Method for improving grain sizes of mannitol crystals

A technology of mannitol and crystals, which is applied in the field of increasing the grain size of mannitol crystals, which can solve the problems of uneven crystal grains, small grain size, and low purity, and achieve the effect of high crystal purity, uniform crystal grain size, and uniform crystal grain size

CN107698427AInactive Publication Date: 2018-02-16山西卓联锐科科技有限公司
3 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
Publication Date
2018-02-16
Estimated Expiration
Not applicable · inactive patent
Patent Text Reader

Abstract

The invention relates to a method for improving grain sizes of mannitol crystals, and belongs to the technical field of mannitol crystallization. The method mainly solves the technical problems that crystal particles are uniform, grain sizes are small and purity is low existing in a mannitol crystallization process. The technical scheme of the method is as follows: the method for improving the grain sizes of the mannitol crystals comprises the following steps: 1) determining an added amount of seed crystals; 2) performing feeding: connecting a double-layer crystallizer with a circulating waterbath, and after the temperature of the water bath is raised to 80 DEG C, adding liquid mannitol into the double-layer crystallizer, performing mechanical stirring to obtain a mannitol solution, wherein the stirring speed is 80r / min; 3) performing cooling for crystallization: adding the seed crystals into the mannitol solution, performing temperature raising and cooling repeatedly for 15-20 times,wherein the final temperature of each cooling is decreased continuously and gradually close to 20 DEG C; and 4) performing cleaning and performing drying. The method provided by the invention has theadvantages that the operation is simple, the grain sizes are large and uniform and the like.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the technical field of mannitol crystallization, and in particular relates to a method for increasing the grain size of mannitol crystallization. Background technique

[0002] Mannitol is a kind of hexanehexyl alcohol, because it absorbs heat when dissolved, has a sweet taste, and has a comfortable feeling to the mouth, so it is more widely used in the manufacture of chewable tablets such as hangover medicines and mouth fresheners. Its granule type is specially used for direct compression excipients. Mannitol is a hypertonic tissue dehydrating agent, which is widely used clinically to treat cerebral edema, prevent acute renal failure, treat glaucoma, and accelerate the excretion of poisons and drugs from the kidneys.

[0003] The crystals obtained in the existing mannitol crystallization process have more crystal nuclei formed in the early stage of growth, so that the growth space is limited, the crystal growth rate is slow, a...

Examples

Embodiment 1

[0015] A method for improving the crystal size of mannitol crystals in the present embodiment comprises the following steps:

[0016] 1) Determine the amount of seed crystal added: according to the formula Ms=(Ls / La) 3 Ma calculates the addition amount of crystal seed, and Ms represents the quality of crystal seed in the formula; Ls represents the particle size of crystal seed; La represents the particle size of target crystal; Three times, the solution is 270Kg, and the yield is 50%, so Ma=270×50%=135Kg, Ls / La=1 / 3, then the addition Ms=(1 / 3)3×135=5Kg of crystal seed ;

[0017] 2) Feeding: connect the double-layer crystallizer to a circulating water bath, and when the temperature of the water bath rises to 80°C, add liquid mannitol into the double-layer crystallizer and perform mechanical stirring to prepare a mannitol solution at a stirring rate of 80r / min;

[0018] 3) Cooling crystallization: add the corresponding amount of seed crystals calculated in step 1) to the mannit...

Embodiment 2

[0021] A method for improving the crystal size of mannitol crystals in the present embodiment comprises the following steps:

[0022] 1) Determine the amount of seed crystal added: according to the formula Ms=(Ls / La) 3 Ma calculates the addition amount of crystal seed, and Ms represents the quality of crystal seed in the formula; Ls represents the particle size of crystal seed; La represents the particle size of target crystal; Three times, the solution is 270Kg, and the yield is 50%, so Ma=270×50%=135Kg, Ls / La=1 / 3, then the addition Ms=(1 / 3)3×135=5Kg of crystal seed ;

[0023] 2) Feeding: connect the double-layer crystallizer to a circulating water bath, and when the temperature of the water bath rises to 80°C, add liquid mannitol into the double-layer crystallizer and perform mechanical stirring to prepare a mannitol solution at a stirring rate of 80r / min;

[0024] 3) Cooling crystallization: add the corresponding amount of seed crystals calculated in step 1) to the mannit...

Embodiment 3

[0027] A method for improving the crystal size of mannitol crystals in the present embodiment comprises the following steps:

[0028] 1) Determine the amount of seed crystal added: according to the formula Ms=(Ls / La) 3 Ma calculates the addition amount of crystal seed, and Ms represents the quality of crystal seed in the formula; Ls represents the particle size of crystal seed; La represents the particle size of target crystal; Three times, the solution is 270Kg, and the yield is 50%, so Ma=270×50%=135Kg, Ls / La=1 / 3, then the addition Ms=(1 / 3)3×135=5Kg of crystal seed ;

[0029] 2) Feeding: connect the double-layer crystallizer to a circulating water bath, and when the temperature of the water bath rises to 80°C, add liquid mannitol into the double-layer crystallizer and perform mechanical stirring to prepare a mannitol solution at a stirring rate of 80r / min;

[0030] 3) Cooling crystallization: add the corresponding amount of seed crystals calculated in step 1) to the mannit...