Three-column inverse selection type molybdenum-99 / technetium-99m generator device and separation method

Abstract

The present invention relates to a three-column trans-selective molybdenum-99 / technetium-99m generator device and a separation method. The device includes a host computer (1), a fully automatic molybdenum-99 / technetium-99m separation device (3), a reaction module (16), a Mo-Tc feed liquid bottle (19), a product bottle (21), a dispensing solution bottle (9), a eluent No. 1 bottle (10), and a eluent No. 2 bottle (11); the fully automatic molybdenum-99 / technetium-99m separation device (3) includes a chassis, an injection pump module (14), a multi-channel switching valve (8), a pneumatic control valve (4), and a reaction module slide (17); the reaction module (16) includes a drain valve switch (15), a syringe (13), an adsorption column (5), an exchange column (6), and a protection column (7). The device has the characteristics of high automation degree, fast preparation speed, and high separation rate. The high degree of automation also reduces the irradiation effect of radioactive radiation on operators.

Description

Technical Field

[0001] The present invention belongs to the field of isotope radioactivity production, and particularly relates to an automated device for enriching 99 Tc nuclide from a low specific activity 99m Mo feed solution - a three-column trans-selective molybdenum-99 / technetium-99m generator system and method for preparing high-activity 99m sodium pertechnetate injection meeting the requirements of the pharmacopoeia. Background Art

[0002] Currently, 80 - 85% of the nuclear drugs used in medical imaging diagnosis in the world use 99m Tc. This radioactive isotope mainly comes from the 99 Mo- 99m Tc generator, where the parent nuclide 99 Mo undergoes β decay.

[0003] Currently, high specific activity 99 Mo (about 50000 Ci / g Mo) is obtained by uranium fission production. The world's high specific activity 99 Mo is mainly provided by reactors in countries such as the Netherlands, Belgium, France, South Africa, Australia, and Russia. In the event of reactor shutdown for maintenance or decommissioning in the main production countries, the supply of fission 99 Mo may face shortages.

[0004] Non-fission methods for producing 99 Mo usually use 98 Mo and 100 Mo as raw materials and are prepared by irradiating with a reactor or using an accelerator. In the low specific activity 99 Mo prepared by non-fission methods, non-radioactive Mo overwhelmingly dominates. Therefore, in the existing fission 99 Mo- 99m Tc generator structure, a large amount of alumina needs to be added to load enough 99 Mo to decay enough 99m Tc. Since 99m Tc will have a certain proportion of residue when eluted with sodium chloride injection, to obtain the 99 Mo- 99m Tc generator's 99m Tc elution activity, a large amount of sodium chloride injection is required, resulting in a low 99m Tc concentration in the eluate, which cannot meet the requirements of the pharmacopoeia. The three-column MSIG separation and purification technology solves the problem of extracting technetium ([[]] 99 Tc) nuclide from a low specific activity molybdenum ( 99m Mo) feed solution. The three-column MSIG separation and purification technology and the traditional fission 999 Mo-99m Aluminum column adsorption of Tc generator 99 Mo and elution 99m Different from Tc, the key is to use a solid-phase material to adsorb trace amounts of 99 from a Mo feed solution containing a large amount of 99m Tc, while not adsorbing or adsorbing very little 99 Mo, so as to achieve the separation of molybdenum and technetium. At present, there is no fully automatic molybdenum-99 / technetium-99m preparation device developed for the three-column separation and purification technology process. SUMMARY OF THE INVENTION

[0005] Aiming at the problem of extracting 99 Tc radionuclide from a low-specific-activity 99m Mo feed solution in the background art, the purpose of the present invention is to provide a new type of fully automatic three-column trans-selective molybdenum-99 / technetium-99m generator device. This device has the characteristics of high automation degree, fast preparation speed, high separation rate, etc. High automation also reduces the irradiation effect of radioactive radiation on operators.

[0006] In order to achieve the above object, the present invention provides the following technical solutions:

[0007] A three-column trans-selective molybdenum-99 / technetium-99m generator device, the device includes a host computer (1), a fully automatic molybdenum-99 / technetium-99m separation device (3), a reaction module (16), a Mo-Tc feed solution bottle (19), a product bottle (21), a liquid preparation solution bottle (9), a eluent No. 1 bottle (10), and a eluent No. 2 bottle (11). The fully automatic molybdenum-99 / technetium-99m separation device (3) includes a chassis, an injection pump module (14), a multi-channel switching valve (8), a pneumatic control valve (4), and a reaction module slide table (17); the reaction module (16) includes a drain valve switch (15), a syringe (13), an adsorption column (5), an exchange column (6), and a protection column (7);

[0008] The host computer is connected to the full-automatic molybdenum-99 / technetium-99m separation device (3) through a cable; the reaction module (16) is plugged into the valve slot of the reaction module slide table (17); the reaction module slide table (17) is arranged at the bottom of the front panel of the chassis; the pneumatic control valve (4) is arranged above the reaction module slide table (17), and its position corresponds to the valve switch of the reaction module (16); the valve switch (15) is sleeved in the valve sleeve of the pneumatic control valve (4); the multi-channel switching valve (8) is arranged above the front panel of the chassis. The common port of the multi-channel switching valve (8) is connected to the liquid inlet of the reaction module (16) through a hose, and the other ports of the multi-channel switching valve (8) are respectively connected to the liquid preparation solution bottle (9), the eluent No. 1 bottle (10), and the eluent No. 2 bottle (11); the syringe (13) is matched with the injection pump module (14); the injection pump module (14) is arranged above the pneumatic control valve (4), right in the position facing the syringe (13); the Mo-Tc feed liquid bottle (19) and the product bottle (21) are respectively connected to the valve interface of the reaction module (16) through hoses;

[0009] The adsorption column (5), the exchange column (6) and the guard column (7) are respectively connected to the reaction module (16).

[0010] As a preferred solution, the processing and control component of the host computer (1) is a touch all-in-one computer; the touch all-in-one computer sets the parameters of each working station through the touch screen (2) and monitors the operation of the separation system.

[0011] As a preferred solution, the pneumatic control valve (4) includes 12 groups of pneumatic rotary swing cylinders (4-3), valve sleeves (4-4), pneumatic control valve islands (4-2) and I / O controllers (4-1);

[0012] The 12 groups of pneumatic rotary swing cylinders (4-3) are arranged above the reaction module slide table (17), and their positions correspond to the valve switch (15); the 12 groups of pneumatic rotary swing cylinders (4-3) are assembled with the valve sleeve (4-4), and the valve sleeve (4-4) can be embedded into the corresponding valve switch (15); the pneumatic control valve island (4-2) is connected to the 12 groups of pneumatic rotary swing cylinders (4-3) through air pipes, and the air drive interface of the pneumatic control valve island (4-2) is connected to the air circuit interface on the rear panel of the chassis; the I / O controller (4-1) is connected to the electric interface of the pneumatic control valve island (4-2), and the I / O controller (4-1) is connected to the data cable on the rear panel of the chassis.

[0013] As a preferred solution, the device further includes a waste liquid collection bottle (20), and the waste liquid collection bottle (20) is respectively connected to the valve interface of the reaction module (16) through hoses.

[0014] As a preferred solution, the device further includes a vent port (12), and the vent port (12) is arranged at one port of the multi-channel switching valve (8).

[0015] As a preferred solution, the adsorption column (5) is an adsorption column for solid-phase extraction; the exchange column (6) is a strongly acidic ion exchange column; the guard column (7) is an acidic alumina guard column.

[0016] Among them, the solid-phase extraction packing is usually a chromatographic adsorbent, which can be divided into three categories: the first category is based on silica gel (such as C18, C8, etc.); the second category is based on polymers, such as polystyrene-divinylbenzene, etc.; the third category is mainly inorganic materials, such as Florisil, alumina, graphitized carbon, etc. The present invention uses an activated carbon material as the solid-phase extraction packing.

[0017] The second object of the present invention is to provide a method for enriching 99 Tc nuclide from a low specific activity 99m Mo feed solution. The method uses the three-column reverse selection type molybdenum-99 / technetium-99m generator device as described above, and the method includes the following steps:

[0018] (1) Device initialization: The upper computer runs a program, resets the injection pump module, multi-channel switching valve, and pneumatic control valve through cable communication. The program controls the operation of the pneumatic control valve and multi-channel switching valve. The liquid preparation solution bottle is connected to the syringe on the injection pump module through the multi-channel switching valve and a hose. The program controls the injection pump module to drive the syringe to operate. After extracting a set volume of the liquid preparation solution, the syringe is pushed to move, and the pipelines of the entire device are cleaned.

[0019] (2) 99m Tc adsorption: The upper computer controls the pneumatic control valve through running a program and cable communication, drives the drain valve switch of the reaction module, and connects the output port of the Mo-Tc feed solution bottle. The program controls the syringe module to drive the syringe to inhale a set amount of Mo-Tc feed solution. Through the control of the drain valve switch of the reaction module, the syringe module drives the syringe to push the Mo-Tc feed solution into the adsorption column, so that 99m Tc is adsorbed in the material of the adsorption column, and then the Mo-Tc feed solution flows back to the Mo-Tc feed solution bottle through the input port of the Mo-Tc feed solution bottle.

[0020] (3) 99 Mo washing: The upper computer runs a program, controls the multi-channel switching valve through cable communication. The multi-channel switching valve is switched to the liquid preparation solution bottle. The program controls the syringe module to drive the syringe to inhale a set amount of the liquid preparation solution; then a set amount of the liquid preparation solution is pushed out through the adsorption column, and the liquid preparation solution flushes the residual Mo feed solution on the material in the adsorption column.

[0021] (4) 99m Tc elution, neutralization, and adsorption by the guard column: The host computer runs a program to control the multi-channel switching valve through cable communication. The multi-channel switching valve switches to the 1st eluent bottle. The program controls the syringe module to drive the syringe to aspirate a set amount of the 1st eluent. The program controls the pneumatic control valve to drive the exhaust valve switch of the reaction module, connecting the adsorption column, exchange column, and guard column. The program controls the syringe module to drive the syringe to eject a set amount of the 1st eluent, causing the 1st eluent to sequentially pass through the adsorption column, exchange column, and guard column; causing 99m the Tc nuclide to be eluted from the adsorption column, neutralized through the exchange column reaction, and adsorbed and retained by the acidic guard column;

[0022] (5) Eluting the guard column to obtain sodium pertechnetate 99m Tc] injection: The host computer runs a program to control the multi-channel switching valve through cable communication. The multi-channel switching valve switches to the 2nd eluent bottle. The program controls the syringe module to drive the syringe to aspirate a set amount of the 2nd eluent. The program controls the pneumatic control valve to drive the exhaust valve switch of the reaction module, connecting the guard column and the product bottle. The program controls the syringe module to drive the syringe to eject a set amount of the 2nd eluent, causing the 2nd eluent to sequentially pass through the guard column to elute the guard column to obtain sodium pertechnetate 99m Tc] injection, and the solution is collected by the product bottle;

[0023] (6) Cleaning device: The host computer runs a program to control the multi-channel switching valve through cable communication. The multi-channel switching valve switches to the 1st eluent bottle. The program controls the syringe module to drive the syringe to aspirate a set amount of the 1st eluent. The program controls the pneumatic control valve to drive the exhaust valve switch of the reaction module, connecting the guard column. The program controls the syringe module to drive the syringe to eject a set amount of the 1st eluent, causing the 1st eluent to sequentially pass through the guard column;

[0024] The adsorption column is a solid-phase extraction adsorption column, and the solid-phase extraction packing is an activated carbon material; the exchange column is a strong acidic ion exchange column; the guard column is an acidic alumina guard column;

[0025] The dispensing solution is a NaOH solution with a concentration of 0.01 - 5 mol / L; the 1st eluent is injection water; the 2nd eluent is NaCl injection.

[0026] As a preferred solution, the following steps are further included between step (3) and step (4):

[0027] Pump head washing: The host computer runs the program and controls the multi-channel switching valve through cable communication. The multi-channel switching valve is switched to the eluent No. 1 bottle 10. The program controls the syringe module to drive the syringe to aspirate a set amount of eluent No. 1. The program controls the pneumatic control valve to drive the drain valve switch of the reaction module to connect the waste liquid bottle pipeline. Push the syringe to rinse the syringe and the pipeline of the reaction module with eluent No. 1 to reduce 99 the residual influence of Mo feed liquid.

[0028] As a preferred solution, the method further includes the following steps:

[0029] When waste liquid is generated, the program controls the pneumatic control valve to drive the drain valve switch of the reaction module to connect the waste liquid bottle pipeline, so that the waste liquid flows into the waste liquid bottle.

[0030] As a preferred solution, steps (1) and (6) respectively further include the following steps:

[0031] The program controls the multi-channel switching valve to connect to the vent port, and uses gas to drive the residual liquid to flow into the waste liquid bottle.

[0032] The beneficial effects of the present invention are as follows:

[0033] The three-column trans-selective molybdenum-99 / technetium-99m generator device provided by the present invention has a high degree of automation. Only by programming the program flow block according to the determined process flow, the three-column trans-selective molybdenum-99 / technetium-99m generator device can complete actions according to the corresponding process program. The preparation speed has been greatly improved compared with the manual separation and purification operation of chemical experimental containers, and the liquid volume control accuracy is much higher than that of a peristaltic pump for controlling the liquid volume. The three-column trans-selective molybdenum-99 / technetium-99m generator device reduces human intervention and also reduces the irradiation effect of radioactive radiation on operators. Description of the Drawings

[0034] Figure 1 is a schematic structural diagram of a three-column trans-selective molybdenum-99 / technetium-99m generator device;

[0035] Figure 2 is a schematic connection diagram of a fully automatic molybdenum-99 / technetium-99m separation device;

[0036] In the figure, 1 - host computer; 2 - touch screen; 3 - fully automatic molybdenum-99 / technetium-99m separation device; 4 - pneumatic control valve; 5 - adsorption column; 6 - exchange column; 7 - protection column; 8 - multi-channel switching valve; 9 - liquid preparation solution bottle; 10 - eluent bottle No. 1; 11 - eluent bottle No. 2; 12 - ventilation port; 13 - syringe; 14 - injection pump module; 15 - drain valve switch; 16 - reaction module; 17 - reaction module slide; 18 - locking switch; 19 - Mo-Tc feed liquid bottle; 20 - waste liquid bottle; 21 - product bottle; 22 - cable; 23 - hose; 24 - data interface; 4-1 - I / O controller; 4-2 - pneumatic control valve island; 4-3 - pneumatic rotary swing cylinder; 4-4 - valve sleeve. Detailed implementation mode

[0037] The following combines the attached drawings and the implementation mode to elaborate in detail on the specific implementation plan of the present invention.

[0038] The present invention provides a three-column trans-selective molybdenum-99 / technetium-99m generator device, the structure of which is as Figure 1 shown, including a host computer 1, a fully automatic molybdenum-99 / technetium-99m separation device 3, a reaction module 16, a Mo-Tc feed liquid bottle 19, a product bottle 21, a waste liquid bottle 20, etc.

[0039] The host computer 1 adopts an embedded operating system, and a touch all-in-one computer is used as the host computer processing and control component. The main controller of the touch all-in-one computer is connected to the fully automatic molybdenum-99 / technetium-99m separation device 3 through a cable 22, mainly controlling the operation of the multi-channel switching valve 8, the pneumatic control valve 4, and the injection pump module 14 in the molybdenum-99 / technetium-99m separation device 3. The touch all-in-one computer sets the parameters of each station through the touch screen 2 and monitors the operation of the separation system.

[0040] The reaction module 16 is a module combination assembled according to the determined low-activity molybdenum-99 / technetium-99m separation and purification process flow. The reaction module 16 includes a drain valve switch 15, a syringe 13, an adsorption column 5, an exchange column 6, a protection column 7, a hose 23, etc. The reaction module 16 is a replaceable structure, plugged into the drain valve slot of the reaction module slide 17 of the fully automatic molybdenum-99 / technetium-99m separation device. The drain valve switch 15 of the reaction module 16 is sleeved in the pneumatic control valve 4 of the fully automatic molybdenum-99 / technetium-99m device 3. By software control, the pneumatic control valve 4 is driven to act, realizing the cut-off of the drain valve switch 15 of the reaction module 16, and completing the separation and purification process of the set process flow by flowing through a multiphase formulated liquid.

[0041] The full-automatic molybdenum-99 / technetium-99m separation device 3 consists of a chassis, an injection pump module 14, a multi-channel switching valve 8, a pneumatic control valve 4, a reaction module slide 17, etc. Inside the chassis, there are a pneumatic control valve island 4-2 that drives the pneumatic rotary swing cylinder 4-3 and an I / O controller 4-1. At the bottom of the front panel of the chassis, the reaction module slide 17 is installed. There is a drain valve slot on the reaction module slide 17, into which the reaction module 16 can be inserted. The reaction module slide 17 can slide back and forth, and the reaction module 16 can be docked with the pneumatic control valve 4 along with the forward movement of the reaction module slide 17. The pneumatic control valve 4 consists of 12 groups of pneumatic rotary swing cylinders 4-3, valve sleeves 4-4, a pneumatic control valve island 4-2, and an I / O controller 4-1 (as Figure 2 shown). The 12 groups of pneumatic rotary swing cylinders 4-3 are installed on the upper side of the reaction module slide 17 on the front panel of the chassis. The positions of the 12 groups of pneumatic rotary swing cylinders 4-3 correspond to the positions of the drain valve switches 15 of the reaction module 16. The 12 groups of pneumatic rotary swing cylinders 4-3 are assembled with the valve sleeves 4-4, and the valve sleeves 4-4 can be embedded into the drain valve switches 15 of the corresponding reaction module 16 to achieve the corresponding actions of the drain valve switches 15. The 12 groups of pneumatic rotary swing cylinders 4-3 are connected to the pneumatic control valve island 4-2 through air pipes. The air drive interface of the pneumatic control valve island 4-2 is connected to the air path interface on the rear panel of the chassis, and the electric interface of the pneumatic control valve island 4-2 is connected to the I / O controller 4-1. The I / O controller 4-1 is connected to the data cable 22 on the rear panel of the chassis, and the I / O controller 4-1 is controlled through the program software of the upper computer 1. After the reaction module slide 17 is advanced, the locking switch 18 of the reaction module slide 17 is rotated, and the syringe 13 on the reaction module 16 is cooperated with the injection pump module 14. The multi-channel switching valve 8 is installed at the upper position of the front panel of the chassis. The common port of the multi-channel switching valve 8 is connected to the liquid inlet of the reaction module 16 through a hose 23, and the other ports of the multi-channel switching valve 8 are respectively connected to the liquid preparation solution bottle 9, the eluent No. 1 bottle 10, the eluent No. 2 bottle 11, and the ventilation port 12.

[0042] Combined with the developed three-column MSIG separation and purification process and the characteristics of the operating environment, the full-automatic elution process is adopted for operation description:

[0043] 1. Device initialization

[0044] The host computer 1 runs a program and communicates through cable 22 to reset the injection pump module 14, multi-channel switching valve 8, and pneumatic control valve 4 of the fully automatic molybdenum-99 / technetium-99m separation device 3. The program controls the operation of the pneumatic control valve 4 and the multi-channel switching valve 8. The liquid dispensing solution bottle 9 can be connected to the syringe 13 on the injection pump module 14 through the multi-channel switching valve 8 and the hose 23. The program controls the injection pump module 14 to drive the syringe 13 to operate. After extracting a set volume of the liquid dispensing solution (NaOH solution with a concentration of 0.01 - 5 mol / L), the program drives the syringe 13 to move and clean the pipelines of the entire device, and the liquid flows into the waste liquid bottle 20. The program controls the multi-channel switching valve 8 to connect to the ventilation port 12 and uses gas to drive the residual liquid in the hose 23 to be discharged.

[0045] 2. 99m Tc adsorption process

[0046] The host computer 1 runs a program and communicates through cable 22 to control the pneumatic control valve 4 of the fully automatic molybdenum-99 / technetium-99m separation device 3, drive the drain valve switch 15 of the reaction module 16, and connect to the output port of the Mo-Tc feed liquid bottle 19. The program controls the syringe module 14 to drive the syringe 13 to inhale a set amount of Mo-Tc feed liquid. Through the control of the drain valve switch 15 of the reaction module 16, the syringe module 14 drives the syringe 13 to push the Mo-Tc feed liquid into the adsorption column (solid phase extraction adsorption column, the solid phase extraction packing is made of activated carbon material) 5, so that 99m Tc is adsorbed in the material of the adsorption column 5, and then the Mo-Tc feed liquid flows back to the Mo-Tc feed liquid bottle 19 through the input port of the Mo-Tc feed liquid bottle 19.

[0047] 3. 99 Mo washing process

[0048] The host computer 1 runs a program and communicates through cable 22 to control the multi-channel switching valve 8 of the fully automatic molybdenum-99 / technetium-99m separation device 3. The multi-channel switching valve 8 is switched to the liquid dispensing solution bottle 9. The program controls the syringe module 14 to drive the syringe 13 to inhale a set amount of the liquid dispensing solution (NaOH solution with a concentration of 0.01 - 5 mol / L). The program controls the pneumatic control valve 4 to drive the drain valve switch 15 of the reaction module 16 to connect the adsorption column 5 to the waste liquid bottle 20 pipeline. The program controls the syringe module 14 to drive the syringe 13 to push out a set amount of the liquid dispensing solution through the adsorption column 5, and the liquid dispensing solution flushes the residual Mo feed liquid on the material in the adsorption column 5, and the waste liquid flows into the waste liquid bottle 20 through the pipeline of the reaction module 16.

[0049] 4. Pump head washing process

[0050] The host computer 1 runs a program and controls the multi-channel switching valve 8 of the fully automatic molybdenum-99 / technetium-99m separation device 3 through communication via cable 22. The multi-channel switching valve 8 is switched to the eluent No. 1 bottle 10. The program controls the syringe module 14 to drive the syringe 13 to aspirate a set amount of No. 1 eluent (injection water). The program controls the pneumatic control valve 4 to drive the drain valve switch 15 of the reaction module 16 to connect the waste liquid bottle 20 pipeline. Push the syringe and flush the syringe 13 and the pipeline of the reaction module 16 with the No. 1 eluent to reduce 99 the residual influence of the Mo feed solution.

[0051] 5. 99m Tc elution, neutralization, and adsorption by the guard column

[0052] The host computer 1 runs a program and controls the multi-channel switching valve 8 of the fully automatic molybdenum-99 / technetium-99m separation device 3 through communication via cable 22. The multi-channel switching valve 8 is switched to the eluent No. 1 bottle 10. The program controls the syringe module 14 to drive the syringe 13 to aspirate a set amount of No. 1 eluent (injection water). The program controls the pneumatic control valve 4 to drive the drain valve switch 15 of the reaction module 16 to connect the pipelines of the adsorption column 5, the exchange column (strong acid ion exchange column) 6, the guard column (acidic alumina guard column) 7, and the waste liquid bottle 20. The program controls the syringe module 14 to drive the syringe 13 to eject a set amount of No. 1 eluent, so that the No. 1 eluent sequentially passes through the adsorption column 5, the exchange column 6, and the guard column 7, and the waste liquid flows into the waste liquid bottle 20. Make 99m the Tc nuclide eluted from the adsorption column, neutralized by the exchange column reaction, and adsorbed and retained by the acidic guard column 5.

[0053] 6. Eluting the guard column to obtain sodium pertechnetate 99m Tc] injection

[0054] The host computer 1 runs a program and controls the multi-channel switching valve 8 of the fully automatic molybdenum-99 / technetium-99m separation device 3 through communication via cable 22. The multi-channel switching valve 8 is switched to the eluent No. 2 bottle 11. The program controls the syringe module 14 to drive the syringe 13 to aspirate a set amount of No. 2 eluent. The program controls the pneumatic control valve 4 to drive the drain valve switch 15 of the reaction module 16 to connect the guard column 7 and the product bottle 21. The program controls the syringe module 14 to drive the syringe 13 to eject a set amount of No. 2 eluent (0.9% NaCl injection solution), so that the No. 2 eluent sequentially passes through the guard column 7, and eluting the guard column 7 to obtain sodium pertechnetate 99m Tc] injection, and the solution is collected by the product bottle 21.

[0055] 7. Cleaning device

[0056] The host computer 1 runs a program and controls the multi-channel switching valve 8 of the fully automatic molybdenum-99 / technetium-99m separation device 3 through communication via the cable 22. The multi-channel switching valve 8 is switched to the eluent No. 1 bottle 10. The program controls the syringe module 14 to drive the syringe 13 to aspirate a set amount of the No. 1 eluent (injection water). The program controls the pneumatic control valve 4 to drive the drain valve switch 15 of the reaction module 16 to connect the pipelines of the guard column 7 and the waste liquid bottle 20. The program controls the syringe module 14 to drive the syringe 13 to eject a set amount of the No. 1 eluent, so that the No. 1 eluent sequentially passes through the guard column 7 and the waste liquid flows into the waste liquid bottle 20. In the same steps, gas is injected through the vent port to drive the residual liquid to flow into the waste liquid bottle 20.

[0057] Separation principle: The first adsorption column (adsorption column) is used to selectively adsorb pertechnetate ions and can be eluted with a suitable alkaline solvent. The second column (exchange column) is a strong acidic cation exchange column used to neutralize the alkalinity of the eluent in the previous step. The third column (guard column) is an acidic alumina column used to adsorb the slightly acidic pertechnetate ions in the previous step and can elute the pertechnetate ions with an NaCl solution to obtain 99m sodium pertechnetate

[0058] The above content is a specific description of the present invention in combination with specific embodiments, and it cannot be determined that the specific embodiments of the present invention are limited to these descriptions. For those of ordinary skill in the technical field to which the present invention pertains, without departing from the inventive concept, several simple deductions and transformations can still be made, which should all be regarded as belonging to the protection scope of the present invention.

Claims

1. A three-column trans-selective molybdenum-99 / technetium-99m generator device, which comprises a host computer (1), a fully automatic molybdenum-99 / technetium-99m separation device (3), a reaction module (16), a Mo-Tc feed liquid bottle (19), a product bottle (21), a liquid preparation solution bottle (9), a eluent No. 1 bottle (10), and a eluent No. 2 bottle (11), and is characterized in that the fully automatic molybdenum-99 / technetium-99m separation device (3) includes a chassis, an injection pump module (14), a multi-channel switching valve (8), a pneumatic control valve (4), and a reaction module slide table (17); the reaction module (16) includes a drain valve switch (15), a syringe (13), an adsorption column (5), an exchange column (6), and a protection column (7); the host computer is connected to the fully automatic molybdenum-99 / technetium-99m separation device (3) through a cable; the reaction module (16) is plugged into the drain valve slot of the reaction module slide table (17); the reaction module slide table (17) is arranged at the bottom of the front panel of the chassis; the pneumatic control valve (4) is arranged on the upper side of the reaction module slide table (17), and its position corresponds to the drain valve switch of the reaction module (16); the drain valve switch (15) is sleeved in the valve sleeve of the pneumatic control valve (4); the multi-channel switching valve (8) is arranged at the upper position of the front panel of the chassis, and the common port of the multi-channel switching valve (8) is connected to the liquid inlet of the reaction module (16) through a hose, and the other ports of the multi-channel switching valve (8) are respectively connected to the liquid preparation solution bottle (9), the eluent No. 1 bottle (10), and the eluent No. 2 bottle (11); the syringe (13) is cooperated with the injection pump module (14); the injection pump module (14) is arranged above the pneumatic control valve (4), right in front of the syringe (13); the Mo-Tc feed liquid bottle (19) and the product bottle (21) are respectively connected to the drain valve interfaces of the reaction module (16) through hoses; the adsorption column (5), the exchange column (6), and the protection column (7) are respectively connected to the reaction module (16).

2. The molybdenum-99 / technetium-99m generator device of the three-column inverse selection type according to claim 1, characterized in that, The processing and control component of the host computer (1) is a touch all-in-one computer; the touch all-in-one computer sets the parameters of each station through a touch screen (2) and monitors the operation of the separation system.

3. The molybdenum-99 / technetium-99m generator device of the three-column inverse selection type according to claim 1, characterized in that, The pneumatic control valve (4) includes 12 groups of pneumatic rotary swing cylinders (4-3), a valve sleeve (4-4), a pneumatic control valve island (4-2), and an I / O controller (4-1); the 12 groups of pneumatic rotary swing cylinders (4-3) are arranged on the upper side of the reaction module slide table (17), and their positions correspond to the drain valve switch (15); the 12 groups of pneumatic rotary swing cylinders (4-3) are assembled with the valve sleeve (4-4), and the valve sleeve (4-4) can be embedded into the corresponding drain valve switch (15); the pneumatic control valve island (4-2) is connected to the 12 groups of pneumatic rotary swing cylinders (4-3) through an air pipe, and the air drive interface of the pneumatic control valve island (4-2) is connected to the air circuit interface on the rear panel of the chassis; the I / O controller (4-1) is connected to the electric interface of the pneumatic control valve island (4-2), and the I / O controller (4-1) is connected to the data cable on the rear panel of the chassis.

4. The molybdenum-99 / technetium-99m generator device of the three-column inverse selection type according to claim 1, characterized in that, The device further includes a waste liquid collection bottle (20), and the waste liquid collection bottle (20) is respectively connected to the drain valve interface of the reaction module (16) through a hose.

5. The molybdenum-99 / technetium-99m generator device of the three-column inverse selection type according to claim 1, characterized in that, The device further includes a ventilation port (12), and the ventilation port (12) is arranged at one of the ports of the multi-channel switching valve (8).

6. The molybdenum-99 / technetium-99m generator device of the three-column inverse selection type according to claim 1, characterized in that, The adsorption column (5) is an adsorption column for solid-phase extraction, and the solid-phase extraction packing is made of activated carbon material; the exchange column (6) is a strongly acidic ion exchange column; the guard column (7) is an acidic alumina guard column.

7. A method for enriching 99 Tc nuclide from a low specific activity 99m Mo feed solution, characterized in that The method uses the three-column reverse selection type molybdenum-99 / technetium-99m generator device described in claim 1, and the method includes the following steps: (1) Device initialization: The upper computer runs a program, resets the injection pump module, multi-channel switching valve, and pneumatic control valve through cable communication. The program controls the operation of the pneumatic control valve and multi-channel switching valve. The liquid preparation solution bottle is connected to the syringe on the injection pump module through the multi-channel switching valve and a hose. The program controls the injection pump module to drive the syringe to operate, draw a set volume of the liquid preparation solution, and then drive the syringe to move to clean the pipelines of the entire device. (2) 99m Tc adsorption: The host computer controls the pneumatic control valve through cable communication by running a program, drives the discharge valve switch of the reaction module, connects the output port of the Mo-Tc liquid material bottle, the program controls the syringe module to drive the syringe, inhales a set amount of Mo-Tc liquid material, and through the control of the discharge valve switch of the reaction module, the syringe module drives the syringe to push the Mo-Tc liquid material into the adsorption column, so that 99m Tc is adsorbed in the material of the adsorption column, and then the Mo-Tc liquid material flows back to the Mo-Tc liquid material bottle through the input port of the Mo-Tc liquid material bottle; (3) 99 Mo washing: The host computer runs the program and controls the multi-channel switching valve through cable communication. The multi-channel switching valve is switched to the liquid preparation solution bottle, and the program controls the syringe module to drive the syringe to aspirate a set amount of the liquid preparation solution. Then, a set amount of the liquid preparation solution is pushed out through the adsorption column, and the liquid preparation solution flushes the residual Mo feed liquid on the material in the adsorption column. (4) 99m Tc elution, neutralization, and adsorption by the guard column: The host computer runs the program, controls the multi-channel switching valve through cable communication, switches the multi-channel switching valve to the eluent No. 1 bottle, the program controls the syringe module to drive the syringe, and inhales a set amount of the No. 1 eluent; the program controls the pneumatic control valve to drive the exhaust valve switch of the reaction module, connects the adsorption column, exchange column, and guard column; the program controls the syringe module to drive the syringe, and pushes out a set amount of the No. 1 eluent, so that the No. 1 eluent sequentially passes through the adsorption column, exchange column, and guard column; 99m The Tc nuclide is eluted from the adsorption column, undergoes a neutralization reaction through the exchange column, and is adsorbed and retained by the acidic guard column; (5) Elute the guard column to obtain sodium pertechnetate 99m Tc] injection: The host computer runs the program, controls the multi-channel switching valve through cable communication, switches the multi-channel switching valve to the eluent bottle No. 2, the program controls the syringe module to drive the syringe to aspirate a set amount of eluent No. 2; the program controls the pneumatic control valve to drive the discharge valve switch of the reaction module to connect the guard column and the product bottle; the program controls the syringe module to drive the syringe to eject a set amount of eluent No. 2, so that the eluent No. 2 sequentially passes through the guard column, elutes the guard column to obtain sodium pertechnetate 99m Tc] injection, and the solution is collected by the product bottle; (6) Cleaning the device: The upper computer runs a program, controls the multi-channel switching valve through cable communication, and the multi-channel switching valve switches to the eluent No. 1 bottle. The program controls the syringe module to drive the syringe to inhale a set amount of the No. 1 eluent; the program controls the pneumatic control valve to drive the drain valve switch of the reaction module to connect the guard column; the program controls the syringe module to drive the syringe to eject a set amount of the No. 1 eluent so that the No. 1 eluent sequentially passes through the guard column. The adsorption column is an adsorption column for solid-phase extraction, and the solid-phase extraction packing is made of activated carbon material; the exchange column is a strongly acidic ion exchange column; the guard column is an acidic alumina guard column; The liquid preparation solution is a NaOH solution with a concentration of 0.01 - 5 mol / L; the No. 1 eluent is injection water; the No. 2 eluent is an NaCl injection solution.

8. A method for enriching 99 Tc nuclide from a low specific activity 99m Mo feed solution, characterized in that The following steps are further included between step (3) and step (4): Pump head washing: The host computer runs the program, controls the multi-channel switching valve through cable communication. The multi-channel switching valve switches to the eluent No. 1 bottle 10. The program controls the syringe module to drive the syringe to aspirate a set amount of eluent No.

1. The program controls the pneumatic control valve to drive the drain valve switch of the reaction module to connect the waste liquid bottle pipeline. Push the syringe to rinse the syringe and the pipeline of the reaction module with eluent No. 1 to reduce 99 the residual influence of Mo feed liquid.

9. The method for enriching 99 Tc nuclide from a low specific activity 99m Mo feed solution, characterized in that The method further includes the following steps: When waste liquid is generated, the program controls the pneumatic control valve to drive the drain valve switch of the reaction module to connect the waste liquid bottle pipeline so that the waste liquid flows into the waste liquid bottle.

10. The method for enriching 99 Tc nuclide from the low specific activity 99m Mo feed solution according to claim 7, characterized in that Step (1) and step (6) respectively further include the following steps: The program controls the multi-channel switching valve to connect the ventilation port, and uses gas to drive the residual liquid to flow into the waste liquid bottle.

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