Sample analyzers and specific protein detection methods

Abstract

This application provides a sample analyzer and a method for detecting specific proteins. The sample analyzer includes a sampling device, a hemolysis reagent supply device, a latex tank, an information reading device, a control unit, a reaction chamber, and a detection device. The sampling device draws up a blood sample and dispenses it. The hemolysis reagent supply device provides the hemolysis reagent required for the test. The latex tank holds reagent bottles, each with a label carrying identification information, including at least the type of reagent in the bottle. The information reading device reads the label on the reagent bottle to obtain the identification information. The controller controls the sampling device to sample and dispense the latex reagent from the reagent bottle based on the identification information. The reaction chamber receives the blood sample, latex reagent, and hemolysis reagent dispensed by the sampling device to form a mixed sample required for the test. The detection device detects the mixed sample to obtain the specific protein concentration of the blood sample. The sample analyzer of this application can accurately draw up the required latex reagent.

Description

Technical Field

[0001] This application relates to the field of medical device technology, and in particular to a sample analyzer and a method for detecting specific proteins. Background Technology

[0002] Automated specific protein analyzers are commonly used instruments in clinical laboratory testing. Automated specific protein analyzers can be used to detect C-reactive protein (CRP) and serum amyloid A (SAA). Due to the specificity of specific proteins, different latexes are required for different proteins. For example, CRP latex is used to detect CRP, and SAA latex is used to detect SAA. In use, the latex is stored in an insulated chamber within the analyzer. The sampling needle draws reagent from the reagent bottle containing the latex and adds it to the sample for subsequent reaction and measurement. Traditional multi-channel automated specific protein analyzers have multiple latex placement chambers, each for different types of latex. However, specific compartments can only hold the corresponding latex; they cannot be mixed. For example, compartment A can only hold CRP latex, and compartment B can only hold SAA latex. Incorrect placement of latex will lead to incorrect latex aspiration. Summary of the Invention

[0003] This application provides a sample analyzer, the sample analyzer comprising:

[0004] A sampling device for collecting blood samples and dispensing the blood samples;

[0005] A latex container is used to hold a reagent bottle containing latex reagents. The reagent bottle has a label with identification information, wherein the identification information includes at least the type of reagent in the reagent bottle.

[0006] Information reading device, the information reading device being used to read the label on the reagent bottle to obtain identification information;

[0007] The controller controls the sampling device to sample and dispense the latex reagent in the reagent bottle according to the identification information;

[0008] The reaction chamber receives the blood sample and latex reagent to form the mixed sample required for the test; and

[0009] A detection device is used to detect the mixed sample to obtain the specific protein concentration of the blood sample.

[0010] This application also provides a method for detecting a specific protein, wherein the method is applied to a sample analyzer, and the method includes:

[0011] The sampling device draws blood samples from the sampling position and dispenses the blood samples into the reaction tank;

[0012] The controller controls the sampling device to draw latex reagent from the reagent bottle and dispense it into the reaction tank based on the identification information of the information reading device. The identification information includes at least the type of reagent in the reagent bottle.

[0013] The reaction chamber receives the blood sample to be tested and the latex reagent to form the mixed sample required for the test. The reaction chamber, the sampling position where the blood sample is located, and the latex chamber where the reagent bottle is located are arranged in a straight line.

[0014] The detection device tests the mixed sample to obtain the specific protein concentration of the blood sample.

[0015] Compared to traditional technologies, the sample analyzer provided in this application is equipped with an information reading device that can read the label on the reagent bottle and obtain identification information including the type of reagent. The controller controls the sampling device to sample and dispense the latex reagent in the reagent bottle according to the identification information. This can accurately draw the latex reagent required for the detection of specific proteins, avoid drawing the wrong latex reagent, and thus improve the success rate of detecting the concentration of specific proteins in blood samples. Attached Figure Description

[0016] To more clearly illustrate the structural features and effects of this application, a detailed description is provided below in conjunction with the accompanying drawings and specific embodiments. Obviously, the drawings described below are some embodiments of this application. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0017] Figure 1 This is a schematic diagram of a sample analyzer provided in one embodiment of this application.

[0018] Figure 2 for Figure 1 The circuit block diagram of the sample analyzer in the image.

[0019] Figure 3 for Figure 1 A partial structural diagram of the latex tank in the sample analyzer.

[0020] Figure 4 This is a schematic diagram showing the correspondence between the latex tank and the information reading device in a sample analyzer provided in one embodiment of this application.

[0021] Figure 5 for Figure 3 An exploded view of the latex tank.

[0022] Figure 6This is a cross-sectional schematic diagram of the card carrier reading device.

[0023] Figure 7 This is a schematic diagram showing one configuration of the latex tank and the hatch in one embodiment.

[0024] Figure 8 for Figure 7 This is a schematic diagram showing another configuration of the latex compartment and hatch.

[0025] Figure 9 A flowchart of a specific protein detection method provided in one embodiment of this application.

[0026] Figure 10 This is a schematic diagram showing the locations of the reaction tank, blood sample collection point, and latex chamber used in a specific protein detection method provided in one embodiment of this application.

[0027] Figure 11 This is a schematic diagram of a sampling device provided in one embodiment of this application.

[0028] Figure 12 A flowchart of a specific protein detection method provided for another embodiment of this application. Detailed Implementation

[0029] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of this application, not all of them. All other embodiments obtained by those skilled in the art based on the embodiments of this application without creative effort should fall within the scope of protection of this application.

[0030] In this document, references to "embodiment" or "implementation" mean that a particular feature, structure, or characteristic described in connection with an embodiment may be included in at least one embodiment of this application. The appearance of this phrase in various places throughout the specification does not necessarily refer to the same embodiment, nor is it a mutually exclusive, independent, or alternative embodiment. It will be explicitly and implicitly understood by those skilled in the art that the embodiments described herein can be combined with other embodiments.

[0031] Human blood contains many proteins derived from tissue cells. These are functional proteins, also known as specific proteins. Many diseases can cause changes in the concentration of these proteins; therefore, changes in their concentration can characterize the health status of the person being measured. For example, changes in the concentration of C-reactive protein (CRP) can reflect changes in inflammation in the person being measured. Therefore, it is often necessary to measure the concentration of these proteins and to determine the health status of the person being measured based on these protein concentrations.

[0032] Please see Figures 1 to 3 , Figure 1 A schematic diagram of a sample analyzer provided in one embodiment of this application; Figure 2 for Figure 1 Circuit block diagram of the sample analyzer in the middle; Figure 3 for Figure 1 A partial structural diagram of the latex tank in a sample analyzer is shown below. This application provides a sample analyzer 1, which includes: a sampling device 100, a hemolysis reagent supply device 200, a latex tank 300, an information reading device 400, a controller 800, a reaction cell 500, and a detection device 600. The various components of the sample analyzer 1 are described in detail below. It should be noted that the hemolysis reagent supply device 200 can be selected according to specific projects. Some projects require the use of hemolysis reagents, in which case the sample analyzer includes the hemolysis reagent supply device 200 and receives the hemolysis reagents provided by this device; some projects do not require the use of hemolysis reagents, so the hemolysis reagent supply device 200 may not be included. The sampling device 100 is used to draw blood samples and dispense them. The hemolysis reagent supply device 200 is used to provide the hemolysis reagents required for the testing project. The latex tank 300 is used to hold a reagent bottle 3 containing latex reagents. The reagent bottle 3 has a label carrying identification information, wherein the identification information includes at least the type of reagent in the reagent bottle 3. The information reading device 400 is used to read the label on the reagent bottle 3 to obtain identification information. The controller 800 controls the sampling device 100 to sample and dispense the latex reagent in the reagent bottle 3 according to the identification information. The reaction tank 500 receives the blood sample to be tested dispensed by the sampling device 100, the latex reagent, and the hemolysis reagent provided by the hemolysis reagent providing device 200 to form a mixed sample required for testing. The detection device 600 is used to detect the mixed sample to obtain the specific protein concentration of the blood sample.

[0033] The sampling device 100 may include, but is not limited to, a sampling needle. The blood sample drawn by the sampling device 100 may be, but is not limited to, whole blood or diluted whole blood. The hemolysis reagent providing device 200 may include a syringe or a syringe and tubing connected to the syringe. The hemolysis reagent providing device 200 can provide the hemolysis reagent required for the test. For example, when the test is CRP, the hemolysis agent is R1 reagent. The latex container 300 is used to hold the reagent bottle 3. The reagent bottle 3 carries a tag with identification information, which may be, but is not limited to, a radio frequency identification (RFID) tag. The information reading device 400 reads the tag in the reagent bottle 3 to obtain the identification information. The controller 800 is electrically connected to the information reading device 400 and controls the sampling device 100 to sample and dispense the latex reagent in the reagent bottle 3 according to the identification information. Since the information reading device 400 in the sample analyzer 1 can read the label in the reagent bottle 3 and obtain the identification information, and the controller 800 controls the sampling device 100 to sample and dispense the latex reagent in the reagent bottle 3 according to the identification information, the error of latex reagent aspiration is avoided, thereby avoiding the failure of the detection of specific protein concentration in the blood sample due to the error of latex reagent aspiration.

[0034] In summary, compared with traditional technologies, the sample analyzer 1 provided in this application is equipped with an information reading device 400, which can read the label of the reagent bottle 3 and obtain identification information including the type of reagent. The controller 800 controls the sampling device 100 to sample and dispense the latex reagent in the reagent bottle 3 according to the identification information. This can accurately draw the latex reagent required for the detection of specific proteins, avoid drawing the wrong latex reagent, and thus improve the success rate of detecting the concentration of specific proteins in blood samples.

[0035] Please refer to the following: Figure 4 , Figure 4 This diagram illustrates the correspondence between the latex tank and the information reading device in a sample analyzer provided in one embodiment of this application. The latex tank 300 has N compartments 30, where N ≥ 2 and N is a positive integer. The information reading device 400 includes N sub-reading devices 410, each of which corresponds one-to-one with one of the N compartments 30. Each sub-reading device 410 is used to read the identification information carried on the label of the reagent bottle 3 placed in the corresponding compartment 30.

[0036] The latex container 300 has N compartments 30, each compartment 30 for holding one reagent bottle 3. The reagents in the reagent bottles 3 in each compartment 30 can be the same or different. In the schematic diagram of this embodiment, the latex container 300 is illustrated as having two compartments 30. The number of sub-reading devices 410 in the information reading device 400 is equal to the number of compartments 30 in the latex container 300, and the sub-information reading devices 410 correspond to the compartments 30 to read the labels of the reagent bottles 3 placed in the compartments 30. For example, the sub-information reading devices 410 can be set on one side of the compartment 30. It can be understood that the N sub-information reading devices 410 can be set on the same side of the compartment 30 or on different sides of the compartment 30, which is not limited here.

[0037] The structure of the latex tank 300 in the sample analyzer 1 provided in this application is described in detail below. Please refer to the following: Figures 5 to 6 , Figure 5 for Figure 3 Exploded view of the latex tank; Figure 6 This is a cross-sectional schematic diagram of the card carrier reading device. The latex compartment 300 includes a bracket 310 and N-1 first partitions 320. The N-1 first partitions 320 are connected to the bracket 310, and the N-1 first partitions 320 are made of electromagnetic wave shielding material. The N-1 first partitions 320 are spaced apart, and the bracket 310 and the N-1 first partitions 320 cooperate to form N compartments 30.

[0038] In this embodiment, taking N=2 as an example, when N=2, the latex container 300 includes a first partition 320, and the bracket 310 cooperates with the partition to form two compartments 30. When a compartment 30 is used to place a reagent bottle 3, the bracket 310 can accommodate and fix the reagent bottle 3. Further, the first partition 320 is made of electromagnetic wave shielding material, therefore, the first partition 320 can isolate the labels in the reagent bottles 31 contained in adjacent accommodating spaces 321. When the sub-reading device 410 reads the label in the reagent bottle 3 of the corresponding compartment 30, the sub-reading device 410 will only read the label in the reagent bottle 3 of the corresponding compartment 30, and will not read the labels in the reagent bottles 3 placed in other compartments 30, thereby ensuring the correctness of the labels read by each sub-reading device 410 of the reagent bottles 3 contained in the compartment 30.

[0039] Furthermore, the latex container 300 includes N card plates 330, each card plate 330 is used to carry the sub-reading device 410, and one card plate 330 is used to carry one sub-reading device 410, and different card plates 330 carry different sub-reading devices 410.

[0040] The sub-reading device 410 can be, but is not limited to, an antenna component, and can read the identification information from the labels of reagent bottles 3 placed in the compartment 30 of the sub-reading device 410. The card plate 330 can support the sub-reading device 410 by embedding the sub-reading device 410 within the card plate 330. In other embodiments, the card plate 330 can support the sub-reading device 410 in other ways, such as by placing the sub-reading device 410 on the surface of the card plate 330, as long as the card plate 330 supports the sub-reading device 410. The card plate 330 is made of a non-electromagnetic wave shielding material so that the sub-reading device 410 can communicate with the labels contained in the reagent bottles 3 in the compartment 30.

[0041] Please refer to the following: Figure 7 and Figure 8 , Figure 7 This is a schematic diagram showing one configuration of the latex tank and the hatch in one embodiment. Figure 8 for Figure 7 This is a schematic diagram of another configuration of the latex compartment and its door. The sample analyzer 1 also includes a door 700 that mates with the latex compartment 300. The latex compartment 300 has a refrigerated space 340 and an opening 350 communicating with the refrigerated space 340. The door 700 is used to seal the opening 350. The partition 320 is fixed to the bracket 310, and the card plate 330 and the sub-reading device 410 are all fixed to the door 700.

[0042] The hatch 700 has a first state in which it cooperates with the latex compartment 300 to seal the bracket 310, the first partition 320, and the reagent bottle 3 placed in the compartment 30 within the refrigerated space 340 (see [reference]). Figure 7 The hatch 700 also has a second state in which it is separated from the latex tank 300 (see...). Figure 8 ).

[0043] The top of the latex compartment 300 is also provided with a through hole 360 ​​penetrating the refrigeration space 340. The number of through holes 360 is equal to the number of compartments 30, and each through hole 360 ​​corresponds to one compartment 30. The through holes 360 allow the sampling needle 140 to pass through to draw reagents from the reagent bottle 3 in the compartment 30. In the schematic diagram of this embodiment, two through holes 360 are used as an example for illustration.

[0044] Please continue reading. Figure 5The hatch 700 has a recess 380 for receiving the card plate 330. The latex compartment 300 also includes a second partition 370. The second partition 370 has N-1 spaced slits 371 that penetrate two opposite surfaces of the second partition 370 and allow one end of the first partition 320 to pass through. The second partition 370 and the first partition 320 cooperate to fill the recess 380, and the second partition 370 is made of a non-electromagnetic wave shielding material.

[0045] The second partition 370 and the first partition 320 cooperate to seal the card plate 330 in the groove 380, preventing moisture in the refrigeration space 340530 of the latex tank 300 from entering the groove 380 and affecting the performance of the readout device 410 in the card plate 330.

[0046] Furthermore, a gap 390 exists between adjacent card plates 330, and the first partition 320 also passes through the gap 390 and protrudes from the surface of the card plate 330 away from the second partition 370. In this embodiment, the first partition 320 protruding from the surface of the card plate 330 away from the second partition 370 through the gap 390 can enhance the isolation effect of the first partition 320 on the sub-reading device 410 in the card plate 330.

[0047] In one embodiment, the controller 800 is further configured to control the sampling device 100 to sample and dispense the latex reagent in the reagent bottle 3 according to the detection items and the identification information.

[0048] Different testing items require different latex reagents. For example, the testing item could be CRP or SAA. For instance, reagent bottle 3 in compartment 30a contains the latex reagent required for CRP testing, while reagent bottle 3 in compartment 30b contains the reagent required for SAA testing. If the testing item is CRP, the information reading device 400 reads the label on reagent bottle 3 and determines that the latex reagent in reagent bottle 3 in compartment 30a is the latex reagent required for CRP testing. Then, the controller 800 controls the sampling device 100 to sample and dispense the latex reagent in reagent bottle 3 in compartment 30a. If the testing item is SAA, the information reading device 400 reads the label on reagent bottle 3 and determines that the latex reagent in reagent bottle 3 in compartment 30b is the latex reagent required for SAA testing. Then, the controller 800 controls the sampling device 100 to sample and dispense the latex reagent in reagent bottle 3 in compartment 30b.

[0049] In one embodiment, the controller 800 is further configured to acquire information on the remaining amount of latex reagent in the reagent bottle 3. The controller acquires the remaining amount of latex reagent in the reagent bottle 3 and adopts a corresponding control strategy based on the remaining amount information. The specific method by which the controller 800 acquires the remaining amount of latex reagent in the reagent bottle 3, and the corresponding control strategy adopted based on the remaining amount information, will be described in detail later.

[0050] The following describes the specific method by which the controller 800 obtains the latex reagent from reagent bottle 3.

[0051] In one embodiment, the identification information also includes the remaining amount of latex reagent in the reagent bottle 3, and the information reading device 400 reads the label on the reagent bottle 3 to obtain the remaining amount information.

[0052] Understandably, the identification information includes not only the type of latex reagent in the reagent bottle 3, but also the remaining amount of latex reagent in the reagent bottle 3. In other words, the label's identification information carries the type of latex reagent and the remaining amount of latex reagent, and the information reading device 400 can obtain the remaining amount information by reading the label in the reagent bottle 3.

[0053] In one embodiment, after the sampling device 100 samples the latex reagent in the reagent bottle 3, the information reading device 400 is further configured to write new remaining information to the label based on the remaining information before sampling and the amount of latex reagent consumed during sampling, so as to update the remaining information in the identification information.

[0054] By updating the remaining information in the identification information, the remaining information in the identification is made consistent with the actual remaining amount of latex reagent in the reagent bottle 3, so that the controller 800 can control the sampling device 100 to draw latex reagent from the corresponding reagent bottle 3 according to the read remaining information.

[0055] In another embodiment, the controller 800 is further configured to determine the remaining amount of latex reagent in the reagent bottle 3 based on the number of times the latex reagent in the reagent bottle 3 has been sampled and a preset number of times the latex reagent in the reagent bottle 3 can be sampled.

[0056] Specifically, the latex reagent in reagent bottle 3 can be used a preset number of times. If the number of times the latex reagent has been sampled is less than the preset number, then the remaining amount of latex reagent is not zero, and the latex reagent in reagent bottle 3 can be sampled again. If the number of times the latex reagent has been sampled is equal to the preset number, then the remaining amount of latex reagent in reagent bottle 3 is zero, and it cannot be sampled again. For example, if the preset number of times the latex reagent in reagent bottle 3 can be sampled is 100, and if the latex reagent in reagent bottle 3 has been sampled 35 times, then 100-35=65, and the latex reagent in reagent bottle 3 can be used again for 65 times. In this embodiment, the controller 800 records and updates the number of samplings each time the latex reagent is sampled.

[0057] In conjunction with the method for obtaining the remaining amount described in any of the preceding embodiments, after obtaining the remaining amount information, the controller 800 controls the sampling device 100 to sample and dispense the latex reagent in the reagent bottle 3 according to the remaining amount information and the identification information.

[0058] The controller 800 controls the sampling device 100 to sample and dispense the latex reagent in the reagent bottle 3 according to the remaining information and the identification information. This avoids the time waste and inaccurate test results caused by still sampling and dispensing the latex reagent in the reagent bottle 3 when there is not enough latex reagent.

[0059] In one embodiment, a plurality of reagent bottles 3 are placed in the latex container 300, and the latex reagents in the plurality of reagent bottles 3 are of the same type. The controller 800 determines whether the latex reagent in the current reagent bottle 3 has been used up based on the remaining information in the plurality of reagent bottles 3, and after the latex reagent in the reagent bottle 3 of the current container 30 has been used up, it controls the sampling device 100 to move to the reagent bottle 3 of the next container 30 to sample and dispense the latex reagent.

[0060] When multiple reagent bottles 3 contain the same type of latex reagent, if the latex reagent in the current compartment 30 is not used up, the controller 800 controls the sampling device 100 to continue sampling and dispensing latex reagent from the reagent bottle 3 in the current compartment 30. If the latex reagent in the current compartment 30 is used up, the controller 800 controls the sampling device 100 to move to the next compartment 30 to sample and dispense latex reagent. Understandably, when the multiple reagent bottles 3 contain the same type of latex reagent, the controller 800 controls the sampling device 100 to sequentially sample and dispense the latex reagent from the reagent bottles 3 according to a preset path. For example, the plurality of reagent bottles 3 are arranged in order from left to right. The controller 800 and the sampling device 100 start sampling and dispensing the latex reagent in the reagent bottle 3 from the leftmost compartment 30 until the latex reagent in the reagent bottle 3 is completely sampled. Then, the controller controls the sampling device 100 to start sampling and dispensing the latex reagent in the reagent bottle 3 from the second compartment 30 from the left until the latex reagent in the reagent bottle 3 is completely sampled.

[0061] In this embodiment, the controller 800 moves to the next reagent bottle 3 in the next compartment 30 only after the latex reagent in the reagent bottle 3 in the current compartment 30 has been used up, which makes it convenient to replace the used reagent bottle 3.

[0062] In one embodiment, when the controller 800 determines, based on the remaining amount information, that the latex reagent in the reagent bottle 3 is less than a preset remaining amount, it issues a prompt message.

[0063] The prompt information can be, but is not limited to, text, sound, light signals, etc. When the controller 800 determines that the latex reagent is less than a preset reserve based on the remaining amount, it issues a prompt information to remind the user of the sample analyzer 1 to promptly replace the reagent bottle 3. Understandably, the controller 800 can also issue different prompt information based on the type of reagent in the reagent bottle 3, as indicated by the identification information. For example, the latex reagent in reagent bottle 3 in compartment 30a is the latex reagent required for CRP testing, while the latex reagent in compartment 30b is the latex reagent required for SAA testing. When the remaining latex reagent in reagent bottle 3 in compartment 30a is less than a preset reserve a, prompt information a is issued; when the remaining latex reagent in compartment 30b is less than a preset reserve b, prompt information b is issued. Prompt information a and prompt information b are different so that the user of the sample analyzer 1 can distinguish which type of latex reagent in which compartment 30 needs to be replaced. Furthermore, due to the different types of latex reagents, the amount of latex reagent required for a single test varies. Therefore, the preset margin can differ for different latex reagents. In other words, preset margin a and preset margin b can be different.

[0064] This application also provides a specific protein detection method. The specific protein detection method of this application will be described below using the sample analyzer 1 described above. The specific protein detection method of this application can be performed by the sample analyzer 1 described above, and the sample analyzer 1 described above can perform the specific protein detection method of this application. Please refer to the accompanying documentation. Figure 9 and Figure 10 , Figure 9 A flowchart illustrating a specific protein detection method provided in one embodiment of this application; Figure 10 This diagram illustrates the locations of the reaction chamber, blood sample collection point, and latex chamber used in a specific protein detection method provided in one embodiment of this application. The specific protein detection method is applied to sample analyzer 1 and includes steps S110, S120, S130, S140, and S150. Detailed descriptions of steps S110, S120, S130, S140, and S150 are provided below.

[0065] S110, the sampling device 100 absorbs the blood sample from the sampling position and dispenses the blood sample into the reaction pool 500.

[0066] S120, the hemolytic agent supply device supplies the hemolytic agent required for the test to the reaction cell 500.

[0067] S130, the controller 800 controls the sampling device 100 to draw latex reagent from the reagent bottle 3 and discharge it into the reaction tank 500 according to the identification information of the information reading device 400, wherein the identification information includes at least the type of reagent in the reagent bottle 3.

[0068] S140, the reaction cell 500 receives the blood sample to be tested, latex reagent, and hemolysis reagent provided by the hemolysis reagent providing device 200 from the sampling device 100 to form a mixed sample required for testing. The reaction cell 500, the sampling position 50 where the blood sample is located, and the latex compartment 300 where the reagent bottle 3 is located are arranged on a straight line.

[0069] S150, the detection device 600 detects the mixed sample to obtain the specific protein concentration of the blood sample.

[0070] The sampling device 100 includes a sampling needle 140 and a motion drive mechanism 130 for driving the sampling needle 140. (See also...) Figure 11 , Figure 11 This is a schematic diagram of a sampling device provided according to an embodiment of this application. The sampling device 100 includes a device body 110, a mounting part 120, a drive mechanism 130, and a sampling needle 140. The mounting part 120 is disposed on the device body 110 and is used to mount the sampling needle 140. The mounting part 120 is also used to move relative to the device body 110 under the drive of the drive mechanism 130, thereby driving the sampling needle 140 to move. Specifically, the drive mechanism 130 is electrically connected to the controller 800 and is used to receive control signals issued by the controller 800 and move under the control of the control signals.

[0071] In this embodiment, the reaction tank 500, the sampling position where the blood sample is located, and the latex container 300 where the reagent bottle 3 is located are arranged on the same straight line. This allows the sampling device 100 to draw blood from the blood sampling position and then dispense the blood sample into the reaction tank 500 along a straight line. Given a constant speed of movement of the sampling needle 140, the time taken for the sampling device 100 to dispense the blood sample into the reaction tank 500 after drawing blood from the blood sampling position is minimized. Similarly, arranging the latex container 300 where the reagent bottle 3 is located, the reaction tank 500, and the sampling position where the blood sample is located on the same straight line also minimizes the time taken from drawing the latex reagent to dispensing the latex reagent into the reaction tank 500.

[0072] In one embodiment, the controller 800 controls the sampling device 100 to move along a preset straight line to the latex chamber 300 where the reagent bottle 3 is located; and the controller 800 controls the sampling device 100 to dispense the blood sample into the reaction pool 500 along the preset straight line.

[0073] The following describes the principle of the detection device 600 detecting the mixed sample when the specific protein is CRP. The reaction cell 500 includes a detection area made of a light-transmitting material, and the detection device 600 is correspondingly arranged with respect to the detection area. Since the reaction cell 500 includes a detection area made of a light-transmitting material, the detection area allows detection light to pass through; this detection area can also be called an optical area. When the specific protein is CRP, the wavelength of the detection light can be between 600 nm and 2400 nm. The detection device 600 can determine the concentration of the specific protein in the sample based on whether the detection light is absorbed or scattered by the reagent when it passes through the detection area and irradiates the sample; this method is also called turbidimetry.

[0074] In one embodiment, S130, the controller 800 controls the sampling device 100 to draw latex reagent from the reagent bottle 3 and dispense it into the reaction tank 500 according to the identification information of the information reading device 400. Specifically, the controller 800 controls the sampling device 100 to draw latex reagent from the reagent bottle 3 and dispense it into the reaction tank 500 according to the detection items of the sample analyzer 1 and the identification information.

[0075] In one embodiment, the specific protein detection method further includes: S30, where the controller 800 acquires information on the remaining amount of latex reagent in the reagent bottle 3. In one embodiment, S30 may be performed before or simultaneously with S130.

[0076] The controller 800 acquires the remaining amount of latex reagent in the reagent bottle 3 and adopts a corresponding control strategy based on the remaining amount information. The specific method by which the controller 800 acquires the remaining amount of latex reagent in the reagent bottle 3, and the corresponding control strategy adopted based on the remaining amount information, will be described in detail later.

[0077] In one embodiment, the identification information also includes the remaining amount of latex reagent in the reagent bottle 3. S30, the controller 800 also obtains the remaining amount information of latex reagent in the reagent bottle 3, specifically including: S31, the controller 800 controls the information reading device 400 to read the label on the reagent bottle 3 to obtain the remaining amount information.

[0078] Understandably, the identification information includes not only the type of latex reagent in the reagent bottle 3, but also the remaining amount of latex reagent in the reagent bottle 3. In other words, the label's identification information carries the type of latex reagent and the remaining amount of latex reagent, and the information reading device 400 can obtain the remaining amount information by reading the label in the reagent bottle 3.

[0079] Furthermore, the specific protein detection method further includes: S32, after the sampling device 100 samples the latex reagent in the reagent bottle 3, the controller 800 controls the information reading device 400 to write new remaining information to the label based on the remaining information before sampling and the amount of latex reagent consumed during sampling, so as to update the remaining information in the identification information.

[0080] Specifically, the specific protein detection method includes S31 and S32. In one embodiment, S31 is located before S130, and S32 is located after S130. Please refer to [link / reference needed]. Figure 12 , Figure 12 This is a flowchart illustrating a specific protein detection method according to another embodiment of this application. It is understood that the specific protein detection method including S31 and S32 can also be located in other positions, as long as the specific protein detection method includes S31 and S32.

[0081] By updating the remaining information in the identification information, the remaining information in the identification is made consistent with the actual remaining amount of latex reagent in the reagent bottle 3, so that the controller 800 can control the sampling device 100 to draw latex reagent from the corresponding reagent bottle 3 according to the read remaining information.

[0082] In one embodiment, S30, the controller 800 further acquires the remaining amount information of latex reagent in reagent bottle 3, specifically including: S33, the controller 800 determines the remaining amount information of latex reagent in reagent bottle 3 based on the number of times the latex reagent in reagent bottle 3 has been sampled and the preset number of times the latex reagent in reagent bottle 3 can be sampled.

[0083] Specifically, the latex reagent in reagent bottle 3 can be used a preset number of times. If the number of times the latex reagent has been sampled is less than the preset number, then the remaining amount of latex reagent is not zero, and the latex reagent in reagent bottle 3 can be sampled again. If the number of times the latex reagent has been sampled is equal to the preset number, then the remaining amount of latex reagent in reagent bottle 3 is zero, and it cannot be sampled again. For example, if the preset number of times the latex reagent in reagent bottle 3 can be sampled is 100, and if the latex reagent in reagent bottle 3 has been sampled 35 times, then 100-35=65, and the latex reagent in reagent bottle 3 can be used again for 65 times. In this embodiment, the controller 800 records and updates the number of samplings each time the latex reagent is sampled.

[0084] In one embodiment, the controller 800 controls the sampling device 100 to draw latex reagent from the reagent bottle 3 and dispense it into the reaction tank 500 based on the identification information of the information reading device 400. Specifically, the controller 800 controls the sampling device 100 to sample and dispense the latex reagent in the reagent bottle 3 based on the remaining amount information and the identification information.

[0085] The controller 800 controls the sampling device 100 to sample and dispense the latex reagent in the reagent bottle 3 based on the remaining amount information and the identification information. This avoids the time wastage and inaccurate test results caused by continuing to sample and dispense the latex reagent in the reagent bottle 3 even when the latex reagent in the reagent bottle 3 is insufficient.

[0086] In one embodiment, when the latex reagents in multiple reagent bottles 3 are of the same type, the specific protein detection method includes:

[0087] S40. The controller 800 determines whether the latex reagent in the current reagent bottle 3 has been used up based on the remaining information in the plurality of reagent bottles 3. After the latex reagent in the reagent bottle 3 of the current compartment 30 has been used up, the controller controls the sampling device 100 to move to the reagent bottle 3 of the next compartment 30 to sample and dispense the latex reagent.

[0088] When multiple reagent bottles 3 contain the same type of latex reagent, if the latex reagent in the current compartment 30 is not used up, the controller 800 controls the sampling device 100 to continue sampling and dispensing latex reagent from the reagent bottle 3 in the current compartment 30. If the latex reagent in the current compartment 30 is used up, the controller 800 controls the sampling device 100 to move to the next compartment 30 to sample and dispense latex reagent. Understandably, when the multiple reagent bottles 3 contain the same type of latex reagent, the controller 800 controls the sampling device 100 to sequentially sample and dispense the latex reagent from the reagent bottles 3 according to a preset path. For example, the plurality of reagent bottles 3 are arranged in order from left to right. The controller 800 and the sampling device 100 start sampling and dispensing the latex reagent in the reagent bottle 3 from the leftmost compartment 30 until the latex reagent in the reagent bottle 3 is completely sampled. Then, the controller controls the sampling device 100 to start sampling and dispensing the latex reagent in the reagent bottle 3 from the second compartment 30 from the left until the latex reagent in the reagent bottle 3 is completely sampled.

[0089] In this embodiment, the controller 800 moves to the next reagent bottle 3 in the next compartment 30 only after the latex reagent in the reagent bottle 3 in the current compartment 30 has been used up, which makes it convenient to replace the used reagent bottle 3.

[0090] In one embodiment, the specific protein detection method includes:

[0091] S50. When the controller 800 determines, based on the remaining amount information, that the latex reagent in the reagent bottle 3 is less than the preset remaining amount, it issues a prompt message.

[0092] The prompt information can be, but is not limited to, text, sound, light signals, etc. When the controller 800 determines that the latex reagent is less than a preset reserve based on the remaining amount, it issues a prompt information to remind the user of the sample analyzer 1 to promptly replace the reagent bottle 3. Understandably, the controller 800 can also issue different prompt information based on the type of reagent in the reagent bottle 3, as indicated by the identification information. For example, the latex reagent in reagent bottle 3 in compartment 30a is the latex reagent required for CRP testing, while the latex reagent in compartment 30b is the latex reagent required for SAA testing. When the remaining latex reagent in reagent bottle 3 in compartment 30a is less than a preset reserve a, prompt information a is issued; when the remaining latex reagent in compartment 30b is less than a preset reserve b, prompt information b is issued. Prompt information a and prompt information b are different so that the user of the sample analyzer 1 can distinguish which type of latex reagent in which compartment 30 needs to be replaced. Furthermore, due to the different types of latex reagents, the amount of latex reagent required for a single test varies. Therefore, the preset margin can differ for different latex reagents. In other words, preset margin a and preset margin b can be different.

[0093] The embodiments of this application have been described in detail above. Specific examples have been used to illustrate the principles and implementation methods of this application. The above description of the embodiments is only for the purpose of helping to understand the method and core ideas of this application. At the same time, for those skilled in the art, there will be changes in the specific implementation methods and application scope based on the ideas of this application. Therefore, the content of this specification should not be construed as a limitation of this application.

Claims

1. A sample analyzer, characterized in that, The sample analyzer includes: A sampling device for collecting blood samples and dispensing the blood samples, the sampling device including a sampling needle and a drive mechanism for driving the movement of the sampling needle; A latex container is used to hold a reagent bottle containing latex reagents. The reagent bottle has a label with identification information, wherein the identification information includes at least the type of reagent in the reagent bottle. Information reading device, the information reading device being used to read the label on the reagent bottle to obtain identification information; The latex container has N compartments, where N ≥ 2 and N is a positive integer. The information reading device includes N sub-reading devices, each of which corresponds to one of the N compartments. Each sub-reading device is used to read the identification information carried on the label of the reagent bottle placed in the corresponding compartment. Each compartment is used to place one reagent bottle. The reagents in the reagent bottles placed in each compartment can be the same or different. The controller controls the sampling device to sample and dispense latex reagent in the reagent bottle according to the detection item and the identification information. This includes determining the compartment containing the reagent required for the detection item from the N compartments based on the detection item and the identification information obtained by the N sub-reading devices, and controlling the driving mechanism to drive the sampling needle to move to the reagent bottle in the latex compartment to sample and dispense the latex reagent. The reaction chamber receives the blood sample and latex reagent to form the mixed sample required for the test; and A detection device is used to detect the mixed sample to obtain the specific protein concentration of the blood sample.

2. The sample analyzer as described in claim 1, characterized in that, The controller is also used to obtain information on the remaining amount of latex reagent in the reagent bottle.

3. The sample analyzer as described in claim 2, characterized in that, The identification information also includes the remaining amount of latex reagent in the reagent bottle, and the information reading device reads the label on the reagent bottle to obtain the remaining amount information.

4. The sample analyzer as described in claim 3, characterized in that, After the sampling device samples the latex reagent in the reagent bottle, the information reading device is also used to write new remaining information to the label based on the remaining information before sampling and the amount of latex reagent consumed during sampling, so as to update the remaining information in the identification information.

5. The sample analyzer as described in claim 2, characterized in that, The controller is also used to determine the remaining amount of latex reagent in the reagent bottle based on the number of times the latex reagent in the reagent bottle has been sampled and a preset number of times the latex reagent in the reagent bottle can be sampled.

6. The sample analyzer as described in any one of claims 2-5, characterized in that, The controller controls the sampling device to sample and dispense the latex reagent in the reagent bottle based on the remaining amount information and the identification information.

7. The sample analyzer as described in claim 6, characterized in that, The latex compartment contains multiple reagent bottles, all of which contain the same type of latex reagent. The controller determines whether the latex reagent in the current reagent bottle has been used up based on the remaining amount information in the multiple reagent bottles. After the latex reagent in the reagent bottle in the current compartment is used up, the controller moves the sampling device to the reagent bottle in the next compartment to sample and dispense the latex reagent.

8. The sample analyzer as described in claim 2, characterized in that, When the controller determines, based on the remaining amount information, that the latex reagent in the reagent bottle is less than the preset remaining amount, it issues a prompt message.

9. The sample analyzer as described in claim 1, characterized in that, The latex compartment includes a bracket and N-1 first partitions. The N-1 first partitions are connected to the bracket and are made of electromagnetic wave shielding material. The N-1 first partitions are spaced apart, and the bracket and the N-1 first partitions cooperate to form N compartments.

10. The sample analyzer as described in claim 9, characterized in that, The latex container includes N trays, each tray is used to carry a sub-reading device, and each tray carries one sub-reading device, with different trays carrying different sub-reading devices.

11. The sample analyzer as described in claim 1, characterized in that, It also includes a hemolysis reagent supply device for supplying hemolysis reagents required for testing the detection items to the reaction cell. The reaction cell receives the hemolysis reagents provided by the hemolysis reagent supply device and mixes the hemolysis reagents with the blood sample to be tested and latex reagents to form a mixed sample required for testing.

12. A method for detecting a specific protein, characterized in that, The specific protein detection method is applied to the sample analyzer according to any one of claims 1 to 11, wherein the specific protein detection method comprises: The sampling device draws blood samples from the sampling position and dispenses the blood samples into the reaction tank; The controller controls the sampling device to draw latex reagent from the reagent bottle and dispense it into the reaction tank based on the identification information of the information reading device. The identification information includes at least the type of reagent in the reagent bottle. The reaction chamber receives the blood sample and latex reagent to form the mixed sample required for the test, wherein the reaction chamber, the sampling position of the blood sample, and the latex chamber containing the reagent bottle are arranged in a straight line; and The detection device tests the mixed sample to obtain the specific protein concentration of the blood sample.

13. The method for detecting a specific protein as described in claim 12, characterized in that, The controller, based on the identification information of the information reading device, controls the sampling device to draw latex reagent from the reagent bottle and dispense it into the reaction tank, specifically including: The controller controls the sampling device to draw latex reagent from the reagent bottle and dispense it into the reaction tank according to the detection items of the sample analyzer and the identification information.

14. The method for detecting a specific protein as described in claim 12, characterized in that, The controller also acquires information about the remaining amount of latex reagent in the reagent bottle.

15. The method for detecting a specific protein as described in claim 14, characterized in that, The identification information also includes the remaining amount of latex reagent in the reagent bottle. The controller also acquires information on the remaining amount of latex reagent in the reagent bottle, specifically including: The controller controls the information reading device to read the label on the reagent bottle to obtain the remaining quantity information.

16. The method for detecting a specific protein as described in claim 15, characterized in that, The specific protein detection method also includes: After the sampling device samples the latex reagent in the reagent bottle, the controller controls the information reading device to write new remaining information to the label based on the remaining information before sampling and the amount of latex reagent consumed during sampling, so as to update the remaining information in the identification information.

17. The method for detecting a specific protein as described in claim 15, characterized in that, The controller also acquires information on the remaining amount of latex reagent in the reagent bottle, specifically including: The controller determines the remaining amount of latex reagent in the reagent bottle based on the number of times the latex reagent in the reagent bottle has been sampled and a preset number of times the latex reagent in the reagent bottle can be sampled.

18. The method for detecting a specific protein as described in any one of claims 14-17, characterized in that, The controller, based on the identification information from the information reading device, controls the sampling device to draw latex reagent from the reagent bottle and dispense it into the reaction tank, specifically including: The controller controls the sampling device to sample and dispense the latex reagent in the reagent bottle based on the remaining amount information and the identification information.

19. The method for detecting a specific protein as described in claim 18, characterized in that, When multiple reagent bottles contain the same type of latex reagent, the specific protein detection method includes: The controller determines whether the latex reagent in the current reagent bottle has been used up based on the remaining information in the multiple reagent bottles. After the latex reagent in the reagent bottle in the current compartment is used up, the controller controls the sampling device to move to the reagent bottle in the next compartment to sample and dispense the latex reagent.

20. The method for detecting a specific protein as described in claim 14, characterized in that, The specific protein detection method includes: When the controller determines, based on the remaining amount information, that the latex reagent in the reagent bottle is less than the preset remaining amount, it issues a prompt message.

21. The method for detecting a specific protein as described in claim 12, characterized in that, The controller controls the sampling device to move along a preset straight line to the latex chamber where the reagent bottle is located; and the controller controls the sampling device to dispense the blood sample into the reaction tank along the preset straight line.

22. The method for detecting a specific protein as described in claim 12, characterized in that, It also includes the step of: the hemolysin providing device provides the hemolysin required for the test item to the reaction cell, so as to mix with the blood sample to be tested and the latex reagent in the reaction cell to form a mixed sample.

Images