A left atrial appendage occlusion device

Abstract

The present invention discloses a left atrial appendage occlusion device, comprising: a delivery catheter; a suction catheter disposed within the delivery catheter, one end of the suction catheter being connected to a suction port, the suction port being capable of fitting against the left atrial wall to form an airtight passage; a fastener provided at one end of the suction port, the fastener being used for ligating the left atrial appendage; a releasable and retractable support frame disposed within the suction catheter, the support frame being used for supporting the left atrial appendage; a support filter sleeved on the proximal end of the support frame, being a radially collapsible mesh stent, the support filter being used for supporting the inner wall of the left atrial appendage and capable of capturing thrombi. The present invention uses the support frame in cooperation with the suction device to cause partial invagination of the left atrial appendage, and the support frame can adaptively change according to the morphology of the inner wall of the left atrial appendage at the release position, ensuring that during the application of suction pressure, the inner wall of the left atrial appendage collapses orderly and enters the left atrium in a predetermined manner. The use of the support filter is beneficial for capturing the thrombi trapped therein during the retraction of the support frame.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and particularly to a left atrial appendage occlusion device. Background Art

[0002] There are 33 million people suffering from stroke globally every year, and 20% of them are caused by non-valvular atrial fibrillation (NVAF), which is a life-threatening arrhythmia disease. In the normal sinus rhythm of a person, the left atrial appendage rarely forms thrombus due to its normal contractile ability. However, during atrial fibrillation, the left atrial appendage significantly enlarges and loses effective regular contractions, resulting in blood stasis in the left atrial appendage and making it extremely easy to form thrombus. 90% of strokes in patients with non-valvular atrial fibrillation are caused by these thrombi traveling with the blood through the aorta to the brain.

[0003] Anticoagulant therapy is currently the standard method for preventing stroke complications in atrial fibrillation. However, anticoagulant therapy has certain limitations. For example, some patients cannot receive anticoagulation due to the existence of anticoagulation contraindications or relative contraindications, or anticoagulants are easily affected by drugs and foods, increasing the detection trouble, making it impossible for some patients to adhere to anticoagulant therapy for a long time. In addition, anticoagulant therapy itself also has bleeding complications, which reduce the long-term anticoagulation adherence rate of patients and limit the role played by anticoagulant therapy.

[0004] Simultaneously removing or ligating and closing the left atrial appendage during cardiac surgery is simple and easy. Therefore, many doctors advocate removing or ligating and closing the left atrial appendage during cardiac surgery for such patients. However, for simply removing or ligating and closing the left atrial appendage, the surgical trauma surface is very large, and surgical operations are not suitable. In 1996, Odell et al. reported the technique of closing the left atrial appendage through thoracoscopy to prevent atrial fibrillation embolism. Since it greatly reduces the surgical trauma and risk, closing the left atrial appendage through thoracoscopy has received extensive attention. However, when performing the operation of closing the left atrial appendage through thoracoscopy, an incision still needs to be made in the chest cavity, and the trauma is relatively large.

[0005] Percutaneous left atrial appendage occlusion is a new method for non-pharmacological prevention of thromboembolism in patients with atrial fibrillation. Its principle of action is to deliver a occluder through a catheter into the left atrial appendage via a blood vessel, using the occluder to block the blood flow between the left atrial appendage and the left atrium, while preventing the thrombus generated in the left atrial appendage from entering the atrium. After a period of time, the surface of the occluder becomes endothelialized, thus solving the problem of thrombus in the left atrial appendage entering the left atrium and reducing the risk of stroke. Due to the rich pectinate muscles and trabeculae attached to the inner wall of the left atrial appendage, the inner wall is thin, the depth of the left atrial appendage varies among different populations, the orifice of the left atrial appendage is mostly a non-circular flat structure, and the orifice of the left atrial appendage forms a certain bending angle with its inner cavity. Due to the complex structure of the left atrial appendage, it is difficult to completely close it with the currently marketed devices on the market, and blood clots may leak from the gap between the device and the left atrial appendage into the brain. Another risk of these devices is that thromboembolism related to the device may form due to foreign body implants remaining in the heart, and some implanted occluding devices also have the risk of falling off after being implanted into the human body, posing a huge safety hazard.

[0006] In view of this, there is an urgent need to improve the existing left atrial appendage occlusion devices to ensure good occlusion effect, less harm to patients and no risk of falling off. Summary of the Invention

[0007] The present invention discloses a left atrial appendage occlusion device for solving the problems that the existing left atrial appendage occlusion devices are difficult to completely occlude the left atrial appendage and the occlusion devices have the risk of falling off.

[0008] To solve the above problems, the present invention adopts the following technical solutions:

[0009] Provide a left atrial appendage occlusion device, comprising:

[0010] A delivery catheter for introducing into the human body through a blood vessel;

[0011] A suction catheter disposed within the delivery catheter, one end of the suction catheter being connected to a suction port, the suction port being capable of forming an airtight channel in contact with the left atrial wall;

[0012] The suction port is provided with a fastener at the end remote from the suction catheter, the fastener being used to ligate the left atrial appendage;

[0013] A releasable and retractable support frame is disposed within the suction catheter, the support frame being used to support the left atrial appendage;

[0014] A support filter is sleeved on the proximal end of the support frame, being a radially collapsible mesh stent, the support filter being used to support the inner wall of the left atrial appendage and capable of capturing thrombus.

[0015] In the above scheme, the support frame changes from a gathered state to an expanded state after being released from the suction catheter, and the support frame can undergo adaptive deformation when supporting the left atrial appendage, and the expanded support frame can fit the inner wall of the left atrial appendage.

[0016] In the above solution, the support frame includes a central axis and a plurality of connecting rods, and the connecting rods extend radially outward from the central axis.

[0017] In the above scheme, the connecting rod includes a first support rod, a second support rod and a third support rod, the first support rod is connected to the central axis, the second support rod is connected to the first support rod, the third support rod is connected to the second support rod, two of the first support rods and two of the second support rods form a quadrilateral, and the end of the third support rod away from the central axis is bent.

[0018] In the above scheme, the support filter includes a plurality of elastic rods, which extend radially outward and enclose the support filter. A through hole is provided at the bottom of the support filter, and a first film is provided on the support filter.

[0019] In the above solution, the support frame and the support filter can move axially respectively.

[0020] In the above scheme, a first guide is provided in the suction duct and connected to the support frame for releasing and recovering the support frame; a second guide is also provided in the first guide, and the second guide is connected to the support filter for releasing and recovering the support filter.

[0021] In the above scheme, the suction port is a mesh structure with a second film provided on the outer periphery, which can be radially collapsed and accommodated in the delivery catheter.

[0022] In the above solution, the end of the suction port away from the delivery catheter is trumpet-shaped.

[0023] In the above solution, the fastener includes an elastic ring and a retaining element, and the elastic ring is releasably arranged on the suction port through the retaining element.

[0024] In the above scheme, the elastic ring includes a suture, a coupling element and a locking element. The coupling element is arranged at one end of the suture. The locking elements are arranged in plurality and are evenly distributed on the suture. Each locking element is used to pass through the coupling element and be clamped and fixed.

[0025] In the above solution, the engagement element is a ring or a sleeve.

[0026] In the above solution, the locking element includes a first end and a second end, the size of the first end is smaller than that of the second end, and the first end and the second end can sequentially pass through the engaging element.

[0027] In the above solution, a break point portion is provided on the suture line for separating a part of the suture line after the fastener ligates the left atrial appendage.

[0028] In the above solution, a resection device is provided in the delivery catheter.

[0029] The technical solution adopted by the present invention can achieve the following beneficial effects:

[0030] (1) Using the support frame in cooperation with the suction device to make a part of the left atrial appendage invaginate. The support frame has excellent morphological self - adaptability and can adaptively change according to the specific anatomical morphology of the specific inner wall of the left atrial appendage at the release position, so that the support frame fully contacts the distal inner wall of the left atrial appendage, which is applicable to the left atrial appendage with a shallow mouth or a multi - lobed anatomical morphology. Thus, it is ensured that during the application of the suction pressure, the inner wall of the left atrial appendage collapses orderly and enters the left atrium in a predetermined manner.

[0031] (2) The fastener is ligated and fastened, which can effectively prevent the fastener from falling off, has a good fastening effect, and can be used for left atrial appendages of different shapes, with a wide range of applications.

[0032] (3) A support filter is also provided on the support frame, which is beneficial to capture the thrombus trapped in it during the process of withdrawing the support frame, improving the effectiveness and safety of left atrial appendage occlusion.

[0033] (4) By controlling the axial displacement of the support frame and the support filter respectively through the first guiding member and the second guiding member, when entering the left atrial appendage, the distance between the support frame and the support filter increases, and when withdrawing the support frame and the support filter, the distance decreases, which is beneficial to guiding the captured thrombus into the bottom of the support filter, with a better capture effect and an improved safety of the device during use. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following will briefly introduce the drawings required for the description of the embodiments. These drawings form a part of the present invention. The schematic embodiments of the present invention and their explanations explain the present invention and do not constitute an improper limitation to the present invention. In the drawings:

[0035] Figure 1 It is a schematic diagram of the left atrial appendage occlusion device disclosed in Embodiment 1 of the present invention;

[0036] Figure 2 It is a schematic diagram of the support frame of the left atrial appendage occlusion device disclosed in Embodiment 1 of the present invention;

[0037] Figure 3 The front view of the support filter of the left atrial appendage occlusion device disclosed in Embodiment 1 of the present invention;

[0038] Figure 4 The top view of the support filter of the left atrial appendage occlusion device disclosed in Embodiment 1 of the present invention;

[0039] Figure 5 The schematic diagram of the elastic loop of the left atrial appendage occlusion device disclosed in another preferred embodiment of the present invention;

[0040] Figure 6 The schematic diagram of the delivery catheter of the left atrial appendage occlusion device disclosed in another preferred embodiment of the present invention;

[0041] Figure 7 The schematic diagram of the left atrial appendage occlusion device disclosed in Embodiment 1 of the present invention placed in the left atrial appendage;

[0042] Figure 8 The schematic diagram of the left atrial appendage when the left atrial appendage occlusion device disclosed in Embodiment 1 of the present invention is in use;

[0043] Figure 9 The schematic diagram after ligation of the left atrial appendage disclosed in Embodiment 1 of the present invention;

[0044] Figure 10 The schematic diagram of the left atrial appendage occlusion device disclosed in Embodiment 2 of the present invention;

[0045] Figure 11 The schematic diagram of the left atrial appendage occlusion device disclosed in Embodiment 2 of the present invention placed in the left atrial appendage;

[0046] Figure 12 The schematic diagram of the left atrial appendage when the left atrial appendage occlusion device disclosed in Embodiment 2 of the present invention is in use;

[0047] Figure 13 The schematic diagram of the retraction of the support frame and the support filter in the left atrial appendage occlusion device disclosed in Embodiment 2 of the present invention.

[0048] Specifically, it includes the following reference numerals:

[0049] Suction catheter - 10; left atrial appendage - 20; support frame - 30; fastener - 40; delivery catheter - 50; support filter - 60; suction port - 11; central axis - 31; first strut - 32; second strut - 33; third strut - 34; first guide - 35; elastic loop - 41; cutting device - 51; first film - 61; second guide - 62 suture - 411; engagement element - 412; locking element - 413; break point - 414. Detailed Description of the Invention

[0050] To make the objectives, technical solutions and advantages of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below in conjunction with specific embodiments of the present invention and the corresponding drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without making creative efforts fall within the scope of protection of the present invention.

[0051] Example 1

[0052] As Figure 1 、 Figure 7 and Figure 8 shown, the left atrial appendage occlusion device provided by the present invention includes:

[0053] A delivery catheter 50 for introducing into the human body through a blood vessel; a suction catheter 10 disposed within the delivery catheter 50. One end of the suction catheter 10 is connected to a suction port 11, and the suction port 11 can be attached to the left atrial wall to form an airtight channel. A fastener 40 is provided at one end of the suction port 11 away from the suction catheter 10, and the fastener 40 is used to ligate the left atrial appendage 20. A releasable and retrievable support frame 30 is disposed within the suction catheter 10. The support frame 30 is used to support the left atrial appendage 20. After being released from the suction catheter 10, the support frame 30 changes from a gathered state to an expanded state, and the support frame 30 can undergo adaptive deformation when supporting the left atrial appendage 20. The expanded support frame 30 can be attached to the inner side wall of the left atrial appendage 20. By providing the support frame 30 to support the left atrial appendage 20, it is not necessary to aspirate the entire left atrial appendage into the left atrium, the aspiration time is short, and it is applicable to left atrial appendages of different shapes. A support filter 60 is sleeved on the central axis 31 of the support frame 30. The support filter 60 can support the inner wall of the left atrial appendage 20 and can capture thrombi. It can prevent thrombi inside the left atrial appendage 20 from entering the left atrium during the device operation process, and is beneficial to capturing the thrombi trapped therein by using the support filter 60 during the process of retracting the support frame 30, improving the effectiveness and safety of left atrial appendage occlusion.

[0054] A first guide 35 is disposed within the suction catheter 10 and is connected to the support frame 30 for releasing and retrieving the support frame 30.

[0055] Specifically, the support frame 30 extends into the left atrium through the suction port 11 and expands to a predetermined shape to effectively support the left atrial appendage wall. Thus, when the suction device applies pressure to the left atrial appendage 20, the part of the left atrial appendage wall at the distal end of the left atrial appendage 20 that is supported by the support frame 30 will not immediately collapse into the left atrium. The tissue at the distal end of the left atrial appendage 20 that is not supported and the tissue near the opening of the left atrial appendage will preferentially collapse, and the tissue near the opening of the left atrial appendage 20 will preferentially invaginate into the left atrium. Subsequently, during the process of retracting the support frame 30 by manipulating the first guide 35, more left atrial appendage tissue will orderly invaginate.

[0056] The support frame 30 has excellent morphological self - adaptability and can adaptively change according to the specific anatomical morphology of the specific inner wall of the left atrial appendage 20 at the release position, enabling the support frame 30 to fully contact the inner wall of the left atrial appendage. It is particularly suitable for left atrial appendages with shallow openings or multi - lobed anatomical morphologies, thus ensuring that during the application of suction pressure, the inner wall of the left atrial appendage collapses and enters the left atrium in an orderly manner according to a predetermined pattern.

[0057] As Figure 2 shown, the support frame 30 includes a central shaft 31 and multiple connecting rods. The connecting rods extend radially outwardly and divergently from the central shaft 31.

[0058] Specifically, the connecting rods include a first strut 32, a second strut 33, and a third strut 34. The first strut 32 is connected to the central shaft 31, the second strut 33 is connected to the first strut 32, and the third strut 34 is connected to the second strut 33. Two first struts 32 and two second struts 33 form a quadrilateral, enabling the support frame 30 to elongate along the length direction of the suction catheter 10 or expand radially outward along the suction catheter 10, enabling the support frame 30 to be retracted into the suction catheter 10 and expand to a diameter larger than that of the suction catheter after release. The end of the third strut 34 away from the central shaft 31 is bent, and the tip curls inward, forming a three - dimensional structure similar to a petal shape. The part of the left atrial appendage 20 in contact with the support frame 30 is a curved surface, avoiding the tip from contacting the left atrial appendage 20. The first strut 32, the second strut 33, and the third strut 34 are all made of medical metal tubing with elastic and shape - memory properties, which are integrally laser - cut and shaped through heat treatment.

[0059] In this embodiment, the flexibility of the first support rod 32 is greater than or equal to the flexibility of the second support rod 33, and the flexibility of the second support rod 33 is greater than the flexibility of the third support rod 34. By setting it in this way, the entire support frame 30 has both high flexibility and high resilience, and can adapt to the left atrial appendage cavity of different anatomical forms, and has excellent morphological adaptability. In addition, when the suction pressure is applied to the left atrial appendage cavity, the order of adaptive deformation of various parts of the support frame 30 is: the first support rod 32, the second support rod 33, and the third support rod 34, thereby allowing the tissue near the opening of the left atrial appendage 20 to collapse into the left atrium first, preventing the inner wall tissue of the left atrial appendage 20 from disorderly collapsing into the left atrium, affecting the closing effect of the left atrial appendage 20.

[0060] like Figure 3 and Figure 4 As shown, the support filter 60 is configured as follows: a through hole is provided in the middle of the support filter 60, a plurality of elastic rods extend radially outward through the through hole and surround the support filter 60, a first film 61 is provided on the support filter 60, and the outer periphery can be attached to the inner wall of the left atrial appendage 20. The first film 61 is a gas permeable film, which can filter the blood in the left atrial appendage to intercept thrombus, and is applicable to left atrial appendages 20 of different shapes and ensures filtering effect.

[0061] The suction port 11 is a mesh structure with a second film on the periphery and is configured to extend out of the delivery catheter 50 or be retracted into the delivery catheter 50. The second film has good sealing properties, ensuring that the suction port 11 can fit with the left atrium wall to form an airtight passage.

[0062] In this embodiment, the suction port 11 is preferably trumpet-shaped away from the suction catheter 10 , so as to facilitate joining to the left atrium wall around the opening of the left atrial appendage 20 .

[0063] In this embodiment, the fastener 40 preferably includes an elastic ring 41 and a retaining element (not shown in the figure), and the elastic ring 41 is releasably arranged on the suction port 11 through the retaining element. After the retaining element releases the elastic ring 41, the elastic ring 41 radially shrinks and becomes thicker, and can be fastened to the invaginated left atrial appendage tissue.

[0064] The method for using the left atrial appendage occlusion device provided in this embodiment is as follows:

[0065] The delivery catheter 50 is introduced into the human body through a blood vessel until it reaches the left atrium. The aspiration catheter 10 extends from the delivery catheter 50, and the aspiration port 11 extends from the aspiration catheter 10 and engages with the left atrial wall around the opening of the left atrial appendage 20. The support frame 30 and the support filter 60 extend from the aspiration port 11. The aspiration device starts to aspirate, and the left atrial appendage 20 is recessed along the contour of the support frame 30. The support frame 30 and the support filter 60 are withdrawn into the delivery catheter 50. The retaining element on the fastener 40 is released, and the elastic loop 41 is sleeved on the recessed left atrial appendage and radially becomes smaller under the action of the recovery of elastic deformation, thereby tightly ligating the left atrial appendage 20. The aspiration port 11 is withdrawn into the delivery catheter 50, and then the delivery catheter 50 is removed from the human body, as Figure 9 shown, completing the occlusion process of the left atrial appendage.

[0066] As Figure 5 shown, in another preferred embodiment, the elastic loop 41 includes a suture 411, an engaging element 412, and a locking element 413. The engaging element 412 is disposed at one end of the suture 411. The locking elements 413 are provided in plurality and are evenly distributed on the suture 411. Each locking element 413 can pass through the engaging element 412 under the action of tension and be snap-fixed.

[0067] Preferably in this embodiment, the suture 411 is elastic, having a good ligation and fastening effect. The engaging element 412 is a ring or a sleeve. The locking element 413 includes a first end and a second end. The size of the first end is smaller than that of the second end, and the first end and the second end can sequentially pass through the engaging element. The locking element 413 is provided in a frustum shape or a conical shape, which facilitates the locking element 413 to pass through the engaging element 412 and can prevent the locking element 413 from detaching after passing through the engaging element 412, that is, the tightening process of the elastic loop 41 is irreversible, preventing detachment.

[0068] Preferably in this embodiment, a break point portion 414 is provided on the suture 411 for separating the redundant part of the suture 411 after the fastener 40 ligates the left atrial appendage 20. And the redundant suture 411 is withdrawn from the body, avoiding excessive suture 411 remaining in the body. There is no need for other devices to cut again, and the operation is convenient.

[0069] Specifically, after the aspiration of the left atrial appendage 20 is completed, the support frame 30 and the support filter 60 are withdrawn into the delivery catheter 50. The retaining element on the fastener 40 is released, and the elastic loop 41 is sleeved on the recessed left atrial appendage. The suture 411 is pulled, and the locking element 413 passes through the engaging element 412 and is snap-fixed to complete the tight ligation of the left atrial appendage. The redundant suture 411 is separated through the break point portion, and the suture 411 and the aspiration port 11 are sequentially withdrawn into the delivery catheter 50, and then the delivery catheter 50 is removed from the human body to complete the occlusion process of the left atrial appendage.

[0070] As Figure 6 shown, in another preferred embodiment, a cutting device 51 is disposed within the delivery catheter 50 for cutting the suture 411. This avoids accidentally pulling and breaking the broken end of the suture 411 during fastening, making it safer.

[0071] Specifically, after the elastic loop 41 fastens and ligates the left atrial appendage 20, the suture 411 is pulled at the cutting device 51, and the cutting device 51 cuts the excess suture 411.

[0072] Example 2

[0073] As Figure 10 shown, different from Embodiment 1, in this embodiment, a second guide member 62 is further provided and connected to the support filter 60 for releasing and retrieving the support filter 60. The second guide member 62 is sleeved within the first guide member 35 and can respectively control the axial movement of the support frame 30 and the support filter 60.

[0074] As Figure 11 shown, when entering the left atrial appendage 20, the distance between the support frame 30 and the support filter 60 is increased. During the suction process, the thrombus in the left atrial appendage 20 will be suctioned into the support filter. Due to the large distance between the support frame 30 and the support filter 60, it is easier to observe whether the thrombus has completely fallen into the support filter 60, avoiding the situation where the thrombus lands on the support frame 30 and cannot be captured.

[0075] As Figure 12 shown, after capturing the thrombus, the distance between the support frame 30 and the support filter 60 is reduced, which is beneficial for suctioning the left atrial appendage 20, enabling the distal end of the left atrial appendage 20 to more invaginate into the left atrium.

[0076] As Figure 13 shown, after completing the suction, the first guide member 35 first controls the support frame 30 to retract, and then the first guide member 35 and the second guide member respectively control the support frame 30 and the support filter 60 to retract together. Since the thrombus has fallen to the bottom of the support filter, and at the same time, due to the retraction of the support frame 30 and the support filter 60 forming a mutually clamping effect, the thrombus is retrieved better during retraction, effectively avoiding accidental detachment of the thrombus into the left atrium. The distance between the support frame 30 and the support filter 60 can be adjusted according to the shape of the left atrial appendage 20, making the operation more flexible, with better use effects, and improving the use safety of the device.

[0077] The present invention has the following advantages:

[0078] (1) Use a support frame in cooperation with a suction device to invaginate a part of the left atrial appendage. The support frame has excellent morphological self - adaptability and can adaptively change according to the specific anatomical morphology of the specific inner wall of the left atrial appendage at the release position, enabling the support frame to fully contact the distal inner wall of the left atrial appendage. It is applicable to the left atrial appendage with a shallow mouth or a multi - lobed anatomical morphology, so as to ensure that during the application of suction pressure, the inner wall of the left atrial appendage collapses orderly in a predetermined manner and enters the left atrium.

[0079] (2) The fastener uses a ligation - type fastening, which can effectively prevent the fastener from falling off, has a good fastening effect, and can be used for left atrial appendages of different shapes, with a wide range of applications.

[0080] (3) A support filter is also provided on the support frame, which is beneficial to capturing the thrombus trapped therein by using the support filter during the process of withdrawing the support frame, improving the effectiveness and safety of left atrial appendage occlusion.

[0081] (4) Control the axial displacement of the support frame and the support filter respectively through the first guide member and the second guide member. When entering the left atrial appendage, the distance between the support frame and the support filter increases, and when retracting the support frame and the support filter, the distance decreases, which is beneficial to guiding the captured thrombus into the bottom of the support filter, with a better capture effect and an improved safety of device use.

[0082] The embodiments of the present invention have been described above in conjunction with the accompanying drawings. However, the present invention is not limited to the above - mentioned specific embodiments. The above - mentioned specific embodiments are merely illustrative rather than restrictive. Under the inspiration of the present invention, those of ordinary skill in the art can also make many forms without departing from the purpose of the present invention and the scope protected by the claims, and all of them belong to the protection scope of the present invention.

Claims

1. A left atrial appendage occlusion device, characterized in that, it comprises: a delivery catheter for introducing into the human body through a blood vessel; a suction catheter disposed within the delivery catheter, one end of the suction catheter being connected to a suction port, the suction port being capable of fitting against the left atrial wall to form an airtight passage; the suction port is provided with a fastener at one end remote from the suction catheter, the fastener being used for ligating the left atrial appendage; a releasable and retractable support frame is provided within the suction catheter, the support frame being used for supporting the left atrial appendage; the support frame has morphological self - adaptability and can adaptively change according to the specific anatomical morphology of the inner wall of the left atrial appendage at the release position, such that the inner wall of the left atrial appendage is recessed along the contour of the support frame and collapses orderly in a predetermined manner into the left atrium, and the predetermined collapse manner of the left atrial appendage includes: the tissue near the opening of the left atrial appendage collapses preferentially into the left atrium; a support filter sleeved on the proximal end of the support frame, the distance between the support frame and the support filter can be adjusted according to the shape of the left atrial appendage; the support filter is a radially collapsible mesh stent, and the support filter is used for supporting the inner wall of the left atrial appendage and can capture thrombus; the support frame and the support filter can move axially respectively; the support frame and the support filter can be withdrawn into the delivery catheter after the left atrial appendage is recessed.

2. The left atrial appendage occlusion device according to claim 1, characterized in that, after being released from the suction catheter, the support frame changes from a gathered state to an expanded state, and the support frame can undergo adaptive deformation when supporting the left atrial appendage, and the expanded support frame can fit against the inner wall of the left atrial appendage.

3. The left atrial appendage occlusion device according to claim 1, characterized in that, the support frame includes a central axis and a plurality of connecting rods, and the connecting rods extend radially outward from the central axis.

4. The left atrial appendage occlusion device according to claim 3, characterized in that, the connecting rod includes a first strut, a second strut and a third strut, the first strut is connected to the central axis, the second strut is connected to the first strut, the third strut is connected to the second strut, two of the first struts and two of the second struts form a quadrilateral, and the end of the third strut remote from the central axis is bent.

5. The left atrial appendage occlusion device according to claim 1, characterized in that, the support filter includes a plurality of elastic rods, and the plurality of elastic rods extend radially outward and enclose to form the support filter, the bottom of the support filter has through - holes, and a first film is provided on the support filter.

6. The left atrial appendage occlusion device according to claim 1, characterized in that, a first guide is provided within the suction catheter and is connected to the support frame for releasing and retrieving the support frame; a second guide is further provided within the first guide, and the second guide is connected to the support filter for releasing and retrieving the support filter.

7. The left atrial appendage occlusion device according to claim 1, characterized in that, The suction port is a mesh structure, and a second film is provided on the outer periphery, and it can be radially collapsed and received in the delivery catheter.

8. The left atrial appendage occlusion device according to claim 7, wherein, one end of the suction port away from the delivery catheter is flared.

9. The left atrial appendage occlusion device according to any one of claims 1-8, wherein, the fastener includes an elastic ferrule and a retaining element, and the elastic ferrule is releasably arranged on the suction port through the retaining element.

10. The left atrial appendage occlusion device according to claim 9, wherein, the elastic ferrule includes a suture, a joining element and a locking element, the joining element is arranged at one end of the suture, the locking elements are arranged in a plurality and are evenly distributed on the suture, and each of the locking elements is used to pass through the joining element and be snap-fitted and fixed.

11. The left atrial appendage occlusion device according to claim 10, wherein, the joining element is a ring or a sleeve.

12. The left atrial appendage occlusion device according to claim 10, wherein, the locking element includes a first end portion and a second end portion, the size of the first end portion is smaller than that of the second end portion, and the first end portion and the second end portion can sequentially pass through the joining element.

13. The left atrial appendage occlusion device according to claim 10, wherein, a break point portion is provided on the suture for separating a part of the suture after the fastener ligates the left atrial appendage.

14. The left atrial appendage occlusion device according to claim 9, wherein, a resection device is provided in the delivery catheter.

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