Separation of biological and non-biological components using magnetic levitation

By combining a magnetic levitation system with smartphone imaging, the challenge of separating and sorting heterogeneous cell populations in microfluidic environments has been solved, enabling portable and low-cost cell separation and disease diagnosis, suitable for rapid diagnosis and monitoring in home and clinical settings.

CN113960303BActive Publication Date: 2025-10-24THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
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Patent Information

Application Number
CN202111453955.9
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Priority Date
2015-10-02
Filing Date
2016-09-30
Publication Date
2025-10-24
Estimated Expiration
2036-09-30

AI Technical Summary

Technical Problem

Existing technologies struggle to efficiently, portablely, and cost-effectively separate and sort heterogeneous cell populations in microfluidic environments, particularly for cell counting and disease diagnosis without the use of labels. Furthermore, traditional methods are complex and unsuitable for microscopy.

Method used

A magnetically levitated diagnostic system is employed, which uses magnetic gradients to separate different cells and combines them with smartphone imaging. Cells are separated in microcapillary or microfluidic channels using magnets, enabling portable and rapid disease diagnosis and monitoring.

Benefits of technology

It enables the separation and counting of white and red blood cells in home and clinical settings, supports high-throughput separation of circulating tumor cells, is suitable for three-dimensional cell culture and magnetically suspended cells, and provides a portable, low-cost disease diagnosis and monitoring platform.

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Abstract

Systems and methods are provided for suspending populations of components, cells, or other such units in a microfluidic environment with one or more magnets. These systems and methods can be used, for example, for the separation and sorting of heterogeneous unit populations from one another, to form multi-unit collections while the units are suspended, and to assess samples in real time at the point of care. These systems and methods can also utilize a frame so that imaging devices, such as smartphones, can capture units in real time as they are manipulated within the system.
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Citation Information

Patent Citations

  • System and method for cell levitation and monitoring

    CN106471370A

  • Sorting biological and non-biological moieties using magnetic levitation

    CN108369224A

  • Density-based methods for separation of materials, monitoring of solid supported reactions and measuring densities of small liquid volumes and solids

    US20100285606A1

  • System and method for cell levitation and monitoring

    WO2015130913A1