A ring-shaped high-throughput microfluidic platform and its application

Abstract

The present invention relates to a ring-shaped high-throughput microfluidic platform and application, belonging to the field of microfluidic technology, the platform comprises an inlet distributor, a stimulation chamber A, a connecting distributor, a stimulation chamber B, an outlet distributor and a collector, wherein the inlet distributor is connected to the stimulation chamber A, the inlet distributor is connected to the connecting distributor through the stimulation chamber A, one end of the inner capillary is connected to the inlet distributor, the other end passes through the stimulation chamber A to be connected to the connecting distributor, the connecting distributor is connected to the stimulation chamber B, the connecting distributor is connected to the outlet distributor through the stimulation chamber B, one end of the outer capillary is connected to the inner capillary on the connecting distributor, the other end passes through the stimulation chamber B to be connected to the outlet distributor, and the outlet distributor is connected to the collector. The present invention realizes the production and synthesis of small-scale nanoparticle materials through built-in stimulation conditions, and has a compact structure, and solves the technical problem of multiple pumps for inlet through the distribution mechanism.

Description

Technical Field

[0001] The invention relates to an annular high-throughput microfluidic platform and application thereof, belonging to the technical field of microfluidic control. Background Art

[0002] Microfluidics refers to the science and technology involved in systems that use microchannels (tens to hundreds of microns in size) to process or manipulate tiny fluids (nanoliter to attoliter in volume). It is an emerging interdisciplinary subject involving chemistry, fluid physics, microelectronics, new materials, biology and biomedical engineering. The microfluidic platform is a multifunctional platform that performs micron-scale fluid control. Currently, there are a variety of manufacturing technologies used to manufacture these microfluidic devices for the production of nanoparticles, the most common of which is made with PDMS (polydimethylsiloxane). However, PDMS is not resistant to a variety of chemicals, has poor tolerance, and is not pressure-resistant.

[0003] In the prior art, the fluid distribution and size of the microfluidic system are large, requiring many pumps for the inlet, which is inconvenient to operate and difficult to precisely control the fluid distribution. Stimulation conditions such as heat or electromagnetic radiation cannot be built in, resulting in poor stimulation effects and low product quality.

[0004] Chinese patent document CN110339873A discloses a digital microfluidic platform, including a base plate, a lifting mechanism fixedly mounted on the base plate, a loading platform fixedly connected to the lifting mechanism, a support rod fixedly connected to the base plate, a top circuit board connected to one end of the support rod away from the base plate, a conductive needle arranged on the top circuit board and electrically connected to the top circuit board, and a digital microfluidic chip arranged on the loading platform and electrically connected to the conductive needle. The lifting mechanism drives the loading platform to rise until the digital microfluidic chip is in close contact with the conductive needle and realizes electrical connection with the conductive needle, and ensures that the conductive needle applies a certain pressure to the digital microfluidic chip. At this time, the digital microfluidic chip is located between the conductive needle and the loading platform, and is fixed between the conductive needle and the loading platform by the pressure applied by the conductive needle and the loading platform, and maintains a good compression effect, the digital microfluidic chip is not easy to loosen and will not be broken, thereby ensuring stability during the pipetting operation. The platform is used for the synthesis of biomolecular substances and is not suitable for the production of nanoparticles in industry. Summary of the invention

[0005] In view of the shortcomings of the prior art, the present invention provides a ring-shaped high-throughput microfluidic platform, which can achieve batch production and synthesis of small-scale nanoparticle materials through built-in stimulation conditions, and has a compact structure. The technical problem of multiple pumps for inlet is solved through a distribution mechanism.

[0006] The present invention also provides an application method of the annular high-throughput microfluidic platform.

[0007] The technical solution of the present invention is as follows:

[0008] A ring-shaped high-throughput microfluidic platform comprises an inlet distributor, a stimulation chamber A, a connecting distributor, a stimulation chamber B and an outlet distributor, wherein:

[0009] The inlet distributor is connected to the stimulation chamber A, the inlet distributor is connected to the connecting distributor through the stimulation chamber A, the connecting distributor is connected to the stimulation chamber B, the connecting distributor is connected to the outlet distributor through the stimulation chamber B, one end of the inner capillary is connected to the inlet distributor, and the other end passes through the stimulation chamber A to be connected to the connecting distributor, one end of the outer capillary is connected to the inner capillary on the connecting distributor, and the other end passes through the stimulation chamber B to be connected to the outlet distributor.

[0010] Preferably, the inlet distributor comprises an inlet channel A, a distribution rod A is arranged in a ring around the inlet channel A, the distribution rod A is a cavity structure with a hollow interior, and an outlet channel A is arranged on one side of the end of the distribution rod A.

[0011] Preferably, stimulation chamber A is a cylindrical structure with a hollow interior, and the internal cross-sectional shape of stimulation chamber A is a regular pentagon. A plurality of fluid channels are arranged in an inner ring of the cylinder of stimulation chamber A, and the inner diameter of the fluid channel is the same as the outer diameter of outlet channel A. The fluid channel is connected to outlet channel A, and an external connecting channel is arranged in an inner ring of the cylinder of stimulation chamber A. Stimulation chamber B has the same structure as stimulation chamber A.

[0012] Preferably, a T-shaped elastic connector is provided on the hollow structure inside the stimulation chamber A and the stimulation chamber B, and the T-shaped elastic connectors of the stimulation chamber A and the stimulation chamber B are connected by wires to further enhance the structural stability.

[0013] Further preferably, the external connection channels in the stimulation chambers A and B are filled with hot fluid, cold fluid or electromagnetic radiation to meet different product requirements.

[0014] Preferably, the connecting distributor includes an inlet channel B, a distribution rod B is arranged in a ring around the inlet channel B, the distribution rod B is a cavity structure with a hollow interior, an outlet channel B is arranged on one side of the end of the distribution rod B, the inner diameter of the outlet channel B is the same as the outer diameter of the fluid channel, the outlet channel B runs through the distribution rod B, and the outlet channel B connects the fluid channels in the stimulation chamber A and the stimulation chamber B at the same time.

[0015] Preferably, the outlet distributor comprises an inlet channel C, the inlet channel C is used for outlet, a distribution rod C is arranged in a ring around the inlet channel C, the distribution rod C is a cavity structure with a hollow interior, an outlet channel C is arranged on one side of the end of the distribution rod C, the inner diameter of the outlet channel C is the same as the outer diameter of the fluid channel, the outlet channel C does not penetrate the distribution rod C, and the outlet channel C is connected to the fluid channel of the stimulation chamber B;

[0016] The inner side of outlet channel A is connected to an inner capillary, which passes through the fluid channel in stimulation chamber A to be connected to outlet channel B. The other side of outlet channel B is connected to an outer capillary, which extends to the inside of the outer capillary, and passes through the fluid channel of stimulation chamber B to be connected to outlet channel C.

[0017] Further preferably, a chip lab is provided at the connection between the outlet channel A and the fluid channel of the stimulation chamber A, and the inner capillary runs through the chip lab. The chip lab can integrate basic operation units such as preparation, reaction, separation, and detection into a tiny flat chip, achieving high throughput and smaller space consumption.

[0018] Further preferably, a collector is installed on the outlet side of the inlet channel C, and the stimulant and fluid are supplied to other distributors through the collector.

[0019] Preferably, 6 distribution rods A, distribution rods B and distribution rods C are each provided, and two separated distribution rods A are provided with extension rods A, and extension rods A are provided with threaded holes, two separated distribution rods B are provided with extension rods B, and extension rods B are provided with threaded holes, and two separated distribution rods C are provided with extension rods C, and extension rods C are provided with threaded holes.

[0020] Further preferably, three extension rods D are provided on the outer walls of the stimulation chambers A and B, and threaded holes are provided on the extension rods D. The threaded holes on the extension rods D are consistent in relative position with the threaded holes of the distribution rods A, B and C.

[0021] Further preferably, a threaded rod is provided on the extension rod A, and the threaded rod passes through the threaded holes of the extension rod A, the extension rod D, the extension rod B, the extension rod D and the extension rod C in sequence to ensure that the relative positions of the inlet distributor, the stimulation chamber A, the connecting distributor, the stimulation chamber B and the outlet distributor are fixed.

[0022] Preferably, gaskets are provided at the connection points of the inlet distributor, the stimulation chamber A, the connecting distributor, the stimulation chamber B and the outlet distributor to ensure the sealing performance.

[0023] Preferably, the inner capillary and the outer capillary are both glass tubes. Made of glass, they have good solvent resistance and high pressure tolerance, are reusable, and are easy to install.

[0024] Preferably, the collector is a diverter tube or a vortex micromixer. The diverter tube includes a connecting pipe with a conduit arranged in a ring around the connecting pipe, which can directly divert the nanoparticles to different next-stage equipment. The vortex micromixer is used to mix the nanoparticles and then flow them to different next-stage equipment.

[0025] Preferably, a knob is provided on one side of the distribution rod A, the distribution rod B and the distribution rod C, respectively. The knob is a cone, the top of the cone is set as a platform, the bottom of the cone is set as a cylinder, and a through hole is set around the bottom surface of the cone. The inlet distributor, stimulation chamber A, connecting distributor, stimulation chamber B and outlet distributor are respectively provided with channels corresponding to the through holes. After passing through the through holes, the connecting wire passes through the inlet distributor, stimulation chamber A, connecting distributor, stimulation chamber B and outlet distributor in turn, thereby achieving the effect of further fixing the overall device.

[0026] An application method of a ring-shaped high-throughput microfluidic platform, the steps are as follows:

[0027] (1) The fluid flows into the inlet distributor, then disperses to the distribution rod A, and is distributed to the stimulation chamber A through the internal capillary in the distribution rod A;

[0028] (2) The fluid is stimulated in the stimulation chamber A, then flows into the connecting distributor, dispersed to the distribution rod B, and distributed to the stimulation chamber B through the outer capillary in the distribution rod B;

[0029] (3) The fluid flows through the stimulation chamber B through the outer capillary, produces the desired nanoparticles after being stimulated again in the stimulation chamber B, and then flows out through the outlet distributor and enters the collector.

[0030] The beneficial effects of the present invention are:

[0031] 1. The present invention realizes the production and synthesis of small-scale nanoparticle materials through built-in stimulation conditions. The existing external stimulation takes up a large space, has a low stimulation effect, and has low production efficiency.

[0032] 2. The present invention has a compact structure and realizes high-throughput production through the distribution mechanism of each distributor, avoiding the problem of the original multiple pumps used for the inlet, inconvenient operation and difficulty in precise control of fluid distribution.

[0033] 3. The inner capillary and the outer capillary of the present invention are made of glass, which has good solvent resistance and high pressure tolerance, and is reusable and easy to install.

[0034] 4. The present invention uses a multi-channel mechanism of the distributor to allow a large amount of fluid to be introduced at one time, thereby speeding up the production process and meeting the requirements of mass production. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 It is a schematic diagram of the structure of the present invention.

[0036] Figure 2 It is the front view of the import distributor structure of the present invention.

[0037] Figure 3 The left view of the inlet distributor structure of the present invention

[0038] Figure 4 The rear view of the inlet distributor structure of the present invention

[0039] Figure 5 This is a front view of the stimulation chamber A structure of the present invention.

[0040] Figure 6 It is a left view of the stimulation chamber A structure of the present invention.

[0041] Figure 7 It is a rear view of the stimulation chamber A structure of the present invention.

[0042] Figure 8 It is the front view of the connection distributor structure of the present invention.

[0043] Fig. 9 It is the left view of the connection distributor structure of the present invention.

[0044] Fig.10 It is a rear view of the connection distributor structure of the present invention.

[0045] Fig.11 It is the front view of the outlet distributor structure of the present invention.

[0046] Fig.12 It is the left view of the outlet distributor structure of the present invention.

[0047] Fig.13 It is a rear view of the outlet distributor structure of the present invention.

[0048] Fig.14 It is a schematic diagram of the shunt tube of the present invention.

[0049] Fig.15 It is the installation schematic diagram of the present invention.

[0050] Fig.16 It is the front view of the knob structure of the present invention.

[0051] Fig.17 It is the right view of the knob structure of the present invention.

[0052] Among them: 1. inlet distributor; 2. stimulation chamber A; 3. connecting distributor; 4. stimulation chamber B; 5. outlet distributor; 6. inner capillary; 7. outer capillary; 8. inlet channel A; 9. distribution rod A; 10. outlet channel A; 11. fluid channel; 12. external connection channel; 13. elastic connector; 14. inlet channel B; 15. distribution rod B; 16. outlet channel B; 17. inlet channel C; 18. distribution rod C; 19. outlet channel C; 20. shunt tube; 21. extension rod A; 22. extension rod B; 23. extension rod C; 24. extension rod D; 25. threaded hole; 26. threaded rod; 27. washer; 28. knob. DETAILED DESCRIPTION

[0053] The present invention will be further described below by way of embodiments in conjunction with the accompanying drawings, but is not limited thereto.

[0054] Embodiment 1:

[0055] A ring-shaped high-throughput microfluidic platform, the structure of which is as follows Figure 1-15 As shown, it includes an inlet distributor 1, a stimulation chamber A2, a connecting distributor 3, a stimulation chamber B4 and an outlet distributor 5, wherein:

[0056] The inlet distributor 1 is connected to the stimulation chamber A2, the inlet distributor 1 is connected to the connecting distributor 3 through the stimulation chamber A2, the connecting distributor 3 is connected to the stimulation chamber B4, the connecting distributor 3 is connected to the outlet distributor 5 through the stimulation chamber B4, one end of the inner capillary 6 is connected to the inlet distributor 1, and the other end passes through the stimulation chamber A2 to be connected to the connecting distributor 3, one end of the outer capillary 7 is connected to the inner capillary 6 on the connecting distributor 3, and the other end passes through the stimulation chamber B4 to be connected to the outlet distributor 5, the outlet distributor 5 is connected to the collector, the collector is a shunt tube 20, the shunt tube includes a connecting pipe, and a conduit is arranged in a ring around the connecting pipe, which can directly divert the nanoparticles to different next-level devices.

[0057] The inlet distributor 1 comprises an inlet channel A8, around which a distribution rod A9 is arranged in a ring shape. The distribution rod A9 is a cavity structure with a hollow interior. An outlet channel A10 is arranged at one end of the distribution rod A9, and the outlet channel A10 does not penetrate the distribution rod A9.

[0058] The stimulation chamber A2 is a cylindrical structure with a hollow interior. The internal cross-sectional shape of the stimulation chamber A2 is a regular pentagon. A plurality of fluid channels 11 are arranged in an inner ring of the cylinder of the stimulation chamber A2. The inner diameter of the fluid channel 11 is the same as the outer diameter of the outlet channel A10. The fluid channel is connected to the outlet channel A. An external connecting channel 12 is arranged in an inner ring of the cylinder of the stimulation chamber A2. The external connecting channel 12 is filled with hot fluid. The stimulation chamber B4 has the same structure as the stimulation chamber A2.

[0059] The connecting distributor 3 includes an inlet channel B14, around which a distribution rod B15 is arranged in a ring. The distribution rod B15 is a cavity structure with a hollow interior. An outlet channel B16 is arranged on one side of the end of the distribution rod B15. The inner diameter of the outlet channel B16 is the same as the outer diameter of the fluid channel 11. The outlet channel B16 runs through the distribution rod B15. The outlet channel B16 connects the fluid channels in the stimulation chamber A and the stimulation chamber B at the same time.

[0060] The outlet distributor 5 includes an inlet channel C17, which is used for outlet. A distribution rod C18 is arranged in a ring around the inlet channel C17. The distribution rod C18 is a cavity structure with a hollow interior. An outlet channel C19 is arranged at one end of the distribution rod C18. The inner diameter of the outlet channel C19 is the same as the outer diameter of the fluid channel 11. The outlet channel C19 does not penetrate the distribution rod C18. The outlet channel C19 is connected to the fluid channel 11 of the stimulation chamber B4.

[0061] like Fig.15 As shown, the inner side of the outlet channel A10 is connected to the inner capillary 6, the inner capillary 6 passes through the fluid channel 11 in the stimulation chamber A2 to be connected to the outlet channel B16, the other side of the outlet channel B16 is connected to the outer capillary 7, the inner capillary 6 extends to the inside of the outer capillary 7, the outer capillary 7 passes through the fluid channel 11 of the stimulation chamber B4 to be connected to the outlet channel C19.

[0062] A chip lab is provided at the connection between the outlet channel A10 and the fluid channel of the stimulation chamber A2, and the inner capillary 6 runs through the chip lab. The chip lab can integrate the basic operation units such as preparation, reaction, separation, and detection into a tiny flat chip, and various functional tests can be performed in the device to achieve high throughput and smaller space consumption.

[0063] A collector is installed on the outlet side of the inlet channel C17, through which stimulants and fluids are supplied to other distributors.

[0064] The application method of the annular high-throughput microfluidic platform comprises the following steps:

[0065] (1) The fluid flows into the inlet distributor 1, and then disperses to the distribution rod A9, and is distributed to the stimulation chamber A2 through the inner capillary 6 in the distribution rod A9;

[0066] (2) The fluid is stimulated in the stimulation chamber A2, then flows into the connecting distributor 3, dispersed to the distribution rod B15, and distributed to the stimulation chamber B4 through the outer capillary 7 in the distribution rod B15;

[0067] (3) The fluid flows through the stimulation chamber B4 through the outer capillary 7, produces the desired nanoparticles after being stimulated again in the stimulation chamber B4, and then flows out through the outlet distributor 5 and enters the collector.

[0068] Embodiment 2:

[0069] A ring-shaped high-throughput microfluidic platform has a structure as described in Example 1, except that a T-shaped elastic connector 13 is provided on the hollow structure inside the stimulation chamber A2 and the stimulation chamber B4, and the T-shaped elastic connector 13 of the stimulation chamber A2 and the stimulation chamber B4 is connected by wire to further enhance the structural stability.

[0070] Embodiment 3:

[0071] An annular high-throughput microfluidic platform, as described in Example 2, except that the external connecting channels 12 in the stimulation chambers A2 and B4 are filled with cold fluid.

[0072] Embodiment 4:

[0073] A ring-shaped high-throughput microfluidic platform, as described in Example 2, except that the external connecting channels 12 in the stimulation chambers A2 and B4 are filled with cold fluid and electromagnetic radiation.

[0074] Embodiment 5:

[0075] A ring-shaped high-throughput microfluidic platform has a structure as described in Example 1, except that six distribution rods A9, six distribution rods B15 and six distribution rods C18 are provided, two separated distribution rods A9 are provided with extension rods A21, and threaded holes 25 are provided on the extension rod A21, two separated distribution rods B15 are provided with extension rods B22, and threaded holes are provided on the extension rod B22, two separated distribution rods C18 are provided with extension rods C23, and threaded holes are provided on the extension rod C23, three extension rods D24 are provided on the outer walls of stimulation chambers A2 and B4, and threaded holes 25 are provided on the extension rod D24, and the threaded holes on the extension rod D24 are consistent in relative position with the threaded holes of the distribution rods A9, the distribution rods B15 and the distribution rod C18.

[0076] A threaded rod 26 is provided on the extension rod A21, and the threaded rod 26 passes through the threaded holes of the extension rod A21, the extension rod D24, the extension rod B22, the extension rod D24 and the extension rod C23 in sequence to ensure that the relative positions of the inlet distributor, the stimulation chamber A, the connecting distributor, the stimulation chamber B and the outlet distributor are fixed.

[0077] Embodiment 6:

[0078] A ring-shaped high-throughput microfluidic platform has a structure as described in Example 1, except that a gasket 27 is installed at the connection between the inlet distributor 1, the stimulation chamber A2, the connecting distributor 3, the stimulation chamber B4 and the outlet distributor 5, and the sealing is ensured by the gasket 27.

[0079] Embodiment 7:

[0080] A ring-shaped high-throughput microfluidic platform, as described in Example 1, the difference is that the inner capillary 6 and the outer capillary 7 are both glass tubes, which are made of glass and have good solvent resistance and high pressure tolerance. They are reusable and easy to install.

[0081] Embodiment 8:

[0082] A ring-shaped high-throughput microfluidic platform, as described in Example 1, except that the collector is a vortex micromixer, which is used to mix the nanoparticles and then flow them to different next-level devices.

[0083] Embodiment 9:

[0084] A ring-shaped high-throughput microfluidic platform, as described in Example 1, except that a knob 28 is provided on one side of the distribution rod A9, the distribution rod B15 and the distribution rod C18, and the structure of the knob 28 is as follows: Figure 16-17 As shown, the knob 28 is a cone, the top of the cone is set as a platform, the bottom of the cone is set as a cylinder, and a through hole is set around the bottom surface of the cone. The inlet distributor 1, the stimulation chamber A2, the connecting distributor 3, the stimulation chamber B4 and the outlet distributor 5 are respectively provided with channels corresponding to the through holes. After passing through the through holes, the connecting wire passes through the inlet distributor 1, the stimulation chamber A2, the connecting distributor 3, the stimulation chamber B4 and the outlet distributor 5 in turn, so as to achieve the effect of further fixing the overall device.

Claims

1. A ring-shaped high-throughput microfluidic platform, characterized in that: It includes an inlet distributor, a stimulation chamber A, a connecting distributor, a stimulation chamber B and an outlet distributor, wherein: The inlet distributor is connected to the stimulation chamber A, the inlet distributor is connected to the connection distributor through the stimulation chamber A, the connection distributor is connected to the stimulation chamber B, the connection distributor is connected to the outlet distributor through the stimulation chamber B, one end of the inner capillary is connected to the inlet distributor, and the other end passes through the stimulation chamber A to connect to the connection distributor, one end of the outer capillary is connected to the inner capillary on the connection distributor, and the other end passes through the stimulation chamber B to connect to the outlet distributor, and the outlet distributor is connected to the collector; The inlet distributor comprises an inlet channel A, a distribution rod A is arranged in a ring around the inlet channel A, the distribution rod A is a cavity structure with a hollow interior, and an outlet channel A is arranged at one side of the end of the distribution rod A; The stimulation chamber A is a cylindrical structure with a hollow interior, and the internal cross-sectional shape of the stimulation chamber A is a regular pentagon. A plurality of fluid channels are arranged in the cylindrical ring of the stimulation chamber A, and the inner diameter of the fluid channel is the same as the outer diameter of the outlet channel A. The fluid channel is connected to the outlet channel A. An external connecting channel is arranged in the cylindrical ring of the stimulation chamber A. The stimulation chamber B has the same structure as the stimulation chamber A. The connecting distributor comprises an inlet channel B, a distribution rod B is arranged in a ring around the inlet channel B, the distribution rod B is a cavity structure with a hollow interior, an outlet channel B is arranged on the other side of the end of the distribution rod B, the inner diameter of the outlet channel B is the same as the outer diameter of the fluid channel, the outlet channel B runs through the distribution rod B, and the outlet channel B is connected to the fluid channels in the stimulation chamber A and the stimulation chamber B at the same time; The outlet distributor includes an inlet channel C, which is used for outlet. A distribution rod C is arranged in a ring around the inlet channel C. The distribution rod C is a cavity structure with a hollow interior. An outlet channel C is arranged on the other side of the end of the distribution rod C. The inner diameter of the outlet channel C is the same as the outer diameter of the fluid channel. The outlet channel C does not penetrate the distribution rod C. The outlet channel C is connected to the fluid channel of the stimulation chamber B. The inner side of the outlet channel A is connected to an inner capillary tube, which passes through the fluid channel in the stimulation chamber A and is connected to the outlet channel B. The other side of the outlet channel B is connected to an outer capillary tube, which extends to the inside of the outer capillary tube, and the outer capillary tube passes through the fluid channel of the stimulation chamber B and is connected to the outlet channel C. A collector is installed on the outlet side of the inlet channel C, and stimulants and fluids are supplied to other distributors through the collector. A chip lab is provided at the connection between the outlet channel A and the fluid channel of the stimulation chamber A, and an inner capillary runs through the chip lab; A T-shaped elastic connector is provided on the hollow structure inside the stimulation chamber A and the stimulation chamber B, and the external connection channels inside the stimulation chamber A and the stimulation chamber B are filled with hot fluid, cold fluid or electromagnetic radiation.

2. The annular high-throughput microfluidic platform according to claim 1, characterized in that: Six distribution rods A, distribution rods B and distribution rods C are provided respectively, and two distribution rods A are provided with extension rods A, and extension rods A are provided with threaded holes, two distribution rods B are provided with extension rods B, and extension rods B are provided with threaded holes, and two distribution rods C are provided with extension rods C, and extension rods C are provided with threaded holes; Three extension rods D are arranged on the outer walls of the stimulation chambers A and B, and threaded holes are arranged on the extension rods D. The threaded holes on the extension rods D are in the same relative position as the threaded holes on the distribution rods A, B and C. The extension rod A is provided with a threaded rod, which passes through the threaded holes of the extension rod A, the extension rod D, the extension rod B, the extension rod D and the extension rod C in sequence to ensure that the relative positions of the inlet distributor, the stimulation chamber A, the connecting distributor, the stimulation chamber B and the outlet distributor are fixed; The collector is a shunt pipe or a vortex micro-mixer. The shunt pipe includes a connecting pipe. A conduit is arranged in a ring around the connecting pipe to directly shunt the nanoparticles to different next-stage equipment. The vortex micro-mixer is used to mix the nanoparticles and then flow them to different next-stage equipment. A knob is respectively provided on one side of the distribution rod A, the distribution rod B and the distribution rod C. The knob is a cone, the top of the cone is set as a platform, the bottom of the cone is set as a cylinder, and a through hole is set around the bottom surface of the cone. The inlet distributor, stimulation chamber A, the connecting distributor, the stimulation chamber B and the outlet distributor are respectively provided with channels corresponding to the through holes. After passing through the through holes, the connecting line passes through the inlet distributor, the stimulation chamber A, the connecting distributor, the stimulation chamber B and the outlet distributor in turn, so as to achieve the effect of further fixing the overall device.

3. The annular high-throughput microfluidic platform according to claim 2, characterized in that: Gaskets are provided at the connections of the inlet distributor, the stimulation chamber A, the connecting distributor, the stimulation chamber B and the outlet distributor.

4. The annular high-throughput microfluidic platform according to claim 1, characterized in that: The inner capillary and the outer capillary are both glass tubes.

5. An application method of the annular high-throughput microfluidic platform according to any one of claims 1 to 4, characterized in that: Here are the steps: (1) The fluid flows into the inlet distributor, then disperses to the distribution rod A, and is distributed to the stimulation chamber A through the internal capillary in the distribution rod A; (2) The fluid is stimulated in the stimulation chamber A, then flows into the connecting distributor, dispersed to the distribution rod B, and distributed to the stimulation chamber B through the outer capillary in the distribution rod B; (3) The fluid flows through the stimulation chamber B through the outer capillary, produces the desired nanoparticles after being stimulated again in the stimulation chamber B, and then flows out through the outlet distributor and enters the collector.

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