Two-column inverse selection type molybdenum-99 / technetium-99m generator device and separation method

Abstract

The present invention relates to a two-column inverse selection type molybdenum-99 / technetium-99m generator device and a separation method. The device includes a host computer (1), a fully automatic molybdenum-99 / technetium-99m separation device (3), a two-column reaction module (16), a Mo-Tc feed liquid bottle (19), a product bottle (21), a liquid preparation solution bottle (9), an eluent No. 1 bottle (10), and an eluent No. 2 bottle (11). The fully automatic molybdenum-99 / technetium-99m separation device (3) includes a chassis (5), an injection pump module (14), a multi-channel switching valve (8), a pneumatic control valve (4), and a reaction module slide (17). The two-column reaction module (16) includes a drain valve switch (15), a syringe (13), an adsorption column (6), and a guard column (7). The device has the characteristics of high automation degree, fast preparation speed, high separation rate, etc. The high automation degree also reduces the radiation impact of radioactive radiation on operators.

Description

Technical Field

[0001] The present invention belongs to the field of isotope radioactive production, and specifically relates to a method for producing radioactive isotopes from low specific activity 99 Enriched in the mold liquid 99m The automated device for Tc nuclides - a two-column trans-selective Mo-99-Technetium-99m generator, is used to prepare high-technetium that meets the requirements of the pharmacopoeia. 99m Sodium Tc] acid injection. Background Art

[0002] Currently high specific activity 99 Mo (about 50000Ci / g Mo) is produced by uranium fission. The world's highest specific activity 99 Mo is mainly provided by reactors in countries such as the Netherlands, Belgium, France, South Africa, Australia and Russia. When reactors in major producing countries are shut down for maintenance or decommissioning, fission 99 Mo supply may face shortages.

[0003] Non-fission production 99 Mo usually 98 Mohe 100 Mo is used as raw material and is prepared by irradiation in a reactor or an accelerator. 99 Mo activity is low (1-10Ci / g Mo), non-radioactive Mo is overwhelmingly dominant, and normal fission is used. 99 Mo- 99m Tc generator obtained 99m Tc eluent 99m The Tc concentration is too low to meet the pharmacopoeia requirements. Therefore, it is necessary to develop a low specific activity 99 Enriched in the mold liquid 99m Currently, there is no fully automatic Mo-99-Technetium-99m preparation device developed for the two-column separation and purification technology. Summary of the invention

[0004] For low specific activity in background technology 99 Extraction of Mo from liquid 99m The present invention aims to provide a novel fully automatic two-column trans-selective Mo-99-Technetium-99m generator device to solve the problem of Tc nuclides. The inventors used activated carbon materials treated with alkali solution (soaked in alkali solution and dried) as the filler of SPE columns, making them suitable for adsorption in neutral solutions. 99m Tc, so the high technetium eluted from the SPE adsorption column [ 99m The sodium tc] acid solution is neutral and can be directly adsorbed on the acidic alumina adsorption column without being neutralized by the SCX exchange column without changing the properties of the acidic alumina.

[0005] To achieve the above object, the present invention provides the following technical solutions:

[0006] A two-column trans-selective molybdenum-99 / technetium-99m generator device, which includes a host computer (1), a fully automatic molybdenum-99 / technetium-99m separation device (3), a two-column reaction module (16), a Mo-Tc feed liquid bottle (19), a product bottle (21), a liquid preparation solution bottle (9), a eluent No. 1 bottle (10), and a eluent No. 2 bottle (11). The fully automatic molybdenum-99 / technetium-99m separation device (3) includes a chassis (5), an injection pump module (14), a multi-channel switching valve (8), a pneumatic control valve (4), and a reaction module slide (17); the two-column reaction module (16) includes a drain valve switch (15), a syringe (13), an adsorption column (6), and a guard column (7).

[0007] The host computer is connected to the fully automatic molybdenum-99 / technetium-99m separation device (3) through a cable; the two-column reaction module (16) is plugged into the drain valve slot of the reaction module slide (17); the reaction module slide (17) is arranged at the bottom of the front panel of the chassis; the pneumatic control valve (4) is arranged above the reaction module slide (17), and its position corresponds to the drain valve switch of the two-column reaction module (16); the drain valve switch (15) is sleeved in the valve sleeve of the pneumatic control valve (4); the multi-channel switching valve (8) is arranged above the front panel of the chassis. The common port of the multi-channel switching valve (8) is connected to the inlet of the two-column reaction module (16) through a hose, and the other ports of the multi-channel switching valve (8) are respectively connected to the liquid preparation solution bottle (9), the eluent No. 1 bottle (10), and the eluent No. 2 bottle (11); the syringe (13) is matched with the injection pump module (14); the injection pump module (14) is arranged above the pneumatic control valve (4), right in front of the syringe (13); the Mo-Tc feed liquid bottle (19) and the product bottle (21) are respectively connected to the drain valve interfaces of the two-column reaction module (16) through hoses; the adsorption column (6) and the guard column (7) are respectively connected to the two-column reaction module (16).

[0008] As a preferred solution, the processing and control component of the host computer (1) is a touch all-in-one computer; the touch all-in-one computer sets the parameters of each station through a touch screen (2) and monitors the operation of the separation system.

[0009] As a preferred solution, the pneumatic control valve (4) includes 10 groups of pneumatic rotary swing cylinders (4-3), valve sleeves (4-4), pneumatic control valve islands (4-2), and I / O controllers (4-1).

[0010] The 10 groups of pneumatic rotary swing cylinders (4-3) are arranged on the upper side of the reaction module slide table (17) and correspond to the positions of the drain valve switches (15); the 10 groups of pneumatic rotary swing cylinders (4-3) are assembled with the valve sleeves (4-4), and the valve sleeves (4-4) can be embedded into the corresponding drain valve switches (15); the pneumatic control valve island (4-2) is connected to the 10 groups of pneumatic rotary swing cylinders (4-3) through air pipes, and the air drive interface of the pneumatic control valve island (4-2) is connected to the air path interface on the rear panel of the chassis; the I / O controller (4-1) is connected to the electric interface of the pneumatic control valve island (4-2), and the I / O controller (4-1) is connected to the data cable on the rear panel of the chassis.

[0011] As a preferred solution, the device further includes a waste liquid collection bottle (20), and the waste liquid collection bottle (20) is respectively connected to the drain valve interfaces of the two-column reaction module (16) through hoses.

[0012] As a preferred solution, the device further includes a ventilation port (12), and the ventilation port (12) is arranged at one of the ports of the multi-channel switching valve (8).

[0013] As a preferred solution, the adsorption column (6) is a solid-phase extraction adsorption column, and the solid-phase extraction packing is an activated carbon material treated with alkali solution (soaked in alkali solution and dried); the guard column (7) is an acidic alumina guard column.

[0014] The second object of the present invention is to provide a method for enriching 99 Tc nuclide from a low specific activity 99m Mo feed solution. The method uses the two-column trans-selective molybdenum-99 / technetium-99m generator device as described above, and the method includes the following steps:

[0015] (1) Device initialization: The host computer runs the program, resets the injection pump module, multi-channel switching valve, and pneumatic control valve through cable communication. The program controls the operation of the pneumatic control valve and multi-channel switching valve. The liquid dispensing solution bottle is connected to the syringe on the injection pump module through the multi-channel switching valve and hose. The program controls the injection pump module to drive the syringe to operate, draw a set volume of liquid dispensing solution, and then drive the syringe to move to clean the pipelines of the entire device.

[0016] (2) 99m Tc adsorption: The host computer controls the pneumatic control valve through running the program and cable communication, drives the drain valve switch of the two-column reaction module, and connects the output port of the Mo-Tc feed solution bottle. The program controls the syringe module to drive the syringe to inhale a set amount of Mo-Tc feed solution. Through the control of the drain valve switch of the two-column reaction module, the syringe module drives the syringe to push the Mo-Tc feed solution into the adsorption column, so that 99mTc is adsorbed inside the material of the adsorption column, and then the Mo-Tc feed solution flows back into the Mo-Tc feed solution bottle through the Mo-Tc feed solution bottle inlet;

[0017] (3) 99 Mo washing: The host computer runs the program, controls the multi-channel switching valve through cable communication. The multi-channel switching valve switches to the dispensing solution bottle. The program controls the syringe module to drive the syringe to aspirate a set amount of dispensing solution; then it pushes out a set amount of dispensing solution through the adsorption column, and the dispensing solution flushes the residual Mo feed solution on the material in the adsorption column;

[0018] (4) 99m Tc elution and adsorption by the guard column: The host computer runs the program, controls the multi-channel switching valve through cable communication. The multi-channel switching valve switches to the eluent No. 1 bottle. The program controls the syringe module to drive the syringe to aspirate a set amount of eluent No. 1; the program controls the pneumatic control valve to drive the drain valve switch of the two-column reaction module to connect the adsorption column and the guard column; the program controls the syringe module to drive the syringe to push out a set amount of eluent No. 1, so that eluent No. 1 sequentially passes through the adsorption column and the guard column; so that 99m The Tc radionuclide is eluted from the adsorption column and adsorbed and retained by the acidic guard column;

[0019] (5) Eluting the guard column to obtain sodium pertechnetate 99m Tc] injection: The host computer runs the program, controls the multi-channel switching valve through cable communication. The multi-channel switching valve switches to the eluent No. 2 bottle. The program controls the syringe module to drive the syringe to aspirate a set amount of eluent No. 2; the program controls the pneumatic control valve to drive the drain valve switch of the two-column reaction module to connect the acidic guard column and the product bottle; the program controls the syringe module to drive the syringe to push out a set amount of eluent No. 2, so that eluent No. 2 sequentially passes through the guard column, and eluting the guard column to obtain sodium pertechnetate 99m Tc] injection, and the solution is collected by the product bottle;

[0020] (6) Cleaning device: The host computer runs the program, controls the multi-channel switching valve through cable communication. The multi-channel switching valve switches to the eluent No. 1 bottle. The program controls the syringe module to drive the syringe to aspirate a set amount of eluent No. 1; the program controls the pneumatic control valve to drive the drain valve switch of the two-column reaction module to connect the guard column; the program controls the syringe module to drive the syringe to push out a set amount of eluent No. 1, so that eluent No. 1 sequentially passes through the guard column;

[0021] The adsorption column is a solid-phase extraction adsorption column, and the solid-phase extraction packing is an activated carbon material treated with alkali solution; the guard column is an acidic alumina guard column;

[0022] The dispensing solution is a NaOH solution with a concentration of 0.01 - 5 mol / L; the No. 1 eluent is injection water; the No. 2 eluent is an NaCl injection solution.

[0023] As a preferred solution, between step (3) and step (4), the following steps are further included:

[0024] Pump head washing: The upper computer runs a program, controls the multi-channel switching valve through cable communication. The multi-channel switching valve switches to the No. 1 eluent bottle 10. The program controls the syringe module to drive the syringe to aspirate a set amount of the No. 1 eluent; the program controls the pneumatic control valve to drive the drain valve switch of the two-column reaction module to connect the waste liquid bottle pipeline; push the syringe to wash the syringe and the pipeline of the reaction module with the No. 1 eluent to reduce 99 the residual influence of the Mo feed solution.

[0025] As a preferred solution, the method further includes the following steps:

[0026] When waste liquid is generated, the program controls the pneumatic control valve to drive the drain valve switch of the two-column reaction module to connect the waste liquid bottle pipeline, so that the waste liquid flows into the waste liquid bottle.

[0027] As a preferred solution, step (1) and step (6) respectively further include the following steps:

[0028] The program controls the multi-channel switching valve to connect to the vent port, and uses gas to drive the residual liquid to flow into the waste liquid bottle.

[0029] The beneficial effects of the present invention are as follows:

[0030] The two-column trans-selective molybdenum-99 / technetium-99m generator device provided by the present invention has a high degree of automation. Only by programming the program flow block according to the determined process flow, the two-column trans-selective molybdenum-99 / technetium-99m generator device can complete actions according to the corresponding process program; the preparation speed has been greatly improved compared with the manual separation and purification operation of chemical experimental containers, and the liquid volume control accuracy is much higher than that of a peristaltic pump for controlling the liquid volume. The two-column trans-selective molybdenum-99 / technetium-99m generator device reduces human intervention and also reduces the irradiation effect of radioactive radiation on operators. Description of the Drawings

[0031] Figure 1 is a structural schematic diagram of a two-column trans-selective molybdenum-99 / technetium-99m generator device;

[0032] Figure 2 is a connection schematic diagram of a fully automatic molybdenum-99 / technetium-99m separation device;

[0033] In the figure, 1 - host computer; 2 - touch screen; 3 - fully automatic molybdenum-99 / technetium-99m separation device; 4 - pneumatic control valve; 5 - chassis; 6 - adsorption column; 7 - guard column; 8 - multi-channel switching valve; 9 - liquid preparation solution bottle; 10 - eluent bottle No. 1; 11 - eluent bottle No. 2; 12 - vent; 13 - syringe; 14 - injection pump module; 15 - drain valve switch; 16 - two-column reaction module; 17 - reaction module slide; 18 - locking switch; 19 - Mo-Tc feed solution bottle; 20 - waste liquid bottle; 21 - product bottle; 22 - cable; 23 - hose; 24 - data interface; 4-1 - I / O controller; 4-2 - pneumatic control valve island; 4-3 - pneumatic rotary swing cylinder; 4-4 - valve sleeve. Detailed implementation mode

[0034] The following combines the drawings and the implementation mode to elaborate in detail on the specific implementation plan of the present invention.

[0035] The present invention provides a two-column trans-selective molybdenum-99 / technetium-99m generator device, the structure is as Figure 1 shown, including a host computer 1, a fully automatic molybdenum-99 / technetium-99m separation device 3, a two-column reaction module 16, a Mo-Tc feed solution bottle 19, a product bottle 21, a waste liquid bottle 20, etc.

[0036] The host computer 1 adopts an embedded operating system, and a touch all-in-one computer is used as the host computer processing and control component. The main controller of the touch all-in-one computer is connected to the fully automatic molybdenum-99 / technetium-99m separation device 3 through a cable 22, mainly controlling the operation of the multi-channel switching valve 8, the pneumatic control valve 4, and the injection pump module 14 in the molybdenum-99 / technetium-99m separation device 3. The touch all-in-one computer sets the parameters of each station through the touch screen 2 and monitors the operation of the separation system.

[0037] The two-column reaction module 16 is a module combination assembled according to the determined two-column trans-selective low-activity molybdenum-99 / technetium-99m separation and purification process flow. The two-column reaction module 16 includes a drain valve switch 15, a syringe 13, an adsorption column 6, a guard column 7, a hose 23, etc.

[0038] The two-column reaction module 16 is a replaceable structure, plugged into the drain valve slot on the reaction module slide 17 of the fully automatic molybdenum-99 / technetium-99m separation device. The drain valve switch 15 of the two-column reaction module 16 is sleeved in the pneumatic control valve 4 of the fully automatic molybdenum-99 / technetium-99m device 3. The pneumatic control valve 4 is driven to act through software control, realizing the shut-off of the drain valve switch 15 of the two-column reaction module 16, and completing the separation and purification process of the set process flow by flowing through the multiphase formulation liquid.

[0039] The fully automatic molybdenum-99 / technetium-99m separation device 3 consists of a chassis 5, an injection pump module 14, a multi-channel switching valve 8, a pneumatic control valve 4, a reaction module slide 17, etc. Inside the chassis 5, there is a pneumatic control valve island 4-2 that drives the pneumatic rotary swing cylinder 4-3 and an I / O controller 4-1. The reaction module slide 17 is installed at the bottom of the front panel of the chassis. There is a drain valve slot on the reaction module slide 17, into which a two-column reaction module 16 can be inserted. The reaction module slide 17 can slide back and forth, and the two-column reaction module 16 can be docked with the pneumatic control valve 4 as the reaction module slide 17 is pushed forward.

[0040] The pneumatic control valve 4 consists of 10 groups of pneumatic rotary swing cylinders 4-3, a valve sleeve 4-4, a pneumatic control valve island 4-2, and an I / O controller 4-1.

[0041] The 10 groups of pneumatic rotary swing cylinders 4-3 are installed on the upper side of the reaction module slide 17 on the front panel of the chassis 5. The positions of the 10 groups of pneumatic rotary swing cylinders 4-3 correspond to the positions of the drain valve switches 15 of the reaction module 16. The 10 groups of pneumatic rotary swing cylinders 4-3 are assembled with the valve sleeve 4-4, and the valve sleeve 4-4 can be inserted into the drain valve switch 15 of the corresponding reaction module 16 to achieve the corresponding actions of the drain valve switch 15.

[0042] The 10 groups of pneumatic rotary swing cylinders 4-3 are connected to the pneumatic control valve island 4-2 through air pipes. The air drive interface of the pneumatic control valve island 4-2 is connected to the air path interface on the rear panel of the chassis, and the electric interface of the pneumatic control valve island 4-2 is connected to the I / O controller 4-1. The I / O controller 4-1 is connected to the data cable 22 on the rear panel of the chassis, and the I / O controller 4-1 is controlled through the program software of the host computer 1. After the reaction module slide 17 is pushed forward, the locking switch 18 of the reaction module slide 17 is rotated, and the syringe 13 on the reaction module 16 cooperates with the injection pump module 14. The injection pump module is located above the pneumatic control valve and is directly opposite the syringe position of the reaction module. The multi-channel switching valve 8 is installed at the upper position of the front panel of the chassis. The common port of the multi-channel switching valve 8 is connected to the liquid inlet of the reaction module 16 through a hose 23, and the other ports of the multi-channel switching valve 8 are respectively connected to the liquid preparation solution bottle 9, the eluent No. 1 bottle 10, the eluent No. 2 bottle 11, and the air vent 12.

[0043] Combined with the characteristics of the developed two-column reverse-phase selection type separation and purification process and the operating environment, the fully automatic elution process is used for operation description:

[0044] 1. Device initialization

[0045] The host computer 1 runs a program and communicates through cable 22 to reset the injection pump module 14, multi-channel switching valve 8, and pneumatic control valve 4 of the fully automatic molybdenum-99 / technetium-99m separation device 3. The program controls the operation of the pneumatic control valve 4 and the multi-channel switching valve 8. The liquid dispensing solution bottle 9 can be connected to the syringe 13 on the injection pump module 14 through the multi-channel switching valve 8 and the hose 23. The program controls the injection pump module 14 to drive the syringe 13 to operate. After extracting a set volume of the liquid dispensing solution (NaOH solution with a concentration of 0.01 - 5 mol / L), the program drives the syringe 13 to move, cleaning the pipelines of the entire device, and the liquid flows into the waste liquid bottle 20. The program controls the multi-channel switching valve 8 to connect to the ventilation port 12, and uses gas to drive the residual liquid in the hose 23 to be discharged.

[0046] 2. 99m Tc adsorption process

[0047] The host computer 1 runs a program and communicates through cable 22 to control the pneumatic control valve 4 of the fully automatic molybdenum-99 / technetium-99m separation device 3, driving the drain valve switch 15 of the two-column reaction module 16 to connect to the output port of the Mo-Tc feed liquid bottle 19. The program controls the syringe module 14 to drive the syringe 13 to inhale a set amount of Mo-Tc feed liquid. Through the control of the drain valve switch 15 of the two-column reaction module 16, the syringe module 14 drives the syringe 13 to push the Mo-Tc feed liquid into the adsorption column 6 of the solid-phase extraction, enabling 99m Tc to be adsorbed in the material of the adsorption column 6, and then the Mo-Tc feed liquid flows back to the Mo-Tc feed liquid bottle 19 through the input port of the Mo-Tc feed liquid bottle 19.

[0048] 3. 99 Mo washing process

[0049] The host computer 1 runs a program and communicates through cable 22 to control the multi-channel switching valve 8 of the fully automatic molybdenum-99 / technetium-99m separation device 4. The multi-channel switching valve 8 is switched to the liquid dispensing solution bottle 9. The program controls the syringe module 14 to drive the syringe 13 to inhale a set amount of the liquid dispensing solution (NaOH solution with a concentration of 0.01 - 5 mol / L). The program controls the pneumatic control valve 4 to drive the drain valve switch 15 of the two-column reaction module 16, connecting the adsorption column 6 to the pipeline of the waste liquid bottle 20. The program controls the syringe module 14 to drive the syringe 13 to push out a set amount of the liquid dispensing solution through the adsorption column 6. The liquid dispensing solution flushes the residual Mo feed liquid on the material in the adsorption column 6, and the waste liquid flows into the waste liquid bottle 20 through the pipeline of the reaction module 16.

[0050] 4. Pump head washing process

[0051] The host computer 1 runs a program and controls the multi-channel switching valve 8 of the fully automatic molybdenum-99 / technetium-99m separation device 3 through communication via cable 22. The multi-channel switching valve 8 is switched to the eluent No. 1 bottle 10. The program controls the syringe module 14 to drive the syringe 13 to aspirate a set amount of the No. 1 eluent (injectable water). The program controls the pneumatic control valve 4 to drive the drain valve switch 15 of the two-column reaction module 16 to connect the waste liquid bottle 20 pipeline. Push the syringe, and the No. 1 eluent flushes the pipeline of the syringe 13 and the reaction module 16 to reduce 99 the residual influence of the Mo feed solution.

[0052] 5. 99m Tc elution and adsorption by the guard column

[0053] The host computer 1 runs a program and controls the multi-channel switching valve 8 of the fully automatic molybdenum-99 / technetium-99m separation device 3 through communication via cable 22. The multi-channel switching valve 8 is switched to the eluent No. 1 bottle 10. The program controls the syringe module 14 to drive the syringe 13 to aspirate a set amount of the No. 1 eluent (injectable water). The program controls the pneumatic control valve 4 to drive the drain valve switch 15 of the two-column reaction module 16 to connect the adsorption column 6, the guard column (acidic alumina guard column) 7 and the waste liquid bottle 20 pipeline. The program controls the syringe module 14 to drive the syringe 13 to eject a set amount of the No. 1 eluent, so that the No. 1 eluent sequentially passes through the adsorption column 6 and the guard column 7, and the waste liquid flows into the waste liquid bottle 20. Make 99m the Tc nuclide eluted from the adsorption column and adsorbed and retained when passing through the acidic guard column 7.

[0054] 6. Eluting the guard column to obtain sodium pertechnetate 99m Tc] injection solution

[0055] The host computer 1 runs a program and controls the multi-channel switching valve 8 of the fully automatic molybdenum-99 / technetium-99m separation device 3 through communication via cable 22. The multi-channel switching valve 8 is switched to the eluent No. 2 bottle 11. The program controls the syringe module 14 to drive the syringe 13 to aspirate a set amount of the No. 2 eluent (0.9% NaCl injection solution). The program controls the pneumatic control valve 4 to drive the drain valve switch 15 of the two-column reaction module 16 to connect the acidic guard column 7 and the product bottle 21. The program controls the syringe module 14 to drive the syringe 13 to eject a set amount of the 0.9% NaCl injection solution, so that the No. 2 eluent sequentially passes through the guard column 7, and eluting the guard column 7 to obtain sodium pertechnetate 99m Tc] injection solution, and the solution is collected by the product bottle 21.

[0056] 7. Cleaning device

[0057] The host computer 1 runs a program and controls the multi-channel switching valve 8 of the fully automatic molybdenum-99 / technetium-99m separation device 3 through communication via cable 22. The multi-channel switching valve 8 is switched to the eluent No. 1 bottle 10, and the program controls the syringe module 14 to drive the syringe 13 to aspirate a set amount of No. 1 eluent (injection water). The program controls the pneumatic control valve 4 to drive the discharge valve switch 15 of the two-column reaction module 16 to connect the pipelines of the guard column 7 and the waste liquid bottle 20. The program controls the syringe module 14 to drive the syringe 13 to eject a set amount of No. 1 eluent, so that the injection water sequentially passes through the guard column 7 and the waste liquid flows into the waste liquid bottle 20. In the same steps, gas is injected through the vent port to drive the residual liquid to flow into the waste liquid bottle 20.

[0058] Separation principle: Mo in the Mo-Tc feed solution exists in the form of MoO4 2- with two negative charges; Tc exists in the form of TcO4 - with one negative charge. After treatment with alkali solution, there are a large number of exposed electronegative basic groups on the surface of the activated carbon material. The activated carbon material itself has hydrophobicity, so it has an attraction for hydrophobic MoO4 2- and TcO4 - in aqueous solution. At the same time, since the activated carbon material and the two ions are both electronegative, there is also a repulsive force. The repulsive force of the activated carbon material for MoO4 2- is greater than the attractive force, so MoO4 2- is not adsorbed; the repulsive force of the activated carbon material for TcO4 - is less than the attractive force, so TcO4 - is adsorbed.

[0059] The packing of the guard column is acidic alumina. MoO4 2- will be strongly adsorbed by groups such as coordination unsaturated sites (-Al 3+ -), while the attractive force on TcO4 - is relatively weak. When eluting with sodium chloride injection, Cl - in the eluent can exchange the adsorbed TcO4 - without affecting MoO4 2- , thus obtaining a sodium pertechnetate 99m Tc] solution.

[0060] The above content is a specific description of the present invention in combination with specific implementation manners. It cannot be determined that the specific implementation manners of the present invention are limited to these descriptions. For those of ordinary skill in the technical field to which the present invention belongs, without departing from the inventive concept, several simple deductions and transformations can still be made, and all should be regarded as belonging to the protection scope of the present invention.

Claims

1. A two-column trans-selective molybdenum-99 / technetium-99m generator device, the device comprising a host computer (1), a fully automatic molybdenum-99 / technetium-99m separation device (3), a two-column reaction module (16), a Mo-Tc feed liquid bottle (19), a product bottle (21), a liquid preparation solution bottle (9), a eluent bottle No. 1 (10), and a eluent bottle No. 2 (11), characterized in that the fully automatic molybdenum-99 / technetium-99m separation device (3) includes a chassis (5), an injection pump module (14), a multi-channel switching valve (8), a pneumatic control valve (4), and a reaction module slide (17); the two-column reaction module (16) includes a drain valve switch (15), a syringe (13), an adsorption column (6), and a guard column (7); the host computer is connected to the fully automatic molybdenum-99 / technetium-99m separation device (3) through a cable; the two-column reaction module (16) is plugged into the drain valve slot of the reaction module slide (17); the reaction module slide (17) is arranged at the bottom of the front panel of the chassis; the pneumatic control valve (4) is arranged above the reaction module slide (17), and its position corresponds to the drain valve switch of the two-column reaction module (16); the drain valve switch (15) is sleeved in the valve sleeve of the pneumatic control valve (4); the multi-channel switching valve (8) is arranged above the front panel of the chassis, the common port of the multi-channel switching valve (8) is connected to the liquid inlet of the two-column reaction module (16) through a hose, and the other ports of the multi-channel switching valve (8) are respectively connected to the liquid preparation solution bottle (9), the eluent bottle No. 1 (10), and the eluent bottle No. 2 (11); the syringe (13) is matched with the injection pump module (14); the injection pump module (14) is arranged above the pneumatic control valve (4), right in front of the syringe (13); the Mo-Tc feed liquid bottle (19) and the product bottle (21) are respectively connected to the drain valve interfaces of the two-column reaction module (16) through hoses; the adsorption column (6) and the guard column (7) are respectively connected to the two-column reaction module (16).

2. The two-column inverse selection type molybdenum-99 / technetium-99m generator device according to claim 1, characterized in that, The processing and control component of the host computer (1) is a touch all-in-one computer; the touch all-in-one computer sets the parameters of each station through a touch screen (2) and monitors the operation of the separation system.

3. The two-column inverse selection type molybdenum-99 / technetium-99m generator device according to claim 1, characterized in that, The pneumatic control valve (4) includes 10 groups of pneumatic rotary swing cylinders (4-3), valve sleeves (4-4), pneumatic control valve islands (4-2), and I / O controllers (4-1); The described 10 groups of pneumatic rotary swing cylinders (4-3) are arranged on the upper side of the reaction module slide table (17) and correspond to the positions of the drain valve switches (15); the 10 groups of pneumatic rotary swing cylinders (4-3) are assembled with the valve sleeves (4-4), and the valve sleeves (4-4) can be embedded into the corresponding drain valve switches (15); the pneumatic control valve island (4-2) is connected to the 10 groups of pneumatic rotary swing cylinders (4-3) through air pipes, and the air drive interface of the pneumatic control valve island (4-2) is connected to the air path interface on the rear panel of the chassis; the I / O controller (4-1) is connected to the electric interface of the pneumatic control valve island (4-2), and the I / O controller (4-1) is connected to the data cable on the rear panel of the chassis.

4. The two-column inverse selection type molybdenum-99 / technetium-99m generator device according to claim 1, characterized in that, The device further includes a waste liquid collection bottle (20), and the waste liquid collection bottle (20) is respectively connected to the drain valve interfaces of the two-column reaction module (16) through hoses.

5. The two-column inverse selection type molybdenum-99 / technetium-99m generator device according to claim 1, characterized in that, The device further includes a ventilation port (12), and the ventilation port (12) is arranged at one port of the multi-channel switching valve (8).

6. The two-column inverse selection type molybdenum-99 / technetium-99m generator device according to claim 1, wherein, The adsorption column (6) is a solid-phase extraction adsorption column, and the solid-phase extraction packing is activated carbon material treated with alkaline solution; the guard column (7) is an acidic alumina guard column.

7. A method for enriching 99 Tc radionuclide from a low specific activity 99m Mo feed solution, characterized in that The method uses the two-column reverse selection type molybdenum-99 / technetium-99m generator device described in claim 1, and the method includes the following steps: (1) Device initialization: The host computer runs a program to reset the injection pump module, multi-channel switching valve, and pneumatic control valve through cable communication. The program controls the operation of the pneumatic control valve and multi-channel switching valve. The liquid dispensing solution bottle is connected to the syringe on the injection pump module through the multi-channel switching valve and hose. The program controls the injection pump module to drive the syringe to operate. After extracting a set volume of the liquid dispensing solution, the syringe is pushed to move to clean the pipelines of the entire device. (2) 99m Tc adsorption: The host computer controls the pneumatic control valve through cable communication by running a program, drives the discharge valve switch of the two-column reaction module, connects the output port of the Mo-Tc liquid material bottle, the program controls the syringe module to drive the syringe, inhales a set amount of Mo-Tc liquid material, and through the control of the discharge valve switch of the two-column reaction module, the syringe module drives the syringe to push the Mo-Tc liquid material into the adsorption column, so that 99m Tc is adsorbed in the material of the adsorption column, and then the Mo-Tc liquid material flows back into the Mo-Tc liquid material bottle through the input port of the Mo-Tc liquid material bottle; (3) 99 Mo washing: The host computer runs the program and controls the multi-channel switching valve through cable communication. The multi-channel switching valve is switched to the liquid dispensing solution bottle. The program controls the syringe module to drive the syringe to suck a set amount of the liquid dispensing solution. Then, a set amount of the liquid dispensing solution is pushed out through the adsorption column, and the liquid dispensing solution flushes the residual Mo feed liquid on the material in the adsorption column. (4) 99m Tc elution and adsorption by the guard column: The host computer runs the program, controls the multi-channel switching valve through cable communication. The multi-channel switching valve is switched to the eluent bottle No.

1. The program controls the syringe module to drive the syringe to aspirate a set amount of eluent No.

1. The program controls the pneumatic control valve to drive the exhaust valve switch of the two-column reaction module to connect the adsorption column and the guard column. The program controls the syringe module to drive the syringe to eject a set amount of eluent No. 1, so that eluent No. 1 sequentially passes through the adsorption column and the guard column; 99m The Tc nuclide is eluted from the adsorption column and adsorbed and retained by the acidic guard column; (5) Elute the guard column to obtain sodium pertechnetate 99m Tc] injection solution: The host computer runs the program, controls the multi-channel switching valve through cable communication, switches the multi-channel switching valve to the 2nd bottle of eluent, the program controls the syringe module to drive the syringe to aspirate a set amount of the 2nd eluent; the program controls the pneumatic control valve to drive the drain valve switch of the two-column reaction module, connects the acidic guard column and the product bottle; the program controls the syringe module to drive the syringe to eject a set amount of the 2nd eluent, so that the 2nd eluent sequentially passes through the guard column, elutes the guard column to obtain sodium pertechnetate 99m Tc] injection solution, and the solution is collected by the product bottle; (6) Cleaning the device: The host computer runs a program to control the multi-channel switching valve through cable communication. The multi-channel switching valve is switched to the eluent No. 1 bottle. The program controls the syringe module to drive the syringe to inhale a set amount of the No. 1 eluent; the program controls the pneumatic control valve to drive the drain valve switch of the two-column reaction module to connect the guard column; the program controls the syringe module to drive the syringe to push out a set amount of the No. 1 eluent, so that the No. 1 eluent sequentially passes through the guard column. The adsorption column is a solid-phase extraction adsorption column, and the solid-phase extraction packing is activated carbon material treated with alkaline solution; the guard column is an acidic alumina guard column; The liquid dispensing solution is a NaOH solution with a concentration of 0.01 - 5 mol / L; the No. 1 eluent is injection water; the No. 2 eluent is NaCl injection solution.

8. The method for enriching 99 Tc nuclide from a low specific activity 99m Mo feed solution according to claim 7, characterized in that Between step (3) and step (4), the following steps are further included: Pump head washing: The host computer runs the program, controls the multi-channel switching valve through cable communication. The multi-channel switching valve is switched to the eluent No. 1 bottle. The program controls the syringe module to drive the syringe to aspirate a set amount of eluent No.

1. The program controls the pneumatic control valve to drive the drain valve switch of the two-column reaction module to connect the waste liquid bottle pipeline. Push the syringe to wash the syringe and the pipeline of the reaction module with eluent No. 1 to reduce 99 the residual influence of Mo feed liquid.

9. The method for enriching 99 Tc nuclide from a 99m Mo feed solution with low specific activity according to claim 7, characterized in that The method further includes the following steps: When waste liquid is generated, the program controls the pneumatic control valve to drive the drain valve switch of the two-column reaction module to connect the waste liquid bottle pipeline, so that the waste liquid flows into the waste liquid bottle.

10. The method for enriching 99 Tc nuclide from a low specific activity 99m Mo feed solution, characterized in that Step (1) and step (6) respectively further include the following steps: The program controls the multi-channel switching valve to connect the ventilation port, and uses gas to drive the residual liquid to flow into the waste liquid bottle.

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