Blood purification device

Abstract

The blood purification device (1) comprises: a blood circuit (2) for causing the patient's blood to circulate extracorporeally; a liquid supply circuit (4) for supplying supply liquid to the blood circuit (2) or to a blood purifier (3) arranged in the blood circuit (2); a heater (65, 75) arranged in the liquid supply circuit (4) for heating the supply liquid, wherein the heater (65, 75) is constructed in a manner of clamping a heating circuit (65) as a part of the liquid supply circuit, and the heater (65, 75) comprises: a heater (654) arranged It is disposed on a clamping surface (651a) of a clamping heating circuit (66); a heater temperature detecting portion, which can detect the temperature of the heater (654); a liquid temperature detecting temperature sensor (656), which is disposed at a position separated from the above-mentioned heater (654) in the clamping surface (651a), and is disposed at a position abutting against the above-mentioned heating circuit (66) on the downstream side of the portion heated by the heater (654) in the liquid delivery direction when the heating circuit (66) is clamped, so as to detect the temperature of the supply liquid flowing in the heating circuit (66).

Description

Technical Field

[0001] The invention relates to a blood purification device. Background Art

[0002] In a blood purification device, if the temperature of the dialysate or supplemental fluid is low, the temperature of the blood returned to the patient decreases, causing the patient to feel cold, etc. Therefore, in the past, a blood purification device having a warmer for heating the supply fluid such as the dialysate or supplemental fluid was used (for example, see Patent Document 1).

[0003] Prior art literature

[0004] Patent Literature

[0005] Patent Document 1: Japanese Patent Application Publication No. 2017-80266 Summary of the invention

[0006] Problems to be solved by the invention

[0007] In a blood purification device, it is known that there is a temperature sensor for detecting the liquid temperature (for example, a clip-on temperature sensor, etc.) independently of the warmer, and the warmer is controlled so that the temperature of the supply liquid is the set temperature. However, in such a blood purification device, sometimes the temperature sensor for detecting the liquid temperature is forgotten to be installed, or it cannot be installed normally. In this case, there is a risk that the liquid temperature of the supply liquid such as the dialysate and the supplemental liquid cannot be correctly controlled, and it is desired to improve it.

[0008] Therefore, an object of the present invention is to provide a blood purification apparatus in which a problem of adjusting the temperature of a supply liquid is unlikely to occur.

[0009] Technical solutions to solve problems

[0010] The invention described in Technical Solution 1 relates to a blood purification device, which includes: a blood circuit for allowing a patient's blood to circulate extracorporeally; a liquid supply circuit, which supplies supply liquid to the blood circuit or to a blood purifier arranged in the above-mentioned blood circuit; a heater, which is arranged in the above-mentioned liquid supply circuit to heat the supply liquid, wherein the above-mentioned heater is constructed in a manner of clamping a heating circuit as a part of the above-mentioned liquid supply circuit, and the above-mentioned heater includes: a heater, which is arranged on a clamping surface that clamps the above-mentioned heating circuit; a heater temperature detection part, which can detect the temperature of the above-mentioned heater; a temperature sensor for liquid temperature detection, which is arranged at a position separated from the above-mentioned heater in the above-mentioned clamping surface, and is arranged at a position abutting the above-mentioned heating circuit on the downstream side of the part heated by the above-mentioned heater in the liquid delivery direction when clamping the above-mentioned heating circuit, and can detect the temperature of the supply liquid flowing in the above-mentioned heating circuit.

[0011] The invention described in Technical Solution 2 relates to the blood purification device described in Technical Solution 1, wherein the blood purification device includes a heater installation detection unit, which detects whether the heating circuit is installed on the heater based on: the temperature of the heater detected by the heater temperature detection unit and the temperature of the supply liquid detected by the liquid temperature detection temperature sensor.

[0012] The invention described in Technical Solution 3 relates to the blood purification device described in Technical Solution 2, wherein, after the heater starts heating, when the temperature detected by the heater temperature detection unit reaches a specified upper limit temperature, and the increase in the detected temperature of the temperature sensor for detecting the liquid temperature from the start of heating by the heater is less than a specified abnormality judgment threshold, the heater installation detection unit determines that the heating circuit is not installed on the heater.

[0013] The invention described in Technical Solution 4 relates to a blood purification device described in any one of Technical Solutions 1 to 3, wherein the blood purification device includes a heater control unit, which controls the temperature of the above-mentioned heater in a manner such that the temperature of the supply liquid detected by the above-mentioned liquid temperature detection temperature sensor is a pre-set set temperature, and the above-mentioned heater control unit is constructed in a manner such that an upper limit value of the above-mentioned heater temperature can be set corresponding to the supply liquid used.

[0014] The invention described in claim 5 relates to the blood purification device described in claim 4, wherein the heater control unit is configured to change the upper limit temperature depending on whether the supply liquid used contains protein components.

[0015] The invention described in Technical Solution 6 relates to the blood purification device described in Technical Solution 5, wherein when the supply liquid used contains protein components, the above-mentioned upper limit temperature is set to be lower than 46 degrees, and when the supply liquid used does not contain protein components, the above-mentioned upper limit temperature is above 46 degrees.

[0016] The invention described in claim 7 is directed to the blood purification device according to any one of claims 1 to 6, wherein the heater temperature detection unit is a heater temperature sensor provided in a heating region of the heater.

[0017] Effects of the Invention

[0018] According to the invention described in claim 1, a blood purification device can be provided in which poor regulation of the liquid temperature of the supply liquid is unlikely to occur.

[0019] According to the invention described in technical solution 2, it is possible to detect whether the heating circuit is installed on the above-mentioned heater.

[0020] According to the invention described in technical solution 3, it is possible to accurately detect whether the heating circuit is installed on the above-mentioned heater.

[0021] According to the invention described in claims 4 to 6, when a supply liquid containing a protein component is used, coagulation of the protein component can be suppressed.

[0022] According to the invention described in claim 7, the heater temperature detection unit can be realized easily and at low cost. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 This is a schematic structural diagram of a blood purification device according to one embodiment of the present invention;

[0024] Figure 2 To express Figure 1 A diagram of the appearance of a blood purification device;

[0025] Figure 3 This is a top view of the heating circuit;

[0026] Figure 4A is a three-dimensional diagram of a dialysate warmer;

[0027] Figure 4B for Figure 4A A magnified view of part A;

[0028] Figure 5A A graph showing changes in detection values ​​of the heater temperature sensor and the liquid temperature detection temperature sensor in a state where the heating circuit is not installed;

[0029] Figure 5BThis is a graph showing changes in the detection values ​​of the heater temperature sensor and the liquid temperature detection temperature sensor in a state where the heating circuit is installed. DETAILED DESCRIPTION

[0030] [Implementation Method]

[0031] Hereinafter, embodiments of the present invention will be described with reference to the accompanying drawings.

[0032] Figure 1 FIG. 2 is a schematic diagram of the blood purification device of this embodiment. Figure 1 As shown, the blood purification device 1 comprises: a blood circuit 2 for extracorporeally circulating the patient's blood; a blood purifier 3 disposed in the blood circuit 2 for purifying the blood; a liquid supply circuit 4 for supplying a supply liquid to the blood purifier 3 or the blood circuit 2; and a drainage circuit 5 for discharging drainage liquid from the blood purifier 3. The blood circuit 2, the liquid supply circuit 4 (dialysis fluid circuit 6 and supplementary fluid circuit 7 described later) and the drainage circuit 5 are constructed using flexible tubes.

[0033] An arterial puncture needle 21 is provided at one end of the blood circuit 2, and a venous puncture needle 22 is provided at the other end of the blood circuit 2. In addition, in the blood circuit 2, a first bubble detection device 23, a blood pump 24, a blood purifier 3, a gas-liquid separator 25, and a second bubble detection device 26 are provided in order from the arterial puncture needle 21 side to the venous puncture needle 22 side. The first bubble detection device 23 and the second bubble detection device 26 have bubble detection sensors for detecting bubbles, and have a mechanism for clamping (sandwiching and closing) the blood circuit 2 when bubbles are detected.

[0034] The blood pump 24 is composed of a peristaltic pump that allows blood to flow toward the blood purifier 3 side by straightening the tube. The blood purifier 3 is also called a dialyzer, and purifies the blood by contacting the blood and the dialysate through a blood purification membrane not shown in the figure. The gas-liquid separator 25 is constructed in a manner that removes bubbles and allows only liquid to pass through the venous puncture needle 22 side.

[0035] In this embodiment, in order to perform various treatments by the blood purification device 1, the liquid supply circuit 4 includes two circuits, namely, a dialysate circuit 6 for supplying a dialysate and a supplementary liquid circuit 7 for supplying a supplementary liquid. However, the blood purification device 1 may also include only one of the dialysate circuit 6 and the supplementary liquid circuit 7.

[0036] A dialysate storage bag 61 for storing dialysate is connected to one end of the dialysate circuit 6. The other end of the dialysate circuit 6 is connected to the dialysate inlet of the blood purifier 3. In the dialysate circuit 6, a dialysate transfer pump 62, a dialysate subdivision chamber 63 for temporarily storing dialysate, a dialysate pump 64, and a dialysate heater 65 are sequentially arranged from the dialysate storage bag 61 side to the blood purifier 3 side.

[0037] The dialysate transfer pump 62 and the dialysate pump 64 are composed of peristaltic pumps that make the dialysate flow by straightening the tube. The dialysate transfer pump 62 is used to transfer the dialysate in the dialysate storage bag 61 to the dialysate subdivision chamber 63. The dialysate pump 64 is used to make the dialysate in the dialysate subdivision chamber 63 flow to the side of the blood purifier 3. By having the dialysate subdivision chamber 63, the dialysate storage bag 61 can be replaced without interrupting the treatment. The dialysate warmer 65 is used to heat the dialysate to an appropriate temperature in a manner that does not lower the temperature of the blood returned to the patient, and the dialysate warmer 65 is one form of the warmer of the present invention. The details of the dialysate warmer 65 will be described later.

[0038] One end of the replenishing liquid circuit 7 is connected to a replenishing liquid storage bag 71 for storing replenishing liquid. In the replenishing liquid circuit 7 downstream of the replenishing liquid storage bag 71, a replenishing liquid transfer pump 72, a replenishing liquid subdividing chamber 73 for temporarily storing replenishing liquid, a replenishing liquid pump 74, a replenishing liquid heater 75, and a replenishing liquid gas-liquid separator 76 are sequentially arranged.

[0039] In addition, the replenishing liquid circuit 7 forms a branch at the downstream of the replenishing liquid gas-liquid separator 76, and the end of the front replenishing liquid circuit 7a of the replenishing liquid circuit 7 as one branch is connected to the blood circuit 2 between the blood purifier 3 and the blood pump 24. The front auxiliary liquid circuit 7a is provided with a front auxiliary liquid pump 77. The end of the rear replenishing liquid circuit 7b of the replenishing liquid circuit 7 as the other side of the branch is connected to the gas-liquid separator 25 of the blood circuit 2.

[0040] The replenishing liquid delivery pump 72, the replenishing liquid pump 74 and the replenishing liquid pump 77 are composed of a peristaltic pump, which squeezes the tube to make the dialysate flow. The replenishing liquid transfer pump 72 is used to transfer the replenishing liquid in the replenishing liquid storage bag 71 to the replenishing liquid subdivision chamber 73. The replenishing liquid pump 74 is used to make the replenishing liquid in the replenishing liquid subdivision chamber 73 flow on the blood circuit 2 side. The front auxiliary liquid pump 77 is driven when the "front auxiliary liquid" of the replenishing liquid is supplied to the blood circuit 2 on the upstream side of the blood purifier 3. When the front auxiliary liquid pump 77 is not driven, the replenishing liquid transported by the auxiliary liquid pump 74 passes through the rear auxiliary liquid circuit 7b to supply the replenishing liquid to the blood circuit 2 (here, the gas-liquid separator 25) on the downstream side of the blood purifier 3.

[0041] Since the supplementary liquid subdividing chamber 73 is provided, the supplementary liquid storage bag 71 can be replaced without interrupting treatment. The supplementary liquid warmer 75 is used to warm the supplementary liquid to an appropriate temperature so that the temperature of the blood returned to the patient does not drop, and is one embodiment of the warmer of the present invention. The supplementary liquid gas-liquid separator 76 is used to separate and remove bubbles from the supplementary liquid.

[0042] One end of the drainage circuit 5 is connected to the drainage outlet of the blood purifier 3. In the drainage circuit 5 downstream of the blood purifier 3, a drainage pump 51, a drainage subdivision chamber 52 for temporarily storing drainage, and a discharge pump 53 are sequentially arranged. The other end of the drainage circuit 5 constitutes a drainage outlet 54 for discharging drainage to the outside of the device.

[0043] The drainage pump 51 and the discharge pump 53 are composed of peristaltic pumps that make the dialysate flow by smoothing the tube. The drainage pump 51 is used to send the drainage to the drainage subdivision chamber 52. The discharge pump 53 is used to discharge the drainage in the drainage subdivision chamber 52 to the drainage outlet 54 side.

[0044] In addition, the blood purification device 1 has a water removal amount detection unit 10, which detects the water removal amount based on the supply amount of the supply liquid and the discharge amount of the discharge liquid. The water removal amount detection unit 10 has the above-mentioned subdivided chambers 63, 73, 52, a load meter 8 as a weight detection mechanism that can detect the total weight of each subdivided chamber 63, 73, 52, and a water removal amount calculation unit 91.

[0045] The load meter 8 is configured to detect the total weight of the dialysate subdividing chamber 63, the supplemental fluid subdividing chamber 73, and the drainage subdividing chamber 52. The detection value of the load meter 8 is output to the control device 9.

[0046] The water removal amount calculation unit 91 detects the water removal amount by detecting the time change of the detection value of the load meter 8. The water removal amount calculation unit 91 is mounted in the control device 9 and is realized by appropriately combining a calculation element such as a CPU, a memory, a storage device, software, an interface, and the like.

[0047] In addition, the blood purification device 1 includes a water removal control unit 92, which corrects the pump speed (pump flow rate) of one or both of the liquid supply pump (dialysis fluid pump 64 and replenishing fluid pump 74) and the drainage pump 51 in a manner that the water removal amount detected by the water removal amount detection unit 10 is consistent with the target water removal amount. The water removal control unit 92 is mounted in the control device 9 and is realized by appropriately combining computing elements such as a CPU, a memory, a storage device, software, an interface, etc.

[0048] (Heater and its control)

[0049] Here, the dialysate heater 65 and its control will be described. Although the description of the supplemental fluid heater 75 and its control will be omitted here, it has the same structure as the dialysate heater 65 described below and performs the same control as the dialysate heater 65.

[0050] Figure 2 It is a figure which shows the external appearance of the blood purification device 1. Figure 3 This is a top view of the heating circuit. Figure 4A is a three-dimensional diagram of a dialysate warmer 65, Figure 4B This is an enlarged view of its A part. Figure 2 , Figure 3 , Figure 4A and Figure 4B As shown, the dialysate warmer 65 is provided on the side of the blood purification apparatus 1 so as to be openable and closable.

[0051] The dialysate heater 65 is configured to sandwich a heating circuit 66 which is a part of the dialysate circuit 6. Figure 3 As shown, the heating circuit 66 is also called a heating bag, for example, by overlapping and welding two flexible sheets to form a flow path 66a. The flow path 66a is formed in a curved manner, one end of the flow path 66a is an inlet 66b for the dialysate, and the other end of the flow path 66a is an outlet 66c for the dialysate. The tube 6a extending from the dialysate pump 64 is connected to the inlet 66b, and the tube 6b extending to the blood purifier 3 is connected to the outlet 66c. The heating circuit 66 is made of a material softer than the tubes 6a and 6b, so if it is forgotten to be installed on the dialysate heater 65 and left alone, not only will the dialysate not be heated, but it will also be damaged for some reason, or the influence of external pressure or the accumulation of dialysate in the heating circuit 66 will cause a risk of the dialysate with a flow rate different from the desired flow rate being supplied to the blood purifier 3. Therefore, when the user forgets to attach the warming circuit 66 to the dialysate warmer 65 , it is desirable to notify the user of this fact.

[0052] The dialysate warmer 65 includes a fixed portion 651 fixed to the side of the blood purification device 1, a hinge portion 653 provided at the bottom of the fixed portion 651, and a cover portion 652 rotatably provided on the fixed portion 651, and is configured in a manner that a heating circuit 66 is clamped between the fixed portion 651 and the cover portion 652. On the clamping surface (the surface that clamps the heating circuit 66) 651a of the fixed portion 651, a plate-shaped heater 654 is provided, and the heater 654 is used to heat the heating circuit 66 and heat the dialysate circulating in the heating circuit 66. In addition, here, the case where the heater 654 is provided on the fixed portion 651 is described, but the heater 654 may also be provided on the cover portion 652, or may be provided on both the fixed portion 651 and the cover portion 652.

[0053] The heater 654 is provided so as to sandwich the flow path 66a (the meandering portion) of the heating circuit 66 when sandwiching the heating circuit 66. In addition, here, the heater 654 is provided on both the fixing portion 651 and the cover portion 652, but the heater 654 may be provided on only one side.

[0054] The dialysate warmer 65 also includes a heater temperature sensor 655 as a warmer temperature detection unit capable of detecting the temperature of the heater 654 , and a liquid temperature detection temperature sensor 656 capable of detecting the temperature of the dialysate flowing in the warming circuit 66 .

[0055] The heater temperature sensor 655 is provided in the heating area of ​​the heater 654 and detects the temperature of the heater 654. For example, it is a thermistor. Here, the case where the heater temperature sensor 655 is mounted on the fixing portion 651 side (the side where the heater 654 is provided), but it may also be mounted on the cover portion 652 side (the side where the heater 654 is not provided). In addition, a plurality of heater temperature sensors 655 may also be provided. In addition, the heater temperature detection portion is not limited to the heater temperature sensor 655. For example, a current sensor for detecting the current supplied to the heater 654 may also be used. In this case, the temperature of the heater 654 is detected (estimated) based on the current value detected by the current sensor.

[0056] The temperature sensor 656 for liquid temperature detection is arranged at a position separated from the heater 654 in the clamping surface 651a, and is arranged at a position that abuts against the heating circuit 66 on the downstream side of the liquid feeding direction than the portion heated by the heater 654 when the heating circuit 66 is clamped. That is, in the blood purification device 1, if the heating circuit 66 is installed on the dialysate heater 65, even if no other operation is performed, the temperature sensor 656 for liquid temperature detection abuts against the heating circuit 66 and is in a state where the temperature of the dialysate can be detected. Therefore, it is difficult to make human errors such as forgetting to install the sensor or causing bad conditions during installation, as in the case where the temperature sensor 656 for liquid temperature detection is separately provided with the dialysate heater 65. The temperature sensor 656 for liquid temperature detection is, for example, a thermistor.

[0057] In order to suppress the influence of heat from the heater 654, it is preferable that the temperature sensor 656 for detecting the liquid temperature is provided at a position that is thermally isolated from the heater 654 as much as possible. In the present embodiment, the member covering the periphery of the heater 654 (the member constituting the clamping surface 651a around the heater 654) is formed of a resin member having high thermal insulation, and the temperature sensor 656 for detecting the liquid temperature is provided at a position separated from the heater 654 via the member. The temperature sensor 656 for detecting the liquid temperature abuts against the surface of the heating circuit 66 and detects the temperature of the abutting portion. Since the heating circuit 66 is formed of a relatively thin sheet, the temperature of the surface of the heating circuit 66 is substantially equal to the temperature of the dialysate flowing in the heating circuit 66.

[0058] The blood purification device 1 has a heater control unit 93, which controls the temperature of the heater 654 in such a way that the temperature of the dialysate detected by the temperature sensor 656 for liquid temperature detection is a preset set temperature. The heater control unit 93 sets the heater target temperature according to the difference between the set temperature and the temperature of the dialysate, for example, and controls the temperature of the heater 654 (control of the supply current, etc.) in such a way that the temperature of the heater 654 detected by the heater temperature sensor 655 is the heater target temperature. The heater control unit 93 is mounted on the control device 9 and is realized by appropriately combining a computing element such as a CPU, a memory, a storage device, software, an interface, etc.

[0059] The heater control unit 93 may be configured in such a manner that an upper limit value (referred to as an upper limit temperature) of the temperature of the heater 654 can be set according to the supply fluid (dialysis fluid, supplement fluid) used. In addition, the heater control unit 93 may change the upper limit temperature depending on whether the supply fluid used contains a protein component.

[0060] Specifically, in a treatment mode called PE (plasma exchange therapy), PA (plasma adsorption) or DFPP (double filtration plasma exchange), fresh frozen plasma containing protein components such as apramide is used as a supply liquid. Protein components such as albumin have the property of coagulating into white when heated at a high temperature of 46 degrees or more. The temperature at which the protein component coagulates varies depending on the protein component and is around 41°C to 46°C. Therefore, when the supply liquid used contains a protein component, the upper limit temperature is preferably lower than 46°C, more preferably below 40°C. On the other hand, in continuous hemodialysis (CHD), CHDF (continuous hemodiafiltration) or CHF (continuous hemofiltration), a dialysate that does not contain a protein component is used, so the upper limit temperature can be 46°C or higher.

[0061] In addition, for example, when heating the low-temperature supply liquid below 20° C., it is sometimes necessary to heat the temperature of the heater 654 to 46° C. or higher. However, if the heating amount is too large, there is a risk of burns when the user touches the surface of the heater 65, 75 during tidying, etc., so it is preferable to control the temperature of the heater 654 to a temperature without the risk of burns, for example, below 51° C. The heater control unit 93 stops the heating of the heater 654, for example, when the detected temperature of the heater temperature sensor 655 reaches 51° C. or higher.

[0062] In addition, the temperature of the supply liquid at the time when the blood merges with the blood circuit 2 for extracorporeal circulation must be controlled to be less than 46°C. This is because when the supply liquid at a temperature of 46°C or higher comes into contact with the blood, a phenomenon called hemolysis occurs in which red blood cells are destroyed. Therefore, it is necessary to monitor the detection value of the liquid temperature detection temperature sensor 656 so that the temperature of the supply liquid at the time of merging with the blood circuit 2 is less than 46°C. For example, the heater control unit 93 stops the heating of the heater 654 when the detection temperature of the liquid temperature detection temperature sensor 656 is 46°C or higher.

[0063] As described above, since the heater temperature sensor 655 has the function of monitoring overheating of the heater 654, and the liquid temperature detection temperature sensor 656 has the function of monitoring overheating of the supply liquid, it is preferred to independently set the heater temperature sensor 655 and the liquid temperature detection temperature sensor 656 as heater temperature detection units.

[0064] In addition, the blood purification device 1 has a heater installation detection unit 94, which detects whether the heater 65, 75 is installed in the heating circuit 66 based on the temperature of the heater 654 detected by the heater temperature sensor 655 and the temperature of the dialysate detected by the liquid temperature detection temperature sensor 656. The heater installation detection unit 94 is mounted on the control device 9 and is realized by appropriately combining a computing element such as a CPU, a memory, a storage device, software, an interface, etc.

[0065] When the dialysate pump 64 is driven and the temperature of the heater 654 is raised but the temperature of the dialysate does not rise, the heater installation detector 94 detects that the heating circuit 66 is not installed in the heater 65 or 75 (that is, the heating circuit 66 is forgotten to be installed).

[0066] Figure 5A Graph showing the changes in the detection values ​​of the heater temperature sensor 655 and the liquid temperature detection temperature sensor 656 when the heating circuit 66 is not installed. Here, the flow rate of the dialysate is 1000 mL / h. Figure 5AAs shown, when the heating circuit 66 is not installed, even if the heater temperature is increased, the detection value of the liquid temperature detection temperature sensor 656 does not increase, and the detection value of the liquid temperature detection temperature sensor 656 does not reach the set temperature.

[0067] Figure 5B Graph showing changes in the detection values ​​of the heater temperature sensor 655 and the liquid temperature detection temperature sensor 656 when the heating circuit 66 is installed. Figure 5A The same is true for the case of 1000 mL / h. Figure 5B As shown, in the state where the heating circuit 66 is installed, the detection value (liquid temperature) of the liquid temperature detection temperature sensor 656 increases with the increase of the heater temperature, and the detection value (liquid temperature) of the liquid temperature detection temperature sensor 656 reaches the set temperature. In this way, the detection value of the liquid temperature detection temperature sensor 656 changes greatly between the state where the heating circuit 66 is installed and the state where it is not installed. The heater installation detection unit 94 detects whether the heater 65, 75 is installed in the heating circuit 66 by using the change in the detection value of the liquid temperature detection temperature sensor 656 caused by the presence or absence of the heating circuit 66.

[0068] More specifically, after the heater 65, 75 starts heating, when the temperature detected by the heater temperature sensor 655 reaches a predetermined upper limit temperature, and when the increase in the temperature detected by the liquid temperature detection temperature sensor 656 from the start of heating by the heater 65, 75 does not exceed a predetermined abnormality determination threshold, the heater installation detection unit 94 determines that the heating circuit 66 is not installed on the heater 65, 75. In other words, when the temperature of the heater 654 rises sufficiently and the temperature detected by the liquid temperature detection temperature sensor 656 does not rise sufficiently, the heater installation detection unit 94 determines that the heating circuit 66 is not installed on the heater 65, 75. In addition, the specific algorithm for determining that the heating circuit 66 is not installed on the heater 65, 75 is not limited to this. For example, the following processing may also be performed, and the processing is as follows: based on the temperature of the supply liquid before heating, the detected temperature of the heater temperature sensor 655 and the flow rate of the supply liquid, the temperature of the supply liquid at the position where the liquid temperature detection temperature sensor 656 is provided is estimated, and when the deviation between the estimated temperature and the actual temperature detected by the liquid temperature detection temperature sensor 656 is greater than a specified threshold value, it is determined that the heating circuit 66 is not installed on the heater 65, 75.

[0069] Furthermore, the blood purification device 1 has an alarm unit 11 that issues an alarm when the heater installation detection unit 94 detects that the heating circuit 66 is forgotten to be installed. The alarm unit 11 has an alarm device 111 that generates an alarm by light, sound, vibration, or a display 111a such as a monitor (see Figure 2 ) and an alarm control unit 112, which controls the alarm device 111. The alarm device 111 is composed of, for example, a buzzer that emits a warning sound and a display that displays a warning message. The alarm control unit 112, for example, sounds the buzzer and displays a warning message on the display. The alarm control unit 112 is mounted on the control device 9 and is implemented by appropriately combining a computing element such as a CPU, a memory, a storage device, software, an interface, and the like.

[0070] (Functions and Effects of Implementation Methods)

[0071] As described above, the blood purification device 1 of this embodiment includes a heater 65, 75 for heating the supply liquid; a heater 654 which is configured in a manner of clamping the heating circuit 66 which is a part of the liquid supply circuit 4 and is arranged on the clamping surface 651a for clamping the heating circuit 66; a heater temperature sensor 655 which is a heater temperature detection portion capable of detecting the temperature of the heater 654; and a liquid temperature detection temperature sensor 656 which is arranged at a position separated from the heater 654 on the clamping surface 651a and which, when clamping the heating circuit 66, abuts against the heating circuit 66 which is on the downstream side of the portion heated by the heater 654 in the liquid delivery direction and can detect the temperature of the supply liquid flowing in the heating circuit 66.

[0072] By mounting both the heater temperature detection unit (heater temperature sensor 655) and the liquid temperature detection temperature sensor 656 on the heater 65, 75, a blood purification device 1 is realized that can suppress the bad situation of forgetting to install the sensor or installing it, and it is difficult to cause the bad situation of adjusting the liquid temperature of the supply liquid. In addition, using the two sensors 655, 656, it is possible to detect the situation that the heating circuit 66 is forgotten to be installed on the heater 65, 75. In addition, in the case where the liquid temperature detection temperature sensor 656 is separately provided from the heater 65, 75, it is impossible to judge whether the deviation between the heater temperature and the liquid temperature is caused by forgetting to install the heating circuit 66, or by forgetting to install the liquid temperature detection temperature sensor 656 or installing it poorly. In addition, when the temperature sensor 656 for detecting the liquid temperature is separately provided from the heater 65, 75, the temperature between the heater 65, 75 and the installation position of the temperature sensor 656 for detecting the liquid temperature is affected by the outside air temperature, which becomes the main cause of the error in the liquid temperature control. However, in this embodiment, since the temperature sensor 656 for detecting the liquid temperature is provided in the heater 65, 75, it is not easily affected by the outside air temperature, and a higher-precision liquid temperature adjustment (heater control) corresponding to the supply liquid used can be performed. In addition, by judging the presence or absence of the temperature sensor 656 for detecting the liquid temperature and the heater temperature detection unit required for the original treatment, it is not necessary to provide additional sensors, etc., and the function of judging whether the heating circuit 65, 75 is installed can be realized at a low cost.

[0073] (Summary of Implementation Methods)

[0074] Next, the technical concept grasped from the above-described embodiments will be described by citing the reference numerals in the embodiments. However, the reference numerals in the following description do not limit the constituent elements in the claims to the components specifically shown in the embodiments.

[0075] [1] A blood purification device (1) comprises: a blood circuit (2) for allowing a patient's blood to circulate extracorporeally; a liquid supply circuit (4) for supplying a supply liquid to the blood circuit (2) or to a blood purifier (3) disposed in the blood circuit (2); a heater (65, 75) disposed in the liquid supply circuit (4) for heating the supply liquid, the heater (65, 75) being configured to clamp a heating circuit (66) which is a part of the liquid supply circuit (4), the heater (65, 75) comprising: a heater (654), the heater (654) is arranged on a clamping surface (651a) that clamps the above-mentioned heating circuit (66); a heater temperature detecting portion, the heater temperature detecting portion can detect the temperature of the above-mentioned heater (654); a temperature sensor (656) for detecting liquid temperature, the temperature sensor (656) for detecting liquid temperature is arranged at a position separated from the above-mentioned heater (654) in the above-mentioned clamping surface (651a), and is arranged at a position abutting against the above-mentioned heating circuit (66) on the downstream side of the portion heated by the above-mentioned heater (654) in the liquid delivery direction when clamping the above-mentioned heating circuit (66), so as to detect the temperature of the supply liquid flowing in the above-mentioned heating circuit (66).

[0076] [2] Relates to the blood purification device (1) described in [1], wherein the blood purification device (1) includes a heater installation detection unit (94), and the heater installation detection unit (94) detects whether the heating circuit (66) is installed on the heater (65, 75) based on the temperature of the heater (654) detected by the heater temperature detection unit and the temperature of the supply liquid detected by the liquid temperature detection temperature sensor (656).

[0077] [3] Relates to the blood purification device (1) described in [2], wherein, after the heater (65, 75) starts heating, when the temperature detected by the heater temperature detection unit reaches a specified upper limit temperature, and the increase in the detection temperature of the temperature sensor (656) for detecting the liquid temperature from the start of heating by the heater (65, 75) does not exceed a specified abnormality judgment threshold, the heater installation detection unit (94) determines that the heating circuit (66) is not installed on the heater (65, 75).

[0078] [4] Relates to a blood purification device (1) as described in any one of [1] to [3], wherein the blood purification device (1) includes a heater control unit (93), which controls the temperature of the heater (654) in such a manner that the temperature of the supply liquid detected by the temperature sensor (656) for detecting the liquid temperature is a pre-set set temperature, and the heater control unit (93) is constructed in such a manner that an upper limit value of the heater temperature can be set corresponding to the supply liquid used.

[0079] [5] The blood purification device 1 described in [4], wherein the heater control unit (93) is configured to change the upper limit temperature depending on whether the supply liquid used contains protein components.

[0080] [6] Relates to the blood purification device (1) described in [5], wherein when the supply liquid used contains protein components, the above-mentioned upper limit temperature is set to be lower than 46 degrees, and when the supply liquid used does not contain protein components, the above-mentioned upper limit temperature is above 46 degrees.

[0081] [7] A blood purification device 1 according to any one of [1] to [6], wherein the heater temperature detection unit is a heater temperature sensor (655) provided in a heating area of ​​the heater (654).

[0082] The embodiments of the present invention have been described above, but the embodiments described above are not intended to be limiting.

[0083] Inventions limited by claims. In addition, it should be noted that all combinations of features described in the embodiments are not necessarily limited to means for solving the problems of the invention. The present invention can be implemented with appropriate modifications within the scope of the gist thereof.

[0084] Description of the label:

[0085] Reference numeral 1 denotes a blood purification device;

[0086] Reference numeral 2 denotes a blood circuit;

[0087] Reference numeral 3 denotes a blood purifier;

[0088] Reference numeral 4 denotes a liquid supply circuit;

[0089] Reference numeral 5 indicates a drain circuit;

[0090] Reference numeral 6 denotes a dialysate circuit;

[0091] Reference numeral 65 denotes a dialysate warmer (warmer);

[0092] Reference numeral 654 denotes a heater;

[0093] Reference numeral 655 denotes a temperature sensor for a heater;

[0094] Reference numeral 656 denotes a temperature sensor for detecting the liquid temperature;

[0095] Reference numeral 66 denotes a heating circuit;

[0096] Reference numeral 7 denotes a replenishing liquid circuit;

[0097] Reference numeral 75 denotes a replenishing liquid heater (heater)

[0098] Reference numeral 9 denotes a control device;

[0099] Reference numeral 93 denotes a heater control unit;

[0100] Reference numeral 94 denotes a heater installation detection unit.

Claims

1. A blood purification device, comprising: A blood circuit that circulates the patient's blood extracorporeally; A liquid supply circuit that supplies a supply liquid to a blood circuit or a blood purifier disposed in the blood circuit; A heater, which is disposed in the liquid supply circuit and heats the supply liquid; The heater is configured to sandwich a heating circuit as a part of the liquid supply circuit. The above-mentioned heater comprises: A heater, the heater being arranged on a clamping surface clamping the heating circuit; a heater temperature detection unit capable of detecting the temperature of the heater; a temperature sensor for detecting the liquid temperature, the temperature sensor for detecting the liquid temperature being arranged at a position separated from the heater in the clamping surface and being arranged at a position abutting against the heating circuit on the downstream side of the portion heated by the heater in the liquid feeding direction when the heating circuit is clamped, and being capable of detecting the temperature of the supply liquid flowing in the heating circuit, The blood purification device includes a heater control unit, which controls the temperature of the heater in such a manner that the temperature of the supply liquid detected by the temperature sensor for detecting the liquid temperature is a preset set temperature. The heater control unit sets the upper limit of the temperature of the heater to less than 46 degrees when the supplied liquid used is a treatment mode of plasma exchange therapy, plasma adsorption or secondary filtration plasma exchange containing protein components, and sets the upper limit of the temperature of the heater to more than 46 degrees when the supplied liquid used is a treatment mode of continuous hemodialysis, continuous hemodiafiltration or continuous hemofiltration containing no protein components. The heater comprises: a fixing portion; and a cover portion rotatably disposed on the fixing portion. The heater, the heater temperature detection unit, and the temperature sensor for detecting the liquid temperature are arranged on the clamping surface of the fixing unit. The blood purification device includes a heater installation detection unit, which detects whether the heating circuit is installed on the heater based on the temperature of the heater detected by the heater temperature detection unit and the temperature of the supply liquid detected by the liquid temperature detection temperature sensor.

2. The blood purification device according to claim 1, wherein: After the heater starts heating, the heater installation detection unit determines that the heating circuit is not installed on the heater when the temperature detected by the heater temperature detection unit reaches the specified upper limit temperature and the increase in the detected temperature of the temperature sensor for detecting the liquid temperature from the start of heating by the heater is less than the specified abnormality judgment threshold.

3. The blood purification device according to claim 1 or 2, wherein: The heater temperature detection unit is a heater temperature sensor provided in a heating region of the heater.

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