A photoacoustic dynamic therapy instrument

Abstract

The present invention belongs to the technical field of medical devices, and particularly relates to a photoacoustic dynamic therapy instrument. A photoacoustic dynamic therapy instrument includes a chassis, and is characterized in that: it further includes an acousto-optic generating device and a control component; the acousto-optic generating device and the control component are both arranged in the chassis; the acousto-optic generating device is electrically connected to the control component; the acousto-optic generating device can emit laser or ultrasonic waves alone, or can emit laser and ultrasonic waves simultaneously. This application combines the photodynamic technology and the sonodynamic technology to provide a portable device capable of non-invasive acousto-optic synchronous treatment for superficial and deep tissue diseases. Compared with the prior art, it has technical effects such as convenient and simple operation, less amount of sensitizer used, and guaranteed treatment effect.

Description

Technical Field

[0001] This application belongs to the technical field of medical equipment, and particularly relates to a photoacoustic dynamic therapy instrument. Background Art

[0002] At present, the lasers used for photodynamic therapy (PDT) can only provide light of one or several wavelengths. Moreover, due to the limited penetration of laser, the functions of the lasers are limited and can only be used for treating superficial lesions. While the sono-dynamic therapy (SDT) instrument uses ultrasonic waves to activate sensitizers, which can penetrate deep tissues and make up for the deficiencies of PDT.

[0003] Application Content

[0004] In view of this, this application provides a photoacoustic dynamic therapy instrument to solve the technical problems existing in the prior art.

[0005] The solution adopted by this application to solve its technical problems is as follows:

[0006] A photoacoustic dynamic therapy instrument includes a chassis, and is characterized in that: it further includes an acousto-optic generating device and a control component; both the acousto-optic generating device and the control component are arranged in the chassis; the acousto-optic generating device is electrically connected to the control component; the acousto-optic generating device can emit laser or ultrasonic waves alone, or can emit laser and ultrasonic waves simultaneously.

[0007] Preferably, the acousto-optic generating device includes a laser generator, an acousto-optic modulator, an ultrasonic oscillation circuit and an ultrasonic transducer; the laser generator and the ultrasonic oscillation circuit are electrically connected to the control component, the laser generator is used to emit laser, the acousto-optic modulator is used to adjust the laser emitted by the laser generator, the ultrasonic oscillation circuit is used to generate ultrasonic oscillation, and the ultrasonic transducer is used to convert the ultrasonic oscillation generated by the ultrasonic oscillation circuit into ultrasonic waves.

[0008] Preferably, the acousto-optic generating device includes a laser generator, an acousto-optic transmission tunnel and an acousto-optic synchronization component; the laser generator is used to emit laser, the acousto-optic synchronization component is used to form a ring array laser source and generate ultrasonic waves through the cooperation of the acousto-optic transmission tunnel, and the acousto-optic transmission tunnel is used to transmit the laser and ultrasonic waves generated by the acousto-optic synchronization component.

[0009] Preferably, the cross-section of the acousto-optic transmission tunnel has a circular structure; the acousto-optic synchronization component includes a cylindrical part and a conical part, and an annular grating array that penetrates each other is arranged inside the cylindrical part and the conical part; the acousto-optic synchronization component is arranged in the acousto-optic transmission tunnel and coincides with the axis of the acousto-optic transmission tunnel, and the conical part of the acousto-optic synchronization component faces the incident end of the laser.

[0010] Preferably, the laser generator is a laser diode.

[0011] Preferably, the acousto-optic generating device further includes a laser beam expander disposed between the laser generator and the acousto-optic synchronization component for adjusting the radiation pattern of the laser beam.

[0012] Preferably, the acousto-optic generating device further includes an acousto-optic modulator for adjusting the intensity and frequency of the concentric ring-shaped laser source formed by the annular grating array.

[0013] Preferably, the acousto-optic generating device can emit one or several of ultraviolet light of 193 - 337 nm, blue light of 488 nm, green light of 514 nm, red light of 633 nm, near-infrared light of 1064 nm, and adjustable light of 570 - 650 nm.

[0014] Preferably, the ultrasonic frequency generated by the acousto-optic generating device is from 100 kHz to 2 MHz.

[0015] Preferably, the photoacoustic dynamic therapy instrument further includes a laser intensity adjustment component, a laser frequency adjustment component, an ultrasonic intensity adjustment component, and an ultrasonic frequency adjustment component; the laser intensity adjustment component, the laser frequency adjustment component, the ultrasonic intensity adjustment component, and the ultrasonic frequency adjustment component are all disposed inside and / or on the chassis; the laser intensity adjustment component, the laser frequency adjustment component, the ultrasonic intensity adjustment component, and the ultrasonic frequency adjustment component are all electrically connected to the control component.

[0016] Preferably, the photoacoustic dynamic therapy instrument further includes a laser display and an ultrasonic display; the laser display and the ultrasonic display are both disposed inside and / or on the chassis; the laser display and the ultrasonic display are both electrically connected to the control component.

[0017] Preferably, the photoacoustic dynamic therapy instrument further includes a laser waveguide device and an ultrasonic waveguide device; the laser waveguide device and the ultrasonic waveguide device are both disposed inside and / or on the chassis; the laser waveguide device and the ultrasonic waveguide device are both electrically connected to the acousto-optic generating device.

[0018] Preferably, the photoacoustic dynamic therapy instrument further includes a photoacoustic waveguide device for transmitting laser and / or ultrasonic waves.

[0019] Beneficial technical effects:

[0020] 1. By combining the photoacoustic dynamic technology, the present application provides a portable device that can be used for non-invasive treatment of superficial and deep tissue diseases simultaneously. Compared with the prior art, it has technical effects such as convenient and simple operation, less amount of sensitizer, and guaranteed treatment effect.

[0021] 2. In the embodiment of the present application where a laser generator, an acousto-optic transmission tunnel, and an acousto-optic synchronization component are used as the acousto-optic generating device, it can not only be used for non-invasive acousto-optic synchronous treatment of superficial and deep tissue diseases simultaneously, but also has technical effects such as uniform energy distribution, good acousto-optic signal synchronization performance, simple operation, and convenient use. At the same time, using a ring laser source as the laser source for acousto-optic synchronous treatment also has technical effects such as high energy efficiency, small side effects on the human body, and higher safety performance.

[0022] The technical solutions and technical effects of the present application will be introduced in detail below in conjunction with the specification drawings and specific embodiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 : Structural schematic diagram of the first preferred embodiment;

[0024] Figure 2 : Structural schematic diagram of the second preferred embodiment;

[0025] Figure 3 : Structural schematic diagram of the acousto-optic generating device;

[0026] Figure 4 : Front projection view of the acousto-optic synchronization component;

[0027] Figure 5 : Side perspective view of the acousto-optic synchronization component;

[0028] IDENTIFICATION DESCRIPTION:

[0029] 10 - Acousto-optic generating device, 20 - Laser intensity adjustment component, 30 - Laser frequency adjustment component, 40 - Ultrasonic intensity adjustment component, 50 - Ultrasonic frequency adjustment component, 60 - Laser display, 70 - Ultrasonic display, 80 - Laser waveguide device, 90 - Ultrasonic waveguide device, 100 - Photoacoustic waveguide device;

[0030] 110 - Laser generator, 120 - Acousto-optic transmission tunnel, 130 - Acousto-optic synchronization component;

[0031] 1310 - Cylindrical part, 1320 - Conical part, 1330 - Ring grating array. SPECIFIC EMBODIMENTS

[0032] The First Preferred Embodiment

[0033] Please refer to Figure 1, a photoacoustic dynamic therapy instrument, comprising a chassis, in which an acousto-optic generating device 10, a laser intensity adjusting component 20, a laser frequency adjusting component 30, an ultrasonic intensity adjusting component 40, an ultrasonic frequency adjusting component 50, a laser display 60, an ultrasonic display 70, a laser waveguide device 80, an ultrasonic waveguide device 90 and a control component are arranged; the laser intensity adjusting component 20, the laser frequency adjusting component 30, the ultrasonic intensity adjusting component 40, the ultrasonic frequency adjusting component 50, the laser display 60 and the ultrasonic display 70 are all arranged inside and / or on the chassis and are electrically connected to the control component; the laser waveguide device 80 and the ultrasonic waveguide device 90 are both connected to the acousto-optic generating device 10 and are used for receiving and transmitting the laser and / or ultrasonic waves emitted by the acousto-optic generating device 10.

[0034] The acousto-optic generating device 10 includes a laser generator, an acousto-optic modulator, an ultrasonic oscillation circuit and an ultrasonic transducer; the laser generator and the ultrasonic oscillation circuit are electrically connected to the control component. The laser generator is used for emitting laser, the acousto-optic modulator is used for adjusting the laser emitted by the laser generator, the ultrasonic oscillation circuit is used for generating ultrasonic oscillation, and the ultrasonic transducer is used for converting the ultrasonic oscillation generated by the ultrasonic oscillation circuit into ultrasonic waves.

[0035] The laser waveguide device 80 and the ultrasonic waveguide device 90 are respectively used for receiving and transmitting the laser emitted by the laser generator and the ultrasonic waves generated by the ultrasonic transducer. Various waveguide devices or components in the prior art can be used as the laser waveguide device and the ultrasonic waveguide device of the present application, and a flexible waveguide device or component is preferably used.

[0036] The laser generator can be various laser emission components or parts in the prior art such as a laser or a laser diode, etc. The acousto-optic modulator, the ultrasonic oscillation circuit and the ultrasonic transducer can be any component or part in the prior art with the same or similar functions. The control component can be a control circuit board, a control chip or a microcomputer such as an industrial control computer, etc.

[0037] The acousto-optic generating device 10 is electrically connected to the control component. The acousto-optic generating device 10 can emit laser or ultrasonic waves alone, or can emit laser and ultrasonic waves simultaneously. Preferably, the acousto-optic generating device 10 can emit any one or several of ultraviolet light of 193 - 337 nm, blue light of 488 nm, green light of 514 nm, red light of 633 nm, near-infrared light of 1064 nm and adjustable light of 570 - 650 nm, and the frequency of the ultrasonic waves generated by the acousto-optic generating device 10 is 100 kHz to 2 MHz.

[0038] Mode description: 1. Photodynamic therapy (PDT) mode: The laser generator and acousto-optic modulator are in the startup state, while the ultrasonic oscillation circuit and ultrasonic transducer are in the shutdown state. The laser intensity and frequency can be adjusted to appropriate values through the laser intensity adjustment component 20 and laser frequency adjustment component 30, and then the adjusted laser beam is conducted to the diseased part by the laser waveguide device 80. 2. Sonodynamic therapy (SDT): The laser generator and acousto-optic modulator are in the shutdown state, while the ultrasonic oscillation circuit and ultrasonic transducer are in the startup state. The ultrasonic intensity and frequency can be adjusted to appropriate values through the ultrasonic intensity adjustment component 40 and ultrasonic frequency adjustment component 50, and then the adjusted ultrasonic wave is conducted to the diseased part by the ultrasonic waveguide device 90. 3. Photoacoustic dynamic combined therapy mode: The laser generator, acousto-optic modulator, ultrasonic oscillation circuit and ultrasonic transducer are all in the startup state. The laser and ultrasonic wave can be conducted to the diseased part successively or simultaneously through the laser waveguide device 80 and ultrasonic waveguide device 90, and the intensities of the laser and ultrasonic wave can also be adjusted through the laser intensity adjustment component 20, laser frequency adjustment component 30, ultrasonic intensity adjustment component 40 and ultrasonic frequency adjustment component 50. According to clinical comparison, the curative effect of the synchronous photoacoustic dynamic combined therapy mode is better than that of the photodynamic therapy (PDT) mode, sonodynamic therapy (SDT) mode, and asynchronous photoacoustic dynamic combined therapy mode.

[0039] This application combines photoacoustic dynamic technology to provide a portable acousto-optic dynamic device that can be used for non-invasive treatment of superficial and deep tissue diseases simultaneously. Compared with the prior art, it has the technical effects of convenient and simple operation, less dosage of sensitizer, and guaranteed treatment effect.

[0040] Second preferred embodiment

[0041] Please refer to Figure 2 , in this embodiment, another acousto-optic dynamic therapeutic instrument is disclosed, which includes a chassis, an acousto-optic generating device 10, a laser display 60, a photoacoustic waveguide device 100 and a control component. The functions and connection methods of the chassis, acousto-optic generating device 10, laser display 60 and control component are the same as those in the first preferred embodiment. Those skilled in the art can refer to the implementation.

[0042] The acousto-optic generating device 10 in this embodiment includes a laser generator 110, an acousto-optic transmission tunnel 120 and an acousto-optic synchronization component 130; the laser generator 110 is used to emit laser, the acousto-optic synchronization component 130 is used to form a ring array laser source and generate ultrasonic waves through the cooperation of the acousto-optic transmission tunnel 120, and the acousto-optic transmission tunnel 120 is used to transmit the laser and ultrasonic waves generated by the acousto-optic synchronization component 130 and transmit the photoacoustic energy to the photoacoustic waveguide device 100. The photoacoustic waveguide device 100 is used to conduct the photoacoustic energy to the diseased part.

[0043] The cross-section of the acousto-optic transmission tunnel 120 has a regular circular structure; the acousto-optic synchronization component 130 includes a cylindrical portion 1310 and a conical portion 1320, and an annular grating array 1330 that penetrates each other is arranged inside the cylindrical portion 1310 and the conical portion 1320; the acousto-optic synchronization component 130 is arranged inside the acousto-optic transmission tunnel 120 and coincides with the axis of the acousto-optic transmission tunnel 120, and the conical portion 1320 of the acousto-optic synchronization component 130 faces the incident end of the laser.

[0044] The laser generator can be various laser emission components or parts in the prior art, such as lasers or laser diodes, etc. Preferably, the laser generator 110 can emit any one or several of ultraviolet light of 193 - 337 nm, blue light of 488 nm, green light of 514 nm, red light of 633 nm, near-infrared light of 1064 nm, and adjustable light of 570 - 650 nm. The frequency of the ultrasonic waves generated by the acousto-optic synchronization component 130 and the acousto-optic transmission tunnel 120 is between 100 kHz and 2 MHz.

[0045] The acousto-optic transmission tunnel 120 can be any waveguide component or assembly in the prior art that can conduct laser and ultrasonic waves, and preferably uses a metal material such as aluminum material. The photoacoustic waveguide device 100 can be various waveguide devices or parts in the prior art, and preferably uses a flexible waveguide device or part.

[0046] Principle description: The laser beam emitted by the laser generator irradiates on the acousto-optic synchronization component 130, a part of which is reflected by the conical reflecting surface of the conical portion 1320 to the inner surface of the acousto-optic transmission tunnel 120 to form an annular laser spot, and the other part forms Figure 2 the concentric annular laser source shown by the arrow-pointing part. The inner surface of the acousto-optic transmission tunnel 120 generates longitudinal waves, transverse waves, and surface waves under the action of the annular laser spot, and the longitudinal waves, transverse waves, and surface waves are coupled into ultrasonic guided waves during the conduction process. The ultrasonic guided waves and the annular laser source are conducted to the patient's part through the photoacoustic waveguide device 100 to achieve acousto-optic synchronous treatment.

[0047] The photoacoustic dynamic therapy instrument provided in this embodiment can not only be used for non-invasive acousto-optic synchronous treatment of superficial and deep tissue diseases at the same time, but also has technical effects such as uniform energy distribution, good acousto-optic signal synchronization performance, simple operation, and convenient use. At the same time, this embodiment uses an annular laser source as the laser source for acousto-optic synchronous treatment, and also has technical effects such as high energy efficiency, small side effects on the human body, and higher safety performance.

[0048] In another variant embodiment of this embodiment, the acousto-optic generating device 10 further includes a laser beam expander, and the laser beam expander is arranged between the laser generator 110 and the acousto-optic synchronization component 130 for adjusting the radiation pattern of the laser beam.

[0049] In another variant embodiment of the present embodiment, the acousto-optic generating device 10 further includes an acousto-optic modulator for adjusting the intensity and frequency of the concentric ring-shaped laser source formed by the annular grating array 1330.

[0050] The technical solutions and effects of the present application have been elaborated in detail in conjunction with the specification drawings and specific embodiments. It should be noted that the specific embodiments disclosed in the specification are only the preferred embodiments of the present application, and those skilled in the art can develop other embodiments on this basis; any simple deformation and equivalent replacement that do not depart from the innovative concept of the present application are covered by the present application and belong to the protection scope of this patent.

Claims

1. A photoacoustic dynamic therapy instrument, comprising a chassis, characterized in that: It further includes an acousto-optic generating device (10) and a control component; The acousto-optic generating device (10) and the control component are both arranged in the chassis; The acousto-optic generating device (10) is electrically connected to the control component; the acousto-optic generating device (10) can emit laser or ultrasonic wave alone, or can emit laser and ultrasonic wave simultaneously; The acousto-optic generating device (10) includes a laser generator (110), an acousto-optic transmission tunnel (120) and an acousto-optic synchronization component (130); The laser generator (110) is used for emitting laser, the acousto-optic synchronization component (130) is used for forming a ring array laser source and generating ultrasonic wave through the cooperation of the acousto-optic transmission tunnel (120), and the acousto-optic transmission tunnel (120) is used for transmitting the laser and ultrasonic wave generated by the acousto-optic synchronization component (130); The cross section of the acousto-optic transmission tunnel (120) has a circular structure; The acousto-optic synchronization component (130) includes a cylindrical part (1310) and a conical part (1320), and an annular grating array (1330) that is mutually penetrated is arranged inside the cylindrical part (1310) and the conical part (1320); The acousto-optic synchronization component (130) is arranged inside the acousto-optic transmission tunnel (120), and the axes of the acousto-optic synchronization component (130) and the acousto-optic transmission tunnel (120) coincide with each other, and the conical part (1320) of the acousto-optic synchronization component (130) faces the incident end of the laser; The acousto-optic generating device (10) further includes a laser beam expander, and the laser beam expander is arranged between the laser generator (110) and the acousto-optic synchronization component (130) for adjusting the radiation pattern of the laser beam.

2. The photoacoustic dynamic therapy instrument according to claim 1, wherein: The acousto-optic generating device (10) includes a laser generator, an acousto-optic modulator, an ultrasonic oscillation circuit and an ultrasonic transducer; The laser generator and the ultrasonic oscillation circuit are electrically connected to the control component, the laser generator is used for emitting laser, the acousto-optic modulator is used for adjusting the laser emitted by the laser generator, the ultrasonic oscillation circuit is used for generating ultrasonic oscillation, and the ultrasonic transducer is used for converting the ultrasonic oscillation generated by the ultrasonic oscillation circuit into ultrasonic wave.

3. The photoacoustic dynamic therapy instrument according to claim 1, wherein: The acousto-optic generating device (10) further includes an acousto-optic modulator, and the acousto-optic modulator is used for adjusting the intensity and frequency of the concentric ring-shaped laser source formed through the annular grating array (1330).

4. The photoacoustic dynamic therapeutic apparatus according to claim 1, wherein: The acousto-optic generating device (10) can emit one or several of ultraviolet light of 193 - 337 nm, blue light of 488 nm, green light of 514 nm, red light of 633 nm, near-infrared light of 1064 nm and adjustable light of 570 - 650 nm; the frequency of the ultrasonic wave generated by the acousto-optic generating device (10) is 100 kHz to 2 MHz.

5. The photoacoustic dynamic therapy instrument according to any one of claims 1 - 4, wherein: The photoacoustic dynamic therapy instrument further includes a laser intensity adjustment component (20), a laser frequency adjustment component (30), an ultrasonic intensity adjustment component (40), and an ultrasonic frequency adjustment component (50); The laser intensity adjustment component (20), the laser frequency adjustment component (30), the ultrasonic intensity adjustment component (40), and the ultrasonic frequency adjustment component (50) are all arranged inside and / or on the chassis; The laser intensity adjustment component (20), the laser frequency adjustment component (30), the ultrasonic intensity adjustment component (40), and the ultrasonic frequency adjustment component (50) are all electrically connected to the control component.

6. The photoacoustic dynamic therapy instrument according to any one of claims 1-4, characterized in that: The photoacoustic dynamic therapy instrument further includes a laser display (60), an ultrasonic display (70), a laser waveguide device (80), and an ultrasonic waveguide device (90); The laser display (60), the ultrasonic display (70), the laser waveguide device (80), and the ultrasonic waveguide device (90) are all arranged inside and / or on the chassis; The laser display (60) and the ultrasonic display (70) are both electrically connected to the control component, and the laser waveguide device (80) and the ultrasonic waveguide device (90) are both electrically connected to the acousto-optic generating device (10).

7. The photoacoustic dynamic therapy instrument according to any one of claims 1-4, characterized in that: The photoacoustic dynamic therapy instrument further includes a photoacoustic waveguide device (100); the photoacoustic waveguide device (100) is used for transmitting laser and / or ultrasonic waves.

Images