Air purification slow-release gel composition, air purification box and preparation method

Abstract

The present application relates to air purification technical field, especially to a kind of air purification slow-release gel combination, air purification box and preparation method.The air purification slow-release gel combination includes chlorine dioxide slow-release gel and traditional Chinese medicine slow-release gel, wherein chlorine dioxide slow-release gel includes the following weight fraction components: 2.5-12% (w / v) oxalic acid aqueous solution 80-95 parts, sodium chlorite 2-8 parts and polypropylene 0.08-0.15 parts, traditional Chinese medicine slow-release gel includes traditional Chinese medicine extract and traditional Chinese medicine slow-release skeleton material.The air purification slow-release gel combination has effective sterilization effect, and can also oxidize and reduce with various organic and inorganic matters in air to achieve the purpose of decomposing odor and purifying air, and chlorine dioxide and active ingredients in traditional Chinese medicine extract are slowly released, which can achieve the effect of long-time air purification.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of air purification technology, in particular to an air purification slow-release gel combination, an air purification box and a preparation method. BACKGROUND

[0002] With the aggravation of atmospheric environment pollution and the spread of epidemic viruses, the air is filled with various toxic volatile gases, dust suspended particles and microorganisms such as bacteria and viruses, which pose a great threat to human health. For people living in cities with relatively serious air pollution, most of the time is spent indoors, and indoor air disinfection and purification can improve people's quality of life to a certain extent, so it is increasingly valued.

[0003] Traditional air disinfection and purification technologies mainly include activated carbon adsorption, active oxygen technology, negative oxygen ion purification technology, and electrostatic dust collection technology. Among them, activated carbon adsorption uses micropores for physical and chemical adsorption, but only temporary adsorption, and as the temperature rises and the air flows, the adsorbed pollutants may be released; active oxygen technology uses ozone to inactivate bacteria in the air, which is complete and fast, but excessive ozone is harmful to human health, causing symptoms such as sore throat, chest tightness, and cough, and may induce bronchitis, emphysema, and nerve poisoning; negative oxygen ion purification technology uses negative oxygen ions to neutralize positively charged air dust and make it settle, thereby purifying the air, but negative oxygen ions have a very short lifespan in the air and need to be continuously released; electrostatic dust collection technology uses high-voltage static electricity to adsorb particulate pollutants in the air, such as dust, soot, pollen, cigarette smoke, and kitchen fumes, but only has an effect on large particle gases such as particulate matter, and can easily produce ozone.

[0004] Therefore, traditional air purification technologies have limitations and cannot simultaneously achieve safety, non-toxicity, significant purification effect, and multiple functions.

[0005] Chlorine dioxide is safe, non-toxic, highly efficient, and broad-spectrum, and can be used for air disinfection and purification. However, chlorine dioxide is active, has a short release period, and is not easy to store, which restricts its use as an active substance for air purification. SUMMARY

[0006] In view of the problems that current air disinfection and purification products cannot simultaneously achieve safety, non-toxicity, significant purification effect, and multiple functions, and chlorine dioxide has a short release period and is not easy to store, the present application provides an air purification slow-release gel combination, an air purification box and a preparation method.

[0007] To achieve the above-mentioned application purposes, the embodiments of the present application adopt the following technical solutions:

[0008] In one aspect, the present application provides an air purification sustained-release gel composition, comprising a chlorine dioxide sustained-release gel and a traditional Chinese medicine sustained-release gel, wherein the chlorine dioxide sustained-release gel comprises the following components in parts by weight: 2.5-12% (w / v) oxalic acid aqueous solution 80-95 parts, sodium chlorite 2-8 parts and polypropylene 0.08-0.15 parts; the traditional Chinese medicine sustained-release gel comprises traditional Chinese medicine extract 0.4-0.8 parts and traditional Chinese medicine sustained-release matrix material; and the particle size of the polypropylene is <0.18 μm.

[0009] The present application utilizes the reaction of oxalic acid and sodium chlorite to produce chlorine dioxide, which can volatilize into the air to play an effective sterilization effect, and can also undergo redox reactions with various organic and inorganic substances in the air to achieve the purposes of decomposing odors and purifying air. The polypropylene can form a gel with the oxalic acid aqueous solution and the sodium chlorite, and can regulate the release rate of the chlorine dioxide and prolong its release period. The traditional Chinese medicine sustained-release matrix material is used to regulate the release rate of the traditional Chinese medicine extract, so that the chlorine dioxide and the traditional Chinese medicine extract can be released slowly together to achieve the effect of long-term air purification, and are safe and non-toxic, have a significant purification effect, and can help reduce the incidence of epidemic diseases transmitted through the air. In addition, the present application also has the unique fragrance of traditional Chinese medicine, and can be used in various scenes such as living rooms, offices and cars.

[0010] The amount of the traditional Chinese medicine sustained-release matrix material can be selected by those skilled in the art according to conventional experiments, and a gel can be formed with the traditional Chinese medicine extract.

[0011] Preferably, the chlorine dioxide sustained-release gel comprises the following components in parts by weight: 2.5-8% (w / v) oxalic acid 80-95 parts, sodium chlorite 2-6 parts and polypropylene 0.08-0.12 parts.

[0012] Preferably, the chlorine dioxide sustained-release gel comprises the following components in parts by weight: 4-6.5% (w / v) oxalic acid 80-95 parts, sodium chlorite 3-5 parts and polypropylene 0.08-0.1 parts. The chlorine dioxide sustained-release gel with the above-mentioned ratio can release chlorine dioxide for a longer time.

[0013] Preferably, the traditional Chinese medicine extract comprises forsythia suspensa extract and honeysuckle extract, and the mass ratio of the forsythia suspensa extract to the honeysuckle extract is 0.5-2:1.

[0014] The forsythia extract has antibacterial and antiviral effects, and can inhibit bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, Candida albicans, Shigella boydii and Saccharomyces cerevisiae, and can also effectively inhibit fungi such as Penicillium chrysogenum and Aspergillus niger. The forsythia extract can also improve the odor generated after the decomposition of chlorine dioxide, and is helpful to keep the air fresh. The honeysuckle extract has certain inhibitory effect on various pathogenic bacteria such as Staphylococcus aureus, hemolytic streptococcus, Escherichia coli, dysentery bacillus, Vibrio cholerae, Salmonella typhi, paratyphi bacillus, and also has inhibitory and killing effects on Streptococcus pneumoniae, meningococcus, Pseudomonas aeruginosa, Mycobacterium tuberculosis, Shigella dysenteriae and Streptococcus mutans, and can inhibit influenza virus, orphan virus, herpes virus and leptospira.

[0015] The forsythia extract and the honeysuckle extract are used in the air purification slow-release gel combination, which can more effectively inhibit the reproduction of harmful microorganisms, purify the air, and also can reduce the incidence of respiratory diseases such as influenza in the population in the space where the product is used, so that the air purification slow-release gel combination has multiple effects.

[0016] Optionally, the preparation method of the forsythia extract is as follows: the forsythia is extracted by heating reflux with 45-65% v / v ethanol aqueous solution whose pH is adjusted to 8-8.5 by sodium hydroxide; after the extraction is completed, the filtrate is filtered, concentrated, and then eluted with 85-95% v / v ethanol aqueous solution, and then eluted with water, and the water elution fraction is collected and concentrated to 1.2-1.3 g / ml to obtain the forsythia extract; wherein the mass of the 45-65% v / v ethanol aqueous solution is 5-8 times the mass of the forsythia.

[0017] The preparation method of the honeysuckle extract is as follows: the honeysuckle is extracted by heating reflux with 55-60% v / v ethanol aqueous solution whose pH is adjusted to 8-8.5 by sodium hydroxide, and then the filter residue is extracted by heating reflux with 25-35% v / v ethanol aqueous solution, and then the filtrate is filtered, concentrated to 1.2-1.3 g / ml to obtain the honeysuckle extract.

[0018] The forsythia extract and the honeysuckle extract obtained by the above preparation method contain various volatile oils and water-soluble volatile components, which can further improve the sterilization and disinfection effect of the air purification slow-release gel combination, and more effectively improve the odor generated after the decomposition of chlorine dioxide. Compared with the traditional air disinfection and purification technologies such as activated carbon adsorption, ozone purification technology, negative oxygen ion technology and electrostatic dust collection technology, the air purification slow-release gel combination obtained by combining the forsythia extract and the honeysuckle extract with chlorine dioxide has remarkable bacteriostatic effect, is safe and non-toxic, and compared with the commercially available ordinary non-scented chlorine dioxide air purification gel, the use of the air purification slow-release gel combination is more comfortable, the scent is pleasant, and the fresh air effect is obvious.

[0019] The type of the polar macroporous adsorption resin used for preparing the forsythia extract solution is preferably XDA-1, XDA-8, LSA-7 or LSA-5B.

[0020] Alternatively, the traditional Chinese medicine sustained-release matrix material is polypropylene, such as YUHMA POLYPRO U050.

[0021] In a second aspect, the embodiments of the present application further provide a preparation method of the air purification sustained-release gel combination, which specifically comprises the following steps:

[0022] S1, soaking the traditional Chinese medicine sustained-release matrix material in the traditional Chinese medicine extract solution until saturated absorption, and then taking out to obtain the traditional Chinese medicine sustained-release gel;

[0023] S2, mixing the sodium chlorite and the polypropylene, and mixing with the aqueous oxalic acid solution before use to obtain the chlorine dioxide sustained-release gel;

[0024] S3, jointly releasing the gas from the traditional Chinese medicine sustained-release gel and the chlorine dioxide sustained-release gel through a gas releasing container.

[0025] The volatile components in the traditional Chinese medicine extract solution can be slowly released by using the traditional Chinese medicine sustained-release matrix material. The mixed sodium chlorite and polypropylene are mixed with the aqueous oxalic acid solution before use, and the polypropylene can form a gel in the aqueous oxalic acid solution, so that the chlorine dioxide generated by the reaction of sodium chlorite and oxalic acid is slowly released. The chlorine dioxide and the volatile components in the traditional Chinese medicine extract solution are slowly released together, which can achieve a long-lasting air purification effect, and the volatile components in the traditional Chinese medicine extract solution can also improve the odor of the released gas and mask the unpleasant odor generated by the decomposition of chlorine dioxide.

[0026] In a third aspect, the embodiments of the present application further provide an air purification box, which comprises a gas releasing box and the air purification sustained-release gel combination described above; the gas releasing box is composed of a solid storage part and a liquid storage part which are detachably connected, the solid storage part comprises a dry powder storage cavity for storing the sodium chlorite and polypropylene and a gel storage cavity for storing the traditional Chinese medicine sustained-release gel, and the bottom of the dry powder storage cavity is a film; the liquid storage part comprises a liquid storage cavity for storing the aqueous oxalic acid solution, a puncture part for puncturing the film at the bottom of the dry powder storage cavity, and a leakage hole for making the sodium chlorite and polypropylene leak into the liquid storage cavity; the top of the solid storage part is provided with a gas adjusting mechanism which can close the dry powder storage cavity and the gel storage cavity and adjust the release of gas in the dry powder storage cavity and the gel storage cavity.

[0027] The air purification box can isolate the sodium chlorite and the oxalic acid aqueous solution during the shelf life, avoid the reaction of the two in advance, and solve the problem that the chlorine dioxide is not easy to store; the puncture part pierces the film at the bottom of the dry powder storage cavity during use, so that the sodium chlorite and the polypropylene leak into the liquid storage cavity through the material leakage hole to mix with the oxalic acid aqueous solution to form a chlorine dioxide slow-release gel, the generated chlorine dioxide gas escapes through the material leakage hole, enters the dry powder storage cavity, and is then released into the air through the gas adjusting mechanism; the gas adjusting mechanism can avoid volatilization of the volatile components of the traditional Chinese medicine extract in the traditional Chinese medicine slow-release gel during the shelf life, and avoid leakage of the sodium chlorite and the polypropylene, and on the other hand, the amount of release of the chlorine dioxide gas and the volatile components of the traditional Chinese medicine extract in the traditional Chinese medicine slow-release gel can be adjusted as needed during use.

[0028] Preferably, the solid storage part and the liquid storage part are both cylindrical, and the solid storage part and the liquid storage part are connected in a threaded fit, so that the puncture part can pierce the film at the bottom of the dry powder storage cavity by rotating. BRIEF DESCRIPTION OF DRAWINGS

[0029] Figure 1 Figure 9 is a structural schematic diagram of a gas release box in Example 9 of the present application;

[0030] In the figure:

[0031] 1 solid storage part;

[0032] 11 dry powder storage cavity; 111 film;

[0033] 12 gel storage cavity;

[0034] 13 gas adjusting mechanism; 131 inner cover; 1311 inner vent hole; 132 outer cover; 1321 outer vent hole; 133 sealing layer;

[0035] 2 liquid storage part; 21 liquid storage cavity; 22 puncture part; 23 material leakage hole. DETAILED DESCRIPTION

[0036] In order to make the purpose, technical scheme and advantages of the present application more clear, the present application will be further described in detail below with specific examples. It should be understood that the specific examples described herein are only used to explain the present application, and are not used to limit the present application.

[0037] Unless otherwise specified, the experimental methods used in the following examples are conventional methods in the art.

[0038] The forsythia and honeysuckle used in the following examples all meet the relevant provisions of each medicinal material in the first part of Chinese Pharmacopoeia (2015 edition).

[0039] The polypropylene is used as the Chinese medicine sustained-release matrix material in the following examples, but in order to avoid confusion with the polypropylene in the chlorine dioxide sustained-release gel, the polypropylene in the Chinese medicine sustained-release gel is still referred to as the Chinese medicine sustained-release matrix material in each example.

[0040] The raw materials and reagents used in the following examples were obtained from commercial sources unless otherwise specified.

[0041] Example 1

[0042] The air purification sustained-release gel combination provided by the example of the present application comprises a chlorine dioxide sustained-release gel and a Chinese medicine sustained-release gel, wherein the chlorine dioxide sustained-release gel comprises the following components in parts by weight: 85 parts of 7% (w / v) aqueous oxalic acid, 4 parts of sodium chlorite and 0.09 parts of polypropylene; the Chinese medicine sustained-release gel comprises 0.6 parts of a Chinese medicine extract and a Chinese medicine sustained-release matrix material, and the Chinese medicine extract is composed of forsythia suspensa extract and honeysuckle extract in a mass ratio of 1:1.

[0043] The forsythia suspensa extract is prepared by heating reflux extraction of forsythia suspensa with 55% v / v aqueous ethanol solution adjusted to pH 8.2 with sodium hydroxide, and the mass of the 55% v / v aqueous ethanol solution is 7 times the mass of forsythia suspensa; after extraction, the obtained filtrate is filtered, concentrated, and eluted with 90% v / v aqueous ethanol solution, and then eluted with water; the water elution flow fraction is collected and concentrated to 1.25 g / ml.

[0044] The honeysuckle extract is prepared by heating reflux extraction of honeysuckle with 57% v / v aqueous ethanol solution adjusted to pH 8.2 with sodium hydroxide, and the mass of the 57% v / v aqueous ethanol solution is 7 times the mass of honeysuckle; the obtained filter residue is heated and refluxed with 30% v / v aqueous ethanol solution, and the mass of the 30% v / v aqueous ethanol solution is 7 times the mass of honeysuckle; the filtrate obtained by the two extractions is combined and concentrated to 1.25 g / ml.

[0045] The preparation method of the air purification sustained-release gel combination is as follows:

[0046] S1, soaking the Chinese medicine sustained-release matrix material in the Chinese medicine extract until saturation, and then taking it out to obtain the Chinese medicine sustained-release gel;

[0047] S2, mixing sodium chlorite and polypropylene, and mixing with the aqueous oxalic acid solution just before use to obtain the chlorine dioxide sustained-release gel;

[0048] S3, releasing the gas from the Chinese medicine sustained-release gel and the chlorine dioxide sustained-release gel through a gas release container.

[0049] Example 2

[0050] The air purification sustained-release gel combination provided by the embodiment of the present application comprises a chlorine dioxide sustained-release gel and a traditional Chinese medicine sustained-release gel, wherein the chlorine dioxide sustained-release gel comprises the following components in parts by weight: 85 parts of 7% (w / v) oxalic acid aqueous solution, 4 parts of sodium chlorite and 0.09 part of polypropylene; the traditional Chinese medicine sustained-release gel comprises 0.6 parts of a traditional Chinese medicine extract and a traditional Chinese medicine sustained-release skeleton material, and the traditional Chinese medicine extract is composed of forsythia suspensa extract and honeysuckle extract in a mass ratio of 0.5:1.

[0051] The forsythia suspensa extract is prepared by heating and refluxing forsythia suspensa with 45% v / v ethanol aqueous solution whose mass is 5 times that of the forsythia suspensa, and the pH of the 45% v / v ethanol aqueous solution is adjusted to 8 by sodium hydroxide; after the extraction is completed, the obtained filtrate is filtered, concentrated, and then subjected to XDA-8 macroporous adsorption resin, eluted with 85% v / v ethanol aqueous solution, and then eluted with water; the water elution flow fraction is collected and concentrated to 1.2 g / ml.

[0052] The honeysuckle extract is prepared by heating and refluxing honeysuckle with 55% v / v ethanol aqueous solution whose mass is 6 times that of the honeysuckle, and the pH of the 55% v / v ethanol aqueous solution is adjusted to 8 by sodium hydroxide; the obtained filter residue is heated and refluxed with 25% v / v ethanol aqueous solution whose mass is 6 times that of the honeysuckle; the filtrate obtained by the two times of extraction is combined and concentrated to 1.2 g / ml.

[0053] The preparation method of the air purification sustained-release gel combination is the same as that in Embodiment 1.

[0054] Embodiment 3

[0055] The air purification sustained-release gel combination provided by the embodiment of the present application comprises a chlorine dioxide sustained-release gel and a traditional Chinese medicine sustained-release gel, wherein the chlorine dioxide sustained-release gel comprises the following components in parts by weight: 85 parts of 7% (w / v) oxalic acid aqueous solution, 4 parts of sodium chlorite and 0.09 part of polypropylene; the traditional Chinese medicine sustained-release gel comprises 0.6 parts of a traditional Chinese medicine extract and a traditional Chinese medicine sustained-release skeleton material, and the traditional Chinese medicine extract is composed of forsythia suspensa extract and honeysuckle extract in a mass ratio of 2:1.

[0056] The forsythia suspensa extract is prepared by heating and refluxing forsythia suspensa with 65% v / v ethanol aqueous solution whose mass is 8 times that of the forsythia suspensa, and the pH of the 65% v / v ethanol aqueous solution is adjusted to 8.5 by sodium hydroxide; after the extraction is completed, the obtained filtrate is filtered, concentrated, and then subjected to LSA-7 macroporous adsorption resin, eluted with 95% v / v ethanol aqueous solution, and then eluted with water; the water elution flow fraction is collected and concentrated to 1.3 g / ml.

[0057] The preparation method of the honeysuckle extract solution is as follows: the honeysuckle is extracted by heating reflux with 60% v / v ethanol aqueous solution whose pH is adjusted to 8.5 by sodium hydroxide, and the mass of the 60% v / v ethanol aqueous solution is 8 times the mass of the honeysuckle; the obtained residue is extracted by heating reflux with 35% v / v ethanol aqueous solution, and the mass of the 35% v / v ethanol aqueous solution is 8 times the mass of the honeysuckle; the filtrates obtained by the two times of extraction are combined and concentrated to 1.3 g / ml, and the honeysuckle extract solution is obtained.

[0058] The preparation method of the air purification sustained-release gel combination is the same as that in Example 1.

[0059] Example 4

[0060] The embodiment of the present application provides an air purification sustained-release gel combination, which comprises a chlorine dioxide sustained-release gel and a traditional Chinese medicine sustained-release gel, wherein the chlorine dioxide sustained-release gel comprises the following components in parts by weight: 4% (w / v) oxalic acid aqueous solution 80 parts, sodium chlorite 3 parts and polypropylene 0.08 part; the traditional Chinese medicine sustained-release gel comprises traditional Chinese medicine extract solution 0.5 part and traditional Chinese medicine sustained-release skeleton material, and the traditional Chinese medicine extract solution is composed of forsythia suspensa extract solution and honeysuckle extract solution in a mass ratio of 0.7:1.

[0061] The preparation method of the forsythia suspensa extract solution, the honeysuckle extract solution and the air purification sustained-release gel combination is the same as that in Example 1.

[0062] Example 5

[0063] The embodiment of the present application provides an air purification sustained-release gel combination, which comprises a chlorine dioxide sustained-release gel and a traditional Chinese medicine sustained-release gel, wherein the chlorine dioxide sustained-release gel comprises the following components in parts by weight: 6.5% (w / v) oxalic acid aqueous solution 95 parts, sodium chlorite 5 parts and polypropylene 0.1 part; the traditional Chinese medicine sustained-release gel comprises traditional Chinese medicine extract solution 0.7 part and traditional Chinese medicine sustained-release skeleton material, and the traditional Chinese medicine extract solution is composed of forsythia suspensa extract solution and honeysuckle extract solution in a mass ratio of 1.5:1.

[0064] The preparation method of the forsythia suspensa extract solution and the honeysuckle extract solution and the air purification sustained-release gel combination is the same as that in Example 1.

[0065] Example 6

[0066] The embodiment of the present application provides an air purification sustained-release gel combination, which comprises a chlorine dioxide sustained-release gel and a traditional Chinese medicine sustained-release gel, wherein the chlorine dioxide sustained-release gel comprises the following components in parts by weight: 2.5% (w / v) oxalic acid aqueous solution 80 parts, sodium chlorite 2 parts and polypropylene 0.08 part; the traditional Chinese medicine sustained-release gel comprises traditional Chinese medicine extract solution 0.4 part and traditional Chinese medicine sustained-release skeleton material, and the traditional Chinese medicine extract solution is composed of forsythia suspensa extract solution and honeysuckle extract solution in a mass ratio of 0.5:1.

[0067] The preparation method of the combination of the forsythia suspensa extract and honeysuckle extract and the air purification sustained-release gel is the same as that in Embodiment 1.

[0068] Embodiment 7

[0069] The air purification sustained-release gel combination provided by the embodiment of the present application comprises a chlorine dioxide sustained-release gel and a traditional Chinese medicine sustained-release gel, wherein the chlorine dioxide sustained-release gel comprises the following components in parts by weight: 8% (w / v) oxalic acid aqueous solution 95 parts, sodium chlorite 6 parts and polypropylene 0.12 part; the traditional Chinese medicine sustained-release gel comprises traditional Chinese medicine extract 0.7 part and a traditional Chinese medicine sustained-release skeleton material, and the traditional Chinese medicine extract is composed of forsythia suspensa extract and honeysuckle extract in a mass ratio of 1.5:1.

[0070] The preparation method of the combination of the forsythia suspensa extract and honeysuckle extract and the air purification sustained-release gel is the same as that in Embodiment 1.

[0071] Embodiment 8

[0072] The air purification sustained-release gel combination provided by the embodiment of the present application comprises a chlorine dioxide sustained-release gel and a traditional Chinese medicine sustained-release gel, wherein the chlorine dioxide sustained-release gel comprises the following components in parts by weight: 12% (w / v) oxalic acid aqueous solution 95 parts, sodium chlorite 8 parts and polypropylene 0.15 part; the traditional Chinese medicine sustained-release gel comprises traditional Chinese medicine extract 0.8 part and a traditional Chinese medicine sustained-release skeleton material, and the traditional Chinese medicine extract is composed of forsythia suspensa extract and honeysuckle extract in a mass ratio of 2:1.

[0073] The preparation method of the combination of the forsythia suspensa extract and honeysuckle extract and the air purification sustained-release gel is the same as that in Embodiment 1.

[0074] Embodiment 9

[0075] The air purification sustained-release gel combination provided by the embodiment of the present application comprises a chlorine dioxide sustained-release gel and a traditional Chinese medicine sustained-release gel, wherein the chlorine dioxide sustained-release gel comprises the following components in parts by weight: 12% (w / v) oxalic acid aqueous solution 95 parts, sodium chlorite 8 parts and polypropylene 0.15 part; the traditional Chinese medicine sustained-release gel comprises traditional Chinese medicine extract 0.8 part and a traditional Chinese medicine sustained-release skeleton material, and the traditional Chinese medicine extract is composed of forsythia suspensa extract and honeysuckle extract in a mass ratio of 2:1.

[0076] Please refer to Figure 1 The structure of the gas release box is composed of a cylindrical solid storage part 1 and a liquid storage part 2. The solid storage part 1 comprises a dry powder storage cavity 11 for storing sodium chlorite and polypropylene and a gel storage cavity 12 for storing the traditional Chinese medicine sustained-release gel, and the bottom of the dry powder storage cavity 11 is a film 111. The liquid storage part 2 comprises a liquid storage cavity 21 for storing oxalic acid aqueous solution, a puncture part 22 for puncturing the film 111 at the bottom of the dry powder storage cavity 11, and a leakage hole 23 for causing sodium chlorite and polypropylene to leak into the liquid storage cavity. The top of the solid storage part 1 is provided with a gas adjusting mechanism 13 capable of closing the dry powder storage cavity 11 and the gel storage cavity 12 and adjusting the release of gas in the dry powder storage cavity 11 and the gel storage cavity 12.

[0077] In the embodiment, the gas adjusting mechanism 13 comprises an inner cover 131 threadedly connected with the solid storage part 1 and provided with inner vent holes 1311 for allowing the gas in the dry powder storage cavity 11 and the gel storage cavity 12 to escape, a sealing layer 133 arranged in the inner cavity of the inner cover 131 for sealing the dry powder storage cavity 11 and the gel storage cavity 12, and an outer cover 132 arranged outside the inner cover 131 and rotationally connected with the inner cover 131, the outer cover 132 being provided with outer vent holes 1321 for changing the vent area of the inner vent holes 1311. By rotating the outer cover 132 to change the position correspondence between the outer vent holes 1321 and the inner vent holes 1311, the vent area of the inner vent holes 1311 can be adjusted, so that the release amount of the chlorine dioxide in the dry powder storage cavity 11 and the volatile components of the traditional Chinese medicine in the gel storage cavity 12 can be adjusted.

[0078] The air purification box can isolate the sodium chlorite and the oxalic acid aqueous solution during the shelf life, avoid the reaction of the two, and solve the problem that the chlorine dioxide is not easy to store. The puncture part 22 punctures the film 111 at the bottom of the dry powder storage cavity 11 during use, so that the sodium chlorite and the polypropylene leak into the liquid storage cavity 21 through the material leakage hole 23 to mix with the oxalic acid aqueous solution to form the chlorine dioxide slow-release gel. The chlorine dioxide gas generated escapes through the material leakage hole 23, enters the dry powder storage cavity 11, and is released into the air through the gas adjusting mechanism 13. The gas adjusting mechanism 13 can avoid the volatilization of the volatile components of the traditional Chinese medicine extract in the traditional Chinese medicine slow-release gel during the shelf life, and avoid the leakage of the sodium chlorite and the polypropylene. In addition, the release amount of the chlorine dioxide gas and the volatile components of the traditional Chinese medicine extract in the traditional Chinese medicine slow-release gel can be adjusted during use.

[0079] Before use, the traditional Chinese medicine slow-release gel prepared in S1 of the embodiment 1 is placed in the gel storage cavity 12, and the sodium chlorite and the polypropylene are mixed and then placed in the dry powder storage cavity 11. The gas adjusting mechanism 13 is covered to seal the gel storage cavity 12 and the dry powder storage cavity 11. The oxalic acid aqueous solution is placed in the liquid storage cavity 21 and sealed with a sealing film or cover, or the oxalic acid aqueous solution is stored separately and poured into the liquid storage cavity 21 during use.

[0080] During use, the sealing layer 133 in the inner cavity of the inner cover 131 of the gas adjusting mechanism 13 is removed, and the solid storage part 1 and the liquid storage part 2 are connected by thread rotation. The puncture part 22 punctures the film 111 at the bottom of the dry powder storage cavity 11 during rotation, so that the sodium chlorite and the polypropylene leak into the liquid storage cavity 21 through the material leakage hole 23 to mix with the oxalic acid aqueous solution to form the chlorine dioxide slow-release gel. The chlorine dioxide gas generated escapes through the material leakage hole 23, enters the dry powder storage cavity 11, and is released into the air through the gas adjusting mechanism 13. By rotating the outer cover 132 of the gas adjusting mechanism 13, the release amount of the chlorine dioxide gas and the volatile components of the traditional Chinese medicine extract in the traditional Chinese medicine slow-release gel can be adjusted.

[0081] The air purification slow release gel combination in this example can also be replaced by the air purification slow release gel combinations in Examples 2-8.

[0082] Comparative Example 1

[0083] This comparative example provides an air purification slow release gel combination, which has the same components as Example 1.

[0084] The preparation method of the Forsythia extract is as follows: Forsythia is heated and refluxed with 7 times 55% v / v ethanol aqueous solution for 2 times, 30 min each time; the filtrate is combined and concentrated to 1.25 g / ml, and the Forsythia extract is obtained;

[0085] The preparation method of the Honeysuckle extract and the air purification slow release gel combination is the same as Example 1.

[0086] Comparative Example 2

[0087] This comparative example provides an air purification slow release gel combination, which has the same components as Example 1.

[0088] The preparation method of the Forsythia extract is as follows: Forsythia is heated and refluxed with 7 times 55% v / v ethanol aqueous solution for 2 times, 30 min each time; the filtrate is combined and concentrated to 1.25 g / ml, and the Forsythia extract is obtained;

[0089] The preparation method of the Honeysuckle extract and the air purification slow release gel combination is the same as Example 1.

[0090] Comparative Example 3

[0091] This comparative example provides an air purification slow release gel combination, which has the same components as Example 1.

[0092] The preparation method of the Honeysuckle extract is as follows: Honeysuckle is heated and refluxed with 7 times 57% v / v ethanol aqueous solution for 2 times, 30 min each time; the filtrate is combined and concentrated to 1.25 g / ml, and the Honeysuckle extract is obtained;

[0093] The preparation method of the Forsythia extract and the air purification slow release gel combination is the same as Example 1.

[0094] Comparative Example 4

[0095] This comparative example provides an air purification slow release gel combination, which has the same components as Example 1.

[0096] The preparation method of the Honeysuckle extract is as follows: Honeysuckle is heated and refluxed with 7 times 57% v / v ethanol aqueous solution for 2 times, 30 min each time; the filtrate is combined and concentrated to 1.25 g / ml, and the Honeysuckle extract is obtained;

[0097] The preparation method of the air purification sustained-release gel combination with the forsythia extract solution is the same as that in Example 1.

[0098] Comparative Example 5

[0099] This comparative example provides a chlorine dioxide sustained-release gel, which has the same components as the chlorine dioxide sustained-release gel in Example 1 and is prepared by the same method S2 as in Example 1.

[0100] Test Example 1

[0101] This test example investigates the bactericidal effect of the air purification sustained-release gel combinations prepared in Examples 1-8 and Comparative Examples 1-5 above.

[0102] The composition ratio of the nutrient agar medium used in the following experiments is: peptone 10 g, beef extract 3 g, sodium chloride 5 g, agar 17 g, distilled water 1000 mL;

[0103] The composition of the Sabouraud medium is: peptone 10 g, agar 20 g, glucose 40 g, distilled water 1 L.

[0104] 1. Experimental method

[0105] The nutrient agar medium slant culture (24 h) of the test bacteria of the 5th generation was washed with 5 mL of 0.03 mol / L phosphate buffer (hereinafter referred to as PBS) to remove the bacterial mat, and was diluted with the above PBS to prepare a bacterial suspension with a concentration of 5x10 4 cfu / ml.

[0106] The air purification sustained-release gel combinations prepared in Examples 1-8 and Comparative Examples 1-4 and the chlorine dioxide sustained-release gel prepared in Comparative Example 5 were used as the test samples. 0.1 ml of the bacterial suspension was spread on the surface of the nutrient agar medium (bacteria) or the Sabouraud medium (yeast), and four samples were prepared for each test sample, and were placed in a 36°C 1m 3 incubator with 10 g of the test sample; another 0.1 ml of the bacterial suspension was spread on the surface of the nutrient agar medium and placed in another 36°C 1m 3 incubator as a blank control (four samples were prepared). The viable bacterial colony counts were taken at 30 min, 2 h, 6 h, 12 h, 18 h, and 24 h, respectively.

[0107] The test was repeated three times, and the bacteriostatic rate was calculated according to the following formula:

[0108] X = (A-B) / A x 100%

[0109] In the formula, X is the bacteriostatic rate, A is the average number of colonies of the blank control, and B is the average number of colonies of the test sample.

[0110] The average bacteriostatic rate of the air purification slow-release gel combination prepared in each embodiment and the comparative example at different action times was recorded, and the bacteriostatic logarithmic value was calculated, and the results are shown in Tables 1-3.

[0111] Table 1: Bacteriostatic data against Staphylococcus aureus

[0112]

[0113] Table 2: Bacteriostatic data against Escherichia coli

[0114]

[0115]

[0116] Table 3: Bacteriostatic data against Candida albicans

[0117]

[0118] As can be seen from the test results in Tables 1-3, the bacteriostatic rates of the air purification slow-release gel combinations prepared in Examples 1-5 against Staphylococcus aureus, Escherichia coli and Candida albicans are all >99.999% at 30 min-24 h, the bacteriostatic rates of the air purification slow-release gel combinations prepared in Examples 6 and 7 against Staphylococcus aureus, Escherichia coli and Candida albicans are all >99.99% at 30 min-24 h, and the bacteriostatic rate of the air purification slow-release gel combination prepared in Example 8 against Staphylococcus aureus, Escherichia coli and Candida albicans is >99.9% at 30 min-24 h. In addition, the bacteriostatic rate of Example 1 is better than that of Comparative Examples 1-4 which have the same formula but different preparation methods.

[0119] Test Example 2

[0120] This test example investigates the toxicological safety of the chlorine dioxide slow-release gel prepared in Example 1.

[0121] 1. Experimental method

[0122] The chlorine dioxide slow-release gel prepared in S2 in Example 1 was used as the test sample.

[0123] (1) Acute oral toxicity test:

[0124] Sample preparation: 5 g ± 0.0025 g of the test sample was accurately weighed into a 20 ml volumetric flask, and purified water was added to the calibration mark to make up the volume, and mixed uniformly for use, with a final concentration of about 250 mg / ml (based on the mass of the test sample).

[0125] Experimental method: 4-week-old Kunming mice, half male and half female, were fasted overnight before the test, but water was not restricted. The amount of intragastrically administered was 5000 mg / kg·bw (based on the mass of the test product), and the intragastric volume was 20 ml / kg. After exposure, the animals were observed for signs of poisoning and the number and time of death, and the dead animals and animals sacrificed at the end of the observation period were autopsied, observed macroscopically, and when abnormal tissues and organs were found, further histopathological screening was performed. The observation period for symptoms was 14 days.

[0126] (2) Acute inhalation toxicology experiment

[0127] Experimental method: 4-week-old Kunming mice, half male and half female, were fasted overnight before the test, but water was not restricted. The amount of intragastrically administered was 5000 mg / kg·bw (based on the mass of the test product), and the intragastric volume was 20 ml / kg. After exposure, the animals were observed for signs of poisoning and the number and time of death, and the dead animals and animals sacrificed at the end of the observation period were autopsied, observed macroscopically, and when abnormal tissues and organs were found, further histopathological screening was performed. The observation period for symptoms was 14 days. 3 , and inhaled for 2 hours. The animals were observed for symptoms at any time during the exposure, and once a day. The time of appearance and disappearance of signs of poisoning and the time of death should be recorded. The observation period was 14 days.

[0128] 2. Experimental results

[0129] The results are shown in Tables 4 and 5.

[0130] Table 4 Results of acute oral toxicity test

[0131]

[0132] The results of the acute oral toxicity test showed that there were no signs of poisoning and poisoning deaths in the experimental animals within 14 days, and the body weights of male and female animals were not abnormal. At the end of the actual observation, gross autopsy of the test animals also showed no abnormal changes. Therefore, under the conditions of this experiment, the oral LC 50 of the test product for KM mice was >5000 mg / kg·bw, and according to the acute toxicity classification standard of the Disinfection Technical Specification (2002 edition), the acute oral toxicity test of this sample was actually non-toxic.

[0133] Table 5 Results of acute inhalation toxicity test

[0134]

[0135] The results of the acute inhalation toxicity test showed that there were no signs of poisoning and poisoning deaths in the experimental animals within 14 days, and the body weights of male and female animals were not abnormal. At the end of the actual observation, gross autopsy of the test animals also showed no abnormal changes. Therefore, under the conditions of this experiment, the inhalation LC 50 of the test product for male and female mice was >10000 mg / m 3According to the acute inhalation toxicity evaluation standard of the Disinfection Technical Standard (2002 edition), the sample is practically non-toxic in the acute inhalation toxicity test.

[0136] Test Example 3

[0137] In this test example, the products prepared in Examples 1 to 8 and Comparative Examples 1 to 5 above were subjected to product trial investigation.

[0138] 1. Experimental purpose: to test the degree of liking of the consumers for the odor of the products prepared in Examples 1 to 8 and Comparative Examples 1 to 5 above.

[0139] 2. Experimental method:

[0140] The air purification slow-release gel combination of Examples 1 to 8 and Comparative Examples 1 to 4 and the chlorine dioxide slow-release gel of Comparative Example 5 were each made into an air purification box using the gas release box of Example 9, to serve as the sample to be tested in this test example.

[0141] Fifteen women and fifteen men, a total of 30 trial users, were randomly selected to use the samples, and after the trial was completed, they were asked to fill out a trial investigation form, and the investigation results were counted. Among them, 1 point was very much disliked, 2 points was disliked, 3 points was general, 4 points was liked, and 5 points was very much liked.

[0142] 3. Experimental data analysis

[0143] The experimental results are shown in Table 6.

[0144] Table 6: Results of consumer trial investigation

[0145]

[0146] The above investigation results show that the average score of the degree of liking of the trial users for Examples 1 to 8 of the present application was the highest, at 4.77 points, and they fed back that the fragrance was moderate and the fresh air effect was obvious; the average score of the degree of liking for Comparative Example 5 was 2.93, and they fed back that the chlorine dioxide odor was too obvious, and when close to it, there was a pungent smell, although it could eliminate odor, but the fresh air effect was not as good as that of Examples 1 to 8; the average score of the degree of liking for Comparative Examples 1, 2 and 4 was 2.73 to 3.33, and during the trial period, the fragrance of the volatile oil could be obviously experienced, but the odor elimination effect was somewhat worse than that of Examples 1 to 8, and there was feedback that the fragrance was too strong; the odor elimination effect of Comparative Example 3 was far worse than that of Examples 1 to 8, the fragrance was slightly weak, and the fresh air effect was not obvious. The products of Examples 1 to 8 had the most obvious bactericidal and odor-eliminating fresh air effect, and were most liked by consumers.

[0147] The above merely describes preferred embodiments of the present application, and is not used to limit the present application, any modification, equivalent replacement or improvement made within the spirit and principle of the present application should be included in the protection scope of the present application.

Claims

1. An air purifying slow release gel composition, characterized in that, The air purification sustained-release gel comprises a chlorine dioxide sustained-release gel and a traditional Chinese medicine sustained-release gel, the chlorine dioxide sustained-release gel comprises the following components in weight percentage: 80-95 parts of 2.5-12% (w / v) oxalic acid aqueous solution, 2-8 parts of sodium chlorite and 0.08-0.15 part of polypropylene; the traditional Chinese medicine sustained-release gel comprises 0.4-0.8 part of traditional Chinese medicine extract and a traditional Chinese medicine sustained-release skeleton material; the particle size of the polypropylene is less than 0.18 μm; The traditional Chinese medicine extract comprises forsythia suspense extract and honeysuckle extract, and the mass ratio of the forsythia suspense extract to the honeysuckle extract is 0.5-2:1; The preparation method of the forsythia suspense extract is as follows: The forsythia suspense is extracted by heating reflux with 45-65% v / v ethanol aqueous solution whose pH is adjusted to 8-8.5 by sodium hydroxide; after the extraction, the obtained filtrate is filtered, concentrated, eluted by 85-95% v / v ethanol aqueous solution, then eluted by water, the water elution flow fraction is collected, and the collected water elution flow fraction is concentrated to 1.2-1.3 g / ml to obtain the forsythia suspense extract; the mass of the 45-65% v / v ethanol aqueous solution is 5-8 times of the mass of the forsythia suspense; The preparation method of the honeysuckle extract is as follows: The honeysuckle is extracted by heating reflux with 55-60% v / v ethanol aqueous solution whose pH is adjusted to 8-8.5 by sodium hydroxide, the obtained residue is extracted by heating reflux with 25-35% v / v ethanol aqueous solution, the obtained filtrate is filtered, and the obtained filtrate is concentrated to 1.2-1.3 g / ml to obtain the honeysuckle extract; The above air purification sustained-release gel combination is stored in a gas release box; the gas release box is composed of a solid storage part and a liquid storage part which are detachably connected, the solid storage part comprises a dry powder storage cavity for storing the sodium chlorite and the polypropylene and a gel storage cavity for storing the traditional Chinese medicine sustained-release gel, the bottom of the dry powder storage cavity is a film; the liquid storage part comprises a liquid storage cavity for storing the oxalic acid aqueous solution, a puncture part for puncturing the film at the bottom of the dry powder storage cavity, and a leakage hole for causing the sodium chlorite and the polypropylene to leak into the liquid storage cavity; the top of the solid storage part is provided with a gas adjusting mechanism which can close the dry powder storage cavity and the gel storage cavity and adjust the release of gas in the dry powder storage cavity and the gel storage cavity.

2. The air purifying slow release gel composition of claim 1, wherein, The chlorine dioxide sustained-release gel comprises the following components in weight percentage: 80-95 parts of 2.5-8% (w / v) oxalic acid, 2-6 parts of sodium chlorite and 0.08-0.12 part of polypropylene.

3. The air purifying slow release gel composition of claim 2, wherein, The chlorine dioxide sustained-release gel comprises the following components in weight percentage: 80-95 parts of 4-6.5% (w / v) oxalic acid, 3-5 parts of sodium chlorite and 0.08-0.1 part of polypropylene.

4. The air purifying slow release gel composition according to any one of claims 1 to 3, wherein, The traditional Chinese medicine sustained-release skeleton material is polypropylene.

5. A method of making the air purifying slow release gel composition of any one of claims 1 to 4, characterized in that, The method comprises the following steps: S1, soaking the traditional Chinese medicine sustained-release skeleton material in the traditional Chinese medicine extract until saturated absorption, and taking out to obtain the traditional Chinese medicine sustained-release gel; S2, mixing the sodium chlorite and the polypropylene, and mixing the sodium chlorite and the polypropylene with the oxalic acid aqueous solution before use to obtain the chlorine dioxide sustained-release gel; S3, releasing the Chinese medicine sustained-release gel and the chlorine dioxide sustained-release gel through the gas releasing container.

6. An air purification cartridge, characterized by, The air purification sustained-release gel combination comprises the gas releasing box and the air purification sustained-release gel according to any one of claims 1-4; The gas releasing box is composed of a solid storage part and a liquid storage part which are detachably connected, the solid storage part comprises a dry powder storage cavity for storing the sodium chlorite and polypropylene and a gel storage cavity for storing the Chinese medicine sustained-release gel, the bottom of the dry powder storage cavity is a film; the liquid storage part comprises a liquid storage cavity for storing the oxalic acid aqueous solution, a puncture part for puncturing the film at the bottom of the dry powder storage cavity, and a leakage hole for making the sodium chlorite and polypropylene leak into the liquid storage cavity; The top of the solid storage part is provided with a gas adjusting mechanism capable of closing the dry powder storage cavity and the gel storage cavity and adjusting the gas release in the dry powder storage cavity and the gel storage cavity.

7. The air purification cartridge of claim 6, wherein, The solid storage part and the liquid storage part are both cylindrical, and the solid storage part and the liquid storage part are threadedly and fitly connected.

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