An online centrifugation system

Abstract

The present invention discloses an online centrifugation system, which includes a conveying device, a balancing and weighing mechanism, a manipulator and a centrifuge; the conveying device, the balancing and weighing mechanism and the centrifuge are arranged in sequence; the conveying device is used for conveying a sample tray for holding blood collection tubes, the balancing and weighing mechanism is used for weighing an adapter, and the centrifuge is used for centrifuging the blood collection tubes; the manipulator is respectively used for grasping the blood collection tubes and the adapter to complete the conveyance of the blood collection tubes between the adapter and the conveying device, and the conveyance of the adapter between the centrifuge and the balancing and weighing mechanism. An inlet and outlet window is provided on the centrifuge, and the adapter enters and exits the centrifuge through the inlet and outlet window. The present invention balances the adapter through the balancing and weighing mechanism, meeting the balancing requirements of the adapter.

Description

Technical Field

[0001] The present invention relates to the technical field of devices for on-line centrifugation of blood in an automated pipeline system in a laboratory, and more particularly to an on-line centrifugation system. Background Art

[0002] Currently, for the centrifugation of blood collection tubes, an adapter needs to be placed, and the adapter is placed in a centrifuge to centrifuge the blood collection tube. Whether the adapter meets the balance requirement cannot be guaranteed.

[0003] Therefore, how to meet the balancing requirement of the adapter is an urgent problem to be solved by those skilled in the art at present. Summary of the Invention

[0004] In view of this, the purpose of the present invention is to provide an on-line centrifugation system that can meet the balancing requirement of the adapter.

[0005] To achieve the above purpose, the present invention provides the following solutions:

[0006] An on-line centrifugation system, comprising a conveying device, a balancing weighing mechanism, a manipulator, and a centrifuge;

[0007] The conveying device, the balancing weighing mechanism, and the centrifuge are arranged in sequence;

[0008] The conveying device is used for conveying a sample tray for holding blood collection tubes, the balancing weighing mechanism is used for weighing the adapter, and the centrifuge is used for centrifuging the blood collection tubes;

[0009] The manipulator is respectively used for grasping the blood collection tube and the adapter to complete the conveyance of the blood collection tube between the adapter and the conveying device, and the conveyance of the adapter between the centrifuge and the balancing weighing mechanism;

[0010] An inlet and outlet window is provided on the centrifuge, and the adapter enters and exits the centrifuge through the inlet and outlet window.

[0011] In a specific embodiment, the on-line centrifugation system further comprises a sample tray buffer device;

[0012] The sample tray buffer device is used for supplying empty sample trays to the conveying device.

[0013] In another specific embodiment, the sample tray buffer device is arranged perpendicular or parallel to the conveying device.

[0014] In another specific embodiment, the conveying device comprises a first conveying device, a second conveying device, a third conveying device, a first reversing mechanism, a second reversing mechanism, and a third reversing mechanism;

[0015] The first conveying device is used to convey the sample tray for holding blood collection tubes. Along the conveying direction of the first conveying device, a first outlet and a first inlet are successively formed on the side wall of the first conveying device. The first outlet is conductively connected to the input port of the second conveying device. The first reversing mechanism is arranged at the intersection of the first outlet and the output port of the second conveying device, and is used to control the sample tray containing the uncentrifuged blood collection tubes to enter the second conveying device;

[0016] Along the conveying direction of the second conveying device, a second inlet is formed on the side wall of the second conveying device. The second inlet is conductively connected to the output port of the sample tray buffer device. The second reversing mechanism is arranged at the intersection of the second inlet and the output port of the sample tray buffer device, and is used to control the empty sample tray to enter the second conveying device;

[0017] The output port of the second conveying device is conductively connected to both the input port of the sample tray buffer device and the first inlet. The third reversing mechanism is arranged at the intersection of the output port of the second conveying device and the input port of the sample tray buffer device and the first inlet, and is used to control the empty sample tray to enter the sample tray buffer device, and control the sample tray containing the centrifuged blood collection tubes to enter the first conveying device.

[0018] In another specific embodiment, the structures of the first reversing mechanism, the second reversing mechanism and the third reversing mechanism are the same, and each includes a driving part and a reversing part;

[0019] The driving part is used to drive the reversing part to move, and the reversing part guides the sample tray to realize the reversing of the sample tray.

[0020] In another specific embodiment, the online centrifugation system further includes a reading mechanism;

[0021] The reading mechanism is arranged on the side wall of the first conveying device and is used to read the centrifugation information of the blood collection tubes on the first conveying device;

[0022] When the sample tray on the second conveying device does not hold a blood collection tube, the rotary barcode scanning mechanism unbinds the blood collection tube barcode on the sample tray, and the third reversing mechanism controls the output port of the second conveying device to be conductively connected to the input port of the sample buffer device;

[0023] When the sample tray on the second conveying device holds a blood collection tube, the rotary barcode scanning mechanism binds the blood collection tube barcode to the sample tray, and the third reversing mechanism controls the output port of the second conveying device to be conductively connected to the first inlet.

[0024] In another specific embodiment, the online centrifugation system further includes a rotary barcode scanning mechanism;

[0025] The rotary code scanning mechanism is located on the side wall of the second conveying device and is used to scan the information of the blood collection tubes on the second conveying device;

[0026] When the sample tray on the second conveying device does not hold a blood collection tube, the third commutation mechanism controls the output port of the second conveying device to communicate with the input port of the sample buffer device;

[0027] When the sample tray on the second conveying device holds a blood collection tube, the third commutation mechanism controls the output port of the second conveying device to communicate with the first inlet.

[0028] In another specific embodiment, the sample tray buffer device includes a steering mechanism, guide rails, and a plurality of synchronous belts arranged in parallel. The guide rails are arranged on both sides of the synchronous belts and are used for guiding the sample trays;

[0029] The conveying directions between adjacent synchronous belts are opposite. The steering mechanism is arranged between adjacent synchronous belts and is used for steering the conveyance of the sample trays on adjacent synchronous belts.

[0030] In another specific embodiment, the steering mechanism includes a steering plate, a roller, and a driving component. The roller is arranged between adjacent synchronous belts, and the driving component is in transmission connection with the roller and is used to drive the roller to rotate;

[0031] The steering plate is an arc-shaped plate and is arranged on both sides of the steering plate and is used to guide the sample tray from one synchronous belt to an adjacent synchronous belt.

[0032] In another specific embodiment, the balancing and weighing mechanism includes a bottom plate and a weighing device;

[0033] At least one weighing hole for placing the weighing device is formed on the bottom plate, and the weighing device is used for weighing the adapter.

[0034] In another specific embodiment, a receiving groove that fits the shape of the adapter is formed on the bottom plate. The bottom of the receiving groove is in conduction connection with the top end of the weighing hole, and the top end of the weighing device extends into the receiving groove.

[0035] In another specific embodiment, the balancing and weighing mechanism further includes a balancing rack;

[0036] The balancing rack is installed on the bottom plate and is used for placing balancing tubes.

[0037] In another specific embodiment, the manipulator includes a bracket, a pipe gripper, and an adapter gripper;

[0038] The pipe gripper and the adapter gripper are each slidably mounted on the bracket along the X, Y, and Z directions;

[0039] The pipe gripper is used to grip blood collection tubes or balancing tubes;

[0040] The adapter gripper is used to grip the adapter.

[0041] In another specific embodiment, the bracket includes an X-axis bracket, a Y-axis bracket, and a Z-axis bracket;

[0042] The Y-axis bracket is slidably mounted on the X-axis bracket along the X direction, the Z-axis bracket is slidably mounted on the Y-axis bracket along the Y direction, and the pipe gripper and the adapter gripper are respectively slidably mounted on both sides of the Z-axis bracket along the Z direction.

[0043] In another specific embodiment, the on-line centrifugation system further includes a main control system, an interface control system, and an electric control system;

[0044] The main control system is respectively signal-connected to the interface control system, the electric control system, and the centrifuge;

[0045] The electric control system is used to control the operation of the conveying device, the balancing and weighing of the balancing and weighing mechanism, the movement of the manipulator, the operation of the sample tray buffer device, the movement of the reading mechanism, and the movement of the rotary code scanning mechanism

[0046] The various embodiments according to the present invention can be arbitrarily combined as needed, and the embodiments obtained after these combinations are also within the scope of the present invention and are part of the specific embodiments of the present invention.

[0047] Without being limited to any theory, from the above disclosure, it can be seen that when using the on-line centrifugation system, the sample tray containing the blood collection tube enters the conveying device from the input port of the conveying device, and the conveying device conveys the sample tray; when the sample tray reaches the position where the manipulator can grip it, the manipulator grips the blood collection tube on the sample tray and places it on the adapter of the balancing and weighing mechanism for balancing; when the adapter is balanced, the manipulator grips the adapter and places it in the centrifuge for centrifugation; when the centrifugation is completed, the manipulator takes out the adapter from the centrifuge and places it on the balancing and weighing mechanism; then, the centrifuged blood collection tube on the adapter is placed on the empty sample tray on the conveying device, and the centrifuged blood collection tube is conveyed to the next station. The present invention balances the adapter through the balancing and weighing mechanism, meeting the balancing requirements of the adapter. Description of the Drawings

[0048] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for the description of the embodiments or the prior art. Obviously, the drawings in the following description are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on these drawings.

[0049] Figure 1 The top view structural schematic diagram of the online centrifugal system provided by the present invention;

[0050] Figure 2 The partial structural schematic diagram of the sample tray caching device provided by the present invention;

[0051] Figure 3 The partial structural schematic diagram of the steering mechanism provided by the present invention;

[0052] Figure 4 The three-dimensional structural schematic diagram of the trimming and weighing mechanism provided by the present invention;

[0053] Figure 5 The three-dimensional structural schematic diagram of the manipulator provided by the present invention;

[0054] Figure 6 The three-dimensional structural schematic diagram of the transmission blocking device provided by the present invention;

[0055] Figure 7 The three-dimensional structural schematic diagram of the reading mechanism provided by the present invention.

[0056] Among them, Figure 1-7 In:

[0057] Conveyor device 1, first conveyor device 101, second conveyor device 102, third conveyor device 103, first reversing mechanism 104, second reversing mechanism 105, third reversing mechanism 106, balancing and weighing mechanism 2, bottom plate 201, weighing device 202, receiving groove 2011, balancing frame 203, manipulator 3, support 301, pipe gripper 302, adapter gripper 303, X-axis support 3011, Y-axis support 3012, Z-axis support 3013, centrifuge 4, sample holder 9, blood collection tube 11, adapter 5, sample holder buffer device 6, steering mechanism 601, guide rail 602, synchronous belt 603, steering plate 6011, idler roller 6012, drive assembly 6013, reading mechanism 7, rotating code scanning mechanism 8, inlet and outlet window 401, blood collection tube return conveyor belt 10, picking and placing position 107, transmission blocking device 12, gear 1201, first rack 1202, second rack 1203, first stop post 1204, second stop post 1205, first sensor 1206, second sensor 1207, rotating device 701, camera 702, blocking member 703, light source 704, plane mirror 705, driven wheel 7011, driving wheel 7012, balancing tube 13. Detailed implementation mode

[0058] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0059] In the description of the present invention, it should be understood that the orientation or positional relationship indicated by the terms "upper", "lower", "top surface", "bottom surface", etc. is based on the orientation or positional relationship shown in the accompanying drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the indicated position or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of the present invention. In addition, the terms "first" and "second" are only used for descriptive purposes and cannot be construed as indicating or implying relative importance.

[0060] As Figure 1 shown, the present invention discloses an on-line centrifugation system for on-line centrifugation of blood collection tubes 11.

[0061] Specifically, the on-line centrifugation system includes a conveyor device 1, a balancing and weighing mechanism 2, a manipulator 3, and a centrifuge 4.

[0062] The conveying device 1, the balancing and weighing mechanism 2, and the centrifuge 4 are arranged in sequence. To reduce the space occupied by the online centrifugation system, the conveying device 1, the balancing and weighing mechanism 2, and the centrifuge 4 are arranged adjacent to each other to avoid the problem of large space occupation caused by excessive spacing between them.

[0063] The conveying device 1 is used to convey the sample tray 9 containing the blood collection tube 11. Specifically, the conveying device 1 can be any device capable of realizing the conveyance of the sample tray 9, and the specific structure is not limited.

[0064] The balancing and weighing mechanism 2 is used to weigh the adapter 5. By placing the blood collection tube 11 on the adapter 5 and weighing it, the balancing of the adapter 5 is realized.

[0065] The centrifuge 4 is used to centrifuge the blood collection tube 11. Specifically, an inlet and outlet window 401 is opened on the centrifuge 4, and the adapter 5 enters and exits the centrifuge 4 through the inlet and outlet window 401.

[0066] The manipulator 3 is respectively used to grasp the blood collection tube 11 and the adapter 5 to complete the conveyance of the blood collection tube 11 between the adapter 5 and the conveying device 1, and the conveyance of the adapter 5 between the centrifuge 4 and the balancing and weighing mechanism 2.

[0067] It should be noted that the conveying device 1, the balancing and weighing mechanism 2, the manipulator 3, and the centrifuge 4 can share the same frame or can be separate frames, which can be specifically set according to needs.

[0068] When using the online centrifugation system, the sample tray containing the blood collection tube 11 enters the conveying device 1 from the input port of the conveying device 1, and the conveying device 1 conveys the sample tray 9; when the sample tray 9 reaches the position where the manipulator 3 can grasp it, the manipulator 3 grasps the blood collection tube 11 on the sample tray 9 and places it on the adapter 5 of the balancing and weighing mechanism 2. If balancing is required, the manipulator 3 grasps the balancing tube 13 on the balancing rack 203 and places it at the corresponding position of the adapter 5 for balancing; after the adapter 5 is balanced, the manipulator 3 grasps the adapter 5 and puts it into the centrifuge 4 for centrifugation; when the centrifugation is completed, the manipulator 3 takes out the adapter 5 from the centrifuge 4 and places it on the balancing and weighing mechanism 2; then, the centrifuged blood collection tube 11 on the adapter 5 is placed on the empty sample tray 9 on the conveying device 1, and the centrifuged blood collection tube 11 is conveyed to the next working station. The present invention balances the adapter 5 through the balancing and weighing mechanism 2, meeting the balancing requirements of the adapter 5.

[0069] In some embodiments, the online centrifugation system further includes a sample tray buffer device 6, and the sample tray buffer device 6 is arranged perpendicular or parallel to the conveying device 1.

[0070] The sample tray buffer device 6 is used to supply empty sample trays 9 to the conveying device 1 to enable the empty sample trays 9 to be timely placed when the manipulator 3 takes out the centrifuged blood collection tube 11 from the adapter 5.

[0071] Further, as Figure 2 shown, the present invention specifically discloses that the sample holder caching device 6 includes a steering mechanism 601, a guide rail 602, and a plurality of synchronous belts 603 arranged in parallel. The guide rail 602 is arranged on both sides of the synchronous belts 603 and is used for guiding the sample holder 9. When the synchronous belts 603 are started, they drive the sample holder 9 to move along the guide rail 602, thereby realizing the transportation of the blood collection tube 11.

[0072] It should be noted that the synchronous belts 603 can also be replaced by chains. A support plate is fixedly laid on the chains, and the support plate drives the sample holder 9 to move.

[0073] The transportation directions between adjacent synchronous belts 603 are opposite. The steering mechanism 601 is arranged between adjacent synchronous belts 603 and is used for steering the transportation of the sample holder 9 on the adjacent synchronous belts 603. Setting a plurality of synchronous belts 603 makes the structure of the entire sample holder caching device 6 compact.

[0074] Even further, as Figure 3 shown, the present invention discloses that the steering mechanism 601 includes a steering plate 6011, a roller 6012, and a driving assembly 6013. The roller 6012 is arranged between adjacent synchronous belts 603. The driving assembly 6013 is in transmission connection with the roller 6012 and is used for driving the roller 6012 to rotate. The roller 6012 drives the sample holder 9 from one synchronous belt 603 to the adjacent synchronous belt 603.

[0075] The steering plate 6011 is an arc-shaped plate and is arranged on both sides of the steering plate 6011 for guiding the sample holder 9 from one synchronous belt 603 to the adjacent synchronous belt 603.

[0076] It should be noted that the steering mechanism 601 is not limited to the above structure and can also be a conveyor belt arranged at the same end of the synchronous belt 603 to realize the transportation from one synchronous belt 603 to the adjacent synchronous belt 603.

[0077] In some embodiments, the length of the conveying device 1 is greater than the lengths of the balancing and weighing mechanism 2 and the centrifuge 4. The lengths of the balancing and weighing mechanism 2 and the centrifuge 4 are preferably set to be equal or approximately equal. The sample holder caching device 6 is arranged at the gap formed by the conveying device 1, the balancing and weighing mechanism 2, and the centrifuge 4, making the entire online centrifugation system compact.

[0078] Further, the present invention discloses that the conveying device 1 includes a first conveying device 101, a second conveying device 102, a third conveying device 103, a first reversing mechanism 104, a second reversing mechanism 105, and a third reversing mechanism 106.

[0079] The first conveying device 101 is used to convey the sample tray 9 containing the blood collection tube 11. Along the conveying direction of the first conveying device 101, a first outlet and a first inlet are successively formed on the side wall of the first conveying device 101. The first outlet is conductively connected to the input port of the second conveying device 102. The first reversing mechanism 104 is arranged at the intersection of the first outlet and the output port of the second conveying device 102, and is used to control the sample tray 9 containing the uncentrifuged blood collection tube 11 to enter the second conveying device 102. Specifically, when the blood collection tube 11 on the sample tray 9 conveyed by the first conveying device 101 is not centrifuged, the first reversing mechanism 104 conducts the first outlet and the input port of the second conveying device 102, so that the sample tray 9 containing the blood collection tube 11 enters the second conveying device 102; when the blood collection tube 11 on the sample tray 9 conveyed by the first conveying device 101 has been centrifuged, the first reversing mechanism 104 blocks the first outlet from conducting the input port of the second conveying device 102, so that the sample tray 9 containing the blood collection tube 11 continues to be conveyed along the first conveying device 101 to the next operation. It should be noted that when the first reversing mechanism 104 conducts the first outlet and the input port of the second conveying device 102, the first outlet is cut off from the output port of the first conveying device 101; when the first outlet is cut off from the input port of the second conveying device 102, the first outlet is conductively connected to the output port of the first conveying device 101.

[0080] Along the conveying direction of the second conveying device 102, a second inlet is formed on the side wall of the second conveying device 102. The second inlet is conductively connected to the output port of the sample tray buffer device. The second reversing mechanism 105 is arranged at the intersection of the second inlet and the output port of the sample tray buffer device 6, and is used to control the empty sample tray 9 to enter the second conveying device 102. Specifically, when the first conveying device 101 conveys the uncentrifuged blood collection tube 11 to the second conveying device 102, the second inlet is cut off from the output port of the sample tray buffer device 6, and the second inlet is conductively connected to the output port of the second conveying device 102. Along the conveying direction of the second conveying device 102, a pick-and-place position 107 is arranged between the second inlet and the output port of the second conveying device 102. The pick-and-place position 107 is the position where the manipulator 3 can pick and place the blood collection tube 11. When the empty sample tray 9 in the sample tray buffer device 6 enters the second conveying device 102, the input port of the sample tray buffer device 6 is conductively connected to the second inlet, and the second inlet is cut off from the output port of the second conveying device 102.

[0081] The output port of the second conveying device 102 is connected in a conducting manner to both the input port and the first inlet of the sample tray buffer device 6. The third commutation mechanism 106 is arranged at the intersection of the output port of the second conveying device 102 with the input port and the first inlet of the sample tray buffer device 6, and is used to control the empty sample tray 9 to enter the sample tray buffer device 6, and control the sample tray 9 containing the centrifuged blood collection tube 11 to enter the first conveying device 101. Specifically, when the sample tray 9 conveyed by the second conveying device 102 is an empty sample tray 9 without a blood collection tube 11, the output port of the second conveying device 102 is in conduction with the input port of the sample tray buffer device 6, and the output port of the second conveying device 102 is cut off from the first inlet, and the empty sample tray 9 enters the sample tray buffer device 6; when the sample tray 9 conveyed by the second conveying device 102 is a sample tray 9 without a centrifuged blood collection tube 11, the output port of the second conveying device 102 is in conduction with the first inlet, and the output port of the second conveying device 102 is cut off from the input port of the sample tray buffer device 6, and the sample tray 9 enters the first conveying device 101 and then enters the next working station.

[0082] Specifically, the first conveying device 101, the second conveying device 102, and the third conveying device 103 all include a conveyor belt and a slide rail. The slide rails are arranged on both sides of the conveyor belt and are used for guiding the sample tray 9. When the conveyor belt moves, it drives the sample tray 9 to move along the slide rail.

[0083] It should be noted that the conveyor belt can also be replaced by a sprocket chain. The structures of the first conveying device 101, the second conveying device 102, and the third conveying device 103 are not limited to being the same, and different structures can also be set.

[0084] Furthermore, the present invention discloses that the online centrifugation system further includes a blood collection tube return conveyor belt 10. The blood collection tube return conveyor belt 10 is arranged in parallel with the first conveying device 101 and has an opposite conveying direction, and is used to output the blood collection tube 11 output from the output port of the first conveying device 101 to the next working station.

[0085] In some embodiments, the structures of the first commutation mechanism 104, the second commutation mechanism 105, and the third commutation mechanism 106 are the same, and all include a driving part and a commutation part.

[0086] The driving part is used to drive the commutation part to move, and the commutation part guides the sample tray 9 to achieve the commutation of the sample tray 9. Taking the movement of the sample tray 9 on the first conveying device 101 to the second conveying device 102 as an example, the driving part drives the commutation part to rotate to the first conveying device 101, so that the commutation part blocks the input port and the output port of the first conveying device 101, so that the first outlet of the first conveying device 101 is in conduction with the input port of the second conveying device 102. The blocking part is arc-shaped and extends to the second conveying device 102, so that under the conveying of the first conveying device 101, it enters the second conveying device 102 along the blocking part.

[0087] It should be noted that the driving part and the commutation part can also be other structures.

[0088] In order to make the distances between the sample carriers 9 on the conveying device 1 equal, the present invention discloses that the online centrifugation system further includes a transmission blocking device 12, as Figure 6 shown, the transmission blocking device 12 includes a mounting frame, a motor, a gear 1201, a first rack 1202, a second rack 1203, a first stop post 1204 and a second stop post 1205. The first rack 1202 and the second rack 1203 are respectively slidably mounted on the mounting frame. The gear 1201 is disposed between the first rack 1202 and the second rack 1203, and the gear 1201 is respectively meshed with the first rack 1202 and the second rack 1203 for transmission. The first stop post 1204 is fixed on the first rack 1202, and the second stop post 1205 is fixed on the second rack 1203.

[0089] The distance between the first stop post 1204 and the second stop post 1205 can accommodate one sample carrier 9, or two sample carriers 9, etc.

[0090] Along the moving direction of the sample carrier 9, taking the first stop post 1204 in the front and the second stop post 1205 in the rear, and the distance between the first stop post 1204 and the second stop post 1205 accommodating one sample carrier 9 as an example, during the transmission of the sample carrier 9, when it is necessary to block the sample carrier 9 from moving forward, the first stop post 1204 extends out, and the second stop post 1205 retracts, blocking all the sample carriers 9 behind. When it is necessary for the sample carrier 9 to continue moving forward along this direction, the first stop post 1204 retracts, and the second stop post 1205 extends out. The foremost sample carrier 9 passes through, and the subsequent sample carriers 9 are blocked by the second stop post 1205, and so on in a cycle to achieve single - sample - carrier - 9 transmission and release at a time.

[0091] For the convenience of control, the present invention discloses that the online centrifugation system further includes a first sensor 1206 and a second sensor 1207. The first sensor 1206 and the second sensor 1207 are symmetrically mounted on both sides of the mounting frame, and are respectively used to detect the first stop post 1204 and the second stop post 1205. When the first stop post 1204 is fully retracted and has no blocking effect, the first sensor 1206 detects the first stop post 1204. When the second stop post 1205 is fully retracted and has no blocking effect, the second sensor 1207 detects the second stop post 1205.

[0092] In some embodiments, the online centrifugation system further includes a reading mechanism 7. The reading mechanism 7 is disposed on the side wall of the first conveying device 101 and is used to read the centrifugation information of the blood collection tubes 11 on the first conveying device 101.

[0093] When it is read that the blood collection tube 11 is a centrifuged blood collection tube 11 , the first reversing mechanism 104 controls the first outlet and the output port of the second conveying device 102 to be closed, and the blood collection tube 11 continues to be conveyed along the conveying direction of the first conveying device 101 .

[0094] When it is read that the blood collection tube 11 is not centrifuged, the first switching mechanism 104 controls the first outlet and the output port of the second conveying device 102 to be connected, and the blood collection tube 11 enters the second conveying device 102 .

[0095] The reading mechanism 7 can capture information about the entire circumference of the blood collection tube 11. Specifically, multiple cameras 702 can be provided to capture information about the blood collection tube 11 at different angles to determine whether the blood collection tube 11 is a centrifuged blood collection tube 11. It should be noted that only one camera 702 can be provided, and the blood collection tube 11 can be captured at different angles by providing a rotating device 701 to rotate the sample holder 9. That is, the reading mechanism 7 includes a rotating device 701, a camera 702, and a blocking member 703. The blocking member 703 can be retractably installed on one side of the conveying device 1 to block the sample holder 9. Figure 7 As shown, in order to improve the shooting effect, the present invention discloses that the reading mechanism 7 also includes a light source 704 and a plane mirror 705. The light source 704 illuminates the observed surface of the blood collection tube 11 to provide a bright environment for taking pictures. The sample holder 9 and the camera 702 are symmetrically distributed about the central axis of the plane mirror 705, that is, the camera 702 can observe the blood collection tube 11 through the plane mirror 705. The AI ​​visual system is introduced to increase the judgment of the height, diameter, cap, color, and placement of the blood collection tube 11, which is convenient for the automated information processing of the assembly line; scanning by the plane mirror 705 effectively shortens the problem of the general visual scanning device occupying a large track longitudinal space; the light source 704 directly fills the blood collection tube 11 with light and the camera 702 indirectly scans, effectively avoiding the interference of the shadow of the blood collection tube 11 on the information scanning of the blood collection tube 11.

[0096] Further, the present invention discloses a rotating device 701 including a driven wheel 7011 and a driving wheel 7012. The driven wheel 7011 is arranged on one side of the conveying device 1, and the driving wheel 7012 is retractably arranged on the other side of the conveying device 1. When the sample holder 9 needs to be rotated, the driving wheel 7012 extends to press the sample holder 9, and the other side of the sample holder 9 abuts against the driven wheel 7011. The driving wheel 7012 rotates under the drive of a motor, etc., thereby driving the sample holder 9 to rotate. Specifically, there are two driving wheels 7012. When the driving wheel 7012 presses the sample holder 9, the two driving wheels 7012 are respectively located at the front and rear ends of the driven wheel 7011 to form a triangle. The device for driving the driving wheel 7012 to retract can be a gear rack mechanism, an electric push rod structure, etc., or other structures.

[0097] In some embodiments, the online centrifugation system further includes a rotating code scanning mechanism 8, which is located on the side wall of the second conveying device 102 and is used to scan the information of the blood collection tube 11 on the sample tray 9 of the second conveying device 102.

[0098] When the sample tray 9 on the second conveying device 102 does not contain the blood collection tube 11, the rotating code scanning mechanism 8 unbinds the barcode of the blood collection tube 11 on the sample tray 9, and the third commutation mechanism 106 controls the output port of the second conveying device 102 to communicate with the input port of the sample buffer device; when the sample tray 9 on the second conveying device 102 contains the blood collection tube 11, the rotating code scanning mechanism 8 binds the barcode of the blood collection tube 11 to the sample tray 9, and the third commutation mechanism 106 controls the output port of the second conveying device 102 to communicate with the first inlet.

[0099] In some embodiments, as Figure 4 shown, the balancing and weighing mechanism 2 includes a bottom plate 201 and a weighing device 202. At least one weighing hole for placing the weighing device 202 is formed on the bottom plate 201, and the weighing device 202 is used for weighing the adapter 5.

[0100] Further, the present invention discloses that a receiving groove 2011 conforming to the shape of the adapter 5 is formed on the bottom plate 201. The bottom of the receiving groove 2011 is conductively connected to the top end of the weighing hole, and the top end of the weighing device 202 extends into the receiving groove 2011. The setting of the receiving groove 2011 facilitates the positioning of the adapter 5.

[0101] Furthermore, the present invention discloses that the balancing and weighing mechanism 2 further includes a balancing rack 203, which is installed on the bottom plate 201 and is used for placing the balancing tube 13.

[0102] In some embodiments, as Figure 5 shown, the manipulator 3 includes a bracket 301, a pipe gripper 302 and an adapter gripper 303. The pipe gripper 302 and the adapter gripper 303 are respectively slidably mounted on the bracket 301 along the X, Y and Z directions to realize the movement of the spatial positions of the pipe gripper 302 and the adapter gripper 303 in the X, Y and Z directions.

[0103] The pipe gripper 302 is used to grasp the blood collection tube 11 or the balancing tube 13, and the adapter gripper 303 is used to grasp the adapter 5.

[0104] Further, the present invention discloses that the bracket 301 includes an X-axis bracket 3011, a Y-axis bracket 3012 and a Z-axis bracket 3013, the Y-axis bracket 3012 is slidably mounted on the X-axis bracket 3011 along the X direction, the Z-axis bracket 3013 is slidably mounted on the Y-axis bracket 3012 along the Y direction, and the pipe gripper 302 and the adapter gripper 303 are slidably mounted on both sides of the Z-axis bracket 3013 along the Z direction. It should be noted that the movement of the Y-axis bracket 3012 and the Z-axis bracket 3013 can be driven by a motor or the like.

[0105] Furthermore, the present invention discloses that the number of the tube grippers 302 is two, which can realize the simultaneous grasping of two blood collection tubes 11 , thereby improving the grasping efficiency of the blood collection tubes 11 .

[0106] In some embodiments, the online centrifuge system further includes a main control system, an interface control system, and an electronic control system.

[0107] The main control system is respectively connected with the interface control system, the electric control system and the centrifuge 4 by signals.

[0108] The electronic control system is used to control the operation of the conveying device 1, the balancing and weighing of the balancing and weighing mechanism 2, the movement of the manipulator 3, the operation of the sample holder buffer device 6, the movement of the reading mechanism 7 and the movement of the rotating code scanning mechanism 8.

[0109] Specifically, the interface control system displays the current operating status of each component in real time; according to the interface operation, it realizes the control of conveying device 1, robot 3, centrifuge 4 parameter setting and process control, timing, auxiliary routine control, monomer list display and switching, node control and parameter editing and distribution, local IP port and node number setting, etc.

[0110] The sample transmission module includes four functions: sample tray 9 transmission, sample tray 9 buffering, sample tray 9 check-in and check-out, and adapter 5 check-in and check-out. After the conveyor 1 detects the sample tray 9, the sample tray 9 that needs to be centrifuged is transmitted to the sampling line track by reading and reporting the RFID information of the current sample, and by parsing the received routing instructions, the blood collection tube 11 to be centrifuged is placed on the adapter 5 by the manipulator 3. After the sample check-in process is completed, the sample tray 9 is untied and the empty sample tray 9 is transferred to the buffer area. After the sample check-in on the adapter 5 is completed, the centrifuge 4 is controlled to be in place, the adapter 5 is checked into the centrifuge 4 and the centrifugation process is started. When the centrifugation is completed, the adapter 5 is detected from the centrifuge 4 and the empty sample tray 9 is detected in place, and the centrifuged sample is placed on the sample tray 9. Then, the centrifuged sample tray 9 and the empty sample tray 9 are routed and transmitted to the conveyor 1 after barcode scanning and RFID binding reporting.

[0111] It should be noted that the words indicating direction in this article, such as up and down, are all based on Figure 1The setting made in the direction in [[]] is only for the convenience of description and has no other specific meaning.

[0112] In this specification, the various embodiments are described in a progressive manner. Each embodiment focuses on the differences from other embodiments. For the same or similar parts among the various embodiments, reference can be made to each other.

[0113] The above description of the disclosed embodiments enables those skilled in the art to implement or use the present invention. Various modifications to these embodiments will be obvious to those skilled in the art. The general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to these embodiments shown herein, but rather to the broadest scope consistent with the principles and creative features disclosed herein.

[0114] In the description of this specification, the description with reference to terms such as "one embodiment", "example", "specific example", etc. means that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in a suitable manner in any one or more embodiments or examples.

Claims

1. An online centrifugation system, characterized in that, It includes a conveying device, a balancing and weighing mechanism, a manipulator and a centrifuge; The conveying device, the balancing and weighing mechanism and the centrifuge are arranged in sequence; The conveying device is used for conveying a sample tray containing blood collection tubes, the balancing and weighing mechanism is used for weighing an adapter, and the centrifuge is used for centrifuging blood collection tubes; The manipulator is respectively used for grasping the blood collection tube and the adapter to complete the conveyance of the blood collection tube between the adapter and the conveying device, and the conveyance of the adapter between the centrifuge and the balancing and weighing mechanism; An inlet and outlet window is opened on the centrifuge, and the adapter enters and exits the centrifuge through the inlet and outlet window; It further includes a sample tray caching device; The sample tray caching device is used for supplying empty sample trays to the conveying device; The conveying device includes a first conveying device, a second conveying device, a third conveying device, a first reversing mechanism, a second reversing mechanism and a third reversing mechanism; The first conveying device is used for conveying a sample tray containing blood collection tubes, and along the conveying direction of the first conveying device, a first outlet and a first inlet are sequentially opened on the side wall of the first conveying device. The first outlet is conductively connected to the input port of the second conveying device, and the first reversing mechanism is arranged at the intersection of the first outlet and the output port of the second conveying device for controlling the sample tray containing uncentrifuged blood collection tubes to enter the second conveying device; Along the conveying direction of the second conveying device, a second inlet is opened on the side wall of the second conveying device. The second inlet is conductively connected to the output port of the sample tray caching device, and the second reversing mechanism is arranged at the intersection of the second inlet and the output port of the sample tray caching device for controlling an empty sample tray to enter the second conveying device; The output port of the second conveying device is conductively connected to both the input port of the sample tray caching device and the first inlet. The third reversing mechanism is arranged at the intersection of the output port of the second conveying device with the input port of the sample tray caching device and the first inlet for controlling an empty sample tray to enter the sample tray caching device and controlling the sample tray containing centrifuged blood collection tubes to enter the first conveying device.

2. The on-line centrifugation system according to claim 1, characterized in that The sample tray caching device is arranged perpendicular or parallel to the conveying device.

3. The online centrifugation system according to claim 1, characterized in that, The structures of the first reversing mechanism, the second reversing mechanism and the third reversing mechanism are the same, and each includes a driving part and a reversing part; The driving part is used for driving the reversing part to move, and the reversing part guides the sample tray to realize the reversing of the sample tray.

4. The online centrifugation system according to claim 1, characterized in that, It further includes a reading mechanism; The reading mechanism is arranged on the side wall of the first conveying device for reading the centrifugation information of the blood collection tubes on the first conveying device; When it is read that the blood collection tube is a centrifuged blood collection tube, the first reversing mechanism controls the first outlet and the output port of the second conveying device to be cut off, and the blood collection tube continues to be conveyed along the conveying direction of the first conveying device; When it is read that the blood collection tube is an uncentrifuged blood collection tube, the first reversing mechanism controls the first outlet and the output port of the second conveying device to be conductively connected, and the blood collection tube enters the second conveying device.

5. The online centrifugation system according to claim 1, characterized in that, It further includes a rotating code scanning mechanism; The rotating code scanning mechanism is located on the side wall of the second conveying device for scanning the information of the blood collection tubes on the second conveying device; When the sample tray on the second conveying device does not contain a blood collection tube, the rotating code scanning mechanism unbinds the blood collection tube barcode on the sample tray, and the third reversing mechanism controls the output port of the second conveying device to be conductively connected to the input port of the sample caching device; When the sample tray on the second conveying device holds the blood collection tube, the rotary code scanning mechanism binds the barcode of the blood collection tube to the sample tray, and the third commutation mechanism controls the output port of the second conveying device to communicate with the first inlet.

6. The online centrifugation system according to claim 2, wherein The sample tray buffer device includes a steering mechanism, a guide rail, and a plurality of synchronous belts arranged in parallel. The guide rail is arranged on both sides of the synchronous belts for guiding the sample tray. The conveying directions between adjacent synchronous belts are opposite. The steering mechanism is arranged between adjacent synchronous belts for steering the conveyance of the sample trays on adjacent synchronous belts.

7. The online centrifugation system according to claim 6, characterized in that, The steering mechanism includes a steering plate, a roller, and a driving component. The roller is arranged between adjacent synchronous belts, and the driving component is in transmission connection with the roller for driving the roller to rotate. The steering plate is an arc-shaped plate arranged on both sides of the steering plate for guiding the sample tray from one synchronous belt to an adjacent synchronous belt.

8. The online centrifugation system according to claim 1, characterized in that, The balancing and weighing mechanism includes a bottom plate and a weighing device. At least one weighing hole for holding the weighing device is formed in the bottom plate, and the weighing device is used for weighing the adapter.

9. The on-line centrifugal system according to claim 8, wherein A receiving groove conforming to the shape of the adapter is formed in the bottom plate. The bottom of the receiving groove is in conducting connection with the top end of the weighing hole, and the top end of the weighing device extends into the receiving groove.

10. The on-line centrifugation system according to claim 8, wherein, The balancing and weighing mechanism further includes a balancing rack. The balancing rack is installed on the bottom plate for holding the balancing tube.

11. The online centrifugal system according to claim 10, wherein, The manipulator includes a bracket, a tube gripper, and an adapter gripper. Both the tube gripper and the adapter gripper are slidably mounted on the bracket along the X direction, Y direction, and Z direction respectively. The tube gripper is used for gripping the blood collection tube or the balancing tube. The adapter gripper is used for gripping the adapter.

12. The on-line centrifugation system according to claim 11, characterized in that, The bracket includes an X-axis bracket, a Y-axis bracket, and a Z-axis bracket. The Y-axis bracket is slidably mounted on the X-axis bracket along the X direction, the Z-axis bracket is slidably mounted on the Y-axis bracket along the Y direction, and the tube gripper and the adapter gripper are slidably mounted on both sides of the Z-axis bracket along the Z direction respectively.

13. The online centrifugation system according to any one of claims 1-12, characterized in that, It further includes a main control system, an interface control system, and an electric control system. The main control system is respectively in signal connection with the interface control system, the electric control system, and the centrifuge. The electric control system is used for controlling the operation of the conveying device, the balancing and weighing of the balancing and weighing mechanism, the actions of the manipulator, the operation of the sample tray buffer device, the actions of the reading mechanism, and the actions of the rotary code scanning mechanism.

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