Incubation tank assembly of biochemical analyzer and biochemical analysis method

Abstract

The present invention belongs to the technical field of biochemical analyzers, and provides a incubation tank assembly for a biochemical analyzer. By arranging a puncture position and a sample addition position communicated with a linear channel at intervals along the direction of the linear channel on the upper surface of the incubation tank having a linear channel inside, arranging a detection position communicated with the linear channel on the side surface of the incubation tank, and arranging a driving mechanism capable of driving a chip cartridge internally sealed with a disposable test reagent to pass on one side of the linear channel, the generation of the problem of the expiration date after opening the bottle and the operation of the "calibration" process are effectively avoided, so that the detection process of the biochemical detector equipped with the incubation tank assembly is simple and immediate, and the detection accuracy is improved.

Description

Technical Field

[0001] The present invention belongs to the technical field of biochemical analyzers, and particularly relates to a warming tank assembly of a biochemical analyzer and a biochemical analysis method. Background Art

[0002] Currently, an annular warming tank is often used in a biochemical detector to place reagent bottles and reaction cups. Among them, the reagent bottle contains reagent amounts for multiple persons for detecting multiple samples. During specific sample detection, the reagent bottle is opened, and then a reagent suction device is used to suck the reagent and mix it with the sample in the reaction cup for detection. Summary of the Invention

[0003] Although the annular warming tank of the existing biochemical detector can achieve sample detection, since the market positioning of the existing biochemical detector with an annular warming tank is usually for large medical institutions, the annular warming tank needs to be able to place multiple reaction cups and reagent bottles with a large amount of reagent measurement to meet the requirements of multiple-person testing. However, it is found in practice that the reagent in the reagent bottle usually cannot be used up after opening, thus causing the problem of the opening validity period, that is, the remaining reagent after opening may cause a decrease in the detection accuracy of the sample when used again after a certain period of time. In addition, the reaction cups and reagent bottles in the annular warming tank exist independently, which is usually an important reason for the complex "calibration" process required during sample detection. "Calibration" requires professional operation and the operation process is complex, so that the biochemical analyzer with an annular warming tank cannot be popularized in small medical institutions such as community hospitals at all.

[0004] In summary, the annular warming tank of the existing biochemical detector has defects such as complex detection procedures of the biochemical detector and easy reduction of detection accuracy.

[0005] The present invention provides a warming tank assembly of a biochemical analyzer to solve the above defects of the annular warming tank of the existing biochemical detector. The warming tank assembly of the biochemical analyzer includes:

[0006] A warming tank with a linear channel inside; a puncture position and a sample addition position communicating with the linear channel are arranged at intervals along the direction of the linear channel on the upper surface of the warming tank; a detection position communicating with the linear channel is arranged on the side surface of the warming tank for biochemical detection; a driving mechanism for driving a chip box containing a disposable test reagent to pass is arranged on one side of the linear channel.

[0007] Further, the driving mechanism drives the chip box to pass by driving a clamping and limiting mechanism to move.

[0008] Further, the clamping and limiting mechanism includes a limiting block and front and rear sliders connected by a spring; the limiting block limits the chip cassette; one side of the front and rear sliders is provided with a rotary hook that can rotatably clamp the chip cassette, and the other side is connected to the driving mechanism.

[0009] Further, the incubation tank is of a long strip structure.

[0010] Further, a position sensor for sensing the position information of the chip cassette is also provided on one side of the incubation tank.

[0011] Further, the position sensor is arranged near the chip cassette inlet of the linear channel.

[0012] Further, the distance between the puncture position and the chip cassette inlet of the linear channel is farther than the distance between the sample addition position and the chip cassette inlet of the linear channel.

[0013] Further, a chip cassette identification position is also provided on one side of the incubation tank; the chip cassette identification position is communicated with the linear channel, and the distance from the chip cassette inlet of the linear channel is farther than the distance between the puncture position and the chip cassette inlet of the linear channel.

[0014] Further, the detection position is arranged between the chip cassette identification position and the puncture position, and includes a transmission detection position and / or a scattering detection position.

[0015] In addition, the present invention provides a biochemical analysis method, including:

[0016] Intermittently arranging a puncture position and a sample addition position communicated with the linear channel along the direction of the linear channel on the upper surface of an incubation tank having a linear channel inside;

[0017] Arranging a detection position communicated with the linear channel on the side surface of the incubation tank for biochemical detection;

[0018] Arranging a driving mechanism capable of driving a chip cassette containing a disposable test reagent to pass on one side of the linear channel.

[0019] The incubation tank assembly of the biochemical analyzer provided by the present invention, by intermittently arranging a puncture position and a sample addition position communicated with the linear channel along the direction of the linear channel on the upper surface of an incubation tank having a linear channel inside, arranging a detection position communicated with the linear channel on the side surface of the incubation tank, and arranging a driving mechanism capable of driving a chip cassette containing a disposable test reagent to pass on one side of the linear channel, effectively avoids the problem of the expiration date of opening a bottle and the operation of the "calibration" process, thereby making the detection process of the biochemical detector equipped with this incubation tank assembly simple and immediate, and improving the detection accuracy. Description of the Drawings

[0020] Figure 1 Schematic structural diagram of the incubation tank assembly of a biochemical analyzer provided for an embodiment;

[0021] Figure 2 Schematic structural diagram of the incubation tank assembly of a biochemical analyzer provided for an improved embodiment;

[0022] Figure 3 Schematic structural diagram of the incubation tank assembly of a biochemical analyzer provided for an improved embodiment;

[0023] Figure 4 Process flow chart of the method of a biochemical analyzer provided for an embodiment. Detailed implementation manners

[0024] In order to make the objectives, technical solutions and advantages of the present invention clearer and more understandable, the present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention. In the description of the present invention, it should be noted that the orientation or positional relationship indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. is based on the orientation or positional relationship shown in the accompanying drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as a limitation of the present invention.

[0025] In addition, in the description of the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected, or indirectly connected through an intermediate medium, and can also be the communication inside two elements. It can be a wireless connection or a wired connection. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific situations.

[0026] In addition, the technical features involved in different embodiments of the present invention described hereinafter can be combined with each other as long as they do not conflict with each other.

[0027] Next, the present invention proposes some preferred embodiments to teach those skilled in the art to implement.

[0028] Figure 1 Schematic structural diagram of the incubation tank assembly of a biochemical analyzer provided for an embodiment, showing an incubation tank assembly of a biochemical analyzer, the incubation tank assembly of the biochemical analyzer includes:

[0029] See Figure 1, an incubation tank 205 with a linear channel inside; along the direction of the linear channel on the upper surface of the incubation tank 205, a puncture position 2052 and a sample addition position 2051 communicating with the linear channel are provided at intervals; on the side surface of the incubation tank 205, detection positions (2054, 2055) communicating with the linear channel are provided for biochemical detection; on one side of the linear channel, a driving mechanism 203 is provided to drive a chip cartridge 204 containing a disposable test reagent to pass through.

[0030] In this embodiment, by arranging a puncture position 2052 and a sample addition position 2051 communicating with the linear channel at intervals along the direction of the linear channel on the upper surface of the incubation tank 205 with a linear channel inside, arranging detection positions (2054, 2055) communicating with the linear channel on the side surface of the incubation tank 205, and arranging a driving mechanism 203 on one side of the linear channel to drive a chip cartridge 204 containing a disposable test reagent to pass through, the problem of the opening expiration date and the operation of the "calibration" process are effectively avoided, so that the detection process of the biochemical analyzer with the incubation tank 205 assembly is instantaneously simple and the detection accuracy is improved.

[0031] It should be noted that since the test reagent sealed in the chip cartridge 204 is a disposable reagent for single-person use, the test reagent is pre-sealed in the chip cartridge 204 through a sealing film in a single-use dosage. At the same time, the pre-sealed reagent has been calibrated through a special "calibration" process, and no complex operation of reagent "calibration" is required when using the test reagent, so that the detection process of the biochemical analyzer with the incubation tank 205 assembly is instantaneously simple. Among them, because the test reagent is a sealed disposable single-person use reagent, the problem of the opening expiration date can be effectively avoided, and the test accuracy will not be reduced due to the retention of the reagent and its reuse.

[0032] In addition, when specifically using the incubation tank assembly of the biochemical analyzer in this embodiment to detect and analyze a sample, the chip cartridge 204 is placed into the chip cartridge 204 entrance of the linear channel, and then the chip cartridge 204 is driven by the driving mechanism 203 to pass through the linear channel, receive the puncture of the sealing film of the chip cartridge 204 by the puncture position 2052, receive the sample addition to the punctured chip cartridge 204 by the sample addition position 2051, and then receive the analysis of the biochemical reaction value of the reactant after mixing the sample and the reagent by the detection positions (2054, 2055), so that an instant, efficient and simple sample test can be realized.

[0033] In addition, compared with the biochemical analyzer in the prior art that uses an annular incubation tank to place reagent bottles and reaction cups, and the reagent bottles contain reagent amounts for multiple samples for detecting multiple samples, the biochemical analyzer with the incubation tank assembly provided in this embodiment has the advantages that the detection process is instantaneously simple and the detection accuracy is relatively high.

[0034] Specifically, the incubation tank 205 can be set as a long strip structure. The incubation tank 205 with a long strip structure is conducive to setting a straight channel, which is beneficial to setting the puncture position 2052, the sample adding position 2051 and the detection positions (2054, 2055) along the straight channel, so that other mechanisms of the biochemical analyzer can be set along the incubation tank 205 with a long strip structure, thereby achieving the effect of concentrating the mechanism positions to reduce the overall volume of the biochemical analyzer.

[0035] It should also be noted that biochemical detection is a specific detection method, that is, a method of irradiating a sample by means of light passing through the side wall of the chip cartridge for detection. Therefore, the part of the side wall of the chip cartridge 204 opposite to the detection positions (2054, 2055) needs to be light-transmissive so that light can pass through and irradiate the sample to be detected. Since the detection positions (2054, 2055) communicating with the straight channel are arranged on the side surface of the incubation tank 205, an optical path can be established to realize biochemical analysis of the sample. At the same time, by irradiating the side wall of the chip cartridge 204 through the optical path, the light passes through the light-transmissive side wall to irradiate the sample, and then the light is detected by transmission turbidimetry and / or scattering turbidimetry, so as to obtain the sample detection result.

[0036] It should also be noted that the incubation tank 205 has the functions of storing reactants at a constant temperature and providing a suitable reaction temperature, which can be specifically composed of a heating device, a temperature sensor, a temperature regulating device, etc.

[0037] Based on Figure 1 the disclosure of the embodiments in Figure 2 FIG. 13 is a schematic structural diagram of an incubation tank assembly of a biochemical analyzer provided for an improved embodiment, showing a clamping and limiting mechanism of an incubation tank assembly of a biochemical analyzer.

[0038] See Figure 1-2 , the driving mechanism 203 drives the chip cartridge 204 to pass by driving the clamping and limiting mechanism to move. Specifically, the clamping and limiting mechanism includes a limiting block 2020 and front and rear sliders (2021, 2023) connected by springs; the limiting block 2020 limits the chip cartridge 204; on one side of the front and rear sliders (2021, 2023), there is a rotary hook that can rotatably clamp the chip cartridge 204, and on the other side, it is connected to the driving mechanism 203.

[0039] In this embodiment, the driving mechanism 203 drives the chip cassette 204 to pass by driving the clamping and limiting mechanism, and can realize clamping the chip cassette 204 for bidirectional transportation and accurate positioning at the required position. Among them, the front and rear sliders (2021, 2023) are connected by a spring, and a rotating hook for rotatably clamping the chip cassette 204 is arranged on one side of the front and rear sliders (2021, 2023). The spring force can drive the movement of the front and rear sliders (2021, 2023), and then drive the rotating hook on the front and rear sliders (2021, 2023) to rotate to clamp the chip cassette 204 seamlessly, thereby improving the positioning accuracy of the chip cassette 204. In addition, the driving mechanism 203 can select linear driving mechanisms 203 such as a conveyor belt module and a lead screw motor module to achieve the purpose of driving the chip cassette 204 to travel back and forth along a straight channel.

[0040] Based on Figure 1 or Figure 2 the disclosure of the embodiment in Figure 3 FIG. is a schematic structural diagram of an incubation tank assembly of a biochemical analyzer provided for an improved embodiment, showing a station layout structure of a biochemical analyzer.

[0041] See Figure 1-3 , a position sensor for sensing the position information of the chip cassette 204 is further provided on one side of the incubation tank 205, and the position sensor can be arranged near the entrance of the chip cassette 204 in the straight channel. A chip cassette identification position is further provided on one side of the incubation tank 205, and the chip cassette identification position 2053 communicates with the straight channel. Among them, the position sensor and the chip cassette identification position 2053 can be arranged on the same side of the incubation tank 205 as the puncture position 2052 and the sample addition position 2051, or can be arranged on different sides of the incubation tank 205 from the puncture position 2052 and the sample addition position 2051.

[0042] The distance between the chip cassette identification position 2053 and the entrance of the chip cassette 204 in the straight channel can be farther than the distance between the puncture position 2052 and the entrance of the chip cassette 204 in the straight channel, or can be closer than the distance between the puncture position 2052 and the entrance of the chip cassette 204 in the straight channel. The distance between the puncture position 2052 and the entrance of the chip cassette 204 in the straight channel can be farther than the distance between the sample addition position 2051 and the entrance of the chip cassette 204 in the straight channel, or can be closer than the distance between the sample addition position 2051 and the entrance of the chip cassette 204 in the straight channel. Between the chip cassette identification position 2053 and the puncture position 2052, detection positions (2054, 2055) can be set, and the detection positions (2054, 2055) include a transmission detection position 2054 and / or a scattering detection position 2055, and the transmission detection position 2054 and / or the scattering detection position 2055 can be arranged side by side.

[0043] In a preferred embodiment, with reference to the entrance of the chip cartridge 204 in the linear channel, the distances of the in-place sensor, the sample addition position 2051, the puncture position 2052, the detection positions (2054, 2055), and the chip cartridge identification position 2053 from the entrance of the chip cartridge 204 in the linear channel thus become farther.

[0044] It should be noted that setting an in-place sensor near the entrance of the chip cartridge 204 in the linear channel can detect whether the chip cartridge 204 is in place in the first place, thereby triggering the progress of further processes. By setting a transmission detection position 2054 and / or a scattering detection position 2055 between the chip cartridge identification position 2053 and the puncture position 2052, an optical path can be established to realize biochemical analysis of the sample. By setting the chip cartridge identification position 2053 on one side of the incubation tank 205, the identification information (such as a two-dimensional code) of the chip cartridge 204 can be recognized, and the identity information of the chip cartridge 204 can be confirmed, thereby avoiding errors in the detection object.

[0045] Corresponding Figure 1 to the disclosure of the Figure 4 middle embodiment,

[0046] See Figure 1 and Figure 4 This biochemical analysis method provided by this embodiment includes:

[0047] S0. Intermittently set a puncture position 2052 and a sample addition position 2051 that communicate with the linear channel along the direction of the linear channel on the upper surface of an incubation tank 205 having a linear channel inside;

[0048] S1. Set detection positions (2054, 2055) that communicate with the linear channel on the side surface of the incubation tank 205 for biochemical detection;

[0049] S2. Set a driving mechanism 203 on one side of the linear channel that can drive a chip cartridge 204 containing a disposable test reagent to pass through.

[0050] In this embodiment, by intermittently setting a puncture position 2052 and a sample addition position 2051 that communicate with the linear channel along the direction of the linear channel on the upper surface of an incubation tank 205 having a linear channel inside, setting detection positions (2054, 2055) that communicate with the linear channel on the side surface of the incubation tank 205, and setting a driving mechanism 203 on one side of the linear channel that can drive a chip cartridge 204 containing a disposable test reagent to pass through, the generation of the open bottle expiration date problem and the operation of the "calibration" process are effectively avoided, thereby making the overall volume of the biochemical detector equipped with this incubation tank assembly small, the detection process instant and simple, and the detection accuracy improved.

[0051] It should be noted that since the test reagent sealed in the chip cartridge 204 is a single-use reagent for one person, the test reagent is pre-sealed in the chip cartridge 204 in a single-use measurement through a sealing film. At the same time, the pre-sealed reagent has been calibrated through a special "calibration" process. When using the test reagent, there is no need to perform complex operations of reagent "calibration", which makes the detection process of the biochemical analyzer equipped with this incubation tank assembly simple and immediate. Among them, because the test reagent is a sealed single-use reagent for one person, the problem of the expiration date after opening the bottle can be effectively avoided, and the test accuracy will not be reduced due to the reuse of the retained reagent.

[0052] In addition, when specifically using the incubation tank assembly of the biochemical analyzer in this embodiment to detect and analyze a sample, the chip cartridge 204 is placed into the chip cartridge 204 inlet of the linear channel, and then the chip cartridge 204 is driven by the driving mechanism 203 to travel in the linear channel, where it receives the puncture of the sealing film of the chip cartridge 204 by the puncture position 2052, receives the sample addition to the punctured chip cartridge 204 by the sample addition position 2051, and then receives the analysis of the biochemical reaction value of the reactant after mixing the sample and the reagent by the detection positions (2054, 2055), so that an immediate, efficient and simple sample test can be achieved.

[0053] In addition, compared with the existing biochemical analyzer that uses an annular incubation tank to place reagent bottles and reaction cups, and the reagent bottles are filled with reagent amounts for multiple people to detect multiple samples, the biochemical analyzer with the incubation tank assembly provided in this embodiment has the advantages of simple and immediate detection process and relatively high detection accuracy.

[0054] Specifically, the incubation tank 205 can be set as a long strip structure. The long strip structure of the incubation tank 205 is conducive to setting a linear channel, and is beneficial to setting the puncture position 2052, the sample addition position 2051 and the detection positions (2054, 2055) along the linear channel, so that other mechanisms of the biochemical analyzer can be set along the long strip structure of the incubation tank 205, thereby achieving the effect of concentrating the mechanism positions to reduce the overall volume of the biochemical analyzer.

[0055] It should also be noted that since the detection positions (2054, 2055) communicating with the linear channel are provided on the side of the incubation tank 205, an optical path can be established to realize the biochemical analysis of the sample. At the same time, the side wall of the chip cartridge 204 is irradiated by light through the optical path, and the light irradiates the sample through the light-transmitting side wall, and then the light is detected by transmission turbidimetry and / or scattering turbidimetry, so as to obtain the sample detection result.

[0056] It should also be noted that the incubation tank 205 has the functions of storing the reactant at a constant temperature and providing a suitable reaction temperature, which can be specifically composed of a heating device, a temperature sensor and a temperature regulating device, etc.

[0057] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. A incubation tank assembly of a biochemical analyzer, characterized in that, Comprising: An incubation tank with a straight channel inside; on the upper surface of the incubation tank, a puncture position and a sample addition position communicating with the straight channel are arranged at intervals along the direction of the straight channel; on the side surface of the incubation tank, a detection position communicating with the straight channel is provided for biochemical detection; on one side of the straight channel, a driving mechanism for driving a chip cartridge containing a disposable test reagent to pass through is arranged, and an identification position for the chip cartridge is further provided on one side of the incubation tank; the identification position for the chip cartridge communicates with the straight channel, and the distance from the identification position for the chip cartridge to the chip cartridge inlet of the straight channel is farther than the distance from the puncture position to the chip cartridge inlet of the straight channel; the driving mechanism drives the chip cartridge to pass through by driving a clamping and limiting mechanism to move; the clamping and limiting mechanism includes a limiting block and front and rear sliders connected by a spring, the limiting block limits the chip cartridge, and on one side of the front and rear sliders, a rotary hook for rotatably clamping the chip cartridge is provided, and one side is connected to the driving mechanism.

2. The incubation tank assembly of the biochemical analyzer according to claim 1, characterized in that, The incubation tank is of a long strip structure.

3. The incubation tank assembly of the biochemical analyzer according to claim 1, characterized in that, On one side of the incubation tank, a position sensor for sensing the position information of the chip cartridge is further provided.

4. The incubation tank assembly of the biochemical analyzer according to claim 3, characterized in that, The position sensor is arranged near the chip cartridge inlet of the straight channel.

5. The incubation tank assembly of the biochemical analyzer according to claim 1, characterized in that, The distance from the puncture position to the chip cartridge inlet of the straight channel is farther than the distance from the sample addition position to the chip cartridge inlet of the straight channel.

6. The incubation tank assembly of the biochemical analyzer according to claim 1, characterized in that, The detection position is arranged between the identification position for the chip cartridge and the puncture position, and includes a transmission detection position and / or a scattering detection position.

7. A biochemical analysis method, applied to the incubation tank assembly of the biochemical analyzer according to any one of claims 1-6, characterized in that, Comprising: On the upper surface of an incubation tank with a straight channel inside, a puncture position and a sample addition position communicating with the straight channel are arranged at intervals along the direction of the straight channel; On the side surface of the incubation tank, a detection position communicating with the straight channel is provided for biochemical detection; On one side of the straight channel, a driving mechanism for driving a chip cartridge containing a disposable test reagent to pass through is arranged.

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