An automatic platelet antibody detection device
By designing a fully automatic platelet antibody detection device, the process of reagent distribution and sample distribution in platelet antibody detection is fully automated, and the problems of low detection efficiency and error prone in the existing technology are solved, and the detection efficiency and accuracy are improved.
Patent Information
- Application Number
- CN201910508695.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2019-06-13
- Publication Date
- 2025-06-24
- Estimated Expiration
- 2039-06-13
AI Technical Summary
The existing platelet antibody detection technology mainly relies on manual or semi-automatic operation, and cannot achieve full automation, resulting in low detection efficiency and error-prone.
A fully automatic platelet antibody detection device is designed, including an outer ring turntable device, centrifuge, incubation module, heat dissipation module, sample loading arm module and interpretation camera to fully automate the processes of reagent distribution, sample distribution, oscillation and mixing, incubation, centrifugation, washing and interpretation.
Through the fully automated inspection process, the labor intensity of the experimental personnel is greatly reduced, the detection efficiency is improved, and the possibility of manual errors is reduced.
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Figure CN110208561B_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of in vitro diagnostic medical devices, and particularly to a fully automatic platelet antibody detection device. Background Art
[0002] Principle of platelet antibody detection: Based on the solid-phase agglutination technology of antigen / antibody reaction, the reaction plate is pre-coated with anti-human platelet monoclonal antibody. After the platelet suspension is centrifuged and washed, a single layer of platelets can be formed at the bottom of the reaction plate. Serum and LISS solution are added to the corresponding micro-wells of the reaction plate for incubation. When the incubation is completed, if the serum or plasma contains platelet antibody, the antibody will bind to the single layer of platelets in the reaction well, and the unbound components are removed by washing. Then, anti-human IgG and human IgG-sensitized red blood cells (indicator red blood cells) are added. After centrifugation, the indicator red blood cells bind to the platelet antibody on the single layer of platelets through the bridging of anti-human IgG. Therefore, a positive reaction is that the indicator red blood cells are evenly spread on the bottom surface of the reaction well, while a negative reaction is that the indicator red blood cells aggregate at the center of the bottom of the reaction well under the action of centrifugal force.
[0003] Currently, platelet antibody detection (solid-phase agglutination method) is mainly manual operation, or semi-automatic operation with the cooperation of instruments such as centrifuges, plate washers, and incubators. It cannot automate the platelet antibody detection test. Relying on manual processing is time-consuming and error-prone, with low detection efficiency. Summary of the Invention
[0004] The purpose of the present invention is to overcome the shortcomings of the prior art and provide a safe and effective fully automatic platelet antibody detection device with reasonable layout, complete functions and easy implementation. Its function is to fully automate the processes of reagent dispensing, sample dispensing, oscillating and mixing, incubation, centrifugation, washing, and interpretation in platelet antibody detection, greatly reducing the labor intensity of experimental personnel and improving the detection efficiency.
[0005] The purpose of the present invention is achieved by the following technical solutions:
[0006] A fully automatic platelet antibody detection device, comprising a housing, a sample adding arm module, an outer ring turntable device, a centrifuge, an incubation module, a heat dissipation module, a sample carrier, a reagent carrier, a reading camera, a scanning head, a scanning head support plate and a driving device fixing seat. Among them, the driving device fixing seat is fixed on the bottom plate of the housing, and a driving device is installed on the driving device fixing seat. The outer ring turntable device is installed on the driving device, and the rotation of the outer ring turntable device is controlled by the driving device. The outer ring turntable device is of a hollow structure, and the centrifuge is installed inside the hollow structure of the outer ring turntable device. The incubation module and the heat dissipation module are arranged inside the centrifuge. The sample carrier and the reagent carrier are fixed at the circumferential position of the outer ring turntable device. The sample adding arm module is installed on the housing. The sample adding arm module includes a sample adding arm, a Y-direction support and a Y-direction transmission mechanism. The reading camera is installed on the sample adding arm. The scanning head support plate is fixed on the bottom plate of the housing, and the scanning head is installed on the scanning head support plate. The installation height of the scanning head matches the height at which the sample carrier is fixed on the outer ring turntable device. The scanning head is used to perform barcode scanning on the sample label and upload relevant information data to the system.
[0007] Further, the outer ring turntable device includes an outer ring turntable base and a carrier base. The outer ring turntable base and the carrier base are fixedly connected by a support rod. Three sample carriers and one reagent carrier are arranged along the circumferential position of the carrier base. The outer ring turntable device can perform circular rotation through the driving device connected to its bottom and rotate to the sample adding position according to system requirements.
[0008] Further, the sample carrier is a tube-type sample carrier, a bullet-type sample carrier or a mixed-type sample carrier. The tube-type sample carrier can be used to load tube samples, the bullet-type sample carrier can be used to load bullet-type samples, and the mixed-type sample carrier can be used to load tube samples and bullet-type samples at the same time. The mixed-type sample carrier includes a first frame body, a sample groove, and a bullet sample cartridge fixed above the sample groove for loading bullet samples. The bullet sample cartridge is used to fix the bullet sample on the sample carrier.
[0009] Further, the reagent carrier includes a second frame body, a first reagent groove, a second reagent groove, a third reagent groove, a fourth reagent groove, a fifth reagent groove, a sixth reagent groove, a seventh reagent groove and an eighth reagent groove. The first reagent groove, the second reagent groove, the third reagent groove, the fourth reagent groove, the fifth reagent groove and the sixth reagent groove are respectively used to load positive control reagent, negative control reagent, low ionic solution reagent, platelet suspension reagent, indicator red blood cell reagent and anti-human IgG reagent. The seventh reagent groove and the eighth reagent groove are used to load dilution washing solution. Among them, second mixing card seats and first mixing card seats are respectively arranged at the bottoms of the fourth reagent groove and the fifth reagent groove for oscillating and mixing the platelet suspension reagent and the indicator red blood cell reagent.
[0010] Further, the centrifuge includes a centrifuge housing, a centrifuge cover plate and a centrifuge rotor. A photographing and interpretation window is provided on one side of the centrifuge cover plate close to the sample adding arm module. The centrifuge rotor is connected to a centrifugal motor and can rotate at a high speed according to a control instruction. The centrifuge rotor is of a "×" - shaped frame structure. U - shaped card slots are respectively opened at the upper left corner, lower left corner, upper right corner and lower right corner of the centrifuge rotor. Centrifugal hanging baskets are arranged on the U - shaped card slots. An 8 - well microplate strip can be placed inside the centrifugal hanging basket. The bottom of the 8 - well microplate strip is coated with an antibody, which serves as a reaction carrier for the platelet antibody detection experiment. The shape and size of the photographing and interpretation window match those of the centrifugal hanging basket for placing the 8 - well microplate strip.
[0011] Further, a thermal printer is also provided on the outer housing.
[0012] Further, the incubation module includes a first incubation device and a second incubation device, which are correspondingly arranged below two opposite opening positions of the centrifuge rotor, mainly for heating the inner cavity of the centrifuge and incubating the reaction in the 8 - well microplate strip by means of air bath. The heat dissipation module includes a first heat dissipation device and a second heat dissipation device, which are correspondingly arranged below the other two opposite opening positions of the centrifuge rotor. The heat dissipation module starts to work after the incubation process is completed. The incubation process is completed in the inner cavity of the centrifuge. At this time, the temperature of the inner cavity is 37 °C. Since the entire experimental process of platelet antibody detection is completed in the inner cavity of the centrifuge, if all experimental steps are completed at 37 °C for a long time, it is equivalent to accelerating the experimental reaction, which will affect the interpretation of the final experimental results. Therefore, after the incubation process is over, it is necessary to quickly dissipate heat through the heat dissipation module to quickly empty the heat in the inner cavity of the centrifuge to avoid affecting the subsequent experimental process.
[0013] The working process of the automatic platelet antibody detection device described in the present invention:
[0014] Preparation before the experiment: Prepare a platelet suspension, prepare a dilution and washing solution, and place the relevant reagents on the reagent carrier rack correspondingly. Then place the 8 - well microplate strip coated with an antibody into the centrifugal hanging basket inside the centrifuge.
[0015] Turn on the power button to start the device power supply. Input relevant experimental parameters on the man - machine operation interface of the device and click to start the experiment. The driving device controls the outer - ring turntable device to rotate, drives the sample carrier rack fixed on the outer - ring turntable device to rotate, and then drives the sample to rotate. At the same time, the scanning head automatically scans the barcode of the sample label and uploads the relevant information data to the system.
[0016] The sample adding arm moves at the sample adding position in the Y direction through the Y-direction transmission mechanism. The outer ring turntable device moves the platelet suspension reagent to the sample adding position, and the sample adding arm aspirates the platelet suspension reagent and adds 50 μl to each reaction well of the 8-well microplate strip.
[0017] When the above sample adding process ends, the centrifuge starts to work and centrifuges at 50 g for 5 minutes.
[0018] When the above centrifugation process ends, the outer ring turntable device moves the dilution and washing solution to the sample adding position. The sample adding arm 201 aspirates the dilution and washing solution and drops the dilution and washing solution into each reaction well of the 8-well microplate strip for cleaning 3 times, with each drop amount being 200 μl.
[0019] When the above cleaning process ends, the outer ring turntable device moves the low ionic strength solution to the sample adding position. The sample adding arm aspirates the low ionic strength solution, adds 100 μl of the low ionic strength solution to each reaction well of the 8-well microplate strip, and sequentially adds 50 μl of the patient sample, positive control reagent, and negative control reagent to the corresponding wells of the 8-well microplate strip.
[0020] When the above sample adding process ends, the incubation module in the centrifuge starts to heat and maintains a constant temperature at 37 °C ± 0.5 °C for incubation for 30 min.
[0021] When the above incubation process ends, the outer ring turntable device moves the dilution and washing solution to the sample adding position. The sample adding arm 201 aspirates the dilution and washing solution and drops the dilution and washing solution into each reaction well of the 8-well microplate strip for cleaning 5 times, with each drop amount being 200 μl.
[0022] When the above cleaning process ends, the outer ring turntable device sequentially moves the anti-human IgG reagent and the indicator red blood cell reagent to the sample adding position. The sample adding arm sequentially adds 50 μl of the anti-human IgG reagent and 50 μl of the indicator red blood cell reagent to each reaction well of the 8-well microplate strip.
[0023] When the above sample adding process ends, the centrifuge starts to work. The centrifuge rotor 404 slightly shakes the 8-well microplate strip in a forward and reverse rotation manner to shake the reactants in the wells, and then centrifuges at 200 g for 5 minutes.
[0024] When the above centrifugation process ends, the reading camera installed on the sample adding arm moves to the photographing and reading window and faces the 8-well microplate strip for photographing, then performs image analysis to interpret the results, and finally the results are printed by a thermal printer.
[0025] Compared with the prior art, a full-automatic platelet antibody detection device provided by the present invention has the following beneficial effects:
[0026] A fully automatic platelet antibody detection device provided by the present invention can realize the full automation of processes such as reagent dispensing, sample dispensing, oscillating and mixing, incubation, centrifugation, washing, and interpretation in platelet antibody detection, greatly reducing the labor intensity of experimental personnel and improving the detection efficiency. BRIEF DESCRIPTION OF THE DRAWINGS
[0027] Figure 1 It is a schematic structural diagram of the fully automatic platelet antibody detection device of the present invention.
[0028] Figure 2 It is a top view of the fully automatic platelet antibody detection device of the present invention.
[0029] Figure 3 It is a schematic structural diagram of the outer ring turntable device of the present invention.
[0030] Figure 4 It is a schematic structural diagram of the centrifuge of the present invention.
[0031] Figure 5 It is a schematic internal structure diagram of the centrifuge of the present invention.
[0032] Figure 6 It is a schematic structural diagram of the hybrid sample carrier of the present invention.
[0033] Figure 7 It is a schematic structural diagram of the reagent carrier of the present invention.
[0034] Figure 8 It is a schematic bottom structure diagram of the reagent carrier of the present invention.
[0035] Among them, 1 - outer housing, 101 - outer housing bottom plate, 2 - sample adding arm module, 201 - sample adding arm, 202 - Y-direction support, 203 - Y-direction transmission mechanism, 3 - outer ring turntable device, 301 - outer ring turntable base, 302 - carrier base, 303 - support rod, 4 - centrifuge, 401 - centrifuge housing, 402 - centrifuge cover plate, 403 - photographing and interpretation window, 404 - centrifuge rotor, 405 - centrifuge basket, 5 - 8-well microplate strip, 6 - first incubation device, 7 - second incubation device, 8 - first heat dissipation device, 9 - second heat dissipation device, 10 - sample carrier, 1001 - first frame body, 1002 - sample slot, 1003 - bullet sample cartridge, 1004 - test tube sample, 1005 - bullet sample, 11 - reagent carrier, 1101 - second frame body, 1102 - first reagent slot, 1103 - second reagent slot, 1104 - third reagent slot, 1105 - fourth reagent slot, 1106 - fifth reagent slot, 1107 - sixth reagent slot, 1108 - seventh reagent slot, 1109 - eighth reagent slot, 1110 - first mixing clamp seat, 1111 - second mixing clamp seat, 12 - interpretation camera, 13 - scanning head, 14 - scanning head support plate, 15 - thermal printer, 16 - power button, 17 - drive device fixing seat, 18 - drive device. Detailed implementation manners
[0036] To describe in detail the technical features, achieved purposes and effects of the present invention, the following further description is made with reference to the accompanying drawings:
[0037] As Figures 1 - 8As shown in the figure, a fully automatic platelet antibody detection device includes an outer housing 1, a sample adding arm module 2, an outer ring turntable device 3, a centrifuge 4, an incubation module, a heat dissipation module, a sample carrier 10, a reagent carrier 11, an interpretation camera 12, a scanning head 13, a scanning head support plate 14, and a driving device fixing seat 17. Among them, the driving device fixing seat 17 is fixed on the bottom plate 101 of the outer housing, and a driving device 18 is installed on the driving device fixing seat 17. The outer ring turntable device 3 is installed on the driving device 18, and the rotation of the outer ring turntable device 3 is controlled by the driving device 18. The outer ring turntable device 3 is a hollow structure, and the centrifuge 4 is installed inside the hollow structure of the outer ring turntable device 3. The incubation module and the heat dissipation module are arranged inside the centrifuge 4. The sample carrier 10 and the reagent carrier 11 are fixed at the circumferential position of the outer ring turntable device 3. The sample adding arm module 2 is installed on the outer housing 1. The sample adding arm module 2 includes a sample adding arm 201, a Y-direction support 202, and a Y-direction transmission mechanism 203. The interpretation camera 12 is installed on the sample adding arm 201. The scanning head support plate 14 is fixed on the bottom plate 101 of the outer housing, and the scanning head 13 is installed on the scanning head support plate 14. The installation height of the scanning head 13 matches the height at which the sample carrier 10 is fixed on the outer ring turntable device 3. The scanning head 13 is used to perform barcode scanning on the sample label and upload relevant information data to the system.
[0038] As Figure 3 shown in the figure, the outer ring turntable device 3 includes an outer ring turntable base 301 and a carrier base 302. The outer ring turntable base 301 and the carrier base 302 are fixedly connected by a support rod 303. Three sample carriers 10 and one reagent carrier 11 are arranged along the circumferential position of the carrier base 302. The outer ring turntable device 3 can perform circular rotation through the driving device 18 connected to its bottom and rotate to the sample adding position according to system requirements.
[0039] As Figure 6 shown in the figure, the sample carrier 10 is a tube-type sample carrier, a bullet-type sample carrier, or a mixed-type sample carrier. The tube-type sample carrier can be used to load tube samples 1004, the bullet-type sample carrier can be used to load bullet-type samples 1005, and the mixed-type sample carrier can be used to load tube samples 1004 and bullet-type samples 1005 at the same time. The mixed-type sample carrier includes a first frame body 1001, a sample slot 1002, and a bullet-type sample cartridge 1003 fixed above the sample slot for loading bullet-type samples. The bullet-type sample cartridge 1003 is used to fix the bullet-type sample on the sample carrier 10.
[0040] As Figure 7As shown in the figure, the reagent carrier 11 includes a second carrier body 1101, a first reagent tank 1102, a second reagent tank 1103, a third reagent tank 1104, a fourth reagent tank 1105, a fifth reagent tank 1106, a sixth reagent tank 1107, a seventh reagent tank 1108 and an eighth reagent tank 1109. The first reagent tank 1102, the second reagent tank 1103, the third reagent tank 1104, the fourth reagent tank 1105, the fifth reagent tank 1106 and the sixth reagent tank 1107 are respectively used for loading positive control reagents, negative control reagents, low ionic solution reagents, platelet suspension reagents, indicator red blood cell reagents and anti-human IgG reagents. The seventh reagent tank 1108 and the eighth reagent tank 1109 are used for loading dilution washing solutions. Among them, second mixing holders 1111 and first mixing holders 1110 are respectively arranged at the bottoms of the fourth reagent tank 1105 and the fifth reagent tank 1106 for oscillating and mixing the platelet suspension reagents and the indicator red blood cell reagents.
[0041] As Figures 1 - 5 shown in the figure, the centrifuge 4 includes a centrifuge housing 401, a centrifuge cover plate 402 and a centrifuge rotor 404. A photographing and reading window 403 is arranged on one side of the centrifuge cover plate 402 close to the sample adding arm module 2. The centrifuge rotor 404 is connected to a centrifugal motor and can rotate at a high speed according to a control instruction. The centrifuge rotor 404 is of a "×" - shaped frame structure. U - shaped card slots are respectively opened at the upper left corner, the lower left corner, the upper right corner and the lower right corner of the centrifuge rotor 404. Centrifugal hanging baskets 405 are arranged on the U - shaped card slots. An 8 - well microplate strip 5 can be placed inside the centrifugal hanging basket 405. The bottom of the 8 - well microplate strip 5 is coated with an antibody, which serves as a reaction carrier for the platelet antibody detection experiment. The shape and size of the photographing and reading window 403 match the shape and size of the centrifugal hanging basket 405 for placing the 8 - well microplate strip 5.
[0042] As Figure 1 shown in the figure, a thermal printer 15 is further arranged on the outer housing 1.
[0043] As Figure 5As shown, the incubation module includes a first incubation device 6 and a second incubation device 7, which are correspondingly arranged below two opposite opening positions of the centrifuge rotor 404. They mainly heat the inner cavity of the centrifuge 4 and incubate the reaction in the 8-well microplate strip 5 through an air bath method. The heat dissipation module includes a first heat dissipation device 8 and a second heat dissipation device 9, which are correspondingly arranged below the other two opposite opening positions of the centrifuge rotor 404. The heat dissipation module starts to work after the incubation process is completed. The incubation process is completed in the inner cavity of the centrifuge 4. At this time, the temperature of the inner cavity is 37°C. Since the entire experimental process of platelet antibody detection is completed in the inner cavity of the centrifuge 4, if all experimental steps are completed at 37°C for a long time, it is equivalent to accelerating the experimental reaction, which will affect the interpretation of the final experimental results. Therefore, after the incubation process ends, it is necessary to quickly dissipate heat through the heat dissipation module to quickly empty the heat in the inner cavity of the centrifuge 4 to avoid affecting the subsequent experimental process.
[0044] The working process of the fully automatic platelet antibody detection device described in the present invention:
[0045] Preparation before the experiment: Prepare platelet suspension, prepare dilution and washing solution, and correspondingly place the relevant reagents on the reagent carrier 11. Then place the 8-well microplate strip 5 coated with antibodies into the centrifuge basket 405 inside the centrifuge 4.
[0046] Turn on the power button 16 to start the device power supply. Enter the relevant experimental parameters on the man-machine operation interface of the device and click to start the experiment. The driving device 18 controls the outer ring turntable device 3 to rotate, driving the sample carrier 10 fixed on the outer ring turntable device 3 to rotate, and then driving the sample to rotate. At the same time, the scanning head 13 automatically scans the barcode of the sample label and uploads the relevant information data to the system.
[0047] The sample adding arm 201 moves at the sample adding position in the Y direction through the Y-direction transmission mechanism 203. The outer ring turntable device 3 moves the platelet suspension reagent to the sample adding position. The sample adding arm 201 aspirates the platelet suspension reagent and adds 50 μl to each reaction well of the 8-well microplate strip 5.
[0048] When the above sample adding process ends, the centrifuge 4 starts to work and centrifuges at 50 g for 5 minutes.
[0049] When the above centrifugation process ends, the outer ring turntable device 3 moves the dilution and washing solution to the sample adding position. The sample adding arm 201 aspirates the dilution and washing solution and drops the dilution and washing solution into each reaction well of the 8-well microplate strip 5 for cleaning 3 times, with each drop amount being 200 μl.
[0050] When the above cleaning process ends, the outer ring turntable device 3 moves the low ionic strength solution to the sampling position. The sampling arm 201 aspirates the low ionic strength solution, adds 100 μl of the low ionic strength solution to each reaction well of the 8-well microplate strip 5, and sequentially adds 50 μl of the patient sample, positive control reagent, and negative control reagent to the corresponding wells of the 8-well microplate strip 5 respectively.
[0051] When the above sampling process ends, the incubation module in the centrifuge 4 starts to heat and maintain a constant temperature of 37°C ± 0.5°C for incubation for 30 min.
[0052] When the above incubation process ends, the outer ring turntable device 3 moves the dilution washing solution to the sampling position. The sampling arm 201 aspirates the dilution washing solution, and adds the dilution washing solution dropwise to each reaction well of the 8-well microplate strip 5 for 5 times, with each dropwise addition amount being 200 μl.
[0053] When the above cleaning process ends, the outer ring turntable device 3 sequentially moves the anti-human IgG reagent and the indicator red blood cell reagent to the sampling position. The sampling arm 201 sequentially adds 50 μl of the anti-human IgG reagent and 50 μl of the indicator red blood cell reagent to each reaction well of the 8-well microplate strip 5.
[0054] When the above sampling process ends, the centrifuge 4 starts to work. The centrifuge rotor 404 slightly shakes the 8-well microplate strip 5 by means of forward and reverse rotation to mix the reactants in the wells, and then centrifuges at 200 g for 5 minutes.
[0055] When the above centrifugation process ends, at this time, the reading camera 12 installed on the sampling arm moves to the photographing and reading window 403 and faces the 8-well microplate strip 5 to take a picture, then performs image analysis to judge the result, and finally the result is printed by the thermal printer 15.
[0056] Compared with the prior art, a kind of fully automatic platelet antibody detection device provided by the present invention has the beneficial effects that:
[0057] The fully automatic platelet antibody detection device provided by the present invention can realize the full automation of processes such as reagent distribution, sample distribution, oscillation and mixing, incubation, centrifugation, washing, and reading in platelet antibody detection, greatly reducing the labor intensity of experimental personnel and improving the detection efficiency.
[0058] What is described in the above embodiments and the specification is only the principle, main features, and advantages of the present invention. For those of ordinary skill in the art, various changes and improvements can be made without departing from the concept and scope of the present invention, and these changes and improvements all fall within the scope of the present invention claimed. Therefore, the protection scope of the patent of the present invention shall be subject to the appended claims.
Claims
1. An automatic platelet antibody detection device, characterized in that: It includes a housing (1), a sample addition arm module (2), an outer ring turntable device (3), a centrifuge (4), an incubation module, a heat dissipation module, a sample carrier (10), a reagent carrier (11), an interpretation camera (12), a scanning head (13), a scanning head support plate (14), and a drive device fixing seat (17). Among them, the drive device fixing seat (17) is fixed on the housing bottom plate (101), a drive device (18) is installed on the drive device fixing seat (17), the outer ring turntable device (3) is installed on the drive device (18), the outer ring turntable device (3) is of a hollow structure, the centrifuge (4) is installed inside the hollow structure of the outer ring turntable device (3), the incubation module and the heat dissipation module are arranged inside the centrifuge (4), the sample carrier (10) and the reagent carrier (11) are fixed at the circumferential position of the outer ring turntable device (3), the sample addition arm module (2) is installed on the housing (1), the sample addition arm module (2) includes a sample addition arm (201), a Y-direction support (202), and a Y-direction transmission mechanism (203), the interpretation camera (12) is installed on the sample addition arm (201), the scanning head support plate (14) is fixed on the housing bottom plate (101), the scanning head (13) is installed on the scanning head support plate (14), and the installation height of the scanning head (13) matches the height at which the sample carrier (10) is fixed on the outer ring turntable device (3); The centrifuge (4) includes a centrifuge housing (401), a centrifuge cover (402), and a centrifuge rotor (404). A photographing and interpretation window (403) is provided on one side of the centrifuge cover (402) close to the sample addition arm module (2); Both the incubation module and the heat dissipation module are arranged below the centrifuge rotor (404).
2. The fully automatic platelet antibody detection device according to claim 1, characterized in that: The outer ring turntable device (3) includes an outer ring turntable base (301) and a carrier base (302). The outer ring turntable base (301) and the carrier base (302) are fixedly connected by a support rod (303). Three sample carriers (10) and one reagent carrier (11) are arranged at the circumferential position of the carrier base (302).
3. The fully automatic platelet antibody detection device according to claim 2, wherein: The sample carrier (10) is a tube-type sample carrier, a bullet-type sample carrier, or a mixed-type sample carrier.
4. The fully automatic platelet antibody detection device according to claim 3, characterized in that: The mixed-type sample carrier includes a first frame body (1001), a sample groove (1002), and a bullet sample card sleeve (1003) fixed above the sample groove for loading bullet samples.
5. The full-automatic platelet antibody detection device according to claim 2, wherein: The reagent carrier (11) includes a second frame body (1101), a first reagent groove (1102), a second reagent groove (1103), a third reagent groove (1104), a fourth reagent groove (1105), a fifth reagent groove (1106), a sixth reagent groove (1107), a seventh reagent groove (1108), and an eighth reagent groove (1109). Among them, second mixing card seats (1111) and a first mixing card seat (1110) are respectively arranged at the bottoms of the fourth reagent groove (1105) and the fifth reagent groove (1106).
6. The fully automatic platelet antibody detection device according to claim 1, characterized in that: The centrifuge rotor (404) is connected to a centrifugal motor. The centrifuge rotor (404) has a "×"-shaped frame structure. U-shaped card slots are respectively formed at the upper left corner, lower left corner, upper right corner, and lower right corner of the centrifuge rotor (404). A centrifuge basket (405) is arranged on the U-shaped card slots. An 8-well microplate strip (5) can be placed inside the centrifuge basket (405). The shape and size of the photographing and interpretation window (403) match those of the centrifuge basket (405) for placing the 8-well microplate strip (5).
7. The fully automatic platelet antibody detection device according to claim 1, wherein: The incubation module includes a first incubation device (6) and a second incubation device (7), which are correspondingly arranged below two opposite opening positions of the centrifuge rotor (404). The heat dissipation module includes a first heat dissipation device (8) and a second heat dissipation device (9), which are correspondingly arranged below the other two opposite opening positions of the centrifuge rotor (404).
8. The fully automatic platelet antibody detection device according to claim 1, wherein: A thermal printer (15) is further arranged on the outer housing (1).
Citation Information
Patent Citations
Full-automatic blood bank system
CN203310842U
Full-automatic platelet antibody detection device
CN210243673U