Glue delivery system and preparation method

Abstract

A glue liquid conveying system and a preparation method thereof, the glue liquid conveying system comprising: a glue tank, a compressed air pipeline, a glue liquid outflow pipeline, a first glue box and a second glue box, a first liquid level sensor and a second liquid level sensor, and a first pneumatic control valve and a second pneumatic control valve.

Description

Technical Field

[0001] The present invention relates to the field of pharmaceutical equipment, in particular to a glue delivery system and a preparation method for delivering glue from a glue chemical tank to a glue distributor of a pill making machine, and in particular to a glue delivery system for soft capsule pill making equipment. Background Art

[0002] like Figure 1 As shown, generally, the glue liquid conveying system for soft capsule pill making equipment includes: a glue chemical tank 1, a glue box 5, a glue supply pump 7 and a control cabinet 9; the glue chemical tank 1 is used to store glue liquid; the glue supply pump 7 is used to supply the glue liquid from the glue chemical tank 1 to the glue box 5 via a pipeline; the glue box 5 is used to receive the glue liquid from the glue chemical tank 1; and the control cabinet 9 is used to control the operation of the glue supply pump 7.

[0003] The pipeline connecting the glue tank 1, the glue supply pump 7 and the glue box 5 is provided with a pipeline heater 3, which is used to heat the glue liquid in the pipeline to prevent the glue liquid from solidifying due to temperature drop when it does not flow for a long time, thereby affecting product quality.

[0004] A liquid level sensor 4 is provided in the glue box 5. The liquid level sensor 4 is used to detect the height of the liquid level in the glue box 5, and output different signals to the control cabinet 9 according to the height of the liquid level.

[0005] A programmable logic controller (PLC) is disposed in the control cabinet 9 . The PLC receives a signal from the liquid level sensor 4 , and controls the frequency of the frequency converter based on the received signal, thereby controlling the rotation speed of the glue supply pump 7 .

[0006] However, according to the above-mentioned prior art, there are many components and control elements in the system, which will increase the manufacturing cost of the system and require space to separately install a control cabinet.

[0007] In addition, due to process reasons, the glue pipeline needs to be heated and insulated throughout the process. Since the glue pipeline controlled by the system is long, at least 5 sets of heaters are required, and there is no heater suitable for heating the glue supply pump. When the equipment is shut down and the glue does not flow for a long time, the glue temperature in the glue supply pump will drop, which may cause solidification and affect product quality.

[0008] In addition, at the final stage of a single batch of production, since the glue liquid will lose power after completely passing through the glue supply pump, a large amount of glue liquid will remain inside the glue supply pump and in the subsequent pipelines. For these unusable glue liquids, they can only be washed away with cleaning water when cleaning the pipeline. This will cause a large waste of raw materials, thereby increasing the production cost of the enterprise.

[0009] In addition, since there are dead corners in the cavity of the glue supply pump, the glue supply pump needs to be disassembled and cleaned each time it is cleaned, which increases the cleaning time.

[0010] In addition, when the glue in the glue tank is about to be used up, the equipment is shut down and the glue will flow back, causing air to enter the pipeline. This air will rush into the glue box when the machine is started again, thereby increasing the risk of product quality. Summary of the invention

[0011] In order to solve the above problems and / or other problems arising in the related technical field, the present invention is dedicated to providing a glue liquid delivery system and preparation method. The system supplies glue liquid from the glue tank to the glue box by compressed air based on the detection signal of the liquid level sensor, so that all the glue liquid in the system can be supplied to the glue box, and the amount of glue liquid in the glue box can be easily controlled.

[0012] According to one aspect of the present invention, a glue liquid conveying system is provided, which may include: a glue chemical tank, which is used to store glue liquid; a compressed air pipeline, which is connected to the glue chemical tank and supplies pure compressed air to the glue chemical tank; a glue liquid outflow pipeline, one end of which is connected to the bottom of the glue chemical tank, and the other end is bifurcated into a first branch and a second branch; a first glue box and a second glue box, the first glue box is connected to the glue chemical tank through the first branch of the glue liquid outflow pipeline, and the second glue box is connected to the glue chemical tank through the second branch of the glue liquid outflow pipeline, so that the first glue box and the second glue box receive glue liquid from the glue chemical tank; a first liquid level sensor and a second liquid level sensor, the first liquid level sensor is arranged in the first glue box, and the second liquid level sensor is arranged in the second glue box, respectively used to detect the liquid levels of the glue liquid in the first glue box and the second glue box; a first pneumatic control valve and a second pneumatic control valve, the first pneumatic control valve is arranged in the first branch, and is opened or closed according to the output signal of the first liquid level sensor, and the second pneumatic control valve is arranged in the second branch, and is opened or closed according to the output signal of the second liquid level sensor.

[0013] When the first liquid level sensor detects that the glue level in the first glue box is greater than the first predetermined value, the first pneumatic control valve can be closed, and the glue in the glue chemical tank cannot flow from the glue chemical tank to the first glue box through the glue outflow pipe; when the second liquid level sensor detects that the glue level in the second glue box is greater than the first predetermined value, the second pneumatic valve can be closed, and the glue in the glue chemical tank cannot flow from the glue chemical tank to the second glue box through the glue outflow pipe; when the first liquid level sensor detects that the glue level in the first glue box is less than the second predetermined value, the first pneumatic control valve can be opened, and the glue in the glue chemical tank can flow from the glue chemical tank to the first glue box through the glue outflow pipe; when the second liquid level sensor detects that the glue level in the second glue box is less than the second predetermined value, the second pneumatic valve can be opened, and the glue in the glue chemical tank can flow from the glue chemical tank to the second glue box through the glue outflow pipe.

[0014] The first pneumatic control valve may include: a first solenoid valve that operates according to an output signal of a first liquid level sensor; and a first pneumatic valve that opens or closes according to the operation of the first solenoid valve.

[0015] The second pneumatic control valve may include: a second solenoid valve that operates according to an output signal of a second liquid level sensor; and a second pneumatic valve that opens or closes according to the operation of the second solenoid valve.

[0016] In addition, the glue delivery system may include a first button switch, which is used to control the controlled state of the glue delivery system. When the first switch button is pressed, the system is in a manual control state. When the first switch button is in a reset state, the system is in an automatic control state.

[0017] In addition, the glue delivery system may include a second button switch. When the system is in manual control, when the second switch button is pressed, the glue cannot flow from the glue tank to the first glue box and the second glue box. When the second switch button is in a reset state, the glue can flow from the glue tank to the first glue box and the second glue box.

[0018] In addition, the glue liquid conveying system may include a pipeline heater, which is sleeved on the outside of the glue liquid outflow pipeline and is used to heat the glue liquid in the glue liquid outflow pipeline.

[0019] In addition, the glue delivery system may include a pressure reducing valve, which is arranged between the compressed air pipeline and the glue tank to adjust the pressure in the glue tank.

[0020] In addition, the glue delivery system may include an upper process valve, which is arranged in the glue outflow pipeline and located between the glue tank and the pneumatic control valve. The upper process valve controls whether the glue can flow out of the glue tank according to the signal of the upper process.

[0021] In addition, the glue liquid conveying system may include a pill making machine, which is arranged below the glue box to receive the glue liquid flowing out of the glue box.

[0022] According to another aspect of the present invention, a method for preparing a pharmaceutical preparation is also provided, which may include using the aforementioned glue delivery system to supply glue containing active pharmaceutical ingredients, followed by the steps of glue spreading, cooling, skin lifting, and pilling. Preferably, the pharmaceutical preparation is a soft capsule preparation.

[0023] Furthermore, the active pharmaceutical ingredient can be selected from butylphthalide, safinamide, febuxostat, minodronic acid, apremilast, trelagliptin, liquid calcium, vitamin E, fish oil (rich in ω-3 polyunsaturated fatty acids, such as DHA (docosahexaenoic acid), EPA (eicosapentaenoic acid) or a mixture thereof, and derivatives of DHA or EPA), AD calciferol, dutasteride, paricalcitol, daptomycin, orivacin, clindamycin, paroxetine, ulipristal, pramipexole, eltradefylline, henggliflozin, fendapalu, caspofungin, and abiraterone.

[0024] According to the glue delivery system of the present invention, all the glue in the system can be supplied to the glue box, and the amount of glue in the glue box can be easily controlled, thereby reducing the manufacturing cost of the system and simplifying the structure. There is no residual glue in the system, which is easy to clean, maximizes material utilization, and saves pre-production preparation and post-production cleaning time. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] The above and other objects, features and advantages of the present invention will become more clearly understood from the following detailed description when presented in conjunction with the accompanying drawings, in which:

[0026] Figure 1 The schematic diagram of the glue liquid conveying system of the fully automatic pill making equipment in the prior art is shown;

[0027] Figure 2 A schematic diagram showing a glue delivery system according to the present invention;

[0028] Figure 3 A schematic diagram of control elements of the glue delivery system according to the present invention is schematically shown. DETAILED DESCRIPTION

[0029] The following will be referred to in detail various embodiments of the present invention, examples of which are shown in the accompanying drawings and described below. Although the present invention will be described in conjunction with the exemplary embodiments, it should be understood that this specification is not intended to limit the present invention to those exemplary embodiments. On the contrary, the present invention is intended to not only cover these exemplary embodiments, but also to cover various alternative forms, modified forms, equivalent forms and other embodiments that may be included in the spirit and scope of the present invention as defined by the appended claims.

[0030] Figure 2 Schematic diagram of a glue delivery system according to various embodiments of the present invention. Figure 2 The glue delivery system may include: a glue tank 100, a compressed air pipeline 900, a glue outflow pipeline 1100, a glue box 500, a liquid level sensor 400 and a pneumatic control valve 300.

[0031] The glue tank 100 can store glue. The top of the glue tank 100 can be connected to the compressed air pipeline 900, and the bottom of the glue tank 100 can be connected to the first end of the glue outflow pipeline 1100. The glue tank 100 can be formed into shapes such as cylinders, cuboids, cubes, etc., but is not limited to this. In addition, the glue tank 100 can be made of metal (for example, 316L stainless steel), but is not limited to this.

[0032] When compressed air flows into the glue tank 100 from the compressed air pipe 900, the pressure in the glue tank 100 increases, and when the pressure in the glue tank 100 is greater than the external pressure, the glue flows out through the glue outflow pipe 1100. In particular, during operation, the pressure in the glue tank 100 is about 50Pa to 150Pa, preferably 80Pa.

[0033] The compressed air pipeline 900 connects the glue tank 100 with the supply tank for supplying compressed air, and is used to supply pure compressed air to the glue tank 100. The compressed air pipeline 900 is made of metal or plastic (for example, 316L stainless steel) and has a circular cross-section, but is not limited thereto. In addition, the pressure of the compressed air in the compressed air pipeline 900 is about 50Pa to 150Pa, preferably 80Pa.

[0034] Glue outflow pipeline 1100 connects the glue tank 100 with the glue box 500 (for example, welding, plugging, etc.), so that the glue in the glue tank 100 can flow to the glue box 500. The first end of the glue outflow pipeline 1100 is connected to the bottom of the glue tank 100, and the other end of the glue outflow pipeline 1100 is bifurcated into a first branch 1101 and a second branch 1102. The glue outflow pipeline 1100 can have a circular cross section, but can also have other shapes (for example, rectangle, etc.). The glue outflow pipeline 1100 is made of metal material (for example, 316L stainless steel), and this metal material can be the same as the material made of the glue tank 1, or can also be different from the material made of the glue tank 1. The glue box 500 is arranged at the glue outflow pipeline 1100, and is located at the downstream of the glue tank 100, and is used to receive the glue from the glue tank 100, and the glue is supplied to the pill making machine 600 to make capsules.

[0035] Preferably, the glue box 500 may include a first glue box 510 and a second glue box 520, the first glue box 510 is connected to the glue tank 100 through a first branch 1101 branched off from the second end of the glue outflow pipe 1100, and the second glue box 520 is connected to the glue tank through a second branch 1102 branched off from the second end of the glue outflow pipe 1100.

[0036] like Figure 2 As shown, the first glue box 510 is a cylinder at the top and an inverted cone at the bottom; the top of the cylinder has an inlet to allow the glue to flow in; the bottom of the inverted cone (the end closest to the pill making machine) has an outlet to allow the glue to flow out. The first glue box 510 is made of copper or stainless steel, preferably copper.

[0037] In a preferred embodiment of the present application, the second plastic box 520 may have the same shape as the first plastic box 510 . Of course, in other embodiments, it may have a different shape, and the second plastic box 520 may be made of the same or different material as the first plastic box 510 .

[0038] The liquid level sensor 400 is disposed on the glue box 500 and is electrically connected to the pill making machine control cabinet 700 . The liquid level sensor 400 is used to detect the liquid level of the glue in the glue box 500 and transmit the sensing signal to the pill making machine controller 700 .

[0039] Preferably, the liquid level sensor 400 may include a first liquid level sensor 410 and a second liquid level sensor 420 .

[0040] The first liquid level sensor 410 is disposed in the first glue box 510, and can detect the amount of glue in the first glue box 510, and transmit the detected signal related to the amount of glue to the pill making machine control cabinet 700. Specifically, when the first liquid level sensor 410 detects that the glue level in the first glue box 510 is greater than a first predetermined level, the first signal is output to the pill making machine control cabinet 700; when the first liquid level sensor 410 detects that the glue level in the first glue box 510 is less than a second predetermined level, the second signal is output to the pill making machine control cabinet 700.

[0041] Here, the first liquid level sensor 410 is not limited thereto, but may include any sensor (eg, an inductive sensor) capable of measuring the amount of glue in the first glue box 510 .

[0042] The second liquid level sensor 420 is similar to the first liquid level sensor 410 and will not be described again. In addition, the second liquid level sensor 420 may be a sensor of a different type from the first liquid level sensor 410 .

[0043] The pneumatic control valve 300 is disposed in the glue outflow pipe 1100 and is located between the glue tank 100 and the glue box 500. The pneumatic control valve 300 receives the output signal from the liquid level sensor 400 and is opened or closed according to the output signal of the liquid level sensor 400. According to the opening or closing of the pneumatic control valve 300, the liquid level of the glue in the glue box 500 can be maintained at a certain level, thereby ensuring that the glue flowing out of the glue box 500 has an appropriate and stable flow rate.

[0044] Preferably, the pneumatic control valve 300 may include a first pneumatic control valve 310 and a second pneumatic control valve 320. The first pneumatic control valve 310 will be described in detail below.

[0045] The first pneumatic control valve 310 is disposed in the first branch 1101 of the glue outflow pipeline 1100 and is located downstream of the glue tank. When the first pneumatic control valve 310 receives a first signal from the liquid level sensor 400, the first pneumatic control valve 310 is closed, and the glue in the glue outflow pipeline 1100 cannot flow to the first glue box 510; when the first pneumatic control valve 310 receives a second signal from the liquid level sensor 400, the first pneumatic control valve 310 is opened, and the glue in the glue outflow pipeline 1100 cannot flow to the first glue box 510.

[0046] In other words, when there is too much glue in the first glue box 510, the first pneumatic control valve 310 is closed to prevent the glue in the glue outflow pipe 1100 from continuing to flow to the first glue box 510; when there is too little glue in the first glue box 510, the first pneumatic control valve 310 is opened to allow the glue in the glue outflow pipe 1100 to flow to the first glue box 510.

[0047] The first pneumatic control valve 310 may include a first solenoid valve 311 and a first pneumatic valve 312, and the first pneumatic valve 312 is opened or closed according to the operation of the first solenoid valve 311. It should be understood that the first pneumatic control valve 310 is not limited thereto, but includes various control valves capable of realizing a fluid blocking function.

[0048] The second pneumatic control valve 320 is similar to the first pneumatic control valve 310 , and thus will not be described in detail. It should be noted that the pneumatic control valve 320 may be a different type of control valve than the first pneumatic control valve 310 .

[0049] Furthermore, the glue delivery system may include a pill making machine 600 , which may be disposed below the glue box 500 to receive the glue from the glue box 500 .

[0050] Further, the glue delivery system may include an upper process valve 200, which is disposed in the glue outflow pipe 1100 and is located between the pneumatic control valve 500 and the glue tank 100. The upper process valve 200 may be opened or closed according to the quality of the glue in the glue tank 100, for example, to ensure the quality of the glue.

[0051] Specifically, for example, when the quality of the glue liquid in the glue tank 100 reaches the standard, the upper process controls the upper process valve 200 to be open, and when the quality of the glue liquid in the glue tank 100 does not reach the standard, the upper process controls the upper process valve 200 to be closed.

[0052] Furthermore, the glue delivery system may include a pipe heater 800, which is sleeved on the glue outflow pipe 1100, so as to heat the glue in the glue outflow pipe 1100 to prevent the glue from solidifying and affecting the product quality. Specifically, the pipe heater 800 is at a temperature of about 55-65°C, preferably 60°C, during operation.

[0053] Preferably, only one pipe heater 800 may be disposed in the glue outflow pipe 1100 . However, the present invention is not limited thereto, and a plurality of pipe heaters 800 may also be disposed in the glue outflow pipe 1100 .

[0054] Furthermore, the glue delivery system may include a pressure reducing valve 1000, which is disposed in the compressed air pipeline 900 and is opened or closed according to the pressure in the glue tank 100, thereby maintaining the pressure in the glue tank 100 within a certain range. The pressure reducing valve 1000 may be manually controlled or automatically controlled.

[0055] Figure 3 Schematic diagram of control elements of a glue delivery system according to various embodiments of the present invention.

[0056] refer to Figure 3The control elements of the glue delivery system may include: a solenoid valve coil KM, an intermediate relay KA, a first switch SB1 and a second switch SB2.

[0057] Preferably, the solenoid valve coil KM includes a first solenoid valve coil KM1 and a second solenoid valve coil KM2, and the intermediate relay KA includes a first intermediate relay KA1 and a second intermediate relay KA2. The operation of the first solenoid valve coil KM1 and the first intermediate relay KA1 will be described in detail below.

[0058] like Figure 3 As shown, the first switch SB1 is a self-locking button switch, which is used to control the glue delivery control system to be in automatic control or manual control. Specifically, when the first switch SB1 is pressed, the glue delivery control system is in automatic control state, and when the first switch SB1 is in reset state, the glue delivery control system is in manual control state.

[0059] When the glue delivery control system is in the automatic control state, the pneumatic control valve 300 is controlled according to the sensing signal of the liquid level sensor 400. Specifically, when the first switch SB1 is pressed, the normally closed contact of SB1 is disconnected and the normally open contact is turned on, and the liquid level sensor 400 is powered on. Preferably, the liquid level sensor 400 is a PNP type sensor.

[0060] In this case, when the first liquid level sensor 410 detects that the liquid level in the first glue box 510 is greater than the first predetermined value, the first liquid level sensor 410 outputs a high level to turn on the coil in the first intermediate relay KA1, so that the normally open contact of the first intermediate relay KA1 is closed, thereby energizing the first solenoid valve coil KM1, actuating the first solenoid valve 311, and closing the first pneumatic valve 312, thereby closing the first pneumatic control valve 310 and stopping the glue supply.

[0061] When the first liquid level sensor 410 detects that the liquid level in the first glue box 510 is less than the second predetermined value, the first liquid level sensor 410 outputs a low level to disconnect the coil in the first intermediate relay KA1, so that the normally open contact of the first intermediate relay KA1 is disconnected, thereby de-energizing the first solenoid valve coil KM1, and the first solenoid valve 311 does not operate, and the pneumatic valve 312 opens, thereby opening the first pneumatic control valve 310 to start supplying glue.

[0062] When the glue delivery system is in manual control, the first pneumatic control valve 310 is controlled according to the operation of the second switch SB2. Specifically, when the first switch SB1 is in reset state, the normally closed contact of SB1 is closed and the normally open contact is disconnected, and the liquid level sensor 400 is powered off.

[0063] In this case, when the second switch SB2 is pressed, its normally open contact closes, so that the solenoid valve coil KM is energized, so that the first solenoid valve 311 and the second solenoid valve 321 are actuated, and the first pneumatic valve 312 and the second starting valve 322 are closed, thereby closing the pneumatic control valve 300 and stopping the glue supply.

[0064] When the second switch SB2 is in the reset state, its normally open contact is disconnected, so that the solenoid valve coil KM loses power, so that the first solenoid valve 311 and the second solenoid valve 321 do not operate, the first pneumatic valve 312 and the second starting valve 322 are opened, and the pneumatic control valve 300 is opened to start supplying glue.

[0065] It should be understood that the control system in the present invention is not limited to this, but includes all combinations of various electrical components that can achieve this control.

[0066] The glue delivery system according to various embodiments of the present invention can be used to prepare pharmaceutical preparations. Therefore, the present invention also provides a method for preparing a pharmaceutical preparation, which uses the glue delivery system to supply glue containing active pharmaceutical ingredients.

[0067] Specifically, under the control of the pill making machine control cabinet 700, the glue liquid containing the active pharmaceutical ingredient stored in the glue tank 100 passes through the upper process valve 200, the first pneumatic control valve 310 and the second pneumatic control valve 320 and is supplied to the first glue box 510 and the second glue box 520 respectively, so that the glue liquid containing the active pharmaceutical ingredient is supplied to the pill making machine 600, and then the steps of glue spreading, cooling, skin pulling, pill making, etc. are carried out.

[0068] Preferably, the pharmaceutical preparation can be a soft capsule preparation. However, the pharmaceutical preparation is not limited thereto and can also be other types of pharmaceutical preparations.

[0069] In addition, the active pharmaceutical ingredient may be butylphthalide, safinamide, febuxostat, minodronic acid, apremilast, trelagliptin, liquid calcium, vitamin E, fish oil (rich in ω-3 polyunsaturated fatty acids, such as DHA (docosahexaenoic acid), EPA (eicosapentaenoic acid) or a mixture thereof, and a derivative of DHA or EPA), AD calciferol, dutasteride, paricalcitol, daptomycin, olivancin, clindamycin, paroxetine, ulipristal, pramipexole, edradefylline, henggliflozin, fendapalu, caspofungin, abiraterone. However, the active pharmaceutical ingredient is not limited thereto, and may also be other types of active pharmaceutical ingredients.

[0070] Obvious changes may be made in the specific embodiments of the invention described herein, such modifications falling within the spirit and scope of the invention as claimed.It should be noted that all matters contained herein are illustrative and not limiting the scope of the invention.

Claims

1. A glue delivery system, characterized in that: include: A glue tank, which is used to store glue liquid; A compressed air pipeline connected to the glue tank and supplying pure compressed air to the glue tank, the compressed air pipeline connecting the glue tank with a supply tank for supplying compressed air; The glue liquid outflow pipe has one end connected to the bottom of the glue tank and the other end bifurcated into a first branch and a second branch; A first glue box and a second glue box, wherein the first glue box is connected to the glue tank through a first branch of the glue outflow pipe, and the second glue box is connected to the glue tank through a second branch of the glue outflow pipe, so that the first glue box and the second glue box receive glue from the glue tank; A first liquid level sensor and a second liquid level sensor, wherein the first liquid level sensor is disposed in the first glue box, and the second liquid level sensor is disposed in the second glue box, and are used to detect the liquid levels of the glue in the first glue box and the second glue box respectively; a first pneumatic control valve and a second pneumatic control valve, wherein the first pneumatic control valve is arranged in the first branch and is opened or closed according to an output signal of the first liquid level sensor, and the second pneumatic control valve is arranged in the second branch and is opened or closed according to an output signal of the second liquid level sensor; A first button switch, which is used to control the controlled state of the glue delivery system. When the first switch button is pressed, the system is in a manual control state. When the first switch button is in a reset state, the system is in an automatic control state. The second button switch, when the system is in manual control state, when the second switch button is pressed, the glue cannot flow from the glue tank to the first glue box and the second glue box. When the second switch button is in the reset state, the glue can flow from the glue tank to the first glue box and the second glue box.

2. The glue delivery system according to claim 1, characterized in that: When the first liquid level sensor detects that the glue liquid level in the first glue box is greater than the first predetermined value, the first pneumatic control valve is closed, and the glue liquid in the glue tank cannot flow from the glue tank to the first glue box through the glue liquid outflow pipe; When the second liquid level sensor detects that the glue liquid level in the second glue box is greater than the first predetermined value, the second pneumatic valve is closed, and the glue liquid in the glue tank cannot flow from the glue tank to the second glue box through the glue liquid outflow pipe; When the first liquid level sensor detects that the glue liquid level in the first glue box is less than the second predetermined value, the first pneumatic control valve is opened, and the glue liquid in the glue tank can flow from the glue tank to the first glue box through the glue liquid outflow pipe; When the second liquid level sensor detects that the glue liquid level in the second glue box is less than the second predetermined value, the second pneumatic valve opens, and the glue liquid in the glue tank can flow from the glue tank to the second glue box through the glue liquid outflow pipe.

3. The glue delivery system according to claim 1, characterized in that: The first pneumatic control valve comprises: a first solenoid valve operated according to an output signal of the first liquid level sensor; The first pneumatic valve is opened or closed according to the operation of the first solenoid valve.

4. The glue delivery system according to claim 1, characterized in that: The second pneumatic control valve comprises: a second solenoid valve operated according to an output signal of the second liquid level sensor; The second pneumatic valve is opened or closed according to the operation of the second solenoid valve.

5. The glue delivery system according to claim 1, characterized in that: It further comprises a pipeline heater, which is sleeved on the outside of the glue outflow pipeline and is used for heating the glue in the glue outflow pipeline.

6. The glue delivery system according to claim 1, characterized in that: It further comprises a pressure reducing valve which is arranged between the compressed air pipeline and the glue tank to adjust the pressure in the glue tank.

7. The glue delivery system according to claim 1, characterized in that: It further comprises an upper process valve, which is arranged in the glue liquid outflow pipeline and is located between the glue tank and the pneumatic control valve. The upper process valve controls whether the glue liquid can flow out of the glue tank according to the signal of the upper process.

8. The glue delivery system according to claim 1, characterized in that: The device further comprises a pill-making machine which is arranged below the glue box to receive the glue liquid flowing out of the glue box.

9. A method for preparing a pharmaceutical preparation, comprising supplying a glue solution containing a pharmaceutically active ingredient using the glue solution delivery system according to any one of claims 1 to 8.

10. The preparation method according to claim 9, characterized in that: The active pharmaceutical ingredient is selected from butylphthalide, safinamide, febuxostat, minodronic acid, apremilast, trelagliptin, liquid calcium, vitamin E, fish oil, AD calciferol, dutasteride, paricalcitol, daptomycin, orivacin, clindamycin, paroxetine, ulipristal, pramipexole, edradefylline, henggliflozin, fendapalu, caspofungin, and abiraterone.

11. The preparation method according to claim 9, characterized in that: The pharmaceutical preparation is a soft capsule pharmaceutical preparation.

Images