System and method for making personalized individual unit doses containing pharmaceutically active substances

Abstract

Systems and methods for making and delivering personalized medical prescription drugs for individual patients are described. An individual unit dose (IUD) of a drug specific to an individual in need of treatment can be prepared by using a system that includes a networked control system in combination with manufacturing components specific to the IUD; and delivering the drug directly from the manufacturer to the patient.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] This application claims priority to U.S. Provisional Patent Application No. 62 / 688,107 filed on June 21, 2018, U.S. Provisional Patent Application No. 62 / 700,444 filed on July 19, 2018, and U.S. Provisional Patent Application No. 62 / 729,051 filed on September 10, 2018, the contents of which are incorporated herein by reference in their entirety. Technical Field

[0003] The present disclosure relates to systems and methods for making personalized individual unit doses (IUDs) to deliver a specified amount of active substances to an individual. Specifically, the present disclosure relates to methods for customizing the manufacture of IUDs according to an individual's prescription for a specific active substance and delivering the manufactured IUDs to a patient. Background Art

[0004] At present, IUD is available in various forms, including tablets, caplets, capsules, wafers, films, sheets, injection pens, creams, ointments, gels and syringes, etc. IUD is usually manufactured by a pharmaceutical manufacturer and contains one or more active substances according to a government-approved amount and a dosage for a government-approved indication. Usually, individual patients (human beings or other animals) are evaluated by medical professionals and prescriptions for specific treatment regimens are issued. Prescriptions are limited to government-approved and therefore commercially available dosages. The patient provides the prescription to a practicing prescription filler, such as a pharmacy, who holds an IUD stock purchased from a manufacturer. The prescription filler executes the prescription of an individual patient. In some cases, the prescription is communicated directly from a medical professional to the prescription filler. In other cases, the IUD is mailed to the patient from the prescription filler.

[0005] Currently, prescriptions are executed in accordance with government-approved dosage amounts, which are sufficient for patients in most cases, but not always the amount that a medical professional considers appropriate for the patient, such as off-label use of a drug. For example, a medical professional may inform a patient to cut the IUD in half so that only half (or some other portion) of the active substance is taken at any one time. Alternatively, a medical professional may instruct a patient to take a larger dose than the approved amount for a specific treatment. In some cases, a medical professional may prescribe the active substance and dosage for a medical indication different from the medical indication for which the specific active substance is approved. Currently, such off-label use and dosage changes are performed on a patient-by-patient basis, but what the current method of executing prescriptions lacks is a way to customize (personalize) a specific IUD for a specific individual, as well as a more efficient and cost-effective way to produce an IUD personalized to the medical needs of an individual patient. In addition, at present, pharmacies are mainly dispensers of IUDs, but some pharmacies are licensed compounders and are therefore allowed to provide certain compounding of drugs (combinations of ingredients including active substances), especially when two or more drugs (active substances) are to be incorporated into a prescription. In general, compounding refers to the practice of combining, mixing or changing drug ingredients to create drugs customized for the needs of individual patients by a licensed pharmacist, a licensed physician, or a person under the supervision of a licensed pharmacist in the case of an outsourcing facility. Compounding by pharmacists has obvious limitations due to the lack of manufacturing equipment, process knowledge, quality control, manufacturing facilities and expertise. Sometimes, FDA-approved drugs cannot meet the health needs of patients, for example, if the patient suffers from allergies and needs the drug to be prepared without a certain component (such as a dye); or if the elderly patient or child cannot swallow pills and needs the drug to be in liquid form or it is not available. In addition, compounded drugs are not approved by the FDA. This means that the FDA cannot verify the safety or effectiveness of compounded drugs. Consumers and medical professionals rely on the drug approval process to ensure that drugs are safe and effective and are manufactured according to federal quality standards. Compounded drugs lack FDA approval for manufacturing quality before such drugs can be marketed.

[0006] There is a need for a system for manufacturing ordered personalized IUDs that is efficient, less costly, and maintains the good manufacturing and quality control standards currently required by government agencies. There is also a need for a system and method for manufacturing ordered personalized IUDs that reduces or alleviates inventory, thereby further reducing overhead and costs associated therewith. Summary of the invention

[0007] A system for creating one or more personalized individual unit doses (IUDs) containing a prescribed amount of active substance for treating an individual is disclosed. The system includes: an apparatus for manufacturing the personalized IUD; and a networked system configured to electronically transmit health information measured from the individual. The apparatus is used to manufacture the IUD according to a medical prescription and is selected from the group consisting of: a film forming component, a capsule filling component, a tablet forming component, a tablet coating component, a blending (mixing) component, a powder forming component, a granulation component, a spray drying component, an extruder component, a compounding component, a packaging component, a labeling component, an embossing component, a scoring component, a quality control component, and a combination thereof. The health information is electronically transmitted to a medical professional who determines a medical prescription that includes a prescribed amount of active substance in the personalized IUD. The networked system may include a processor, a memory storage, and executable instructions; and at least one of a display device, an alphanumeric input device, a cursor control device, a drive unit, a machine-readable medium, and a signal generating device. The system may also include a biometric measurement module that interfaces with the individual. The biometric measurement module may include an invasive device and / or a non-invasive measurement device, or a combination thereof.

[0008] In another aspect of the present disclosure, a method for producing a personalized IUD containing an active substance for an individual is provided. The method includes: a) obtaining a biometric measurement result related to the health of the individual; b) transmitting the biometric measurement result to a manufacturer of a medical or prescription product; c) manufacturing an IUD according to a medical prescription specific to the individual; and d) delivering the IUD made according to the medical prescription to the individual. The method may also include the step of electronically transmitting the biometric measurement result of the individual to a medical professional authorized to write a medical prescription before the step of manufacturing the IUD, and / or electronically transmitting the medical prescription to the manufacturer. Manufacturing the IUD may include using a device and / or adding an active substance to a carrier matrix. Manufacturing the IUD may include the steps of forming the IUD in one or more separate holes and / or adding an active substance to an already formed IUD. The IUD can be a film, a wafer, a capsule, a tablet, a suspension, a solution, an ointment, a patch, a cream, a gel, a lozenge, an ampoule, a medicine bottle, a syrup, a tincture, a spirit, a lozenge, a fragrance, a liniment, an injection, or any combination thereof. When the IUD is a film, it can be monolayer or multilayer. The active substance can be in the first film layer, the second film layer, or both. The active substance can be selected from the group consisting of: small molecules, macromolecules, biological products, microorganisms, allergens, enzymes, and combinations thereof.

[0009] Another aspect is a method for creating one or more personalized individual unit doses (IUDs) containing a specified amount of active substance for distribution and administration to an individual. The method includes the following steps: (a) providing personal health information of the individual to a medical professional; (b) prescribing a medical prescription by the medical professional, the medical prescription including an amount of active substance to be administered to the individual determined at least in part based on the personal health information, the medical prescription including a treatment regimen for administering the specified amount of active substance per personalized individual unit dose (IUD); (c) electronically transmitting at least a portion of the medical prescription to a manufacturer of the IUD; (c) manufacturing the IUD using an apparatus for manufacturing a personalized IUD; and (d) distributing the IUD to the individual.

[0010] Embodiments of the disclosed subject matter will become apparent from the following detailed description, which is to be read in conjunction with the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0011] The following drawings are given by way of example only and not limitation, wherein like reference numerals, when used, indicate corresponding elements throughout the several views, and wherein:

[0012] Figure 1 is a block diagram of a system for manufacturing a personalized individual unit dose (IUD) to deliver a prescribed amount of an active substance to an individual;

[0013] Figure 2 is a flow chart of a method for manufacturing a personalized IUD to deliver a prescribed amount of active substance to an individual;

[0014] Figure 3 is a block diagram illustrating at least a portion of an exemplary machine in the form of a computing system configured to perform certain methods disclosed herein;

[0015] Figure 4 is a block diagram of a prescription fulfillment system for electronically creating a prescription and filling the prescription by manufacturing a personalized IUD according to the instructions of the prescription; and

[0016] Figure 5 is a flow chart of a method for electronically creating a prescription and filling the prescription by manufacturing a personalized IUD according to the instructions of the prescription.

[0017] It should be understood that the elements in the figures are illustrated for simplicity and clarity. Common but well-understood elements that may be used in a commercially feasible embodiment may not necessarily be shown to facilitate a less obstructed view of the illustrated embodiments. DETAILED DESCRIPTION

[0018] The present disclosure provides systems and methods for manufacturing personalized IUDs by using a network-enabled control system to measure, transmit, produce and deliver an IUD specific to a prescription provided to an individual. Thus, an individual (e.g., a patient) can communicate remotely with a medical professional and use medical equipment to measure biometrics indicated by a physician, and the various biometrics are used to allow the medical professional to diagnose a condition, treatment, regimen, and / or medical prescription. The medical prescription is then transmitted to a manufacturing plant, where a specific dosage form and dosage amount (i.e., IUD) is manufactured according to the prescription active substance, dosage form, and dosage amount per IUD.

[0019] Thus, in one aspect of the present disclosure, a method is provided for producing a personalized IUD directly from a manufacturer, meaning that the manufacturer is provided with patient prescription information and the prescription is executed by manufacturing the IUD according to the instructions of the prescription. The IUD is personalized for the individual and manufactured to order. Thus, the manufacturer IUD can then be shipped to a pharmacy, a medical professional, a distributor, or directly to the patient. Communication between the medical professional, the IUD manufacturer, and the individual patient can provide for modifying the prescription and therefore the manufacture of the IUD, as well as updating existing prescriptions and IUD manufacture.

[0020] The system and method for manufacturing personalized IUD disclosed herein solves the problems in the above-mentioned field. According to the present disclosure, personalized IUD can be sent directly to the patient from the manufacturer (or the manufacturer's distributor), thereby improving efficiency and cost and enjoying other benefits.

[0021] Furthermore, the present disclosure allows for tracking of patient prescription fulfillment history whereby the manufacturer can communicate directly with the patient and / or medical professional via a network-enabled control system for continued treatment, either the same or an improved treatment.

[0022] Figure 1 A block diagram of a system 10 for manufacturing a personalized individual unit dose (IUD) to deliver a specified amount of active substance to an individual 12 is shown. The system 10 according to the present invention generally includes an apparatus 13 operated by an IUD manufacturer 26 for manufacturing a personalized IUD; a network-enabled control system 18 configured to electronically transmit health information measured from the individual 12; and optionally a biometric measurement module 14, 16 that interfaces with the individual 12.

[0023] Biometric information is measured, obtained, and / or collected from the individual 12 using a wearable biometric measurement module 14 and / or a non-wearable biometric measurement module 16. Alternatively, the biometric information may be entered directly into a computer by the individual 12, or the medical professional 20 may receive the biometric information visually over a network, for example, the medical professional 20 may observe a patient via a network-enabled control system 18. The biometric information is thereby provided to the network-enabled control system 18 for processing and distribution. The processed biometric information is then provided to the medical professional 20. The medical professional 20 optionally has access to a patient database 22 and / or a medical information database 24. The network-enabled control system 18 has access to the patient database 22 so that patient-specific information may be utilized during the processing of the biometric information. Additional details regarding the network-enabled control system 18 are described in detail in the accompanying drawings. Figure 3 , which provides a block diagram of one embodiment of a network-enabled control system 18.

[0024] Once the biometric information of the individual 12 is collected and processed, the medical professional 20 can provide a prescription to the IUD manufacturer 26 based on the information obtained from the network-enabled control system 18, the patient database 22, and / or the medical information database 24, and the processed biometric information. Using the network-enabled control system 18, the IUD manufacturer 26 uses the prescription obtained from the medical professional 20 to manufacture an IUD, which can be in any form, non-limiting examples of which include a film 28, a tablet 30, a capsule 32, an injection 34, a patch 36, and / or other dosage form 38. The film 28, tablet 30, capsule 32, injection 34, patch 36, and / or other dosage form 38 is then provided to the user 12, ideally in appropriate packaging and ideally appropriately labeled with the name of the active substance (e.g., the name of the drug) as well as the dosage (i.e., the amount of the drug present in the IUD, commonly referred to as the "labeled amount") and instructions for use (e.g., how often to take a dose, before or after meals, precautions to take, or other important / useful instructions for use).

[0025] For the packaging and delivery of IUDs, the IUD manufacturer 26 can package each manufactured IUD separately for the individual 12, or can co-package (package together) multiple IUDs manufactured based on one or more prescriptions specific to the individual 12. The co-packaging method can combine all the drugs prescribed for the individual 12 in a given time period, thereby providing a simple and convenient delivery and compliance option for the individual 12, who may be required to take one or more drugs at different time intervals (e.g., morning, evening, daily, weekly, biweekly, bimonthly, and combinations thereof). Co-packaging can include a single packaged unit with an IUD for each day or for a specified dosage regimen, and the IUD may be more than one type of drug. For example, the patient 12 may be required to take two drugs at the same time but at different frequencies, i.e., take one drug every day and take another drug every week. In order to help the individual 12 correctly follow the medication instructions and properly comply with the prescription regimen, each manufactured IUD can include a mark (such as a color code) on its packaging, which contains the medication instructions. For example, a daily IUD pouch can be red, while a weekly IUD pouch can be blue.

[0026] Alternatively, a scannable code technology (such as a QR code) may be implemented to provide appropriate medication information and instructions for each packaged IUD or for each IUD itself (i.e., the code is printed or embossed on the IUD itself). The QR code may store any encrypted or unencrypted information or data related to the individual 12, the manufactured IUD, and the medication instructions, such as the individual's name, IUD manufacturer, drug name, labeled dosage, medication frequency (e.g., once a day, twice a day, once a week, etc.), taking time information (e.g., before or after meals), dosage, etc. This QR code (not shown) may be printed on each pouch of the manufactured IUD or on the IUD itself before delivery and may be scanned by the mobile device 15 of the individual 12 to indicate that the mobile device 15 easily and conveniently displays the information stored in the QR code to the mobile device 15. The mobile device 15 is installed with an application that can scan and recognize the two-dimensional barcode of the QR code. The QR code allows the individual 12 to repeatedly retrieve the medication information and instructions for use of the IUD as long as the QR code is not damaged.

[0027] Figure 2A flow chart of a method for manufacturing a personalized IUD to deliver a prescribed amount of active substance to an individual 12 is shown. In step 41, it is determined whether a valid prescription has been made. If a valid prescription does not exist, biometric measurement data is obtained from the individual in step 42 and transmitted to the medical professional 20 in step 44 using, for example, a wearable and / or non-wearable biometric measurement module 14, 16 and / or a network-enabled control system 18. The biometric measurement data may alternatively be input by the individual 12 and / or observed by the medical professional 20. The prescription may be prepared by the medical professional 20 in step 46 based on the biometric information and, optionally, based on information obtained from the patient database 22 and / or the medical information database 24. Then, in step 47, the insurance membership and coverage (e.g., copayment, deductible, etc.) of the individual 12 may be verified and determined by the insurance provider 17. In addition to verifying the insurance membership / status of the individual 12, step 47 also allows the insurance provider 17 to process billing and / or claims once the medical professional 20 prepares the prescription. The prescription may then be transmitted, ideally electronically, to the IUD manufacturer 26 in step 48. The IUD is manufactured based on the active substance and dosage regimen in the prescription via the IUD manufacturing device 13 in step 50 and delivered to the individual in a film 28, tablet 30, capsule 32, injectable form 34, patch 36, and / or other dosage form 38 in step 52. If a valid prescription does exist as determined in step 41, the process continues to step 48. After step 52, the process returns to step 41 to again determine if a valid prescription exists.

[0028] In another embodiment of the present invention, Figure 4 A prescription fulfillment system 11 is shown that is capable of collecting, analyzing and processing information and data to assist in electronically creating a prescription and filling the prescription by manufacturing a personalized IUD according to the instructions of the prescription.

[0029] The following describes the embodiment with reference to the flowchart illustrations and / or block diagrams of the method, apparatus (system) and computer program product according to the embodiment of the present invention. It should be understood that each box of the flowchart illustration and / or block diagram and the combination of boxes in the flowchart illustration and / or block diagram can be implemented by computer program instructions.

[0030] Providing such computer program instructions to a "server", "device", "computing device", "general purpose computer", "computer device", "system" or "special purpose computing device" causes the machine to produce an executable program, so that when they are executed, they create means for implementing the functions / actions specified in one or more blocks of the flowchart and / or block diagram. These computer program instructions may also be stored in a computer-readable medium, which can direct a computing device or other programmable data processing apparatus to operate in a specific manner, so that the instructions stored in the computer-readable medium produce an article of manufacture, which includes instruction means for implementing the functions / actions specified in one or more blocks of the flowchart and / or block diagram.

[0031] Embodiments of the invention are not necessarily limited to any specific number, type, or configuration of processors, nor to any specific programming language, memory storage format, or memory storage media.

[0032] As used herein, "participant" refers to a patient 12, a medical professional 20, an insurance provider 17, or an IUD manufacturer 26. "Patient" generally refers to a prescription recipient; "medical professional" generally refers to an attending physician or other medical professional authorized to prescribe to multiple patients; "insurance provider" generally refers to an insurance benefit plan provider; and "IUD manufacturer" generally refers to a prescription drug manufacturer / provider.

[0033] The prescription fulfillment system 11 is designed and configured so that each participant involved in the process of writing a prescription, authorizing coverage, and manufacturing a personalized IUD according to the present invention (the patient 12, the medical professional 20, the insurance provider 17, and the IUD manufacturer 26) can access and utilize the prescription fulfillment system 11 to perform the necessary tasks to complete the process of electronically creating a prescription and filling the prescription by manufacturing a personalized IUD according to the instructions of the prescription.

[0034] The prescription execution system 11 utilizes both the biometric measurement information data obtained and collected from the patient 12 and the various medical and health-related information stored in the medical information database 24 to allow the medical professional 20 to electronically formulate and process the prescription, thereby allowing the IUD manufacturer 26 to accurately produce a personalized IUD based on the instructions of the prescription.

[0035] The prescription execution system 11 provides several benefits to the patient 12. More specifically, the prescription execution system 11 provides the patient 12 with an easy way to view and manage the patient's prescriptions and medications by providing a comprehensive list of the patient's medications, a comprehensive list of the patient's prescriptions, information related to each medication, information related to each prescription, medication instructions, the delivery status of the manufactured IUD, etc. The prescription execution system 11 also provides an IUD that is made and customized (personalized) specifically for the individual patient according to the prescription and delivered to the patient 12. In addition to the time and convenience aspects of the process and system 11 described in the present disclosure, personalized IUDs can also be manufactured to ensure a higher level of patient safety because the personalized IUD is made taking into account the patient's medical history.

[0036] The prescription execution system 11 also provides benefits to the medical professional 20. More specifically, the prescription execution system 11 provides a simple way for the medical professional 20 to formulate and issue prescriptions by utilizing multiple modules configured in the network-enabled control system 18 and comprehensive information stored in multiple databases. In addition, the prescription execution system 11 acts as a central repository where all electronic prescriptions are saved and stored, so that the medical professional 20 can easily retrieve multiple prescriptions or any specific prescription. Each of the multiple modules and each of the multiple databases will be discussed in more detail below.

[0037] Reference again Figure 4 , the prescription execution system 11 generally includes a network-enabled control system 18; a database management system 19, which is operably linked to the network-enabled control system 18; a front-end application 21; and an optional biometric measurement module 14, 16, which interfaces with the patient 12 and is operably linked to the network-enabled control system 18. The database management system 19 is configured to manage a plurality of databases, including but not limited to a user account database 23, a patient database 22, a medical information database 24, a prescription database 25, an insurance information database 27, and a reminder notification database 29. Although in Figure 4 In the illustrated embodiment, one database management system 19 is shown, but the prescription execution system 11 can be designed and configured to include more than one database management system. Therefore, alternatively, each of the plurality of databases 22, 23, 24, 25, 27, 29 can be separately managed by a separate database management system 19.

[0038] like Figure 3 and Figure 4As shown, the network-enabled control system 18 includes one or more processing devices 104 or computing processing units (CPUs) 104. The one or more CPUs 104 may include dedicated circuits that include operational capabilities to perform specified operations integrated therein, such as application-specific integrated circuits (ASICs) and / or microprocessors. The one or more CPUs 104 are configured to interface with multiple databases 22, 23, 24, 25, 27, 29 in a database management system 19. The CPUs 104 are operable to act on programs or instruction sets stored in the database management system 19. The execution of the programs or instruction sets configured in the database management system 19 causes one of the CPUs 104 to perform tasks, such as locating data, retrieving data, processing data, etc. In addition, the one or more CPUs 104 may execute multiple modules (biometric measurement processing module 31, prescription processing module 33, insurance processing module 35, and reminder notification processing module 37) configured in the network-enabled control system 18. A number of modules 31, 33, 35, 37 may be executed to collect, analyze and process information to help create a prescription and fill the prescription by manufacturing an IUD according to the instructions of the prescription.

[0039] The user account database 23 may be configured to store information associated with the participants 12, 17, 20, 26 of the prescription execution system 11. As described above, the participants of the prescription execution system 11 are all parties involved in prescribing and filling prescriptions, such as the patient 12, the medical professional 20, the insurance provider 17, and the IUD manufacturer 26. Non-limiting examples of such information stored in the user account database 23 are name, address, contact phone number, contact email address, and participant type. The participant type is an attribute (indicator) used to determine which parts of the prescription execution system 11 a participant may be allowed to access. For example, if the participant type is a patient, the patient may view and track prescriptions, but will be restricted from creating prescriptions. User account information may be provided by each participant via the front-end application 21.

[0040] The patient database 22 is configured to store information associated with the patient 12. Non-limiting examples of such information are the patient's demographic profile, biometric measurement information, the patient's medical history, and family medical history. The patient's demographic profile includes all information related to the patient 12, such as name, age, gender, address, telephone number, email address, etc. The medical history includes all relevant medical history of the patient 12, such as treating medical professional information, current prescriptions, allergies, past and current medical conditions, family medical history, etc. The information stored in the patient database 22 can be provided by the patient 12 and / or the treating medical professional 20 via the front-end application 21.

[0041] The insurance information database 27 is configured to store information associated with the insurance benefit plans of the insurance provider 17 and the patient 12. Non-limiting examples of such information are primary insurance provider name, primary insurance provider address, primary insurance plan, primary insurance group number, primary insurance copayment information, primary insurance deductible information, primary insurance contact phone number, primary insurance contact email, secondary insurance provider name, secondary insurance provider address, secondary insurance plan, secondary insurance group number, secondary insurance copayment information, secondary insurance deductible information, primary insurance contact phone number, and primary insurance contact email. The insurance information may be provided by the insurance provider 17 and / or the patient 12 via the front-end application 21.

[0042] The medical information database 24 is configured to store necessary information for the medical professional 20 to formulate a diagnosis, treatment, and / or prescription. Non-limiting examples of the information stored in the medical information database 24 are disease information, symptom information, and treatment information for various diseases.

[0043] Prescription database 25 is configured to store prescription information provided by medical professionals 20 and electronic prescriptions generated via prescription execution system 11. Non-limiting examples of information stored in prescription database 25 are drug name, dosage, amount, refill authorization, refill availability, and patient information.

[0044] The reminder notification database 29 is configured to store details associated with various reminder notifications that may be generated by the prescription fulfillment system 11 and sent to the various participants 12, 17, 20, 26. Non-limiting examples of information stored in the reminder notification database 27 are reminder send date, sender name, recipient name, reminder message, and user type.

[0045] The plurality of databases 22, 23, 24, 25, 27, 29 may be configured to have any database type, such as a relational database, a distributed database, an object database, an object-relational database, a NoSQL database, etc. Furthermore, two or more of the databases 22, 23, 24, 25, 27, 29 may be combined.

[0046] The database management system 19 may be any electronic non-transitory form configured to manage the plurality of databases 22, 23, 24, 25, 27, 29. The database management system 19 may reside on the same or different computing device as the CPU 104. The database management system 19 may include MySQL, MariaDB, PostgreSQL, SQLite, Microsoft SQL Server, Oracle, SAP HANA, dBASE, FoxPro, IBM DB2, LibreOffice Base, FileMaker Pro, Microsoft Access, and InterSystems Caché. All or part of the database management system 19 may be maintained by a third party and / or configured as a cloud storage device.

[0047] As described above, the prescription execution system 11 also includes a front-end application 21. The front-end application 21 can be installed on a participant's computing device 39 for viewing and managing data / information and communicating between the participants 12, 17, 20, 26 of the prescription execution system 11. Thus, the front-end application 19 can be configured to provide for outputting information to the participants 12, 17, 20, 26. More specifically, the front-end application 21 has a graphical user interface (GUI) configured to display on a display device; a printer-ready output; a display-ready output; and / or an auditory output. The front-end application 21 can be operably linked to the network-enabled control system 18 via a network, such as a global computer network 43 (e.g., the Internet).

[0048] The front-end application 21 may be implemented as a standalone application on both a web-based platform (online / internet web application) and a mobile-based platform (mobile application) such that the participants 12, 17, 20, 26 can access the standalone application via the internet using a computing device 39 including a display and input devices implemented in the display. Non-limiting examples of computing devices include a personal computer (laptop or desktop), a mobile phone (smartphone), a tablet computer, a personal digital assistant (PDA), or other similar device. The computer device will typically access the prescription fulfillment system 11 directly through an Internet Service Provider (ISP) or indirectly through another network interface.

[0049] As described above, the participants 12, 17, 20, 26 of the prescription execution system 11 are the patient 12, the medical professional 20, the insurance provider 17, and the IUD manufacturer 26. The prescription execution system 11 is designed and configured to determine the user type when the participant logs into the prescription execution system 11 using established authentication credentials (e.g., username and password). Once the user type is determined using a successful login, the prescription execution system 11 according to an embodiment of the present invention displays information / data related to the specific participant type and provides the necessary features for performing tasks. For example, all participants 12, 17, 20, 26 can view prescriptions associated with the patient 12, but prescriptions can only be processed and created by the medical professional 20 via the prescription execution system 11.

[0050] Reference Figure 5 , a process for electronically creating a prescription and filling the prescription by manufacturing an IUD according to the instructions of the prescription is described in a flow chart. The process includes the following steps: electronically creating a prescription based on information provided by a medical professional 20; determining whether to continue filling the prescription; verifying the patient's insurance plan and determining the coverage of the drug prescribed in the prescription based on the patient's insurance plan; manufacturing the IUD based on the prescription by the IUD manufacturer 26; and delivering the manufactured IUD to the patient 12. All of these steps will be performed using the prescription execution system 11 according to the present invention. These steps will be described in more detail below.

[0051] The medical professional 20 may utilize the prescription execution system 11 to create, manage, and track prescriptions for multiple patients, and to communicate data and information (e.g., prescriptions) with other participants of the prescription execution system 11. For example, once the medical professional 20 is authenticated and logged into the prescription execution system 11 via the front-end application 21, the medical professional 20 may access the prescription generation page 49 to manage (view, update, and / or delete) any previously created prescriptions stored in the prescription execution system 11.

[0052] Additionally, in step 56, the medical professional 20 may electronically prescribe and electronically create a prescription for the patient 12 via the prescription generation page 49. However, before prescribing the medication, the medical professional 20 may need to review information related to the patient 12 stored in the plurality of databases 22, 23, 24, 25, 27, 29. In order to conveniently provide and retrieve information associated with the patient 12, a patient search feature is provided on the prescription generation page 49 for the medical professional 20 to initiate a patient search to retrieve all information related to the patient 12 before electronically prescribing the medication. Non-limiting examples of patient-specific information are demographic information of the patient (e.g., name, age, gender, date of birth, address, etc.); medical history, including current medical conditions (e.g., existing symptoms, allergies, and diseases); comprehensive biometric measurement information collected from the patient 12 and processed by the biometric measurement processing module 31, including DNA information; prescription history; and family medical history.

[0053] Once the patient search is complete, a selectable list of drugs and patient-specific information may also be provided. The drugs included in the drug list are retrieved based on the patient's current medical condition, the biometric information obtained and collected from the patient 12, and the information related to the biometric information in the medical information database 24, which may be effective in treating the patient 12. The medical professional 20 may then browse the drug list and select / deselect one or more drugs that may be most effective in treating the patient 12.

[0054] The prescription generation page 49 also provides input fields and / or drop-down lists for the medical professional 20 to manually enter and / or select any information necessary for the IUD manufacturer 26 to fill the prescription (such as dosage rate and amount of each selected medication), refill authorization, refill availability, etc. In addition, the medical professional 20 can manually enter medication instructions for the patient 12 (e.g., dosage, frequency, pre / post-meal instructions, etc.), which can be retrieved via the mobile device 15 to guide the patient 12 before taking the medication as described above in conjunction with the system 10 for making a personalized IUD.

[0055] Alternatively, if the medical professional 20 believes that the drug list does not include the most effective drug to treat the patient 12 , the medical professional 20 may provide one or more drugs by manually typing the drug name or some other drug identifier on the prescription generation page 49 .

[0056] The IUD manufacturer may be determined and assigned depending on whether the drug selected / input by the medical professional 20 is a brand name drug or a generic drug. If it is determined that the selected / input drug is a brand name drug, the manufacturer of the selected / input brand name drug may be automatically assigned via the prescription processing module 33 to make a personalized IUD based on the instructions of the prescription. Conversely, if it is determined that the selected / input drug is a generic drug, the medical professional 20 may assign an IUD manufacturer that is most suitable for producing the selected / input generic drug.

[0057] Once the medical professional 20 has selected and entered all of the information necessary to electronically generate a prescription and before submitting the information to the prescription execution system 11 via the front-end application 21, the prescription execution system 11 may verify the prescription information provided by the medical professional 20. Specifically, the prescription processing module 33 is utilized to determine whether the medical professional 20 has provided all of the necessary prescription information, and whether the medical professional 20 has correctly selected and entered all of the prescription information.

[0058] If all prescription information provided by the medical professional 20 is error-free and verified by the prescription processing module 33, the information is transmitted and processed for storage in the prescription database 25 in the database management system 19. The prescription may then be generated electronically via the prescription processing module 33 of the network-enabled control system 18 and may be displayed via the front-end application 21 upon request.

[0059] In step 58, once the prescription fulfillment system 11 electronically creates the new prescription, a new prescription reminder notification may be automatically generated and transmitted to the patient 12 via the reminder notification module 37 of the network-enabled control system 18. The new prescription reminder notification informs the patient 12 that a new prescription has been created and is ready for the patient 12 to review.

[0060] The patient 12 can log into the prescription execution system 11 via the front-end application 21 to access the patient page 51 to conveniently view and track all patient prescriptions and medications. Specifically, the patient page 51 displays a comprehensive selectable list of patient prescriptions, including new or unexecuted prescriptions; a comprehensive selectable list of patient medications; and the delivery status of all manufactured personalized IUDs of the patient 12. The patient page 51 may include a search feature that allows the patient 12 to search the medication list by medication attributes (such as current medications, past medications, IUD manufacturers, specific medications, etc.). Once the patient 12 has narrowed down the medication list, the patient 12 can browse and select a specific medication to retrieve medication information and medication instructions provided by the medical professional 20. This is an alternative to the QR code method described above in conjunction with the system 10 for making a personalized individual unit dose (IUD) for the patient 12 to view the medication instructions before taking the personalized IUD.

[0061] The patient page 51 can also be used to search the patient prescription list to display prescriptions by prescription attributes (such as unfilled prescriptions, filled prescriptions, prescriptions issued by medical professionals 20, specific prescriptions, etc.). Therefore, in order for the patient 12 to view the reminded new prescriptions, the patient 12 can search the prescription list to display only the unfilled prescriptions.

[0062] The patient page 51 may also include a status indicator for each prescription displayed on the page 51, which allows the patient 12 to update the status of each prescription. For example, depending on the patient's 12 actions on the patient page 51, the status of the prescription may be updated to "start viewing", "continue filling" or "not filling".

[0063] In step 60, the patient 12 may view the reminded new prescription via the front-end application 21 and decide whether to proceed with filling the reminded new prescription. If the patient 12 decides not to proceed with the prescription, in step 62, a no-fill prescription reminder notification may be automatically generated and transmitted to the medical professional 20 via the reminder notification module 37, thereby notifying the patient 12 that the patient 12 has decided not to proceed with filling the reminded new prescription.

[0064] If the patient 12 decides to proceed with filling the reminded new prescription, then in step 64, an IUD manufacturing process reminder notification may be automatically generated and transmitted to the IUD manufacturer 26 via the reminder notification module 37 to initiate production of a personalized IUD based on the reminded new prescription.

[0065] Meanwhile, in step 66 , the prescription execution system 11 may determine via the insurance processing module 35 whether the patient 12 participates in the insurance benefit plan provided by the insurance provider 17 based on the information stored in the insurance information database 27 of the database management system 19 .

[0066] If the insurance processing module 35 determines that the patient 12 does not participate in the insurance benefit plan, then in step 68, a no insurance reminder notice can be automatically generated and transmitted via the reminder notification module 37 to notify the IUD manufacturer 26 that the patient 12 does not have an insurance plan. Moreover, the no insurance reminder notice can instruct the IUD manufacturer 26 to process the invoice and send the invoice directly to the patient 12.

[0067] When the insurance processing module 35 determines that the patient 12 is enrolled in an insurance benefit plan, in step 70, an insurance reminder notification can be automatically generated and transmitted via the reminder notification module 37 to instruct the insurance provider 17 to initiate the process of verifying the insurance plan and determining the coverage of the drugs specified in the reminded new prescription based on the patient's insurance plan.

[0068] Using the patient page 51, the patient 12 can also easily manage existing prescriptions that need to be refilled. As described above, when the patient 12 selects a prescription, the prescription details including refill authorization and refill validity are retrieved and displayed on the patient page 51. Therefore, if the selected prescription is authorized for refill and refill is available, the patient 12 can simply transmit a refill reminder notification to the IUD manufacturer 26 via the reminder notification module 37 to create a personalized IUD based on the instructions of the prescription. However, if the prescription is neither authorized for refill nor refill is available, the patient 12 can transmit a refill request reminder notification to the medical professional 20 via the reminder notification module 37 to request a new prescription. In this case, the medical professional 20 can simply process the new prescription via the prescription execution system 11, or can require the patient to transmit current biometric measurement information via the wearable and / or non-wearable biometric measurement module 14, 16 and / or request the patient to visit the medical professional's office to assess the patient's current medical condition before processing the new prescription.

[0069] Insurance provider 17 may log into prescription fulfillment system 11 via front-end application 21 and access patient prescriptions page 53 to view and track all prescriptions for patients enrolled in the insurance benefit plan offered by insurance provider 17 .

[0070] Specifically, the patient prescriptions page 53 can display a comprehensive selectable list of the patient's prescriptions, including new or unfilled prescriptions. Similar to the patient page 51, the patient prescriptions page 53 includes a search feature that allows the insurance provider 17 to narrow the list and display prescriptions by prescription attributes (such as new prescriptions, filled prescriptions, prescriptions issued by medical professionals 20, prescriptions for patients 12, specific prescriptions, etc.). Therefore, in order for the insurance provider 17 to determine the coverage of the drugs specified in the alerted new prescriptions of the patient 12, the insurance provider 17 can filter the prescription list to include only new prescriptions.

[0071] When the insurance provider 17 selects one of the new prescriptions from the filtered list, patient-specific information, insurance information, and prescription information related to the selected prescription are displayed. Non-limiting examples of the patient-specific information, insurance information, and prescription information are the patient's name, address, insurance provider name, insurance plan, drug name, and refill authorization.

[0072] Then, in step 72, the insurance provider 17 may compare the drug costs with the terms of the patient's insurance benefit plan and coverage, and prepare a preliminary amount report via the insurance processing module 35, which includes the amount owed by the patient (e.g., deductible and co-payment, if applicable) and the amount for which the insurance provider 17 assumes financial responsibility. An insurance coverage reminder notification is then generated in step 74 and transmitted to the patient 12 via the reminder notification module 37 of the network-enabled control system 18, thereby notifying that the preliminary amount report is saved and stored in the prescription execution system 11 for the patient 12 to view via the front-end application 21.

[0073] The patient prescription page 53 may also include a status indicator for each prescription displayed on the page 53, which allows the insurance provider 17 to update the status of the prescription. For example, depending on the activity of the insurance provider 17 on the patient prescription page 53, the status of the prescription may be updated to "Insurance Coverage Analysis Started", "Insurance Coverage Analysis Completed", "Preliminary Amount Report Started", or "Preliminary Amount Report Started".

[0074] The IUD manufacturer 26 can also log into the prescription execution system 11 via the front-end application 21 and access the prescription execution page 55 to view and manage (update) all prescriptions assigned to the IUD manufacturer 26. Specifically, the prescription execution page 55 displays a comprehensive selectable list of all assigned prescriptions, including new prescriptions or unexecuted prescriptions stored in the prescription execution system 11. Similar to the patient page 51 and the patient prescription page 53, the prescription execution page includes a search feature that allows the IUD manufacturer 26 to narrow the list by prescription attributes (such as executed prescriptions, unexecuted prescriptions, prescriptions issued by medical professionals 20, prescriptions for patients 12, etc.), so that in order to manufacture a personalized IUD and fill the reminded new prescription, the IUD manufacturer 26 can filter the list of assigned prescriptions to display only unexecuted prescriptions.

[0075] When the IUD manufacturer 26 selects the alerted new prescription from the filtered list, patient-specific information and prescription information related to the selected prescription are displayed so that the IUD manufacturer 26 can manufacture an IUD according to the instructions of the alerted new prescription. Non-limiting examples of the patient-specific information and prescription information are the patient's name, address, allergies, drug name, dosage and amount, and medication instructions provided by the medical professional 20.

[0076] After the IUD manufacturer 26 fills the reminded new prescription by manufacturing the personalized IUD, in step 76, the IUD manufacturer 26 proceeds to package the manufactured personalized IUD and verify that each manufacturing process has been correctly followed and performed, and then ships the packaged manufactured personalized IUD directly to the patient 12.

[0077] In step 78, a delivery reminder notification may be automatically generated and transmitted to the patient 12, the medical professional 20, and the insurance provider 26 via the reminder notification module 37 to notify of the shipment and expected arrival date of the personalized IUD.

[0078] For packaging and delivery, the prescription fulfillment system 11 may implement the same features and methods as described above in conjunction with the system 10 for making a personalized IUD.

[0079] The prescription execution page 55 may also include a status indicator for each prescription displayed on the page 55, which allows the IDU manufacturer 17 to update the status of the prescription. For example, depending on the activity on the prescription execution page 55, the status of the prescription may be updated to "Production Started", "Production Completed", "Packaging Started", "Packaging Completed", and "IUD Shipped".

[0080] Biometric measurements and devices

[0081] The system 10 for creating one or more personalized individual unit doses (IUDs) and the prescription execution system 11 can use a variety of measurement tools to provide the medical professional with the necessary information to formulate one or more of a diagnosis, treatment, regimen, and prescription. The network-enabled control system 18 uses a biometric measurement instrument to perform measurements according to instructions from a medical professional and transmits these measurements to the medical professional via a control network. For example, in one aspect of the present disclosure, the individual communicates remotely, for example, using a live video conference to allow the medical professional to assess the individual's current condition and perform a virtual examination. The medical professional can conduct an examination in a manner similar to an in-office exam, ask appropriate questions required for a medical diagnosis, and can instruct the patient to perform certain measurements using available equipment, such as using his or her own biometric module. The medical professional can request measurements input and sent via a computer device, measurements transmitted by direct observation of the medical professional, or measurements communicated verbally by the patient to the medical professional. Regardless of the means of receiving medical data from the patient, the medical professional is able to determine a diagnosis or at least make a medical finding sufficient to recommend a course of treatment, regimen, and / or one or more of appropriate prescriptions for prescribing an IUD.

[0082] The US Centers for Disease Control and Prevention defines biometric screening as the measurement of physical characteristics (such as height, weight, BMI, blood pressure, blood cholesterol, blood glucose, and aerobic fitness) that can be performed in a medical professional's office or outside of a hospital (e.g., at home or at work) and can be used as a stand-alone assessment or as part of a health assessment. The use of biometrics in the personalized system of the present invention is to allow for the simplification of the medical assessment process for individual patients and the rapid, efficient, and cost-effective production and delivery of prescribed IUDs directly to those in need. Such efficiencies further serve to reduce the overall cost of healthcare on a patient-to-patient basis, minimize inventory, and thereby minimize shelf life.

[0083] A network-enabled control system ideally includes a processor, memory storage, and executable instructions, such as Figure 3 As further shown. Optionally, the system includes one or more of a display device, an alphanumeric input device, a cursor control device, a drive unit, a machine-readable medium device, and a signal generating device. Although manual input of measurement data collected and / or measured using a biometric measurement device is also contemplated, the biometric measurement device is ideally but not necessarily interfaced with a processor to facilitate the transmission of biometric measurement results. Software programs and forms designed to provide templates for inputting data and information useful to medical professionals may also be included as part of the system.

[0084] The biometric measurement module may include invasive devices and / or non-invasive measurement devices, or a combination thereof. The biometric measurement module may include a device selected from the group consisting of: an acoustic instrument, a visual instrument, a tactile instrument, a chemical instrument, a biological instrument, an electrical instrument, a thermal instrument, and a combination thereof. The biometric measurement module may include a device selected from the group consisting of: a camera, a video oscilloscope, a lighting system, a colorimeter, a spirometer, a Holter monitor, a vital sign monitor, a signal monitor, a sensor, an ultrasound probe, a machine that measures electrical signals from the body, a blood chemistry instrument, a blood flow measurement device, a blood content measurement device, a thermal measurement device, and a combination thereof. The biometric measurement module may include a device selected from the group consisting of: an electroencephalogram (EEG) machine; an electrocardiogram (EKG) machine; an electromyogram (EMG) machine; an echocardiogram (ECG) machine; an atrial fibrillation device; a stethoscope; a pharyngoscope; a sinusoscope; an otoscope; a laparoscope; a dermatoscope; a blood gas measurement device; a multi-purpose camera; a retinal camera; an eye measurement device; an intraoral camera; an abdominal ultrasound device; a vascular ultrasound device; a transvaginal ultrasound device; a skin surface measurement device that measures one or more of temperature, blood flow, blood sugar, skin color, texture, blood lipid content, and blood cholesterol content; an accelerometer; a motion sensor, and combinations thereof.

[0085] Examples of biometric measuring instruments include, but are not limited to, acoustic instruments, visual instruments, tactile instruments, chemical instruments, biological instruments, electrical instruments, and combinations thereof. For example, useful biometric instruments include those selected from the group consisting of: cameras, video oscilloscopes, lighting systems, colorimeters, spirometers, Holter Holter monitors, vital sign monitors, signal monitors, sensors, ultrasound probes, machines that measure electrical signals from the body, blood chemistry instruments, blood flow measurement devices, blood content measurement devices, thermal measurement devices, and combinations thereof. More specifically, the equipment for measuring biometric characteristics can be selected from the following: electroencephalogram (EEG) machine; electrocardiogram (EKG) machine; heart rate monitor; electromyogram (EMG) machine; echocardiogram (ECG) machine; atrial fibrillation equipment; stethoscope; pharyngoscope; sinusoscope; otoscope; laparoscope; dermatoscope; blood gas measurement equipment; multi-purpose camera; retinal camera; eye measurement equipment; intraoral camera; abdominal ultrasound equipment; vascular ultrasound equipment; transvaginal ultrasound equipment; skin surface measurement equipment that measures one or more of temperature, blood flow, blood sugar, skin color, texture, blood lipid content, blood cholesterol content; accelerometer; motion sensor, and their combinations.

[0086] The biometric measurement module may also include a mobile device including one or more software applications that can be used to obtain biometric information, information for making a diagnosis, information for a medical assessment, information for assessing the effectiveness of treatment and / or changes in treatment required for the individual, or a combination thereof. Such mobile devices may include mobile phones, tablet computers, laptops, watches, or wearable devices. In some cases, the device may be an implant located on or in the body of the individual patient.

[0087] Ideally, the medical professional is able to read the results directly from the measuring instrument via video conferencing, but alternatively, the results may be communicated to the medical professional via the Internet, verbally, or by recording the results sent over the network. The virtual examination is ideally conducted in much the same manner as an in-office examination, and ideally results in a recommended course of treatment, regimen, or prescription communicated / provided to the patient. In the case of a prescription for a medicated IUD, the prescription is communicated, ideally electronically, to an IUD manufacturer, who then makes the IUD in accordance with the prescribed dosage form (e.g., film, tablet, capsule, solution, cream, patch, syrup, etc.) and the prescribed dose, which may be, for example, 1 mg, 2 mg, 5 mg, 10 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, 70 mg, 80 mg, 90 mg, 100 mg, 150 mg, 200 mg, 500 mg, 1000 mg, and various amounts in between or even higher, depending on a variety of factors including, but not limited to, the selected active substance, the patient's medical condition, the patient's medical history, and the prescribed regimen or treatment. For example, a prescription may require an IUD containing 10 mg of an oral film of a CNS drug or a tablet containing 500 mg of an analgesic drug. The manufacturer then makes a personalized prescription to order and delivers (sends) the personalized prescription to the individual for whom the prescription was made. Alternatively, it may be delivered to an intermediary for quality checking or further distribution to individuals.

[0088] Manufacturing IUDs can be performed by any licensed manufacturer or drug compounder of active substances and dosage forms, or under the supervision of such a licensed manufacturer or drug compounder. However, unlike conventional systems, in which licensed pharmacists prepare compounded drugs based on prescriptions in pharmacies, according to the present invention, manufacturers can prepare personalized IUDs based on medical prescriptions and / or health information obtained via a network system, and then the personalized IUDs can all be delivered directly to patients through the disclosed system.

[0089] Manufacturing an IUD may include one or more of the following steps: providing a carrier matrix to one or more of the devices for making a personalized IUD; providing an active substance to one or more of the devices; combining the active substance and the carrier matrix in one or more of the devices; forming an IUD from the carrier matrix and the active substance; and packaging the IUD for distribution to an individual. Any packaging known in the art for use with a pharmaceutical product may be used herein.

[0090] Dosage form

[0091] Any dosage form can be used in the present disclosure. For example, useful non-limiting dosage forms include oral films (including instant film products), wafers, capsules, tablets, suspensions, solutions, ointments, patches, creams, gels, lozenges, ampoules, medicine bottles, syrups, tinctures, spirits, lozenges, balms, liniments, injections, and combinations thereof. Currently, as required by various world regulatory agencies, the change in the amount of active substance present in the dosage form must not exceed a specific percentage of the desired amount (labeled amount). When applied to dosage units based on the dosage form described herein, this actually requires that the active substance in the dosage form has uniformity compared to the labeled amount (i.e., desired amount).

[0092] These dosage forms used in the present disclosure can be made by any means known in the art. Examples of methods for making capsules useful herein are described in U.S. Patent Nos. 5,795,590 and 4,738,817, which are incorporated herein in their entirety. Examples of methods for making tablets that can be used in the present invention are described in U.S. Patent Nos. 5,213,738, 5,456,920, and 5,437,872, the contents of each of which are incorporated herein in their entirety. Further descriptions of useful methods for making tablets are described in "Pharmaceutical Dosage Forms: Tablets Volume 1," edited by Herbert A. Lieberman and Leon Lachman, Marcel Dekker, Inc, 1980, the contents of which are fully incorporated herein by reference.

[0093] Film

[0094] In the case of oral film dosage forms, agglomerates should be avoided because agglomerates tend to randomly distribute film components and any active substances present. When it comes to large doses, small changes in film size will result in large differences in the amount of active substances per film. If such film is to include low-dose active substances, it is possible that each part of the film may be substantially free of any active substance. Since the film is usually cut into unit doses, some doses may not contain active substances or contain insufficient active substances for recommended treatment. Failure to achieve high precision about the amount of the active ingredient in the film cut may be harmful to the patient. For this reason, a dosage form is formed by conventional methods (such as the method described in U.S. Patent No. 4,136,145 ("Fuchs") of Fuchs et al.). Fuchs will be unlikely to meet the strict standards related to the percentage of active substances of the government or regulatory agencies (such as the Federal Drug Administration ("FDA")), which can change in the dosage form compared with the labeled amount of the active substance.

[0095] Oral films for use in the present disclosure may be made by any means known in the art. Examples of methods for making oral films (including methods useful herein for describing uniformity of active substance content, preparing appropriate doses, and optimizing film processing, packaging, and administering IUDs) are described in U.S. Pat. Nos. 7,425,292; 7,357,891; 7,666,337; 8,017,150; 8,603,514; 8,765,167; 8,906,277; 8,900 497; 9,855,221; 9,931,305; 8,393,255 (bag cutter); 8,298,583 and 8,663,696 (tetrahydrolipstatin film); U.S. Patent Application Publication No. 2012 / 0107402A1 (method for analyzing and determining the size of a dose in an ingestible film); U.S. Patent No. 8,282,954 (making a film using a slurry without a water-based component, i.e., only having an organic solvent); U.S. Patent No. 9,095,577 (stable amine system); U.S. Patent No. 9,095,495 (apparatus for administering an effective dose); U.S. Patent No. 8,577,48 Nos. 8,936,825 and 9,561,191 (forming films directly onto packaging); U.S. Pat. No. 8,974,826 (nanoparticle film delivery system); U.S. Pat. Nos. 8,790,704 and 9,474,687 (peptide nanoparticle films); U.S. Pat. Nos. 9,346,601 and 9,771,173 (reducing stress cracking of films); U.S. Pat. Nos. 8,241,661 and 8,617,589 (biocompatible films with variable cross-sectional properties), all of which are assigned to Aquestive, Inc. (formerly MonoSol Rx, LLC), all of which are incorporated herein in their entirety.

[0096] Content uniformity

[0097] Each IUD must meet content uniformity requirements, which ensure that a defined amount of active substance is present in each IUD. The IUD is labeled with a specific required amount of active substance in each IUD. The IUD is manufactured so that the content of active substance contained in the finished IUD will vary by no more than 10% of the required amount. For example, if the required amount of active substance in the IUD (labeled amount) is 100 mg, the amount of active substance in the IUD may vary from 90 mg to 110 mg, but ideally not outside this range.

[0098] Individual health information

[0099] As discussed herein, the present invention includes the use of devices for measuring biometric information of an individual. This information can be viewed by or transmitted directly to a medical professional, or alternatively can be stored in a networked control system and accessed at a later time by a medical professional or patient. Additionally, the networked system can be configured to link to and / or transmit data with one or more third-party information databases containing patient information, information related to diagnosis, disease status, previous patient history, treatment regimens for disease or medical conditions, and IUD manufacturers.

[0100] When customizing the IUD for each individual patient, the personalized system can specifically take into account various backgrounds such as computational biology, bioinformatics, computer science, biology, pharmacology, medicine, and biomedical engineering.

[0101] The prescription drug monitoring program (PDMP) is an electronic database that tracks prescriptions for controlled drugs in a state. PDMP can provide timely information about prescriptions and patient behavior to health authorities, which contributes to the epidemic of prescription drugs and promotes targeted responses. PDMP is one of the most promising tools that can be used to address the improper use and abuse of prescription opioids. PDMP operates in every state (except Missouri) to collect data from pharmacies on controlled prescription drugs distributed to patients. Whenever a prescription is filled for controlled drug medication, the pharmacist (and some dispensing physicians) will report to the PDMP. If available at the bedside test (point of care), information from the PDMP can provide the prescriber or pharmacist with important information about the patient's history of using prescription drugs. Providers are more likely to be able to distinguish between patients who legitimately need opioid treatment and patients who may seek to improperly use the drug. If there are signs of improper use or abuse, reviewing PDMP data before prescribing also provides an opportunity for early intervention. In addition, licensing and regulatory boards can use PDMP data to determine abnormal prescribing patterns of prescribers.

[0102] Thus, the system or method of the present disclosure may optionally employ a review of PDMP data prior to determining a medical prescription and making an IUD. The system or method may also include the step of providing and / or storing information (i.e., data) related to an individual's health history, including personalized information about safety, efficacy, side effects, and frequency of use of active substances. Because the system disclosed herein already involves a networked system, this additional review can be a seamless and smooth part of the operation.

[0103] Membrane IUD

[0104] In one embodiment, the personalized IUD is a film. The film can be any known film in the art for delivering pharmaceutically active substances.

[0105] In one aspect, the film is a fast dissolving formulation for drug delivery, whereby the active agent is a coated particle through taste masking or controlled release. In the film dosage form, the taste masked medicament is ideally evenly distributed throughout the large film sheet, which is then cut into IUDs. The film roll made for the present invention can be divided into individual unit doses of equal size, and the individual unit doses have substantially equal amounts of each active component present. This advantage is particularly useful because it allows the large area film to be formed first, and then cut into individual unit doses, without having to worry about whether each unit contains a substantially uniform content of active drug film dosage forms. Drug film dosage forms have only recently been listed, mainly because the uniformity of drug content cannot be achieved in large area films and in IUDs cut from large area films. Therefore, for example, the film of the present disclosure has a special applicability as a drug dosage delivery system, because each individual unit dose of the film will contain an appropriate predetermined amount of drug, and the change of the appropriate predetermined amount relative to the required amount (i.e., the labeled amount) will not exceed 10%.

[0106] In another aspect of the present invention, a method for forming the film of the present invention by wet casting and hot melt extrusion is provided. In the wet casting, a polymer and a polar solvent are combined, the combination is formed into a film, and the film is dried in a controlled manner to form a film product. Preferably, in order to maintain non-self-aggregated uniform heterogeneity, heat is first applied only to the bottom side of the film to dry the film. Ideally, during the initial bottom drying stage, convection flow (i.e., hot air flow) is not allowed to pass through the top of the film until the viscoelastic properties of the film make the film components "locked" in place and unable to move, causing unevenness. At that stage, other heating methods can be used for drying.

[0107] Film can be formed with polar solvent, and described polar solvent can be water, polar organic solvent or their combination.Active component can be added in the combination of polymer and water before drying step.Alternately or as the supplement of the drying of control film, polymer can be selected to provide viscosity, and this viscosity keeps non-self-aggregation uniform heterogeneity.In addition, ideally by composition so that air is mixed in the mixture in a minimized manner, and ideally such as by regulating at room temperature, vacuum treatment etc. described composition is degassed so that trapped air escapes before drying process.This is used to eliminate the bubble and gap formation in the final film product, thereby further improves uniformity.Reverse roll coating is a kind of particularly useful coating technique, also can be used to form film.

[0108] Another embodiment of the present invention may include a fast dissolving film product, the fast dissolving film product contains at least one water-soluble polymer, the at least one water-soluble polymer includes polyethylene oxide alone or in combination with a hydrophilic cellulose polymer, wherein the film product may be free of added plasticizers. Preferably, the fast dissolving film product comprises at least one water-soluble polymer, the at least one water-soluble polymer contains about 20% to 100% by weight of polyethylene oxide, about 0% to 80% by weight of hydroxypropyl methylcellulose and about 0% to 80% by weight of hydroxypropyl cellulose; active ingredients; sweeteners; at least one flavoring; at least one coloring agent, wherein the film product is optionally free of added plasticizers, surfactants and polyols.

[0109] In another aspect of the present invention, a film using polyethylene oxide as a film-forming polymer can be formed by a hot melt extrusion process, thereby providing an edible film-forming polymer, and adding active ingredients during manufacture, and the mixture is blended at high temperatures without an additional solvent to form a uniform matrix, and extruded to form a film. Ideally, the film will be further formed to a specified thickness by a roller, and cooled and hardened to form a self-supporting film. The particularly desirable film-forming polymer for extrusion manufacturing is polyethylene oxide, which is heated to about 65°C to about 80°C during blending to provide a soft uniform matrix. Extrusion can be completed with a single screw extruder or other suitable extruders.

[0110] A particular advantage of the above extrusion process when used with microparticle coated active ingredients is that the absence of additional solvents during the manufacturing process reduces the likelihood of dissolution or release of the taste masked or controlled release coated active agent due to dissolution or solvent effects during manufacturing.

[0111] Another aspect of the present invention provides a film containing coated particles, the coated particles comprising an active agent and a taste-masking and / or controlled release coating. Therefore, a drug delivery composition is provided, the drug delivery composition comprising (i) a flowable water-soluble film-forming matrix; and (ii) a microparticle bio-effect agent uniformly placed in the film-forming matrix; and (iii) a taste-masking agent or a controlled release agent coated with microparticles or tightly combined with microparticles to provide taste-masking of the bio-effect agent. In some embodiments, the particle size of the combination of microparticles and taste-masking agents is 200 microns or less, and the flowable water-soluble film-forming matrix can be dried without losing the uniformity of the placement of the microparticle bio-effect agent therein.

[0112] In some embodiments, the taste masked or controlled release coated particles may have a particle size of 50 microns to 250 microns, and the flowable water soluble film-forming matrix is ​​capable of being dried without loss of uniformity of placement of the microparticulate bio-effecting agent therein. The importance of particle size is heightened in orally ingestible films, where uniformity is also particularly important, and the prior art fails to recognize such a critical feature.

[0113] Ideally, the size of the combination of microparticles and taste masking agents has a particle size of 150 microns or less, or 100 microns or less. The flowable water-soluble film-forming matrix can be formed into a dry film with a thickness of less than about 380 microns, for example, a thickness of less than about 250 microns. Ideally, the coated particles are completely embedded in the final film. In other words, the dry film of the present invention ideally has a smooth surface without exposed medicaments or coated particles, which can give the active substance sandiness or uneven distribution. Therefore, in one aspect of the present invention, a film carrier is provided, which contains a uniform distribution of active substances as defined herein, and is suitably free of particles accumulated on the film surface when dried.

[0114] Ideally, the taste masking agent or controlled release agent is a film coated on each part of the bioeffect agent. Useful taste masking agents include polymeric materials. Water-soluble polymers are also useful. Ideally, the mean molecular weight of the water-soluble polymer is equal to or greater than about 40,000. In addition, the water-soluble polymer can be an acrylic polymer, a cellulose polymer, and a combination thereof. In addition, vinyl polymers, crown ethers, hydrogenated oils and waxes and a combination thereof can also be used as taste masking agents.

[0115] In some embodiments described herein, the thin film drug delivery composition comprises: (a) an edible water-soluble film-forming matrix; and (b) a coated particulate active component uniformly placed in the film-forming matrix, wherein the coating on the particulate active component is a taste masking agent or a controlled release agent, and wherein the coated particulate active component has a particle size of 50 microns to 250 microns and is uniformly distributed in the film composition.

[0116] In some other embodiments, a thin film drug delivery composition is provided, comprising: (a) an edible water-soluble film-forming matrix comprising at least one water-soluble polymer comprising polyethylene oxide alone or in combination with a hydrophilic cellulosic polymer; and (b) a coated particulate active component uniformly placed in the film-forming matrix, wherein the coating on the particulate active component is a taste masking agent and / or a controlled release agent, and wherein the active component is uniformly distributed in the film composition.

[0117] Polymers that can be used to make IUDs

[0118] The polymer that can be used to make IUD can use polar solvents (such as water or alcohols) to soften or dissolve the polymeric material during the manufacturing process. Preferably, the polymer will be water-soluble. As used herein, the phrase "water-soluble polymer" and its variants refer to a polymer that is at least partially soluble in water, and ideally completely or mainly soluble in water or absorbs water. Polymers that absorb water are generally referred to as water-swellable polymers. The materials that can be used in the present invention can be water-soluble or water-swellable at room temperature and other temperatures (such as temperatures exceeding room temperature). Moreover, the material can be water-soluble or water-swellable at a pressure less than atmospheric pressure. Ideally, the water-soluble polymer is water-soluble or water-swellable, with a water absorption of at least 20% by weight. Water-swellable polymers with a water absorption of 25% by weight or more are also useful. The film or other dosage forms of the present invention formed by such water-soluble polymers are ideally fully water-soluble so as to be dissolveable when in contact with body fluids.

[0119] Other polymers that can be incorporated into the films or other dosage forms of the present invention include biodegradable polymers, copolymers, block polymers, and combinations thereof. One or more known useful polymer classes that meet the above criteria are: poly(glycolic acid) (PGA), poly(lactic acid) (PLA), polydioxanes, polyoxalates, poly(α-esters), polyanhydrides, polyacetates, polycaprolactones, poly(orthoesters), polyamino acids, polyaminocarbonates, polyurethanes, polycarbonates, polyamides, poly(alkyl cyanoacrylates), and mixtures and copolymers thereof. Additional useful polymers include stereopolymers of L-lactic acid and D-lactic acid, copolymers of bis(p-carboxyphenoxy)propane acid and sebacic acid, copolymers of sebacic acid, copolymers of caprolactone, poly(lactic acid) / poly(glycolic acid) / polyethylene glycol copolymers, copolymers of polyurethane and (poly(lactic acid), copolymers of polyurethane and (polylactic acid), copolymers of α-amino acids, copolymers of α-amino acids and caproic acid, copolymers of α-benzyl glutamate and polyethylene glycol, copolymers of succinate and poly(ethylene glycol), polyphosphazenes, polyhydroxyalkanoates, and mixtures thereof. Binary and ternary systems are contemplated.

[0120] Other useful specific polymers include those sold under the Medisorb and Biodel trademarks. Medisorb materials are sold by Dupont Company of Wilmington, Del., USA, and are generally identified as "lactide / glycolide copolymers" containing "2-hydroxy polymers of propionic acid and hydroxy polymers of glycolic acid." Four such polymers include: Lactide / glycolide 100L, believed to be 100% lactide with a melting point in the range of 338°F-347°F (170°C-175°C); Lactide / glycolide 100L, believed to be 100% glycolide with a melting point in the range of 437°F-455°F (225°C-235°C); Lactide / glycolide 85 / 15, believed to be 85% lactide and 15% glycolide with a melting point in the range of 338°F-347°F (170°C-175°C); and Lactide / glycolide 50 / 50, believed to be a copolymer of 50% lactide and 50% glycolide with a melting point in the range of 338°F-347°F (170°C-175°C).

[0121] Biodel materials represent a series of chemically different polyanhydrides. Although a variety of different polymers can be used, it is desirable to select the polymer to provide the desired mixture viscosity. For example, if the active substance or other components are not soluble in the selected solvent, a polymer that will provide a higher viscosity will be needed to help maintain homogeneity. On the other hand, if the components are soluble in the solvent, a polymer that provides a lower viscosity may be preferred.

[0122] Among the above-mentioned polymers, polyethylene oxide (PEO) is particularly suitable for hot melt extrusion process when used alone or in combination with hydrophilic cellulose polymers, and a flexible strong film is achieved. Additional plasticizers or polyols may be optionally included. Non-limiting examples of suitable cellulose polymers for combining with PEO include HPC and HPMC. PEO and HPC have substantially no gelling temperature, while the gelling temperature of HPMC is 58-64° C. (Methocel EF, commercially available from Dow Chemical Co.). In addition, these films are sufficiently flexible even when substantially free of organic solvents, and the film can be removed without damaging film properties. In this way, if there is no solvent, there is no plasticizer in the film. When the polymer component contains an appropriate level of PEO, the film based on PEO also exhibits good tear resistance, little or no curling, and a fast dissolution rate.

[0123] In order to realize required film properties, the level and / or molecular weight of PEO in the polymer component can be changed. Changing the PEO content can affect properties such as tear resistance, dissolution rate and adhesion tendency. Therefore, a method of controlling film properties is to change the PEO content. For example, in some embodiments, fast-dissolving film is desired. By changing the content of the polymer component, required dissolution characteristics can be realized.

[0124] According to the present invention, the PEO in the polymer component is desirably in the range of about 20 wt% to 100 wt%. In some embodiments, the amount of PEO is desirably in the range of about 1 mg to about 200 mg.

[0125] In some embodiments of the invention, a hydrophilic cellulosic polymer such as HPMC may also be used as the water soluble polymer at about 0 wt % to about 80 wt % or in a ratio up to about 4:1 with PEO and ideally about 1:1.

[0126] In some embodiments, it may be desirable to change the PEO level to promote certain film properties. In order to obtain a film with high tear resistance and fast dissolution rate, about 50% or higher PEO levels in the polymer component are ideal. In order to achieve prevention of adhesion, i.e., to prevent the film from adhering to the top of the oral cavity, it is desirable for the PEO level to be about 20% to 75%. However, in some embodiments, it may be desirable to adhere to the top of the oral cavity, such as for administration to animals or children. In such cases, a higher level of PEO can be adopted. More specifically, depending on the intended use, the structural integrity and dissolution of the film can be controlled so that the film can adhere to the mucous membrane and be easily removed, or can be more firmly adhered and difficult to remove.

[0127] The molecular weight of PEO can also vary. It may be desirable to have a high molecular weight (such as about 4 million) PEO to increase the mucoadhesion of the film. More ideally, the molecular weight may be in the range of about 100,000 to 900,000, more ideally about 100,000 to 600,000, and most ideally about 100,000 to 300,000. In some embodiments, it may be desirable to combine a high molecular weight (600,000 to 900,000) and a low molecular weight (100,000 to 300,000) PEO in the polymer component.

[0128] For example, certain film properties, such as fast dissolution rate and high tear resistance, can be obtained by combining a small amount of high molecular weight PEO with a large amount of lower molecular weight PEO. Ideally, such compositions contain about 60% or more of the lower molecular weight PEO in the PEO blend polymer component.

[0129] To balance the properties of anti-sticking, fast dissolution rate and good tear resistance, a desired film composition may comprise about 50% to 75% low molecular weight PEO, optionally combined with a small amount of higher molecular weight PEO, with the remainder being a polymer component containing a hydrophilic cellulosic polymer (HPC or HPMC).

[0130] Viscosity of fluid matrix and components

[0131] Polymer plays an important role in affecting the viscosity of dosage forms (such as suspensions, liquids, solutions and films). Viscosity is a characteristic of the stability of a liquid active substance in an emulsion, colloid or suspension. Typically, the viscosity of the matrix will be from about 400cps to about 100,000cps, preferably from about 800cps to about 60,000cps, and most preferably from about 1,000cps to about 40,000cps. When the dosage form is a film, ideally, the viscosity of the film-forming matrix will increase rapidly at the beginning of the drying process, and the viscosity is to ensure that the microparticles of the active substance are substantially "locked" in place and are therefore substantially uniformly placed in the matrix that carries them.

[0132] Can depend on other components in the matrix, based on the selected active substance, adjust the viscosity of the carrier matrix.Viscosity is particularly important for the active substance that is essentially particulate.For example, if the component is insoluble in the selected solvent, then suitable viscosity can be selected to prevent component sedimentation, and sedimentation will adversely affect the uniformity of the resulting film or liquid dosage form.Viscosity can be adjusted in different ways.In order to increase the viscosity of the film matrix, a polymer with a higher molecular weight can be selected or a cross-linking agent can be added, such as the salt of calcium, sodium and potassium.Viscosity can also be regulated by regulating the temperature or by adding a viscosity-increasing component.The component that will increase viscosity or stabilize emulsion / suspension includes a polymer, polysaccharide and gum of a higher molecular weight, and the polymer, polysaccharide and gum of the higher molecular weight include but are not limited to alginate, carrageenan, hydroxypropyl methylcellulose, locust bean gum, guar gum, xanthan gum, dextran, gum arabic, gellan gum, and their combination.

[0133] It has also been observed that certain polymers that normally require plasticizers to obtain a flexible film when used alone can be combined without the use of plasticizers and still obtain a flexible film. For example, HPMC and HPC, when used in combination, provide a flexible, strong film with appropriate plasticity and elasticity for manufacturing and storage. No additional plasticizers or polyols are required to achieve flexibility.

[0134] The carrier matrix can be any known inert component or mixture of components used in the formulation of a pharmaceutical composition. As will be readily appreciated by those of ordinary skill in the art, carrier matrices vary widely depending on the dosage form and desired end product. For example, the carrier matrix can be a formulation comprising a polymer, a solvent, an additive and / or a lubricant. It can include a powder, a liquid, or a combination thereof.

[0135] Polymers for Extruded Films

[0136] In an alternative embodiment of the invention, hot melt extrusion may be used to form the film.For the extrusion process, the polymer must be thermoplastic, meaning that the polymer can be melted in a suitable device, blended with other ingredients as required, and then extruded through an orifice under pressure to provide a film.

[0137] Active Agent

[0138] Suitable active substances for use in the self-supporting film agents of the present invention include, but are not limited to, the following therapeutic classes: angiotensin converting enzyme inhibitors; adrenergics; adrenocortical steroids; adrenocortical inhibitors; aldosterone antagonists; alkaloids; amino acids; anabolics; analeptics; analgesics; anesthetics; appetite suppressants; anti-acne agents; antiadreners; antiallergics; antiamoebics; antianemics; antianginals; antianxiety agents; antiarthritics; antiarrhythmics; antiasthmatics; antiatherosclerotics; anticholesterolemics; antibacterials; antibiotics; anticholinergics; anticoagulants; anticonvulsants; antidepressants; antidiabetics; antidiarrheals; antidiuretics; antidotes; antiemetics; antiepileptics; anti fibrinolytics; antifungals; antihemorrhagics; antihistamines; antihyperlipidemics; antihypertensives; antihypotensives; anti-infectives (systemic and non-systemic); anti-inflammatory agents; antilipids; antimanics; antimicrobials; antimigraines; antimitotics; antifungals, antinauseants; antineoplastics; antineutropenics; antiobesity agents; antiparasitics; antiparkinsonian agents; antiproliferatives; antipsychotics; antipyretics; antirheumatic agents; antiseborrheics; antisecretory agents; antispasmodics; antistroke agents; antithrombotic agents; antithyroid agents; antineoplastics; antitussives; antiulcers; antiuricemics; antivirals; appetite suppressants; appetite stimulants; biological response modifiers; blood glucose regulators; blood regulators; blood metabolism regulators ; bone resorption inhibitors; bronchodilators; cardiovascular drugs; central nervous system stimulants; brain dilators; contraceptives; coronary artery dilators; cholinergics; cough suppressants; decongestants; sedatives; diagnostic aids; dietary supplements; diuretics; dopaminergic agents; enzymes; estrogen receptor agonists; endometriosis control agents; expectorants; erectile dysfunction therapy; erythropoietic drugs; fibrinolytic drugs (ibrinolytic); fertility drugs; fluorescent agents; free oxygen radical scavengers; gastric acid inhibitors; gastrointestinal motility effectors; genetically modified drugs; glucocorticoids; hair growth stimulants; hemostatics; histamine H2 receptor antagonists; cisthenolytics; hormones; hypercalcemia management agents; hypocalcemia management agents; cholesterol-lowering drugs; Hypoglycemic agents; hypolipidemic agents; hypotensive agents; ion exchange resins; imaging agents; immunologic agents; immunomodulators; immunomodulators; immunostimulants; immunosuppressants; keratolytics; laxatives; LHRH agonists; mood regulators; motion sickness preparations; mucolytics; muscle relaxants; mydriatics; nasal decongestants; neuromuscular blocking agents; neuroprotectants; NMDA antagonists; non-hormonal sterol derivatives; osteoporosis therapeutics; oxytocics; parasympathetic blocking agents; parasympathomimetics; plasminogen activators; platelet activating factor antagonists; platelet aggregation inhibitors; prostaglandins; psychotherapeutic agents; psychotropic drugs; radiopharmaceuticals; respiratory agents; scabicides; sclerosants; tranquilizers; sedatives and hypnotics; selective adenosine A1 antagonists;Serotonin antagonists; serotonin inhibitors; serotonin receptor antagonists; smoking cessation therapy; steroids; stimulants; sympathetic nerve blockers; uterine relaxants; thyroid hormones; thyroid inhibitors; thyroxine mimetics; tranquilizers; tremor therapy; amyotrophic lateral sclerosis drugs; cerebral ischemic agents; Paget's disease agents; unstable angina drugs; vasoconstrictors; vasodilators; weight control drugs; wound healing agents; xanthine oxidase inhibitors; and combinations thereof.

[0139] Examples of pharmaceutically active substances suitable for use herein include antacids, H2 antagonists, and analgesics. For example, antacids can be prepared using the ingredient calcium carbonate alone or in combination with magnesium hydroxide and / or aluminum hydroxide. In addition, antacids can be used in combination with H2 antagonists.

[0140] Analgesics include opioids and opioid derivatives, such as oxycodone (available as Commercially available), ibuprofen (available as Motrin Motrin Advil Motrin Motrin Midol Cramp Motrin Migraine and Commercially available), aspirin (available as Genuine and commercially available), acetaminophen (available as Silapap Silapap Tylenol TylenolExtra Tylenol Infants' Tylenol Tylenol and commercially available), and combinations thereof, which may optionally include caffeine. Other pain relievers may also be used in the present invention, including meperidine hydrochloride (available as Commercially available), capsaicin (available as commercially available), morphine sulfate and naltrexone hydrochloride (available as Commercially available), hydromorphone hydrochloride (available as commercially available), propoxyphene naphthyl sulfonate, and acetaminophen (available as Commercially available), fentanyl (available as and Commercially available), sodium hyaluronate (available as Commercially available), adalimumab (available as Commercially available), sumatriptan succinate (available as Commercially available), fentanyl iontophoresis (available as Commercially available), o-phenhydramine citrate (available as Commercially available), magnesium salicylate tetrahydrate (available as Commercially available), oxymorphone hydrochloride (available as Opana Commercially available), methocarbamol (available as Commercially available), Carisoprodol (available as Commercially available), tramadol hydrochloride (available as and Commercially available), morphine sulfate (available as MS Commercially available), metaxalone (available as Commercially available), oxycodone hydrochloride (available as commercially available), acetaminophen / oxycodone hydrochloride (available as Commercially available), oxycodone / aspirin (available as Commercially available), hydrocodone tartrate / acetaminophen (available as Commercially available), hydrocodone tartrate / ibuprofen (available as Commercially available), nepafenac (available as commercially available) and pregabalin (available as Commercially available).

[0141] The self-supporting film dosage forms disclosed herein may also include agents such as NSAIDs, including etodolac (which may be used as Commercially available), ketorolac tromethamine (available as or Commercially available), naproxen sodium (available as Commercially available), flurbiprofen (available as Commercially available), diclofenac sodium / misoprostol (available as Commercially available), celecoxib (available as Commercially available), sulindac (available as Commercially available), oxaprozin ((available as Commercially available), piroxicam (available as Commercially available), indomethacin (available as Commercially available), meloxicam (available as Commercially available), mefenamic acid (available as Commercially available), Tolmetin sodium (available as Commercially available), choline magnesium trisalicylate (available as Commercially available), diclofenac sodium (available as Commercially available), diclofenac potassium (available as or commercially available) and misoprostol (available as Commercially available), opioid agonists and antagonists, such as buprenorphine and naloxone are other examples of pharmaceutical products useful in the present invention.

[0142] Other preferred drugs for other preferred active ingredients used herein include antidiarrheal drugs such as loperamide (available as Imodium QC Health Care America Leader and Commercially available), nitazoxanide (available as commercially available), and diphenoxylate hydrochloride / atropine sulfate (available as commercially available); antihistamines; antitussives; decongestants; vitamins; and breath fresheners; common remedies for colds, pain, fever, cough, congestion, runny nose, and allergies, such as acetaminophen, ibuprofen, chlorpheniramine maleate, dextromethorphan, dextromethorphan HBr, phenylephrine HCl, pseudoephedrine HCl, diphenhydramine, and combinations thereof, such as dextromethorphan HBr and phenylephrine HCl (available as Obtained), can be contained in the film composition of the present invention.

[0143] Other active agents useful herein include, but are not limited to, alcohol dependence treatments such as acamprosate calcium (available as commercially available); allergy treatments such as promethazine hydrochloride (available as Commercially available), bepotastine besilate (available as Commercially available), chlorpheniramine hydrocodone / chlorpheniramine-sulfonated divinylbenzene (available as Commercially available), cetirizine hydrochloride (available as Commercially available), cetirizine hydrochloride / pseudoephedrine hydrochloride (available as Commercially available), promethazine hydrochloride / codeine phosphate (available as commercially available with codeine), pemirolast (available as Commercially available), fexofenadine hydrochloride (available as Commercially available), meclizine hydrochloride (available as Commercially available), azelastine hydrochloride (available as Commercially available), Nizatidine (available as Commercially available), desloratadine (available as Commercially available), sodium cromoglycate (available as Commercially available), epinastine hydrochloride (available as Commercially available), azelastine hydrochloride (available as Commercially available), prednisolone sodium phosphate (available as Orapred Commercially available), Olopatadine hydrochloride (available as Commercially available), ketotifen fumarate (available as commercially available), and montelukast sodium (available as commercially available); and antihistamines, such as diphenhydramine hydrochloride (available as Commercially available), loratadine (available as Commercially available), astemizole (available as Commercially available), nabumetone (available as Commercially available), diphenhydramine hydrochloride ((available as Commercially available) and Cleaver (available as Commercially available).

[0144] Active substances used in the present disclosure may also include Alzheimer's disease therapeutic drugs, such as tacrine hydrochloride (available as Commercially available), galantamine (available as Commercially available), donepezil hydrochloride (available as Commercially available), rivastigmine tartrate (available as Commercially available), octyne (available as Commercially available) and memantine (available as commercially available); anemia drugs, such as cyanocobalamin (available as Commercially available) and nano-iron oxide (available as commercially available); anesthetics such as antipyrine and benzocaine (available as and angina drugs, such as amlodipine besylate (available as Commercially available), nitroglycerin (available as Commercially available), isosorbide mononitrate (available as commercially available) and isosorbide dinitrate (available as commercially available); analgesics such as guaifenesin; anti-Alzheimer's drugs such as nicergoline; and Ca HAntagonists such as nifedipine (available as and Commercially available).

[0145] Active substances useful in the present disclosure may also include anti-asthmatic drugs such as salbutamol sulfate (available as Commercially available), ipratropium bromide (available as Commercially available), salmeterol xinafoate (available as Commercially available), zafirlukast (available as Commercially available), flunisolide (available as Commercially available), orphenadrine sulfate (available as Commercially available), salbutamol inhaler (available as Commercially available), terbutaline sulfate (available as Commercially available), formoterol (available as Commercially available), sodium cromoglycate (available as Commercially available), salbutamol hydrochloride (available as Commercially available), Qiliutong (available as Commercially available), fluticasone propionate / salmeterol (available as Commercially available), salbutamol sulfate / triamcinolone acetonide (available as Commercially available), dimethylxanthine (available as commercially available), and beclomethasone (available as commercially available); angioedema drugs, such as C1 esterase inhibitor (human) (available as Commercially available) and ecallantide (available as commercially available); and antibacterial drugs, such as trimethoprim / sulfamethoxazole (available as Commercially available), mupirocin (available as Commercially available), metronidazole (available as commercially available), acesulfame-2-oxazole (available as commercially available), bismuth subsalicylate, and metronidazole / tetracycline hydrochloride (available as Helidac Commercially available), nitrofurantoin (available as Commercially available), norfloxacin (available as Commercially available), erythromycin ethylsuccinate / acetylsulfoxazole (available as Commercially available) and levofloxacin (available as Commercially available).

[0146] Other active ingredients may include one or more antibiotics, including amoxicillin (available as Commercially available), ampicillin (available as and Commercially available), amoxicillin / clavulanate potassium (available as Commercially available), moxifloxacin hydrochloride (available as Commercially available), besifloxacin (available as Commercially available), clarithromycin (available as Commercially available), ceftibuten (available as Commercially available), cefuroxime axetil (available as Commercially available), cefprozil (available as Commercially available), ciprofloxacin hydrochloride (available as and Commercially available), clindamycin phosphate (available as Cleocin Commercially available), doxycycline hydrochloride (available as Commercially available), dirithromycin (available as Commercially available), erythromycin (available as and Commercially available), topical erythromycin (available as Commercially available), Gemifloxacin (available as Commercially available), ofloxacin (commercially known as ), Telithromycin (can be used as Commercially available), lomefloxacin hydrochloride (available as Commercially available), minocycline hydrochloride (available as Commercially available), fosfomycin tromethamine (available as commercially available), penicillin and potassium (available as Penicillin Commercially available), trimethoprim (available as Commercially available), ciprofloxacin hydrochloride (available as Proquin commercially available), rifampicin, isoniazid, and pyrazinamide (available as Commercially available), Cefditoren (available as Commercially available), cefixime (available as Commercially available), tetracycline (available as Achromycin and Commercially available), tobramycin (available as Commercially available), rifaximin (available as Commercially available), azithromycin (available as Commercially available), azithromycin suspension (available as Commercially available), linezolid (available as commercially available), benzoyl peroxide, and clindamycin (available as commercially available), erythromycin, and benzoyl peroxide (available as Commercially available), dexamethasone (available as commercially available), ciprofloxacin, and dexamethasone (available as commercially available), polymyxin B sulfate / neomycin sulfate / hydrocortisone (available as commercially available), colistin sulfate / neomycin sulfate / hydrocortisone acetate / hexadecyldiamine bromide (available as Cortisporin-TC Commercially available), cephalexin hydrochloride (available as Commercially available), Cefdinir (available as Commercially available) and gatifloxacin (available as Commercially available).

[0147] Other useful active substances include cancer treatment drugs, including cyclophosphamide (available as Commercially available), methotrexate (available as and Commercially available), tamoxifen citrate (available as Commercially available), bevacizumab (available as Commercially available), everolimus (available as Commercially available), pazopanib (available as Commercially available), and anastrozole (available as commercially available); leukemia treatments such as ofatumumab (available as commercially available); antithrombotic drugs, such as antithrombin recombinant lyophilized powder (available as Commercially available), prasugrel (available as commercially available); anticoagulants, such as aspirin and delayed-release dipyridamole (available as Commercially available), warfarin sodium (available as Commercially available), dipyridamole (available as Commercially available), dalteparin (available as Commercially available), danaparin sodium (available as Commercially available), enoxaparin (available as commercially available), heparin (available as Hep-Lock, Hep-Pak, Hep-Pak CVC, Heparin Lock Flush), tinzaparin (available as commercially available) and clopidogrel bisulfate (available as commercially available); antiemetics, such as granisetron hydrochloride (available as Commercially available) and Nabilone (available as Commercially available), trimethobenzylamine hydrochloride (available as Commercially available) and ondansetron hydrochloride (available as commercially available); antifungal treatments such as ketoconazole (available as Commercially available), posaconazole (available as Commercially available), ciclopirox (available as Commercially available), griseofulvin (available as Commercially available), oxiconazole nitrate (available as Commercially available), fluconazole (available as Commercially available), sertaconazole nitrate (available as Commercially available), terbinafine hydrochloride (available as Commercially available), ciclopirox (available as commercially available), nystatin / triamcinolone acetonide (available as Commercially available), econazole nitrate (available as Commercially available), itraconazole (available as Commercially available) and terconazole (available as Commercially available).

[0148] Active agents may also include anti-inflammatory drugs, such as hydroxychloroquine sulfate (available as Commercially available), fluticasone propionate (available as Commercially available), Canakinumab (available as Commercially available), amcinonide (available as Commercially available), methylprednisolone (available as Commercially available), budesonide (available as Entocort Commercially available), anakinra (available as Commercially available), diflorasone acetate (available as commercially available), and etanercept (available as commercially available); anticonvulsants such as phenobarbital / hyoscyamine sulfate / atropine sulfate / scopolamine hydrobromide (available as Commercially available; antiviral therapeutics, such as oseltamivir phosphate (available as commercially available); antiparasitic drugs, including tinidazole (available as commercially available); appetite suppressants, such as megestrol acetate (available as Megace Commercially available), phentermine hydrochloride (available as Adipex- Commercially available) and diethylpropion hydrochloride (available as commercially available); arthritis drugs, including leflunomide (available as Commercially available), Certolizumab (available as Commercially available), diclofenac sodium (available as Commercially available), golimumab (available as Commercially available), and tocilizumab (available as commercially available); bladder control drugs, such as trospium chloride (available as Commercially available), desmopressin acetate (available as Commercially available), tolterodine tartrate (available as Commercially available), oxybutynin chloride (available as or Commercially available), darifenacin (available as Commercially available) and solifenacin succinate (available as commercially available); vasoconstrictors such as methylergonovine maleate (available as commercially available); plasma uric acid management agents, such as rasburicase (available as commercially available); iron deficiency anemia drugs, such as nano-iron oxide (available as commercially available); lymphoma drugs such as pralatrexate (available as Commercially available), romidepsin (available as commercially available); malaria drugs such as artemether / lumefantrine (available as commercially available); hyponatremia drugs, such as tolvaptan (available as commercially available); drugs used to treat von Willebrand disease (available as commercially available); antihypertensive drugs, such as treprostinil (available as Commercially available), tadalafil (available as commercially available); cholesterol-lowering drugs, including paricalcitol (available as Commercially available), pitavastatin (available as Commercially available), lovastatin, niacin (available as Commercially available), colestipol hydrochloride (available as Commercially available), rosuvastatin calcium (available as Commercially available), fluvastatin sodium (available as commercially available), atorvastatin calcium (available as Lovastatin (available as Commercially available), niacin (available as Commercially available), pravastatin sodium (available as commercially available), pravastatin sodium with buffered aspirin (available as Pravigard Commercially available), cholestyramine (available as commercially available), simvastatin, and niacin (available as Commercially available), atenolol, chlorthalidone (available as Commercially available), atenolol (available as Commercially available), fenofibrate (available as Commercially available), fenofibrate (available as Commercially available), ezetimibe / simvastatin (available as Commercially available), colesevelam (available as Commercially available), bisoprolol fumarate (available as Commercially available), ezetimibe (available as Commercially available), bisoprolol fumarate / hydrochlorothiazide (available as commercially available), and simvastatin (available as Commercially available).

[0149] Pharmaceutically active substances included herein may also include chronic kidney disease drugs, such as paricalcitol (available as commercially available); contraceptives, including etonogestrel (available as commercially available), norethindrone acetate, ethinyl estradiol (available as Loestrin 24 Commercially available), ethinyl estradiol, norgestrel (available as Ortho Commercially available), levonorgestrel (available as Plan commercially available), levonorgestrel and ethinyl estradiol (available as commercially available), levonorgestrel, ethinyl estradiol (available as commercially available) and medroxyprogesterone acetate (available as commercially available); COPD drugs such as arformoterol tartrate (available as Commercially available) and ipratropium bromide, salbutamol sulfate (available as commercially available); cough suppressants, including benzonatate (available as commercially available), guaifenesin, codeine phosphate (available as Tussi-Organidin commercially available) and acetaminophen, codeine phosphate (available as Tylenol and commercially available); drugs for the treatment of diabetes, including pioglitazone hydrochloride, metformin hydrochloride (available as ACTOplus Commercially available), bromocriptine mesylate (available as Commercially available), liraglutide (available as Commercially available), saxagliptin (available as Commercially available), pioglitazone hydrochloride (available as Commercially available), glimepiride (available as Commercially available), rosiglitazone maleate, metformin hydrochloride (available as Commercially available), rosiglitazone maleate (available as Commercially available), rosiglitazone maleate (available as Commercially available), Exenatide (available as Commercially available), Exenatide (available as Commercially available), chlorsulfuronamide (available as Commercially available), pioglitazone hydrochloride, glimepiride (available as Commercially available), metformin hydrochloride (available as Commercially available), glipizide (available as Commercially available), glibenclamide, metformin (available as and Commercially available), metformin hydrochloride (available as Commercially available), sitagliptin (available as Commercially available), insulin detemir (available as Commercially available), glipizide, metformin hydrochloride (available as Commercially available), glibenclamide (available as Commercially available), repaglinide (available as Commercially available), acarbose (available as Commercially available), nateglinide (available as Commercially available), Pramlintide acetate (available as Commercially available), canagliflozin (available as Commercially available), linagliptin (available as Commercially available), dapagliflozin (available as Commercially available), insulin glargine (available as or Commercially available), insulin aspart (available as Commercially available), insulin lispro, empagliflozin (available as Commercially available) and tolazamide (available as Commercially available).

[0150] Other useful active substances of the present invention may include digestive agents such as sulfasalazine (which may be used as Commercially available), rabeprazole sodium (available as Commercially available), lubiprostone (available as Commercially available), dicyclomine hydrochloride (available as Commercially available), sucralfate (available as Commercially available), lactulose (available as Commercially available), docusate (available as Commercially available), balsalazide disodium (available as Commercially available), losartan potassium (available as Commercially available), sodium azotocin (available as Commercially available), chlordiazepoxide hydrochloride, clarithromycin bromide (available as Commercially available), esomeprazole magnesium (available as Commercially available), famotidine (available as Commercially available), lansoprazole (available as commercially available), lansoprazole, and naproxen (available as Prevacid Commercially available), amoxicillin / clarithromycin / lansoprazole (available as Commercially available), omeprazole (available as Commercially available), pantoprazole sodium (available as Commercially available), metoclopramide hydrochloride (available as or Commercially available), cimetidine (available as Commercially available), ranitidine hydrochloride (available as commercially available), and omeprazole, sodium bicarbonate (available as commercially available); diuretics, including spironolactone, hydrochlorothiazide (available as Commercially available), spironolactone (available as Commercially available), bumetanide (available as Commercially available), torsemide (available as Commercially available), chlorothiazide (available as Commercially available), furosemide (available as Commercially available), metolazone (available as commercially available) and hydrochlorothiazide, triamterene (available as Commercially available).

[0151] Active agents useful in the present invention may also include drugs for treating emphysema, such as tiotropium bromide (available as commercially available); fibromyalgia drugs, such as milnacipran hydrochloride (available as commercially available); drugs used to treat gout, such as colchicine (commercially available as ) and febuxostat (commercially available as ); enema therapy, including aminosalicylic acid (can be used as and commercially available); epilepsy drugs, including valproic acid (available as Commercially available), felbamate (available as Commercially available), lamotrigine (available as Commercially available), primidone (available as Commercially available), oxcarbazepine (available as Commercially available), zonisamide (available as Commercially available), levetiracetam (available as Commercially available) and phenytoin sodium (available as Commercially available).

[0152] Erectile dysfunction therapies useful herein include, but are not limited to, drugs for promoting blood flow to the penis and for achieving autonomic nervous activity, such as drugs that increase parasympathetic (cholinergic) and decrease sympathetic (adrenergic) nerves. Useful agents for treating erectile dysfunction include, for example, those available as: alprostadil (available as Commercially available), tadalafil (available as Commercially available), vardenafil (available as Commercially available), apomorphine (available as Commercially available), Yohimbine Hydrochloride (available as commercially available) and sildenafil citrate (available as Commercially available).

[0153] Active substances useful herein may also include ophthalmic and therapeutic agents such as dipivefrin hydrochloride (available as Commercially available), valganciclovir (available as Commercially available), ganciclovir ophthalmic gel (available as Commercially available); Bepotastine besilate (available as Commercially available), besifloxacin (available as Commercially available), bromfenac (available as Commercially available), fluorometholone (available as Commercially available), pilocarpine hydrochloride (available as Commercially available), cyclosporine (available as Commercially available), brimonidine tartrate (available as Alphagan Commercially available), Dorzolamide hydrochloride / Timolol maleate (available as Commercially available), bimatoprost (available as Commercially available), timolol maleate (available as Commercially available), travoprost (available as Commercially available), latanoprost (available as Phospholine Commercially available), and ranibizumab (available as commercially available); flow control agents such as acetazolamide (available as commercially available); gallstone drugs, including ursodiol (available as commercially available); drugs used to treat gingivitis, including chlorhexidine gluconate (available as headache medications, including butalbital / codeine phosphate / aspirin / caffeine (available as and codeine), naratriptan hydrochloride (available as Commercially available), almotriptan (available as Commercially available), ergotamine tartrate / caffeine (available as commercially available), butalbital / acetaminophen / caffeine (available as commercially available), butalbital / aspirin / caffeine (available as purchased), forvatriptan succinate (available as Commercially available), rizatriptan benzoate (available as Commercially available), Isometheptene mucoside / chloralphenazone / acetaminophen (available as Commercially available), dihydroergoline mesylate (available as Commercially available), eletriptan hydrobromide (available as Commercially available) and zolmitriptan (available as commercially available); influenza drugs, such as Haemophilus influenzae b conjugate vaccine; tetanus toxoid conjugate (available as commercially available); and cardiac therapeutics, including quinidine sulfate, isosorbide dinitrate / hydralazine hydrochloride (available as Commercially available), digoxin (available as Commercially available), Flecainide acetate (available as Commercially available), mexiletine hydrochloride (available as Commercially available), disopyramide phosphate (available as Commercially available), procainamide hydrochloride (available as Commercially available) and propafenone (available as Commercially available).

[0154] Other useful active substances include hepatitis therapeutics, including entecavir (available as Commercially available), hepatitis B immune globulin (available as HepaGam commercially available), and ribavirin (copegus / rebetol / ribasphere / vilona / virazole) (available as commercially available); herpes treatments, including valacyclovir hydrochloride (available as Commercially available), penciclovir (available as Commercially available), acyclovir (available as commercially available), and famciclovir (available as commercially available); therapeutic agents for hypertension, including enalaprilat (available as Commercially available), captopril (available as Commercially available) and lisinopril (available as Commercially available), verapamil hydrochloride (available as Commercially available), Ramipril (available as Commercially available), Olmesartan Medoxomil (available as Commercially available), amlodipine / atorvastatin (available as Commercially available), nicardipine hydrochloride (available as Commercially available), diltiazem hydrochloride (available as Commercially available as ), quinapril hydrochloride (available as Commercially available), quinapril hydrochloride / hydrochlorothiazide (available as Commercially available), perindopril tert-butylamine salt (available as Commercially available), candesartan cilexetil (available as Commercially available), candesartan cilexetil / hydrochlorothiazide (available as Atacand Commercially available), irbesartan / hydrochlorothiazide (available as Commercially available), irbesartan (available as Commercially available), amlodipine besylate / olmesartan medoxomil (available as Commercially available), levobunolol hydrochloride (available as Commercially available), betaxolol hydrochloride (available as Commercially available), nebivolol (available as Commercially available), captopril / hydrochlorothiazide (available as Commercially available), doxazosin mesylate (available as Commercially available), clonidine hydrochloride (available as Commercially available), carvedilol (available as Commercially available), nadolol (available as Commercially available), nadolol / bendrofluazide (available as Commercially available), valsartan (available as Commercially available), isradipine (available as Commercially available), guanabenzyl acetate (available as Commercially available), guanfacine hydrochloride (available as or Commercially available), losartan potassium / hydrochlorothiazide (available as Commercially available), propranolol hydrochloride (available as Commercially available), propranolol hydrochloride / hydrochlorothiazide (available as Commercially available), eplerenone (available as Commercially available), ambrisentan (available as Commercially available), enalapril maleate / felodipine (available as Commercially available), metoprolol tartrate (available as Commercially available), benazepril hydrochloride (available as Commercially available), benazepril hydrochloride / hydrochlorothiazide (available as Lotensin Commercially available), amlodipine / benazepril hydrochloride (available as Commercially available), indapamide (available as Commercially available), trandolapril (available as commercially available), telmisartan (available as commercially available), telmisartan / hydrochlorothiazide (available as Micardis Commercially available), prazosin hydrochloride (available as Commercially available), amiloride, hydrochlorothiazide (available as Commercially available), fosinopril sodium (available as ZZXT commercially available), fosinopril sodium / hydrochlorothiazide (available as Commercially available), pindolol (available as Commercially available), felodipine (available as Commercially available), sildenafil citrate (available as Commercially available), nisoldipine (available as Commercially available), trandolapril / verapamil hydrochloride (available as Commercially available), aliskiren (available as Commercially available), eprosartan mesylate (available as Commercially available), eprosartan mesylate / hydrochlorothiazide (available as Teveten Commercially available), moexipril hydrochloride / hydrochlorothiazide (available as Commercially available), Moexipril hydrochloride (available as Commercially available), enalapril maleate / hydrochlorothiazide (available as commercially available) and lisinopril / hydrochlorothiazide (available as Commercially available).

[0155] Other active substances can be used in drugs for the treatment of HIV / AIDS, such as amprenavir (which can be used as Commercially available), Tipranavir (available as Commercially available), efavirenz / emtricitabine / tenofovir (available as commercially available), lamivudine / zidovudine (available as Commercially available), indinavir sulfate (available as Commercially available), lamivudine (available as Commercially available), saquinavir (available as Commercially available), zalcitabine (available as Commercially available), lopinavir / ritonavir (available as Commercially available), fosamprenavir calcium (available as Commercially available), ritonavir (available as Commercially available), zidovudine (available as Commercially available), atazanavir sulfate (available as Commercially available), efavirenz (available as Commercially available), abacavir / lamivudine / zidovudine (available as Commercially available), didanosine (available as Commercially available), nelfinavir mesylate (available as Commercially available), nevirapine (available as Commercially available), tenofovir disoproxil fumarate (available as Commercially available), stavudine (available as Commercially available) and abacavir sulfate (available as commercially available); homocysteine ​​removers, including anhydrous betaine (available as commercially available); drugs, such as insulin (available as and commercially available); and HPV therapeutics, such as human papillomavirus vaccines (available as Commercially available) or human bivalent papillomavirus (available as commercially available); immunosuppressants, including cyclosporine (available as and Commercially available).

[0156] Active substances useful in the present disclosure may also include prolactin inhibitors, such as bromocriptine mesylate (available as commercially available); drugs used to assist with stress testing, such as regadenoson (available as commercially available); hair loss drugs, including finasteride (available as and commercially available); pancreatitis therapeutics such as gemfibrozil (available as commercially available); hormonal drugs such as norethindrone acetate / ethinyl estradiol (available as Commercially available), goserelin acetate (available as Commercially available), progesterone gel (available as Commercially available), progesterone (available as Commercially available), salmon calcitonin (available as Commercially available), calcitriol (available as Commercially available), levothyroxine (available as Commercially available), testosterone (available as and commercially available); menopausal medications such as estradiol / norethindrone acetate (available as Commercially available), drospirenone / estradiol (available as Commercially available), estradiol / levonorgestrel (available as Climara Commercially available), estradiol / norethindrone acetate (available as Commercially available), estradiol (available as and commercially available), esterified estrogens, and methyltestosterone (available as Commercially available), estrogen (available as Commercially available), estrone sulfate piperazine (available as Commercially available), conjugated estrogens (available as commercially available) and medroxyprogesterone acetate (available as commercially available); menstrual medications, including leuprolide acetate (available as Lupron Depot), tranexamic acid (available as Commercially available) and norethindrone acetate (available as and muscle relaxants, including cyclobenzaprine hydrochloride (available as Commercially available), tizanidine (available as Commercially available) and scopolamine sulfate (available as Commercially available).

[0157] Active substances useful herein may also include osteoporosis drugs, including ibandronate sodium (available as Commercially available), risedronate (available as Commercially available), raloxifene hydrochloride (available as commercially available) and alendronate sodium (available as commercially available); ovulation promoters, including clostilbene citrate (available as Paget's disease treatment agents, such as etidronate disodium (available as commercially available); pancreatic enzyme deficiency drugs, such as pancreatic lipase (available as or drugs used to treat Parkinson's disease, such as pramipexole hydrochloride (available as Commercially available), ropinirole hydrochloride (available as commercially available), carbidopa / levodopa (available as Sinemet Commercially available), carbidopa / levodopa / entacapone (available as Commercially available), selegiline hydrochloride (available as Commercially available), rasagiline (available as Commercially available), entacapone (available as Commercially available) and selegiline hydrochloride (available as multiple sclerosis drugs, such as dalfampridine (available as Commercially available) and interferon beta-I b (available as commercially available); prostate drugs, including flutamide (available as Commercially available), nilutamide (available as Commercially available), dutasteride (available as Commercially available), tamsulosin hydrochloride (available as Commercially available), terazosin hydrochloride (available as Commercially available) and alfuzosin hydrochloride (available as Commercially available).

[0158] Active substances may also include psychotropic drugs, including alprazolam (available as available from available from Fluoxetine hydrochloride (available as Available from Asenapine (available as Commercially available), iloperidone (available as Commercially available), paroxetine hydrochloride (available as Commercially available), aripiprazole (available as Commercially available), guanfacine (available as Commercially available), amphetamine, and methamphetamine (available as and Commercially available), clomipramine hydrochloride (available as Commercially available), buspirone hydrochloride (available as Commercially available), Citalopram hydrobromide (available as Commercially available), duloxetine hydrochloride (available as commercially available), methylphenidate (available as Ritalin, Commercially available), divalproex sodium (valproic acid) (available as Commercially available), dextroamphetamine sulfate (available as Commercially available), venlafaxine hydrochloride (available as Commercially available), selegiline (available as Commercially available), carbamazepine (available as Commercially available), lithium carbonate (available as Commercially available), fluvoxamine maleate / dexmethylphenidate hydrochloride (available as Commercially available), Ziprasidone hydrochloride (available as Commercially available), dihydroergotamine mesylate (available as Commercially available), escitalopram oxalate (available as Commercially available), chlordiazepoxide (available as Commercially available), molinone hydrochloride (available as Commercially available), phenelzine sulfate (available as Commercially available), thiothixene (available as Commercially available), desipramine hydrochloride (available as commercially available), benzodiazepines (such as those obtained), nortriptyline hydrochloride (available as Commercially available), cyclopropylamine sulfate (available as Commercially available), prochlorperazine, mirtazapine (available as Commercially available), risperidone (available as Commercially available), quetiapine fumarate (available as Commercially available), doxepin hydrochloride (available as Commercially available), atomoxetine hydrochloride (available as Commercially available), trimipramine maleate (available as Commercially available), olanzapine / fluoxetine hydrochloride (available as Commercially available), imipramine hydrochloride (available as Commercially available), protriptyline hydrochloride (available as Commercially available), bupropion hydrochloride (available as Wellbutrin Wellbutrin Commercially available) and olanzapine (available as Commercially available).

[0159] Active agents useful herein may also include uric acid reducing therapeutic agents, including allopurinol (which may be used as commercially available); seizure medications, including gabapentin (available as Commercially available), ethotoin (available as Commercially available), vigabatrin (available as Commercially available) and topiramate (available as commercially available); herpes zoster treatments, such as herpes zoster virus live vaccine (available as commercially available); skin care drugs, including calcipotriol (available as Commercially available), Ustekinumab (available as Commercially available), telavancin (available as Commercially available), isotretinoin (available as Commercially available), hydrocortisone / iodoquinol (available as Commercially available), sulfacetamide sodium / sulfur (available as Commercially available), azelaic acid (available as Commercially available), benzoyl peroxide (available as Commercially available), Adapalene (available as Commercially available), fluorouracil (available as Commercially available), pimecrolimus (available as Commercially available), topical erythromycin (available as Commercially available), hydrocortisone (available as Commercially available), metronidazole (available as Commercially available), doxycycline (available as Commercially available), retinoic acid (available as and Commercially available), para-methoxyphenol / retinoic acid (available as Commercially available), Acitretin (available as Commercially available), calcipotriol hydrate / betamethasone dipropionate (available as Commercially available), tazarotene (available as Commercially available), fluocinolone acetate (available as Commercially available), desonide (available as Commercially available), miconazole nitrate / zinc oxide (available as Commercially available), ketoconazole (available as Commercially available) and efalizumab (available as Commercially available).

[0160] Other active substances that can be used herein can include sleep disorder medications, including zaleplon (which can be used as Available from commercially available), zolpidem tartrate (available as Ambien Commercially available), lorazepam (available as Commercially available), flurazepam hydrochloride (available as Commercially available), triazolam (available as Commercially available), clonazepam (available as Commercially available), barbiturates (available as Commercially available), modafinil (available as Commercially available), temazepam (available as Commercially available), Remetiion (available as Commercially available), dipotassium chloramine (available as Commercially available), diazepam (available as commercially available), quazepam (available as Commercially available) and estazolam (available as commercially available); smoking cessation medications, such as varenicline (available as commercially available), nicotine (such as ) and bupropion hydrochloride (available as commercially available); and steroids, including alclomethasone dipropionate (available as Commercially available), betamethasone dipropionate (available as Commercially available), mometasone furoate (available as Commercially available), fluticasone (available as Flovent Flovent Commercially available), fluocinolone acetate (available as Commercially available), mometasone furoate monohydrate (available as Commercially available), desoxymethasone (available as Commercially available), clotrimazole / betamil dipropionate (available as Commercially available), prednisolone acetate (available as Pred Budesonide Rhinocort Commercially available), prednisolone sodium phosphate (available as Commercially available), desoneide (available as Commercially available) and halobetasol propionate (available as Commercially available).

[0161] Other active substances can be used in the treatment of thyroid diseases, such as hormones TC and TD (can be used as Armour commercially available); potassium deficiency treatments, including potassium chloride (available as commercially available); triglyceride regulators, including ω-3 acid ethyl esters (available as commercially available); urinary drugs, such as phenazopyridine hydrochloride (available as commercially available) and methenamine, methylene blue / phenyl salicylate / benzoic acid / atropine sulfate / scopolamine (available as commercially available); vitamins for prenatal care (available as Advanced Prenate weight management drugs, including orlistat (available as Commercially available) and sibutramine hydrochloride (available as Commercially available).

[0162] Popular H2 antagonists contemplated for use herein include cimetidine, ranitidine hydrochloride, famotidine, nizatidine, ebrotidine, mifentidine, roxatidine, pisatidine, and aceroxatidine.

[0163] Active antacid ingredients include, but are not limited to, the following: aluminum hydroxide, dihydroxyaluminum aminoacetate, aminoacetic acid, aluminum phosphate, sodium dihydroxyaluminum carbonate, bicarbonate, bismuth aluminate, bismuth carbonate, bismuth subcarbonate, bismuth subgallate, bismuth subnitrate, bismuth subsalicylate, calcium carbonate, calcium phosphate, citrate ion (acid or salt), aminoacetic acid, hydrated magnesium aluminum sulfate, magnesium aluminum hydroxide, magnesium aluminum silicate, magnesium carbonate, magnesium glycinate, magnesium hydroxide, magnesium oxide, magnesium trisilicate, milk solids, aluminum mono-ordibasic calcium phosphate, tricalcium phosphate, potassium bicarbonate, sodium tartrate, sodium bicarbonate, magnesium aluminosilicate, tartaric acid and salts.

[0164] Pharmaceutically active agents of secondary use in the present invention may include allergens or antigens, such as, but not limited to, plant pollens from grasses, trees, or ragweed; and animal dander, which is the tiny scales that fall from the skin and hair of cats and other furry animals; insects, such as house dust mites, bees, and wasps; and drugs, such as penicillin.

[0165] Examples of specific active substances include, but are not limited to, 16-alpha fluoroestradiol, 16-alpha-gemtocine, 16-epiestriol, 17alpha dihydroestradiol, 17alpha estradiol, 17beta estradiol, 17-hydroxyprogesterone, 1alpha-hydroxyvitamin D2, 1-dodecylpyrrolidone, 20-epi-1,25-dihydroxyvitamin D3, 22-oxocalcitriol, 2CVV, 2′-nor-cGMP, 3-isobutyl GABA, 5-ethynyluracil, 6-FUDCA, 7-methoxytacrine, avermectin, abanoquine, abecar, abiraterone, alukast, alukast sodium, acadesin, acamprosate, acarbose, acebutolol, acecaine hydrochloride, aceclidine, aceclofenac, acetyldapsone , acetaminophen, acetazolamide, acetophenone sulfonyl cyclohexyl urea, acetohydroxyamine, acetomepregenol, acetophenazine maleate, sodium sulfadiazine, acetylcholine chloride, acetylcysteine, acetyl-L-carnitine, acetylmethadol, acifuran, acipimox, acitretin, acitretin, acivicin, aclarubicin, akodazol hydrochloride, aconiazid, acrivastine, aclonine, axomide, atodigin, acyclovir, acylfuwen, adapalene, adapalene, adaserin, adaserin hydrochloride, adenosine, adenosine, adefovir, ademidrin, adenosine methionine, adenosine, adinazolamide, adifenin hydrochloride, human lipid-lowering hormone (ad iposin), adolesin, adrafenib, adrenaline, airbutamine, alacepril, aletomycin, alanine, alapropylate, alatide, albendazole, white-lipped bamboo leaf green, salbutamol, albutin, Alclofenae, aclomethasone dipropionate, aluminum closa, aldecalmycin, aldesleukin, aluminum allantoin, alendronate sodium, alendronic acid, alentimod, alentimod hydrobromide, alentimod hydrochloride, alcuronium chloride, alexidin, alpha-calciferol, alfentanil hydrochloride, alfuzosin, algesterone acetate, arabinosidase, aleflurane, alinelastine, aripamil, diallylbarbital, allopurinol, ALL-TK antagonist, alogliptin, Allomidone, alosetron, alosetron hydrochloride, alovudine, alpertin, alpha amylase, alphaidosone, alpitant, alprazolam, alprenolol hydrochloride, aprinocin hydrochloride, alprostadil, astatin sodium, atanserin tartrate, alteplase, althiazide, hexamethylenetetramine, atomycin B, alverine citrate, aveshuto, amadinone acetate, amantadine hydrochloride, amoxicillin, ambromycin, ambutin, ambutin, ambutine, ambuside, ancifar, amcinonide, mecillinam, pivmecillinam, ametadrine hydrochloride, alometasone, amitoli, anergo, ametinol acetate, ametinol methylsulfoxide, bupropion, amfenac sodium, amifentazole, amicycline, amideforin, amidox, amlofloxacin, amifostine,Amikacin, amiloride hydrochloride, aminoacridine hydrochloride, potassium aminobenzoate, sodium aminobenzoate, aminocaproic acid, aminoglutethimide, sodium aminohippurate, aminolevulinic acid, aminophylline, amyrex, sodium aminosalicylate, aminosalicylic acid, amiodarone, ampridose hydrochloride, aminoquine hydrochloride, amisulpride, amitraz, amitriptyline hydrochloride, amiloxanol, amlodipine, amobarbital sodium, amodiaquine, amodiaquine hydrochloride, amorolfine, amoxapine, amoxicillin, chloral, amphetamine sulfate, amphetamine, amphetamine B, ampicillin, ampiroxicam, dimethoate sulfate, aminoquinate, amrinone, amrubicin, amsacrine, amylase, amylase anastrozole, anastrozole, anastrozole sodium, ancrodase, andrographolide, androstenedione, angiotensin amide, anidoxime, anilidine, anilopam hydrochloride, aniracetam, aniroic acid, methylbromide, anistreplase, anistreplase, anorthrin, antagonist D, antagonist G, anrelix, antazoline phosphate, anti-antramycin, anthralin, anthramycin, anti-androgen, anti-estrogen, anti-neoplaston, antipyrine, antisense oligonucleotide, apadolin, apapan, apacillin sodium, an Patphylline, Azapropazone, Aphidicolin Glycine, Apixifylline, Apomorphine Hydrochloride, Apoclonidine, Apoclonidine Hydrochloride, Amp, Aprindine, Aprindine Hydrochloride, Aprithione Sodium, Aprotinin, Aprazapine Maleate, Atiganel, Purine Acid, Purine Acid, Aranidipine, Alanotein, Abaprost, Arbekicin, Arbidol, Abutamine Hydrochloride, Alclofenine, Adeparin Sodium, Argatroban, Arginine, Arginine Tannate, Arizone, Aripiprazole, Armofenil, Arotinolol, Arpinocid, Atifuline, Atifuline Fumarate, Asimadolin, Aspalathin e, asparaginase, aspartic acid, aspartate, asperfuran, aspirin, apoxicillin, Asprelin, astemizole, astemizole sulfate, asulacrine, atamestane, atazanavir, atenolol, ativeridine, atipamezole, atipromazine maleate, atolite, atomoxetine, atorvastatin, atorvastatin calcium, atosiban, atovaquone, atpeninB, atracurium besylate, amustine, atroinositol, atropine, atropine sulfate, auranofin, aurobacitin A, aurothioglucose, benomyl, avoparcin, avridine, nizatidine, axinastatin 1. axinastatin 2. axinastatin 3. azabenidine, azacitidinie, azachloramine hydrochloride, azaconazole, azadirachtine, azalanstat dihydrochloride, azaconazole, azanatol maleate, azanidazole, azaperone, azaripiprone, diazoacetylserine, azasetron,Azatadine maleate, azathioprine, azathioprine sodium, azatoxin, diazotyrosine, azelaic acid, azelastine, azelnidipine, azaindole, azatep, azithromycin, azlocillin, azolimine, azosemide, azomycin, aztreonam, azumolyn sodium, bacampicillin hydrochloride, baccatin III, bacitracin, baclofen, bacopa saponin A, bacopa saponin B, bactobolamine, balanol, balazipone, bal himycin, balofloxacin, balsalazide, bambuterol, bamesen sulfate, bamiphylline hydrochloride, pannidazole, baohuoside 1, bamiastine, barnidipine, bismuth subsalicylate, brazifungin, batapride hydrochloride, babubester, batirapine maleate, batimastat, beauvericin, thioxanthone hydrochloride, becaplermin, beconazole, beclomethasone dipropionate, befloxatone, beinserazide, befodinil, belladonna, beloamide, bemistron, Bemidrol, bemoradan, benaclizine hydrochloride, benazepril, benazepril hydrochloride, benazeprilat, bendalol sulfonate, bendamustine hydrochloride, bendacid, bendrofluazide, benfluanid, benidipine, benotestosterone, benoxaprofen, benoxaprofen, oxybuprocaine hydrochloride, benperidol, benzazepam, benztyramide, benustat, benzbromarone, benzethonium chloride, benzylthamide hydrochloride, benzylpyrrolium bromide, benzylpyrine hydrochloride, benzisoxazole, benzocaine, benzoridin, benzotamine hydrochloride , benzotepa, benzoidazoxan, benzonatate, benzoyl peroxide, calcium benzoate, benzoylstaurosporine, benzquinamide, benzthiazide, benztropine, benztropine mesylate, benzydamine hydrochloride, benzathiazine benzoate, bepridil, bepridil hydrochloride, belacontan, beraprost, bereforin, berafenone, betoxamil, deoxyerythromycin, besipiridine, betaalethine, betaclamycin B, betamethasone, betamipron, betaxolol, betaxolol hydrochloride, choline chloride, betanidine sulfate, betulinic acid, bevacizumab, bevantolol, bevantolol hydrochloride, bezafibrate, biramic acid hydrochloride, biapenem, bicalutamide, bicifadine hydrochloride, diclofenac hydrochloride, bidisamide, bifenamyl, bifonazole, bicarin, bimatoprost, bimithil, bindali, binimycin, bispirone, bioxalomycin α2, biperidol hydrochloride, biperiden, phensalamide hydrochloride, biperone, bisantrene, bisaremide, bisaziridinylspermine, bisbenzimidazole A, bisbenzimidazole B, binefad, bisoprolol lactate, bisoprolol, bisoprolol fumarate, magnesium pyrithione, bistramide D, bistramide K, bistratene A, sodium thiobisdichlorophenol, nortestosterone undecylenate, ethylestradiol, bomantonil, bopindolol, bosentan, botulinum toxin, boxidin,Brefeldin, breflate, buquinal sodium, brometazidine, brompheniramine tosylate, bufentanyl hydrochloride, brimonidine, fibrase, bromocricin, bromocriptine, bromoquinoxaline, bromoquinoxaline maleate, bromazepam, bromochloridone, bromelain, bromfenac, brominidione, bromocriptine, bromophenolamine hydrochloride, bromosanide, brompyridol, brompyridol decanoate, brompheniramine maleate, bromopimol, bropiridol, brotizolam, bucamyl maleate, bucinolol, buclizine hydrochloride, buchromone, budesonide, budesonide, budoti, buformin, bumetanide, bunalast, bunazosin , bunolol hydrochloride, butopicolide, bupivacaine hydrochloride, buprenorphine, buprenorphine hydrochloride, bupropion, bupropion hydrobromide, bupropion hydrochloride, bupropion ester, buserelin acetate, buspirone hydrochloride, busulfan, butabarbital, butacetin, butalamol hydrochloride, butalbital, butamben, butamidate citrate, butapiperazine, butaprost, butidronate tetrasodium, butenafine, butirizine, buthioninesulfoximine, butikacin, butyric acid, butyric acid sulfate, butyric acid, butyric acid propionate, butyric acid nitrate ... Propidium, Butorphanol, Butoxamine Hydrochloride, Butyrin Hydrochloride, Cabergoline, Actinomycin C, Cadex, Iodine, Caffeine, Red Sclerosis Plant Extract A, Calcifediol, Calcipotriol, Calcipotriol, Calcitonin, Calcitriol, Calcium Undecylenate, Calcium Phosphate Protein C, Captestosterone, Canbendazole, Camogre, Camptothecin Derivatives, Canagliflozin, Canarypox IL-2, Candesartan, Candesartan Cilexetil, Candidiacetin, Canxatril, Canxatrilat, Caniglibose, Canrenoate Potassium, Canrenone, Capecitabine, Sodium Crotonate, Crotonate, Capromycin Sulfate, Capromonab, Capsaicin, Captopril, Carbomer, carbocysteine, carbamazepine, urea peroxide, chlorpheniramine dodecyl sulfate, carbaspirin calcium, carbazelan, carbamazepine C, carbenicillin potassium, sodium carbenoxolone, carbetol, carbetocin, carbidopa, carbidopa, levodopa, carbinoxamine maleate, carbifen hydrochloride, carbochloral, carbolic acid, fuchsin, carboplatin, carprofen, carbophor, carboxyamide-amino-triazole, carboxyaminotriazole, carboxymethyl β-1,3-glucan, carbuterol hydrochloride, CaRestM3, carfentanil citrate, carisoprodol, carammonia acid, carmustine, CARN 700, carnidazole, caroxadone, caperitide, propionylperphenazine maleate, carprofen, casatran succinate, cartazoline, carteolol, carteolol hydrochloride, carrubicin hydrochloride, carvedilol, carvotreline, carvotreline hydrochloride, carzeresin, caspofungin (ICOS), castanospermine, caurumonam, cibacitam, antimicrobial peptide B, sidifingol, cefaclor, cefadroxil, cefamandole, cefoperazone, ceftriaxone, cefazolin,Cefcaprenol, cefotaxime tosylate, cefdinirb, cefditoren pivoxil, cefepime, cefetamet, cefoteico, cefixime, cefuroxime, cefmenam, cefmetazole, cefminox, cefodizime, cefonicid sodium, cefoperazone, cefoperazone sodium, cefoperazone, cefotetan, cefotetan, cefoxitin, cefazolin, cefimidazole, cefpiramide, cefpirome, cefpodoxime proxetil, cefprozil, ceftriaxone, cefsulodin, ceftazidime, cefditoren, ceftibuten, cefuroxime sodium, ceftriaxone, cefuroxime, triptolide, celecoxib, celikalim, celiprolol, cepacidiine A, Ceftriaxone Sodium, Cephalexin, Cefuroxime, Ceftriaxone Sodium, Cefpirin Sodium, Cefuroxime, Cefuroxime, Ceftriaxone Sodium, Cefuroxime, Cefuroxime, Ceftriaxone Sodium, Cefuroxime, Cefuroxime, Ceftriaxone Sodium, Cefuroxime, Cefuroxime, Ceftriaxone Hydrochloride, Cetirizine, Cetrimide, Cetuximab Hydrochloride, Cetirizine Hydrochloride, Cetuximab, Cetuximab, Cetuximab, Cetuximab Hydrochloride, Chenodeoxycholic Acid, Chlorophenol Diphenylamine Hydrochloride, Chloral Betaine, Chlorambucil, Chloramphenicol, Chloropropamide, Chloroquine, Chloroquinoxaline sulfonamide, chlorothiazide, chlorethoxyquine, dichlorohydroxyquine, chloroxylenol, chlorpheniramine maleate, chlorpheniramine aminoester, chlorpheniramine maleate, chlorpromazine, chlorpromazine hydrochloride, chlorsulfuronamide, chlorprothixene, chlortetracycline hydrochloride, chlorthalidone, chlorzoxazone, cholestyramine resin, carbomer hydrochloride, ciprofloxacin, cicaprost, cycloforin hydrochloride, fenazolin, ciclesonide, cilathione, ciclopirox, ciprofen, ciprofenolol, cidofovir, cidoxepin hydrochloride, ciprofloxacin, ciglitazone, ciradopa hydrochloride, cilansetron, cilastatin, cilastatin sodium, cilazapril, cilnidipine, cilopamine mesylate, ciloradine, cilofungin, cilostazol, cimaterol, cimetidine, cimetropium bromide, calcium mimetic drugs , Cinalast, cinaserin hydrochloride, cinapride maleate, cyfluamine, engestrol, cinipride, cinamidrine, cinorizine, cinazepam, cinoxacin, cinapride, cinbromide, cinpentazone, cintroamide, sirolane, cipantheline, ciprofadol succinate, ciprosonide, ciprofibrate, ciprofloxacin, ciprostenol, siramadol, siromycin, cisplatin, cisapride, cis-atracurium besylate, cisconazole, cisporphyrin, citalopram, citalopram hydrobromide, citamide, citicoline, citreamicin α, cladribine, chloramine hydroxyquinol hydrochloride, clarithromycin, xanthineamide, clavulanate potassium, clarathazone, chlorbenzolam, clebopride, clemastine, clentiazem maleate, clarithromycin bromide, clinafloxacin,Clindamycin, clindamycin hydrochloride, cloiodoxyquin, cloiodixanil, clerofen, clobazam, clobetasol propionate, clobetasone butyrate, clocortolone acetate, chlordanol, chlordone hydrochloride, clodronic acid, clofazimine, clofibrate, chlorpheniramine phosphate, chlorpromazine acetate, clomazine phosphate, clomegestrol acetate, clomedroxyprogesterone acetate, clomethiazole, clomiphene analogs, clomiphene citrate, clomiphene citrate, clomipramine hydrochloride, clonazepam, clonidine, clonidine hydrochloride, clonoglycerol, clonisele, clonixin, clopamide, clopenthixol, clopiperidone hydrochloride, clopidogrel, clopidogrel hydrogen sulfate, clopimozil, clopiperidone mesylate raw, clopirac, cloprednisolone, cloprostenol sodium, dipotassium chlordiazepoxide, cloxolone, cloperone hydrochloride, cloprenaline hydrochloride, closulon, chlortermide hydrochloride, closanthemid, acetylglycine cloxylamine, clothiapine, maleic chloramine thioxanthene, clothiocarbone propionate, clotrimazole, benzathine cloxacillin, cloxacillin sodium, clohydroxyquine, clozapine, amoxicillin potassium clavulanate mixture, cocaine, coccidioidomycin, codeine, codeine phosphate, codoxine, colchicine, colestipol hydrochloride, colestipol, colestipol, colforsine, colforsili palmitate, colistin sodium mesylate, colistin sulfate, collismycin A, collismycinB, colterol mesylate, combretastatin A4, complestatin, conagenin, Conorphone hydrochloride, colterol, contortrostatin, cormethasone acetate, cortisol Ovine Triflutate, adrenocorticotropic hormone, cortisone, cortisol acetate, cortodoxone, cosalane, costatolide, synthetic corticotropin, cotinine, coumadin, coumarin, crambescidin 816, crivastatin, clinato, clomiprole sodium, sodium cromoglycate, crotamiton, cryptophycin 8, cucumariosid, copper mycin, curacin A, curdlan sulfate, curiosin, cyclopentyl penicillin, cyclozosin, cyclo-HPMPC, amine hydrocarbazole, cylilamin maleate, cyclizine, cyclobendazole, cyclobenzaprine, cyclobutanecarboxylic acid A, cyclobutanecarboxylic acid G, cyclocapron, cyclochloranol pamoate, cycloheximide, cyclopentanthraquinones, cyclopentathiazide, cyclopentolate hydrochloride, ciprofen hydrochloride, cyclophosphamide, cycloplatam, cyclopropane, cycloserine, cyclosin, cyclosporine, cyclothialidine, cyclothiazide, cyclothiazomycin, cycloheptamide, cypemycin, Cyponamine hydrochloride, ciproazepam, cyproheptadine hydrochloride, cyproterone hydrochloride, cyproterone, cypromide, cysteamine, cysteine ​​hydrochloride, cystine, cytarabine, cytarabine hydrochloride, cytarabine ocfosfate, cytochalasin B,hexylestradiol phosphate, dacarbazine, dacximab, datimicin, dactinomycin, soy daidrin, dalfopristin, dalteparin sodium, daltroban, dalvastatin, danaparin, danazol, dantrolene, daphnodorin A, dapoxetine, dapoxetine hydrochloride, dapsone, daptomycin, daptoprotin alfa, dalitrizone sodium, darifenacin, darlucin A, darodipine, dasidomine, daunorubicin hydrochloride, dazanol maleate, azodil hydrochloride, damegrelide, dazopride fumarate, dazopride hydrochloride, isoquinol sulfate, decitabine, deferiprone, deflazacort, deoxycholic acid, dehydrodidemnin B. Dehydroepiandrosterone, delapril, delapril hydrochloride, delavirdine mesylate, dilequat, defapirazine, delmadinone acetate, delmopinol, delphinidin, demeclofenac, demeclocycline, demeclocycline, demozepam, denocycline, deoxypyridinoline, divalproex sodium, deproton, deprost, depsidomycin, deramciclane, dermatan sulfate, deciclovir, desinonide, desflurane, desipramine hydrochloride, desirudin, deacetyl lanolin, delostatin, delorelin, desmopressin, desmopressin sulfate, desogestrel, desmogestrel ned, desoximetasone, desoxoamiodarone, deoxycorticosterone acetate, detajmium tartrate, detenol hydrochloride, detetrol acetate, devacipil, dexamethasone, dexamidazole, dexchlorpheniramine maleate, dexchlorpheniramine maleate, cyproheptadine hydrochloride, dexbenzylamide, dexfenfluramine hydrochloride, dexifosfamide, benzimidazole, dexketoprofen, dexloglutamine, medetomidine, dexomaplatin, dexoxadrol hydrochloride, dexpantinol, dexpemetrexate, dexpropranolol hydrochloride, dexrazoxane, dexsotalol, dextrin 2 -sulfuric acid, dextroamphetamine, dextromethorphan, dextrorphan hydrochloride, dextrothyroxine sodium, dexverapamil, dezaguanine, dezinamide, dezocine, diacetolol hydrochloride, diaminocaine cyclamate, chloramphenicol, diatrizoate, diatrizoate, diaminoveratridine, diazepam, diazadione, diazoxide, dibenzothiophene hydrochloride, dibucaine, Dichliorvos, chloralphenazone, dichlorosulfamide, dicirenone, diclofenac, diclofenac sodium, dicloxacillin, dicranin, dicoumarin, dicyclomine hydrochloride, didanosine, diclofenac B, did ox, diethylstilbestrol, dienogest, diethylcarbamazine citrate, diethylhomospermine, diethylnorspermine, amfepramone hydrochloride, diethylstilbestrol, cyperamide hydrochloride, difenoxin, diflorasone diacetate, difloxacin hydrochloride, Difluanine hydrochloride, diflucortolone, diflumizone sodium, diflunisal, difluprednate, diflustatone, digitalis, digitalis glycosides, digoxin, dihexiverine hydrochloride, direceptor agonists, dihydro-5-azacytidine, dihydrotartaric acid, dihydroergotamine mesylate,Dihydroestosterone, dihydrostreptomycin sulfate, dihydrotachysterol, phenytoin sodium, dilevolol hydrochloride, diltiazem hydrochloride, dimethifedrine, dimetholine hydrochloride, dimenhydrinate, dimethadione, dimethylindine maleate, dimethinone, dimethyl sulfoxide, dimethylhomospermine, dimethylprostaglandin aluminum, dileracetam, Dimoxamine hydrochloride, dinoprost, dinoprostone, dioxadrol hydrochloride, dioxamycin, diphenhydramine, diphenhydramine citrate, diphenidol, diphenoxylate hydrochloride, diphenylspiromustine, dipivefrin hydrochloride, dipivefrin, diplienc yprone, dipropylnorspermine, dipyridamole, dipyrithione, analgin, erythromycin, discodermolide, disobudaline, disophenone, disopyramide, dioxalide, disulfiram, ditikiren, divalproex sodium, dizocilpine maleate, dobutamine, docarbamine, docebenone, docetaxel, doconazole, docosanol, dofetilide, dolasetron, donepezil, donipenem, dorzolamide, doxazosin, doxazosin mesylate, doxycydine, drospirenone, duloxetine, dutasteride, ebastine, ibiratide, ebretidine, ebselen, ecapeptide, ecapate, ecadil, ecdisteron, echi cetin, scaly viper blood inhibitory peptide, iodine icosate, elclonamine maleate, etzolast, icomustine, econazole, ecteinascidin 722, eculizumab, edaravone, edatrexa, edifosine, edifolone acetate, ebamab, edouridine, edrecolomab, edrophonium, edroxyprogesteone acetate, efavirenz, efagatran, eflornithine, efodipine, egualcen, ylan group, eleatonin, elemene, eletriptan, eligodipine, elirodine, elsamicin, eltenae, ilucaine, emailcalim, emedastine, emetine hydrochloride, emiglitate, Emilium tosylate, etofentipine, efavirenz Interleukin, Emtricitabine, Enalapril Hydrochloride, Enailciren, Enalapril, Enalapril Maleate, Enazatrine, Enciprolate, Endrazide Mesylate, Methotrexate, Enflurane, Englitazone, Enconazole, Enprostil, Enmomob, Enloplatin, Enolast, Enorcon Sodium, Enoxacin, Enoxacin, Enoxaparin Sodium, Enoxaparin Sodium, Enoximone, Enperoline Phosphate, Enprophylline, Enprobamate, Entacapone, Enterostatin, Enviraden, Enviroxime, Ephedrine, Epicillin, Epimestranol, Epinephryl Borate, Epipiperidine, Epipirazol, Epirubicin, Epitetracycline Hydrochloride, Epithiazide, Erythropoietin Alpha, Erythropoietin Beta, Epoprostenol, Epoprostenol Sodium,epoxymexrenone, aprilate, eprosartan, estigmine, dehydroequilin, equilin, erbuprozole, erdosteine, ergoline mesylate, ergonovine maleate, ergotamine tartrate, erlotinib, esentilate, ersofermin, erythritol, erythritol tetranitrate, erythromycin, erythropoietin, escitalopram, esmolol hydrochloride, esomeprazole, esorubicin hydrochloride, ethathionylproquine hydrochloride, sulphenazine, estradiol, estramustine, estradiol hydrobromide, estriol, estrogens, estrone, estrone piperazine thioester, ethsulfapron, eszopiclone, ethadone hydrochloride, etanercept, etanidazole, etantrol, etalotin, etazolidin hydrochloride , Eterbital, Ethylthiazine, Sodium ethanoate, Ethanoic acid, Ethambutol hydrochloride, Vanillyl diethylamine, Ethanolamine oleic acid, Ethehlorvynol, Ethembutol hydrochloride, Ethinyl estradiol, Ethiodized oil, Ethionamide, Etonan nitrate, Profenamide hydrochloride, Ethosuximide, Ethosuximide, Ethyltoin, Ethoxydiaminoazobenzene hydrochloride, Ethylbenztropine, Ethyl chloride, Ethyl dibunate, Ethylestrenol, Ethyndiol, Dehydrochloronorphisterone, Ethinyl estradiol, Ethinyl estradiol diacetate, Ebendazole, Etidocaine, Etidronate disodium, Etidronic acid, Etifenin, Etintidine hydrochloride, Etizolam, Etodolac, Etofenamate, Etoformin hydrochloride, Etomidate, Etonogestrel, Etoperidone hydrochloride ketone, etoposide, chlorpheniramine, etoricoxib, etofenoxadine hydrochloride, etofenoxadine, etrobamine, etravirine, etretinate, ethiamine acetate, eucatropine hydrochloride, eugenol, euprosin hydrochloride, eveminomicin, exametoxime, ixarelin, hexadol hydrochloride, exemestane, fadrozole, faeriefungin, famciclovir, famotidine, aminopyridine, pantofarone, pantofenone hydrochloride, faropenem, fasidotril, fasudil, fazarabine, fedotozin, felbamate, felbamate, felinac, felodipine, felypressin, fenalamide, fenamox, fenbendazole, fenbufen, fencibutol, fenclorac ... estradiol, fenfluramine hydrochloride, fenfluramine hydrochloride, fengabine, phenamide, phenirex, clofenoxazole hydrochloride, phenmethon, fenobane, fenoxantamine sulfate, fenofibrate, fenoldopam, fenoprofen, fenoterol, phenoxadione, fenprolast hydrochloride, fenproline, fenquinazole, fenretinide, fenspiride, fentanyl, fentanyl citrate, fentiazine, fenticol, fenticonazole, fenidol hydrochloride, fepristinol, ferpifosate sodium, ferristene, ferrixan, ferrous sulfate, dry, superparamagnetic iron oxide, femoxil, fetosil hydrochloride, fexofenadine, fezolamine fumarate, fecitabine, fenaridine, fibrinogen 1 125. Filgrastim, Filapipine, Flavopiridol Maleate, Flavopiridol, Flavopiridol Hydrochloride, Flavazadone, Flecainide,flubuterol, fleroxacin, fluoxetine, flusinoxan, flusulol sulfate, fluethazepam, fluzelastine, flobufen, flufenam, fludipine, flusquinac, flucloxacillin, floxuridine, fluasterone, fluzacort, flubanate hydrochloride, flubendazole, flucindole, flucindole, fluconazole, flucytosine, fluorodeuterated alanine, fludarabine phosphate, clofludazole, fluorodeoxyglucose F18, fludorex, fludrocortisone acetate, flufenamic acid, flufensal, flumazenil, flumequine, flumeridone, flumethasone, flumetasone, flumetazone, flumethazapine, fluamine, fluimidazole, flumonide, flunisolide, flunitrazepam, flunixin, fluocalcitriol, fluocinolone acetonide, flutolane acetate Relax, flucoside butyl, fluocortolone, fluorescein, fluorodaunorunicin hydrochloride, fluorodopa F18, fluorometholone, uracil, flutricarcin hydrochloride, fluoxetine, fluoxetine hydrochloride, fluoxymesterone, fluperolamine, fluperone acetate, fluphenazine decanoate, fluprednisolone, fluprostenol sodium, fluquinazone, fludolin hydrochloride, fluhydroxycortisone, flurazepam hydrochloride, flurbiprofen, fluretofen, flucitabine, flufamine, fluprogesterone acetate, trifluralin, fluorovinyl ether, fluspirone, fluspirine, fluticasone, fluticasone propionate, flutracin, fluvastatin, fluvastatin sodium, fluazifop, folic acid, follicle regulating protein, follicle-stimulating hormone, follicle-stimulating hormone alpha, follicle-stimulating hormone beta, methazole, dimethazine mesylate, fora Sartan, forfenirmex, formestan, formocort, formoterol, fosfoline, fosazepam, foscarnet sodium, fosfomycin, fosfoacetate sodium, fosinopril, fosinopril sodium, fosinoprilat, fosphenytoin, fosquinone, forsostidil, fostricin, fotemustine, fuchsin, furoxicillin, fungicidal, furaprofen, furazolidinium, furoglar sodium, furobufen, furodazole, furosemide, fusidate sodium, fusidic acid, gabapentin, gadobenate dimeglumine, gadobenic acid, gadobutrol, gadodiamide, gadotexaphyrin, magnavitin solution Dimegiumine, gadoteric acid, gadoteridol, gadoversetamide, galantamine, gadodensetron, gadodensetron hydrochloride, goralium iodide, nitric acid Gallium, gallopamil, galocitabine, genfexin, gamoenic acid, ganciclovir, ganirelix, tetramethyldecanediol, gemcitabine, gemeprost, gemfibrozil, gentamicin sulfate, gentian violet, gepirone, pregnathia, gestodene, pregnenolone caproate, pregnenolone, givotrien hydrochloride, girisopam, insulin glargine, glaumod, glautiram, glaucocalyxinA, gliserine, glibenclamide, gliprexa, glitanylate sodium, gliflunomide, glimepiride, glipizide, glomonam, glucagon, glutapyrone, glutethimide, glyburide, glycopine, glycopril, glycopyrrolate, glihexamide, glipizide sodium, glisinamide, glipamulide, Gold Au 198,Gonadoctrinins, gonadorelin, gonadotropin, goserelin, gramicidin, granisetron, grepafloxacin, griseofulvin, guaifenperd, guaiacyl, guanabenzyl acetate, guanadrenolide sulfate, guanacetidine, guanethidine monosulfate, guanfacine hydrochloride, guanisoquinol sulfate, guanocetine hydrochloride, guanoxabenzyl, guanoxetine sulfate, guanoxifene sulfate, guarlimus trihydrochloride, halazepam, halcinonide, halichondrin B, halobetasol propionate, haloperidol, haloperidol hydrochloride, halofenol hydrochloride, halofenol hydrobromide, bromochloropiperazine hydrobromide, halomon / haloperidol, haloperidol, halopredin, halopredin, halothane, halquinol, halomycin, hatomamicin, hatomarubigin A, hatomarubigin B, hatomarubigin C, hatomarubigin D. Heparin sodium, hepsulfam, regulatory protein, hetacillin, heteronium bromide, hexachlorophene: hydrogen peroxide, hexafluoramide bromide, methylenediamine, hexodine, hexodine, hexodine sulfate, hexodine, histamine phosphate, histidine, histoplasmosis, histrelin, histrelin acetate, homatropine hydrobromide, huquinazine hydrochloride, human chorionic gonadotropin, human growth hormone, hydantoin, hydralazine hydrochloride, hydralazine Polistirex, hydrochlorothiazide, hydrochloride Tartaric acid, hydrocortisone, hydroflumethiazide, hydromorphone hydrochloride, hydroxyamphetamine hydrobromide, hydroxychloroquine sulfate, orphenamate, hydroxycaproic acid, hydroxyurea, hydroxychloroquine hydrochloride, hydroxymethylcoumarin, scopolamine, hyperforin, ibafoxacin, ibandronate sodium, ibogaine, ibopamine, ibudilast, ibufenac, ibuprofen, ibutilide fumarate, icatibant acetate, ichthyol, icatidine, idarubicin, idoxifene, herpes, idemenone, ifetroban, ifosfamide, Ilepeimid e, illimaquinone, imofosine, ilomastat, ilodapol, iloperidone, iloprost, benzimidazole hydrochloride, imatinib, imidazoacridone hydrochloride, imidapril, imidazenil, imidazoacridone, imidazoacridone, imidazoacridone hydrochloride, imidazoacridone hydrochloride, imidazoacridone hydrochloride, imidazoacridone hydrochloride, imidazoacridone hydrochloride, imidazoacridone hydrochloride, imidazoacridone hydrochloride, imidazoacridone hydrochloride, imidapenem, imipramine hydrochloride, imiquimod, impromidine hydrochloride, indapamide, indacanib hydrochloride, indopamine hydrochloride Qin, indigo carmine sodium, indinavir, indinavir sulfate, indocyanine green, indopril hydrochloride, indolidan, indomethacin, indomethacin sodium, indoprofen, indolaamine, indole ester hydrochloride, indoxor, indole hydrochloride, infliximab, inotropol, inogatran, inomomab, inositol nicotinate, insulin, interferon, interleukin, indole tetrazole, introtiline hydrochloride, iodobenzylguanidine, iodobenzyl acid, iobimol, iocarmate meglumine, diiodothalamic acid,Iodoxitamide, Iodine, Iodine, Iodoxamid, Iodixanol, Iodoamiloride, Ioantipyrine I 131, Iodocholesterol I 131, Iodoxamicin, Iodohippyric Acid Sodium I 131, Iopiracil I 125, Iodoquinol, Iodoxamie Acid, Iodoxamiic Acid, Iogliic Acid, Iophetamide Hydrochloride I 123, Iotopol, Iodoxamid, Iodoxamid, Iogankamic Acid, Iogulamide, Iohexol, Iomethin I 125, Iopamidol, Iopanoic Acid, Iopentol, Iophenate, Iopsic Acid, Iopromide, Iopromide, Iopridol, Iopyrol, Ioxifamic Acid, Iosilic Acid, Iosulfone Meglumine, Iosuccinic Acid, Iothalamic Acid, Iotoxamiic Acid, Iotoxamiic Acid, Iothalic Acid, Iothalic Acid Sodium, Iotalamic Acid, Iosidet, Iotrolan, Iotroxitamide, Iotyrosine I 131, Ioversol, sodium iodinate, iodixanol, iodixanol, iodixanol, iodixanol, hydroxydiatrizoate, ipalide, iprexazone, ipidacrilin, calcium iodinate, sweet potato bitter alcohol, 4-, ipratropium bromide, ipriflavone, ipridindole, iprofenin, isopronidazole, isoproplatin, iproxamine hydrochloride, ixabepilone, irbesartan, irinotecan, iloxacin, iropra, irsogladine, itimazole, ixastane, ixamoxazol, ipogrelide, isopamicin, isobengazole, aminophenylbutyrate, isocarboxazid, isoconazole, neoproterenol, isof loxythepin, isoflurane, isoflurane, isohomohalicondrin B, isoleucine, isoflurane hydrochloride, isopentamine hydrochloride, isoniazid, isopropylamine iodine, isopropyl alcohol, isopropyl unoprostone, isoproterenol hydrochloride, isosorbide, isosorbide mononitrate, isoquinamide, isotretinoin, isotretinoin, isoxicam, isoxicam, isoxicam hydrochloride, isradipine, itameline, itasetron, itagrel, itopride, itraconazole, ivermectin, jasplakinolide, josamycin, kahalalide F, carafungin, kanamycin sulfate, ketamine, ketanserin, ketazocine, ketazocine, ethoxybutyric acid, fumarate oxyimipramine, ketoconazole, ketoprofen, ketophenone, ketorolac, ketotifen fumarate, kitasamycin, labetalol hydrochloride, lacidipine, lacidipine, lactitol, lativecin, lactobionic acid, lenecon, lafutidine, lamellarin-N triacetate, lamivudine, lamotrigine, lanoconazole, digoxin, lan Pirison, lanreotide, lanreotide acetate, lansoprazole, lapatinib, laropiprant, latanoprost, lateritin, lurasidone, laurocaprol, dodecylisoquinoline bromide, lavotidine succinate, lazabemide, lecithin, leinamycin, lemidipine, lemiprazole, lenasiprazole, lenasiprazole, lenasipril, lenperone, lentinan sulfate, leptin, leptolstatin, lercanidipine, ergonitrile,Lelisetron, letimide hydrochloride, letrazuril, letrozole, leucine, leucomyzin, leuprolide, leuprolide acetate, leuprolide, levosalbutamol, levoamphetamine succinate, levamisole, levodobutamine lactobionate, Leveromakalim, levetiracetam, Leveycloserine, levobetaxolol, levobunolol, levobupivacaine, levocabastine, levocarnitine, levocetirizine, levocetirizine dihydrochloride, levodopa, levodropropizine, levofloxacin, levofuraltazone, levoleucovorin calcium, levoacetylmethadone acetate, salt Levoacetylmethadone acetate, levomoprolol, levonandrodol hydrochloride, levo-isoepinephrine, levonorgestrel, levopropoxyphene, levopropicillin potassium, levomeloxifene, levorphanol tartrate, levosimendan, levosulpride, levothyroxine, levothyroxine sodium, levoxadrol hydrochloride, lexipafan, erythromycin, liazol, lisofenpril, lidamidine hydrochloride, lidocaine, lidofenine, lidofenzine, lifarazine, lifiberol, linarotenol, lincomycin, linear polyamine analogs, linogliflozin, linopyridine, linotroban, linsidomide, lintitript, lintopride, liothyronine 1 125, Iodothyronine sodium, Compound thyroxine, Lisapride, Lissoclinamide dimesylate, Lisinopril, Lissoclinamide 7, Lixazinone Sulfate, Loboplatin, Lobenzarit Sodium, Lobucavir, Chlordraben, Lodoxamide, Lofemazole hydrochloride, Lofentanyl oxalate, Lofepramine hydrochloride, Lofexidine hydrochloride, Earthworm lecithin, Lomefloxacin, Lomerizine, Chlorcarbamide hydrochloride, Lometrexol, Lomonomycin, Lomoxicam, Lomustine, Lonapalene, Lonazolac, Lonidamine, Loperamide hydrochloride, Locarbefol, Bradycepin hydrochloride, Loratadine, Lorazepam, Lorazepam, Locarbamide hydrochloride, Lorenadol, Lopentamide, Lomethazepam, Lornoxicam, Lornoxicam, Chlortalamine, Lochacon, Losartan, Loxatin, Losoantrone, Lothiazine hydrochloride, Loteprednol, Lovastatin, Lovir Amine, loxapine, loxoribine, lubeluzole, lucanthone hydrochloride, rufiloni, lurosetron mesylate, luteotecan, luteinizing hormone, lurasidone, lutetium, luteorelin acetate, melatonin receptor antagonist (luzindole), sodium apoate, aminopalmitamide, lidocin, lidocin, linegestrel, lysine, lysofylline, lysostaphin, lysostaphin, lysopeptide, maduramicin, sulfamethoxazole, bombein 2-amide, magnesium salicylate, magnesium sulfate, magnolol, metansine, polymaleimide, safflower chromone, mallotojaponin, malotiate, malotiate, mangafodipir, manidipine, maniwamycin A, mannitol, mannostatin A, manomycin E, manomycin F, maprastine, maprotiline, maraviroc,Marimastat, dronabinol, maspin, massetolide, maytansine, mazapertine succinate, mazindol, mebendazole, mebeverine hydrochloride, methylbrompheniramine, mebutamate, mecamylamine hydrochloride, nitrogen mustard hydrochloride, meclizine hydrochloride, meclocycline, meclofenamic acid sodium, mecloquinolone, methylclosone dibutyrate, medazepam hydrochloride, medrogestrel, mesalol, medroxyprogesterone, medroxyprogesterone, meclizine hydrochloride, mefenamic acid, mefenamic acid, mefenamic acid hydrochloride, mefenamic acid, salt Mefloquine acid, mefruside, mefloquine potassium dihydrogen phosphate, megestrol acetate, meglumine, megluto, ethinyl estradiol acetate, meloxicam, melphalan, memantine, memodin hydrochloride, mecambinol hydrochloride, menocresol, menolide, follicle stimulating hormone, methoxybenzine sulfate, meparicin, mepentate bromide, meperidine hydrochloride, mefenbutamine sulfate, mephenytoin, mephenytoin, mepivacaine hydrochloride, anning tablets, meptazol hydrochloride, mequindox, mercury sodium, merbarone, mercaptopurine, mercuropheniramine, and ammonia Combined mercury, radioactive mercury propanol Hg197, meropenem, mesalazine, mesilazine, mesoridazine, mesterolone, mestranol, mesulin hydrochloride, metalol hydrochloride, metaprost, metoprolol complex, metaraminol tartrate, metaxalone, methaprost, metformin, methacholine chloride, methacycline, methadone, acetomethadol, methadone, methamphetamine hydrochloride, methaqualone, methazine, methandrine, methenolone acetate, methicillin, methicillin sodium, methimazole, methionine enzyme , methionine, methindoxol, mepenthixol hydrochloride, methocarbamol, methohexital sodium, methoxophene, methotrexate, levomepromazine, methoxatone, mercaptopurine, methoxypolyethylene glycol-erythropoietin beta, methoxyflurane, methsuximide, methylchlorothiazide, methylpamoate, nitrethiatropine, methylbenzethonium chloride, methyldopa, methyldopa hydrochloride, methylene blue, methylergonovine maleate, methylhistamine, methylinosine monophosphate, methylphenidate, methylprednisolone, methyltestosterone, Methynodiol Diacelate, methysergide, methysergide maleate, methionide, metiproline, metipamide, metiprolol, metizolin hydrochloride, mekefamine acetate, metoclopramide, iodine dimethicone, metogest, metolazone, metoprazine, chlorpheniramine, metoprolol, metoquizine, metrifonate, metopramine, metoprazine sodium, metronidazole, metodepa, metyrapone, metyrosine, mexiletine hydrochloride, methylpregnenol propionate potassium, mezlocillin, mianserin hydrochloride, mibefradil, mibefradil dihydrochloride, mibolone, michellamine B, daktarin, microcolin A. Midaflutol, midazolam hydrochloride, midodrine, mifepristone, mifolate, miglitol, milacetamide, milamerine, midronate, milenperone, miliperine, milnacipran, milrinone, miltefosine, mimbene hydrochloride, minapristin, minoxolone, minolamide,minocycline, minocycline, minoxidil hydrochloride, miflukine hydrochloride, mikamycin, mipraside, mifentanil, milistin, milinomycin hydrochloride, milistron maleate, mirtazapine, misonidazole, misoprostol, mibutidamide, mitoxine, mitomycin, mitoxantrone, mitoxantrone, dibromodole, mitomacin, mitomycin, mitonadamide, mitospe, mitotane, mitoxantrone, mivacurium, mivacycline, mixanpril, mixidine, mizolastine, mizoribine, moclobemide, modafinil, modaline sulfate, modicanilide, moexipril, mofaratin , mofegiline hydrochloride, mofezolic acid, morlastin, molinazone, molindone hydrochloride, molsidomine, furoic acid, monapir maleate, monensin, glyceryl caprylate and glyceryl caprate mixture, montelukast, montelukast sodium, monterelin, mopidarol, moricizine, morantel tartrate, moricizine, morphine, sodium morrhuate, mosapramine, mosapride, motilide, moretine, latamoxef disodium, moxazosin, moxifloxacin, moxipril, monidazole, moxonidine, mumps skin test antigen, mozolomide, mycaperoxide B、Mycophenolate mofetil, mycophenolic acid, myriaporone, cannabinoid, nabilone, cannabinoid hydrochloride, cannabinoid hydrochloride, nabumetone, N-acetyldinaline, Nadide, nadifloxacin, nadolol, nadroparin calcium, nafadoxor, nafamostat, nafarelin, nafcillin sodium, nafolpine, namidone hydrochloride, nafecort, naphtholamine malate, nafoxidine hydrochloride, naphthiocarbamide oxalate, naftifine hydrochloride, naftopidil, nagrestip, nalbuphine hydrochloride, Nalidixate Sodium, nalidixic acid, nalmefene, naloxone hydrochloride, naloxone, naltrexone, nalmoretide, nandrolone phenylpropionate, naldrol hydrochloride, napatadine hydrochloride, naphthalene disulfonate, nepamizole hydrochloride, napaviin, naphazoline hydrochloride, naphterpin, naproxen, naproxen sodium, napxol, nesagatran, nalanol hydrochloride, methyl narasin, naratriptan, natograstim, nasaplase, natalizumab, natamycin, nateplase, nagolide hydrochloride, nebivolol, niramycin, nedaplatin, nedocromil, nefazodone hydrochloride, nefluzide hydrochloride, nefopam hydrochloride, naproxen maleate Lezalin, Nemazoline Hydrochloride, Nemorubicin, Neomycin Palmitate, Neostigmine Bromide, Neridronic Acid, Netilmicin Sulfate, Neutramycin, Neyirapin, Nesiridin Hydrochloride, Nicotinic Acid, Nibrosan, Nicardipine Hydrochloride, Nicergoline, Niclosamide, Nicorandil, Nicotinamide, Nicotanol, Nifedipine, Nifirmerone, Niflurid, Nifuradine, Nifuradine, Nifuroxine, Nifuratel, Nifuron, Nifurdazide, Nifurtamide, Nifuranolol, Nifurtimox, Nilotinib, Nilotinib Hydrochloride Monohydrate, Nilutamide, Nilvadipine, Nimazone, Nimodipine,Nipertidine, Nilavorine, Niridazole, Nisamycin, Nisasterol mesylate, Nisodil, Nisodil, Nisoldipine, Nisoxetine, Androxyl acetate, Niphenylarsonic acid, Nitazoxanide, Niticapine, Nitrofuran hydrochloride, Niramine hydrochloride, Niramidazole hydrochloride, Nitrazepam, Nitrendipine, Nitrocydine, Nidan, Nitrofurantoin, Nitrocilin, Nitroglycerin, Nitrocresol mercuric, Nitamide, Nimifen citrate, Nitrous oxide, Nitrous oxide antioxidant, Nitrullyn, Nivacol, Bimetrin sodium, Nizatidine, Norbotin, Nobifensine, Noramycin, Norlimium bromide, Nomifensine maleate, Nomexadol hydrochloride, Diethylsedrine, Norepinephrine tartrate, Norethisterone, Isoacetyl Norfloxacin, Norfiurane, Norfloxacin, Norgestimate, Norgestrel, Norgestrel, Nortriptyline hydrochloride, Noscapine, Nilestradine, Neomycin, Nystatin, Bisphosphonate, Ocapidone, Ofentanil hydrochloride, Osipron, Caprylic acid, Octamidine, Octenidine hydrochloride, Octodrine, Octreotide, Octetrine phosphate, Ofloxacin, Ofenamide, Octenidine hydrochloride, Otodrine, Octreotide, Octetrine phosphate, Ofloxacin, Ofenamide, Okicenone, Olanzapine, Oligonucleotide, Olopatadine, Olprinone, Olsalazine, Olsalazine sodium, Ovanil, Omeprazole, Onapristone, Ondansetron, Onzolast, Oocyte maturation inhibitor, Opipramol hydrochloride, Oracin, Oconazole nitrate, Ogutin, Orlislat, Omaplatin, Omeprazole, Opanopram, Opanosin, Ophenazone citrate Jun, Oshatron, Oseltamivir, Otenzhepa, oxacillin sodium, oxagrelate, oxaliplatin, oxacoumarin hydrochloride, oxamiso, oxaniquine, oxandrolone, octadalafil pamoate, hydroxyprotriptyline hydrochloride, oxaprozin, oxabazole, oxamide, oxaunomycin, oxazepam, oxcarbazepine, oxandolone, ethoxyzine, oxitolone fumarate, oxfendazole, hydroxyphenylglycine, oxibendazole, oxiconazole, hydroxydopamine, oxyphosphodiesterase, oxyfungin hydrochloride, oxymorphone, oximemonam, oximemonam sodium, opimide, oxiracetam, oxylamidin, oxysulam, ometidine hydrochloride, oxodipine, oxyprogesterone phenylpropionate, oxolinic acid, oxprenolol hydrochloride, theophylline, oxybutynin chloride, oxyclosan, oxycodone, Oxycodone hydrochloride, oxymetazoline hydrochloride, oxymetholone, oxymorphone hydrochloride, oxepertine, hydroxybutazone, allopurindiol, oxytetracycline, oxytocin, ozagrel, ozolinone, paclitaxel, palauamine, padromycin, palinavir, palivizumab, palmitoylrhizoxin, sodium pamoxate, pamaside, pamarol sulfate, pamigre, pamidronate disodium, pamidronate, panacipron, panamexin, panaxytriol, pancopride, pancuronium, panipenem, pannorin, panomifen, pantethine, pantoprazole, papaverine hydrochloride, parabactin, parachlorophenol, paraldehyde, paramethasone acetate, renitolin hydrochloride, parapentyl bromide, pamoic acid parafumarate,Parbendazole, parconazole hydrochloride, compound camphor tincture, parite sulfate, pargyline hydrochloride, parite sodium, paromomycin sulfate, paroxetine, paroxetine hydrochloride, parthenolide, partricin, paclomycin, pazeptine, paquinclone, pazoxetine, pazufloxacin, pefloxacin, pegaspargase, pegotin, perlanserin hydrochloride, perdecin, perrimycin, pegretinoic acid, perrinone hydrochloride, pemetrexed, pemirolast, pemoline, penacillin , Penbutolol sulfate, Penciclovir, Penfluridol, Penicillamine, Penicillin G benzathine, Penicillin G potassium, Penicillin G procaine, Penicillin G sodium, Penicillin V, Penicillin V benzathine, Penicillin V hydrilamine, Penicillin V potassium, Pentamidine, Pentaerythritol tetranitrate, Pentafusil, Pentamidine, Pentomorph, Neostigmine bromide, Pentazocine, Triaminepentaacetic acid, Pentothiapine maleate, Pentegitide, Pentamicin, Pentothiazolinone sodium, Pentobarbital, Pentothiomande, Pento Toprol, pentosan, pentostatin, pentoxifylline, pentanoate, pentrozole, peplomycin sulfate, pepstatin, perflubromethane, perfofamide, perfosfamide, pergolide, perhexiline maleate, perillyl alcohol, perindopril, perindoprilat, Perlapine, Permethrin, Perospirone, perphenazine, phenylacetamide, phenaridine, phenazinomycin, nadazole hydrochloride, phenylbutazone sodium glycerol, phencarbamide, phencyclidine hydrochloride, phendimetrazine tartrate, phenethylhydrazine sulfate, phenformin, phenmetrazine hydrochloride, phenobarbital, phenoxybenzamine hydrochloride, phenprocoumon, phenserine, phensuccinal, phensuximide, phentermine, phentermine hydrochloride, phentolamine mesylate, Phentoxifylline, phenylaminosalicylic acid, phenylacetic acid, phenylalanine, phenylalanyl ketoconazole, phenylbutazone, phenylephrine hydrochloride, phenylpropanolamine hydrochloride, phenylpropanolamine Polistirex, pheniradoline hydrochloride, phenytoin, phenytoin sodium, physostigmine, mepropofol, bisibanib, diethanolamine picolinate, picornaline, pikuterol, pidomed, pifarmine, pilocarpine, pilsicainide, pimagedin, pimetin hydrochloride, pimiprost, pimobendan, pimozide, pinacidil, pinadol, pindolol, pinnenol, pinocebrin, hydrochloride Piperoxine, Pioglitazone, Pipanperone, Pipazolate, Picuronium, Piperacillin, Piperacillin Sodium, Piperamide Maleate, Piperazine, Pipobroman, Piposufan, Pipothiazine Palmitate, Pipoxol Hydrochloride, Piprazoline, Piquantel Hydrochloride, Piperaquine, Piperaquine Hydrochloride, Piracetam, Piradamine Hydrochloride, Pirarubicin, Piramonan Sodium, Pirazolic Acid, Pibecillin Sodium, Pibuterol Acetate, Piramperone, Pirenzepine Hydrochloride, Piretanide, Pirfenidone, Piridacillin Sodium, Piridronate Sodium, Pirprostaglandin,Piroxine, piromexin hydrochloride, piroxetine, pirmogrel, pirmenol hydrochloride, tetramethylpyraclostrobin, hydroxymethylpyraclostrobin, pirodavir, pirrolast, piroglide tartrate, piroclide, pyraclostrobin, piroxantrone hydrochloride, piroxicam, piroxetine, pirprofen, piquinolones, pyridoxine, piromexin hydrochloride, piroxetine, piroxidine, placetin A, plicamycin, plometane, polibilast ethylenediamine, podafilox, Pacific Rhus extract, boldine methylsulfate, polyglucosamine, poliglucosidase sodium, polymyxin B sulfate, polythiazide, ponastat, porfil sodium, porfiromycin, potassium chloride, potassium iodide, potassium permanganate, povidone iodine, pralolol, pralidoxime, pramipexole, pramiracetam hydrochloride, pramoxime hydrochloride, pralidoxime chloride, pradolin maleate, pravastatin, pravastatin sodium, prazepam, prazosin, prazosin hydrochloride, prenazate, prednicarbate, prednimustine, prednisone, prednisolone, quetiapine fumarate, prednisone, prednisolone valerate, pregabalin, Pregnenolone succinate, pricaterol hydrochloride, prenylamine, pridilidine hydrochloride, produlacid, profadol hydrochloride, progamide, pridifen hydrochloride, prifilone, prilocaine hydrochloride, omeprazole, primaquine phosphate, primilol, primidone, lisinopril, primidone tromethamine, prinosodan, pritosufloxacin, prizidol hydrochloride, profadol hydrochloride, probenecid, pruclomiphene calcium, probucol, procainamide hydrochloride, procaine hydrochloride, methylbenzalazine, procaterol hydrochloride, prochlorperazine, pricinone, prochlorperanol, procyclidine hydrochloride, pridilidine hydrochloride, produlacid, profadol hydrochloride, halogen, Progesterone, Proglumide, Proinsulin (human), Proline, Prolintan Hydrochloride, Promazine Hydrochloride, Promethazine, Promethazine Hydrochloride, Propafenone Hydrochloride, Propagermanium, Propanidene, Propantheline Bromide, Proparacaine Hydrochloride, Propatyl Nitrate, Propentyltheoyl, Cyclofenac Hydrochloride, Propicacin, Propionylmazine, Propionic Acid, Propionylcarnitine, L-, Propiram, Propiram + Paracetamol, Propiverine, Propofol, Proponolol Hydrochloride, Propoxycaine Hydrochloride, Propoxyphene Hydrochloride, Propranolol Hydrochloride, Cisapride, Propyl Diacridone, Propylhexedrine, Propidoline, Propylthiouracil, Proquinezone, Propionic Acid Potassium, promethazine hydrochloride, scutellum glycoside, prostaglandin, prostratin, protamine sulfate, endogenous antimicrobial peptides, prorelin, protriptyline hydrochloride, proxazole, proxazole citrate, proxilamide, promorphan tartrate, prulifloxacin, pseudoephedrine, pseudoephedrine hydrochloride, puromycin, pyrabunone, pyrantel pamoate, pyrazinamide, pyrazomycin, pyrazoline acridine, pyridostigmine, pyridoxine hydrochloride, trimethoprim maleate, pyrimethamine, pyrrolidine, sodium pyrithione, zinc pyrithione, pyrovalerone hydrochloride, pyrroloxamine maleate, pyrocaine, pyrrolpheniramine hydrochloride, pyrrolnitrin, pyrimidine, quadazocine mesylate,Quazepam, Quinazidone, Quazodine, Quinazolidone, Quetiapine, Quetiapine Fumarate, Quinflapone, Quinagolide, Quinadin Blue, Quinapril, Quinapril Hydrochloride, Quinazosin Hydrochloride, Quibolone, Quinctolate, Quindicamine Acetate, Quinodilium Bromide, Quinolone Hydrochloride, Ethinyl Esternol, Quinfamide, Quingestrol Acetate, Quingestrol Gluconate, Quinielorane Hydrochloride, Quinine Sulfate, Quinpirole Hydrochloride, Quinopristine Sulfate, Quinupristin, Quinopristine Maleate, Rabeprazole, Rabeprazole Sodium, Racemic Thiamphenicol, Racemic Epinephrine, Rafoxanide, Ralitoline, Raloxifene, Raltegravir, Rafaxanide Titrexed, Ramatroban, Ramipril, Ramoplanin, Ramosetron, Ranelic acid, Ranimycin, Ranitidine, Ranitidine hydrochloride, Ranolazine, Rauwolfia alkaloid, Recanam, Recanam hydrochloride, Reclozepam, Recombinant Factor VIII, Rigavir, Relastim, Relaxin, Rilomycin, Remacemide hydrochloride, Remifentanil hydrochloride, Reprostenol, Remopril, Repirasta, Repremicin, Reproterol hydrochloride, Reserpine, Resferatoxin, Resorcinol, Retapamulin, Demethyl Reteptine, Reticulon, Reviparin sodium, Revizinon, Rhenium etidronate sodium, Genomycin, RII retinamide, ribamino, ribavirin, riboadenosine, licarsetron, lidogrel, rifabutin, riformestane, rifaxixi, rifatomide, rifampicin, rifapentine, rifaximin, rilopiride, riluzole, rimantadine, lincarazole hydrochloride, rimexolone, rimaterol hydrobromide, rimonabant, rimurogin, riodipine, rioprostil, ripazepam, ripisartan, risedronate sodium, risedronate sodium, risedronic acid, risocaine, risolite hydrochloride, rispentzepine, risperidone, risperidone, ritanserin, ritopenem, ritodrine, ritonavir, ritonavir, rivastigmine, rivastigmine tartrate , rizatriptan, rizatriptan benzoate, rocastine hydrochloride, rocuronium, rhodocaine, roflurane, rhodoxamine, rohitukine, rotamycin, Roletamicide, rogamidine, roliprin, rolipram, rolicycline, rolodine, clomazalide, romotide, ronidazole, ropinirole, ropitol hydrochloride, ropivacaine, ropizine, roquimec, roxamicin, rosiglitazone, rosiglitazone maleate, rosofloxacin, rosuvastatin, rotavirus vaccine, rotigotine, rotoxamine, roxaitidine, roxasane, roxithromycin, rubiginone B1, ruboxyl, rufloxacin, rupatidine, rutamycin, luzadol, sabelouzole, safingol, safilonide, saintopin, salbutamol, salbutamol sulfate, salicylate, diethylaminoethyl salicylate, salicylic alcohol, salicylamide, meglumine salicylate, salicylic acid, salmeterol, sanacidin, salsalate, sammelidine, sanpatraz, sancycline,Sanfepenem, Sanguinarium Chloride, Saconazole, Prisartan, Sapropterin, Sapropterin Hydrochloride, Saquinavir, Sarafloxacin Hydrochloride, Sapropterin, Phytol A, Sargramostim, Samocillin, Sapicillin, Sagrelide, Saruplase, Satrinone, Satigre, Satumomab Pendetide, Secofungin, Scopolamine Hydrobromide, Scrazaipine Hydrochloride, Secalcitol, Secobarbital, Seelzone, Seglitide Acetate , selegiline, selegiline hydrochloride, selenium sulfide, selenomethionine selenium-75, sefortai, semlide, semdomicin, semodiol, semustine, trifenazol chloride, haloperidol hydrochloride, spriligy, seroxetine hydrochloride, selacotide acetate, ergoxol maleate, serine, semethacin, sermorelin acetate, sertaconazole, sertindole, sertraline, septiline, stopirone, sevelamer, sevirumab, sevoflurane, sezo Amine, sibotridine, sibutramine hydrochloride, signal transduction inhibitors, silanolone, silipide, ceteplasmase, silver nitrate, simendan, simtraqin, simvastatin, sincalide, cinefinin, cinediol, sinnabidol, ciprazol, rapamycin, sisomicin, sitagliptin, cimetropium glycoside, sizolan, sobuzosine, sodium nitroprusside, sodium iodide 1-123, sodium nitroprusside, sodium oxybate, sodium phenylacetate, sodium salicylate, propionate Sodium valerate, solifena, solverol, soripertin tartrate, porcine alanine somatotropin, somantine hydrochloride, somatomedin B, somatomedin C, somatostatin, human methionine somatotropin, growth hormone, porcine nosocomial growth hormone, bovine somatotropin, sobinir, sorivudine, sotalol, soterol hydrochloride, sparfloxacin, sodium acetylaspartate, fospartic acid, sparmycin, spartin sulfate, spectinomycin hydrochloride, spicamycin D, spiperone, spirodolin mesylate, spiramycin, spirapril hydrochloride, spirapril, spirogermanium hydrochloride, spiromustine, spironolactone, spiromolybdenum, spiroxazone, splenopentin, spongistatin 1. Dysprosium diamide, squalamine, stamycin hydrochloride, stannous pyrophosphate, tin sulfur colloid, stanozolol, stolon, staurosporine, stavudine, stamycin, stenbolone acetate, stironine, stironium iodide, stilol iodide, stipiamide, stiripentol, stobadine, streptomycin sulfate, streptomycin isonicotinohydrazine, streptozotocin, streptozotocin, strontium chloride Sr-89, succibun, succimer, succinylcholine chloride, Sucralfate, sucralfate potassium, sudoxicam, sufentanil, sufotidine, thiazepam, sulbactam ester, sulfaconazole nitrate, sulfabenzene, sulfadiazine, sulfacetamide, sulfaethycin, sulfadiazine, sulfadoxine, sulfamethoxazole, sulfamethoxazole, sulfamethoxazole, sulfamethoxazole, sulfadiazine, zinc sulfadiazine, sulfanilate, sulfasalazine, sulfisothiazole, sulfapyrazole, sulfadiazine hydrochloride,sulfinosine, sulfinpyrazone, sulfisoxazole, sulfinocysteine, sulfinocysteine, sulfinocysteine, sulfoterol hydrochloride, sulfoxamine, Sulinldac, sulfomaline, sulnidazole, suloprene, sulfonylurea, sulfopenem, suloxifene oxalate, sulpride, sulprostone, sultamicillin, sultamimet, sultopride, sulforust, sumarotene, sumatriptan, sumatriptan succinate, sencillin sodium, sulprotone, suprofen, suradista, suramin, suform, sulcap, sulikanid maleate, sulitazole, sulocysteine ​​maleate, succinyl sulfate, succinyl sulfate, swainsonine, symakalim, chloroxytriazine, simetine hydrochloride, taciamine hydrochloride, tacrine hydrochloride, tacrolimus, tadalafil, talampicillin hydrochloride, levocyclotetraconol, talimycin, tamustine, Tametacin, talniflumate, talopram hydrochloride, talosalate, tametraline hydrochloride, tamoxifen, tamoxifen citrate, tampamine fumarate, tamsulosin, tamsulosin hydrochloride, tandamine hydrochloride, tandospirone, tapgen, taprostene, tasosartan, iodomustine, taxane, Taxoid, tazadolin succinate, tazalast, tazarotene, taziphylline, taziphylline hydrochloride, tazobactam, tazofilone, tazoprodolol hydrochloride, terbufilone, tibuquine, teclozan, tecogalan sodium, teecleukin, teflon, tegafur, tegaserod, carbamazepine, teicoplanin, telenzepine, tellurapyrylium, temestan, telmisartan, teloanthrone hydrochloride, tiludipyrine hydrochloride, temafloxacin hydrochloride, tematropium Methyl sulfate, temazepam, temestine, temocapril, temocillin, temoporfin, temozolomide, temsirolimus, tenidapol, teniposide, tenofovir, tenosalu, tenoxicam, tipindole, tepoxaline, teprotide, terazosin, terazosin hydrochloride, terbinafine, terbutaline sulfate, terconazole, terfenadine, terf iavoxate, terguride, teriparatide, teriparatide acetate, terakiren, terlipressin, terodiline, terozalin hydrochloride, teroxirone, tertalol, texicam, benzylisoquinone, testosterone, testosterone, tetracaine, tetrachlorodecaoxide, tetracycline, tetracycline hydrochloride, tetrahydrozoline hydrochloride, tetramisole hydrochloride, meglumine tetrazolast, tetrazomine, tetrofosmin, tetrahydroxyquinone, Tetraoxaprine, tetrahydromethinamide, mycelium embryos, thalidomide, edoxaban, theophylline, thiabendazole, thiamethoxazole, thiopentol, thiamobarbital, thiamethoxazole hydrochloride, ThiazinamiumChloride, Thiethylperazine, Sodium thiomercurate, Thimerosal, Thioctadecanoic acid, thioguanine, thiomarinol, thiopental sodium, thioperamide, thioridazine, thiotepa, bisphenylethylthioate hydrochloride,ThiphencillinPotassium, Thiram, Tozalone, Threonine, Thrombin, Thrombopoietin, Thymosin, Thymopentin, Thymosin, Thymidone Hydrochloride, Thyroxine, Thioxastar, Thioxastar Sodium, Tiagabine, Thiamidine, Tianeptine, Tiapafant, Tiapamil Hydrochloride, Thiaramide Hydrochloride, Thiazole Carboxamide Nucleoside, Thioxastar Sodium, Tibolone, Tifibric Acid, Ticarbesone Propionate, Ticarbodine, Ticarcillin Sodium, Ticlatone, Ticlopidine, Tinimic Acid, Tenolol, Tifurate Sodium, Tigemonam Dicholine, Tigestrol, Tiletamine Hydrochloride, Tildronic Acid, Tilidine Hydrochloride, Tilirolol, Tiprofen Amate, Tiloron Hydrochloride, Tiludronate Disodium, Tiludronate, Timet furone, timobesone acetate, timolol, timolol maleate, cannabinol, tinidazole, tinzaparin sodium, tioconazole, thiodazosin, clobenthiodine chloride, thioperidone hydrochloride, thiopinic acid, tispirone hydrochloride, thiotidine, tiotropium bromide, thiaxetine, thiaxetine hydrochloride, tipranavir, tipredan, tipridil hydrochloride, tiquen, tirandalydigin, tirapazamine, tirazad, tirofiban, cinamide, titanocene dichloride, thiocobalt iodide ... tolmetin, tolnaftate, iodobenzyl polyvinyl pyrrolidone, tolsulfuronamide, toristastat, tolterodine, tolterodine tartrate, tolukast, atomoxetine hydrochloride, tonarzocin mesylate, topiramate, topotecan, topotecan hydrochloride, topsentin, toprosterone, toquizine, torasemide, toremifene, torasemide, tosifen, tofloxacin, totipotent stem cell factor, tracazolate, trefermine, trolonide, tramadol hydrochloride, tramazoline hydrochloride, trandolapril, tranexamic acid, tranilast, troscainide, translation inhibitor, traxanol, trazodone hydrochloride, trazodone hydrochloride, trebenzoamine hydrochloride, trefentanyl hydrochloride, troloxetine, tripipan maleate, triptolon acetate, retinoic acid, triacetin, triac etyluridine, triazine fungin, triamcinolone acetonide, triamcinolone sulfate, triamterene, triazolam, tribene glycoside, tricaprilin, trimethoxyphenyl ester amide, trichlorothiazide, hair transparent protein, triciribine, Tricitrates, trichlorophenpiperazine, triclofosin sodium, trientine, triphenylglycan, triflavin, trifluroxine, triflubazam, triflumidate, trifluoperazine hydrochloride, trifluperidol, triflupromazine, triflupromazine hydrochloride, trifluridine, benzhexyphenidyl hydrochloride, trilostane, trimazosin hydrochloride, trimegestone, alimamazine tartrate, trimethoprim, thiophene camphor sulfonate, trimethoprim, trimetozin, trimetoxazine, trimeprazine, trimipramine, trimoprost, trimoxamine hydrochloride, triolein,Trivoxifene mesylate, tripamide, tripelennamine hydrochloride, triprolidine hydrochloride, triptorelin, trisulfuron, troclosan potassium, troglitazone, triethanolamine, troleandomycin, trombodipine, tromethamine, tropaneserin hydrochloride, tropicamide, scopolol, tropisetron, spectinomycin, trovafloxacin, troviridine, tryptophan, tuberculin, tubocurarine chloride, tobradazole hydrochloride, tucarcsol, tulobuterol, tolosan, tadalafil, tylogenin, piropec sodium , tyrosine, tyrphostins, ubenimex, udazepam, undecylenic acid, uramustine, urapidil, urea, uredepa, uridine triphosphate, urofollicle-stimulating hormone, urokinase, ursodeoxycholic acid, valacyclovir, valacyclovir hydrochloride, valine, valproic acid semisodium, valproic acid, valsartan, vamipril, vanadeine, vancomycin, vaninolol, valperprost hydrochloride, vapreotide, vardenafil, varenicline, variolin B. Vasopressin, vecuronium, vilaresol, vilacridine maleate, venlafaxine, venlafaxine hydrochloride, viladol hydrochloride, verastat, verapamil hydrochloride, verdins, vililopam hydrochloride, vilukast, verofylline, veroxan, verteporfin, vesirinone, vexibinol, adenosine, vigabatrin, vildagliptin, viloxazine hydrochloride, vinblastine sulfate, vinbutine citrate, vinfosinate, vincristine sulfate, vindesine , vindesine sulfate, vinpoidine sulfate, vindesine sulfate, vinorelbine sulfate, vinorelbine, vinpocetine, vinpocetine, vinxaltine, vinorelbine sulfate, viroprostenol, virginia, viroxiflavone, viroxime, vitaxin, voglibose, vorazocine, voriconazole, vorozole, vorgolide, warfarin sodium, xamoterol, xanthate, sodium isopropyl oxanate, xanthinol nicotinate, zemilofiban, bifenazine, bifenbutic acid, xiloban , ximoprofen, xipamide, zolphanol mesylate, xylamidine p-toluenesulfonate, xylazine hydrochloride, xylometazoline hydrochloride, xylose, yangambin, zabipril, zacopril, zafirlukast, zalcitabine, zaleplon, zaspironone, zotidine hydrochloride, zaltoprofen, zanamivir, zankiren, zanotron, zatek, zatebradine, zatebradine, zatosetron, zatosetron maleate, zenastat, zelesoxine mesylate, zeniplatin, zenetoxine Mycophenolate mofetil, zidovudine, zilosilane, zilantel, benzylvitamin C, zileuton, zimeldine hydrochloride, zinc undecylenate, azithromycin, zinoconazole hydrochloride, jingsistatin, jingterol hydrochloride, jingwei oxime, ziprasidone, Zobolt, zofenopril calcium, zofenoprilat, zolamin hydrochloride, zolazepam hydrochloride, zoledronate, zoletin hydrochloride, zolmitriptan, zolpidem, zomepirate sodium, clofenazol, zoniclozole hydrochloride, zonisamide, zopiclone, zopolrestat, zolbermycin,Zorubicin hydrochloride, Zotepine, and Zhukasaixin.

[0166] Another acceptable pharmaceutical active for use herein is lumateperone, as described in U.S. Pat. Nos. 9745300, 9708322, 7183282, 7071186, 6552017, 8648077, 8598119, 9751883, 9371324, 9315504, 9428506, 8993572, 8309722, 6713 471, 8779139, 9168258, RE039680E1, 9616061, 9586960 and disclosed in U.S. Patent Publication Nos. 2017114037, 2017183350, 2015072964, 2004034015, 2017189398, 2016310502, and 2015080404, the contents of which are incorporated herein by reference in their entirety.

[0167] Other examples of antidiabetic active substances include, but are not limited to, JTT-501 (PNU-182716) (Reglitazar), AR-H039242, MCC-555 (Netoglitazone), AR-H049020 (Tesaglitazar), CS-011 (CI-1037), GW-409544×, KRP-297, RG-12525, BM-15.2054, CLX-0940, CLX-0921, DRF-2189, GW-1929, GW-9820, LR-90, LY-510929, NIP-221, NIP-223, JTP-20993, LY 29311Na, FK614, BMS298585, R 483, TAK 559, DRF 2725 (Ragaglitazar), L-686398, L-168049, L-805645, L-054852, Demethyl asteriquinone (L-783281), L-363586, KRP-297, P32 / 98, CRE-16336 and EML-16257.

[0168] The dosage forms of the present invention may include a variety of drugs, biologically active substances and pharmaceutical compositions. Examples of useful drugs include angiotensin converting enzyme inhibitors, antianginal drugs, antiarrhythmic drugs, antiasthmatic agents, antihypercholesterolemic drugs, analgesics, anesthetics, anticonvulsants, antidepressants, antidiabetic agents, antidiarrheal preparations, antidotes, antihistamines, antihypertensives, anti-inflammatory agents, antilipid agents, antimanic agents, antiemetics, antistroke agents, antithyroid preparations, antitumor drugs, antiviral agents, acne drugs, alkaloids, amino acid preparations, antitussives, antihyperuricemia drugs, antiviral drugs, anabolic agents, preparations, systemic and non-systemic anti-infective agents, anti-neoplastic agents, anti-Parkinson's disease agents, anti-rheumatic agents, appetite stimulants, biological response modifiers, blood regulators, bone metabolism regulators, cardiovascular agents, central nervous system stimulants, cholinesterase inhibitors, contraceptives, decongestants, dietary supplements, dopamine receptor agonists, endometriosis control agents, erectile dysfunction treatment agents, fertility agents, gastrointestinal agents, homeopathic agents, hormones, hypercalcemia and hypocalcemia control agents, immunomodulators, immune Depressants, migraine preparations, motion sickness treatments, muscle relaxants, obesity control agents, osteoporosis preparations, oxytocin, parasympathetic agents, parasympathomimetics, prostaglandins, psychotherapeutic agents, respiratory agents, sedatives, smoking cessation aids, sympathetic blockers, tremor preparations, urinary tract agents, vasodilators, laxatives, antacids, ion exchange resins, antipyretics, appetite suppressants, expectorants, anxiolytics, antiulcer agents, anti-inflammatory substances, coronary vasodilators, cerebral vasodilators, peripheral vasodilators agents, antipsychotic agents, stimulants, antihypertensives, vasoconstrictors, migraine therapeutics, antibiotics, tranquilizers, antipsychotics, antineoplastics, anticoagulants, antithrombotics, hypnotics, antiemetics, antinausea agents, anticonvulsants, neuromuscular agents, hyperglycemic and hypoglycemic agents, thyroid and antithyroid preparations, diuretics, antispasmodics, uterine relaxants, antiobesity agents, erythropoiesis stimulating agents, antiasthmatic agents, cough suppressants, mucolytics, DNA and genetically modified drugs, and combinations thereof.

[0169] Controlled release dosage form

[0170] The term "controlled release" is intended to mean releasing the active substance at a preselected or desired rate. The rate will vary depending on the application. Desirable rates include rapid release or immediate release profiles as well as delayed release, sustained release, or sequential release. Combinations of release patterns are contemplated, such as an initial spike release of the active substance followed by a lower level of sustained release. Pulsatile drug release is also contemplated.

[0171] The polymer selected for the dosage form of the present invention may also be selected to allow disintegration of the active substance. This can be achieved by providing a substantially water-insoluble film that binds the active substance that will be released from the dosage form over time. This can be achieved by incorporating a variety of different soluble or insoluble polymers, and may also include combinations of biodegradable polymers. Alternatively, the coated controlled release active substance particles may be incorporated into a readily soluble film matrix to achieve controlled release characteristics of the active substance within the digestive system when taken.

[0172] Films that provide controlled release of active substances are particularly useful for buccal, gingival, sublingual and vaginal applications. The films of the present invention are particularly useful in the presence of mucous membranes or mucous fluids because they can readily wet and adhere to these areas.

[0173] For a long time, it has been recognized in the pharmaceutical field that the convenience of applying a single dose of medicine is that it releases the active ingredient in a controlled manner over an extended period of time compared to applying multiple single doses at regular intervals. The advantages of having consistent and unified blood levels of the drug over an extended period of time are also recognized for patients and clinicians. The advantages of various sustained-release dosage forms are well-known. However, the preparation of a film that provides controlled release of an active substance has other advantages in addition to the well-known advantages of a controlled-release tablet. For example, since the film does not need to be swallowed like a tablet, the film is difficult to be inadvertently sucked out and provides improved patient compliance. Moreover, certain embodiments of the film of the present invention are designed to adhere to the buccal cavity and the tongue, where the film is controllably dissolved. In addition, the film cannot be crushed in the manner of a controlled-release tablet, which is a problem that causes abuse of drugs (such as OxyContin).

[0174] The active substances used in the present invention can be incorporated into the film or other dosage form compositions of the present invention in a controlled release form. For example, the drug particles can be coated with polymers such as ethyl cellulose or polymethacrylates, which are commercially available under trade names such as Aquacoat ECD and Eudragit E-100, respectively. Drug solutions can also be absorbed onto such polymer materials and incorporated into the film compositions of the present invention. Other components, such as fats and waxes, and sweeteners and / or flavorings can also be used in such controlled release compositions.

[0175] As described in U.S. Patent Application Publication No. 2007 / 0281003, entitled "Polymer Based Films and Drug Delivery Systems Made Therefrom," the active agent may be taste-masked prior to incorporating the active agent into the film composition, which is incorporated herein by reference. Taste-masking the active agent as disclosed herein is described below.

[0176] Taste masking of active ingredients in microgranules

[0177] The active agent adopted in the present invention is incorporated into the film composition of the present invention in the form of taste masking or controlled release. Taste masking can be used to avoid unpleasant taste effects, such as bitter taste, often associated with active agents (such as drugs). In this embodiment, the drug particles can be coated with a taste masking agent, which is, for example, a polymer, oil or wax. In addition, sensory agents, such as but not limited to sweeteners and / or flavorings, can also be used in such compositions through taste masking, and are included in the coating layer of the taste masking agent. In alternative embodiments, the particle coating imparts controlled release, delayed release or sustained release characteristics, thereby delaying the release of the active agent from the particles in the consumer's oral cavity or intestinal tract.

[0178] The taste-masked or controlled-release particles can be any useful organoleptic agent, cosmetic agent, pharmaceutical agent, or combination thereof. Useful organoleptic agents include flavorings and sweeteners. Useful cosmetic agents include breath fresheners or decongestants, such as menthol, including menthol crystals.

[0179] Compositions employing microparticulate active agents incorporated into films having taste-masking coatings are disclosed in PCT application WO2003 / 030883, entitled "Uniform Films For Rapid Dissolve Dosage Form Incorporating Taste-Masking Compositions," the entire subject matter of which is incorporated herein by reference. As used in this application, any reference to taste masking by coating a microparticulate active agent should also be understood to include controlled release coatings of the microparticulate active agent.

[0180] An important consideration for film-based drug delivery compositions involving controlled release or taste-masked particle technology is that the drug-containing particles remain chemically stable and do not release active drug during the mixing and film-forming operations of the manufacturing process. Therefore, for films formed by wet casting, the controlled release or taste-masked particle composition should be sufficiently stable in the mixer before the film forming step and the casting and drying steps so that the particles remain intact in the finished product. In the hot melt extrusion film manufacturing process, the particles must be stable in the extrusion apparatus and any subsequent steps so that the particles remain intact in the finished product.

[0181] In one embodiment, the taste masking agent or controlled release agent is a film coating on the microparticle bio-effector. Useful coatings in this embodiment include polymeric and non-polymeric materials.

[0182] Non-limiting examples of polymers include acrylic polymers, cellulosic polymers, or vinyl polymers. Non-limiting examples of non-polymeric materials include crown ethers, fully hydrogenated oils and waxes. In addition, the taste masking agent may be water soluble, water insoluble, or partially water soluble.

[0183] For example, the coating material can be carboxymethylcellulose; methylcellulose; ethylcellulose; hydroxymethylcellulose; hydroxyethylcellulose; hydroxypropylcellulose; hydroxypropylmethylcellulose; hydroxymethylpropylcellulose; gum arabic; xanthan gum; tragacanth gum; acacia gum; carrageenan; guar gum; locust bean gum; pectin; alginate; gelatinized, modified or unmodified starch, including tapioca starch, rice starch, corn starch, potato starch and wheat starch; polyvinyl alcohol; polyacrylic acid; polyvinyl pyrrolidone; poly(meth)acrylates; poly(meth) copolymers; dextrin; dextran; proteins, such as gelatin, zein, gluten, soy protein, soy protein isolate and whey protein; whey protein isolate; casein; levin; collagen; chitin; chitosan; polydextrose, and combinations thereof.

[0184] Useful acrylic polymers include those available from America, LLC under the trade name Those available under the trade name Eudragit Eudragit Eudragit and Eudragit Methacrylic acid copolymers sold under the trade name Eudragit Polyethyl acrylate-methyl methacrylate is sold as such. These acrylic polymers are generally water-soluble materials.

[0185] Useful cellulosic polymers include alkyl celluloses such as methyl or ethyl cellulose; and hydroxyalkyl celluloses such as hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, hydroxymethyl propyl cellulose, and combinations thereof. Useful alkyl celluloses include those sold by Dow Chemicals under the trade name Methocel E TM Additionally, useful ethylcellulose is commercially available from FMC Corporation under the trade name Aquacoat ECD. These polymers are generally water-soluble materials.

[0186] In addition, the pharmaceutically active agent can be sprayed and congealed with fully hydrogenated oils or waxes that are considered safe and relatively stable for human consumption. Useful but non-limiting pharmaceutically acceptable oils include mineral oil, peanut oil, soybean oil, sunflower oil, corn oil, olive oil, hard palm oil, and rapeseed oil.

[0187] In addition, crown ether compounds, such as cyclodextrins, can also be used to coat pharmaceutically active agents. Crown ethers can be used to mask the taste of pharmaceutically active agents by embedding or coacervation methods. Useful cyclodextrins are available under the trade names Commercially available from CTD, Inc.

[0188] In some embodiments, as disclosed, for example, in European Patent No. EP1267829 B1, the above-mentioned polymer coating that affects taste masking may be desirable compared to complexation using ion exchange resins because high drug loading is possible when using polymers compared to complexation using ion exchange resins. Despite claims to the contrary, we have found that the highest useful drug loading on ion exchange resins is about 30% by weight. In contrast, the particle coating of the present invention can be used at a drug loading of 50-95%, which means that the taste-masked particles can contain up to about 95% by weight of active substance and as little as 5% by weight of taste masking polymer. This is a substantially greater drug loading than known ion exchange resins and is very important in situations where the size and weight of the film dosage unit are limited, where maximizing the drug loading into a uniform film is an important consideration.

[0189] In some embodiments, the taste masking agent or controlled release agent can be present in an amount of about 5-80% by weight of the particle. In another embodiment, the taste masking agent is present in an amount of about 5-60% by weight of the particle. In another embodiment, the taste masking agent is present in an amount of about 25-35% by weight of the particle. The exact loading of the drug in the taste-masked coated particle is a function of many parameters, including the drug, the coating, and any flavoring present in the particle or film-forming matrix.

[0190] The taste masking of pharmaceutically active agents with the above-mentioned taste masking agents can be performed by a variety of techniques. The technique coats the pharmaceutically active agent or a portion of the pharmaceutically active agent with a taste masking agent to avoid unpleasant taste effects, such as bitterness, which are usually associated with the pharmaceutically active agent or drug. Useful coating techniques include, but are not limited to, fluidized bed coating, spray congealing coating, agglomeration or granulation coating, embedding coating, co-acceleration coating, injection coating, spin coating, ion exchange coating, and the like.

[0191] Fluidized bed coating methods are commonly used in the pharmaceutical industry to mask the taste of pharmaceutically active agents. Fluidized bed coaters achieve fluidization of pharmaceutically active agents by introducing a continuous process gas stream into a chamber. The coating material is deposited onto the suspension as it passes through the spray path of the coating material. The coated agent is dried. Relatively low water-soluble polymers are commonly used to coat the surface of the active particles. The minimum limit of particle size is about 100 microns to 120 microns. Due to process limitations and product losses, it is difficult to obtain smaller particle sizes. Using this method, water-insoluble pharmaceutically active agents can be suitably coated with water-soluble taste-masking agents.

[0192] In the spray congealing process, both the pharmaceutically active agent and the coating material are sprayed simultaneously into a chamber supplied with a process gas to produce a uniformly coated active substance. The process generally involves coating the active substance with a material that melts at a reasonable temperature, such as a fatty material or a polymer, such as certain Polymer. The material mixture is sprayed through a fine nozzle and cooled by a temperature-controlled air stream or a cold surface. It is important to consider the temperature of the mixture. The melting temperature of the selected coating agent should not exceed the degradation temperature of the pharmaceutically active agent.

[0193] In the agglomeration or granulation process, the pharmaceutically active agent is mixed with a taste masking agent and a solvent by mechanical means or by spray drying. The solvent is gradually removed by vacuum or heating or both. The particles are then agglomerated. Agglomerated particles are usually not fully coated with a taste masking agent and therefore may cause some bitterness. However, the bitterness can be further reduced by incorporating such coated particles into the film of the present invention.

[0194] In a typical encapsulation coating process, one must first select certain compounds that have specific properties that can capture the pharmaceutically active agent into its molecular cage. Compounds such as certain specially made starches and crown ether molecules such as cyclodextrins and zeolites can be used in this process. The compound and agent are encapsulated by ionic attraction. The encapsulated agent is then precipitated out of solution.

[0195] The coacervation coating process uses two oppositely charged polymers in solution. When the solution is neutralized, an insoluble matrix will precipitate out of solution and entrap the pharmaceutically active agent in the insoluble matrix. Examples include the interaction of gum arabic and gelatin solutions and the interaction of cyclodextrin and protein solutions.

[0196] In the injection method, the pharmaceutically active agent and the flavoring or sweetener are dissolved and injected into a polymer matrix to form a dry powder. In the spin coating method, the pharmaceutically active agent is combined with a sugar or fat and spun into coated particles. The details of this method are disclosed in U.S. Patent No. 5,028,632, the contents of which are incorporated herein by reference. In ion exchange coating, the ionic bonding of the pharmaceutically active agent to the ion exchange resin masks the taste of the pharmaceutically active agent.

[0197] Extrusion and spheronization can also be used to taste mask pharmaceutically active microparticles. A certain ratio of one or more active substances and one or more polymers (such as starch, cellulose, gum and / or a combination thereof) are first mixed and thickened by adding a small amount of water. The thickened mixture is then extruded through a single or double nozzle screw. The process forms small spherical particles. The desired particle size is obtained through process control and particle screening.

[0198] Freeze drying (freeze drying) methods can also be used in the practice of the present invention. One or more polymers (such as starch, gum, cellulose and / or their combination) are mixed with a combination of one or more active substances and dissolved (or dispersed) in an aqueous medium. The mixture is then freeze dried on a preformed substrate. The desired particle size can be obtained by process control and product screening.

[0199] In some cases, taste masking may amount to adding together two components, neither of which tastes particularly pleasant, but which, due to their chemical composition, cancel each other out or allow the addition of one or more third substances without a consequent reduction in the pleasantness of the taste.

[0200] The edible water-soluble delivery system of the present invention further comprises one or more members selected from the group consisting of antifoaming agents, plasticizers, surfactants, emulsifiers, thickeners, binders, coolants, saliva stimulants, sweeteners, antimicrobial agents, antigens, and combinations thereof.

[0201] The particle size of the particles used in the present invention is ideally less than about 200 microns, and the taste masking agent is present in an amount of about 15-80% by weight of the particles. A particle size of about 150 microns or less is also available. Ideally, the particle size of the particles is about 100 microns or less. Ideally, the thickness of the film is less than about 380 microns, for example, less than about 250 microns. In addition, the taste masking agent can be present in an amount of about 20-60% by weight of the particles. Ideally, the taste masking agent is present in an amount of about 25-35% by weight of the particles.

[0202] In some embodiments, the particle size of the microparticle bio-effect agent coated with a taste masking or controlled release polymer may be between 50 microns and 250 microns. Ideally, the size of the combination of microparticles and taste masking agent has a particle size of 150 microns or less, such as 100 microns or less. Particle sizes less than 50 microns may be inappropriate in some embodiments because coating such small particles is ineffective due to the large surface area.

[0203] In some embodiments, particle sizes greater than 250 microns may be unsuitable because larger particles may "bridge" during the film formation process, meaning that the particles may extend from the bottom surface of the film to the top surface, or even protrude beyond the surface of the film. Such bridging may result in streaking and non-uniformity of the finished film. Any protruding particles may also be subject to environmental stress and premature decomposition, resulting in non-uniformity of dosing.

[0204] The particles may be spherical, substantially spherical or non-spherical, such as irregularly shaped particles or ellipsoidal particles. Elliptical particles or ellipsoids are particularly desirable because they tend to settle to a lesser extent than spherical particles, thereby maintaining uniformity in the film-forming matrix.

[0205] When an active agent is present in the film, the amount of active substance per unit area is determined by the uniform distribution of the film. For example, when the film is cut into individual dosage forms, the amount of active substance in the dosage form can be known very accurately. This is because the amount of active substance in a given area is substantially the same as the amount of active substance in an area of ​​the same size in another part of the film. Dosage accuracy is particularly advantageous when the active substance is a drug, i.e., a pharmaceutical product.

[0206] Uniformity is determined by a drug variation of no more than 10% by weight throughout the matrix. Ideally, the drug variation is less than 5%, less than 2%, less than 1%, or less than 0.5%. In addition, the particle size of the microparticles is 200 microns or less. In addition, the thickness of the film matrix is ​​ideally less than about 380 microns.

[0207] additive

[0208] The various additives that can be incorporated into the compositions of the present invention can provide a variety of different functions. Examples of additive categories include excipients, lubricants, buffers, stabilizers, foaming agents, pigments, colorants, fillers, loosening agents, sweeteners, flavorings, flavorings, release modifiers, adjuvants, plasticizers, flow promoters, mold release agents, polyols, granulating agents, diluents, adhesives, buffers, absorbents, glidants, binders, anti-adherents, acidulants, softeners, resins, moderators, solvents, surfactants, emulsifiers, elastomers, and mixtures thereof. These additives can be added before or with the active ingredient.

[0209] condiment

[0210] Flavorings can be selected from natural and synthetic flavoring liquids. An illustrative list of such agents includes volatile oils, synthetic flavoring oils, flavoring aromatics, oils, liquids, oleoresins, or extracts obtained from plants, leaves, flowers, fruits, stems, and combinations thereof. A non-limiting representative list of examples includes peppermint essential oil, cocoa essential oil, and citrus essential oils, such as lemon, orange, grape, lime, and grapefruit essential oils, and fruit flavors, including apple, pear, peach, grape, strawberry, raspberry, cherry, plum, pineapple, apricot, or other fruit flavorings.

[0211] Useful condiments or flavorings include natural condiments and artificial condiments. These condiments can be selected from synthetic flavoring oils and flavoring aromatics, and / or oils, oleoresins, and extracts obtained from plants, leaves, flowers, fruits, etc., and their combinations. Non-limiting flavoring oils include: spearmint essential oil, cinnamon essential oil, peppermint essential oil, clove essential oil, laurel essential oil, thyme essential oil, cedar leaf essential oil, nutmeg essential oil, sage essential oil, and bitter almond essential oil. Artificial, natural or synthetic fruit condiments are also useful, such as vanilla, chocolate, coffee, cocoa and citrus oils, including lemon, orange, grape, lime and grapefruit essential oils, and fruit essences, including apples, pears, peaches, strawberries, raspberries, cherries, plums, pineapples, apricots, etc. These condiments can be used alone or in combination. Commonly used condiments include mint (such as peppermint), artificial vanilla extract, cinnamon derivatives and various fruit condiments, whether alone or in combination. Flavorings such as aldehydes and esters may also be used, including cinnamyl acetate, cinnamaldehyde, citral, diethyl acetal, dihydrocarvyl acetate, eugenyl formate, p-methylanisole, etc. Other examples of aldehyde flavorings include, but are not limited to, acetaldehyde (apple); benzaldehyde (cherry, almond); cinnamaldehyde (cinnamon); citral, i.e., α-citral (lemon, lime); neral, i.e., β-citral (lemon, lime); decanal (orange, lemon); ethyl vanillin (vanilla extract, cream); heliotropin, i.e., piperonal (vanilla extract, cream); vanillin (vanilla extract, cream); α-amyl cinnamaldehyde (spicy fruity); butyraldehyde (butter, cheese); valeraldehyde (butter, cheese); citronellal (modified agents, many types); decanal (citrus fruits); aldehyde C-8 (citrus fruits); aldehyde C-9 (citrus fruits); aldehyde C-12 (citrus fruits); 2-ethylbutyraldehyde (berries); hexenal, i.e., trans-2 (berries); toluylaldehyde (cherries, almonds); veratraldehyde (vanilla); 12,6-dimethyl-5-heptenal, i.e., melonal (melon); 2-dimethyloctanal (green fruits); and 2-dodecenal (citrus, mandarin oranges); cherries; grapes; mixtures thereof; etc.

[0212] Other useful flavorings include aldehydes and esters such as benzaldehyde (cherry, almond); citral, i.e., α-citral (lemon, lime); neral, i.e., β-citral (lemon, lime); decanal (orange, lemon); aldehyde C-8 (citrus fruits); aldehyde C-9 (citrus fruits); aldehyde C-12 (citrus fruits); toluylaldehyde (cherry, almond); 2,6-dimethyloctanol (green fruits); and 2-dodecenal (citrus, mandarin orange); combinations thereof, and the like.

[0213] The amount of condiment used is generally the amount of preference, depending on factors such as condiment type, separate condiments, and desired strength. In order to obtain the desired result in the final product, the amount can be varied. Such changes are within the capabilities of those skilled in the art without excessive experimentation. Typically, amounts of about 0.1 % by weight to about 30 % by weight can be used to practice the present invention.

[0214] Sweeteners

[0215] Suitable sweeteners include both natural sweeteners and artificial sweeteners. Non-limiting examples of suitable sweeteners include, for example: water-soluble sweeteners, such as monosaccharides, disaccharides and polysaccharides, for example xylose, ribose, glucose (dextrose), mannose, galactose, fructose (levulose), sucrose (sugar), high fructose corn syrup, maltose, invert sugar (a mixture of fructose and glucose derived from sucrose), partially hydrolyzed starch, corn syrup solids and dihydrochalcone; water-soluble artificial sweeteners, such as soluble saccharin salts, i.e., saccharin sodium or calcium salts, sodium, ammonium or calcium salts of 3,4-dihydro-6-methyl-1,2,3-oxathiazine-4-one-2,2-dioxide, potassium salts of 3,4-dihydro-6-methyl-1,2,3-oxathiazine-4-one-2,2-dioxide (acesulfame-K), saccharin free acid form, etc.; dipeptide-based sweeteners, such as L-aspartic acid-derived sweeteners, for example, L-aspartyl-L-phenylalanine methyl ester (aspartame), L-α-aspartyl-N-(2,2,4,4-tetramethyl-3-thietanyl)-D-alaninamide hydrate, L-aspartyl-L-phenylglycerol and L-aspartyl-L-2,5-dihydrophenylglycine, L-aspartyl-2,5-dihydro-L-phenylalanine, L-aspartyl-L-(1-cyclohexene)-alanine, etc.; water-soluble sweeteners derived from naturally occurring water-soluble sweeteners, such as chlorinated derivatives of common sugar (sucrose), known as, for example, sucralose; and protein-based sweeteners, such as thaurnatoccous danielli (thaumatin I and II). Naturally occurring high intensity sweeteners such as monk fruit, stevia, stevioside, monetarcin, and glycyrrhizin may also be used.

[0216] Typically, an effective amount of an auxiliary sweetener is used to provide the desired sweetness level for a particular composition, and this amount will vary with the selected sweetener. This amount will typically be 0.01% by weight to about 10% by weight of the composition. These amounts can be used to achieve the desired sweetness level, regardless of the flavor level obtained from any optional flavoring oil used. Of course, there is no need to add a sweetener to a film intended for non-oral administration.

[0217] Colorants

[0218] Color additives useful in the present invention include food, drug and cosmetic colors (FD&C), drug and cosmetic colors (D&C) or external drug and cosmetic colors (Ext. D&C). These pigments are dyes, their corresponding lakes, and certain natural and derived colorants. Lakes are dyes absorbed onto aluminum hydroxide.

[0219] Other examples of colorants include known azo dyes, organic or inorganic pigments, or colorants of natural origin. Inorganic pigments are preferred, such as oxides or iron or titanium, the addition concentration of these oxides based on the weight of all components in the range of about 0.001% to about 10%, preferably about 0.5% to about 3%.

[0220] The description of the embodiments of the present invention described herein is intended to provide a general understanding of the structures of the various embodiments, and the description is not intended to serve as a complete description of all elements and features of the devices and systems that may utilize the structures described herein. According to the teachings of this article, many other embodiments will become apparent to those skilled in the art. Other embodiments can be utilized and derived therefrom, so that structural and logical substitutions and changes can be made without departing from the scope of the present disclosure. The accompanying drawings are also representative only and are not necessarily drawn to scale. In order to make the embodiments of the present invention easy to explain, some proportions may be enlarged and other proportions reduced. Therefore, this specification and the accompanying drawings will be regarded as illustrative, not restrictive.

[0221] Such embodiments of the subject matter of the present invention are referred to herein individually and / or collectively by the term "embodiment", which is merely for convenience and is not intended to actively limit the scope of the present application to any single embodiment or inventive concept (if more than one invention is actually shown). Therefore, although specific embodiments have been illustrated and described herein, it should be understood that any arrangement intended to achieve the same purpose replaces the specific embodiments shown. The present invention is intended to cover any and all changes or variations of the various embodiments. Combinations of the above embodiments and other embodiments not specifically described herein will be apparent to those skilled in the art by reviewing the above description.

[0222] In the above detailed description, it can be seen that various features are grouped together in various embodiments for the purpose of streamlining the disclosure. This method of disclosure should not be interpreted as reflecting an intention that the claimed embodiments have more features than those explicitly recited in each claim. Rather, as the following claims reflect, the inventive subject matter relies on less than all the features of a single embodiment. Therefore, the appended claims are hereby incorporated into the detailed description, with each claim standing by itself as a separate embodiment.

[0223] experiment

[0224] Embodiment 1:

[0225] Figure 3 It is a block diagram of an embodiment of a machine in the form of a computing system 100, wherein it is a group of instructions 102, which when executed, causes the machine to perform any one or more methods in the method according to an embodiment of the present invention. In some embodiments, the machine is operated as a stand-alone device. In some embodiments, the machine is connected to other machines (e.g., via network 122). In a networked implementation, the machine is operated with the ability of a server or client user machine in a server-client user network environment. Exemplary embodiments of the machine considered by the present invention include but are not limited to server computers, client user computers, personal computers (PCs), tablet computers, personal digital assistants (PDAs), cellular phones, mobile devices, palmtop computers, laptop computers, desktop computers, communication devices, personal trusted devices, web devices, network routers, switches or bridges, or any machine capable of executing a group of instructions (sequential instructions or other instructions), which specify the actions to be performed by the machine.

[0226] Computing system 100 includes a processing device 104 (e.g., a central processing unit (CPU), a graphics processing unit (GPU), or both), a program storage device 106, and a data storage device 108, which communicate with each other via a bus 110. Computing system 100 also includes a display device 112 (e.g., a liquid crystal display (LCD), a flat panel, a solid-state display, or a cathode ray tube (CRT)). The computing system 100 includes an input device 116 (e.g., a keyboard); a cursor control device 126 (e.g., a mouse); a disk drive unit 114; a signal generating device 118 (e.g., a speaker and a remote control; and a network interface device 124, which are operably coupled together and / or operably coupled to other functional blocks via a bus 110. The disk drive unit 114 includes a machine-readable medium 120 on which is stored one or more sets of instructions 102 (e.g., software) embodying any one or more of the methods or functions herein (including those described herein). The instructions 102 are also stored by the computing system 100 during execution, completely or at least partially residing on the program storage device 106, The program storage device 106 and the processing device 104 also constitute machine-readable media. Special hardware implementations such as, but not limited to, application-specific integrated circuits, programmable logic arrays, and other hardware devices can also be constructed to implement the methods described herein. Applications of the apparatus and systems including various embodiments widely include various electronic and computer systems. Some embodiments implement functions in two or more specific interconnected hardware modules or devices using related controls and data signals, which communicate between and through the modules, or as part of an application-specific integrated circuit. Therefore, the exemplary system is applicable to software, firmware, and hardware implementations.

[0227] According to various embodiments, the methods, functions or logic described herein are implemented as one or more software programs running on a computer processor. Special hardware implementations including but not limited to application specific integrated circuits, programmable logic arrays and other hardware devices can also be constructed to implement the methods described herein. In addition, alternative software implementations can also be constructed, including but not limited to distributed processing or component / object distributed processing, parallel processing or virtual machine processing to implement the methods, functions or logic described herein.

[0228] The embodiment contemplates a machine-readable medium or computer-readable medium containing instructions 102, or receiving and executing instructions 102 from propagated signals, so that a device connected to a network environment 122 can send or receive voice, video, or data, and communicate over the network 122 using the instructions 102. The instructions 102 are further sent or received over the network 122 via a network interface device 124. The machine-readable medium also contains a data structure for storing data, which can be used in illustrative embodiments of the systems and methods herein to provide a functional relationship between the data and the machine or computer.

[0229] Although the machine-readable medium 120 is shown as a single medium in the example embodiment, the term "machine-readable medium" should be considered to include a single medium or multiple media (e.g., a centralized or distributed database, and / or associated caches and servers) that store one or more sets of instructions. The term "machine-readable medium" should also be considered to include any medium that can store, encode, or carry a set of instructions for execution by a machine and cause the machine to perform any one or more of the methods of the embodiment. Therefore, the term "machine-readable medium" should be considered to include, but is not limited to: solid-state memory, such as a memory card or other packaging that holds one or more read-only (non-volatile) memories, random access memories, or other rewritable (volatile) memories; magneto-optical or optical media, such as disks or tapes; and / or digital file attachments to e-mail or other self-contained information archives or archive sets are considered to be equivalent to tangible storage media. Therefore, the embodiment is considered to include any one or more of the tangible machine-readable media or tangible distribution media listed herein, and includes equivalents and successor media recognized in the art that store the software implementation of this article.

[0230] It should also be noted that the software implementing the methods, functions, or logic herein is optionally stored on a tangible storage medium, such as: magnetic media, such as disks or tapes; and magneto-optical or optical media, such as disks; or solid-state media, such as a memory card or other packaging containing one or more read-only (non-volatile) memories, random access memories, or other rewritable (volatile) memories. Digital file attachments to e-mails or other independent information archives or archives are considered distribution media equivalent to tangible storage media. Therefore, the present disclosure is considered to include the tangible storage media or distribution media listed herein and other equivalent and successor media, in which the software implementation of the present invention is stored.

[0231] As previously mentioned, although the specification describes components and functions implemented according to embodiments of the present invention with reference to specific standards and protocols, the embodiments are not limited to such standards and protocols.

[0232] The Abstract is provided to comply with the requirements of 37 CFR § 1.72(b), which requires an abstract that allows the reader to quickly ascertain the nature of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. In addition, in the above Detailed Description, it can be seen that various features are grouped together in a single embodiment for the purpose of streamlining the disclosure. This method of disclosure should not be interpreted as reflecting the intention that the claimed embodiments require more features than those expressly recited in each claim. Rather, as reflected in the following claims, the inventive subject matter relies on less than all the features of a single embodiment. Therefore, the following claims are hereby incorporated into the Detailed Description, wherein each claim itself may serve as a separately claimed subject matter.

[0233] Although specific exemplary embodiments have been described, it will be apparent that various modifications and changes may be made to these embodiments without departing from the broader scope of the inventive subject matter described herein. Therefore, this specification and the accompanying drawings will be considered illustrative, rather than restrictive. The accompanying drawings forming a part of this article show specific embodiments of the practical subject matter by way of illustration and not limitation. The illustrated embodiments are described in sufficient detail to enable those skilled in the art to practice the teachings of this article. Other embodiments may be utilized and derived therefrom so that structural and logical substitutions and changes may be made without departing from the scope of this disclosure. Therefore, this specific embodiment should not be adopted in a restrictive sense, and the scope of the various embodiments is limited only by the appended claims together with the full scope of equivalents authorized by such claims.

[0234] Given the teachings of the invention provided herein, one of ordinary skill in the art will be able to consider other implementations and applications of the technology of the present invention. Although illustrative embodiments of the present invention have been described herein with reference to the accompanying drawings, it should be understood that the invention is not limited to those precise embodiments, and that various other changes and modifications may be made in the embodiments by one of ordinary skill in the art without departing from the scope of the appended claims.

Claims

1. A system for creating one or more personalized individual unit doses (IUDs) associated with a treatment for an individual, the system comprising: a polymeric carrier matrix selected from the group consisting of polyethylene oxide, polyvinyl pyrrolidone, polyvinyl alcohol, hydrophilic cellulosic polymers, polysaccharides, gums, and combinations thereof; Active substances; a device configured to combine the polymer carrier matrix and the active substance into a film using a mixing and film-forming process that provides uniformity of the contents of the one or more personalized IUDs made from the film, the device being a film-forming assembly or a sheet-forming assembly selected from the group consisting of a wet casting assembly, an extruder assembly, and a spray drying assembly; A networked control system configured to electronically transmit health information measured from the individual; wherein the networked control system is configured to: a) electronically transmitting the health information to a medical professional for use in preparing a medical prescription defining a prescribed amount of active substance to be included in the one or more personalized IUDs; b) electronically transmitting the medical prescription from the medical professional to the IUD manufacturer; and c) electronically instructing the IUD manufacturer to fabricate the film from the polymer carrier matrix and the active substance according to the prescribed amount of the active substance in the medical prescription associated with the treatment of the individual; as well as Additional means for dividing or cutting the film into a plurality of the one or more personalized IUDs, wherein each of the one or more personalized IUDs contains an amount of the active substance that varies by no more than 10% relative to a prescribed amount of the active substance.

2. The system of claim 1, wherein the networked control system comprises a processor, a memory storage, and executable instructions; and further comprises at least one of a display device, an alphanumeric input device, a cursor control device, a drive unit, a machine-readable medium, and a signal generating device.

3. The system of claim 1, comprising a biometric measurement module, the biometric measurement module being interfaced with the individual.

4. The system of claim 3, wherein the biometric measurement module comprises at least one measurement device selected from the group consisting of: an invasive measurement device, a non-invasive measurement device, and a combination thereof.

5. The system of claim 3, wherein the biometric measurement module comprises a device selected from the group consisting of: an acoustic instrument, a visual instrument, a tactile instrument, a chemical instrument, a biological instrument, an electrical instrument, a thermal instrument, and combinations thereof.

6. The system of claim 3, wherein the biometric measurement module comprises a device selected from the group consisting of: a camera, a video oscilloscope, a lighting system, a colorimeter, a spirometer, a Holter monitor, an ultrasound probe, a blood chemistry instrument, a blood flow measurement device, a blood content measurement device, a thermal measurement device, and combinations thereof.

7. A system as described in claim 3, wherein the biometric measurement module includes a device selected from the group consisting of: an electroencephalogram (EEG) machine; an electrocardiogram (EKG) machine; an electromyogram (EMG) machine; an echocardiogram (ECG) machine; an atrial fibrillation device; a stethoscope; a pharyngoscope; a sinusoscope; an otoscope; a laparoscope; a dermatoscope; a blood gas measurement device; a multi-purpose camera; a retinal camera; an eye measurement device; an intraoral camera; an abdominal ultrasound device; a vascular ultrasound device; a transvaginal ultrasound device; a skin surface measurement device that measures one or more of temperature, blood flow, blood sugar, skin color, texture, blood lipid content, blood cholesterol content; an accelerometer; a motion sensor, and a combination thereof.

8. The system of claim 3, wherein the biometric measurement module is at least one device comprising one or more software applications for obtaining biometric information, information for making a diagnosis, information for a medical assessment, information for assessing the effectiveness of treatment and / or changes in treatment required for the individual, or a combination thereof.

9. The system of claim 8, wherein the at least one device is selected from the group consisting of an implant, a computer, a phone, a mobile phone, a tablet, a laptop, a watch, a wearable device, and combinations thereof.

10. The system of claim 1, wherein the medical prescription further comprises a pharmaceutical formulation of the polymer carrier matrix.

11. The system of claim 1, wherein the hydrophilic cellulosic polymer is a polymer carrier selected from the group consisting of hydroxypropylmethylcellulose (HPMC), hydroxyethylcellulose (HPC), hydroxypropylcellulose, carboxymethylcellulose, and combinations thereof.

12. The system of claim 10, wherein the polymer carrier matrix is ​​selected from the group consisting of polysaccharides, gums, and combinations thereof.

13. The system of claim 12, wherein the drug formulation comprises a solvent selected from the group consisting of water, alcohol, acetone, methylene chloride, and combinations thereof.

14. The system of claim 10, wherein the drug formulation comprises a component selected from the group consisting of adjuvants, penetration enhancers, plasticizers, thickeners, rheology modifiers, alcohols, bulking agents, colorants, flavoring agents, and combinations thereof.

15. The system of claim 1, wherein the active substance is selected from the group consisting of pharmaceutically active substances, small molecules, macromolecules, biologics, microorganisms, allergens, enzymes, and combinations thereof.

16. The system of claim 1, wherein the active substance is a drug or biologically active substance selected from the group consisting of angiotensin converting enzyme inhibitors, antianginal drugs, antiarrhythmic drugs, antiasthmatic agents, antihypercholesterolemic drugs, analgesics, anesthetics, anticonvulsants, antidepressants, antidiabetic agents, antidiarrheal preparations, antidotes, antihistamines, antihypertensives, anti-inflammatory agents, antilipid agents, antiemetics, antistroke agents, antithyroid preparations, antineoplastics, antiviral agents, Acne drugs, alkaloids, amino acid preparations, antitussives, antihyperuricemia drugs, anabolic preparations, systemic and non-systemic anti-infectives, anti-neoplastic agents, anti-Parkinson's disease agents, anti-rheumatic agents, appetite stimulants, biological response modifiers, blood regulators, bone metabolism regulators, cardiovascular agents, central nervous system stimulants, cholinesterase inhibitors, contraceptives, decongestants, dietary supplements, dopamine receptor agonists, endometriosis control agents, erectile dysfunction therapeutic agents, fertility agents, gastrointestinal tract agents, hormones, hypercalcemia and hypocalcemia control agents, immunomodulators, immunosuppressants, motion sickness therapeutic agents, muscle relaxants, osteoporosis preparations, oxytocin, parasympathetic agents, parasympathomimetic agents, prostaglandins, respiratory agents, sedatives, smoking cessation aids, sympathetic nerve blockers, tremor preparations, urinary tract agents, vasodilators, laxatives, antacids, ion exchange resins, antipyretics, appetite suppressants, expectorants, antiulcer agents, anti-inflammatory substances, coronary vasodilators, brain dilators The invention relates to agents that can be used to treat arthritis, urinary tract infections, arteriosclerosis, angiotensin-converting agents, angiotensin-converting agents, vasopressors, angiotensin-converting agents, vasopressors, angiotensin-converting agents, sedatives, antipsychotics, antineoplastics, anticoagulants, antithrombotics, hypnotics, antiemetics, antinausea agents, anticonvulsants, neuromuscular drugs, hyperglycemic and hypoglycemic agents, thyroid and antithyroid preparations, diuretics, antispasmodics, uterine relaxants, antiobesity drugs, erythropoiesis-stimulating drugs, antiasthmatics, cough suppressants, mucolytics, DNA and genetically modified drugs, and combinations thereof.

17. The system of claim 1, further comprising a database or a network system for storing the health information in the database or the network system.

18. A method of producing one or more personalized individual unit doses (IUDs) containing an active substance for an individual, the method comprising: a) obtaining biometric measurements related to the health of the individual; b) transmitting said biometric measurement result to the IUD manufacturer of the medical or prescription product; c) using the system of claim 1 to manufacture the one or more personalized IUDs according to a medical prescription specific to the individual; as well as d) delivering the one or more personalized IUDs made according to the medical prescription to the individual.

19. The method of claim 18, further comprising the step of electronically transmitting the biometric measurement of the individual to a medical professional authorized to write the medical prescription prior to the step of transmitting the biometric measurement to the IUD manufacturer.

20. The method of claim 19, further comprising the step of electronically transmitting the medical prescription to the IUD manufacturer prior to the step of manufacturing the one or more personalized IUDs.

21. The method of claim 20, further comprising the step of electronically verifying insurance membership and determining coverage for the individual prior to the step of transmitting the medical prescription to the IUD manufacturer.

22. The method of claim 18, wherein the film dosage form is multi-layered, has a second film layer, and the active agent is incorporated into the second film layer.

23. The method of claim 18, wherein the active substance is coated onto the one or more personalized IUDs.

24. The method of claim 18, wherein the active substance is sprayed onto the one or more personalized IUDs.

25. The method of claim 18, wherein the active material is deposited onto the one or more personalized IUDs.

26. The method of claim 18, wherein the active substance is printed onto the one or more personalized IUDs.

27. The method of claim 18, further comprising the step of packaging the manufactured one or more personalized IUDs before delivering the one or more personalized IUDs and marking the amount of active substance in each of the one or more personalized IUDs on the packaging.

28. The method of claim 18, wherein each of the one or more personalized IUDs contains an amount of active substance that is within 10% of the amount printed on the package label.

29. The method of claim 18, wherein the active substance is selected from the group consisting of pharmaceutically active substances, small molecules, macromolecules, biologics, microorganisms, allergens, enzymes, and combinations thereof.

30. The method of claim 18, wherein the active substance is a drug or biologically active substance selected from the group consisting of angiotensin converting enzyme inhibitors, antianginal drugs, antiarrhythmic drugs, antiasthmatic agents, antihypercholesterolemic drugs, analgesics, anesthetics, anticonvulsants, antidepressants, antidiabetic agents, antidiarrheal preparations, antidotes, antihistamines, antihypertensives, anti-inflammatory agents, antilipid agents, antiemetics, antistroke agents, antithyroid preparations, antitumor drugs, antiviral agents, Acne drugs, alkaloids, amino acid preparations, antitussives, antihyperuricemia drugs, anabolic preparations, systemic and non-systemic anti-infectives, anti-neoplastic agents, anti-Parkinson's disease agents, anti-rheumatic agents, appetite stimulants, biological response modifiers, blood regulators, bone metabolism regulators, cardiovascular agents, central nervous system stimulants, cholinesterase inhibitors, contraceptives, decongestants, dietary supplements, dopamine receptor agonists, endometriosis control agents, erectile dysfunction therapeutic agents, fertility agents, gastrointestinal tract agents, hormones, hypercalcemia and hypocalcemia control agents, immunomodulators, immunosuppressants, motion sickness therapeutic agents, muscle relaxants, osteoporosis preparations, oxytocin, parasympathetic agents, parasympathomimetic agents, prostaglandins, respiratory agents, sedatives, smoking cessation aids, sympathetic nerve blockers, tremor preparations, urinary tract agents, vasodilators, laxatives, antacids, ion exchange resins, antipyretics, appetite suppressants, expectorants, antiulcer agents, anti-inflammatory substances, coronary vasodilators, brain dilators The invention relates to agents that can be used to treat arthritis, urinary tract infections, arteriosclerosis, angiotensin-converting agents, angiotensin-converting agents, vasopressors, angiotensin-converting agents, vasopressors, angiotensin-converting agents, sedatives, antipsychotics, antineoplastics, anticoagulants, antithrombotics, hypnotics, antiemetics, antinausea agents, anticonvulsants, neuromuscular drugs, hyperglycemic and hypoglycemic agents, thyroid and antithyroid preparations, diuretics, antispasmodics, uterine relaxants, antiobesity drugs, erythropoiesis-stimulating drugs, antiasthmatics, cough suppressants, mucolytics, DNA and genetically modified drugs, and combinations thereof.

31. The method of claim 18, wherein the delivery is by private courier, FedEx, drone, UPS, or national postal service.

32. The method of claim 18, wherein the polymer carrier matrix is ​​provided in a plurality of units, wherein each unit contains an amount of the polymer carrier matrix according to the medical prescription.

33. The method of claim 18, wherein the step of manufacturing the one or more personalized IUDs is performed under the supervision of a pharmaceutical compounder.

34. The method of claim 18, further comprising the steps of: A plurality of manufactured one or more personalized IUDs are co-packaged for delivery to the individual, each of the manufactured one or more personalized IUDs being based on one or more prescriptions specific to the individual.

35. The method of claim 34, wherein color coding is performed in the packaging of each of the plurality of the manufactured one or more personalized IUDs to provide medication instructions to the individual.

36. The method of claim 34, wherein a scannable code is printed on the packaging of each of the plurality of the manufactured one or more personalized IUDs or on the actual one or more personalized IUDs, such that the individual's mobile device can scan the code to retrieve medication information and instructions for use.

37. The method of claim 36, wherein the scannable code is a QR code.

38. The method of claim 19, wherein sending the information to the medical professional comprises using a telecommunications device.

39. The method of claim 18, wherein the medical prescription comprises more than one active substance to be administered to the individual with the one or more personalized IUDs.

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