Internal clamp arm control mechanism, mitral valve repair device and control handle thereof

Abstract

The present application discloses an inner clamp arm control mechanism, a mitral valve repair device and a control handle thereof. The inner clamp arm control mechanism comprises a housing, a second control part and a connecting rod; a second slide groove is provided on the housing, and the second control part passes through the second slide groove and is fixedly connected to the outer wall of the connecting rod; the second control part can move along the second slide groove to drive the connecting rod to move, and the movement of the connecting rod can control the movement of the inner clamp arm of the tissue clamping device.

Description

Technical Field

[0001] The present application relates to the field of medical equipment, and in particular to an inner clamp arm control mechanism, a mitral valve repair device and a control handle thereof. Background Art

[0002] A valve is a membrane-like structure that can be opened and closed inside the organs of humans or certain animals. For example, each person has four valves in their heart, namely the aortic valve, pulmonary valve, mitral valve, and tricuspid valve. Taking the mitral valve as an example, the mitral valve is located between the left atrium and the left ventricle. When the left ventricle contracts, the mitral valve acts as a check valve to tightly close the atrioventricular orifice to prevent blood from flowing back from the left ventricle into the left atrium. However, when the mitral valve is diseased, it may be difficult to close completely when the left ventricle contracts, causing the left atrium to receive a large amount of reflux blood, which may cause a sharp increase in left atrium and pulmonary venous pressure, increase the left ventricular diastolic volume load, and further lead to a series of pathological changes such as left ventricular enlargement and pulmonary hypertension, ultimately leading to clinical manifestations such as heart failure and arrhythmia, which can be life-threatening in severe cases. When repairing a diseased mitral valve, the opposite sides of the mitral valve can be clamped by the mitral valve repair device, so that the hole between the mitral valves is changed from a large hole to two small holes, reducing the regurgitation area, thereby effectively preventing the occurrence of mitral valve regurgitation. Similarly, the mitral valve repair device can also be used to repair other valves such as the tricuspid valve of the heart, and the effect of reducing the regurgitation area is achieved by clamping the leaflets on both sides. The mitral valve repair device includes a control handle, which can be used to manipulate the tissue clamping device to repair the valve. The mitral valve repair device includes a tissue clamping device, and during the valve repair process, the inner clamping arm in the tissue clamping device needs to be controlled. Summary of the invention

[0003] One of the embodiments of the present application provides an inner clamp arm control mechanism, which is characterized in that it includes a shell, a second control part and a connecting rod; a second slide groove is opened on the shell, and the second control part passes through the second slide groove and is fixedly connected to the outer wall of the connecting rod; the second control part can move along the second slide groove to drive the connecting rod to move, and the movement of the connecting rod can control the movement of the inner clamp arm of the tissue clamping device.

[0004] In some embodiments, the connecting rod controls the movement of the inner clamp arm through a traction rope; the connecting rod includes an inner hole, the traction rope passes through the inner hole of the connecting rod, and both ends of the traction rope are detachably connected to the rear end of the connecting rod.

[0005] In some embodiments, the second control unit includes a first sub-control unit for controlling the first inner clamp arm and a second sub-control unit for controlling the second inner clamp arm; the second slide groove includes a first sub-slide groove and a second sub-slide groove corresponding to the first sub-control unit and the second sub-control unit respectively.

[0006] In some embodiments, the second control portion includes a control button and a connector, the control button passes through the second slide slot and is connected to the connector, and the connector is fixedly connected to an outer wall of the connecting rod.

[0007] In some embodiments, the control button is movably connected to the connecting body through a spring; a groove is provided on the shell, and a protrusion is provided on the button, and the protrusion can be engaged with the groove under the action of the spring to limit the movement of the second control part relative to the second slide groove.

[0008] In some embodiments, at least two grooves are provided on the shell, and when the protrusions are respectively engaged with the two grooves, the second control portion is located at two ends of the second slide groove.

[0009] An embodiment of the present application provides a mitral valve repair control handle, comprising the inner clamp arm control mechanism described in any embodiment of the present application.

[0010] In some embodiments, the mitral valve repair control handle also includes an outer clamp arm control mechanism for controlling the movement of the outer clamp arm of the tissue clamping device; the outer clamp arm control mechanism includes a sleeve, a first control part, a sliding part and a driving rod, the sliding part is arranged in the sleeve, and the sliding part is connected to the driving rod; the first control part can drive the sliding part to move in the sleeve along the length direction of the sleeve by rotation, and then drive the driving rod to move to control the opening and closing of the outer clamp arm; wherein, an internal thread is provided on the inner circumferential surface of the first control part; an external thread is provided on the sliding part; the sleeve is provided with a first sliding groove along the length direction; the sliding part passes through the first sliding groove and the external thread on the sliding part cooperates with the internal thread of the first control part.

[0011] In some embodiments, the mitral valve repair control handle also includes a guide block; the guide block includes three spaced-apart through holes A, B and C, and the central axes of the three through holes are located on a first plane, wherein the through holes A and C on both sides are used to guide the connecting rod that controls the movement of the inner clamp arm, and the middle through hole B is used to guide the driving rod that controls the movement of the outer clamp arm; on one side of the first plane, the through hole A and the through hole B are interconnected by a hose, and on the other side of the first plane, the through hole B and the through hole C are interconnected by a hose.

[0012] An embodiment of the present application provides a mitral valve repair device, including the mitral valve repair control handle described in any embodiment of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] The present application will be further described in the form of exemplary embodiments, which will be described in detail by way of the accompanying drawings. These embodiments are not restrictive, and in these embodiments, the same number represents the same structure, wherein:

[0014] Figure 1 is a schematic diagram of the structure of a mitral valve repair device according to some embodiments of the present application;

[0015] Figure 2 is a schematic diagram of the structure of a tissue clamping device and a delivery connector according to some embodiments of the present application;

[0016] Figure 3 is a schematic structural diagram of an outer clamping arm of a tissue clamping device in an open state according to some embodiments of the present application;

[0017] Figure 4 is a schematic diagram of the structure of a conveying connection according to some embodiments of the present application;

[0018] Figure 5 is a structural schematic diagram of a tissue clamping device in a closed state according to another embodiment of the present application;

[0019] Figure 6 is a structural schematic diagram of a tissue clamping device in an open state according to another embodiment of the present application;

[0020] Figure 7 is a schematic structural diagram of an inner clamp arm control mechanism according to some embodiments of the present application;

[0021] Figure 8 is a partial structural schematic diagram of an inner clamp arm control mechanism according to some embodiments of the present application;

[0022] Fig. 9 is a schematic diagram of the structure of a second control unit according to some embodiments of the present application;

[0023] Fig.10 is a partial cross-sectional structural schematic diagram of an inner clamp arm control mechanism according to some embodiments of the present application;

[0024] Fig.11 is a schematic structural diagram of an outer clamp arm control mechanism according to some embodiments of the present application;

[0025] Fig.12 is a partial structural schematic diagram of an outer clamp arm control mechanism according to some embodiments of the present application;

[0026] Fig.13 is a schematic structural diagram of a sliding portion according to some embodiments of the present application;

[0027] Fig.14is a schematic diagram of an exploded structure of a control handle according to some embodiments of the present application;

[0028] Fig.15 It is a schematic diagram of the structure of a guide block according to some embodiments of the present application.

[0029] In the figure: 100-mitral valve repair device; 200-tissue clamping device; 210-inner clamp arm; 211-first inner clamp arm; 213-second inner clamp arm; 215-barb; 220-outer clamp arm; 221-first outer clamp arm; 223-second outer clamp arm; 230-fixing member; 240-supporting part; 250-connecting member; 260-outer clamp plate; 261-first outer clamp plate; 263-second outer clamp plate; 270-connecting tube; 280-elastic locking member; 300-control handle; 400-outer clamp arm control mechanism; 410-sleeve; 412-first slide groove; 420-first control part; 430-sliding part; 440-driving rod; 460-fixing block; 470-protective cover; 500-inner clamp arm control mechanism; 51 0-housing; 511-second slide groove; 511-1-first sub-slide groove; 511-2-second sub-slide groove; 520-second control unit; 520-1-first sub-control unit; 520-2-second sub-control unit; 521-connecting rod; 521-1-first sub-connecting rod; 521-2-second sub-connecting rod; 523-end cover; 523-1-first sub-end cover; 523-2-second sub-end cover; 533-control button; 535-bump; 537-connecting body; 539-groove; 540-guide block; 541-first through hole; 542-second through hole; 600-delivery pipe; 700-delivery connector; 710-main body; 720-first connecting plate; 730-second connecting plate; 740-fixed support rod. DETAILED DESCRIPTION

[0030] In order to make the purpose, technical solution and advantages of the present application more clearly understood, the present application is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and are not used to limit the present application.

[0031] On the contrary, the present application covers any substitution, modification, equivalent method and scheme made on the essence and scope of the present application as defined by the claims. Further, in order to make the public have a better understanding of the present application, some specific details are described in detail in the detailed description of the present application below. Those skilled in the art can fully understand the present application without the description of these details.

[0032] Embodiments of the present application relate to a mitral valve repair device and a control handle thereof. The mitral valve repair device can be used to repair the mitral valve or other valves (such as the tricuspid valve). The mitral valve repair device may include a tissue clamping device and a control handle. The tissue clamping device may be used to clamp the valve to repair the valve. The control handle may be used to transport and manipulate the tissue clamping device. In some embodiments, the tissue clamping device may reach a predetermined position through a variety of paths. For example, the tissue clamping device may be transported to the mitral valve via the femoral vein, the inferior vena cava, the right atrium, and the left atrium to repair the mitral valve. For another example, the tissue clamping device may be transported to the mitral valve via the left atrial appendage and the left atrium to repair the mitral valve.

[0033] Figure 1 is a schematic diagram of the structure of a mitral valve repair device according to some embodiments of the present application; Figure 2 is a schematic diagram of the structure of a tissue clamping device and a delivery connector according to some embodiments of the present application; Figure 3 is a schematic structural diagram of an outer clamping arm of a tissue clamping device in an open state according to some embodiments of the present application; Figure 4 Schematic diagram of the structure of the delivery connector according to some embodiments of the present application. Figure 1-4 As shown, the mitral valve repair device 100 may include a tissue clamping device 200 and a control handle 300. The tissue clamping device 200 may include an outer clamping arm 220 and an inner clamping arm 210; the control handle 300 may correspondingly include an outer clamping arm control mechanism 400 and an inner clamping arm control mechanism 500. The outer clamping arm control mechanism 400 can be used to control the opening and closing of the outer clamping arm 220 of the tissue clamping device 200, and the inner clamping arm control mechanism 500 can be used to control the opening and closing of the inner clamping arm 210 relative to the outer clamping arm 220, so that the control handle 300 can control the opening and closing of the outer clamping arm 220 and the inner clamping arm 210 so that the valve (such as the mitral valve) can be clamped between the outer clamping arm 220 and the inner clamping arm 210.

[0034] In some embodiments, the mitral valve repair device 100 may include a delivery tube 600; the tissue clamping device 200 is connected to the control handle 300 through the delivery tube 600. In some embodiments, the delivery tube 600 can be bent (for example, the delivery tube 600 is made of an elastic material); the control handle 300 can deliver the tissue clamping device 200 to the mitral valve via the femoral vein, the inferior vena cava, the right atrium or the left atrium through the bendable delivery tube 600. In some embodiments, the delivery tube 600 is not bendable (for example, the delivery tube 600 is made of a rigid material), in which case the control handle 300 can deliver the tissue clamping device 200 to the mitral valve via the left atrial appendage or the left atrium through the inflexible delivery tube 600. By delivering the tissue clamping device 200 to the mitral valve via the left atrial appendage and the left atrium, the operation of the mitral valve repair can be made more convenient, and the efficiency and success rate of the repair can be higher. In addition, when the delivery tube 600 is not bendable, the mitral valve repair device 100 can also be used for other purposes. For example, the mitral valve repair device 100 can be used to perform valve repair experiments on animals (such as pigs).

[0035] In some embodiments, Figure 2-4 As shown, the tissue clamping device 200 may include an inner clamp arm 210, an outer clamp arm 220, a fixing member 230, a support portion 240, a connecting member 250 and an outer clamp plate 260. The inner clamp arm 210 may include a first inner clamp arm 211 and a second inner clamp arm 213; the outer clamp arm 220 may include a first outer clamp arm 221 and a second outer clamp arm 223; and the outer clamp plate 260 may include a first outer clamp plate 261 and a second outer clamp plate 263. One side of the support portion 240 is bendably connected to the first outer clamp arm 221 and the first outer clamp plate 261 in sequence, and the other side of the support portion 240 is bendably connected to the second outer clamp arm 223 and the second outer clamp plate 263 in sequence. The first outer clamp arm 221 and the second outer clamp arm 223 can be bent relative to the support portion 240 and relatively closed, and the first outer clamp arm 221 and the second outer clamp arm 223 can also be bent away from the support portion 240 and relatively open. Figure 2 The tissue clamping device 200 is shown in a state where the first outer clamping arm 221 and the second outer clamping arm 223 are relatively closed; Figure 3 The tissue clamping device 200 shown is in a state where the first outer clamping arm 221 and the second outer clamping arm 223 are relatively opened to 180 degrees. The angle at which the first outer clamping arm 221 and the second outer clamping arm 223 are relatively opened can be any angle, such as 10°, 40°, 90°, 120°, 180°, 270°, 350°, 360°, etc. In some embodiments, the outer clamping arm 220, the support portion 240 and the outer clamping plate 260 can be an integrally formed structure. For example, the outer clamping arm 220, the support portion 240 and the outer clamping plate 260 can be an integrally formed structure made of shape memory alloy pipes through cutting and heat treatment. In some embodiments, as Figure 2As shown, one end of the support portion 240 (the upper end shown in the figure) is connected to (such as fixedly connected to) the connecting member 250, and one end of the first outer clamping plate 261 (the lower end shown in the figure) and one end of the second outer clamping plate 263 (the lower end shown in the figure) are respectively connected to (such as fixedly connected to) the fixing member 230. With such an arrangement, when the fixing member 230 moves relative to the connecting member 250, the fixing member 230 can move relative to the support portion 240. When the fixing member 230 is away from the support portion 240, driven by the fixing member 230, the first outer clamping plate 261 and the second outer clamping plate 263 can respectively pull the first outer clamping arm 221 and the second outer clamping arm 223 to open relative to each other. Figure 2-4 In the embodiment shown, the outer clamp arm control mechanism 400 can control the opening and closing of the outer clamp arm 220 of the tissue clamping device 200 through the driving rod 440. Specifically, one end of the driving rod 440 (eg Figure 2 The lower end of the outer clamp arm 220 of the tissue clamping device 200 can have a threaded structure, through which the driving rod 440 can be detachably connected to the fixing member 230. The outer clamp arm control mechanism 400 can control the fixing member 230 to move relative to the connecting member 250 by pushing and pulling the driving rod 440 (such as driving the driving rod 440 to move through the sliding portion 430), thereby controlling the opening and closing of the outer clamp arm 220 of the tissue clamping device 200.

[0036] In some embodiments, the first inner clamp arm 211 can be arranged on the first outer clamp arm 221, and the second inner clamp arm 213 can be arranged on the second outer clamp arm 223. The first inner clamp arm 211 and the second inner clamp arm 213 can be opened and closed relative to the first outer clamp arm 221 and the second outer clamp arm 223, respectively, and the tissue can be clamped between the first inner clamp arm 211 and the first outer clamp arm 221 and between the second inner clamp arm 213 and the second outer clamp arm 223. In some embodiments, the inner clamp arm 210 can be a barbed clamp. For example, a barb 215 can be installed at the movable end of the inner clamp arm 210. In some embodiments, the inner clamp arm 210 and the outer clamp arm 220 can be connected by a bending portion (such as an S-bar bending structure), and the bending portion can have a prefabricated resilience, so that the inner clamp arm 210 can be close to the outer clamp arm 220 in a natural state. In some embodiments, the inner clamp arm control mechanism 500 can control the opening and closing of the inner clamp arm 210 relative to the outer clamp arm 220 through a traction rope (not shown in the figure). For example, the traction rope can be connected to the movable end of the inner clamp arm 210. When the inner clamp arm control mechanism 500 pulls the traction rope, the inner clamp arm 210 can be opened relative to the outer clamp arm 220 under the tension of the traction rope; when the traction rope is relaxed, the inner clamp arm 210 can be closed with the outer clamp arm 220 under the prefabricated resilience of the bending portion. In some embodiments, the traction rope can include steel wire, nanowire or glass rope, etc., which is not limited in the present application.

[0037] In some embodiments, the delivery tube 600 can be detachably connected to the tissue clamping device 200 via a delivery connector 700. The delivery connector 700 is provided with through holes for the driving rod 440 and the traction rope to pass through respectively. Figure 2 and Figure 4 In the illustrated embodiment, the transport connector 700 may include a main body 710, a first connector 720 and a second connector 730. The connection between the first connector 720 and the second connector 730 and the main body 710 may have a prefabricated resilience, which enables the first connector 720 and the second connector 730 to automatically open in a natural state. A fixed support rod 740 may also be provided in the middle of the first connector 720 and the second connector 730, and the fixed support rod 740 is respectively perpendicular to the first connector 720 and the second connector 730, and a through hole for the driving rod 440 to pass through is provided at one end of the fixed support rod 740 that is suspended. When the transport connector 700 is connected to the connector 250 of the tissue clamping device, the first connector 720 and the second connector 730 are relatively closed and are respectively engaged with the protrusions on the connector 250. At this time, the driving rod 440 can pass through the through hole on the fixed support rod 740 connected to the first connecting piece 720 and the second connecting piece 730, and the driving rod 440 will limit the first connecting piece 720 and the second connecting piece 730 from opening. When it is necessary to disengage the transport connector 700 from the tissue clamping device 200, the connection between the driving rod 440 and the tissue clamping device 200 (such as the fixing piece 230) can be released first and the driving rod 440 can be withdrawn, so that the driving rod 440 is disengaged from the through hole on the fixed support rod 740 connected to the first connecting piece 720 and the second connecting piece 730, so that the first connecting piece 720 and the second connecting piece 730 are automatically opened and disengaged from the clamping connection with the protrusion on the connector 250. In some embodiments, the transport connector 700 can be an integrally formed structure made of a shape memory alloy tube after cutting and heat treatment.

[0038] In some embodiments, the tissue clamping device 200 may also be in other alternative structural forms. For example, Figure 5 is a structural schematic diagram of a tissue clamping device in a closed state according to another embodiment of the present application; Figure 6 1 is a schematic structural diagram of a tissue clamping device in an open state according to another embodiment of the present application. Figure 5-6In the illustrated embodiment, the tissue clamping device 200 may include a fixing member 230, an inner clamp arm 210, and an outer clamp arm 220. The inner clamp arm 210 may include a first inner clamp arm 211 and a second inner clamp arm 213, the inner clamp arm 210 is disposed on the fixing member 230, and the first inner clamp arm 211 and the second inner clamp arm 213 can be closed or opened with each other. The outer clamp arm 220 may include a first outer clamp arm 221 and a second outer clamp arm 223, the first outer clamp arm 221 and the second outer clamp arm 223 are both disposed on the fixing member 230, the first outer clamp arm 221 and the second outer clamp arm 223 can be relatively closed or opened, and a valve (such as a mitral valve) can be clamped between the first inner clamp arm 211 and the first outer clamp arm 221 and between the second inner clamp arm 213 and the second outer clamp arm 223.

[0039] exist Figure 5-6 In the illustrated embodiment, the tissue clamping device 200 may further include a connecting tube 270 and an elastic locking member 280. The delivery tube 600 may be detachably connected to the connecting tube 270 (e.g., threaded connection). The driving rod 440 may be directly or indirectly connected to the fixing member 230. The outer clamping arm 220 may be rotatably connected to the fixing member 230 and the connecting tube 270 through a connecting rod structure. The outer clamping arm control mechanism 400 may control the fixing member 230 to move relative to the connecting tube 270 by pushing and pulling the driving rod 440, thereby controlling the opening and closing of the outer clamping arm 220 of the tissue clamping device 200. When the outer clamping arm 220 is opened and closed to a certain angle (e.g., 10°, 90°, 150°, 180°, etc.) or closed, the elastic locking member disposed on the fixing member 230 may cooperate with the bayonet on the connecting tube 270, thereby forming a certain resistance to the opening and closing of the outer clamping arm 220. In some embodiments, the inner clamp arm 210 may be an integrally formed U-shaped structure and have a prefabricated resilience to open outward. The inner clamp arm control mechanism 500 may control the inner clamp arm 210 to open and close relative to the outer clamp arm 220 through a traction rope (not shown in the figure). For example, the traction rope may be connected to the movable end of the inner clamp arm 210. When the inner clamp arm control mechanism 500 pulls the traction rope, the inner clamp arm 210 may open relative to the outer clamp arm 220 under the tension of the traction rope (that is, the first inner clamp arm 211 and the second inner clamp arm 213 are closed together); when the traction rope is relaxed, the inner clamp arm 210 may open outward under the action of its prefabricated resilience and thus close relative to the outer clamp arm 220. Specifically, the first inner clamp arm 211 and the first outer clamp arm 221 may be controlled separately to open or close relative to the first outer clamp arm 221 and the second outer clamp arm 223, respectively.

[0040] The following will be Figure 2-4 The control handle 300 is described by taking the tissue clamping device 200 shown in the figure as an example. It should be noted that the control handle described in the following embodiments is only for illustrative purposes and does not constitute a limitation thereto. Part or all of the structure of the control handle 300 can be applied not only to Figure 2-4 The tissue clamping device 200 shown can also be applied to other types of tissue clamping devices (e.g., Figure 5-6 Tissue clamping device shown).

[0041] In some embodiments, the control handle 300 includes an outer clamp arm control mechanism 400 and an inner clamp arm control mechanism 500. The outer clamp arm control mechanism 400 is used to control the movement of the outer clamp arm 220 of the tissue clamping device 200; the inner clamp arm control mechanism 500 is used to control the movement of the inner clamp arm 210 of the tissue clamping device 200.

[0042] Figure 7 is a schematic structural diagram of an inner clamp arm control mechanism according to some embodiments of the present application; Figure 8 is a partial structural schematic diagram of an inner clamp arm control mechanism according to some embodiments of the present application; Fig. 9 is a schematic diagram of the structure of a second control unit according to some embodiments of the present application; Fig.10 is a partial cross-sectional structural diagram of an inner clamp arm control mechanism according to some embodiments of the present application. Figure 7-10 As shown, the inner clamp arm control mechanism 500 may include a housing 510, a second control portion 520 and a connecting rod 521; wherein the housing 510 is provided with a second slide groove 511, and the second control portion 520 may pass through the second slide groove 511 and be fixedly connected to the outer wall of the connecting rod 521. The second control portion 520 may move along the second slide groove 511 to drive the connecting rod 521 to move, and the movement of the connecting rod 521 may control the movement of the inner clamp arm 210 of the tissue clamping device 200.

[0043] In some embodiments, the connecting rod 521 can control the movement of the inner clamp arm 210 through a traction cable. In a specific embodiment, the connecting rod 521 may include an inner hole, and the traction cable can pass through the inner hole of the connecting rod 521. The traction cable can pass through the through hole of the movable end of the inner clamp arm 210, and the two ends of the traction cable can be detachably connected to the rear end (the end away from the tissue clamping device 200) of the connecting rod 521. Specifically, the rear end of the connecting rod 521 can be provided with an end cap 523, and the two ends of the traction cable can be fixed at the end cap 523. For example, the end cap 523 can be connected to the connecting rod 521 by a thread, and the two ends of the traction cable can be clamped at the threaded connection between the end cap 523 and the connecting rod 521. When it is necessary to separate the tissue clamping device 200 from the control handle 300, the end cap 523 can be separated from the connecting rod 521, and the two ends of the traction cable can be released and the traction cable can be pulled out, so that the control handle 300 can be separated from the inner clamp arm 210. In some embodiments, releasing the fixation of the two ends of the traction rope may include: releasing the clamping connection between the two ends of the traction rope and the end caps, untying the knot formed by the two ends of the traction rope, cutting the traction rope, etc. In some embodiments, the traction rope may not be completely pulled out of the control handle 300, but the traction rope may be separated from the inner clamp arm 210. The arrangement of the connecting rod 521 and the end cap 523 can facilitate the pulling out of the traction rope, and at the same time, the inner clamp arm control mechanism 500 can be easily manufactured.

[0044] In some embodiments, the second control unit 520 may include a first sub-control unit 520-1 for controlling the first inner clamping arm 211 and a second sub-control unit 520-2 for controlling the second inner clamping arm 213. The second slide groove 511 may include a first sub-slide groove 511-1 and a second sub-slide groove 511-2 corresponding to the first sub-control unit 520-1 and the second sub-control unit 520-2, respectively. The connecting rod 521 may include a first sub-connecting rod 521-1 and a second sub-connecting rod 521-2 respectively connected to the first sub-control unit 520-1 and the second sub-control unit 520-2, and the rear ends of the first sub-connecting rod 521-1 and the second sub-connecting rod 521-2 may be provided with a first sub-end cover 523-1 and a second sub-end cover 523-2, respectively. In some embodiments, as Figure 8As shown, the first sub-slot 511-1 and the second sub-slot 511-2 can be opened on the same side of the housing 510. The first sub-slot 511-1 and the second sub-slot 511-2 can both be arranged in a long strip shape. In some alternative embodiments, the first sub-slot 511-1 and the second sub-slot 511-2 can also be arranged on the housing 510 in other ways. For example, the first sub-slot 511-1 and the second sub-slot 511-2 can be arranged on opposite sides of the housing 510. The first sub-control part 520-1 and the second sub-control part 520-2 can move in the first sub-slot 511-1 and the second sub-slot 511-2 respectively, so as to drive the first sub-connecting rod 521-1 and the second sub-connecting rod 521-2 to move respectively, and the first sub-connecting rod 521-1 and the second sub-connecting rod 521-2 can control separate traction ropes (such as the first traction rope and the second traction rope) respectively, so as to realize the separate control of the first inner clamping arm 211 and the second inner clamping arm 213 of the inner clamping arm 210. Taking the first traction rope as an example, the first traction rope can pass through the through hole of the movable end of the first inner clamping arm 211, the first traction rope passes through the inner hole of the first sub-connecting rod 521-1, and the two ends of the first traction rope can be fixed at the first sub-end cover 523-1.

[0045] In some embodiments, the second control unit 520 (such as the first sub-control unit 520-1 or the second sub-control unit 520-2) may include a control button 533 and a connector 537. The control button 533 may pass through the second slide slot 511 and be connected (fixedly connected or movably connected) to the connector 537. The connector 537 may be fixedly connected to the outer wall of the connecting rod 521 by gluing, welding, or clamping.

[0046] In some embodiments, the control button 533 may be movably connected to the connector 537 via a spring (not shown). For example, the connector 537 may be provided with a blind hole, one end of the control button 533 may be provided with a connecting shaft that can be extended and retracted in the blind hole, and the end of the connecting shaft may be connected to the blind hole via a spring. The other end of the control button 533 may pass through the second slide slot 511 and be exposed from the housing 510. Figure 9-10As shown, a protrusion 535 is provided on the control button 533, and a groove 539 is provided on the housing 510. The protrusion 535 can be engaged with the groove 539 under the action of the spring to limit the movement of the second control part 520 relative to the second slide groove 511. When controlling the inner clamp arm 210, the operator can press the control button 533 to make the protrusion 535 disengage from the groove 539 to overcome the elastic force of the spring, and then the operator can push and pull the control button 533 to control the movement of the second control part 520 relative to the second slide groove 511. When the second control part 520 has moved and is located at the corresponding position of the groove 539, the operator releases the control button 533, and the protrusion 535 is engaged with the groove 539 under the elastic force of the spring, thereby limiting the movement of the second control part 520 relative to the second slide groove 511. Through the coordinated arrangement of the groove 539 and the protrusion 535, the operator can effectively avoid misoperation during surgery.

[0047] In some embodiments, one or more grooves 539 may be provided on the housing 510. Preferably, the housing 510 may include two grooves 539 respectively provided at both ends of the second slide 511. When the protrusion 535 is respectively engaged with the two grooves 539, the second control part 520 is respectively located at both ends of the second slide 511. When the second control part 520 is located at the rear end of the second slide 511, the inner clamp arm 210 may be in a retracted state. When the second control part 520 is located at the front end of the second slide 511, the inner clamp arm 210 may be in a maximum openable state (the specific opening condition also depends on the state of the outer clamp arm 220). By only providing two grooves 539 at both ends of the second slide 511, it can be more convenient for the operator to use on the basis of meeting the surgical requirements, and can further avoid the operator's misoperation during the operation. In some alternative embodiments, a plurality of grooves 539 may be provided on the housing 510, so that the second control part 520 can be restricted at multiple positions, which is conducive to the operator to operate more accurately.

[0048] In some embodiments, the first sub-control unit 520-1 and the second sub-control unit 520-2 can be configured to be linked or separated according to actual needs, so as to accurately control the inner clamp arm 210 according to the needs of the experiment or surgery. For example, during the mitral valve repair process, the first inner clamp arm 211 can be controlled to clamp one side of the mitral valve and then the second inner clamp arm 213 can be controlled to clamp the other side of the mitral valve. For another example, the second control unit 520 can simultaneously control the first inner clamp arm 211 and the second inner clamp arm 213 to clamp the mitral valve. In some embodiments, in order to facilitate the operator to identify the first sub-control unit 520-1 and the second sub-control unit 520-2, a mark can be added to the control button 533. The mark can be "left", "right", "L", "R" or an arrow, etc.

[0049] Fig.11is a schematic structural diagram of an outer clamp arm control mechanism according to some embodiments of the present application; Fig.12 is a partial structural schematic diagram of an outer clamp arm control mechanism according to some embodiments of the present application; Fig.13 is a schematic diagram of the structure of the sliding part according to some embodiments of the present application. Figure 11-13 As shown, the outer clamp arm control mechanism 400 may include a sleeve 410, a first control portion 420 and a sliding portion 430. The sliding portion 430 is disposed in the sleeve 410; the first control portion 420 can drive the sliding portion 430 to move in the sleeve 410 along the length direction of the sleeve 410 by rotation to control the opening and closing of the outer clamp arm 220. If the end of the control handle 300 close to the tissue clamping device 200 is defined as the front end, and the other end of the control handle 300 is defined as the rear end, the sliding portion 430 moves toward the front end in the sleeve 410 to control the opening of the outer clamp arm 220 (such as the relative opening of the first outer clamp arm 221 and the second outer clamp arm 223), and the sliding portion 430 moves toward the rear end to control the closing of the outer clamp arm 220.

[0050] In some embodiments, the inner circumference of the first control part 420 is provided with an internal thread, the sliding part 430 is provided with an external thread, and the sleeve 410 is provided with a first slide groove 412 along the length direction. The sliding part 430 can pass through the first slide groove 412 and the external thread on the sliding part 430 can match with the internal thread of the first control part 420, so that when the first control part 420 rotates, it can drive the sliding part 430 to move along the first slide groove 412. In this embodiment, two first slide grooves 412 can be provided on the sleeve 410, which are respectively located on opposite sides of the sleeve 410, and two external threads are correspondingly provided on the sliding part 430, and the two external threads can respectively pass through the two first slide grooves 412 to extend outward and match with the internal thread of the first control part 420. By providing two first slide grooves 412 and two external threads, the stability of the first control part 420 driving the sliding part 430 to move can be ensured. In some alternative embodiments, the number of the above-mentioned first slide grooves 412 can also be one, three or five.

[0051] In some embodiments, Figure 11-13As shown, the outer clamp arm control mechanism 400 may include a driving rod 440, a fixing block 460 and a protective cover 470; the sliding portion 430 may be connected to the driving rod 440 and control the opening and closing of the outer clamp arm 220 through the driving rod 440, and the rear end of the driving rod 440 is fixedly connected to the fixing block 460. Specifically, the fixing block 460 may be cylindrical, and its cross-sectional diameter may be larger than the cross-sectional diameter of the driving rod 440. The driving rod 440 may be inserted into the fixing block 460 and fixedly connected to the fixing block 460 by means of gluing, welding or interference connection. The protective cover 470 may be detachably connected to the sliding portion 430 by threads; when the protective cover 470 is connected to the sliding portion 430, the protective cover 470 can limit the relative movement of the fixing block 460 and the sliding portion 430. In some embodiments, the driving rod 440 can be made of a memory alloy (such as nickel-titanium alloy), so that the driving rod 440 can have better tensile and compressive resistance and better bending performance; and then when the delivery tube 600 is bent, the outer clamp arm control mechanism 400 can also effectively control the opening and closing of the outer clamp arm 220 through the driving rod 440.

[0052] In some embodiments, the sleeve 410 can be connected to (or integrally formed with) one end of the housing 510, and the central axes of the housing 510 and the sleeve 410 coincide, so that the control handle 300 is more compact and easier to operate. For example, the housing 510 can be disposed at one end of the sleeve 410 close to the tissue clamping device 200. In some alternative embodiments, the housing 510 can also be disposed at one end of the sleeve 410 away from the tissue clamping device 200.

[0053] In some embodiments, the first control part 420 may have a circular outer contour, and a rubber layer may be provided on the surface of the outer contour. When the operator controls the outer clamp arm 220 by rotating the first control part 420, the rubber layer can increase the friction between the first control part 420 and the palm or finger, so that the operator can achieve precise control. In other embodiments, the outer contour surface of the first control part 420 may not be provided with a rubber layer but may be made of a hard material such as plastic, metal, etc., and anti-slip grooves may be provided on its surface to increase surface friction.

[0054] In some embodiments, when the tissue clamping device 200 has completed clamping, the driving rod 440 needs to be separated from the tissue clamping device 200 and withdrawn from the control handle 300 (eg, completely withdrawn or withdrawn a certain distance). Fig.13 As shown, the protective cover 470 is detachably connected to the sliding portion 430 through a thread. When the driving rod 440 needs to be disengaged, the operator can rotate the protective cover 470 to disengage it from the sliding portion 430, and then the operator can rotate the fixing block 460 (i.e., rotate the driving rod 440) to separate the driving rod 440 from the tissue clamping device, and then the operator can pull the fixing block 460 to withdraw the driving rod 440 from the control handle 300.

[0055] Fig.14 is a schematic diagram of an exploded structure of a control handle according to some embodiments of the present application; Fig.15 is a schematic diagram of the structure of the guide block according to some embodiments of the present application. Figure 14-15 As shown, the control handle 300 of the embodiment of the present application may also include a guide block 540. The guide block 540 may include three through holes A, B and C arranged at intervals, and the central axes of the through holes A, B and C are located on a first plane. The first plane is the plane where the central axes of the through holes A, B and C are located. In some embodiments, through holes A and C are located on both sides of the guide block 540, and are used to guide the connecting rod 521 that controls the movement of the inner clamp arm 210 (such as through hole A is used to guide the first sub-connecting rod 521-1, and through hole C is used to guide the second sub-connecting rod 521-2), and through hole B is located in the middle of through holes A and C, and is used to guide the driving rod 440 that controls the movement of the outer clamp arm 220. On one side of the first plane (such as Fig.15 The through hole A and the through hole B can be connected to each other through a hose (not shown in the figure), and on the other side of the first plane (as shown in the figure) Fig.15 The through hole B and the through hole C can be connected to each other through a hose to ensure good sealing of the guide block 540. Specifically, taking the example of through hole A and through hole B being connected to each other through a hose, a first through hole 541 can be provided in the middle of through hole A, extending from the inside of through hole A to Fig.15 The top surface of the guide block 540 shown in FIG. 1 is a top surface of the guide block 540; a second through hole 542 may be provided in the middle of the through hole B, which penetrates from the inside of the through hole B to the top surface of the guide block 540. The outlets of the first through hole 541 and the second through hole 542 on the top surface of the guide block 540 may be connected to each other through a hose. In some embodiments, a sealing member (such as a sealing ring, etc.) may be provided between the rear end of the guide block 540 (such as the rear end of the through holes A, B, and C) and the housing 510 (such as an internal baffle provided on the housing 510), so as to further ensure the sealing of the control handle 300, thereby ensuring the smooth progress of the operation.

[0056] The beneficial effects that may be brought about by the embodiments of the present application include but are not limited to: (1) being able to precisely control the outer clamp arm and / or the inner clamp arm of the tissue clamping device; (2) being able to facilitate the production and manufacturing of the control handle; (3) being able to conveniently detach the control handle from the tissue clamping device; (4) being able to make the operation of mitral valve repair more convenient, and the efficiency and success rate of the repair higher; (5) being able to prevent misoperation in multiple links. It should be noted that different embodiments may produce different beneficial effects. In different embodiments, the beneficial effects that may be produced may be any one or a combination of the above, or any other possible beneficial effects.

[0057] The above are only preferred embodiments of the present application and are not intended to limit the present application. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present application should be included in the protection scope of the present application.

Claims

1. An inner clamp arm control mechanism, characterized in that: It includes a housing, a second control part and a connecting rod; The housing is provided with a second slide groove, and the second control part passes through the second slide groove and is fixedly connected to the outer wall of the connecting rod; The second control part can move along the second slide groove to drive the connecting rod to move, and the movement of the connecting rod can control the movement of the inner clamping arm of the tissue clamping device; the second control part includes a control button and a connecting body, the control button passes through the second slide groove and is connected to the connecting body, and the connecting body is fixedly connected to the outer wall of the connecting rod; The control button is movably connected to the connecting body via a spring; The housing is provided with a groove, and the button is provided with a bulge, and the bulge can be engaged with the groove under the action of the spring to limit the movement of the second control part relative to the second sliding groove.

2. The inner clamp arm control mechanism according to claim 1, characterized in that: The connecting rod controls the movement of the inner clamp arm through a traction rope; The connecting rod comprises an inner hole, the traction rope passes through the inner hole of the connecting rod, and two ends of the traction rope are detachably connected to the rear end of the connecting rod.

3. The inner clamp arm control mechanism according to claim 1, characterized in that: The second control unit includes a first sub-control unit for controlling the first inner clamp arm and a second sub-control unit for controlling the second inner clamp arm; The second chute includes a first sub-chute and a second sub-chute corresponding to the first sub-control part and the second sub-control part respectively.

4. The inner clamp arm control mechanism according to claim 1, characterized in that: At least two grooves are provided on the housing, and when the protrusions are respectively engaged with the two grooves, the second control portion is located at two ends of the second sliding groove.

5. The inner clamp arm control mechanism according to claim 4, characterized in that: When the protrusions are respectively engaged with the two grooves, the second control part is located at two ends of the second slide groove, and includes: When the second control portion is located at the rear end of the second slide slot, the inner clamp arm is in a retracted state; When the second control portion is located at the front end of the second sliding slot, the inner clamping arm is in a maximum expandable state.

6. A mitral valve repair control handle, characterized in that: The invention comprises the inner clamp arm control mechanism as claimed in any one of claims 1 to 5.

7. The mitral valve repair control handle according to claim 6, characterized in that: The mitral valve repair control handle also includes an outer clamp arm control mechanism for controlling the movement of the outer clamp arm of the tissue clamping device; The outer clamp arm control mechanism includes a sleeve, a first control part, a sliding part and a driving rod, wherein the sliding part is arranged in the sleeve and connected to the driving rod; the first control part can drive the sliding part to move in the sleeve along the length direction of the sleeve by rotating, thereby driving the driving rod to move to control the opening and closing of the outer clamp arm; wherein, An internal thread is provided on the inner circumference of the first control part; an external thread is provided on the sliding part; a first sliding groove is provided on the sleeve along the length direction; the sliding part passes through the first sliding groove and the external thread on the sliding part matches the internal thread of the first control part.

8. The mitral valve repair control handle according to claim 6, characterized in that: The mitral valve repair control handle also includes a guide block; The guide block comprises three through holes A, B and C arranged at intervals, wherein the central axes of the three through holes are located on the first plane, wherein the through holes A and C on both sides are used to guide the connecting rod for controlling the movement of the inner clamp arm, and the through hole B in the middle is used to guide the driving rod for controlling the movement of the outer clamp arm; On one side of the first plane, the through hole A and the through hole B are connected to each other through a hose, and on the other side of the first plane, the through hole B and the through hole C are connected to each other through a hose.

9. A mitral valve repair device, characterized in that: Comprising a mitral valve repair control handle as described in any one of claims 6-8.

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