Valve clip and valve clip system

Abstract

The present invention provides a valve clamp and a valve clamp system, the valve clamp system comprising a valve clamp and a pushing device. The valve clamp comprises a push rod, at least two clamps, at least one extension arm, and a driving assembly for driving the clamps to open and close and the extension arm to retract. Each clamp comprises a first clamp arm and a second clamp arm that can be relatively opened and closed, and at least one extension arm is retractably arranged on the surface of the first clamp arm. The present invention arranges a retractable extension arm on the surface of the first clamp arm of the valve clamp, and when the first clamp arm is opened relative to the second clamp arm of the valve clamp, the extension arm extends out of the first clamp arm, which is equivalent to increasing the length of the first clamp arm of the clamp. The longer first clamp arm can provide a better supporting effect on the valve leaflet when capturing the valve leaflet, preventing the valve leaflet from slipping off the surface of the first clamp arm, thereby being able to quickly capture the active valve leaflet, reduce the difficulty of surgery, and improve the efficiency of surgery.

Description

Technical Field

[0001] The present invention relates to the field of medical devices, and in particular to a valve clamp and a valve clamp system. Background Art

[0002] See also Figure 1 The mitral valve 1 is a one-way valve located between the left atrium 2 and the left ventricle 3 of the heart. A normal and healthy mitral valve 1 can control the blood flow from the left atrium 2 to the left ventricle 3, while preventing the blood from the left ventricle 3 to the left atrium 2. The mitral valve includes a pair of leaflets, called the anterior leaflet 1a and the posterior leaflet 1b. The anterior leaflet 1a and the posterior leaflet 1b are fixed to the inner wall of the left ventricle 3 by chordae tendineae 4. Under normal circumstances, when the left ventricle of the heart contracts, the edges of the anterior leaflet 1a and the posterior leaflet 1b are completely aligned to prevent blood from flowing from the left ventricle 3 to the left atrium 2. Please refer to Figure 2 When the mitral valve leaflets or their related structures undergo organic or functional changes (such as partial rupture of the chordae tendineae 4), the anterior leaflet 1a and the posterior leaflet 1b of the mitral valve are not properly aligned. When the left ventricle of the heart contracts, the mitral valve 1 cannot be completely closed, causing blood to flow back from the left ventricle 3 to the left atrium 2, thereby causing a series of pathophysiological changes, known as "mitral regurgitation."

[0003] There is a minimally invasive treatment surgery that delivers the leaflet clamp to the mitral valve through a push device, and then clamps the anterior and posterior leaflets of the mitral valve at the same time through the relative opening of the clamp, so that the anterior and posterior leaflets of the mitral valve are fixed to achieve the purpose of reducing mitral regurgitation. However, since the two leaflets of the mitral valve are always in a state of large-scale and strong opening and closing activities, it is difficult for the clamp to quickly and successfully capture the active leaflet tissue, so doctors often need to spend a long time to complete an operation. Summary of the invention

[0004] The object of the present invention is to provide a valve clamp and a valve clamp system to address the defects of the above-mentioned prior art, wherein the clamps of the valve clamp can easily and quickly capture active leaflet tissue, thereby reducing the difficulty of surgery and improving surgical efficiency.

[0005] The valve clamp comprises a push rod, at least two clamps, at least one extension arm and a driving assembly. One end of the clamp is connected to the push rod and opens and closes relative to the push rod; each clamp comprises a first clamp arm and a second clamp arm, the first clamp arm comprises a fixed end and a free end, the fixed end is rotatably connected to the push rod, the second clamp arm is arranged outside the push rod, and the first clamp arm opens and closes relative to the second clamp arm with the fixed position of the fixed end on the push rod as the rotation center; the extension arm is arranged on the surface of the first clamp arm of at least one clamp and extends along the fixed end of the first clamp arm toward the free end to extend or retract the first clamp arm; the driving assembly is connected to the first clamp arm and the extension arm, the driving assembly pushes the first clamp arm to open relative to the push rod and pushes the extension arm to extend from the first clamp arm; and the driving assembly pulls the first clamp arm to close relative to the push rod and pulls the extension arm to retract the first clamp arm.

[0006] Wherein, the extension arm comprises an extension arm body, and the extension arm body comprises one or more supporting rods arranged side by side.

[0007] Wherein, the extension arm further comprises a support body, the extension arm main body is made of a flexible material, the support body is made of a rigid material, and the support body is arranged inside and / or outside the extension arm main body.

[0008] In one embodiment, the extension arm body is a flexible tube or a flexible rod, and the support body is a rigid tube or a rigid rod, and the flexible tube or the flexible rod and the rigid tube or the rigid rod are coaxially sleeved together. In another embodiment, the extension arm body is made of a flexible material, and the support body is a heat shrink tube, and the heat shrink tube is sleeved outside the extension arm body and shrinks by heating to be fixed together with the extension arm body. In another embodiment, the extension arm body is wound by at least one flexible wire, and the support body is made of a thermoplastic elastomer material, and the thermoplastic elastomer material covers the outside of the extension arm body and penetrates into the inside of the extension arm body.

[0009] Wherein, the extension arm is at least partially made of a material that does not transmit X-rays.

[0010] Among them, an elastic member is provided at one end of the extension arm away from the fixed end of the first clamp arm, and the elastic member is compressed when the extension arm is retracted into the first clamp arm, and the elastic member is stretched when the extension arm is extended out of the first clamp arm, and the area of ​​the elastic member after stretching is greater than the area of ​​the elastic member when compressed.

[0011] In one embodiment, the elastic member includes a plurality of branches. When the elastic member is received in the first clamp arm, the plurality of branches are bundled together; when the elastic member is extended out of the first clamp arm, the plurality of branches are stretched and opened.

[0012] In another embodiment, the elastic member is a closed elastic ring. When the elastic ring is retracted into the first clamp arm, the elastic ring is squeezed and deformed; when the elastic ring extends out of the first clamp arm, the elastic ring stretches, and the area of ​​the elastic ring after stretching is larger than the area of ​​the elastic ring when squeezed.

[0013] Furthermore, at least one support strip is provided in the elastic ring, and an extending direction of the support strip is the same as a direction from the fixed end to the free end of the first clamp arm.

[0014] Wherein, the first clamp arm comprises a first surface facing the second clamp arm, and the surface where the elastic member is located is parallel to the first surface.

[0015] Wherein, the first surface is a curved surface, and the curvature direction of the curved surface is toward the second clamp arm.

[0016] The extension arm is limited on the first surface by a limiting member, and the limiting member is used to limit the extension direction of the extension arm to be along the direction from the fixed end to the free end of the first clamp arm.

[0017] Among them, the driving component includes a slider, which is arranged inside the push rod or sleeved outside the push rod and reciprocates along the axial direction of the push rod; one end of the extension arm is connected to the slider through an elastic rod, and the slider reciprocates along the axial direction of the push rod and drives the elastic rod to move, so as to drive the extension arm to extend and retract along the first clamp arm through the elastic rod.

[0018] Wherein, the elastic rod includes a first connecting section, a second connecting section, and a curved section located between the first connecting section and the second connecting section, the end of the first connecting section facing away from the curved section is fixedly connected to the slider, and the first connecting section is a line segment extending along the direction of the push rod; the end of the second connecting section facing away from the curved section is fixedly connected to the extension arm, the extension direction of the second connecting section is the same as the extension direction of the extension arm, the curved section is a curved structure with variable curvature, and the curved section keeps the second connecting section and the extension arm connected to the second connecting section against the surface of the first clamp arm.

[0019] In which, the driving assembly also includes at least one group of driving rods, each group of driving rods includes at least two driving rods, one end of the driving rod is connected to the slider, and the other end is connected to the first clamp arm, and is connected between the fixed end and the free end of the first clamp arm; the slider performs axial reciprocating motion along the push rod to drive the driving rod to rotate relative to the slider, and the driving rod rotates to drive the first clamp arm to open and close relative to the second clamp arm.

[0020] The second clamp arm comprises a fixed section at the distal end and a connecting section at the proximal end, and the connecting section of the second clamp arm is fixedly connected to the push rod, and the connecting section of the second clamp arm is made of elastic material.

[0021] Wherein, the second clamp arm comprises a third surface opposite to the first clamp arm, and a clamping reinforcement piece is disposed on the third surface.

[0022] The valve clamping system includes a pushing device and the above-mentioned valve clamping device, wherein the pushing device includes an operating handle and a pushing shaft with a certain axial length, wherein the proximal end of the pushing shaft is connected to the operating handle, and the distal end of the pushing shaft is detachably connected to the valve clamping device.

[0023] Among them, the pushing shaft includes a connecting shaft and a control shaft that are movably coaxially mounted together; the connecting shaft and the push rod are detachably connected, and the control shaft is connected to the driving assembly, and the control shaft drives the driving assembly to reciprocate along the axial direction of the push rod to drive the relative opening and closing between the first clamp arm, the push rod and the second clamp arm.

[0024] Wherein, the pushing device also includes an adjustment line connected to the second clamp arm.

[0025] The valve clamp and valve clamp system provided by the present invention are characterized by arranging a retractable extension arm on the surface of the first clamp arm, and making the first clamp arm open relative to the second clamp arm while the extension arm extends out of the first clamp arm, which is equivalent to increasing the length of the first clamp arm of the clamp when capturing the valve leaflet. The longer first clamp arm can provide better support for the valve leaflet when capturing the valve leaflet, preventing the valve leaflet from slipping off the surface of the first clamp arm, thereby being able to quickly capture the active valve leaflet tissue, reduce the difficulty of surgery, and improve surgical efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] In order to more clearly illustrate the structural features and effects of the present invention, it is described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0027] Figure 1 This is a schematic diagram of the mitral valve in its normal state;

[0028] Figure 2This is a schematic diagram of a mitral valve disease.

[0029] Figure 3 is a schematic structural diagram of a valve clipper in a folded state according to an embodiment of the present invention;

[0030] Figure 4 yes Figure 3 A schematic structural diagram of the valve clip when the first clamp arm is opened;

[0031] Figure 5 yes Figure 3 A cross-sectional schematic diagram of the valve clip when the first clamp arm is opened;

[0032] Figure 6 is a schematic diagram of the position of the valve clip of the present invention at the mitral valve;

[0033] Figure 7a is a schematic diagram of the mitral valve during heart contraction after the valve clipper of the present invention clamps the valve leaflet;

[0034] Figure 7b is a schematic diagram of the mitral valve during diastole after the valve clip of the present invention clamps the valve leaflet;

[0035] Figure 8 is a schematic structural diagram of a valve clipper according to another embodiment of the present invention when the first clamp arm is opened;

[0036] Fig. 9 is a schematic structural diagram of an extension arm of a valve clipper according to an embodiment of the present invention;

[0037] Fig.10 is a schematic structural diagram of an extension arm of a valve clipper according to another embodiment of the present invention;

[0038] Fig.11 4 is a schematic structural diagram of an extension arm of a valve clipper according to another embodiment of the present invention. DETAILED DESCRIPTION

[0039] The following will be combined with the accompanying drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. The accompanying drawings are only used for exemplary description and represent only schematic diagrams, and cannot be understood as limiting the present patent.

[0040] See also Figures 3 to 5 The present invention provides a valve clamp 100. The valve clamp 100 includes a push rod 40, at least two clamps 10, at least one extension arm 20 and a drive assembly 30. In this embodiment, there are two clamps 10, and the two clamps 10 are symmetrically arranged with the push rod 40 as the axis. For details, please refer to Figure 6The valve clip 100 is placed at the position A where the anterior leaflet and the posterior leaflet of the mitral valve cannot be normally coapted, so that one clamp 10 clamps the edge of the anterior leaflet 1a of the mitral valve, and the other clamp 10 clamps the edge of the posterior leaflet 1b of the mitral valve, and the two clamps 10 are folded together to fix the position A where the anterior leaflet 1a and the posterior leaflet 1b of the mitral valve cannot be normally coapted. Figure 7a When the heart contracts, the anterior leaflet 1a and the posterior leaflet 1b are closed together, and the position where the anterior leaflet 1a and the posterior leaflet 1b cannot be normally closed is clamped by the valve clamp 100, so that the position that cannot be normally closed or part of the position is closed together, so that the mitral valve can be completely closed or the opening area becomes smaller, thereby alleviating or treating "mitral regurgitation". Please refer to Figure 7b When the heart is in diastole, the anterior leaflet 1a and the posterior leaflet 1b are fixed together only at the position where the valve clip 100 is clamped, and the other positions of the anterior leaflet 1a and the posterior leaflet 1b are still in normal diastole, so that blood can enter the left ventricle from the left atrium, thereby ensuring the normal flow of blood. The valve clip 100 of other embodiments of the present invention can also be used to reduce or treat "tricuspid regurgitation", that is, the valve clip 100 has three clamps 10, and the three leaflets are fixed together by three clamps 10, thereby reducing or avoiding "tricuspid regurgitation". Its principle and structure are the same as the principle and structure of the valve clip 100 used to solve mitral regurgitation in the embodiment of the present invention, and will not be repeated here. It can be understood that the valve clip 100 of other embodiments of the present invention can also be used in other minimally invasive surgical operations that require clamping several sheet-like tissues together, and the number of clamps 10 varies according to actual use requirements.

[0041] Please review Figures 3 to 5The push rod 40 is detachably connected to the pushing device. The operator operates the pushing device in vitro, and after delivering the valve clamp 100 to the mitral valve, the pushing device is separated from the push rod 40, so that the valve clamp remains at the mitral valve. In one embodiment of the present invention, the push rod 40 is a rod-shaped body or a hollow tubular body with an inner cavity, and is made of a biocompatible material. The biocompatible material is selected from stainless steel, cobalt alloy or titanium alloy, preferably titanium alloy. Preferably, the push rod 40 is a round rod or a round tube, and the surface of the push rod 40 is smooth to prevent the push rod 40 from damaging the leaflets or hooking the chordae tendineae. In order to facilitate the pushing and fixing of the clamp 10 and the drive assembly 30, a base 41 is provided at the distal end of the push rod 40. In this embodiment, the base 41 includes two opposite first planes and a side surface connecting the two first planes. The side surface includes a curved surface 413 at the distal end and a second plane 412 at the proximal end and connected to the curved surface 413. The distal end of the push rod 40 is vertically fixed on the second plane 412, and the area of ​​the second plane 412 is larger than the cross-sectional area of ​​the push rod 40. The cross-sectional dimension of the base 41 parallel to the second plane 412 gradually decreases from the proximal end to the distal end, that is, the shape of the base 41 can be a hemisphere, a spherical cap, a bullet-shaped structure, etc., so that the valve clip 100 is easier to be pushed in the body. The "proximal end" described here refers to the direction close to the operator; the "distal end" refers to the direction away from the operator. The outer surface of the base 41 is smooth, so as to prevent the base 41 from damaging the valve leaflet or hooking the chordae tendineae. The push rod 40 is provided with a channel 42 along the axial direction. The channel 42 is a long strip. The length direction of the channel 42 is the same as the length direction of the push rod 40, and the longitudinal direction of the channel 42 is perpendicular to the two first planes of the base 41.

[0042] Each clamp 10 includes a first clamp arm 11 and a second clamp arm 12, and the first clamp arm 11 and the second clamp arm 12 are relatively opened and closed to clamp or loosen the valve leaflet between the first clamp arm 11 and the second clamp arm 12. Each first clamp arm 11 includes a fixed end 10a located at the distal end and a free end 10b located at the proximal end, and the fixed ends 10a of the two first clamp arms 11 are rotatably connected. Specifically, the fixed ends 10a of the two first clamp arms 11 of this embodiment are rotatably connected to the push rod 40 by means of pins or bolts, and specifically, are rotatably connected to the base 41 of the push rod 40, so that the two first clamp arms 11 are rotatably opened and closed relative to the push rod 10. Each second clamp arm 12 is arranged outside the push rod 40 and corresponds to a first clamp arm 11, so that the first clamp arm 11 is opened and closed relative to the second clamp arm 12 with the fixed position of the fixed end 10a on the push rod 40 as the rotation center. Therefore, when the valve clamp 100 is delivered to the mitral valve by the pushing device, the two first clamp arms 11 are tightened on the surface of the push rod 40, thereby reducing the volume of the valve clamp 100, so that it can be smoothly delivered to the mitral valve through the blood vessels; after the valve clamp 100 is delivered to the mitral valve, the two first clamp arms 11 are opened to form a certain angle with the push rod 40, so that each first clamp arm 11 can support a leaflet respectively, and then the first clamp arms 11 and the second clamp arms 12 of the two clamps 10 are closed, so as to clamp each leaflet respectively and fix the anterior leaflet 1a and the posterior leaflet 1b together.

[0043] In this embodiment, the first forceps arm 11 includes a connecting section 111 and a fixing section 112. The fixing section 112 is used to cooperate with the second forceps arm 12 to fix and clamp the leaflet between the first forceps arm 11 and the second forceps arm 12. One end of the connecting section 111 is connected to the fixing section 112, and the other end is connected to the base 41. The connecting section 111 includes two connecting rods arranged in parallel, and the connecting rods are arranged on two first planes opposite to the base 41. One end of each connecting rod is connected to the base 41, and the other end is fixed at intervals to the proximal end of the fixing section 112, so that the first forceps arm 11 is more firmly connected to the base 41. In other embodiments of the present invention, the connecting section 111 may also include only one connecting rod; or, the first forceps arm 11 does not include the connecting section 111, and the fixing section 112 is directly rotatably connected to the base 41.

[0044] In this embodiment, the fixing section 112 of the first clamp arm 11 includes a first surface 112a (i.e., the inner surface of the first clamp arm 11) facing the second clamp arm 12, and the first surface 112a is a curved surface, and the curvature direction of the curved surface faces the second clamp arm 12. By setting the first surface 112a as a curved surface, the contact area and clamping area between the first clamp arm 11 and the valve leaflet can be increased, thereby providing a stable clamping force and preventing the first clamp arm 11 from causing damage to the valve leaflet. When the curved first surface 112a is folded relative to the push rod 40, it can better contact the surface of the round rod-shaped push rod 40, so as to minimize the volume of the clamp 10 of the valve clip 100 when it is folded, so that the valve clip 100 is easier to be transported in the body. In order to ensure a stable clamping force and correspond to the size of the valve leaflet, the first clamp arm 11 has a certain size regulation. Specifically, the length of the first clamp arm 11 must be within a certain range. When the length of the first clamp arm 11 is too long, the first clamp arm 11 is easy to clamp too many anterior leaflets 1a and posterior leaflets 1b together. When the two clamps 10 are closed, the two leaflets are forcibly pulled toward each other and fixed together, which is not only easy to cause mitral valve dysfunction, but also when the heart beats and the leaflets move, due to the restriction of movement of too many leaflets, it may also cause leaflet tearing and other serious consequences; when the first clamp arm 11 is too short, the clamp 10 can only clamp a small part of the leaflets, making the leaflets easy to slip out, and the clamping and fixing effect is poor. In addition, since the leaflets are relatively soft, during the clamping process, the leaflets are easy to slip out of the first clamp arm 11, that is, the first clamp arm 11 is not easy to support the leaflets or cooperate with the second clamp arm 12 to clamp the leaflets, prolonging the operation time. In the present invention, the axial length of the first clamp arm 11 (i.e., the distance from the fixed end 10a to the free end 10b) should be greater than or equal to 4mm, preferably 6-10mm. In addition, the width of the first clamp arm 11 is also limited to a certain extent, so as to avoid the first clamp arm 11 from causing damage to the valve leaflets due to being too narrow, and to also avoid the influence of the clamp 10 on the movement of the valve leaflets when the width of the first clamp arm 11 is too wide. The width of the first clamp arm 11 (i.e., the length in the direction perpendicular to the axial direction of the first clamp arm 11) should be greater than or equal to 2 mm, preferably 4-6 mm. In addition, in order to ensure safety after implantation, the first clamp arm 11 should be made of a biocompatible material and have a certain degree of flexibility and rigidity, so as to avoid the first clamp arm 11 from causing damage to the valve leaflets, while being able to clamp and fix the valve leaflets. Specifically, the biocompatible material is selected from stainless steel, cobalt alloy or titanium alloy, and titanium alloy is used in this embodiment.

[0045] Furthermore, active drugs may be applied to the first surface 112a of the first clamp arm 11, or a plurality of openings may be provided to promote the endothelial cells of the valve tissue to crawl and grow on the inner surface of the first clamp arm 11. Furthermore, the first surface 112a may also be provided as a concave-convex surface with a concave-convex structure, thereby increasing the friction between the first clamp arm 11 and the valve leaflet and improving the fixing ability of the clamp 10 to the valve leaflet.

[0046] In this embodiment, the second clamp arm 12 is fixed to the outside of the push rod 10 and is disposed opposite to the first clamp arm 11 , that is, when the first clamp arm 11 is retracted onto the surface of the push rod 40 , the first clamp arm 11 can be aligned with the second clamp arm 12 .

[0047] Furthermore, the second clamp arm 12 includes a third surface 12a, and the third surface 12a is opposite to the first clamp arm 11. A clamping reinforcement 121 is provided on the third surface 12a to increase the friction between the second clamp arm 12 and the valve leaflet clamped between the first clamp arm 11 and the second clamp arm 12, thereby improving the clamping force of the clamp 10 on the valve leaflet. The clamping reinforcement 121 can be a convex ridge, a barb, a boss or other irregularly distributed protrusions convexly provided on the third surface 12a, or a rough surface at least partially covering the third surface 12a, thereby improving the clamping force of the clamp 10 on the valve leaflet. For example, a gasket made of a biocompatible material with a high friction coefficient is covered on the outer surface of the push rod 40, thereby increasing the surface roughness coefficient of the third surface 12a, thereby improving the clamping force of the clamp 10 on the valve leaflet. The clamping reinforcement 121 can also be a magnetic body arranged on the second clamp arm 12. In this case, a corresponding magnetic body is also arranged on the first clamp arm 11. Through the mutual magnetic attraction between the first clamp arm 11 and the second clamp arm 12, the purpose of enhancing the clamping force of the clamp 10 on the leaflet is achieved. In this embodiment, the clamping reinforcement 121 is two rows of convex teeth arranged at intervals. The two rows of convex teeth are relatively arranged on the two side edges of the second clamp arm 12. In addition, the angle between the axial direction of each convex tooth and the third surface 12a is less than or equal to 90°, so as to further enhance the clamping force of the clamp 10 on the leaflet. Furthermore, the end of the convex tooth away from the third surface 12a is a smooth arc surface, so as to avoid damaging the leaflet.

[0048] See also Figure 8 , a valve clip 200 according to another embodiment of the present invention is provided, the structure of the valve clip 200 is similar to Figure 5 and Figure 6The structure of the valve clipper 100 shown is basically the same, except that: the second clamp arm 12 is at least partially made of an elastic material such as nickel-titanium alloy. Specifically, the second clamp arm 12 includes a fixed section 12a located at the distal end and a connecting section 12b located at the proximal end, and the connecting section 12b of the second clamp arm 12 is fixedly connected to the push rod 40, and the connecting section 12b of the second clamp arm 12 is made of an elastic material. The fixed section 12a of the second clamp arm 12 can be made of a non-elastic material such as an aluminum alloy. In a natural state, the second clamp arm 12 and the push rod 40 are arranged at an angle. In addition, the angle between the second clamp arm 12 and the push rod 40 is greater than or equal to the angle between the first clamp arm 11 and the push rod 40 when the first clamp arm 11 is opened to the maximum state, thereby ensuring that there is a certain clamping force between the first clamp arm 11 and the second clamp arm 12 to clamp the valve leaflet located between the first clamp arm 11 and the second clamp arm 12. The fixed section 12a of the second clamp arm 12 is connected to the control member in the pushing device, and the fixed section 12a of the second clamp arm 12 is controlled by the control member to adjust the angle between the second clamp arm 12 and the push rod 40 and the opening and closing between the second clamp arm 12 and the first clamp arm 11. In this embodiment, the control member is an adjustment wire (not shown) made of metal or PTFE or other polymer materials, and the adjustment wire passes through the fixed section 12a of the second clamp arm 12 to bind the second clamp arm 12 to the surface of the push rod 40. When the positions of the first clamp arm 11 and the valve leaf are adjusted, the control of the fixed section 12a of the second clamp arm 12 by the adjustment wire is released, and the connecting section 12b of the second clamp arm 12 rebounds, driving the fixed section 12a of the second clamp arm 12 connected thereto to move in a direction away from the push rod 40 (i.e., a direction close to the first clamp arm 11), so that the second clamp arm 12 and the first clamp arm 11 clamp the valve leaf between them.

[0049] It is understandable that, in other embodiments, the connecting sections 12b of the two second clamp arms 12 can be connected together, or the two second clamp arms 12 can be integrally formed. Thus, the two second clamp arms 12 can be U-shaped structures, that is, each side of the U-shaped structure serves as a second clamp arm 12, which cooperates with a first clamp arm 11 to clamp a valve leaflet.

[0050] Please review Figure 3-Figure 5In the present invention, there is at least one extension arm 20, and one extension arm 20 is provided on the surface of the first clamp arm 11 of one clamp 10. In this embodiment, there are two extension arms 20, which are respectively provided on the surfaces of the first clamp arms 11 of two clamps 10. Specifically, the extension arm 20 can be provided on the first surface 112a of the first clamp arm 11 (i.e., the inner surface of the first clamp arm 11) or on the second surface opposite to the first surface 112a (i.e., the outer surface of the first clamp arm 11). The extension arm 20 can be extended and retracted along the fixed end 10a of the first clamp arm 11 toward the free end 10b, so as to extend or retract the first clamp arm 11. In this embodiment, the extension arm 20 extending from the first clamp arm 11 means that the end of the extension arm 20 extends from the free end 10b of the first clamp arm 11, that is, the end of the extension arm 20 is located on the side of the free end 10b away from the fixed end 10a; the retracting of the extension arm 20 into the first clamp arm 11 means that the end of the extension arm 20 is retracted to between the free end 10b and the fixed end 10a of the first clamp arm 11. When the extension arm 20 extends out of the first clamp arm 11, the extension arm 20 is equivalent to extending the length of the first clamp arm 11. When the first clamp arm 11 opens relative to the push rod 40 to capture the valve leaflet, the extended first clamp arm 11 can increase the width of the supported valve leaflet, so that the valve leaflet is not easy to slip off the first clamp arm 11, thereby making it easier for the clamp 10 to capture the valve leaflet and more convenient for the clamp 10 to clamp the valve leaflet. In addition, since the actual length of the first clamp arm 11 remains unchanged, the length of the clamp 10 clamping the valve leaflet will not actually change, avoiding the problem that may be caused by the excessive length of the clamp 10. Preferably, at least one extension arm 20 is provided on the inner surface and / or outer surface of the first clamp arm 11 of each clamp 10. So that the length of the first clamp arm 11 of each clamp 10 can be lengthened, so that the first clamp arm 11 of each clamp 10 can easily capture the valve leaflet. In this embodiment, the extension arm 20 is smooth as a whole, and one end extending out from the first clamp arm 11 is formed into a smooth round head by laser spot welding without defects such as burrs, edges, and corners, thereby avoiding damage to the valve leaflet.

[0051] In some embodiments of the present invention, the extension arm 20 includes an extension arm body. The extension arm body includes one or more support rods arranged side by side to directly support the leaflets through the support rods. The support rod can be a solid or hollow structure, or a single-layer or multi-layer composite structure. For example, the support rod can be a solid or hollow rod formed of one material, or a hollow tube with different inner diameters formed of multiple different materials. Alternatively, the support rod can also be wound by a single wire or multiple wires. The cross-section of the support rod can be a regular circular or elliptical, crescent-shaped, semicircular, polygonal, etc., preferably a circular shape, which is easy to process and can avoid damage to the leaflets by the support rod. Further, in this embodiment, the support rod is made of a flexible and / or elastic biocompatible material to adapt to the anatomical structure of the leaflets and the range of motion of the leaflets, and to avoid damage to the leaflets. For example, a metal material, a polymer material or a metal-polymer composite material can be selected. Specifically, the support rod is made of a metal-polymer composite material, and in this embodiment, nickel-titanium alloy and PTFE are used.

[0052] Furthermore, in other embodiments of the present invention, the extension arm 20 includes an extension arm body made of a flexible material, and also includes a support body, which is made of a rigid material, such as stainless steel or titanium alloy. The support body is arranged inside and / or outside the extension arm body to enhance the strength of the extension arm 20, so that the extension arm 20 has a certain flexibility to adapt to the anatomical structure of the leaflet and the range of motion of the leaflet, while having a certain rigidity to effectively support the leaflet. For example, in one embodiment, the extension arm body is a flexible tube made of a softer material, the support body is a rigid rod made of a material with a higher hardness, and the flexible tube is sleeved outside the rigid rod to form the extension arm 20. In this case, the support body is arranged outside the extension arm body. Alternatively, in another embodiment of the present invention, the extension arm body is a flexible rod, the support body is a rigid tube made of a material with a higher hardness, and the rigid tube is sleeved outside the flexible rod to form the extension arm 20. In this case, the support body is arranged inside the extension arm body. Alternatively, in another embodiment of the present invention, a heat shrink tube is used as a support body to wrap around the outer surface of the relatively soft extension arm body, and then the heat shrink tube is heated to shrink and then wrapped around the outer surface of the extension arm body to improve the support, that is, the extension arm body is a flexible rod, and the rigid support body is a heat shrink tube, and the heat shrink tube is sleeved outside the flexible rod and heated to shrink to be fixed with the flexible rod, and the support body is arranged outside the extension arm body. Alternatively, in another embodiment of the present invention, the extension arm body is wound by at least one flexible wire (such as stainless steel wire), and then a thermoplastic elastomer (such as Pebax) is wrapped around the outside of the extension arm body, and then the Pebax is heated to melt and cover the outside of the extension arm body. At the same time, part of the Pebax will penetrate into the interior of the extension arm body through the gaps between the flexible wires. Therefore, the support body is arranged inside and outside the extension arm body.

[0053] Further, the extension arm 20 is at least partially made of a non-X-ray transparent material. For example, the extension arm body and / or the support body are made of a non-X-ray transparent material, so that after the extension arm 20 extends from the clamp 10 and contacts the valve leaflet, the extension arm 20 can swing accordingly with the movement amplitude of the valve leaflet. At this time, the operator can quickly and accurately determine the position of the valve leaflet through X-rays. If the position is reasonable, the operator can drive the clamp 10 to clamp the valve leaflet, thereby shortening the operation time and improving the success rate of the operation. The non-X-ray transparent material is selected from stainless steel or nickel-titanium alloy.

[0054] For further information, see Fig. 9 , an elastic member 50 is provided at one end of the extension arm 20 away from the fixed end 10a of the first clamp arm 11. The elastic member 50 is compressed when the extension arm 20 is retracted into the first clamp arm 11. When the extension arm 20 extends out of the first clamp arm 11, the elastic member 50 is no longer subjected to external pressure and thus stretches and returns to a natural state. The area of ​​the elastic member 50 after stretching is greater than the area of ​​the elastic member 50 when compressed, so that there is a larger contact area between the elastic member 50 and the leaflet, so as to better fit the leaflet and improve the support of the extension arm 20 to the leaflet. Preferably, in the present invention, the surface where the elastic member 50 is located after stretching is parallel to the first surface 112a of the first clamp arm 11, so that there is a larger contact area between the elastic member 50 and the leaflet after stretching, thereby achieving a better support effect on the leaflet. Specifically, the first plane 112a and the surface where the elastic member 50 is located after stretching can both be planes or curved surfaces.

[0055] In one embodiment, the elastic member 50 includes a plurality of branches, and when the elastic member 50 is retracted into the first clamp arm 11, the plurality of branches are bundled together; when the elastic member 50 is extended out of the first clamp arm 11, the plurality of branches are stretched out, so that the area of ​​the elastic member 50 is increased relative to when the elastic member 50 is retracted into the first clamp arm 11. Specifically, the elastic member 50 of this embodiment has two branches, both extending from one end of the extension arm 20 away from the fixed end 10a of the first clamp arm 11. The angle α between the two branches ranges from 20° to 150°, preferably from 60° to 90°, so as to provide stable support for the leaflets supported on the extension arm 20.

[0056] See also Fig.10 In another embodiment of the present invention, the elastic member 50 is a closed elastic ring. The elastic ring can be a closed structure of a circle, a rhombus, an ellipse, a pear, a polygon or other irregular shapes. When the elastic ring is retracted into the first clamp arm 11, the elastic ring is squeezed and deformed; when the elastic ring is extended from the first clamp arm 11, the elastic ring stretches, and the area of ​​the elastic ring after stretching is larger than the area of ​​the elastic ring when squeezed, thereby enhancing the support of the extension arm 20 to the leaflet. For further information, please refer to Fig.11At least one support strip 51 is provided in the elastic ring to improve the stability of the elastic ring so that it will not deform too much when it is deployed to support the valve leaflets, and the elastic ring can maintain stable support for the valve leaflets. Furthermore, the extension direction of the support strip is the same as the direction from the fixed end 10a to the free end 10b of the first clamp arm 11, so that after the elastic ring is added with the support strip 51, it can still be easily retracted in the first clamp arm 11.

[0057] Please review Figures 3 to 5 Furthermore, in some embodiments of the present invention, the extension arm 20 can be limited to the first surface 112a of the first clamp arm 11 by a limiter 60. The limiter 60 is used to limit the extension direction of the extension arm 20 to the direction from the fixed end 10a of the first clamp arm 11 to the free end 10b, thereby limiting the radial displacement of the extension arm 20. The limiter 60 can be various limiter structures such as a limiter ring, a limiter groove or a limiter tube. Preferably, the limiter 60 is a limiter ring or a limiter tube, etc., and the extension arm 20 can also be fixed to the first surface 112a of the first clamp arm 11 through the limiter 60 to prevent the extension arm 20 from detaching from the first surface 112a during movement. Specifically, in this embodiment, the limiter 60 is a hollow columnar member with a certain length, and the extension arm 20 can be movably inserted into the columnar member.

[0058] In the present invention, the driving assembly 30 is used to control the relative opening and closing of the first clamp arm 11 and the second clamp arm 12 of the clamp 10 and the extension and retraction of the extension arm 20. The driving assembly 30 includes a slider 31 and at least one set of driving rods 32. The slider 31 is arranged inside the push rod 40 or sleeved outside the push rod 40 and reciprocates along the axial direction of the push rod 40. In this embodiment, the slider 31 is tubular, and the slider 31 is sleeved outside the push rod 40 and reciprocates along the axial direction of the push rod 40. In addition, two opposite guide holes 311 are provided on the tube wall of the slider 31. Each guide hole 311 is connected to the channel 42 of the push rod 40. Each driving rod 32 is used to connect the slider 31 and a first clamp arm 11, so that the first clamp arm 11 is driven to rotate through the slider 31. In this embodiment, there are two sets of driving rods 32, and the two sets of driving rods 32 are respectively arranged on the two first planes of the base 41. Each set of driving rods 32 includes two driving rods 32, one end of the driving rod 32 is rotationally connected to the slider 31, and the other end is rotationally connected to the first clamp arm 11. In addition, the connection position of the driving rod 32 on the first clamp arm 11 is located between the fixed end 10a and the free end 10b of the first clamp arm 11. The slider 31 reciprocates along the axial direction of the push rod 40 to drive the driving rod 32 to rotate relative to the slider 31, and the driving rod 32 rotates relative to the slider 31 to drive the first clamp arm 11 to rotate relative to the push rod 40, that is, to drive the first clamp arm 11 to open and close relative to the second clamp arm 12 outside the push rod 40. In this embodiment, one end of each set of driving rods 32 connected to the slider 31 is connected by a bolt or a pin to realize the rotation connection between the push rod 40 and the slider 31. In addition, the same end of the two sets of driving rods 32 located on the first plane on both sides of the base 41 is connected by the same bolt. Specifically, a bolt passes through the same end of a group of driving rods 32 and a guide hole 311 of the slider 31 in sequence, then passes through the channel 42 on the push rod 40 until it passes out from another guide hole 311 on the slider 31, and finally passes through one end of another group of driving rods 32 connected to the slider 31. When the slider 31 is moved along the push rod 40, the driving rod 32 pushes the first clamp arm 11 to open and close relative to the push rod 40. In addition, when the slider 31 moves axially along the push rod 40, the bolt connected to the slider 31 also moves in the channel 42 on the push rod 40 along the length direction of the channel 42 (i.e., the axial direction of the push rod 40). Since the length of the channel 42 has a certain range, the slider 31 also has a certain range of movement, thereby controlling the opening and closing of the first clamp arm 11 at a certain angle relative to the push rod 40.

[0059] Further, one end of the extension arm 20 is connected to the slider 31 through the elastic rod 25, and the slider 31 performs axial reciprocating motion along the push rod 40 and drives the elastic rod 25 to move, so as to drive the extension arm 20 to extend and retract along the first clamp arm 11 through the elastic rod 25. In this embodiment, the elastic rod 25 includes a first connecting section 251, a second connecting section 252, and a curved section 253 located between the first connecting section 251 and the second connecting section 252. One end of the first connecting section 251 away from the curved section 253 is fixedly connected to the slider 31, and the first connecting section 251 is a line segment extending along the direction of the push rod 40; one end of the second connecting section 252 away from the curved section 253 is fixedly connected to the extension arm 20, and the extension direction of the second connecting section 252 is the same as the extension direction of the extension arm 20. The curved section 253 is a curved structure with a variable curvature, which is usually made of elastic material and is used to keep the second connecting section 252 and the extension arm 20 connected to the second connecting section 252 against the surface of the first clamp arm 11. Furthermore, in this embodiment, a guide groove 411 is provided in the base 41, and the curved section 253 is inserted into the guide groove 411 and can move in the guide groove 411. The elastic rod 25 is a rod-shaped structure with elasticity, and in a natural state, the elastic rod 25 is a straight rod. When the elastic rod 25 is inserted into the guide groove 411, the straight rod-shaped elastic rod 25 is bent to form the curved section 253, and the bending stress of the curved section 253 is used to keep the second connecting section 252 and the extension arm 20 connected to the second connecting section 252 against the surface of the first clamp arm 11.

[0060] In the present invention, a retractable first extension arm 20 is provided on the surface of the first clamp arm 11 of the first clamp 10, and a retractable second extension arm 20 is provided on the surface of the first clamp arm 11 of the second clamp 10, so that when the first clamp arm 11 is opened relative to the second clamp arm 12, the first extension arm 20 and the second extension arm 20 are both extended, which is equivalent to increasing the length of the first clamp arm 11 of the first clamp 10 and the second clamp 10, so that the active leaflet tissue can be quickly captured, the difficulty of the operation can be reduced, and the efficiency of the operation can be improved.

[0061] The present invention also provides a valve clamping system, which includes a pushing device and the aforementioned valve clamp 100. The valve clamp 100 can be delivered to the mitral valve by the pushing device, and the valve clamp 100 can be adjusted to a suitable position of the mitral valve. The pushing device includes an operating handle for the operator to hold and a pushing shaft connected to the distal end of the operating handle and having a certain axial length. The proximal end of the pushing shaft is connected to the operating handle, and the distal end of the pushing shaft is detachably connected to the valve clamp. The operator pushes the valve clamp 100 to a predetermined position through the pushing shaft. Specifically, the pushing shaft includes a connecting shaft and a control shaft that are movably coaxially sheathed together, and the connecting shaft is detachably connected to the push rod 40, that is, the operating handle and the valve clamp 100 are connected through the connecting shaft. The control shaft is connected to the driving assembly, specifically, the control shaft is connected to the slider 31, so that the slider 31 of the driving assembly is driven by the control shaft to reciprocate along the axial direction of the push rod 40 to drive the relative opening and closing between the first clamp arm 11 and the push rod 40 and the second clamp arm 12, so that the clamps 10 of the valve clamp 100 clamp the multiple leaflets of the valve respectively, so as to achieve the purpose of reducing the gap between the leaflets and clamping the valve. The fitting relationship between the connecting shaft and the control shaft is determined by the fitting relationship between the push rod and the slider of the driving assembly. In this embodiment, the slider is sleeved outside the push rod, so the control shaft is sleeved outside the control shaft.

[0062] Furthermore, the pushing device of the present invention may also include other driving components. Figure 8 In the valve clip 200 shown, the pushing device further includes an adjustment wire connected to the second clamp arm 12, and the adjustment wire passes through the fixed section 12a of the second clamp arm 12 and is connected to the operating handle. The relative position between the second clamp arm 12, the first clamp arm 11 and the push rod 40 can be adjusted by controlling the adjustment wire through the operating handle. For example, when the valve clip is delivered in vivo, the adjustment wire is tightened to control the fixed section 12a of the second clamp 10, so that the second clamp arm 12 is retracted to the surface of the push rod 40; when the first clamp arm 11 is located at an appropriate position of the valve leaf, the restriction of the adjustment wire on the second clamp arm 12 is relaxed, so that the second clamp arm 12 stretches naturally, thereby cooperating with the first clamp arm 11 to clamp the valve leaf between the first clamp arm 11 and the second clamp arm 12.

[0063] The following takes the mitral valve repair process as an example to illustrate the operation method of the valve clipping system of the present invention, which mainly includes the following steps:

[0064] The first step is to push the valve clamp connected to it from the left atrium through the push shaft, through the mitral valve to the left ventricle. At this time, the first clamp arm 11 and the second clamp arm 12 of the valve clamp are both folded on the surface of the push rod 40.

[0065] Step 2: Adjust the relative position of the valve clamp and the mitral valve by the push shaft so that the two clamps 10 of the valve clamp are close to the anterior leaflet 1a and the posterior leaflet 1b of the mitral valve respectively.

[0066] Step 3: Move the slider 31 along the distal direction of the push rod 40 to drive the first clamp arm 11 to open relative to the push rod 40 , and at the same time make the extension arm 20 extend from the first clamp arm 11 .

[0067] Step 4: Adjust the direction of the valve clipper and observe the relative position of each first clamp arm 11 and the anterior leaflet 1a and the posterior leaflet 1b through X-ray or other equipment, so that the first clamp arm 11 is perpendicular to the apposition line of the mitral valve.

[0068] Step 5: Retract the slider 31 along the proximal end of the push rod 40, thereby driving the first clamp arm 11 to close relative to the second clamp arm 12 and the push rod 40, and the first clamp arm 11 is retracted to the surface of the push rod 40 again. At this time, the anterior leaflet 1a and the posterior leaflet 1b of the mitral valve are respectively clamped between a pair of first clamp arms 11 and the second clamp arm 12 located on the surface of the push rod 40, thereby grasping the two leaflets respectively.

[0069] Step 6: Release the connection between the slider 31 and the control shaft, and then release the connection between the push rod 40 and the push shaft, withdraw the push shaft from the patient's body, and leave the valve clamp in the patient's body to complete the edge-to-edge clamping of the mitral valve leaflets.

[0070] Furthermore, when the valve clip is as follows Figure 8 When the valve clamp 200 is shown, the fourth step and the fifth step also include the following steps: releasing the control of the control member on the second clamp arm 12, so that the second clamp arm 12 opens relative to the push rod 40 and cooperates with the first clamp arm 11 to clamp the valve leaflet between the first clamp arm 11 and the second clamp arm 12.

[0071] The valve clipping system of the present invention can be operated in vitro to clip the valve leaflets with the valve clipper, thereby alleviating or avoiding the problem of "mitral regurgitation". In addition, since the valve clipper can easily capture the valve leaflets, the difficulty of performing "mitral regurgitation" surgery with the valve clipping system is greatly reduced, and the operation time is reduced.

[0072] The above is a preferred embodiment of the present invention. It should be pointed out that a person skilled in the art can make several improvements and modifications without departing from the principle of the present invention. These improvements and modifications are also considered to be within the scope of protection of the present invention.

Claims

1. A valve clip, characterized in that: include: Putting; At least two clamps, one end of which is connected to the push rod and opens and closes relative to the push rod; each of the clamps includes a first clamp arm and a second clamp arm, the first clamp arm includes a fixed end and a free end, the fixed end is rotatably connected to the push rod, the second clamp arm is arranged outside the push rod, and the first clamp arm opens and closes relative to the second clamp arm with the fixed position of the fixed end on the push rod as the rotation center; At least one extension arm, the extension arm is provided on the surface of the first clamp arm of at least one of the clamps, and is telescopic along the fixed end of the first clamp arm toward the free end to extend or retract the first clamp arm; A driving assembly, wherein the driving assembly is connected to the first clamp arm and the extension arm, and the driving assembly pushes the first clamp arm to open relative to the push rod, and simultaneously pushes the extension arm to extend out of the first clamp arm; Furthermore, the driving assembly pulls the first clamp arm to close relative to the push rod, and pulls the extension arm to retract into the first clamp arm; In which, the driving assembly includes a slider, which is arranged inside the push rod or sleeved outside the push rod and reciprocates along the axial direction of the push rod; one end of the extension arm is connected to the slider through an elastic rod, and the slider reciprocates along the axial direction of the push rod and drives the elastic rod to move, so as to drive the extension arm to extend and retract along the first clamp arm through the elastic rod; the second clamp arm includes a third surface opposite to the first clamp arm, and a clamping reinforcement member is provided on the third surface.

2. The valve clip according to claim 1, characterized in that: The extension arm comprises an extension arm body, and the extension arm body comprises one or more supporting rods arranged side by side.

3. The valve clip according to claim 2, characterized in that: The extension arm further comprises a support body. The extension arm main body is made of a flexible material, and the support body is made of a rigid material. The support body is arranged inside and / or outside the extension arm main body.

4. The valve clip according to claim 3, characterized in that: The extension arm body is a flexible tube or a flexible rod, the support body is a rigid tube or a rigid rod, and the flexible tube or the flexible rod and the rigid tube or the rigid rod are coaxially sleeved together.

5. The valve clip according to claim 3, characterized in that: The extension arm body is made of a flexible material, the support body is a heat shrink tube, and the heat shrink tube is sleeved outside the extension arm body and is heated and shrunk to be fixed together with the extension arm body.

6. The valve clip according to claim 3, characterized in that: The extension arm body is formed by winding at least one flexible wire, and the support body is made of a thermoplastic elastomer material. The thermoplastic elastomer material covers the outside of the extension arm body and penetrates into the inside of the extension arm body.

7. The valve clip according to any one of claims 1 to 6, characterized in that: The extension arm is at least partially made of an X-ray opaque material.

8. The valve clip according to claim 1, characterized in that: An elastic member is provided at one end of the extension arm away from the fixed end of the first clamp arm. The elastic member is compressed when the extension arm is retracted into the first clamp arm, and is stretched when the extension arm is extended out of the first clamp arm. The area of ​​the elastic member after stretching is greater than the area of ​​the elastic member when compressed.

9. The valve clip according to claim 8, characterized in that: The elastic member comprises a plurality of branches. When the elastic member is received in the first clamp arm, the plurality of branches are bundled together; when the elastic member extends out of the first clamp arm, the plurality of branches are stretched and opened.

10. The valve clip according to claim 8, characterized in that: The elastic member is a closed elastic ring. When the elastic ring is received in the first clamp arm, the elastic ring is squeezed and deformed; when the elastic ring extends out of the first clamp arm, the elastic ring stretches, and the area of ​​the elastic ring after stretching is greater than the area of ​​the elastic ring when squeezed.

11. The valve clip according to claim 10, characterized in that: At least one support strip is arranged in the elastic ring, and the extension direction of the support strip is the same as the direction from the fixed end to the free end of the first clamp arm.

12. The valve clip according to any one of claims 8 to 11, characterized in that: The first clamp arm comprises a first surface facing the second clamp arm, and the surface where the elastic member is located is parallel to the first surface.

13. The valve clip according to claim 12, characterized in that: The first surface is a curved surface, and the curvature direction of the curved surface is toward the second clamp arm.

14. The valve clip according to claim 12, characterized in that: The extension arm is limited on the first surface by a limiting member, and the limiting member is used to limit the extension direction of the extension arm to be along the direction from the fixed end to the free end of the first clamp arm.

15. The valve clip according to claim 1, characterized in that: The elastic rod comprises a first connecting section, a second connecting section, and a curved section located between the first connecting section and the second connecting section, an end of the first connecting section away from the curved section is fixedly connected to the slider, and the first connecting section is a line segment extending along the direction of the push rod; One end of the second connecting section facing away from the bending section is fixedly connected to the extension arm, the extension direction of the second connecting section is the same as the extension direction of the extension arm, the bending section is a bending structure with variable curvature, and the bending section keeps the second connecting section and the extension arm connected to the second connecting section against the surface of the first clamp arm.

16. The valve clip according to claim 1, characterized in that: The driving assembly also includes at least one group of driving rods, each group of driving rods includes at least two driving rods, one end of the driving rod is connected to the slider, and the other end is connected to the first clamp arm, and is connected between the fixed end and the free end of the first clamp arm; the slider performs axial reciprocating motion along the push rod to drive the driving rod to rotate relative to the slider, and the driving rod rotates to drive the first clamp arm to open and close relative to the second clamp arm.

17. The valve clip according to claim 1, characterized in that: The second clamp arm comprises a fixed section at the distal end and a connecting section at the proximal end, and the connecting section of the second clamp arm is fixedly connected to the push rod, and the connecting section of the second clamp arm is made of elastic material.

18. A valve clamping system, characterized in that: It comprises a pushing device and the valve clamp according to any one of claims 1 to 17, wherein the pushing device comprises an operating handle and a pushing shaft with a certain axial length, the proximal end of the pushing shaft is connected to the operating handle, and the distal end of the pushing shaft is detachably connected to the valve clamp.

19. The valve clipping system according to claim 18, characterized in that: The pushing shaft includes a connecting shaft and a control shaft which are movably and coaxially mounted together; the connecting shaft is detachably connected to the push rod, and the control shaft is connected to the driving assembly, and the control shaft drives the driving assembly to reciprocate along the axial direction of the push rod to drive the relative opening and closing between the first clamp arm, the push rod and the second clamp arm.

20. The valve clipping system according to claim 18, wherein: The pushing device also includes an adjustment line connected to the second clamp arm.

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