ccgagtccat tggtgacgac 8700 cgtcaattcg acgggtttcg tctcctgggt aatgtgtatc gccccgacgg cagtaactac 8760 tacggtgggg ttgtctacag cgaggtagaa agcgtgcggc cctccagtgg gtactatgac 8820 gtctttggcc gtggggttcg tgatacttat gtatccttcc tcgtgaacaa tcggactcag 8880 cgtaagggta tggaccccag gaacatcctg ctgaaccatg cccaacaggc catcactgga 8940 gaaatgatga tccgaatctt cacccaggcc gaggaaatga tctctgcccc atcccaccgg 9000 gacttcttca tcaaggatgg ggtagttcac tggaaggggg tgaaggttgg tcagatggta 9060 gatggccgac tgtccgcaga tgaacaattc aagaaccagg aggacttgct atgtcagtta 9120 ttggcacaca gatagggttc cgtaagaacc agatcattgc cccggaacat cacgaggaac 9180 tgcctgcggt tgcttccttc gggttcgaag tcgaactgga aggcctcaac aactggccgg 9240 aagtggacgg gtgggatctg aagggtgacg gctctctgcg ggatggtatg gagtatgtct 9300 tctccggtcc cgcctctggc cagaaggcaa tcactcgggt tgaatccttt gtgagtgcga 9360 tggaggaaac tcctccggcc cccaccttcc gttgctccac ccacctgcac atggatatgc 9420 gtgacgtaga gtggcctgtt tatgaacgaa cggtcctgac ctacatggca ttcgaggatg 9480 ttttcttcga tcactgccaa ccgtatcgtc gggatagtaa cttctgcatc ccgttcttca 9540 gcaacgactg gctggcccag accttcggtc gccgtatcct ggccccggaa ggtgaccgag 9600 agaaagtctt gggtcttacc tcctggccaa agtattcggc cttgaacctc caggtaaccc 9660 acaacttcgg gtccatcgag ttccgtggtg cccatgctct cactactcgg caggaaatgg 9720 taggcctgat gcagcgtatg ttgtgtctca aggccttcgc catggctcac gcagaaaccc 9780 cgctggaaga gttccttaag gtactctccg aggtgaatct ccgtgatgta ttcttcctgg 9840 gggtatctcc ggactatgaa atgtctccgg gtggtcgtga aatggggatc gccagtgcta 9900 ctctcgcggt agcaaccatg ggctttgttc gctccggggt agatcccctg gaagatgaac 9960 agaaccgtca gcgtcgtctc cgggagcagg aacgtgagcg tcagagggct ttggatcgta 10020 ggctgctctt tgctcgcgct attacctcac gactactaga tggtgcagca gagcggtaca 10080 acttggcaat ggtgccaggt acccaggttc gactggatac ggcgattact gcggtaactt 10140 ctctgcgtcg tattggtcac caagtgcgtg tacgagacct tctggaggac caagaggctc 10200 ttcaagatgc cttcgtactg ctcatggata acccgcagca ccttcagcgc cataccggcg 10260 taacaatcga accagatatg tactaaggag aaatacaatg tgtggattgg taggcttctg 10320 ttccacaact aacgcgagtg ataacgaaat cgctcttctc aaatccctcc tggccgtgga 10380 tattatccgt ggtgctcacg ccaccggtt ggccaagatc gacccggtta agaacgaggt 10440 aggaattcac aagcgggcag tagatgccta cgacttcctg gctgatcctg aaaccaagga 10500 gttcctggac aagggtcggg ctcgcatcta catgggtcac aaccgttacg ccacgatggg 10560 cgacaagacg gaccatggga atgcccaccc cttccaggta gaccacatca ccatggtaca 10620 taacggcacc gtagatacct ggggcctgca cctgctggat ggcaatgata agtacaacgt 10680 ggattcgaac atgctgtgcg ctaccattgc caaccacgga gccaagaaga ccttcgaaga 10740 gaagttctcc ggtgctgctg cggtaatctg gtgggactcc aaggaacgta ccctgaactt 10800 catccgcaac gatgagcgtc cgttgttcat ggcggtgacc accactggta ccatcgtgtg 10860 ggcatccgag cctggtatgc tcaaggtttt cctggagcgt cccaacgcta agatccgcct 10920 tcgttctccc atcgctgaac tgaaggctga agtcctggta actatcccgt tcacggaggc 10980 cggagtgcga aagggtgcag aaccccagac cactccggtc acgtttctgg acctcccaat 11040 tcccgaaagc gaaggcaaa cagcggcatg gtggagtcgc tacgtcggtg tctcggacta 11100 tgatgactac agccgaagcc aaggcagcca agcgggaacg aaaggcagcc aagcgggtc 11160 gtcgtatgga acgtctggcg atgcgtacgc aaagaacacc ctccggatca acaacaacct 11220 cgacgcagca ggtagcacct tcaagcaccg gcaactcgtc accttcgatg ttgtcaagat 11280 cgaggcctac gcaaacggca gcgagtacgg aactgtcact ggaatcgagc gtgaagaaaa 11340 ccttctcatc gaagctcatg gcatcaacgt cgccaaggtc cacggataca ccgtcctccg 11400 agggagtatc tccaatgcct acttcatcgg ccaagaccgt gatctcaagg ttactgtcga 11460 ggatctggcg gtaagctgcc tggacccaaa gcatcggccg actcctgggg agactacccc 11520 agtgttgagg attgggaacga tctcatcgga gacgaaatcc cattctaaac ccagggttca 11580 agtcggcggc acctcggga atacccctcc ggccaacatc agctacccct tgaaggttca 11640 gggacacag ttcaacaacg ttcatgtctt tcgggacttc gtatcccagg ggtgtgcatc 11700 ttgcggtaag atccctaccg cgtatgacca gcgtaatcgt catctgacgg tgtacgaggg 11760 tgccaagttc actggtagcc tggatgagtg cgagttcatc tgtggtgagt gtgtaatcga 11820 aaataaatag gaggtcaaaa tgacccaagt aacgatgaag cgtcaagtag tgatccagat 11880 ggagaccgac gcaacccgta agtatccctt ctcccgtgac accctggaca agatccagtc 11940 gattcgtcga gtcaaggagc aggaactcaa tgatgccaac ccggacgagg aattcctggt 12000 accggccccg gtagtcattg cggaagctat cgaccgactc ttcgaagact acttcgagta 12060 aggtagtgcg ttagtaatag tccctggccg acccatgccg gttcctaaga tgcgtacatg 12120 ggatctaact taggattcca ggggctattg ctggcttcac taccctcaac agaaacagga 12180 gatttgccat gttctatatc tataaaggtg cccgcccctc tgctggtgct gtcgctcttc 12240 gtaacgccat gggtgctcga atccttcgct ccgaggggtc tacctatcgg ggtcgttcgg 12300 gtactgcggt aatcaactgg ggaaccgttg gtgcagaggc acgacgccta cagggtatcg 12360 ccccggtctt cctcaacgac ccggctatgg ttgctcgctg caccaacaag ctggatttct 12420 tccgccactt cgaggccaac gccccccatc tgatcccccg ctggacggat tcctgggcta 12480 atgtccaccc gatcctgaat tcctgcggtc gaatgtacgc tcgtacggac ctcaatggtc 12540 atagcggcag gggtatccac ctggtgtgca gcatcaacga cgcagaagtc caggccatcg 12600 atgcccttcg tcgccagggg aactacccgg tacacatctg gggtcatacc cacatcccgg 12660 aggtcgtcga gaacgcccaa ttgttcaccc agggcatcgt cggtaagcgt accgagttcc 12720 gagtccacat gatccgtggg gaggtagccc tgctccaggt caagctccga cgtgttgcca 12780 atgaaatggt gaccaacgaa ggacaaagta tcgttcgtaa cgtagctggc ggctgggtct 12840 atggcgtcaa cgatgcaatg ggacgggatg gcgctgagca ggctatgtcg gcagcagcag 12900 aagctatcca agttgcaggc ctggacttcg gcgctgtgga tattatctac cagcacgcta 12960 ctagccgggc gtttgtcctg gaaatcaaca ccgcgccggg cctggatgca gaaggcagcg 13020 ccctggaggc ctacgtcaag ggcttcaata aaatcttcga ggagactatc taatggctgt 13080 tcgtgttttc gtttatggta ctctcctgtc tggtttgtac aaccactacc ttctggaagg 13140 ggccgagttt gtcggcaatg ctgtatcctg cgagcggggt ctgatgtact ccgctggcgg 13200 cttccctatc ctctccttcg cctcccgtgc tgatctcatc gtaggtgaaa tctggcaact 13260 ccccgaaggc gagaaggggg aggaaatgct ggagaacctg gatgccctgg agggttatcc 13320 gggttggtat gatcgtaccc tcaaggattt ccgaatcaat ggggaacgaa tcaaggccct 13380 ggtgtaccat caggatagcc acatggcgat ggatatcgtc aaggatggcg actggaaggc 13440 acacctggca aaacgacaag gagcagtatg atggatgaaa tgaccgtaga caaagcagta 13500 gaagtctacc gcgatactcc gaacaccttc ggacaccaag agctacatgc ccagaagatg 13560 ctcctcaagg agatcctggg ccttgtcgcc tcccaacgac acctccaaga ctccatcgag 13620 gtctccaaga ttccggaggc ctcggatagc cccgagacca gctacggcgg gtactgtgac 13680 gagtctgttg gtattcgctt catgtgggag cgactgaaga agatcgagga ccgcctccgt 13740 gaactggaga aggtctacgg tactttcgta acaactcctt acaagaccct gccgggcaac 13800 gtcaacgctg tacctagctt ggtgctcaag agccagatgg aggaataagt gaagcagatt 13860 atcggtgata cggcctgtcc gggttgccga gctaaaggtg gggataaaac aggtaatcac 13920 ctcatcttgt tcgtagacaa agagaaaggt acccgcttcg gtagttgtaa ccgttgcggc 13980 cactatgaag tcctcgaaga agggttcaag gttcctgaac gaagggagaa gtccgaagag 14040 gatatcatcc atgaagtcaa cgaagtcctt gagtatccaa ttaaagccct cgatactcgg 14100 aagatcagca aatcaatcgc tgaacgatac ggggtacgtg ttggtctatc acaagaaaac 14160 ggtgaggacg ttatcgagca ttactatcca cgcacccgcg atggggagta ccgagcgttt 14220 aacgtccgaa tcctagaccc taaggctttc tactatcgtg gtagccccaa gggtggtgtt 14280 gaccccttcg gttataacac ccttcggcat aaggatatgg gccacctgcg gttagtcatc 14340 tgcgaggatg aactgtcggc aatgtcagtg gctcagatca tggagtcgaa gctgcccgag 14400 aagtggaagc acctacgtca agcagccatt agctggtcct caggtgttgg ttctgctgga 14460 cgggatatcg cattcctaaa ggaatctggt gtactcgaac ggttcaacga ggtcatctat 14520 tgccacgatg ctgatgacga ggggcgtaag tcagtagaaa aggtacgtgc cctgtacccc 14580 gagtgtaagt tcgtagagct tcccctgaag gatgctaacg acatgcttat gcgtaatcgg 14640 ggggatgagg tctaccagat gatccgattc ggcagcaagg ttaagtcccc ggactgttcc 14700 gtaactgtcg atgaggtata cgctgaggcg ctagaacccc ctaagtgggg taagagctat 14760 ccctgggaag gtctaaccaa ccttacctat ggtcagcgtg atggtgagat catcggggta 14820 ggtggaggta ctggtatcgg taagaccctg ttggcccacg agattgctgc ctggaattgc 14880 attgagcacg gggagaacgt agggacattc ctgttggaag agcaggtagc catgacactg 14940 aagaatatcg cggggaaaggt agctaacgta cccttccacc gaccggatat cgagtgggat 15000 gagcaagcct ttaaagacgc tgcgggtaaaa ctccgtggca agctcttcat gtgaagaac 15060 aagggtcaga acgattggga tcatatcaag gaatgtattc gcttctgggc agtagccatg 15120 gatgtgaaga ctatcctgct ggataacatg accgccatga ccaaccacct tagtccttcc 15180 gaaatgaaca cggagatcgc ccgtatctgt acagagcttg caggtatggc cgatgagctg 15240 ggtcttcgga tcttcatctt ctcccacctt aacccgccca agggtaatcg tacccacgag 15300 gaaggcgctg aagtaaaagga aagccagttc accggctccc gagctatgca gcgttggtgt 15360 cagcttatga tcggcttcga gcggaacaag caggctgacg gggaagagaa gcacgagagc 15420 agaatccgtg taatcaagga caggaactac ggtaatactg gactagtgtt taccaagtat 15480 aacccagaga cgggtcgctt ggttgaacgt gagggcagtt acgacgaggt acctgctgac 15540 gatgacaccc caatttgatt acgttatcta tgacctagag ggggacggcc tcttcaatac 15600 ggtcacaagg ctttggtgcg ctgttgttgt agacattccg actggggtag tccggggatt 15660 ccggcccgag gaaatggatg tgttctagat gatcatcgcc catgcaaagt tcgtggtcgg 15720 gcataacatc ctagactacg acaaccgggt ccttgagaaa cttcatggga ttatcatacc 15780 ccccgaccga agctatgata ccttggttgc atcgaggttg acttggccag ataggcccca 15840 gggtcattcc ctgggagcct ggggtaagtt cctgaagtgt cacaagggtg acttcaacga 15900 cttctccaag ttctcagagg aaatgtttga gtattgcctt caggatggag tggtcagtca 15960 cgcactgttc aactacctcc tccgggtact cggcatgact tggcaagagc ttgttgaatg 16020 gaggactgta gattggctaa aaagcgagtg aggaactaca agcgtgagag agaactggct 16080 attcgacgcg gcgaaacggg cgtgggctct aagtcaggag atgctcagcg gcaccgagcc 16140 cgccgaaagg tggaaaagcg tcttggcagg aagctcggaa ccgacgaggt tgtcgatcat 16200 atcaaacgtg ttaaagatgg tggcggtaac ggggattcta atcttcgcgt ccgtggccgt 16260 tcttctaacg ctgctgatgg tggtcgggtg ggcgatcgta aggccaaagg cattcgcaag 16320 aaaaagtaaa tgaagagggg ccttcgggcc cccgaggact cattatgttc aatcgaaagc 16380 taagcatcag taaaatcctc agttcctttg acaacgagat caatctactg aagaccttta 16440 tcaaagagtc ttcggatgaa tctgaacgga tctacaacga gatcagcttc ctgaaggcgg 16500 agcgtaccca ggtcatgcag gacaacctga aggcccagaa ggtactggct aacctggaag 16560 aactgctggg aggtaagagt gaaggatat cgagttaatg tggggttcca ggacaccaag 16620 gtgttcaacg cagacttcta ccgcatcgag ttggatatca tccggttctt cgcgggagat 16680 tctgatgcca accccatgac cgtccgagcc aatgagatcg gtgctgtccg tggatgggtt 16740 16800 ggagattgcc ctggagaagg agttctctgg tagctgggggt ggccccgaga tcgatgctga 16860 tgacttcccc ttgggtagtg cctgtggcct agatcccgag gtatgcgagt catgcagctg 16920 agccagtgcg taccctggct gtgggctact gatcgatgcg ggtatggggt ccttaccttc 16980 aaggaaac tcaggaaagc ccaccgggtt gcctactgta tggccaacag tctacaaatt 17040 gaggacatcg acggggttat catcagacat aaatgtgata acccatggtg tgtaaatgta 17100 gatcacctcg aacctggaac tcatcaggat aacgaggatg ataagaccaa aagaggtagg 17160 cgacctatgg gagagaaggt tggctcagca aaactgaata gggctcaagt agagtccatc 17220 cggaaggagt atgtaaaaag ctcaaagact ttcggttcgg ttgccctggg taagaaatac 17280 ggggtacatt cctcaacgat cagatacatc atagcaggag atatctggtg agtatcctag 17340 cgcaagtcct tgtcatcttc tggagtgcat tcttccaggt attcctcctg ggattgaact 17400 ctaagctgct ccgggatgac aagatcaagg ctgggttcgt aggtcttgg tgtatcacgc 17460 tggctcagtt tgcttacatc aaggcggtag cctcctccca cttggatatc ggatggttta 17520 tcttcgtgtc cgggtgggga ggtgcccttg ggattacctc tgctcaatac ttctacaagt 17580 ggtacgacag ggtattccac aagaaggctt gacaaatcca gaaaagtgtg gtataataac 17640 cttaaggtgt ccggggttgc tttaccccta taggagatac aaatgagtga ccatgtaagc 17700 tattccaaac atgtccgtgg caagtacctg tgtaatatg cctctgccct cataagagc 17760 atggagatac aaaggactaa catccggaag ttcctcagca gtccccagat tactctccgg 17820 gagaagcgtc gggtattcct gagcctcccc gctggattcc tgggggtgag ctacttctca 17880 ggctcccacc tgaatctgag ttcctactcg cctaaacgca atagccgggt acggggagaag 17940 gatcttagcc tgtacgacga cttctacatc gacggata cccagctaga tccgcgagac 18000 ctcttgttta cctcccaaga agagaagaaa tgggagtttc aatacctgaa ggagaagcgg 18060 ggtgatgggt tcgagctatc cgatgaagaa ctgagcgacg ttaaggatat ccagcgcaag 18120 atcgacctgt cctggtacct ggtagacctg gcctgtgaac gtgggtgttc ctacttcatt 18180 ttcgactggt gattacatga gcaagatcaa gagtatcctc atggagcgggg tagatgactt 18240 cctgctcaag caagttgctg tggccttcct ggagcagcaa tggaagctgg accgcagtgg 18300 taccgtggac tacctctcct acctggaggg tgtatcccac gaagctgtgg agacagttgt 18360 agagaatctg gcggagcgtc ttaaggggga ttaagtggat tggagaaagt cactgttcgt 18420 tgagcacaag gtagctgata tcatcagccg ccagagtaaa cgtggagtct acttccagac 18480 tcagcgggcc aagtggctga tccatgtgct tagggaacga atcctcaaga ttgaccttga 18540 ggctgtcccc cagatgccca tgatgatcgt aagggctggg gccttcagca agccattcct 18600 aaagagtggt aagccgaacc aaaggctcca gtccctgtgg caacgtcttg ggcacttcga 18660 18720 gttcaaggac tggatgctgg atcaggggtg gatacctgac caatggacaa tcaaggatat 18780 tactgtcggc actgatggca agaagctacg tggatctgac cttaatgaat ccttgaataa 18840 gtacattgag gatctccgac agagcaagtc tggacgactc cgaatgaagc tccaggggat 18900 catccctggg aaaactacca ttggggaagt caagagaaag ctcgaaaagc aacgtaaggt 18960 cctaacgact ccgaagatga ctgaagagtc gatggatacc gtccagggag acctgggaaa 19020 gctggtgatg cagcgaatgg tttgggccca ccgtcggtcc ctcttgcagg ggctggtaga 19080 tcaggtgagg cctgatggac gcctagaggg gagtgctaac ccctgtgcaa cacctacggg 19140 ccgtatgagg caccgtgtag tagtcaatat ccccgctgct cgttctcctt tcggacctga 19200 aatccgtggg ttgttccagg ggacacctga ggctggtgaa tggaaatgga ctgtcctccg 19260 ccgtgatctt ggggagaacg aaagggttag gcccttcact aacatcgtgg aggaactcaa 19320 gaagggtaag tggaagactg taggaaagta ccgggtatac gtcccagcga accaattagt 19380 attcgtgggc tacgatggtg ctggtctaga gcttcggatg cttgcatcct acatcaacaa 19440 cccagagtac accaaagagg tggtcgaggg tgatgtacac acggccaacc agatagccgc 19500 agggcttccc acacgggatg atgctaagac gttcatctac gccttcatct acggtgctgg 19560 ggatgccaag atcgggacta tcattggtgg cacaagggcg gacggggcta agctccgggc 19620 ccagttcctt gaagctaacc cagaccttgc tgcactgatt gagagggtta agcaggaagc 19680 cgagaggggt tatctcgaag ggctagacgg acgaaagcta accatgcgac gttctgagtc 19740 tggcgacgtg atgatccaca aggcattgaa caccctcctg caagcagcag gtgctattgt 19800 catgaaatgg gcaatggtac tcctggatga gcgagtccgc aggttaaacc tgagggcttg 19860 gaaagtcttg gatatccacg acgaaggcca gtgggaatgc cacccagagg atctcaaggc 19920 gctacgtgag cagatggaag tctgcgttcg ggatgctggg gaactcctcg gggttaactg 19980 tccttgct agtgattcta ttgcagggag atcatggaaa gacactcatt aaagcataaa 20040 gtgggtgcta ttagcgaagc gagagcgaag cttatgtacc taaagagggg ttgggaggtg 20100 tactccccgg atatgcctca aagcagatgc gacttcattg tagatagtgg aaaaggtctt 20160 tttaaagttc aagtaaagac cgcctcttgg tgcaagactg gtaagtttaa tcactgccag 20220 ataaggcttg taaataggaa tggaaacccc tacgagaggg aagactttga tctacttgtt 20280 gtagtagatg ctgactgcat atacgaaata ccccatgatg acatcctcgg gaggacttca 20340 ctctatttca aaagtgataa cccaaacccg aggaagttaa aaagggatta caacccagag 20400 ggttgggtg taacacactg atacatctgg gggttgactt tcagccccct ctgtggtata 20460 ataccttctt ccctacgaga ggtttaagat atgtctaaga aagtttccca acgattcacc 20520 ttcccggtag cgaagctgat cttcccctac atcgtaactc cggacaccga gtacggtgaa 20580 gtctaccaag taaccatctg cattccgacc aaggaagagg cagacaagct ggtccaacag 20640 atggaatcca aagatgcccg tctgaagggt accatcaaat accaagagcg tgatggcgag 20700 tacctgttca aggtaaagca gaagaccac gtggattgga tgcaagacgg tgagcgcaag 20760 tctgctgtaa tgaagccggt ggttctgacc tcggacaaca agccgtatga tggcccccaac 20820 ccgtggggtg gctctactgg tgaagttggc atcctgatcg agacccaaaa gggcccacga 20880 ggcaagggta ctatgacggc cctgcgactg cgcggtgtac gactccacga gattgtatcc 20940 ggtggtgacg gtgaggacga tccgctgttc ggtggtgcct tcaccgagga agagccagag 21000 gacgtattcg acgaggtatt cgatgacgaa gacgctccta tctaaggggt tggaggatca 21060 tgagtcgggg gtatgccggt caggctgcccc ctactgctta attgaattcg agagagtgtg 21120 gggtgtaagg gtggtcagtt ctacagctgc atctaataat aaagtagagg tcgatcctaa 21180 tggaatcaag ccgggtgagc cgggcgctaa acttgatagc ggcaaggtgg atgttggaat 21240 catcttggaa gcgttcccga gggctctata tgcagtggca caagttgcta acttcggagc 21300 cagaagtat agtcgcgggg gttggaggtc tgtcgagaac ggagtccagc gatatgatgc 21360 tgccttcggt agacacctcc ttgagcgaca caagggtgaa gctttggacc cccaaagtaa 21420 tctaccccac cggtatcacg aagtatggaa cgccctagcg tccctggaac tcgtcattca 21480 gcaagaggag gaatccaatg gaacttctgt tggacccaag ggctaagact gttcctagca 21540 actactctgt gatgggcatt gatgtagacc tggggcttcc cccaggctac agcctaacgg 21600 aggaagctat ggacaaagcc aagcgtcaag agagcgagta ttacgactgg aaggggtatg 21660 aagcactggc caatccagtg gtagagcacc cagagtaccg agccaagggt gaagcctttg 21720 ccctccgtgt cttctgggaa gagaagctca aagaatccca ggtcgtagaa gaggtagcgt 21780 gatgatagct ggtatcgatg gtgacgttct taggtatgag ctaggccacg tggctatgtc 21840 gaaggaacac atcttcgata tccaggtgga gaagccatgg cctgaggaag aggtccataa 21900 gctcgtcgat gataaagtcg aacaaattat caaaagggta aatgcagatg agtgtgaaat 21960 ctaccttact ggccaaggaa attttaggct ggagcttgcg aaaatcaagc aatataaggg 22020 tactcgaatc ggtcttgaaa agcctcatca ctgggaaacc gtgtcagcca gacttaagga 22080 caagtgggga gcaatcactt tccacggtat cgaggctgat gactggctcg ggattcgagg 22140 cactgaagag ggagctaact ttacagcgtg ttctagagac aaggatatcc gccaagtccc 22200 aggatgctac cattacagtt ggccctgtgg agattcccag ccggagttgg gaccgtttca 22260 agttgatggt cttggaaggg tctccgcttc ttggagaatg tatggcgtta agaagccgca 22320 gaaatcatgg aagcttgagg gcaacggtac ggcattcctc tacgggcaac tccttgttgg 22380 tgactccgtg gataacatac caggcctccc agggacggga ccaaagacag cggcagattt 22440 gcttggggag ctttctagtg agagagatct cttc...

Claims

1. An antibacterial composition comprising at least (a) an inhibitor of Pseudomonas aeruginosa (… P. aeruginosa (a) a phage with lytic activity against strains of Pseudomonas aeruginosa, the genome of which consists of the nucleotide sequence of SEQ ID NO: 2; and (b) a phage with lytic activity against strains of Pseudomonas aeruginosa, the genome of which consists of the nucleotide sequence of any one of SEQ ID NO: 1 and 3 to 7.

2. The composition of claim 1, comprising at least (a) a bacteriophage having lytic activity against strains of Pseudomonas aeruginosa, the genome of said bacteriophage consisting of the nucleotide sequence of SEQ ID NO: 2; and (b) two bacteriophages having lytic activity against strains of Pseudomonas aeruginosa, the genome of said bacteriophage consisting of the nucleotide sequence of any one of SEQ ID NO: 1 and 3 to 7.

3. The composition of claim 1, comprising at least (a) a bacteriophage having lytic activity against strains of *Pseudomonas aeruginosa*, the genome of said bacteriophage consisting of the nucleotide sequence of SEQ ID NO: 2; and (b) three bacteriophages having lytic activity against strains of *Pseudomonas aeruginosa*, the genome of said bacteriophage consisting of the nucleotide sequence of any one of SEQ ID NO: 1 and 3 to 7.

4. The composition of claim 1, comprising any one of the following bacteriophage mixtures: i) P1777 + P1797 + P1940 + P1384; ii) P1777 + P1792 + P1797 + P1800 + P1384; iii) P1777 + P1792 + P1797 + P1800 + P1902 + P1384; iv) P1777 + P1792 + P1797 +P1800 + P1902 + P1940 + P1384; Among them, P1384, P1777, P1792, P1797, P1800, P1902, and P1940 refer to bacteriophages with lytic activity against Pseudomonas aeruginosa strains, and the genomes of the bacteriophages are composed of the nucleotide sequences of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, and SEQ ID NO: 7, respectively.

5. The composition of claim 1, comprising: A bacteriophage with lytic activity against Pseudomonas aeruginosa strains, wherein the genome of the bacteriophage consists of the nucleotide sequence of SEQ ID NO: 1; A bacteriophage with lytic activity against Pseudomonas aeruginosa strains, wherein the genome of the bacteriophage consists of the nucleotide sequence of SEQ ID NO: 2; A bacteriophage with lytic activity against Pseudomonas aeruginosa strains, wherein the genome of the bacteriophage consists of the nucleotide sequence of SEQ ID NO: 3; A bacteriophage with lytic activity against Pseudomonas aeruginosa strains, wherein the genome of the bacteriophage consists of the nucleotide sequence of SEQ ID NO: 4; A bacteriophage with lytic activity against Pseudomonas aeruginosa strains, wherein the genome of the bacteriophage consists of the nucleotide sequence of SEQ ID NO: 5; A bacteriophage with lytic activity against *Pseudomonas aeruginosa* strains, wherein the genome of the bacteriophage consists of the nucleotide sequence of SEQ ID NO: 6; and A bacteriophage with lytic activity against Pseudomonas aeruginosa strains, wherein the genome of the bacteriophage consists of the nucleotide sequence of SEQ ID NO:

7.

6. The composition of any one of claims 1 to 5, which is lytic to antibiotic-resistant Pseudomonas aeruginosa strains.

7. The composition of any one of claims 1 to 5, which is lytic to more than 90% of the bacterial strains in all bacterial strains at the LMG collection.

8. The composition of any one of claims 1 to 5, further comprising a pharmaceutically acceptable excipient or carrier.

9. The composition of any one of claims 1 to 5, wherein it is a liquid, semi-liquid, solid or lyophilized formulation.

10. The composition of any one of claims 1 to 5, comprising 10 e4 Up to 10 e12 Each phage between PFUs.

11. Use of the composition of any one of claims 1 to 10 in the preparation of a medicament for treating Pseudomonas aeruginosa infection in mammals.

12. The use of claim 11, wherein the infection is a respiratory infection.

13. Use of the composition of any one of claims 1 to 10 in the preparation of a medicament for improving the condition of a mammal by modifying the microbial flora in a mammal infected with Pseudomonas aeruginosa.

14. Use of the composition of any one of claims 1 to 10 for disinfecting materials contaminated with Pseudomonas aeruginosa.

15. A method for preparing a composition according to any one of claims 1 to 10, the method comprising separately producing the at least two phages and combining the phages with a suitable carrier or excipient.

16. A bacteriophage having lytic activity against strains of Pseudomonas aeruginosa, and whose genome consists of the nucleotide sequence of SEQ ID NO:

2.

17. An isolated nucleic acid consisting of the nucleotide sequence of SEQ ID NO:

2.

18. Use of the bacteriophage of claim 16 or the nucleic acid of claim 17 in the preparation of a medicament for treating Pseudomonas aeruginosa infection in mammals.

19. Use of the bacteriophage of claim 16 or the nucleic acid of claim 17 in the preparation of a medicament for improving the condition of a mammal by modifying the microbial flora in a mammal infected with Pseudomonas aeruginosa.

20. Use of the bacteriophage of claim 16 or the nucleic acid of claim 17 for disinfection of materials contaminated with Pseudomonas aeruginosa.

Images