Multichannel two-dimensional chromatograph and method for two-dimensional chromatographic separation

A two-dimensional chromatography and chromatographic separation technology, which is applied to multi-channel two-dimensional chromatography and used in the field of two-dimensional chromatography separation, can solve the problem that it is difficult to meet the needs of complex sample separation, cannot be directly used for component separation and preparation, and the length of the two-dimensional separation column is short. and other problems, to achieve the effect of improving the separation effect, choosing a variety of types, and wide applicability

CN107449839AActive Publication Date: 2017-12-08山东聊和环保科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2017-12-08

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Abstract

The invention discloses a multichannel two-dimensional chromatograph and a method for two-dimensional chromatographic separation. The multichannel two-dimensional chromatograph consists of a one-dimensional chromatographic separation system and a multichannel two-dimensional chromatographic separation system, wherein the one-dimensional chromatographic separation system consists of a one-dimensional chromatographic flowing phase liquid accumulator M, a one-dimensional chromatographic high-pressure pump P, a one-dimensional chromatographic sample valve V, a one-dimensional chromatographic column C and a one-dimensional chromatographic detector D; the multichannel two-dimensional chromatographic separation system consists of multiple two-dimensional chromatographic flowing phase liquid accumulators M1 to M8, multiple two-dimensional chromatographic high-pressure pumps P1 to P8, multiple two-dimensional chromatographic columns C1 to C8, multiple two-dimensional chromatographic detectors D1 to D8 and a fraction collector. The multichannel two-dimensional chromatograph and the method are high in separation efficiency and practicability, and particularly applied to all-component separation of complex systems such as traditional Chinese medicaments and body fluids and separation of difficult-to-separate substances such as structurally similar compounds.
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Description

technical field

[0001] The application relates to a multi-channel two-dimensional chromatographic instrument and a method for two-dimensional chromatographic separation, belonging to the technical field of instrument and equipment manufacturing, and is a high-efficiency chromatographic separation and analysis device. Background technique

[0002] The chromatographic method has the characteristics of high efficiency, rapidity and wide application. It has developed into a key technology to solve various separation and analysis problems in the research of organic substances. It is widely used in the fields of pharmacy, life science, medicine, food science, petrochemical industry and environmental protection. be widely used. The usual chromatograph is composed of mobile phase storage, mobile phase pump, sample injector, chromatographic column, detector, recorder, etc. During the application process, a chromatographic column is often used for separation, that is, one-dimensional ...

Examples

Embodiment 1

[0031] Example 1 as figure 1 As shown, a multi-channel two-dimensional chromatograph and a method for two-dimensional chromatographic separation, the multi-channel two-dimensional chromatograph is composed of a one-dimensional chromatographic separation system and a multi-channel two-dimensional chromatographic separation system, and the one-dimensional chromatographic separation system consists of a One-dimensional chromatographic mobile phase reservoir M, one-dimensional chromatographic high-pressure pump P, one-dimensional chromatographic injection valve V, one-dimensional chromatographic column C and one-dimensional chromatographic detector D, the two-dimensional chromatographic separation system consists of multiple two-dimensional chromatographic Composed of mobile phase reservoirs M1 to M8, multiple two-dimensional chromatography high-pressure pumps P1 to P8, multiple two-dimensional chromatography columns C1 to C8, multiple two-dimensional chromatography detectors D1 to...