Dynamic tear lens

Abstract

Dynamic contact lenses are disclosed that are manufactured with a dynamic portion that extends outward from a peripheral portion. When worn on an eye, the dynamic portion forms a tear lens for correcting vision. The dynamic portion can also be configured to provide a dynamic tear lens that changes power in response to forces exerted by the eyelids. The dynamic portion can be configured to assume a conformal configuration and at least one non-conformal configuration, or can be configured to assume at least two non-conformal configurations. The dynamic contact lenses can be used to correct vision, such as presbyopia.

Description

[0001] This application is a divisional of the Chinese Patent Application No. 201880044475.7 with a filing date of May 01, 2018, entitled “Dynamic Tear Lens”, which corresponds to the PCT Application No. PCT / US2018 / 030502 with a filing date of May 01, 2018, for the invention of “Dynamic Tear Lens”. TECHNICAL FIELD

[0002] The present disclosure relates to a dynamic contact lens having a dynamic portion that has a conformal configuration and at least one non-conformal configuration, or can have at least two non-conformal configurations, when placed on the cornea. The dynamic portion forms a tear lens for correcting vision when worn on the eye. The dynamic portion can also be configured to provide a dynamic tear lens that changes optical power in response to forces exerted on the dynamic contact lens by eyelid and / or gaze movements. The contact lens can be used to correct vision, such as to correct presbyopia, to slow myopia progression, or to correct vision caused by irregularly shaped corneas. BACKGROUND

[0003] Typical vision problems, such as myopia (nearsightedness), hyperopia (farsightedness), and presbyopia (loss of accommodation and subsequent loss of near vision), can be easily corrected using eyeglasses. However, some people prefer contact lenses for correcting vision for reasons such as adapting to an active lifestyle or aesthetic reasons.

[0004] Contact lens wearers who develop presbyopia with age require additional corrective lenses to allow for near, intermediate, and distance vision simultaneously. To address presbyopia, contact lens manufacturers have developed multifocal lenses that focus light from a range of distances simultaneously via several focal regions, and bifocal lenses that contain two focal regions, such as a central region for correcting near vision and a surrounding region for correcting distance vision. The latter lenses are translated relative to the visual axis of the eye to provide near vision and distance vision correction simultaneously depending on the eye gaze angle.

[0005] Translation contact lenses are configured to move (translate) anywhere from 1 mm to 6 mm above the corneal surface, and are therefore much less stable than standard contact lenses that typically have from 0 mm to 1 mm of movement above the cornea. Since translation lenses are designed to move, during the upper eyelid blink, the translation lens moves down above the cornea so that the lower edge of the lens hits on the lower eyelid margin with each blink movement. Such repetitive movement and eyelid contact causes significant user discomfort due to the foreign body sensitivity of the cornea and lower eyelid margin. Furthermore, since there are meibomian gland openings on the lower eyelid margin, the lower eyelid impact can cause repeated trauma and inflammation of these openings, which can cause hyperkeratosis and can cause meibomian gland dysfunction. SUMMARY

[0006] According to the present invention, a dynamic contact lens comprises: a dynamic portion comprising a dynamic back surface and a dynamic front surface opposite the dynamic back surface; a peripheral portion comprising a peripheral back surface, a peripheral front surface opposite the peripheral back surface, and a transition zone coupling the peripheral portion and the dynamic portion; wherein the dynamic portion comprises: a material having a Young's modulus in a range from 0.05 MPa to 10 MPa; and a preformed central SAG (sagittal) height from 10 pm to 300 pm.

[0007] According to the present invention, a dynamic contact lens comprises: a peripheral portion, a dynamic portion coupled to the peripheral portion, wherein the dynamic portion comprises: a conformal configuration configured to provide a first optical power to an eye having a cornea; and at least one non-conformal configuration configured to provide a second optical power to the eye, wherein the second optical power is different from the first optical power.

[0008] According to the present invention, a dynamic contact lens comprises: a peripheral portion comprising a peripheral back surface and a peripheral front surface, wherein the peripheral back surface comprises a peripheral base curvature; and a dynamic portion comprising a dynamic back surface and a dynamic front surface, wherein at least the dynamic back surface is convex from the peripheral base curvature toward the dynamic front surface.

[0009] According to the present invention, a dynamic contact lens comprises: a dynamic portion comprising a dynamic back surface, wherein the dynamic back surface comprises a dynamic base curvature; a peripheral portion coupled to the dynamic portion, wherein the peripheral portion comprises a peripheral back surface; and the peripheral back surface comprises a peripheral base curvature; wherein, in a first configuration, the dynamic base curvature is substantially the same as the peripheral base curvature; and in a second configuration, the dynamic base curvature deviates from the peripheral base curvature.

[0010] According to the present invention, a dynamic contact lens comprises a dynamic portion, wherein the dynamic portion comprises a dynamic back surface; the dynamic back surface comprises a dynamic base curvature; in a first configuration, the dynamic base curvature is substantially the same as a corneal curvature; and in a second configuration, the dynamic base curvature deviates from the corneal curvature.

[0011] According to the present invention, a dynamic contact lens comprises: a peripheral portion, wherein the peripheral portion comprises a peripheral back surface, wherein the peripheral back surface comprises a peripheral base curvature; and a dynamic portion coupled to the peripheral portion, wherein the dynamic portion comprises a central thickness, and a central SAG height relative to the peripheral base curvature; wherein the dynamic portion is configured to assume a first conformation characterized by a first central gap height relative to the peripheral base curvature, and to assume a second conformation characterized by a second central gap height relative to the peripheral base curvature, wherein the first central gap height and the second central gap height are not the same; and the first conformation and the second conformation are quasi-stable.

[0012] According to the present invention, a dynamic contact lens comprises a dynamic portion comprising a back surface, wherein the back surface comprises a dynamic base curvature; in a first conformation, the back surface comprises a first base curvature; and in a second conformation, the back surface comprises a second base curvature.

[0013] According to the present invention, a dynamic contact lens comprises: a dynamic portion, wherein the dynamic portion comprises: at least one first non-conformal conformation configured for providing a first optical power to an eye having a cornea; and at least one second non-conformal conformation configured for providing a second optical power to the eye, wherein the second optical power is different from the first optical power; at least one first mechanism configured for causing a change between the first non-conformal conformation and the at least one second non-conformal conformation; and at least one second mechanism configured for causing a change between the at least one second non-conformal conformation and the at least one first non-conformal conformation.

[0014] According to the present invention, a dynamic contact lens comprises: a first portion comprising a first back surface, a first front surface opposite the first back surface, and a first material, wherein the first back surface comprises a first radius of curvature; and the first material comprises a first Young’s modulus; and a second portion coupled to the first portion, wherein the second portion comprises a second back surface and a second front surface opposite the second back surface, and a second material, wherein the second back surface comprises a second radius of curvature; and the second material comprises a second Young’s modulus; and wherein the first radius of curvature is smaller than the second radius of curvature; and wherein each of the first Young’s modulus and the second Young’s modulus independently ranges from 0.05 MPa to 10 MPa.

[0015] According to the present invention, a dynamic contact lens comprises: a first portion comprising a first back surface, a first front surface opposite the first back surface, and a first material, wherein the first material comprises a first Young's modulus; and a peripheral portion coupled to the first portion, wherein the peripheral portion comprises: a peripheral back surface having a base curvature, and a second material comprising a second Young's modulus; and wherein the first back surface is convex forward from the base curvature of the back surface of the peripheral portion; and wherein each of the first Young's modulus and the second Young's modulus independently ranges from 0.05 MPa to 10 MPa.

[0016] According to the present invention, a method of correcting vision of a patient comprises applying to an eye of a patient in need of correction of vision a dynamic contact lens according to the present invention.

[0017] According to the present invention, a method of treating presbyopia comprises applying to an eye of a patient suffering from presbyopia a dynamic contact lens according to the present invention.

[0018] According to the present invention, a method of correcting vision of a patient comprises applying to an eye of a patient in need of such treatment a dynamic contact lens according to the present invention.

[0019] According to the present invention, a method of treating an eye of a patient following an ophthalmic treatment comprises applying to an eye of a patient in need of such treatment a dynamic contact lens according to the present invention.

[0020] According to the present invention, a method of treating a traumatic wound of the cornea of an eye of a patient comprises applying to an eye of a patient in need of such treatment a dynamic contact lens according to the present invention.

[0021] According to the present invention, a method of protecting an eye of a patient from potential harm comprises applying to an eye of a patient in need of such protection a dynamic contact lens according to the present invention.

[0022] According to the present invention, a method of manufacturing a dynamic contact lens comprises shaping a material to provide a dynamic contact lens comprising: a peripheral portion comprising a peripheral back surface and a peripheral front surface, wherein the peripheral back surface comprises a peripheral base curvature; and a dynamic portion comprising a dynamic back surface and a dynamic front surface, wherein at least the dynamic back surface is convex from the peripheral base curvature toward the dynamic front surface.

[0023] According to the present invention, a method of manufacturing a dynamic contact lens comprises shaping a material to provide a dynamic contact lens comprising: a dynamic portion characterized by a dynamic base curvature; and a peripheral portion coupled to the dynamic portion, wherein the peripheral portion comprises a peripheral base curvature, wherein the dynamic base curvature is different from the peripheral base curvature.

[0024] According to the present application, the dynamic contact lens according to the present application is applied to the cornea. BRIEF DESCRIPTION OF DRAWINGS

[0025] The drawings described herein are for illustrative purposes only. The drawings are not intended to limit the scope of the present disclosure.

[0026] Figure 1A A cross-sectional view of a dynamic contact lens with a cavity for a tear reservoir provided by the present disclosure is shown.

[0027] Figure 1B A cross-sectional view of a dynamic contact lens without a cavity for a tear reservoir provided by the present disclosure is shown.

[0028] Figure 2A A cross-sectional view of a dynamic contact lens with a dynamic portion and with a tear reservoir provided by the present disclosure is shown, wherein the dynamic portion is adjacent to the anterior surface of the cornea, which can be suitable for uncorrected hyperopia.

[0029] Figure 2B A cross-sectional view of a dynamic contact lens with a dynamic portion and with a tear reservoir provided by the present disclosure is shown, wherein the dynamic portion is raised from the cornea, providing space for a tear lens, which can be suitable for corrected myopia.

[0030] Figure 2C A cross-sectional view of a dynamic contact lens with a dynamic portion and without a tear reservoir provided by the present disclosure is shown, wherein the dynamic portion is adjacent to the anterior surface of the cornea, which can be suitable for uncorrected hyperopia.

[0031] Figure 2D A cross-sectional view of a dynamic contact lens with a dynamic portion and without a tear reservoir provided by the present disclosure is shown, wherein the dynamic portion is raised from the cornea, providing space for a tear lens, which can be suitable for corrected myopia.

[0032] Figures 3A-3D An optical coherence tomography (OCT) image of a dynamic contact lens provided by the present disclosure is shown, which has a tear lens, which in turn has a gap height of 0 pm, 43 pm, 84 pm, and 105 pm.

[0033] Figure 4A and Figure 4B A cross-sectional view of a dynamic contact lens with a wedge-shaped tear reservoir provided by the present disclosure is shown. Figure 4A A dynamic contact lens is shown, wherein the dynamic portion is adjacent to the cornea, wherein the posterior surface of the dynamic portion is held against the cornea by capillary forces. Figure 4AA view of a dynamic contact lens is shown, illustrating the direction of tear movement from the tear reservoir toward the dynamic portion when the lower eyelid exerts force on the tear reservoir when looking downward. Figure 4A A view of a dynamic contact lens is shown, where the dynamic portion is raised from the cornea, providing volume for the tear lens. Figure 4B A view of a dynamic contact lens is shown. Figure 4A A bottom view of a dynamic contact lens is shown.

[0034] Figure 5A A view of a dynamic contact lens is shown. Figure 5B Cross-sectional and bottom views of a dynamic contact lens are shown, respectively, having separate tear cavities in the posterior surface of the peripheral portion symmetrically disposed around a central dynamic portion.

[0035] Figure 6 Three (3) cross-sectional views of a dynamic contact lens provided by the present disclosure are shown.

[0036] Figure 7 A cross-sectional view of a dynamic contact lens is shown, which is used to calculate the relationship between the dome height and the optical power of the tear lens.

[0037] Figure 8 A cross-sectional view of a dynamic contact lens having a near-peripheral tear reservoir is shown.

[0038] Figures 9A-9C An OCT image of a dynamic contact lens provided by the present disclosure, having a dynamic portion and a tear reservoir, applied to a cornea is shown.

[0039] Figure 10 A cross-sectional view of a dynamic contact lens having a near-central dynamic portion provided by the present disclosure is shown.

[0040] Figure 11 A photograph of a dynamic contact lens provided by the present disclosure, on a test-bed model of an eyeball and eyelids, where no eyelid pressure is applied over the peripheral portion is shown.

[0041] Figure 12 A photograph of a model of Figure 11 , where eyelid pressure is applied over the peripheral portion is shown.

[0042] Figure 13 A photograph of a model of Figure 11 and Figure 12 , where the eyelid pressure is released is shown.

[0043] Figure 14A An OCT image of a dynamic contact lens provided by the present disclosure, in a conformal configuration is shown.

[0044] Figure 14BOCT images of a dynamic contact lens in a non-conformal configuration are shown as provided by the present disclosure.

[0045] Figure 15 OCT images of a dynamic contact lens in a non-conformal configuration are shown as provided by the present disclosure.

[0046] Figure 16 OCT images of a dynamic contact lens in a non-conformal configuration are shown as provided by the present disclosure.

[0047] Figure 17A OCT images of a dynamic contact lens in a non-conformal configuration are shown as provided by the present disclosure.

[0048] Figure 17B Images of an eye corresponding to OCT images of Figure 17A

[0049] Figures 18-20 Different cavity configurations for providing a tear reservoir are shown.

[0050] Figure 21 OCT images of an example of a dynamic contact lens forming a negative tear lens are shown as provided by the present disclosure.

[0051] Figure 22 OCT images of a dynamic contact lens forming a negative tear lens are shown as provided by the present disclosure.

[0052] Figures 23A-23C Views of a dynamic contact lens having ridges symmetrically disposed about a dynamic central portion on the anterior surface are shown. Figure 23A Cross-sectional views are shown, Figure 23B Views of the anterior surface are shown, while Figure 23C Views of the posterior surface are shown.

[0053] Figures 24A-24C Views of a dynamic contact lens having ridges symmetrically disposed about a dynamic central portion on the anterior surface and overlying overlapping reservoirs in the posterior surface are shown. Figure 24A Cross-sectional views are shown, Figure 24B Views of the anterior surface are shown, while Figure 24C Views of the posterior surface are shown.

[0054] Figure 25A Graphs of the gap height between the posterior surface of the dynamic central portion and the cornea relative to the gap height of the dynamic central portion of a preformed dynamic contact lens are shown.

[0055] Figure 25B ​OCT image of a dynamic contact lens with a 40 pm preformed SAG height, exhibiting a tear lens within a 37 pm gap height when placed on an eye.

[0056] Figure 25C OCT image of a dynamic contact lens with a 100 pm preformed SAG height, exhibiting a tear lens within a 96 pm gap height when placed on an eye.

[0057] Figures 26A-26C Graph of the gap height between the back surface of the dynamic central portion and the cornea versus the SAG height of the dynamic central portion of a preformed dynamic contact lens for different thicknesses of the dynamic central portion.

[0058] Figure 27 Cross-section of a portion of a dynamic contact lens with a fluid reservoir and a ridge covering the fluid reservoir is shown.

[0059] Figure 28 Photograph of (1) a dynamic lens with a glued ridge on an eye (top left), and (2) a schematic cross-section of a portion of a dynamic contact lens with a ridge on the front surface of the dynamic contact lens (bottom right) is shown.

[0060] Figure 29 OCT image of a cross-section of a dynamic contact lens with a ridge on the cornea in a primary (forward) gaze case is shown.

[0061] Figure 30 OCT image of a cross-section of a dynamic contact lens with a ridge on the cornea in a downward gaze case is shown.

[0062] Figure 31 OCT image of a dynamic contact lens with a preformed ridge on the cornea of about 500 microns width during downward gaze, and a gap height of 38 microns is shown.

[0063] Figure 32 OCT image of a dynamic contact lens with a flat peripheral profile with an 11 mm base curve covering the cornea is shown.

[0064] Figures 33A-41B Cross-sectional view of an example of a dynamic contact lens provided by the present disclosure in a conformal and a non-conformal configuration, and a less non-conformal configuration and a more non-conformal configuration is shown.

[0065] Reference will now be made in detail to certain embodiments of the disclosure. While certain embodiments of the disclosure will be described, it will be understood that the embodiments of the disclosure are not intended to limit the embodiments of the disclosure to the disclosed embodiments. On the contrary, the embodiments of the disclosure are intended to cover alternatives, modifications, and equivalents, which can be included within the spirit and scope of the embodiments of the disclosure as defined by the appended claims. DETAILED DESCRIPTION

[0066] As used herein, "posterior" describes features facing the eye when worn by a patient, while "anterior" describes features facing away from the eye. The posterior surface of a dynamic contact lens or portion thereof refers to the surface that is proximal to or facing the cornea during patient wear. The anterior surface of a dynamic contact lens or portion thereof refers to the surface that is distal to or facing away from the cornea during patient wear.

[0067] "Substantially" means, for example, ±10% of a value.

[0068] "Substantially conformal to the surface of the cornea" refers to a configuration in which the posterior surface of a portion of a dynamic contact lens is within 3 pm from the surface of the cornea. The gap between the posterior portion of the dynamic contact lens and the cornea can contain tear fluid.

[0069] As used herein, the "modulus" of a material refers to the Young's modulus. The Young's modulus can be determined, for example, according to the method described by Jones et al., Optometry and Vision Science, 89, 10, 1466-1476, 2017.

[0070] The optical power of a cornea, expressed in diopters (D), can be related to the radius of curvature R by the formula D = (1.3375 - 1) / R, where 1.3375 corresponds to the refractive index of the aqueous humor and R corresponds to the radius of curvature of the anterior surface of the cornea. The curvature of the cornea is inversely proportional to the radius of curvature R, such that as the radius of curvature increases, the curvature of the cornea decreases, and such that as the radius of curvature decreases, the curvature of the cornea increases.

[0071] While rigid gas permeable (RGP) lenses are known to create a tear lens, RGP lenses do not possess the ability to change shape. Soft dynamic contact lenses generally conform to the corneal surface in a uniform manner, and any thin tear film under the lens is not utilized and insufficient to create any optical power. In the present invention, a dynamic tear lens system is used in conjunction with soft contact lens materials.

[0072] The dynamic contact lenses provided by the present disclosure can be manufactured to have a dynamic portion that can transition between two or more configurations on the eye, where each of the two or more configurations provides a different optical power. When in a configuration where the dynamic portion or at least a portion of the dynamic portion is not conformal with the cornea, a lens-like volume is formed between the anterior surface of the cornea and the posterior surface of the dynamic portion of the dynamic contact lens, which can be filled with tear fluid to form a tear lens for correcting vision. The dynamic contact lens can be configured to transition between a conformal configuration and one or more non-conformal configurations. The dynamic lens can be configured to transition between two or more non-conformal configurations.

[0073] The dynamic contact lenses provided by the present disclosure can be manufactured to have a dynamic portion that can transition between two or more configurations on the eye, where each of the two or more configurations provides a different optical power. When in a configuration where the dynamic portion or at least a portion of the dynamic portion is not conformal with the cornea, a lens-like volume is formed between the anterior surface of the cornea and the posterior surface of the dynamic portion of the dynamic contact lens, which can be filled with tear fluid to form a tear lens for correcting vision. In such cases, the at least two configurations are both non-conformal and each have a tear lens, each tear lens providing a different optical power to the eye.

[0074] A tear lens is a liquid lens formed between the posterior surface of the dynamic contact lens and the anterior corneal surface. The tear lens, in combination with other optical surfaces in the system, such as the cornea and the dynamic contact lens, forms a new optical system. The quantitative relationship between the base curve of the dynamic contact lens and the tear lens power can be described by equation (1):

[0075] Power of tear lens = (336 / R BOZ – 336 / K) (1)

[0076] where R BOZ is the back optic zone radius of the dynamic contact lens in mm; and K is the radius of the anterior surface of the cornea in mm. The base curve refers to the curvature of the posterior surface of the peripheral portion of the dynamic contact lens and is substantially the same as the curvature of the anterior surface of the cornea when seated on the cornea.

[0077] The quantitative relationship between the actual posterior surface base curve of the dynamic contact lens and the tear lens can also be described by equation (2):

[0078] F t = (n-1) / R BOZ + (1-n) / RC (2)

[0079] where F tis the power of the tear lens; n is the refractive index of the tear fluid (1.337 ± 0.001); RC is the radius of curvature of the cornea in mm; and R BOZ is the back optic zone radius of the dynamic contact lens in mm.

[0080] For a cylindrical tear lens, the quantitative relationship is calculated for each meridian.

[0081] A cross-section of an example of a dynamic contact lens 100 provided by the present disclosure is shown in Figure 1A The lens includes a dynamic portion 101 that is convex from the base curvature of the peripheral portion 102 and / or from the base curvature of the peripheral portion adjacent to the dynamic portion. This region of the peripheral portion can be referred to as the para-central peripheral portion adjacent to the dynamic portion. The para-central peripheral has a base curvature. The dynamic portion is convex from the base curvature of the para-central peripheral portion in the preformed non-conformal configuration. It should be understood that 102 represents a different curvature than 101 and can itself be formed by one or more curvatures. The dynamic portion 101 includes a dynamic anterior surface 103 and a dynamic posterior surface 104. The dynamic posterior surface 104 includes a curvature. The peripheral portion 102 of the dynamic contact lens includes a peripheral anterior surface 105, a peripheral posterior surface 106, a peripheral edge 107, and a lens diameter 116. The peripheral portion 102 is coupled to the dynamic portion 101. The dynamic portion 101 is coupled to the peripheral portion 102 at an interface 108, also referred to as a transition zone. The peripheral posterior surface includes a cavity 109 that is filled with tear fluid when placed on the cornea to provide a tear reservoir. The peripheral posterior surface 106 includes a peripheral base curvature. The extension of the peripheral base curvature below the area of the dynamic portion 101 is indicated by the dashed line. A SAG height 110 is shown as the distance from the peripheral base curvature to the lens posterior surface. As used herein, SAG height refers to one dimension of a preformed dynamic lens and can be referred to as a preformed SAG height. When applied to the cornea, the distance between the posterior surface of the dynamic portion and the cornea is referred to as the gap height. As disclosed herein, the gap height can be the same as the SAG height, however, in many embodiments, the gap height is less than the preformed SAG height. At some gaze angles, the gap height can be less than the preformed SAG height and at other gaze angles, the gap height can be close to the preformed SAG height. The central convexity includes a plurality of SAG heights that depend on the radial distance from the center of the lens. In Figure 1A In the preformed non-conformal configuration, the maximum SAG height is at the center of the dynamic portion, which is at the center geometric axis 112 of the lens. The SAG height decreases toward the periphery 115 of the dynamic portion, thereby forming the lens shape. In Figure 1AIn some embodiments, the optical zone 111 is slightly larger than the diameter of the dynamic portion. The optical zone refers to the area of the lens used for vision. The diameter of the dynamic portion can be larger than the diameter of the optical zone. In some embodiments, the diameter of the dynamic portion can be smaller than the diameter of the optical zone. In some embodiments, the diameter of the dynamic portion can be similar or the same as the diameter of the optical zone.

[0082] As shown in Figure 1A The central SAG height 110 is defined as the distance between the extended curvature of the peripheral back surface 106 configured to rest on the cornea and the back surface 104 at the center of the dynamic portion, as shown in The dynamic portion can be characterized by a plurality of SAG heights depending on the position of the central axis of the relatively convex dynamic portion. The SAG height will be greatest at the center and will decrease toward the periphery of the dynamic portion. The dynamic portion 101 includes a central thickness 112, and two examples of radial sagittal thickness are identified as 113a and 113b. In Figure 1A In some embodiments, the diameter of the optical zone 111 is shown as slightly larger than the diameter of the dynamic portion 115. The dynamic contact lens 100 has a diameter 116. As shown in Figure 1A As shown in

[0083] Figure 1B A dynamic contact lens similar to the dynamic contact lens shown in Figure 1A is shown, but without a cavity for a tear reservoir. Figure 1B The definitions of the elements in Figure 1A .

[0084] A dynamic contact lens provided by the present disclosure can include a peripheral portion comprising a peripheral posterior surface and a peripheral anterior surface opposite the peripheral posterior surface; a dynamic portion; a transition zone coupling the peripheral portion and the dynamic portion; wherein the dynamic portion comprises: a material having a Young's modulus ranging from 0.05 MPa to 50 MPa; and wherein the dynamic portion is characterized by a profile extending away from the peripheral anterior surface and away from the peripheral posterior surface. The dynamic portion can be characterized by a preformed SAG height ranging from 10 pm to 250 pm. The Young's modulus, for example, ranges from 0.1 MPa to 20 MPa, from 0.1 MPa to 3 MPa, from 0.1 MPa to 2 MPa, or from 0.1 MPa to 5 MPa. The dynamic portion can be characterized by a preformed SAG height ranging from 10 pm to 100 pm. The dynamic portion can include a maximum thickness ranging from 20 pm to 600 pm, from 50 pm to 500 pm, from 100 pm to 400 pm, or from 50 pm to 300 pm. The dynamic portion can include a central thickness ranging from 20 pm to 600 pm, from 50 pm to 500 pm, from 100 pm to 400 pm, or from 50 pm to 300 pm. The dynamic portion is characterized by a substantially uniform thickness, a central thickness that is the same as the thickness at the transition zone, a central thickness that is greater than the thickness at the transition zone, or a central thickness that is less than the thickness at the transition zone. The peripheral portion can include an intermediate portion coupled to the dynamic portion, the intermediate portion characterized by an intermediate radius of curvature; and a distal portion coupled to the intermediate portion, the distal portion characterized by a distal radius of curvature, wherein the intermediate radius of curvature is less than the distal radius of curvature. The transition zone can include one or more features configured to facilitate the dynamic portion transitioning between two or more quasi-stable configurations. The dynamic contact lens can include one or more cavities in the peripheral posterior surface. The dynamic contact lens can include one or more protrusions in the peripheral anterior surface. The dynamic contact lens can include one or more grooves in the posterior surface of the peripheral portion. The dynamic contact lens can include one or more fenestrations. The dynamic contact lens can include one or more cavities in the peripheral posterior surface and one or more protrusions in the peripheral anterior surface, one or more grooves in the posterior surface, and / or one or more fenestrations. The grooves or channels can be coupled to the one or more fenestrations.

[0085] A dynamic contact lens provided by the present disclosure can include a dynamic portion including a dynamic back surface and a dynamic front surface opposite the dynamic back surface; a peripheral portion including a peripheral back surface, a peripheral front surface opposite the peripheral back surface, and a transition zone coupling the peripheral portion and the dynamic portion; wherein the dynamic portion includes: a material having a Young's modulus ranging from 0.05 MPa to 10 MPa; and a preformed central SAG height ranging from 10 pm to 300 pm.

[0086] The material may, for example, have a Young's modulus ranging from 0.05 MPa to 8 MPa, from 0.1 MPa to 6 MPa, from 0.1 MPa to 4 MPa, from 0.1 MPa to 3 MPa, from 0.1 MPa to 2 MPa, or from 0.5 MPa to 1 MPa.

[0087] The central SAG height, such as the central preformed SAG height, may, for example, range from 20 pm to 300 pm, from 50 pm to 300 pm, from 10 pm to 200 pm, from 10 pm to 100 pm, from 50 pm to 250 pm, or from 50 pm to 200 pm.

[0088] The dynamic contact lens can be configured to produce a tear lens for correcting vision when applied to the cornea.

[0089] The dynamic portion can assume two or more quasi-stable configurations when the dynamic contact lens is applied to the cornea, wherein the two or more quasi-stable configurations are characterized by different gaps between the central dynamic back surface and the cornea. The dynamic contact lens can be configured such that the dynamic portion can transition between the two or more quasi-stable states by pressure applied to the dynamic contact lens by the eyelid.

[0090] The dynamic portion can have a diameter of, for example, from 2.5 mm to 7 mm, from 2.5 mm to 6.5 mm, from 2.5 mm to 6.0 mm, from 2.5 mm to 5 mm, or from 2 mm to 4 mm.

[0091] The dynamic back surface can have a radius of curvature of, for example, from 3 mm to 7.5 mm, from 3 mm to 7 mm, from 3.5 mm to 6.5 mm, or from 4 mm to 6 mm.

[0092] The dynamic back surface of the dynamic contact lens can have a substantially spherical curvature, and the dynamic front surface can have a substantially spherical curvature. Thus, in certain embodiments, the power of the dynamic lens is derived from the tear lens rather than from the material forming the lens.

[0093] The dynamic portion can have a substantially uniform thickness. For example, the dynamic portion can have a substantially uniform thickness from 20 pm to 300 pm, from 20 pm to 250 pm, from 50 pm to 200 pm, or from 50 pm to 150 pm.

[0094] The dynamic portion can have a non-uniform thickness. For example, the dynamic portion having a non-uniform thickness can have a central thickness from 20 pm to 300 pm, from 20 pm to 250 pm, from 50 pm to 200 pm, or from 50 pm to 150 pm.

[0095] The transition zone can be configured to facilitate tear flow to a tear lens formed between the dynamic posterior surface and the cornea when the dynamic mirror is applied to the eye.

[0096] For example, the transition zone can include a groove or channel that facilitates the ability of tears to flow into and out of the tear lens defined by the dynamic portion.

[0097] The one or more channels can be disposed in the posterior surface of the peripheral portion and can extend from the dynamic portion to the peripheral portion.

[0098] For example, each of the one or more channels can extend radially outward from the dynamic portion.

[0099] The one or more channels may, for example, include from 3 to 20 channels, from 3 to 16 channels, from 3 to 12 channels, from 4 to 10 channels, or from 4 to 8 channels.

[0100] Each of the one or more channels may, for example, have a width from 100 pm to 1000 pm, from 100 pm to 800 pm, from 100 pm to 600 pm, from 200 pm to 600 pm, or from 400 pm to 600 pm.

[0101] Each of the one or more channels may, for example, have a height / depth from 50 pm to 200 pm, from 50 pm to 150 pm, or from 100 pm to 200 pm.

[0102] Each of the one or more channels may, for example, have a length from 1 mm to 7 mm, from 1 mm to 6 mm, from 1 mm to 5 mm, from 1 mm to 4 mm, or from 1 mm to 3 mm.

[0103] The groove or channel can have any appropriate cross-sectional profile to facilitate the flow of tears.

[0104] At least one of the channels can be coupled to one or more fenestrations extending through the peripheral anterior surface. The fenestrations can be configured to fluidly couple the tear layer or anterior surface of the lens to the channels or to the tear film between the peripheral posterior surface of the lens and the cornea. For example, the channels can be coupled to one, two, three, or more fenestrations.

[0105] Each of the one or more fenestrations can independently have a diameter of, for example, from 200 pm to 600 pm, from 300 pm to 500 pm. The fenestrations can have any appropriate cross-sectional profile to facilitate the flow of tear fluid.

[0106] The transition zone can include features configured to enhance the flexibility of the dynamic portion. Examples of features to enhance the flexibility of the dynamic portion, to facilitate the ability of the dynamic portion to transition between quasi-stable configurations, and / or to facilitate the ability of the dynamic portion to maintain a quasi-stable configuration include a smooth edge, a thinned cross-sectional thickness, a groove, or a combination of any of the foregoing.

[0107] For example, a dynamic contact lens provided by the present disclosure can include a dynamic portion having a diameter of from 2.5 mm to 7 mm; a posterior dynamic surface having a radius of curvature of from 3 mm to 7.5 mm; a substantially uniform thickness having a central thickness of from 20 pm to 300 pm; one or more channels extending radially outward from the dynamic portion toward a peripheral edge of the lens, wherein the one or more channels are from 3 to 20 channels, wherein each channel has a width of from 100 pm to 1000 pm, a height / depth of from 50 pm to 200 pm, a length of from 1 mm to 7 mm; and one or more fenestrations coupled to each of the one or more channels, wherein the fenestrations have a diameter of from 200 pm to 600 pm.

[0108] As another example, a dynamic contact lens provided by the present disclosure can include a dynamic portion having a diameter of from 2.5 mm to 7 mm; a posterior dynamic surface having a radius of curvature of from 3 mm to 7.5 mm; a substantially uniform thickness having a central thickness of from 50 pm to 300 pm; one or more channels extending radially outward from the dynamic portion toward a peripheral edge of the lens, wherein the one or more channels are from 3 to 10 channels, wherein each channel has a width of from 400 pm to 600 pm, a height / depth of from 50 pm to 150 pm, a length of from 1 mm to 5 mm; and one or more fenestrations coupled to each of the one or more channels, wherein the fenestrations have a diameter of from 300 pm to 500 pm.

[0109] A dynamic contact lens provided by the present disclosure can include a dynamic portion, wherein the dynamic portion includes a conformal configuration configured to provide a first optical power to an eye having a cornea; and at least one non-conformal configuration configured to provide a second optical power to the eye, wherein the second optical power is different than the first optical power; at least one first feature configured to induce a change between the conformal configuration and the at least one non-conformal configuration; and at least one second mechanism configured to induce a change between the at least one non-conformal configuration and the conformal configuration.

[0110] A dynamic contact lens provided by the present disclosure can include a dynamic portion, wherein the dynamic portion includes a first non-conformal configuration configured to provide a first optical power to an eye having a cornea; and at least one second non-conformal configuration configured to provide a second optical power to the eye, wherein the second optical power is different than the first optical power; at least one first feature configured to induce a change between the first non-conformal configuration and the at least one second non-conformal configuration; and at least one second mechanism configured to induce a change between the at least one non-conformal configuration and the conformal configuration.

[0111] When applied to the eye, the dynamic portion can assume a configuration in which the back surface of the dynamic portion is conformal or substantially conformal to the front surface of the cornea. It will be appreciated that under the conformal configuration, there will be a thin tear film between the back surface of the dynamic contact lens and the front surface of the cornea. For example, the tear film can be from 0.1 pm to 3 pm thick, from 0.5 pm to 2.5 pm thick, or from 1 pm to 2 pm thick. The dynamic contact lens can be designed such that under the conformal configuration, the tear film thickness between the dynamic portion and the cornea can be greater than 3 pm and / or can vary across the dynamic portion to produce a lens shape.

[0112] When applied to the eye, the dynamic portion can assume a first non-conformal configuration in which the posterior surface of the dynamic portion does not conform to the anterior surface of the cornea. For example, under the first non-conformal configuration, the central gap between the anterior surface of the cornea and the posterior surface of the dynamic portion can be greater than 3 pm, such as greater than 5 pm, greater than 10 pm, greater than 20 pm, greater than 30 pm, greater than 40 pm, greater than 50 pm, greater than 60 pm, greater than 70 pm, greater than 80 pm, or greater than 100 pm. For example, under the first non-conformal configuration, the central gap between the anterior surface of the cornea and the posterior surface of the dynamic portion can be in a range from 5 pm to 100 pm, from 10 pm to 90 pm, from 10 pm to 70 pm, from 10 pm to 50 pm, or from 10 pm to 30 pm. The dynamic portion can assume a second conformal configuration in which the central gap between the anterior surface of the cornea and the posterior surface of the dynamic portion is greater than the central gap under the first non-conformal configuration, and can be, for example, in a range from 10 pm to 200 pm or from 10 pm to 100 pm. It will be appreciated that the fundamental difference between these two configurations is that one configuration conforms more to the cornea and the other configuration conforms less, and thus a change in the size of the tear lens between the two non-conformal configurations, which provides a change in optical power when the dynamic mirror is in one of the two quasi-stable non-conformal configurations.

[0113] The dynamic mirror is fabricated such that the curvature 101 is different from the curvature 102, such that the preformed SAG height is small when there is no tear flow under the dynamic portion and no mechanical force applied to the lens. However, when tear fluid flows under the dynamic portion, for example caused by gaze change or eyelid pressure, the preformed SAG assumes a portion or all of the preformed SAG height, resulting in a change in the size of the tear lens, and thus a change in the optical power of the dynamic portion. The preformed SAG can be designed based on the desired change in optical power.

[0114] The gap height of the tear lens can assume 10% to 100% of the preformed SAG height during gaze changes or under eyelid pressure. The percentage by which the gap height can recover depends at least in part on the flow of tear fluid, the availability of tear fluid to flow under the dynamic portion, and structural features such as tear reservoirs, channels, grooves, fenestrations, transition geometries, peripheral and edge geometries, and / or other features such as material properties and surface properties that control and / or facilitate tear flow in different portions of the dynamic mirror. In effect, the preformed SAG height and other structural features of the dynamic mirror, including for example thickness, material modulus, radius of curvature, and diameter, contribute to a restoring force to the dynamic portion in a forward direction and away from the cornea, which restoring force creates a suction force to pull tear fluid under the dynamic portion to form a tear lens under the quasi-stable non-conformal configuration. This restoring force can be overcome by applying eyelid pressure to the dynamic mirror, causing the dynamic portion to move in a backward direction and toward the cornea to assume another quasi-stable non-conformal or conformal configuration.

[0115] In a conformal configuration, the distance between the back surface of the dynamic portion and the cornea can be, for example, less than 3 pm, less than 2 pm, or less than 1 pm.

[0116] The dynamic contact lens can be manufactured such that the dynamic portion is designed to not conform to the cornea. In such embodiments, the dynamic portion arches over the cornea, creating a gap height equal to or greater than 10 pm to create a tear lens that provides optical power. For example, a 3 mm optic with a base curve of 6.2 mm would create a gap height of 40 pm relative to a paracentral base curve; or, for example, a 5 mm optic with a base curve (BC) of 6.4 mm would create a gap height of 100 pm relative to a paracentral BC. In a conformal configuration, the base curvature of the back surface of the dynamic portion can be substantially the same as the base curvature of the peripheral portion.

[0117] In another embodiment, the contact lens is designed such that the dynamic portion is made of a low modulus material disclosed herein, for example, a material having a Young’s modulus from 0.05 MPa to 10 MPa or from 0.1 MPa to 2 MPa, designed to not conform to the cornea. In such embodiments, the dynamic portion arches over the curvature of the cornea to create a gap equal to or greater than 10 pm to create a tear lens. For example, a 3 mm optic with a BC of 6.2 mm would create a gap height of 40 pm relative to a paracentral BC; or, for example, a 5 mm optic with a BC of 6.4 mm would create a gap height of 100 pm relative to a paracentral BC. In a conformal configuration, the base curvature of the back surface of the dynamic portion can be substantially the same as the base curvature of the peripheral portion.

[0118] The conformal configuration represents a quasi-stable state. Quasi-stable refers to the configuration that can be maintained for a period of time unless or until a force is applied to disrupt the quasi-stable equilibrium.

[0119] The quasi-stable conformal configuration can be maintained by adhesive forces between the back surface of the dynamic portion and the anterior surface of the cornea. The quasi-stable conformal configuration can be maintained by the mechanical dynamics of the dynamic contact lens. The quasi-stable conformal configuration can be maintained by a combination of adhesive forces and lens mechanical forces.

[0120] The adhesive forces can be mediated by capillary forces, for example, including cohesive forces within the tear fluid and adhesive forces between the tear film and the anterior surface of the cornea. The surface tension of the tear film between the back surface of the dynamic portion and the cornea can cause the two surfaces to adhere. Since the tear fluid and the anterior ocular surface are hydrophilic, the adhesive forces will be favored when the back surface of the dynamic portion is also hydrophilic. Conversely, when the dynamic back surface is hydrophobic, the adhesive forces will be less.

[0121] Mechanical force may come from the choice of thickness in certain areas of the lens, the choice of curvature in certain areas of the lens, and the incorporation of features that facilitate manipulation of the lens through the eyelids.

[0122] In a conformal configuration, the adhesive force can extend across the entire dynamic back surface, or it can extend over a portion of the dynamic back surface.

[0123] In a conformal configuration, the gap between the dynamic posterior surface and the cornea has a substantially uniform diameter across the dynamic portion. The gap difference can be defined as the difference between the gap distance at the center of the dynamic portion and the gap distance at a radial distance from the center. In a conformal configuration, the gap difference is smaller and at its minimum. The gap difference in a conformal configuration is smaller than that in a non-conformal configuration.

[0124] In a conformal configuration, the dynamic portion can be configured to provide a first optical power to the eye. The first optical power can be zero (0D). The optical power can, for example, be in the range of 0D to ±6D, 0D to ±4D, 0D to ±3D, 0D to ±2D, or 0D to ±1D.

[0125] The dynamic part can have one or more quasi-stable nonconformal configurations.

[0126] One or more nonconformal configurations may include a single nonconformal configuration, two or more discrete nonconformal configurations, or multiple quasi-stable nonconformal configurations that may be continuous or discrete.

[0127] In a conformal configuration, the gap difference between the posterior surface of the lens and the cornea is smaller at the center of the dynamic portion and at the periphery of the dynamic portion towards the transition zone with the peripheral portion than in a non-conformal configuration.

[0128] In a non-conformal configuration, the dynamic portion does not adhere to the cornea. The dynamic portion extends above or protrudes from the surface of the cornea to provide a lenticular volume between the posterior surface of the dynamic portion and the cornea. This lenticular volume can be filled with tear fluid to form a tear lenticule.

[0129] The non-conformal configuration of the dynamic contact lens, when positioned on the eye, provides a second optical power to the eye along with the tear lens, where the first optical power (under the conformal configuration) is not the same as the second optical power. The second optical power under the non-conformal configuration can be greater than or less than the optical power under the conformal configuration. For example, the second optical power can be less than the first optical power by ±1D, ±2D, ±3D, ±4D, ±5D, or ±16D. For example, the second optical power can be from 0.1D to 6D, from 0.1D to 5D, from 0.1D to 4D, from 0.1D to 3D, from 0.1D to 2D, or from 0.1D to 1D of the first optical power. For example, the second optical power can be from -0.1D to -6D, from -0.1D to -5D, from -0.1D to -4D, from -0.1D to -3D, from -0.1D to -2D, or from -0.1D to -1D of the first optical power.

[0130] In certain dynamic contact lenses, the first optical power does not provide a change in optical power to the eye; and in certain dynamic contact lenses, the second optical power does not provide a change in optical power to the eye.

[0131] In certain dynamic contact lenses, the conformal configuration provides a first change in optical power to the eye; and at least one non-conformal configuration provides a second change in optical power to the eye in addition to the first change in optical power.

[0132] For a single non-conformal configuration, the dynamic portion can assume a single configuration, where the dynamic central portion does not adhere to the cornea. The single non-conformal configuration can be quasi-stable. The single non-conformal configuration can have substantially the same shape as the preformed dynamic portion.

[0133] The non-conformal configuration can include two or more discrete configurations. Each of the two or more discrete non-conformal configurations can impart a different optical power to the eye. The different optical powers result from different optical powers of the tear lens formed by the dynamic portion. Each of the two or more discrete configurations can be quasi-stable.

[0134] The non-conformal configuration can include a plurality of configurations that can be discrete or continuous. The discrete or continuous configurations can be quasi-stable or can be unstable. One or more of the plurality of discrete or continuous configurations can be quasi-stable. For example, a quasi-stable configuration contained in a plurality of continuous configurations can substantially include the shape of the preformed dynamic portion.

[0135] The non-conformal configuration can be characterized by a central gap relative to a base curvature of the peripheral portion. The posterior surface of the peripheral portion can be characterized by a single curvature, which as Figure 1A and Figure 1BAs shown in FIG. 1, the peripheral base curvature can extend under the dynamic portion of the dynamic contact lens. In the non-conformal configuration, the distance between the posterior surface of the dynamic portion and the peripheral base curvature is a gap height relative to the peripheral base curvature. In the non-conformal configuration, the gap height can decrease radially from the center of the dynamic portion toward the periphery of the dynamic portion.

[0136] In certain designs, such as for negative tear lenses, the pre-fabricated SAG height and gap height can increase toward the transition between the dynamic portion and the peripheral portion and then decrease.

[0137] The anterior surface of the lens can have a multi-focal structure, such as so that when the dynamic portion assumes the non-conformal configuration to provide additional optical power to the eye, the region of the dynamic portion periphery provides the same optical power as in the conformal configuration.

[0138] The entire dynamic lens configuration can be coupled with a multi-focal lens design to provide the benefits of a multi-focal lens while also providing additional optical power from the dynamic lens under the desired conditions, such as for intermediate and near vision.

[0139] When placed on the eye, the peripheral portion can conform to the cornea, and the peripheral base curvature can be substantially the same as the corneal curvature, and the gap height can be referenced to the anterior surface of the cornea.

[0140] In the non-conformal configuration, the central gap height of the dynamic portion can be greater than the central gap height in the conformal configuration.

[0141] In the non-conformal configuration, the gap height difference will be greater than the gap height difference in the conformal configuration.

[0142] The dynamic contact lens provided by the present disclosure can include one or more features configured to cause a change in the configuration of the dynamic portion.

[0143] The one or more features can cause a change in the configuration when the eyelid exerts pressure on the feature. The mechanism for exerting the eyelid pressure can be passive, active, or a combination thereof. Passive mechanisms can include, but are not require, conscious action by the wearer of the dynamic contact lens. For example, a passive mechanism can include changing the angle of gaze. Active mechanisms can involve conscious action by the wearer of the dynamic contact lens to cause a transition from one configuration to another. Examples of active mechanisms include consciously blinking or consciously squinting to cause a transition from one configuration of the dynamic portion to another configuration of the dynamic portion. Conscious mechanisms can include repeated blinking or keeping the eyelids closed for a period of time.

[0144] The mechanism for causing a change in configuration can also be due to internal forces within the lens that, once overcome by the capillary forces, can cause the dynamic portion to protrude. For example, for a lens manufactured with a protrusion, the protrusion configuration can represent a low energy configuration. Upon reduction of the capillary forces to release the conformal dynamic portion, the physical structure of the dynamic contact lens will act as a force to cause the dynamic portion to protrude from the cornea and assume the preformed shape. The mechanism for causing the transition between the conformal state and the non-conformal state can not involve capillary forces. Mechanical forces within the lens can cause the dynamic portion to transition between configurations. During or after the dynamic lens has transitioned between configurations, e.g., from the conformal configuration to the non-conformal configuration, tear fluid can flow into the volume between the back surface of the dynamic contact lens and the cornea to form a tear lens. The mechanical forces can be from the choice of design of the dynamic contact lens, and the choice of materials forming the different portions of the lens. For example, design elements include the thickness, stiffness, and / or radius of curvature of the different portions of the preformed dynamic contact lens, and the placement of protrusions on the front surface of the dynamic contact lens. Examples of material properties include the modulus of the materials forming the different portions of the dynamic contact lens.

[0145] The at least one first mechanism and the at least one second mechanism can be the same mechanism, or can be different mechanisms, e.g., including capillary forces and / or internal mechanical forces.

[0146] The dynamic contact lens provided by the present disclosure can include a central geometric axis.

[0147] The dynamic portion can be disposed at the center of the geometric axis, near the center of the central geometric axis, offset from the center of the geometric axis, or a combination of any of the foregoing. For example, the dynamic portion can be centrosymmetric and centered on the geometric axis of the dynamic contact lens. A near-center dynamic portion can be symmetrically disposed at a radial distance about the central geometric axis of the dynamic contact lens. The dynamic portion can also be located away from the center of the geometric axis.

[0148] In the conformal configuration, the dynamic portion can be configured to be substantially conformal to the cornea.

[0149] In the conformal configuration, the dynamic portion can be configured to adhere to the cornea. Adhering to the cornea means that, in the conformal configuration, the dynamic portion will assume a quasi-stable configuration in which the back surface of the dynamic portion is separated from the front surface of the cornea by a thin layer of tear fluid. The adherence to the cornea can be temporary. The adherence can, for example, establish a quasi-stable equilibrium. The quasi-stable equilibrium can be disrupted by the application of a force.

[0150] The dynamic portion can adhere to the corneal surface by capillary forces.

[0151] A layer of liquid between two wetted surfaces can be referred to as a capillary bridge. Capillary adhesion between two surfaces is caused by capillary action that pulls liquid outward from a narrow gap. Capillary adhesion that pulls two surfaces toward each other can maintain the relative positions of the two surfaces in an equilibrium state. Disrupting the equilibrium, for example, by forcing the opposing surfaces apart, can reduce the capillary adhesion and cause the surfaces to separate.

[0152] In a non-conformal configuration, a tear lens can form within the volume between the posterior surface of the dynamic portion and the surface of the cornea. The tear lens can provide additional optical power to the eye. The tear fluid used to fill the tear lens can originate from the tear reservoir as disclosed herein, from the tear film between the dynamic contact lens, for example at the peripheral portion of the dynamic contact lens, from the periphery of the dynamic contact lens, for example adjacent to the conjunctiva, through a fenestration spanning the dynamic lens thickness, or a combination of any of the foregoing. In a dynamic contact lens that includes a fenestration extending from the anterior surface to the posterior surface of the dynamic contact lens, the tear fluid can also originate from the tear fluid on the anterior surface of the dynamic contact lens.

[0153] The dynamic portion of the dynamic contact lens can be configured to provide optical power for at least two different depths of vision. The depths of vision can include, for example, near vision, intermediate vision, and distance vision.

[0154] For example, the dynamic contact lens can be configured such that, when applied to the cornea, the dynamic portion provides a first uncorrected vision in a conformal configuration and a second corrected vision in at least one non-conformal configuration.

[0155] For example, the dynamic contact lens can be configured such that, when applied to the cornea, the dynamic portion provides a first uncorrected vision in a conformal configuration and a second corrected vision in at least one non-conformal configuration.

[0156] For example, the dynamic contact lens can be configured such that, when applied to the cornea, the dynamic portion provides a first uncorrected vision in a conformal configuration and a second corrected vision in at least one non-conformal configuration.

[0157] Each of the first and second visions can independently include distance vision, intermediate vision, or near vision. For example, the dynamic contact lens can be configured such that, when applied to the cornea, the dynamic portion provides a first uncorrected vision in a conformal configuration and a second corrected vision in at least one non-conformal configuration.

[0158] The mechanism for causing the change in configuration can include manipulating the tear reservoir.

[0159] A cavity can be formed in the back surface of the dynamic contact lens. The cavity can be disposed in a peripheral portion of the lens and outside of the optical zone so as not to interfere with vision. The cavity can be compressible or incompressible.

[0160] The cavity can be filled with tear fluid to form a tear reservoir when applied to the eye. The tear reservoir can be compressible or incompressible. The dynamic contact lens can include a compressible tear reservoir, an incompressible tear reservoir, or a combination thereof.

[0161] The tear reservoir can be compressible by the application of eyelid pressure. Eyelid pressure can be applied, for example, by changing the gaze angle of the eye, by normal blinking, by intentional blinking, by squinting, or by a combination of any of the foregoing.

[0162] The tear reservoir can be compressible by a force in a range of, for example, from 0.1 gm force to 10 gm force, from 0.2 gm force to 8 gm force, from 0.5 gm force to 6 gm force, from 1 gm force to 5 gm force, or from 2 gm force to 4 gm force.

[0163] To effectively induce a change in the conformation of the dynamic portion, it can only be necessary for the tear reservoir to be partially compressible. For example, to induce a change in conformation, an amount of tear fluid can be forced into the tear film gap between the back surface of the dynamic portion and the cornea. The amount of tear fluid can be sufficient to widen the gap or otherwise weaken capillary forces and release capillary adhesion. Subsequently, as the dynamic portion transitions to a non-conformal conformation, the tear fluid fills the expanded lens-like volume and at least some of the tear fluid can be drawn from the tear reservoir. Alternatively or additionally, by applying eyelid pressure to the tear reservoir, tear fluid can be intermittently, continuously, or semi-continuously forced into the gap between the dynamic back surface and the cornea to provide one or more discrete non-conformal conformations or one or more continuous non-conformal conformations.

[0164] The tear reservoir can also be involved in the mechanism for transitioning from a non-conformal conformation to a conformal conformation. Upon release from a fully compressed or partially compressed state, the tear reservoir can be configured to expand. The expanded lens-like volume of the tear reservoir can draw tear fluid from the tear film and from the tear lens. The result of filling the tear reservoir can be to pull the back surface of the dynamic portion against the cornea to establish or restore a quasi-stable state of conformal conformation.

[0165] One or more tear reservoirs can be configured to compress only during gaze changes when pressure is applied by the eyelid. The pressure applied by the eyelid to the anterior surface of the cornea and / or to the compressible tear reservoir during gaze changes can be provided by the anterior surface that is in dynamic contact with the eyelid. Greater force can be applied to the compressible tear reservoir by normal blinking, by intentional blinking, and / or by squinting, where squinting can be held for a certain amount of time and with a certain amount of force.

[0166] Thus, the at least one first mechanism, the at least one second mechanism, or both the at least one first mechanism and the at least one second mechanism can include manipulating fluid within one or more tear reservoirs. The tear reservoirs can be fluidly coupled to the tear film or to the tear lens between the back surface of the peripheral portion and the cornea through the tear film between the back surface of the peripheral portion and the cornea.

[0167] The cavity can be configured such that during compression, tear is preferentially pushed under the dynamic portion, and when released, tear is preferentially drawn from under the dynamic portion of the dynamic contact lens. This can be achieved, for example, by a suitable choice of shape of the cavity / tear reservoir. For example, a suitable shape can include a cross-sectional profile that narrows towards the dynamic portion, such as a wedge-shaped cavity / tear reservoir.

[0168] The dynamic contact lens can include one or more tear reservoirs.

[0169] The single tear reservoir can include a concentric cavity disposed at a radial distance from a central geometric axis of the dynamic contact lens. The single tear reservoir can include a cavity disposed only in a portion of the peripheral portion. For example, the single tear reservoir can include an arcuate cavity located on half of the peripheral portion of the dynamic contact lens. For example, the arcuate cavity can be disposed at a radial distance from a central geometric axis of the dynamic contact lens and configured to be worn such that, when worn by a user, the arcuate tear reservoir is on a lower portion of the dynamic contact lens. The single tear reservoir can be configured such that the reservoir can interact with the eyelid. More than one circular reservoir can be provided such that each reservoir can, for example, have a different inner diameter. The circular reservoirs can also have compartments such that, when pressure is applied to the reservoir, tear preferentially moves towards the dynamic portion rather than within the circular reservoir.

[0170] The dynamic contact lens can include two or more tear reservoirs, such as a plurality of tear reservoirs. The tear reservoirs can be shaped or disposed in the peripheral portion to suit interaction with one or both eyelids, as well as to cause a transition between conformal and non-conformal configurations. The tear reservoirs can be disposed symmetrically or asymmetrically around the dynamic portion. The tear reservoirs can be disposed outside the optical zone so as not to interfere with vision.

[0171] The at least one first mechanism, the at least one second mechanism, or both the at least one first mechanism and the at least one second mechanism can include exchanging tear during a change in gaze when the eyelid exerts pressure on the dynamic contact lens by compressing the dynamic portion and / or compressing the peripheral portion of the dynamic contact lens. Exchanging tear can include exchanging tear between the tear film between the back surface of the dynamic portion and the cornea, the tear film between the peripheral back surface and the cornea, the tear lens, the one or more tear reservoirs, tear at the periphery of the lens, tear on the front surface of the lens, or a combination of any of the foregoing.

[0172] The at least one first feature, the at least one second feature, or both the at least one first feature and the at least one second feature can comprise a protrusion on the front surface of the dynamic contact lens configured for interaction with the eyelid.

[0173] The dynamic portion can be contiguous with one or more tear reservoirs. In such a design, eyelid movement on the peripheral portion of the tear lens can cause the dynamic central portion to move toward the cornea, causing the dynamic portion to bulge forward. When bulging forward, the dynamic central portion can assume a conformal configuration or a non-conformal configuration. When bulging forward, the dynamic central portion can assume at least two different non-conformal configurations.

[0174] Similar features described can be used without tear reservoirs. The dynamic contact lens can not have cavities and tear reservoirs, and similar action of the eyelids and / or gaze angle of the eye can cause the transition between configurations and the tear lens can exchange tears with the tear film, for example.

[0175] The protrusions can be disposed on the front surface of the peripheral portion of the dynamic contact lens outside the optical zone so as not to interfere with vision.

[0176] The protrusions can be configured to provide a frictional force when in dynamic contact with the eyelid. The frictional force can cause the dynamic contact lens to move on the eye or, for example, can impart a compressive force to the dynamic portion sufficient to reduce the adhesive capillary force in the conformal state to release and thereby cause a transition from the conformal configuration to the non-conformal configuration. The protrusions can be disposed symmetrically or asymmetrically around the dynamic portion. The protrusions can comprise one or more concentric ridges located at different radial distances from the center of the dynamic contact lens. The protrusions can be discrete features, for example, positioned symmetrically about the dynamic central portion at angles of 120°, 90°, 60°, 45°, or 30°. The protrusions can be disposed on the dynamic contact lens outside the optical zone so as not to interfere with vision.

[0177] The protrusions are thickened regions in the anterior surface of the lens and are designed to generate mechanical forces when dynamic contact between the protrusions and the eyelid exists. The dynamic contact lens can include one or more protrusions. The one or more protrusions can be disposed at a distance from the dynamic portion, for example, in a range from 0.5 mm to 5.5 mm, from 1 mm to 5 mm, from 1.5 mm to 4.5 mm, or from 2 mm to 4 mm from the dynamic portion. The protrusions, for example, can have a size in a range from 0.5 mm to 3 mm, from 1 mm to 3 mm, or from 1 mm to 2 mm. The one or more protrusions can independently have a height from the anterior surface of the dynamic contact lens, for example, from 10 pm to 500 pm, from 50 pm to 450 pm, from 100 pm to 400 pm, or from 150 pm to 350 pm. The one or more protrusions can independently have any suitable cross-sectional profile, such as oval, kidney-shaped, dome-shaped, or rectangular, and the sides can have different slopes.

[0178] In embodiments where the protrusions cover the cavity, the protrusions can be designed to be compressible. In this context, compressible means that, in a configuration where the cavity is in a compressed state, the protrusions also move toward the cornea such that the height of the protrusions above the anterior surface of the dynamic lens is less than the height in the compressed state. For example, the protrusions can be substantially conformal to the curvature of the anterior surface to provide a substantially smooth profile.

[0179] In embodiments where the protrusions cover the cavity, the cross-sectional thickness at the overlap can be less than, the same as, or greater than the thickness of the adjacent peripheral portion.

[0180] The one or more protrusions can include surface features that increase friction, such as grooves, dimples, and ridges. The grooves, dimples, or ridges can have a size that is less than the size of the protrusion. For example, the height or depth of the grooves, dimples, or ridges can be less than 100 pm, less than 75 pm, less than 50 pm, or less than 25 pm. The size of the one or more features to increase friction between the eyelid and the dynamic lens can be selected to promote user comfort.

[0181] The position and height of the one or more protrusions can be selected such that movement of the eyelid against the protrusions can cause a change in the configuration of the dynamic portion of the dynamic contact lens. The mechanism by which the protrusions can cause a change in configuration can be through a change in capillary forces and / or a change in internal forces of the dynamic contact lens. The protrusions can be positioned such that the force of the eyelid against the one or more protrusions during downward gaze causes the dynamic portion to change configuration.

[0182] The one or more protrusions can cover the cavity, for example, the tear reservoir. The one or more protrusions can not cover or partially cover the cavity, for example, the tear reservoir.

[0183] Figures 23A-23C A view of a dynamic contact lens with protrusions on the front surface is shown. Figure 23A A cross-sectional view of a dynamic contact lens with a central dynamic portion 2301 and protrusions 2302 is shown. The peripheral portions (2304 and 2305) of the dynamic contact lens are coupled to the dynamic portion 2301 and feature two different curvatures. The peripheral portions include a portion with a first curvature 2304 between the dynamic portion 2301 and the curvature interface 2303, and a portion with a second curvature 2305 between the interface 2303 and the edge 2306 of the dynamic contact lens. Figure 23B A view of the front surface of a dynamic contact lens is shown, including a dynamic portion 2301, five (5) rectangular protrusions 2302 symmetrically disposed at a 72° angle about the central dynamic portion 2301, and a curvature interface 2303. Figure 23C A view of the back surface of a dynamic lens is shown, including a dynamic central portion 2301 and a curvature interface 2303. Figures 23A-23C The dynamic lens shown in does not include a cavity in the back surface of the dynamic lens.

[0184] Figures 24A-24C A view of a dynamic contact lens with protrusions on the front surface aligned with corresponding cavities in the back surface is shown. Figure 24A A side view of a dynamic contact lens with a central dynamic portion 2401 and protrusions 2402 on the front surface is shown. The peripheral portions (2404 and 2405) of the dynamic contact lens are coupled to the dynamic portion 2401 and feature two different curvatures. The peripheral portions include a portion with a first curvature 2404 between the dynamic portion 2401 and the curvature interface 2403, and a portion with a second curvature 2405 between the curvature interface 2403 and the edge 2406 of the dynamic contact lens. Figure 24B A view of the front surface of a dynamic contact lens is shown, including a dynamic portion 2401, five (5) rectangular protrusions 2402 symmetrically disposed at a 72° angle about the central dynamic portion 2401, and a curvature interface 2403. Figure 24C A view of the back surface of a dynamic lens is shown, including a dynamic central portion 2401, a peripheral portion with a first curvature 2404, a peripheral portion with a second curvature 2405, and a curvature interface 2403. Figures 24A-24C The dynamic lens shown in includes a cavity 2406 in the back surface of the dynamic lens. The cavity 2406 on the back surface can be aligned with and underneath the corresponding protrusion 2402 on the front surface of the dynamic lens.

[0185] It will be appreciated that such cavities can be compressible or deformable even in the absence of protrusions that are covered under, for example, eyelid pressure. Such compressibility can be achieved by thinning the lens thickness above the cavity or by increasing the size of the cavity, changing its geometry, changing the overall geometry of the lens, or by changing the stiffness in the region of the cavity, for example by using a material with a lower modulus and / or reducing the thickness of the peripheral portion near the cavity.

[0186] The dynamic tear lens can be fluidically coupled to at least one fenestration to facilitate tear movement from and to the space between the lens and the eye. The number of fenestrations can be, for example, from 1 to 50, such as from 1 to 20 or from 3 to 10, and can have, for example, an inner diameter from 50 pm to 600 pm, such as from 100 pm to 300 pm.

[0187] The dynamic contact lens provided by the present disclosure can include an optical zone, which refers to the region of the dynamic contact lens used for vision.

[0188] The dynamic portion overlaps at least a portion of the optical zone. The size of the dynamic portion can be smaller than, substantially the same as, or larger than the size of the optical zone.

[0189] The dynamic contact lens provided by the present disclosure can include a peripheral portion coupled to the dynamic portion, wherein the peripheral portion is configured to hold the dynamic contact lens on the cornea. The dynamic portion and the peripheral portion can be coupled at a transition zone. The transition zone can be configured, for example, sized, to facilitate, control, stabilize, destabilize, or a combination of any of the foregoing, a transition between conformal and / or non-conformal configurations.

[0190] For example, the cross-sectional thickness at the transition zone between the peripheral portion and the dynamic portion can be thinner or thicker than the thickness of the adjacent peripheral and / or dynamic portions of the dynamic contact lens. For example, in a cross-sectional profile of the dynamic contact lens, the thickness can gradually increase from a peripheral edge of the lens in the peripheral region toward the transition zone with the dynamic portion. The thickness of the dynamic portion can be substantially uniform and can be the same as, thinner than, or thicker than the transition zone thickness. The thickness of the dynamic portion can increase from the transition zone thickness toward the center of the dynamic portion. The thickness of the dynamic portion can decrease from the transition zone thickness toward the center of the dynamic portion.

[0191] The transition zone can be configured to facilitate maintaining quasi-stable configurations, facilitate transitioning between quasi-stable configurations, and / or control and / or facilitate fluid exchange with the tear lens.

[0192] The dynamic contact lens can include a dynamic portion comprising a first material characterized by a first modulus; and a peripheral portion comprising a second material characterized by a second modulus.

[0193] The first material and the second material can comprise the same material, or the first material and the second material can comprise different materials.

[0194] The first modulus can be greater than the second modulus, the first modulus can be less than the second modulus, or the first modulus can be the same as the second modulus.

[0195] The dynamic portion and the peripheral portion can comprise a single material characterized by a single modulus. It can be appreciated that, depending on the thickness of the dynamic lens at a radial distance from the center, the dynamic lens can be characterized by a stiffness that varies with radial distance from the center.

[0196] The first modulus can be in a range from, for example, 0.05 MPa to 100 MPa; and the second modulus can be in a range from 0.05 MPa to 100 MPa.

[0197] The first modulus can be in a range from, for example, 0.1 MPa to 2 MPa; and the second modulus can be in a range from 0.1 MPa to 2 MPa.

[0198] For example, the first modulus and the second modulus can independently be in a range from, for example, 0.05 MPa to 10 MPa, from 0.1 MPa to 8 MPa, from 0.15 MPa to 6 MPa, from 0.2 MPa to 4 MPa, from 0.25 MPa to 3 MPa, from 0.3 MPa to 2 MPa, from 0.3 MPa to 1.5 MPa, or from 0.3 MPa to 1.0 MPa.

[0199] Each of the first material, the second material, or the single material can independently comprise a silicone, a hydrogel, a silicone hydrogel, or a combination of any of the foregoing. Any suitable material for making a soft contact lens can be used. Although the dynamic portion can be made from a material that is different from the non-dynamic portion, a single base material can be used to make the dynamic contact lens, however, certain regions can be treated or modified to impart desired mechanical properties. For example, the peripheral portion and the dynamic portion can comprise the same base material, however, certain regions can be designed, for example, to have a higher crosslinking density or a lower crosslinking density to facilitate the ability of the dynamic portion to assume a quasi-stable configuration and / or to transition between quasi-stable configurations in response to forces exerted on the dynamic contact lens by the eyelids.

[0200] The dynamic contact lens can include a back surface; and at least a portion of the back surface can include a material, a surface treatment, or a combination thereof, selected to control capillary forces between the at least a portion of the back surface and the tear fluid, between the cornea and the tear fluid, between the back surface and the cornea, or a combination of any of the foregoing.

[0201] The material and / or surface treatment can be selected to provide surface hydrophobicity, hydrophilicity, polarity, charge, or other properties that can affect capillary forces. The properties of the back surface can be uniform or can be non-uniform. The surface properties of the back surface can be continuous or discontinuous.

[0202] Examples of suitable surface treatments include coatings, plasma treatments, and impregnations.

[0203] The material itself can be selected to establish the desired surface properties.

[0204] The properties of the back surface of the lens, including the peripheral portion and the dynamic portion, can be the same or can be different in one or more regions of the back surface. For example, one surface property can be needed to control capillary adhesion of the back surface of the dynamic portion to the cornea, and a different surface property, for example in the region between the tear reservoir and the dynamic portion, can be needed to facilitate tear exchange.

[0205] In a cross-sectional profile, the dynamic portion can include a back surface that includes a gap profile between the back surface and the cornea. The gap profile can be characterized by a gap differential, where the gap differential is the difference between a central gap height and a peripheral gap height. The gap profile includes a plurality of gap differentials that decrease with radial distance away from a center of the dynamic portion toward a peripheral transition zone with the peripheral portion. A maximum gap differential can be defined as the difference between the central gap height and a gap height at a periphery of the dynamic portion.

[0206] A conformal configuration can be characterized by a first maximum gap differential; a non-conformal configuration can be characterized by a second maximum gap differential; where the second maximum gap differential is greater than the first maximum gap differential.

[0207] The dynamic contact lens provided by the present disclosure can include a preformed shape. The preformed shape includes a dynamic portion that protrudes from a back surface toward a front surface from a peripheral base curvature of a peripheral portion.

[0208] The dynamic contact lens can not have a preformed dynamic portion that protrudes forward. The dynamic portion may, for example, have a front surface that is substantially continuous with the front surface of the peripheral portion. A tear lens under this configuration can be provided by making the thickness of at least a portion of the dynamic portion less than the thickness of the transition zone with the peripheral portion. Such a configuration can be useful to provide a lens with a negative optical power.

[0209] In one of the at least one non-conformal configurations, the dynamic contact lens can comprise a preformed shape.

[0210] The dynamic contact lens can comprise a peripheral portion comprising a peripheral back surface, wherein the peripheral back surface comprises a peripheral base curvature, and a dynamic portion comprising a dynamic back surface, wherein the dynamic back surface comprises a dynamic base curvature.

[0211] In the conformal configuration, the dynamic base curvature can be substantially the same as the peripheral base curvature.

[0212] In the non-conformal configuration, the dynamic base curvature can deviate from the peripheral base curvature. For example, the curvature of the dynamic portion can be greater than the peripheral base curvature.

[0213] The cornea can be characterized by a corneal curvature. The dynamic portion of the dynamic contact lens can comprise a dynamic back surface, wherein the dynamic back surface can be characterized by a dynamic base curvature. In the conformal configuration, the dynamic base curvature can be substantially the same as the corneal curvature. In the non-conformal configuration, the dynamic base curvature can deviate from the corneal curvature.

[0214] The dynamic contact lens can comprise a peripheral portion comprising a peripheral back surface, wherein the peripheral back surface comprises a peripheral base curvature, and a dynamic portion characterized by a central SAG height relative to the peripheral base curvature.

[0215] The dynamic portion can be characterized by a first central SAG height relative to the peripheral base curvature and assume a second configuration characterized by a second central SAG height relative to the peripheral base curvature, wherein the first central SAG height is not the same as the second central SAG height. The first central SAG height can be greater than the second central SAG height or can be less than the second central SAG height.

[0216] The dynamic portion can be configured to assume a first configuration characterized by a first central gap height relative to the peripheral base curvature, and a second configuration characterized by a second central gap height relative to the peripheral base curvature, wherein the first central gap height is not the same as the second central gap height. The first central gap height can be greater than the second central gap height or can be less than the second central gap height.

[0217] The dynamic contact lens provided by the present disclosure can comprise a peripheral portion comprising a peripheral back surface and a peripheral front surface, wherein the peripheral back surface comprises a peripheral base curvature; and a dynamic portion comprising a dynamic back surface and a dynamic front surface, wherein at least the dynamic back surface is convex from the peripheral base curvature toward the dynamic front surface.

[0218] The dynamic contact lens can include a dynamic portion including a dynamic back surface, where the dynamic back surface can be characterized by a dynamic base curvature; and a peripheral portion coupled to the dynamic portion, where the peripheral portion includes a peripheral back surface; and the peripheral back surface can be characterized by a peripheral base curvature.

[0219] In the first configuration, the dynamic base curvature can be substantially the same as the peripheral base curvature; and in the second configuration, the dynamic base curvature can deviate from the peripheral base curvature. In the second configuration, the dynamic base curvature can be less than the peripheral base curvature.

[0220] The dynamic contact lens can include a dynamic portion including a dynamic back surface, where the dynamic back surface includes a dynamic base curvature.

[0221] In the first configuration, the dynamic base curvature can be substantially the same as the corneal curvature; and in the second configuration, the dynamic base curvature can deviate from the corneal curvature. In the second configuration, the dynamic base curvature can be less than the corneal curvature.

[0222] The dynamic contact lens can include a peripheral portion including a peripheral back surface, where the peripheral back surface can be characterized by a peripheral base curvature; and a dynamic portion coupled to the peripheral portion, where the dynamic portion includes a central thickness, and a central SAG height relative to the peripheral base curvature or a proximal peripheral base curvature adjacent the dynamic portion, a gap height when applied to a cornea.

[0223] The dynamic portion can be configured to assume a first configuration characterized by a first central gap height relative to the peripheral base curvature, and can be configured to assume a second configuration characterized by a second central gap height relative to the peripheral base curvature.

[0224] The first central gap height and the second central gap height can not be the same.

[0225] The first configuration and the second configuration can be quasi-stable.

[0226] The dynamic contact lens can include a dynamic portion including a back surface, where the back surface includes a dynamic base curvature.

[0227] In the first configuration, the back surface of the dynamic portion can be characterized by a first base curvature; and in the second configuration, the back surface of the dynamic portion can be characterized by a second base curvature.

[0228] The first configuration can be configured to provide a first optical power to an eye having a cornea; and the second configuration can be configured to provide a second optical power to the eye.

[0229] The first base curvature can be substantially the same as a corneal curvature.

[0230] The dynamic contact lens may also include at least one first feature, such as a protrusion, configured to cause a change between a first configuration and a second configuration; and at least one second mechanism configured to cause a change between a second configuration and a first configuration.

[0231] In the dynamic contact mirror provided in this disclosure, the dynamic part can be dome-shaped and can have a circular cross-section.

[0232] The dynamic contact lens disclosed herein may include a dynamic portion, wherein a pre-fabricated dynamic portion includes a SAG height and a central thickness, wherein the central thickness is less than the pre-fabricated SAG height; and a peripheral portion coupled to the dynamic portion, wherein the peripheral portion is configured to retain the dynamic contact lens on the cornea. Reference Figure 1A The SAG height is the distance between the curvature of the outer portion across the extension of the dynamic portion and the rear surface of the dynamic portion at the central axis of the dynamic portion.

[0233] The dynamic features can be found in the SAG height, center thickness, radial thickness, rear surface profile, front surface profile, diameter, and for spherical profiles, the rear radius of curvature and the front radius of curvature.

[0234] The height of the prefabricated SAG in the dynamic section ( Figure 1A The 110 in the figure can be in the range of, for example, 5 μm to 300 μm, 10 μm to 250 μm, 15 μm to 200 μm, 20 μm to 150 μm, 30 μm to 125 μm or 40 μm to 100 μm.

[0235] In non-conformal configurations, the gap height ( Figure 1A The 110 in the figure can be in the range of, for example, 5 μm to 300 μm, 10 μm to 250 μm, 15 μm to 200 μm, 20 μm to 150 μm, 30 μm to 125 μm or 40 μm to 100 μm.

[0236] The center thickness of the dynamic contact mirror ( Figure 1A 112) can be in the range of, for example, 10 μm to 600 μm, 20 μm to 600 μm, 30 μm to 600 μm, 40 μm to 500 μm, 50 μm to 400 μm, 100 μm to 300 μm, 150 μm to 200 μm, 50 μm to 100 μm, 100 μm to 150 μm, 150 μm to 200 μm, 200 μm to 250 μm, or 250 μm to 300 μm.

[0237] Dynamic part ( Figure 1AThe feature of 115) may be a diameter in the range of, for example, 1 mm to 7 mm, 1.5 mm to 6 mm, 1.5 mm to 5 mm, 2 mm to 5 mm, 2 mm to 4 mm or 2.5 mm to 3.5 mm.

[0238] Transition zone ( Figure 1A 108) may have a thickness in the range of, for example, from 10 μm to 600 μm, from 20 μm to 600 μm, from 30 μm to 600 μm, from 40 μm to 500 μm, from 50 μm to 400 μm, from 100 μm to 300 μm, from 150 μm to 200 μm, from 50 μm to 100 μm, from 100 μm to 150 μm, from 150 μm to 200 μm, from 200 μm to 250 μm, or from 250 μm to 300 μm.

[0239] The dynamic part may have a spherical profile, and the radius of curvature of the rear surface and / or the front surface may be in the range of, for example, from 5 mm to 10 mm, from 4 mm to 9 mm, from 3 mm to 8 mm, from 5 mm to 6 mm, from 6 mm to 7 mm, from 7 mm to 8 mm, from 8 mm to 9 mm, from 9 mm to 10 mm, or from 10 mm to 11 mm.

[0240] The dynamic portion of a dynamic contact mirror may include a rear surface and a front surface.

[0241] When manufactured, the shape of the dynamic portion, including the rear and front surfaces, may include outward protrusions or domes, wherein the dynamic portion extends in a profile in a direction from back to front and away from the peripheral base curvature.

[0242] In the dynamic contact lens provided in this disclosure, the dynamic portion can be configured to take two or more configurations, each of which is non-conformal to the surface of the cornea. Therefore, the dynamic contact lens may include a dynamic portion comprising at least one first non-conformal configuration configured to provide a first optical power to an eye having a cornea; and at least one second non-conformal configuration configured to provide a second optical power to the eye, wherein the second optical power differs from the first optical power; at least one first physical feature configured to cause a change between the first non-conformal configuration and the at least one second non-conformal configuration; and at least one second physical feature configured to cause a change between the at least one second non-conformal configuration and the at least one first non-conformal configuration.

[0243] The volume of the tear lens can range, for example, from 0.001 pL to 0.01 pL, from 0.001 pL to 0.1 pL, from 0.01 pL to 10 pL, from 0.02 pL to 8 pL, from 0.05 pL to 7 pL, from 0.1 pL to 6 pL, from 0.1 pL to 5 pL, from 0.5 pL to 4 pL, or from 1 pL to 3 pL.

[0244] The peripheral portion can have a diameter ranging, for example, from 8 mm to 17 mm, from 8.5 mm to 16.5 mm, from 9 mm to 16 mm, from 9.5 mm to 15.5 mm.

[0245] The peripheral portion can be characterized by a base curvature, i.e., a front surface curvature ranging, for example, from 7 mm to 10 mm, from 7.2 mm to 9.8 mm, from 7.4 mm to 9.6 mm, from 7.6 mm to 9.4 mm, from 7.8 mm to 9.2 mm, or from 8 mm to 9 mm.

[0246] In certain dynamic contact lenses provided for in the present disclosure, the dynamic portion can be configured to facilitate dynamically changing between configurations when applied to an eye. For example, the dynamic portion can change configuration during dynamic contact with the eyelid, e.g., by changing gaze angle, by normal blinking, by intentional blinking, by keeping the eyelid closed, or by squeezing the eyelid against the eye.

[0247] The back surface and the front surface of the dynamic portion can independently have a spherical profile or a non-spherical profile. For example, the thickness of the dynamic portion can be substantially constant across the profile, can be thinner toward the center than toward the transition zone, or can be thicker toward the center than toward the transition zone.

[0248] The dynamic contact lens can have a dynamic portion including a back surface characterized by a first radius of curvature; and a peripheral portion characterized by at least one second radius of curvature, wherein the first radius of curvature is smaller than the second radius of curvature. In other words, the dynamic portion extends forward from the peripheral base curvature.

[0249] The dynamic portion of the dynamic contact lens includes a thickness. The thickness of the dynamic portion can include a center thickness, which refers to the thickness of the dynamic portion at a physical center of the dynamic portion, and a plurality of radial thicknesses spanning segments of the dynamic portion from the center to a transition zone of the dynamic portion with the peripheral portion.

[0250] The thickness of the dynamic portion can be substantially uniform across the profile. In certain lenses, the thickness can vary or be non-uniform across the profile. For example, the center thickness can be greater than each of the plurality of radial thicknesses. The thickness of the dynamic portion can be radially symmetric about a central axis of the dynamic portion.

[0251] The thickness of the dynamic portion can not be uniform across the profile. The thickness can be greater toward the center compared to the periphery or less toward the center compared to the periphery. The thickness of the dynamic portion can also vary across the profile.

[0252] The dynamic portion and the optical portion can be aligned with the visual axis of the dynamic contact lens. The visual axis of the dynamic contact lens refers to the central axis of the lens. In some embodiments, the dynamic portion is not aligned with the visual axis of the lens.

[0253] The optical region can be characterized by a diameter ranging from, for example, 1 mm to 8 mm, from 2 mm to 7 mm, or from 3 mm to 6 mm.

[0254] The dynamic portion and the peripheral portion of the dynamic contact lens provided by the present disclosure can comprise silicone, hydrogel, or silicone hydrogel.

[0255] The dynamic portion and the peripheral portion of the dynamic contact lens can comprise the same material. The dynamic portion and the peripheral portion can comprise different materials that are characterized, for example, by different physical and / or mechanical properties. The dynamic portion and the peripheral portion can be characterized by materials having different moduli, and the portions can exhibit different stiffnesses.

[0256] The dynamic portion and the peripheral portion can also be characterized by stiffness. Cross-sectional stiffness is directly proportional to the modulus of the material multiplied by the cube of the cross-sectional thickness. It can be appreciated that when the peripheral portion comprises a single material, the cross-sectional stiffness increases as the thickness increases from the edge of the peripheral portion toward the transition zone with the dynamic portion.

[0257] The dynamic contact lens provided by the present disclosure can comprise a deformable dynamic portion and a peripheral portion coupled to the deformable dynamic portion. The dynamic portion can be configured to deform to accommodate a depth of vision. The peripheral portion can be configured to hold the dynamic contact lens on the cornea.

[0258] The lenticular volume between the back surface of the dynamic portion and the front surface of the cornea can be filled with tear fluid to form a tear lens when the dynamic contact lens is applied to the eye. In a dynamic contact lens, the dynamic portion is configured to change shape according to a visual distance. The change in the configuration of the dynamic portion provides a dynamic tear lens. The configuration of the dynamic portion can change continuously, or can take discrete configurations. It will be appreciated that a dynamic contact lens having a dynamic portion can be manufactured to have a dome extending outwardly (in a posterior-to-anterior direction) from the curvature of the peripheral portion. It will also be appreciated that when a user wears a manufactured lens having a dome extending outwardly, the dome can extend less outwardly than when manufactured. In other words, the dynamic contact lens can stretch outwardly when applied to the cornea.

[0259] The first configuration and the second configuration correspond to different optical powers imparted by the tear lens. The first configuration can be suitable for distance vision, and the second configuration can be suitable for near vision. The first configuration can be suitable for near vision, and the second configuration can be suitable for distance vision.

[0260] The purpose of the dynamic portion is to facilitate changing the optical power of the dynamic portion in response to the viewing distance of the eye. For example, in the first configuration suitable for distance vision, the dynamic portion will be disposed near the corneal front surface, while for near vision, the dynamic portion will extend away from the cornea to form the tear lens.

[0261] In certain dynamic contact lenses, the optical power of the dynamic portion does not change when the configuration of the dynamic portion changes. In other words, the change in optical power of the dynamic portion is primarily or entirely due to the change in optical power of the tear lens. For example, the thickness of the dynamic portion, as well as the relative cross-sectional profiles of the back surface and the front surface of the dynamic portion, do not change as the dynamic portion assumes different configurations. The shape of the peripheral portion can not change significantly when the configuration of the dynamic portion changes. The peripheral portion can be configured to hold the dynamic contact lens on the cornea, to center the dynamic contact lens on the optical zone of the cornea, and to minimize translation of the dynamic contact lens on the cornea. For example, the translation of the lens on the cornea can be less than ±1.5 mm, less than ±1.0 mm, or less than ±0.5 mm.

[0262] The central thickness of the dynamic portion and the radial thickness of the dynamic portion can not change significantly in different configurations. For example, the dynamic portion can include a plurality of radial thicknesses, and the plurality of radial thicknesses in the first configuration is substantially the same as the corresponding radial thicknesses in the second configuration.

[0263] The uniform profile of the dynamic portion with varying configurations can also be considered in terms of curvature. In certain dynamic contact lenses, the dynamic portion will not have an optical power, and the back surface and the front surface of the dynamic portion will have a spherical profile characterized by the same radius of curvature. The radius of curvature can be defined by the diameter of the dynamic portion, the thickness of the peripheral portion at the transition zone with the dynamic portion, and the gap height.

[0264] In certain dynamic contact lenses, the dynamic portion can include a back surface comprising a first radius of curvature, the dynamic portion can include a front surface comprising a second radius of curvature, and the ratio of the first radius of curvature to the second radius of curvature in the first configuration is the same as the ratio in at least one second configuration.

[0265] In certain dynamic contact lenses, the dynamic portion can be characterized by a plurality of radial thicknesses, where each radial thickness of the plurality of radial thicknesses is substantially the same across the entire gap height range that the dynamic portion can attain.

[0266] The dynamic portion can be configured to change in shape when a force is applied to the dynamic contact lens by an eyelid. The force can be applied to the peripheral portion, to a region of the peripheral portion, and / or to the dynamic portion.

[0267] The eyelid force can be applied by changing gaze angle, such as forward gaze for distance vision, or downward gaze for near vision, for example. The eyelid force can be applied by normal blinking or by intentional blinking. Intentional blinking can involve holding the eyelid closed for a period of time, squeezing the eyelid closed for a period of time, and / or repeating each of the foregoing multiple times.

[0268] The eyelid force can be used to transition the dynamic portion from one shape to another, and / or to accelerate the transition from one shape to another.

[0269] The optical power of the tear lens can change as the dynamic portion changes shape due to the force applied by the eyelid.

[0270] Upon manufacture, the dynamic portion of the dynamic contact lens extends forward relative to the extended profile of the peripheral portion of the dynamic contact lens to form a dome.

[0271] In the dynamic portion's shape adjacent the corneal anterior surface, the dynamic portion can be held in such a quasi-stable shape by a combination of adhesive and cohesive capillary forces. As the tear film layer thickness decreases, the adhesive force between the dynamic portion's posterior surface and the corneal anterior surface will become greater than the cohesive force of the tear fluid, resulting in the dynamic portion assuming a quasi-stable shape in which the dynamic portion is substantially conformal to the surface of the cornea.

[0272] Various methods and features can be used to facilitate the transition of the dynamic portion between two or more shapes caused by the eyelid force.

[0273] In certain methods, the capillary force holding the dynamic portion against the cornea can be disrupted by increasing the spacing between the two surfaces. This can be accomplished, for example, by pushing the tear fluid between the surfaces, thereby reducing the adhesive force and causing the dynamic portion's posterior surface to release. Depending on the configuration, the dynamic portion can assume a fully extended, dome-shaped configuration upon release, and tear fluid can be drawn from the transition zone between the posterior surface of the peripheral portion and the cornea in order to fill the tear lens with tear fluid. Alternatively or in combination, repeated blinking can be used to facilitate the movement of tear fluid to and / or from the tear lens. Blinking can include intentional blinking, whereby the user can achieve the desired vision correction without fully extending the dynamic portion.

[0274] In some methods, the frictional force applied by the eyelid to the peripheral portion can be used to alter the configuration of the dynamic portion, thereby changing the optical power of the tear lens. In such methods, the eyelid can grasp the peripheral portion and physically press the dynamic contact lens toward the center to apply a force sufficient to overcome the capillary forces holding the dynamic portion against the cornea, thereby causing the posterior surface of the dynamic portion to release and provide the tear lens. Examples of physical lens features that can be used to enhance the ability of the eyelid to apply mechanical force include protrusions, such as ridges on the anterior surface of the peripheral portion of the dynamic contact lens, thickening in the peripheral portion, features to increase the frictional force between the edge of the peripheral portion and the conjunctiva, and the use of multiple curvatures in the peripheral portion.

[0275] By blinking intentionally, the dynamic part of the eye in an extended configuration can come into contact with the surface of the cornea.

[0276] exist Figure 2A and Figure 2B The cross-section of the dynamic tear lens is shown in the figure. Figure 2A A dynamic tear lens is shown in a configuration suitable for uncorrected distance vision. Figure 2B A dynamic tear lens in a configuration suitable for corrected near vision is shown.

[0277] Figure 2A and Figure 2B The system includes a dynamic contact lens 200, which has a dynamic portion 201 and a peripheral portion 202. The dynamic portion 201 includes a posterior inner surface 203 and an anterior inner surface 204, and the peripheral portion 202 includes a posterior peripheral surface 205 and an anterior peripheral surface 206. The dynamic contact lens 200 abuts against the anterior surface 207 of the cornea 208. A tear film 209 is located between the posterior surfaces 203 / 205 of the dynamic contact lens 200 and the anterior surface 207 of the cornea 208. A tear reservoir 210 is filled with tear fluid. An eyelid 211 faces the periphery of the dynamic contact lens and does not compress the tear reservoir (see [link to documentation]). Figure 2A The line of sight is aligned with visual axis 212, consistent with uncorrected distance vision.

[0278] Suitable for uncorrected farsightedness Figure 2A In the cornea, the dynamic portion 201 conforms to and / or is adjacent to the anterior surface of the cornea. A tear reservoir 210, located in the peripheral posterior surface 205, is filled with tears. The eyelid 211 is located away from the tear reservoir 210.

[0279] Suitable for corrected near vision Figure 2B In the middle, when the eye moves downward 212 to focus on a nearby object (looking downward), the eyelid 211 fills the tear reservoir ( Figure 2AThe inner posterior surface 203 moves over the posterior surface 219 of the reservoir, thereby compressing the reservoir to push the tear fluid towards the dynamic portion. At the same time, the adhesion of the inner posterior surface 203 to the anterior surface 209 of the cornea 208 decreases, causing the dynamic portion 201 to bulge outward and away from the cornea 208. A tear lens 213 is formed between the inner posterior surface 203 and the anterior surface 209 of the cornea 208, which acts to correct myopia. Figure 2B Other elements shown in Figure 2A are shown in

[0280] Figure 2C and Figure 2D show dynamic contact lens configurations similar to those shown in Figure 2A and Figure 2B show dynamic contact lens configurations similar to those shown in Figure 2C and Figure 2D elements shown in Figure 2A are shown in

[0281] Figures 3A-3D shows an optical coherence tomography (OCT) image of a cross-section of an example of a dynamic contact lens provided by the present disclosure positioned on a cornea. Figures 3A-3D shows a dynamic contact lens 300, a bulging dynamic portion 301, and a peripheral portion 302. The dynamic contact lens is positioned on a cornea 306. Figure 3A shows a dynamic contact lens with no gap and no bulge when the inner dynamic portion is positioned near the surface of the cornea. Figures 3B-3D shows a dynamic contact lens with gap heights of 43 pm, 84 pm, and 105 pm, respectively. Figures 3B-3D The bulging of the inner dynamic portion shown in

[0282] In addition to or in lieu of the methods described above, the conformational changes of the dynamic portion can be facilitated by manipulating the flow of tear fluid into and out of the tear reservoir.

[0283] The dynamic contact lenses provided by the present disclosure can include a plurality of cavities positioned on the posterior surface of the peripheral portion. Desirably, the cavities are positioned outside the optical zone of the lens so as not to interfere with vision.

[0284] The dynamic contact lenses can be manufactured such that the posterior surface of the peripheral portion includes one or more cavities.

[0285] The one or more cavities can be configured to provide one or more tear reservoirs when the dynamic contact lens is applied to the cornea.

[0286] One or more cavities can be configured to provide one or more compressible tear reservoirs when the dynamic contact lens is applied to the cornea. The thickness of the peripheral portion between the cavities and the anterior surface of the peripheral portion can be thin enough such that the force applied by the eyelid is able to compress the cavities. The eyelid force can be applied by blinking, intentional blinking, or by the eyelid moving over the cavities.

[0287] The cavities can be disposed and configured in any suitable manner to facilitate the transition of the dynamic portion between the two or more configurations.

[0288] For example, one or more cavities can be symmetrically disposed around the dynamic portion. One or more cavities can be asymmetrically disposed around the dynamic portion.

[0289] One or more cavities can include one or more concentric rings, one or more grooves, one or more wedge-shaped cavities, and / or one or more circular cavities.

[0290] The cavities can be continuous around the dynamic portion, or can include a plurality of separate cavities. The cavities can be elongated, such as rectangular or wedge-shaped, with the long axis pointing towards the center of the lens. The separate cavities can be fluidically coupled with channels to facilitate filling and flow of tears between the cavities and / or between the cavities and the dynamic portion.

[0291] For example, the separate cavities can have a width ranging from 0.1 mm to 5 mm, a length ranging from 0.1 mm to 5 mm, and a depth ranging from 10 pm to 200 pm.

[0292] The cavities can be continuous, semi-continuous, or separate. A continuous cavity refers to a single cavity disposed around the dynamic portion. An example of a continuous cavity is a single concentric ring or a plurality of concentric rings. The concentric rings can have any suitable cross-sectional shape. For example, the cross-sectional shape can be circular, elliptical, square, rectangular, triangular, and / or angular. The plurality of concentric rings can be fluidically coupled by one or more fluid channels.

[0293] An example of a separate fluidic cavity is a plurality of cavities disposed around the dynamic portion of the dynamic contact lens. The plurality of cavities can be symmetrically disposed around the dynamic portion, such as 45° apart, or can be spaced apart around the dynamic portion. For example, the cavities can be disposed in groups around the dynamic portion at intervals of, for example, 120°, 90°, 60°, 45°, or 30°, or any other suitable interval. The separate cavities can have any suitable size and cross-sectional shape. For example, the separate cavities can have a hemispherical or triangular cross-sectional shape. The cavities can be elliptical, rectangular, cylindrical, circular, or any other suitable cross-sectional shape. The cavities can be symmetric, or can be characterized by a length that is different than the width.

[0294] The one or more cavities can be disposed a distance from the dynamic portion, such as in a range from 0.5 mm to 5.5 mm, from 1 mm to 5 mm, from 1.5 mm to 4.5 mm, or from 2 mm to 4 mm from the dynamic portion. The cavities can have a size, for example, in a range from 0.5 mm to 3 mm, from 1 mm to 3 mm, or from 1 mm to 2 mm. The one or more cavities can independently have a height from the front surface of the dynamic contact lens, such as from 10 pm to 500 pm, from 50 pm to 450 pm, from 100 pm to 400 pm, or from 150 pm to 350 pm. The one or more cavities can independently have any suitable cross-sectional profile, such as oval, kidney-shaped, dome-shaped, or rectangular, and the sides can have different slopes.

[0295] A semi-continuous cavity refers to a separate cavity fluidically coupled by a channel formed in the back surface of the dynamic contact lens. The channel can allow tear fluid to flow between adjacent tear reservoirs.

[0296] When disposed on the cornea, the cavities can be filled with tear fluid to form tear reservoirs.

[0297] When compressed due to movement of the eyelid or eyelid dynamics as the angle of gaze changes, tear fluid can be pushed toward the dynamic portion of the dynamic contact lens to disrupt the capillary forces holding the dynamic portion against the cornea and / or cause the SAG height to increase. The tear reservoirs can provide a source of tear fluid to fill the tear lens, thereby facilitating a faster response when changing from one configuration to another.

[0298] When the eyelid pressure is removed, the reservoirs can expand and act to pull tear fluid from the tear lens in order to fill the reservoirs with tear fluid, effectively pulling the dynamic portion toward the cornea. The cavities and resulting tear reservoirs can be used to push and pull tear fluid into and out of the tear lens. The cavities can be used to change the internal mechanical properties of the dynamic contact lens to facilitate the transition of the dynamic portion between quasi-stable configurations.

[0299] Figures 4A-4B A dynamic contact lens provided by the present disclosure is shown in which the tear reservoir comprises a groove. Figures 4A-4B The dynamic contact lens 400 shown in FIG. 4A comprises a dynamic portion 401, a peripheral portion 402, an inner back surface 403, an inner front surface 404, a peripheral back surface 405, and a peripheral front surface 406. A cavity in the form of a groove in the peripheral back surface of the lens provides a tear reservoir 407. As shown in FIG. 4B, the tear reservoir 407 is filled with tear fluid 408. Figure 4A As shown in FIG. 4C, for uncorrected distance vision, the back surface of the dynamic portion has a curvature corresponding to the front surface of the cornea (not shown). As shown in FIG. 4D, for uncorrected near vision, the back surface of the dynamic portion has a curvature corresponding to the back surface of the lens. Figure 4AAs further shown, the pressure exerted by the eyelid (not shown) on the recessed tear reservoir 407 causes tears to be pushed towards the dynamic portion, as indicated by arrow 408. The cross-section of the tear reservoir 407 is narrower towards the dynamic portion and deeper away from it. Figure 4A As further shown, the dynamic portion then deforms outward to form a bulge, beneath which a tear lenticule forms. Simultaneously, the tear reservoir compresses to press against the cornea. The tear lenticule can correct near vision. Figure 4B A bottom view of the lens, including the dynamic part 401, the concentric tear reservoir 407, and the peripheral part 402, is shown.

[0300] Figure 5A and 5B Cross-sectional and bottom views of a dynamic contact lens with a cavity for tear septum retention are shown. Figure 5A In the cross-section shown, the wedge-shaped cavity 507 is positioned around the deformable dynamic portion 501. Figure 5B In the bottom view shown, cavity 507 is symmetrically positioned within the peripheral portion 402 surrounding dynamic portion 501. The cavity may be wedge-shaped, with the narrower portion pointing towards the dynamic portion of the dynamic contact mirror.

[0301] Figure 6 Three (3) cross-sectional views of the dynamic contact lens provided in this disclosure are shown. The top view shows a pre-formed lens immersed in water. The dynamic portion of the lens is located at the center of the lens's geometric axis and convexes outward, away from the base curvature of the peripheral portion. The middle view shows the dynamic contact lens applied to the cornea. The dynamic portion is substantially conformal to the curvature of the cornea, and the base curvature of the dynamic portion is substantially the same as the base curvature of the peripheral portion. In the lower view of the dynamic contact lens applied to the cornea, the dynamic portion adopts a second configuration in which the dynamic portion convexes outward and is away from the cornea. The base curvature of the dynamic portion is different from the base curvature of the peripheral portion. A tear lenticule is formed between the posterior surface of the dynamic portion and the anterior surface of the cornea. Due to the tear lenticule, the dynamic contact lens in the lower view provides +3 diopters (+3D) of optical power compared to the conformal configuration shown in the middle view. The optical zone of the eye is located between the dynamic portion and the peripheral edge of the lens.

[0302] For example, based on calculations, for a lens with a certain diameter, the change from a non-conformal configuration to a second conformal configuration providing +3 diopter to the eye requires a certain gap difference (dome height). For example, for a lens with a 2mm optical diameter, the change from a non-conformal configuration to a second conformal configuration providing +3 diopter to the eye requires a gap difference of 5μm between the non-conformal and conformal configurations. Or, as... Figure 7For the example shown in FIG. 10, the gap increases by 19 pm for a lens with a 4 mm optical diameter, or 30 pm for a lens with a 5 mm optical diameter, providing an additional +3 diopters (+3D) of optical power. For these calculations, the anterior corneal base curve is R7.75 mm, and the anterior surface of the dynamic portion has a curvature of R7.25 mm when convex forward.

[0303] Figure 8 A cross-sectional view of a dynamic contact lens with a near peripheral tear reservoir is shown. The dynamic contact lens includes a dynamic portion 801 with an anterior surface 803 and a posterior surface 804, a peripheral portion 802 with an anterior surface 805 and a posterior surface 806, a peripheral edge 807, a central portion 817 and a central posterior surface 818, and a central thickness 812 of the dynamic portion 801. The curvature of the posterior surface 818 is the same or similar to the base curvature of the peripheral portion posterior surface 806.

[0304] Figures 9A-9C A cross-sectional view of a dynamic contact lens applied to a cornea 904 is shown. Figure 9A A tear reservoir 901 with a SAG height of 104 pm (left) and a tear lens 902 under the dynamic portion 903 of the lens with a SAG height of 72 pm (right) are shown. In Figure 9B In the dynamic contact lens of FIG. 10, the dynamic portion 903 is substantially conformal to the surface of the cornea 904, and the SAG height of the tear reservoir 901 is increased to 144 pm. In Figure 9C In the dynamic contact lens of FIG. 10, the dynamic portion 903 is substantially conformal to the surface of the cornea 904, and the SAG height of the tear reservoir 901 is increased to 144 pm. In Figure 9B After the tear reservoir 901 shown in FIG. 10 is subjected to a pressure of 0.1 gm force to 10 gm force, the dynamic portion 903 bulges from the cornea 904, reshaping the tear lens 902 with a SAG height of 76 pm, and the SAG height of the tear reservoir 901 is reduced to 120 pm.

[0305] For the dynamic contact lens shown in FIG. 10, the dynamic portion 1003 with the tear lens 1002 is located near center around the central geometric axis of the dynamic contact lens. The central portion of the dynamic contact lens is conformal to the surface of the cornea 1004. Figure 10

[0306] Symmetrically placing cavities and tear reservoirs around the dynamic portion can make the function of the dynamic contact lens independent of the orientation on the eye. Making the dynamic contact lens rotationally symmetric can aid the ability of the user to wear the dynamic contact lens.

[0307] ​This push / pull action of the compressible cavity to facilitate the transition of the dynamic portion from one configuration to another can be used as the sole mechanism for changing configurations, or can be augmented by intentional blinking. For example, intentional blinking can help stabilize a configuration in which the dynamic portion is adjacent to the corneal surface, for example, by expelling tear fluid from the tear fluid layer between the dynamic portion and the cornea or by thinning the tear fluid layer.

[0308] The dynamic contact lenses provided by the present disclosure can have a dynamic portion but not include a mechanism for transitioning between configurations. The dynamic contact lenses can have a preformed shape in which the dynamic portion is convex forward from the base curvature of the posterior surface of the peripheral portion. When applied to the cornea, the dynamic portion forms a tear lens. However, unlike a dynamic tear lens, in the present embodiments, the dynamic contact lens can produce a tear lens that does not change configuration with changes in eyelid pressure on the lens. In certain embodiments, the dynamic portion of the contact lens can be configured to resist deformation. With reference to a contact lens having a dynamic portion configured to assume a conformal configuration and at least one or more conformal configurations or a plurality of non-conformal configurations, a contact lens having a static tear lens will assume a single non-conformal configuration when placed on the cornea. The dimensions of the contact lens, the dynamic portion, and the peripheral portion of the lens configured to have a static tear lens can be configured to be the same as the dimensions of a contact lens in which the dynamic portion assumes a plurality of configurations. The contact lens having a static tear lens can be suitable for correcting vision in irregular corneas, for treating astigmatism, and for corneal wound healing. An example of a contact lens configured to have a static tear lens provided by the present disclosure is shown in FIG. Figure 1B Figure 1B A cross-sectional view of a contact lens having a dynamic portion and a peripheral portion is shown. When applied to the cornea, a tear lens (not shown) can be formed between the posterior surface of the dynamic portion 1001 and the anterior surface of the cornea.

[0309] The dynamic contact lenses provided by the present disclosure can include one or more fenestrations.

[0310] The one or more fenestrations can be disposed in the peripheral portion of the lens and outside of the optical zone so as not to interfere with vision.

[0311] The one or more fenestrations can extend through the thickness of the peripheral portion, fluidically coupling the anterior and posterior surfaces of the peripheral portion. The fenestrations can facilitate the flow of tear fluid to the tear film adjacent to the epithelium, and depending on the lens configuration, can facilitate the flow of tear fluid to and from the dynamic tear lens, and / or can facilitate the exchange of tear fluid along the epithelium to promote ocular health.

[0312] The one or more fenestrations can be fluidically coupled to one or more cavities. The fenestrations can allow tear fluid to flow from the anterior surface of the dynamic contact lens into the one or more cavities, which can facilitate the transition of the dynamic portion between different configurations. ​

[0313] The window can be fluidically coupled to a channel in the back surface of the dynamic contact lens. The channel can extend from the peripheral region of the lens to the dynamic portion. The channel can also be fluidically coupled to a fluid cavity, which can or can not be fluidically coupled to the dynamic region of the dynamic contact lens.

[0314] Figures 33A-41B A cross-sectional view of an example of a dynamic contact lens provided by the present disclosure is shown.

[0315] Figure 33A and Figure 33B A cross-sectional view of a dynamic contact lens is shown, having a central dynamic portion 3301 and a cavity 3302 in the back surface of the dynamic lens. The dynamic portion 3301 has a substantially uniform thickness. The profile of the dynamic lens is shown in a non-conformal configuration ( Figure 33A ) and a conformal configuration ( Figure 33B ). In the non-conformal configuration, the cavity is in a compressed state, while in the conformal configuration, the cavity is in a non-compressed state.

[0316] Figure 34A and Figure 34B A cross-sectional view of a dynamic contact lens is shown, having a central dynamic portion 3401, a cavity 3402 (in a compressed state) in the back surface of the dynamic lens, and a protrusion 3403 on the front surface of the dynamic lens and covering the respective cavity 3402. The profile of the dynamic lens is shown in a non-conformal configuration ( Figure 34A ) and a conformal configuration ( Figure 34B ). In the non-conformal configuration, the cavity is in a compressed state, while in the conformal configuration, the cavity is in a non-compressed state. The protrusion 3403 facilitates the ability of the cavity to compress under the pressure exerted by the eyelid.

[0317] Figure 35A and Figure 35B A cross-sectional view of a dynamic contact lens is shown, similar to that shown in Figure 34A and Figure 34B but where the protrusion is not aligned with the cavity. Figure 35A and Figure 35B The dynamic lens shown in Figure 35A and Figure 35B has a central dynamic portion 3501, a cavity 3502 in the back surface of the dynamic lens, and a protrusion 3503 on the front surface of the peripheral portion of the dynamic lens and not covering the cavity 3502. The profile of the dynamic lens is shown in a non-conformal configuration ( ) and a conformal configuration (

[0318] ). In the non-conformal configuration, the cavity is in a compressed state, while in the conformal configuration, the cavity is in a non-compressed state. The protrusion 3503 facilitates the ability of the cavity to compress under the pressure exerted by the eyelid. Figure 36A Figure 36BA cross-sectional view of a dynamic contact lens is shown having a central dynamic portion 3601 and a cavity 3602 in the back surface of the dynamic lens. The dynamic portion 3601 has a non-uniform thickness such that the center 3605 is thicker than at the peripheral transition zone 3606 with the peripheral portion 3607. The profile of the dynamic lens is shown in a non-conformal configuration ( Figure 36A ) and a conformal configuration ( Figure 36B ). In the non-conformal configuration, the cavity 3602 is in a compressed state, while in the conformal configuration, the cavity 3602 is in a non-compressed state.

[0319] Figure 37A and Figure 37B A cross-sectional view of a dynamic contact lens is shown having a central dynamic portion 3701 and a cavity 3702 in the back surface of the dynamic lens. The dynamic portion 3701 has a non-uniform thickness such that the center 3705 is thinner than at the peripheral transition zone 3706 with the peripheral portion 3707. The profile of the dynamic lens is shown in a non-conformal configuration ( Figure 37A ) and a conformal configuration ( Figure 37B ). In the non-conformal configuration, the cavity 3702 is in a compressed state, while in the conformal configuration, the cavity 3702 is in a non-compressed state.

[0320] Figure 38A and Figure 38B A cross-sectional view of a dynamic contact lens is shown having a central dynamic portion 3801 and a protrusion 3803 in the front surface of the dynamic lens. The dynamic portion 3801 has a non-uniform thickness such that the center 3805 is thinner than at the peripheral transition zone 3806 with the peripheral portion 3807. The profile of the dynamic lens is shown in a non-conformal configuration ( Figure 38A ) and a conformal configuration ( Figure 38B ).

[0321] Figure 39A and Figure 39B A cross-sectional view of a dynamic contact lens is shown having a central dynamic portion 3901, a cavity 3902 in the back surface of the dynamic lens, and a protrusion 3903 covering the respective cavity 3902. The dynamic portion 3901 has a non-uniform thickness such that the center 3805 is thinner than at the peripheral transition zone 3906 with the peripheral portion 3907. The profile of the dynamic lens is shown in a non-conformal configuration ( Figure 39A ) and a conformal configuration ( Figure 39B ). In the non-conformal configuration, the cavity 3902 is in a non-compressed state, while in the conformal configuration, the cavity 3902 is in a compressed state. In the conformal configuration, the protrusion 3903 is compressible to provide a substantially smooth front surface.

[0322] Figure 40A and Figure 40BA cross-sectional view of a dynamic contact lens is shown having a central dynamic portion 4001, a cavity 4002 in the back surface of the dynamic lens, and a protrusion 4003 covering the respective cavity 4002. The dynamic portion 4001 has a non-uniform thickness such that the center 4005 is thinner than at the peripheral transition zone 4006 with the peripheral portion 4007. The profile of the dynamic lens is shown in a non-conformal configuration ( Figure 40A ) and a conformal configuration ( Figure 40B ). In the non-conformal configuration, the cavity 4002 is in a non-compressed state, while in the conformal configuration, the cavity 4002 is in a compressed state. The protrusion 4003 is incompressible or partially compressible such that it protrudes from the front surface.

[0323] Figure 41A and Figure 41B A cross-sectional view of a dynamic contact lens is shown having a central dynamic portion 4101, a cavity 4102 in the back surface of the dynamic lens, and a protrusion 4103 that is not aligned with the cavity 4102. The dynamic portion 4101 has a non-uniform thickness such that the center 4105 is thinner than at the peripheral transition zone 4106 with the peripheral portion 4007. The profile of the dynamic lens is shown in a non-conformal configuration ( Figure 41A ) and a conformal configuration ( Figure 41B ). In the non-conformal configuration, the cavity 4102 is in a non-compressed state, while in the conformal configuration, the cavity 4102 is in a compressed state. The protrusion 4103 is incompressible or partially compressible such that it protrudes from the front surface.

[0324] Figures 33A-41B A dynamic contact lens in a non-conformal and conformal configuration is shown. The dynamic contact lens can assume at least one second non-conformal configuration in which the gap height is different from the other non-conformal configuration. The conformal configuration, as well as the one or more non-conformal configurations, is quasi-stable.

[0325] The back surface of the dynamic portion, the back surface of the peripheral portion, or the back surface of both the dynamic portion and the peripheral portion can include a surface treatment.

[0326] The surface treatment can be configured to control, modify, and / or select the adhesion and cohesion of tear fluid to the back surface of the dynamic portion, the back surface of the peripheral portion, or the back surface of both the dynamic portion and the peripheral portion.

[0327] The surface treatment can be applied to all or a portion of the inner back surface and / or the peripheral back surface of the dynamic contact lens.

[0328] In a dynamic contact lens that includes a cavity, the walls of the cavity and / or channels extending from the cavity can be surface treated.

[0329] The surface treatment can include, for example, a coating, a film, a chemical treatment, a plasma treatment, or a combination of any of the foregoing.

[0330] The surface treatment can be selected to change the hydrophobicity / hydrophilicity of the back surface of the dynamic portion, the back surface of the peripheral portion, or the back surface of both the dynamic portion and the peripheral portion.

[0331] The surface treatment can be selected to control and / or adjust the capillary forces between the back surface of the dynamic portion and the cornea.

[0332] The surface treatment can be selected to control and / or facilitate the flow of tears into and out of the tear lens.

[0333] The back surface of the dynamic contact lens can include a material selected to control the hydrophilicity / hydrophobicity of the back surface. The back surface can include a material selected to control the charge of the back surface, the polarity of the back surface, or a combination thereof.

[0334] Dk refers to the oxygen permeability, i.e., the amount of oxygen that passes through a device such as a dynamic contact lens, in a given period of time and pressure differential condition. Dk is expressed in units of 10 -11 (cm / sec)(mL O2)(mL x mmHg), also referred to as barrer. The oxygen permeability can be expressed as Dk / t, where t is the thickness of the structure (e.g., dynamic contact lens), and thus Dk / t represents the amount of oxygen that passes through a dynamic contact lens of a specified thickness in a given period of time and pressure differential condition. The units of oxygen permeability are barrer / cm or 10 -9 (cm / sec)(mL O2)(mL x mmHg).

[0335] Lens materials having an oxygen permeability promote eye health. For dynamic contact lenses, it is generally desirable for the oxygen permeability to be greater than about 80 Dk. It can be difficult to achieve such high oxygen permeability for high modulus materials and / or for thicker material cross sections.

[0336] The dynamic portion and the peripheral portion of the dynamic contact lens can include a material characterized by an oxygen permeability from about 10 Dk to about 500 Dk, from about 50 Dk to about 400 Dk, from about 50 Dk to about 300 DK, and in certain embodiments, from about 50 DK to about 100 Dk.

[0337] The dynamic contact lens can include a silicone or a silicone hydrogel having a low ion porosity. For example, the dynamic contact lens can include a silicone hydrogel or a silicone having a low ion permeability, and the water range can be from about 5% to about 35% such that the Dk is 100 x 10 -11 or greater. The low ion permeability can include no more than about 0.25 x 10-3 an Ionoton ion permeability coefficient of no more than about 0.08 x 10 -3 m2 / sec.

[0338] The dynamic contact lens can include a wettable surface coating disposed at least on the anterior surface of the dynamic contact lens such that the tear film is smooth over the dynamic contact lens. The wettable surface coating can include a lubricating coating to make the patient comfortable, for example, to lubricate the eye when the patient blinks. The wettable coating can produce a contact angle of no more than about 80°. For example, the coating can produce a contact angle of no more than about 70°, and the contact angle can be in a range of about 55° to 65° to provide a surface with a smooth tear layer for vision. For example, the wettable coating can be disposed on the superior surface and the inferior surface of the device, i.e., on the anterior surface and the posterior surface of the dynamic contact lens. The superior surface can include the wettable coating extending at least over the inner optical portion.

[0339] The wettable coating can include one or more suitable materials. For example, the wettable coating can include polyethylene glycol (PEG), and the PEG coating can be disposed on a Parylene TM Alternatively, the wettable coating can include a plasma coating, and the plasma coating can include a light emitting chemical vapor deposition (LCVD) film. For example, the plasma coating can include at least one of a hydrocarbon (e.g., CH4), O2, or fluorocarbon hydrocarbon (e.g., CF4) coating. Alternatively or in combination, the wettable coating can include a polyethylene glycol (PEG) coating or 2-hydroxyethyl methacrylate (HEMA). For example, the wettable coating can include HEMA disposed on a Parylene TM coating.

[0340] The dynamic contact lens provided by the present disclosure can have a water content of, for example, from 10 wt% to 70 wt%, such as from 30 wt% to 60 wt%, where wt% is based on the total weight of the dynamic contact lens.

[0341] The dynamic contact lens provided by the present disclosure can be manufactured using any method suitable for manufacturing contact lenses and, in particular, soft contact lenses. An example of a suitable method includes molding. The dynamic contact lens can be manufactured such that, when manufactured, the dynamic portion is convex outward to form a dome, a near center progression, or other forward facing surface profile.

[0342] Methods of manufacturing a dynamic contact lens, for example, include forming a dynamic contact lens that includes a dynamic portion, where the dynamic portion includes a SAG height and a center thickness, where the center thickness is less than the SAG height, and a peripheral portion coupled to the dynamic portion, where the peripheral portion is configured to hold the dynamic contact lens on a cornea. Methods of manufacturing a dynamic contact lens, for example, include forming a dynamic contact lens that includes a dynamic portion characterized by a dynamic base curvature, a peripheral portion coupled to the dynamic portion, where the peripheral portion includes a peripheral base curvature, where the dynamic base curvature is different than the peripheral base curvature. For example, the radius of curvature of the dynamic portion can be less than the radius of curvature of the peripheral portion. For example, the radius of curvature of the dynamic portion can be less than the radius of curvature of a paracentral peripheral portion, where the paracentral peripheral portion is a portion of the peripheral portion that abuts the transition zone and the dynamic portion. The material used to manufacture the dynamic lens can be a material suitable for use in a conventional soft contact lens. The material, for example, can include a Young’s modulus from 0.05 MPa to 30 MPa, from 0.1 MPa to 20 MPa, from 0.1 MPa to 10 MPa, from 0.1 MPa to 5 MPa, or from 0.1 MPa to 2 MPa.

[0343] The dynamic contact lenses provided by the present disclosure can be manufactured to have a preformed SAG height. The preformed center SAG height refers to the distance from the back surface at the center of the dynamic portion to the extension of the base curve of the paracentral peripheral portion adjacent to the dynamic portion. The preformed center SAG is shown as element 110 in Figure 1A with the dashed line being the extension of the base curve of the paracentral peripheral portion below the dynamic portion. The preformed SAG height is the maximum gap that can be achieved when the lens is placed on a cornea and the dynamic portion is filled with tear fluid to form a tear lens. A dynamic portion with a 40 pm preformed SAG height, for example, can produce a quasi-stable tear lens with a 40 pm, 30 pm, 20 pm, and / or 10 pm gap depending on a number of factors including tear fluid availability. A dynamic portion with a 100 pm preformed SAG height, for example, can produce a quasi-stable tear lens with a 100 pm, 90 pm, 80 pm, 70 pm, 60 pm, 50 pm, 40 pm, 30 pm, and / or 10 pm gap.

[0344] The dynamic contact lenses provided by the present disclosure can be used to correct or improve vision.

[0345] Methods for correcting vision in a patient can include applying a dynamic contact lens provided by the present disclosure to an eye of a patient in need of correction of vision.

[0346] Correcting vision can include correcting hyperopia, myopia, astigmatism, or presbyopia.

[0347] The methods provided by the present disclosure include treating presbyopia by applying a dynamic contact lens provided by the present disclosure to a patient's eye suffering from presbyopia.

[0348] The dynamic contact lenses provided by the present disclosure can be designed to dynamically correct vision. For example, presbyopia is characterized by an eye's inability to focus on near objects. The dynamic portion of the dynamic contact lenses provided by the present disclosure can dynamically change conformation to accommodate distance vision or near vision. For example, in connection with presbyopia, in a first conformation suitable for viewing distance objects, the dynamic portion of the dynamic contact lens can be adjacent to the cornea. In this conformation, there is no tear lens and distance vision is uncorrected. In turn, when the patient views near objects, the dynamic portion of the dynamic contact lens can assume a second conformation that corrects presbyopia and facilitates clear viewing of near objects. This is achieved without changing the radial thickness of the dynamic portion or by changing the curvature ratio of the dynamic portion. Rather, when the dynamic portion bulges outward, the lens-like volume expands to provide a tear lens for dynamically correcting near vision. The tear lens changes the optical power of the dynamic portion of the dynamic contact lens.

[0349] The dynamic contact lenses provided by the present disclosure can also function as multifocal lenses to correct presbyopia and prevent myopia progression.

[0350] The static conformation of the dynamic contact lenses provided by the present disclosure can be used to compensate for irregular corneas, to treat astigmatism, or for corneal wound healing.

[0351] The dynamic contact lenses incorporating a tear lens can correct vision due to irregularly shaped corneas. Irregularly shaped corneas can be permanent or temporary, for example, due to ophthalmic surgery including refractive keratotomy or corneal cross-linking. The tear lens can correct astigmatism. To treat such conditions, the dynamic contact lenses provided by the present disclosure with a static tear lens can be suitable.

[0352] The dynamic contact lenses provided by the present disclosure can be used to enhance or restore visual acuity following an ophthalmic treatment. The ophthalmic treatment can involve manipulation of ocular tissue and can be associated with pathology outside the optical zone. The ophthalmic treatment can involve incision of ocular tissue and implantation of a device within the optical zone. In certain embodiments, the ophthalmic treatment involves ablation of at least a portion of the stroma and / or epithelium. The ophthalmic treatment can include, for example, cataract surgery, including phacoemulsification, conventional extracapsular cataract extraction, and intracapsular cataract extraction; glaucoma surgery, including laser trabeculoplasty, iridotomy, iridectomy, sclerectomy, goniolysis, drainage implantation, and canaloplasty; corneal surgery, including keratoplasty, penetrating keratoplasty, keratoprosthesis, pterygium excision, corneal tattooing, and osteo-odonto keratoprosthesis implantation; and refractive treatment, including photorefractive keratectomy (PRK) and laser-assisted in-situ keratomileusis (LASIK). The ophthalmic treatment can also involve treatment of a wound of the eye, where the treatment can or can not involve ophthalmic surgery. The ophthalmic treatment can include cataract surgery, keratoplasty, keratoprosthesis, or treatment of a wound of an eye trauma. The ophthalmic treatment can include incision of the cornea and / or perforation of the cornea at a location outside the optical zone.

[0353] In general, ophthalmic treatments such as cataract surgery, keratoplasty, and keratoprosthesis can be distinguished from ophthalmic treatments that involve only manipulation of the optical zone of the cornea or primarily manipulation of the optical zone of the cornea. In the former category of ophthalmic treatments, which can be considered implant surgery due to the implantation of a device into ocular tissue as an aid or as a replacement for removed ocular tissue, the surgery involves manipulation of ocular tissue outside the optical zone as well as the optical zone itself. The latter category of treatment is exemplified by refractive surgery, in which the optical zone of the cornea is sculpted to correct refractive error. Examples of refractive surgery include, for example, PRK and LASIK. Ophthalmic treatments that involve manipulation of the optical zone of the cornea are also encompassed in the sense that the treatment also involves manipulation of ocular tissue outside the optical zone. For example, LASIK involves making an incision in the stroma outside the optical zone to create a flap. The flap is then turned up to expose the stroma, which is then ablated using a laser to provide a shape for refractive correction. Furthermore, ophthalmic manipulations involving tissue outside the optical zone and refractive surgery involving manipulation of tissue within the optical zone can be combined. For example, keratoplasty can be combined with an associated refractive surgery such as LASIK.

[0354] The dynamic contact lenses provided by the present disclosure can be used to treat the cornea after a corneal inlay procedure or a corneal onlay procedure. Corneal inlays and corneal onlays are tiny lenses or other optical devices that are inserted into the cornea to reshape the front surface of the eye (i.e., the corneal front surface) to improve vision, and which in some cases can resemble small contact lenses. The primary use of current corneal inlays is to improve near vision and to address presbyopia. In some cases, a corneal inlay procedure can be combined with a refractive procedure such as LASIK to simultaneously correct presbyopia and common refractive errors such as myopia, hyperopia, and / or astigmatism.

[0355] The dynamic contact lenses provided by the present disclosure can be used to treat the cornea after a cataract procedure. In some embodiments, the ophthalmic treatment includes a cataract procedure. A cataract procedure involves removing and replacing the natural lens of the eye that has developed into a cloudiness, which is referred to as a cataract.

[0356] The dynamic contact lenses provided by the present disclosure can be used to treat the cornea after a corneal transplant procedure. Corneal transplant treatments include, for example, penetrating keratoplasty, lamellar keratoplasty, deep lamellar keratoplasty, and endothelial keratoplasty.

[0357] The dynamic contact lenses provided by the present disclosure can accelerate the healing of ocular defects when applied to the eye of a patient after an ophthalmic treatment. Ocular defects include incisions and perforations in the cornea and / or other ocular tissue.

[0358] The dynamic contact lenses provided by the present disclosure can be used to treat the cornea after a cross-linking treatment. Corneal cross-linking is a technique that strengthens chemical bonds in the cornea, thereby helping the cornea’s ability to resist irregular changes in the shape of the cornea, known as ectasia.

[0359] The dynamic contact lenses provided by the present disclosure can be used to treat the cornea after refractive therapy (e.g., PRK and LASIK). Refractive ophthalmic surgery is used to improve the refractive state of the eye and includes, for example, procedures such as automated lamellar keratoplasty (ALK), laser-assisted in situ keratomileusis (LASIK), photorefractive keratectomy (PRK), laser-assisted subepithelial keratomileusis (LASEK), EPI-LASIK, radial keratotomy, micro- asymmetric radial keratotomy, arcuate keratotomy, limbal relaxing incision, corneal thermokeratoplasty, laser corneal thermokeratoplasty, intrastromal corneal onlay, and phakic intraocular lens implantation, among others. After any of these procedures, a period of time is required to recover optimal vision. For example, in LASIK, optimal vision is typically achieved within about 24 hours after the procedure. During this recovery period, in addition to suboptimal vision, the patient can also experience discomfort, such as photophobia or light sensitivity and / or a burning sensation. Methods for reducing the time to achieve optimal vision and for reducing or eliminating the discomfort associated with refractive ophthalmic surgery are desirable.

[0360] PRK is a surgical procedure in which the stroma is shaped using a laser to correct refractive errors. In this procedure, the epithelium overlying the portion of the stroma that is ablated is removed to create an epithelial defect.

[0361] LASIK is a surgical procedure for correcting refractive errors (e.g., myopia, hyperopia, and astigmatism) in which a laser is used to reshape the cornea to improve visual acuity, e.g., the sharpness and clarity of images. LASIK procedures include surgical cutting and laser sculpting of the cornea. During a LASIK procedure, the eye is immobilized by applying a soft corneal suction ring. A flap is then created in the outer cornea using a blade or laser, leaving a hinge at one end of the flap. The flap is then folded back to expose the middle portion of the stroma or cornea. A laser is then used to vaporize the corneal stroma to remove tissue, thereby reshaping the cornea to correct vision. After the stroma layer is reshaped, the flap is repositioned over the eye and held in place by natural adhesion. Optimal vision is typically achieved within about 24 hours after the procedure.

[0362] The dynamic contact lenses provided by the present disclosure can be configured to correct refractive errors, such as astigmatism. The lens provides a smooth spherical front surface and minimizes lens-induced aberrations by reducing the flexure of the inner optical portion and by maintaining the lens centered during wear. The reduced flexure of the inner optical portion can be achieved in part by increasing the stiffness of the inner portion and by forming a tear lens. The centering of the inner optical portion minimizes astigmatism and prism effects induced by tilting of the optics and also minimizes edge aberrations.

[0363] While the foregoing has focused on ophthalmic treatments associated with intentional manipulation of the eye, it is understood that the dynamic contact lens and methods of using the dynamic contact lens can also be used to treat other injuries to the eye, such as treating traumatic wounds. Eye trauma can also cause edema and compromise the interface between various ocular tissues. Thus, in addition to post-surgical methods, the dynamic contact lenses provided by the present disclosure can also be used to treat traumatic wounds of the eye. Trauma includes, for example, physical trauma such as blunt trauma and penetrating trauma, chemical trauma, blast injury, burn injury, and psychological trauma. Treatment of traumatic wounds can involve surgical procedures, such as removal of embedded physical objects or removal of scar tissue. To the extent that trauma causes edema and optical irregularities, application of the dynamic contact lens will result in faster visual recovery and accelerate healing by stabilizing the affected ocular tissue. Trauma can also cause defects in ocular tissue including the anterior surface of the cornea, and involve the epithelium and / or stroma, and can cause damage to intraocular tissue. Thus, wound healing includes healing of wounds associated with physical damage to ocular tissue, not necessarily resulting from surgical procedures.

[0364] The dynamic contact lenses provided by the present disclosure can also be used as prophylactic devices. For example, the dynamic contact lens can be used to protect the eye from potential injury, such as injury due to physical trauma, from chemical agents, from particulates, and to prevent edema. As a prophylactic device, the dynamic contact lens can be applied to the eye prior to anticipated contact with a potential injury. When worn to protect the eye from a potential injury, the dynamic contact lens can provide a physical barrier by virtue of the seal to the anterior surface of the eye, a chemical barrier, and / or can prevent or minimize edema caused by non-physical forces such as blast pressure or trauma to other parts of the body. In certain embodiments, protecting the eye from a potential injury includes protecting the eye from a gas, a vapor, dust, or smoke. In certain embodiments, the protection includes preventing edema.

[0365] Example

[0366] Embodiments provided by the present disclosure are further illustrated by reference to the following examples, which describe dynamic contact lenses and use of dynamic contact lenses provided by the present disclosure.

[0367] Example 1

[0368] Optical function of dynamic contact lenses in an eye model

[0369] Figure 11 Views of a dynamic contact lens having a dynamic portion are shown in FIGS. 1A-1C. The letter "A" is applied on a model cornea, and the dynamic contact lens is used over the letter and the model cornea. Features of the simulated eyelids are shown on the left and right sides of the eye. In FIG. 1A, the dynamic contact lens is not applied to the cornea. Figure 11 In FIG. 1C, no pressure is applied to the cornea.

[0370] AsFigure 12 As shown, when pressure is applied to the dynamic contact lens by moving the simulated eyelid towards the center (i.e., towards the dynamic portion), the refractive power of the dynamic central portion transitions to a more posterior power. As a result, the size of the letter "A" increases by approximately 170%.

[0371] like Figure 13 As shown, when the pressure on the artificial eyelid is released from the lens by moving the simulated eyelid away from the central dynamic portion, the refractive power of the dynamic central portion recovers to the initial optical power within approximately 100 milliseconds.

[0372] A saline solution was used to simulate tears.

[0373] Example 2

[0374] Optical function of dynamic contact lenses with a tear reservoir in an eye model

[0375] A dynamic contact lens with a dynamic section and a peripheral tear reservoir was placed on an eye model and imaged using OCT.

[0376] like Figure 14A As shown, the rightmost dynamic portion 1401 of the image is in a conformal state. There is no tear lenticule between the lens and the model cornea 1402. A tear reservoir 1403 with a height of 144 μm is visible on the left side of the image.

[0377] like Figure 14B As shown, when a light pressure is applied to the tear reservoir, the height of the reservoir 1403 decreases to 120 μm, and the dynamic portion 1401 adopts a non-conformal configuration to form a tear lens 1404 with a gap height of 76 μm.

[0378] Example 3

[0379] Optical function of lenses in an eye model

[0380] A dynamic contact lens with a dynamic component was placed on the eye of a 50-year-old man.

[0381] The dynamic contact lens has the following properties: a base curvature of 8.9 mm, a diameter of 14.5 mm, a center thickness of 100 μm, a thickness of 200 μm at a radius of 10 mm, a SAG of 200 μm, and a diameter of 20 mm for the dynamic part.

[0382] Use a standard automated refractometer to measure the refractive correction of the eye.

[0383] The eye's refractive error was determined to be -2.25D, and the corneal basal curvature was 7.4mm.

[0384] Place a dynamic contact lens with a dynamic component above the eye. For example...Figure 15 The dynamic portion 1501 is conformal to the cornea 1502, as shown in the OCT image of

[0385] +3.5D, and the front curvature of the lens is 7.52 mm. This indicates that the optical power of the lens is -5.75D (to correct for -2.25D (required for the uncorrected eye) + 3.5D (additional myopic shift of the lens)).

[0386] The pressure is then removed from the peripheral portion of the dynamic contact lens. The dynamic portion 1501 adopts a non-conformal configuration, as shown in the OCT image of Figure 16 There is a clear gap 1503 between the back surface of the dynamic portion and the cornea 1502. In the non-conformal configuration, the required refractive correction of the eye is -2.75D, indicating that the tear lens 1503 adds optical power of +6.25D (+3.5D plus the 2.75D hyperopic shift) to the optical system.

[0387] Example 4

[0388] Tear lens formation on a human eye

[0389] A dynamic contact lens provided by the present disclosure is applied to a human eye.

[0390] Figure 17A A tear reservoir 1701 with a height of 76 pm in the primary gaze is shown. The region of the human eye imaged with OCT is identified by the section Figure 17B

[0391] Example 5

[0392] Paracentral dynamic portion

[0393] A dynamic contact lens with a dynamic portion is applied to a human cornea. The dynamic portion 1003 is located in the paracentral region of the dynamic contact lens. As shown in Figure 10 The non-conformal dynamic portion is located in the paracentral region of the lens center. In the conformal configuration, the dynamic portion would add positive optical power to the eye.

[0394] Example 6

[0395] Example dynamic contact lens configurations and dimensions

[0396] Figures 18-20 Examples of dynamic contact lens configurations and dimensions are shown in

[0397] Figure 18 ​A dynamic contact lens with a peripheral 360° groove with an open path / edge that bulges towards the center is shown. The dynamic lens is designed such that when the lower eyelid exerts pressure on a portion of the groove, tear fluid can be directed to the center.

[0398] Figure 19 A dynamic contact lens with six (6) tear bladders in the peripheral portion with an open path / edge that bulges towards the center is shown. The dynamic lens is designed such that when the lower eyelid exerts pressure on a portion of the groove, tear fluid can be directed to the center.

[0399] Figure 20 A dynamic contact lens with a peripheral 360° groove with a size similar to the size of the dynamic portion is shown.

[0400] Example 7

[0401] Negative lenses with a dynamic portion

[0402] Figure 21 An OCT image of a central dynamic portion 2101 of a negative tear lens 2102 is shown. The thickness of the dynamic portion decreases towards the center of the dynamic portion. Figure 22 A negative tear lens 2202 is shown, where the center of the lens is conformal to the cornea 2203. The thickness of the center of the dynamic portion is less than the thickness at the transition zone with the peripheral portion.

[0403] Example 8

[0404] Influence of lens parameters on the internal force, see Example 11 below

[0405] Figures 25A-25C The effect of the preformed shape of the dynamic portion on the shape of the dynamic portion when applied to a patient’s eye is shown in the middle.

[0406] Figure 25A The relationship between the gap between the back surface of the dynamic portion and the cornea and the preformed SAG height of the dynamic portion is shown.

[0407] For example, with reference to Figure 25A For a dynamic contact lens made of a silicone hydrogel with a Young’s modulus of 0.76 MPa, and with a preformed central SAG height of about 100 pm over a 3 mm diameter (equivalent to a 4.72 mm radius of curvature), when applied to an eye with a 7.6 mm front curvature, the gap between the back surface and the cornea at the center of the dynamic portion is about 10 pm. The gap height is a balance between the restoring force from the preformed SAG height and the availability of tear fluid. The gap height will depend on the availability of tear fluid. For example, as Figure 25AThe gap height is only about 10% of the preformed SAG height, as shown in the middle. With additional tear fluid, the gap height can be as high as 100% of the preformed SAG height. The availability of tear fluid can be controlled and / or facilitated by including fluid reservoirs, channels, fenestrations, and other physical features that aid in the exchange of tear fluid with the tear lens within the gap defined by the dynamic portion. The dynamic lens has a diameter of 14.5 mm, with a dynamic portion of 3 mm in diameter, a central thickness of 200 μιη, and is made of silicone hydrogel.

[0408] Figure 25B An OCT image of a dynamic contact lens made of silicone hydrogel with a Young's modulus of 0.76 MPa, with a preformed SAG height of 40 μιη on a 3 mm diameter (equivalent to a 6.19 mm radius of curvature), on an eye with an anterior curvature of 7.6 mm, and with a tear lens having a gap height of 37 μιη is shown.

[0409] Figure 25C An OCT image of a dynamic contact lens made of silicone hydrogel with a Young's modulus of 0.76 MPa, with a preformed SAG height of 100 μιη on a 3 mm diameter (equivalent to a 4.72 mm radius of curvature), on an eye with an anterior curvature of 7.6 mm, and with a tear lens having a gap height of 96 μιη is shown.

[0410] To create the tear lens shown in Figure 25B and Figure 25C , tear fluid is provided under the peripheral portion and allowed to flow under the dynamic portion to form the tear lens. Both images demonstrate that the dynamic lens can achieve its full preformed potential SAG, thereby creating a tear lens under the entire preformed SAG. Thus, using a soft contact lens material, and if the dynamic lens has a radius of curvature less than the preformed central dynamic portion of the peripheral or peri-peripheral portion, a gap height greater than 10 μιη will be formed between the dynamic portion and the cornea. See also the illustration in Figure 25A . Furthermore, when more tear fluid is available to form the tear lens between the dynamic portion and the cornea, the dynamic portion can arch further away from the cornea.

[0411] The availability of tear fluid can depend on several factors, including the geometry of the lens, features that promote tear fluid flow or exchange (e.g., reservoirs, channels, and fenestrations), the preformed SAG height, and the pressure exerted by the eyelid on the lens. Dynamic contact lenses having a preformed SAG height (distance between the back surface of the dynamic portion at the center of the lens and the base curvature of the peripheral portion) of 60 μιη to 110 μιη were fabricated, applied to the eye, and the gap between the back surface of the dynamic portion and the cornea was measured. The relationship between the preformed SAG height and the gap height reflects the internal mechanical forces induced by the preformed dome on the geometry of the quasi-stable non-conformal configuration. The greater the preformed SAG height, the greater the pumping force generated.

[0412] The internal mechanical forces can also be increased by increasing the thickness of the dynamic portion, by decreasing the diameter of the dynamic portion, and by increasing the Young's modulus of the material forming the dynamic portion. These effects are illustrated in Figures 26A-26C , which shows a plot of the measured gap between the back surface of the center of the dynamic portion and the cornea versus the preformed SAG height for dynamic portions having a thickness of 200 μιη Figure 26A ), 250 μιη Figure 26B ), and 300 μιη Figure 26C . It can be appreciated that Figures 26A-26C represents a dynamic portion having an increasingly greater stiffness.

[0413] As the preformed thickness of the dynamic portion increases, the internal forces increase and the gap height increases. The modulus of the silicone hydrogel lens was 0.76 MPa, the lens diameter was 14.5 mm, the dynamic portion diameter was 3 mm, and the base curvature was 8.9. The preformed SAG height varied from 50 μιη to 250 μιη for each dynamic portion thickness.

[0414] Example 9

[0415] Dynamic lenses with peripheral ridges

[0416] Figure 27 A cross-sectional schematic of a dynamic contact lens having a ridge on the front surface of the peripheral portion is shown in Figure 27 . The dynamic lens shown in includes a dynamic portion 2401 having a thickness of 300 μιη and a preformed SAG height 2402 of 100 μιη, a cavity 2403 in the peripheral portion 2405, and a protrusion 2404 covering the cavity 2403 having various thicknesses up to 350 μιη.

[0417] Figure 28 A photo of a lens placed on an eye is shown in FIG. 1. Figure 28 A photo of a dynamic contact lens with haptics glued on the eye is shown (top left), and a schematic cross-section of a dynamic lens on a cornea 2801 including a dynamic portion 2802, a peripheral portion 2803, haptics 2804, and an eyelid 2805 is shown (bottom right).

[0418] A dynamic lens with peripheral haptics was placed on a human eye and imaged by OCT during primary (forward) gaze Figure 29 ) and downward gaze Figure 30 ). During primary gaze, the dynamic portion was conformal to the cornea, while during downward gaze, the dynamic portion bulged outward to form a tear lens with a gap height of 16 pm. In another embodiment, as shown in FIG. 2, for a dynamic lens with pre-fabricated haptics, the tear lens gap was 38 pm. Figure 31

[0419] Example 10

[0420] Dynamic lenses with flat periphery

[0421] A dynamic lens was fabricated with the following parameters: material type: SH65 silicone hydrogel; material modulus: 200 MPa; center thickness (CT): 200 pm; R0-OZ optic zone: 1.5 pm; SAG (sagittal add power): 110 pm; R1 (near peripheral zone) 4.5 pm; BC1 (near peripheral back curve): 8.9 pm; R2 (lens overall diameter: 14.5 pm; BC2 (far peripheral back curve): 11 pm; transition radius (fillet between OZ and near peripheral): 1 pm; and edge shape: chiseled. In such a dynamic lens, the radius of curvature of the peripheral portion is greater than in other dynamic lenses (flatter profile).

[0422] Figure 32 Flattening the peripheral profile to a base curve of 11 mm was shown to result in an increased gap between the back surface of the dynamic portion and the cornea.

[0423] Example 11

[0424] Dynamic contact lens design

[0425] In general, the structure of the dynamic lens is based on the nominal lens geometry design common in the field of soft contact lenses, such that at least the peripheral portion is conformal to the cornea to achieve comfort and fluid flow under the lens.

[0426] ​A nominal dynamic contact lens can have an average back optical zone radius (BOZR) similar to the corneal front curvature (7 mm to 9 mm), which can be uniform (same BOZR for all lens diameters, e.g., 8.9 mm) or different BOZRs (for different lens diameters) to enhance the lens' ability to conform to the cornea / scleral concave-convex.

[0427] A nominal dynamic lens, for example, can have two peripheral curvatures, 7.86 mm (+- 1.5 mm) central BOZR for a 10 mm (+- 1.5 mm) central diameter, and a flatter 9.3 mm (+- 1.5 mm) BOZR in the periphery. The transition between the two BOZR curvatures can be smoothed by a continuous gradual change or can employ a chamfer. The dynamic lens can have a standard diameter (about 14 mm), be made of a standard soft contact lens material (e.g., silicone hydrogel), and can have a standard optical clarity. The dynamic contact lens can have a standard edge, such as a round edge or a chiseled edge.

[0428] The diameter of the dynamic portion of the dynamic lens, for example, can be from 1 mm to 7 mm, e.g., from 2 mm to 4 mm. The dynamic lens can be manufactured such that the profile is characterized by different curvatures. For example, the central dynamic portion can be manufactured to have a steeper base curve, e.g., convex, such that the SAG height between the center of the dynamic portion and the surface of the surrounding curvature is from 10 pm to 200 pm. The transition between the two curvatures, i.e., the transition zone between the curvature of the dynamic portion and the peripheral portion, can be smoothed by one or more transition curvatures or chamfers to eliminate or minimize local pressure points and to facilitate fluid exchange with the tear lens underneath the dynamic portion. Parameters that facilitate the ability of the dynamic portion to deform include, for example, thickness, material modulus, overall lens geometry, area and diameter of the dynamic portion, and base curve of the dynamic portion.

[0429] A groove on the back surface of the lens (to release pressure from the dynamic portion and allow fluid availability) can be engraved on the transition zone between the dynamic portion and the peripheral portion, for example, having a width of 50 pm to 1000 pm. The groove can span the transition zone between the dynamic portion and the surrounding peripheral portion. The number of grooves, for example, can range from 1 to 12, and the length of the groove, for example, can range from 0.5 mm to the lens edge of the dynamic lens (about 7 mm).

[0430] One or more of the grooves can be connected to a cavity, to one or more fenestrations, or to a cavity and one or more fenestrations.

[0431] Assuming the central curvature of the cornea is 7.6 mm, a lens with a power of 4 diopters would require a SAG of 14 pm over an optical zone of 3 mm in diameter, or a SAG of 26 pm for an optical zone of 4 mm in diameter, or a SAG of 41 pm for an optical zone of 5 mm in diameter.

[0432] Table 1 shows the calculated power resulting from different preformed SAG heights of 40 pm or 100 pm for optical zones of diameters from 3 mm to 5.8 mm, assuming that the tear lens gap is equivalent to the preformed SAG height.

[0433] Table 1. Calculated power

[0434]

[0435] Various aspects of the present invention

[0436] 1A. A contact lens comprising a dynamic portion, wherein the dynamic portion comprises: a conformal configuration configured to provide a first optical power to an eye having a cornea; and at least one non-conformal configuration configured to provide a second optical power to the eye, wherein the second optical power is different than the first optical power.

[0437] 2A. The contact lens of aspect 1A, wherein the contact lens comprises a central geometric axis; and the dynamic portion is disposed at the central geometric axis, near central to the central geometric axis, off central to the central geometric axis, or a combination of any of the foregoing.

[0438] 3A. The contact lens of any one of aspects 1A to 2A, wherein the conformal configuration is configured to substantially conform to the cornea.

[0439] 4A. The contact lens of any one of aspects 1A to 3A, wherein the conformal configuration is configured to adhere to the cornea.

[0440] 5A. The contact lens of any one of aspects 1A to 4A, wherein the conformal configuration is configured to adhere to the cornea by capillary forces.

[0441] 6A. The contact lens of any one of aspects 1A to 5A, wherein the at least one non- conformal configuration comprises a single non-conformal configuration, one or more discrete non-conformal configurations, or a continuous range of non-conformal configurations.

[0442] 7A. The contact lens of any one of aspects 1A to 6A, wherein the at least one non- conformal configuration is configured to provide a tear lens between a posterior surface of the dynamic portion and an anterior surface of the cornea.

[0443] In an 8thA aspect, the contact lens of any of the 1stA through 7thA aspects, wherein the contact lens is configured such that, when applied to a cornea, the dynamic portion assumes the conformal configuration for a first vision and assumes the at least one non-conformal configuration for a second vision.

[0444] In a 9thA aspect, the contact lens of the 8thA aspect, wherein each of the first vision and the second vision independently comprises distance vision, intermediate vision, or near vision.

[0445] In a 10thA aspect, the contact lens of any of the 1stA through 9thA aspects, further comprising at least one first mechanism configured to cause a change between the conformal configuration and the at least one non-conformal configuration; and at least one second mechanism configured to cause a change between the at least one non-conformal configuration and the conformal configuration.

[0446] In an 11thA aspect, the contact lens of the 10thA aspect, wherein the at least one first mechanism, the at least one second mechanism, or both the at least one first mechanism and the at least one second mechanism comprise manipulating one or more tear reservoirs; the one or more tear reservoirs are disposed between a back surface of the dynamic portion and an anterior surface of the cornea; and the one or more tear reservoirs are fluidically coupled to tears between the back surface of the dynamic portion and the anterior surface of the cornea.

[0447] In a 12thA aspect, the contact lens of the 11thA aspect, wherein the one or more tear reservoirs are symmetrically disposed about the dynamic portion.

[0448] In a 13thA aspect, the contact lens of the 11thA aspect, wherein the one or more tear reservoirs are asymmetrically disposed about the dynamic portion.

[0449] In a 14thA aspect, the contact lens of any of the 1stA through 13thA aspects, wherein at least some of the one or more tear reservoirs are compressible.

[0450] In a 15thA aspect, the contact lens of any of the 1stA through 14thA aspects, wherein at least some of the one or more tear reservoirs are compressible by a force in a range from 0.1 gm force to 10 gm force.

[0451] In a 16thA aspect, the contact lens of any of the 1stA through 15thA aspects, wherein the one or more tear reservoirs are configured to compress when pressure is applied by an eyelid; and the one or more tear reservoirs are configured to expand when pressure is not applied by the eyelid.

[0452] Aspect 17A. A contact lens as described in any one of aspects 1A to 16A, wherein the one or more tear reservoirs are configured to compress only when pressure is applied to the eyelids during gaze changes.

[0453] Aspect 18A. A contact lens as described in any one of aspects 1A to 17A, wherein the one or more tear reservoirs are adjacent to the dynamic portion.

[0454] Aspect 19A. A contact lens as described in aspect 10A, wherein the at least one first mechanism, the at least one second mechanism, or both the at least one first mechanism and the at least one second mechanism include exchanging tears by compressing the dynamic portion or the peripheral portion when pressure is applied to the contact lens by the eyelid during a gaze change.

[0455] Aspect 20A. A contact lens as described in aspect 10A, wherein the at least one first mechanism, the at least one second mechanism, or both the at least one first mechanism and the at least one second mechanism include a protrusion located on the front surface of the contact lens, the protrusion being configured to interact with the eyelid.

[0456] Aspect 21A. The contact mirror as described in any one of aspects 1A to 20A further includes an optical region, wherein the dynamic portion overlaps with at least a portion of the optical region.

[0457] Aspect 22A. The contact lens as described in any one of aspects 1A to 21A further includes a peripheral portion coupled to the dynamic portion, wherein the peripheral portion is configured to hold the contact lens on the cornea.

[0458] Aspect 23A. The contact mirror as described in any one of Aspects 1A to 22A, wherein the dynamic portion comprises a first material characterized by a first modulus; and the peripheral portion comprises a second material characterized by a second modulus.

[0459] Aspect 24A. The contact mirror as described in aspect 23A, wherein the first material and the second material comprise the same material.

[0460] Aspect 25A. The contact mirror as described in aspect 23A, wherein the first material and the second material do not include the same material.

[0461] Aspect 26A. The contact mirror as described in any one of aspects 1A to 25A, wherein the first modulus is greater than the second modulus.

[0462] Aspect 27A. The contact mirror as described in any one of aspects 1A to 25A, wherein the first modulus is less than the second modulus.

[0463] Aspect 28A. The contact lens of any one of Aspects 1A to 25A, wherein the first modulus is the same as the second modulus.

[0464] Aspect 29A. The contact lens of any one of Aspects 1A to 28A, wherein the first modulus is in a range from 0.05 MPa to 10 MPa; and the second modulus is in a range from 0.05 MPa to 10 MPa.

[0465] Aspect 30A. The contact lens of any one of Aspects 1A to 29A, wherein the first modulus is in a range from 0.01 MPa to 2 MPa; and the second modulus is in a range from 0.01 MPa to 2 MPa.

[0466] Aspect 31A. The contact lens of any one of Aspects 1A to 30A, wherein each of the first material and the second material independently comprises a silicone, a hydrogel, a silicone hydrogel, or a combination of any of the foregoing.

[0467] Aspect 32A. The contact lens of any one of Aspects 1A to 31A, wherein, in the at least one non-conformal configuration, the dynamic portion comprises a central SAG height in a range from 5 pm to 300 pm relative to a base curvature of a back surface of the peripheral portion.

[0468] Aspect 33A. The contact lens of any one of Aspects 1A to 32A, wherein the dynamic portion comprises a central thickness in a range from 30 pm to 600 pm.

[0469] Aspect 34A. The contact lens of any one of Aspects 1A to 33A, wherein the contact lens comprises a back surface; and at least a portion of the back surface comprises a material, a surface treatment, or a combination thereof; selected to control a capillary force between at least a portion of the back surface of the contact lens and tear fluid, between a cornea and tear fluid, between the back surface of the contact lens and a cornea, or a combination of any of the foregoing.

[0470] Aspect 35A. The contact lens of any one of Aspects 1A to 34A, wherein the first optical power does not provide an optical power change to an eye; or the second optical power does not provide an optical power change to an eye.

[0471] Aspect 36A. The contact lens of any one of Aspects 1A to 35A, wherein the conformal configuration provides a first optical power change to an eye; and the at least one non-conformal configuration provides a second optical power change to an eye in addition to the first optical power change.

[0472] In a 37th A aspect, the contact lens of any of the 1st A to 36th A aspects, wherein at least one of the conformal configuration and the at least one non-conformal configuration is quasi-stable.

[0473] In a 38th A aspect, the contact lens of any of the 1st A to 37th A aspects, wherein the dynamic portion includes a back surface and includes a gap profile between the back surface and the cornea, wherein the gap profile includes a maximum gap difference, wherein the maximum gap difference is a difference between a central gap height and a gap height at a perimeter of the dynamic portion; the conformal configuration includes a first maximum gap difference; the non-conformal configuration includes a second maximum gap difference; and the second maximum gap difference is greater than the first maximum gap difference.

[0474] In a 39th A aspect, the contact lens of any of the 1st A to 38th A aspects, wherein the contact lens includes a preformed shape; and the contact lens includes the preformed shape in one of the at least one non-conformal configuration.

[0475] In a 40th A aspect, the contact lens of any of the 1st A to 39th A aspects, wherein the contact lens includes a peripheral portion including a peripheral back surface; the peripheral back surface includes a peripheral base curvature; the dynamic portion includes a dynamic back surface; the dynamic back surface includes a dynamic base curvature; in the conformal configuration, the dynamic base curvature is substantially the same as the peripheral base curvature; and in the at least one non-conformal configuration, the dynamic base curvature deviates from the peripheral base curvature.

[0476] In a 41st A aspect, the contact lens of any of the 1st A to 40th A aspects, wherein the cornea includes a corneal curvature; the dynamic portion includes a dynamic back surface; the dynamic back surface includes a dynamic base curvature; and in the conformal configuration, the dynamic base curvature is substantially the same as the corneal curvature.

[0477] In a 42nd A aspect, the contact lens of any of the 1st A to 41st A aspects, wherein the contact lens includes a peripheral portion including a peripheral back surface; the peripheral back surface includes a peripheral base curvature; the dynamic portion includes a central SAG height relative to the peripheral base curvature; and the dynamic portion is configured to assume a first configuration characterized by a first central SAG height relative to the peripheral base curvature and to assume a second configuration characterized by a second central SAG height relative to the peripheral base curvature, wherein the first central SAG height and the second central SAG height are not the same.

[0478] Aspect 43A. A contact lens comprising: a peripheral portion comprising a peripheral back surface and a peripheral front surface, wherein the peripheral back surface comprises a peripheral base curve; and a dynamic portion comprising a dynamic back surface and a dynamic front surface, wherein at least the dynamic back surface is convex from the peripheral base curve toward the dynamic front surface.

[0479] Aspect 44A. A contact lens comprising: a dynamic portion comprising a dynamic back surface, wherein the dynamic back surface comprises a dynamic base curve; a peripheral portion coupled to the dynamic portion, wherein the peripheral portion comprises a peripheral back surface; and the peripheral back surface comprises a peripheral base curve; wherein, in a first configuration, the dynamic base curve is substantially the same as the peripheral base curve; and in a second configuration, the dynamic base curve deviates from the peripheral base curve.

[0480] Aspect 45A. A contact lens comprising a dynamic portion comprising a dynamic back surface, wherein the dynamic back surface comprises a dynamic base curve; wherein, in a first configuration, the dynamic base curve is substantially the same as a corneal curvature; and in a second configuration, the dynamic base curve deviates from the corneal curvature.

[0481] Aspect 46A. A contact lens comprising: a peripheral portion comprising a peripheral back surface, wherein the peripheral back surface comprises a peripheral base curve; and a dynamic portion coupled to the peripheral portion, wherein the dynamic portion comprises a central thickness, and a central SAG height relative to the peripheral base curve; wherein the dynamic portion is configured to assume a first configuration characterized by a first central SAG height relative to the peripheral base curve, and to assume a second configuration characterized by a second central SAG height relative to the peripheral base curve, wherein the first central SAG height and the second central SAG height are not the same; and the first configuration and the second configuration are quasi-stable.

[0482] Aspect 47A. A contact lens comprising a dynamic portion comprising a back surface, wherein the back surface comprises a dynamic base curve; in a first configuration, the back surface comprises a first base curve; and in a second configuration, the back surface comprises a second base curve.

[0483] Aspect 48A. The contact lens of Aspect 47A, wherein the first configuration is configured to provide a first optical power to an eye having a cornea; and the second configuration is configured to provide a second optical power to the eye.

[0484] Aspect 49A. The contact lens of any one of Aspects 47A to 48A, wherein the first base curve is substantially the same as a corneal curvature.

[0485] 50A. The contact lens of any one of aspects 47A to 49A, further comprising at least one first mechanism configured to cause a change between the first configuration and the second configuration; and at least one second mechanism configured to cause a change between the second configuration and the first configuration.

[0486] 51A. A contact lens comprising: a dynamic portion, wherein the dynamic portion comprises: at least one first non-conformal configuration configured to provide a first optical power to an eye having a cornea; and at least one second non-conformal configuration configured to provide a second optical power to the eye, wherein the second optical power is different than the first optical power; at least one first mechanism configured to cause a change between the first non-conformal configuration and the at least one second non-conformal configuration; and at least one second mechanism configured to cause a change between the at least one second non-conformal configuration and the at least one first non-conformal configuration.

[0487] 52A. A contact lens comprising: a first portion comprising a first back surface, a first front surface opposite the first back surface, and a first material, wherein the first back surface comprises a first radius of curvature; and the first material comprises a first modulus; and a second portion coupled to the first portion, wherein the second portion comprises a second back surface and a second front surface opposite the second back surface, and a second material, wherein the second back surface comprises a second radius of curvature; and the second material comprises a second modulus; and wherein the first radius of curvature is less than the second radius of curvature; and wherein each of the first modulus and the second modulus is in a range from 0.05 MPa to 10 MPa.

[0488] 53A. The contact lens of aspect 52A, wherein the first portion is configured to provide a tear lens when applied to an eye; and the second portion is configured to hold the contact lens on a cornea.

[0489] 54A. The contact lens of any one of aspects 52A to 53A, wherein each of the first modulus and the second modulus is in a range from 0.05 MPa to 3 MPa.

[0490] 55A. The contact lens of any one of aspects 52A to 54A, wherein the first portion comprises a central SAG height in a range from 5 pm to 300 pm relative to the second radius of curvature of the back surface of the peripheral portion.

[0491] Aspect 56A. A contact lens comprising: a first portion comprising a first back surface, a first front surface opposite the first back surface, and a first material, wherein the first material comprises a first modulus; and a peripheral portion coupled to the first portion, wherein the peripheral portion comprises: a peripheral back surface having a base curvature, and a second material comprising a second modulus; and wherein the first back surface is convex forward from the base curvature of the back surface of the peripheral portion; and wherein each of the first modulus and the second modulus is in a range from 0.05 MPa to 10 MPa.

[0492] Aspect 57A. The contact lens of Aspect 56A, wherein each of the first modulus and the second modulus is in a range from 0.05 MPa to 3 MPa.

[0493] Aspect 58A. The contact lens of any one of Aspects 56A to 57A, wherein the first portion comprises a central SAG height in a range from 5 pm to 300 pm relative to the base curvature of the back surface of the peripheral portion.

[0494] Aspect 59A. A method of correcting vision in a patient comprising applying to an eye of a patient in need of correction of vision a contact lens of any one of Aspects 1A to 51A.

[0495] Aspect 60A. The method of Aspect 59A, wherein correcting vision comprises correcting hyperopia, correcting myopia, correcting astigmatism, or correcting presbyopia.

[0496] Aspect 61A. The method of Aspect 59A, wherein correcting vision comprises delaying progression of myopia.

[0497] Aspect 62A. A method of treating presbyopia comprising applying to an eye of a patient having presbyopia a contact lens of any one of Aspects 1A to 51A.

[0498] Aspect 63A. A method of correcting vision in a patient comprising applying to an eye of a patient in need of such treatment a contact lens of any one of Aspects 52A to 58A.

[0499] Aspect 64A. The method of Aspect 63A, wherein correcting vision comprises treating irregular corneas or astigmatism.

[0500] Aspect 65A. A method of treating an eye of a patient following an ophthalmic treatment comprising applying to an eye of a patient in need of such treatment a contact lens of any one of Aspects 52A to 58A.

[0501] Aspect 66A. A method of treating a wound in the cornea of an eye of a patient, comprising applying to the eye of a patient in need of such treatment a contact lens as in any of Aspects 52A to 58A.

[0502] Aspect 67A. A method of protecting an eye of a patient from potential harm, comprising applying to the eye of a patient in need of such protection a contact lens as in any of Aspects 52A to 58A.

[0503] Aspect 68A. A method of manufacturing a contact lens, comprising shaping a material to provide a contact lens comprising: a peripheral portion comprising a peripheral back surface and a peripheral front surface, wherein the peripheral back surface comprises a peripheral base curvature; and a dynamic portion comprising a dynamic back surface and a dynamic front surface, wherein at least the dynamic back surface is convex from the peripheral base curvature toward the dynamic front surface.

[0504] Aspect 1. A dynamic contact lens comprising: a dynamic portion comprising a dynamic back surface and a dynamic front surface opposite the dynamic back surface; a peripheral portion comprising a peripheral back surface, a peripheral front surface opposite the peripheral back surface, and a transition zone coupling the peripheral portion and the dynamic portion; wherein the dynamic portion comprises: a material having a Young’s modulus ranging from 0.05 MPa to 10 MPa; and a preformed central SAG height ranging from 10 pm to 300 pm.

[0505] Aspect 2. The dynamic contact lens of Aspect 1, wherein the dynamic contact lens is configured to produce a tear lens for correcting vision when applied to a cornea.

[0506] Aspect 3. The dynamic contact lens of any of Aspects 1 to 2, wherein the dynamic portion is capable of assuming two or more quasi-stable configurations when the dynamic contact lens is applied to a cornea, wherein the two or more quasi-stable configurations are characterized by different gaps between the central dynamic back surface and the cornea.

[0507] Aspect 4. The dynamic contact lens of any of Aspects 1 to 3, wherein the dynamic portion has a diameter ranging from 2.5 mm to 7 mm.

[0508] Aspect 5. The dynamic contact lens of any of Aspects 1 to 4, wherein the dynamic back surface has a radius of curvature ranging from 3 mm to 7.5 mm.

[0509] Aspect 6. The dynamic contact lens of any of Aspects 1 to 5, wherein the dynamic portion has a substantially uniform thickness.

[0510] In some embodiments, the dynamic portion has a substantially uniform thickness from 20 pm to 300 pm.

[0511] In some embodiments, the transition zone is configured to facilitate tear flow to a tear lens formed between the dynamic posterior surface and a cornea when applied to an eye.

[0512] In some embodiments, the transition zone includes a feature configured to enhance flexibility of the dynamic portion.

[0513] In some embodiments, the feature includes a smooth edge, a thinned cross-sectional thickness, a groove, or a combination of any of the foregoing.

[0514] In some embodiments, the dynamic contact lens includes one or more channels in the peripheral posterior surface extending from the dynamic portion.

[0515] In some embodiments, each of the one or more channels extends radially from the dynamic portion.

[0516] In some embodiments, the one or more channels include from 3 to 20 channels.

[0517] In some embodiments, each of the one or more channels has a width from 100 pm to 1000 pm and a height from 50 pm to 200 pm.

[0518] In some embodiments, each of the one or more channels has a length from 1 mm to 7 mm.

[0519] In some embodiments, at least one of the channels is coupled to one or more fenestrations extending from the peripheral anterior surface.

[0520] In some embodiments, the one or more fenestrations have a diameter from 200 pm to 600 pm.

[0521] In some embodiments, the dynamic contact lens further includes one or more cavities in the peripheral posterior surface.

[0522] Aspect 19. The dynamic contact lens of aspect 18, wherein the peripheral posterior surface comprises from 3 to 12 cavities.

[0523] Aspect 20. The dynamic contact lens of any one of aspects 18 to 19, wherein each of the one or more cavities independently has a depth from 10 pm to 500 pm below the posterior peripheral surface.

[0524] Aspect 21. The dynamic contact lens of any one of aspects 1 to 20, further comprising one or more protrusions, the one or more protrusions covering the peripheral anterior surface.

[0525] Aspect 22. The dynamic contact lens of aspect 21, wherein the peripheral anterior surface comprises from 3 to 12 protrusions.

[0526] Aspect 23. The dynamic contact lens of any one of aspects 21 to 22, wherein each of the one or more protrusions independently has a height from 10 pm to 200 pm above the anterior peripheral surface.

[0527] Aspect 24. A dynamic contact lens comprising: a peripheral portion, a dynamic portion coupled to the peripheral portion, wherein the dynamic portion comprises: a conformal configuration configured to provide a first optical power to an eye having a cornea; and at least one non-conformal configuration configured to provide a second optical power to the eye, wherein the second optical power is different from the first optical power.

[0528] Aspect 25. The dynamic contact lens of aspect 24, wherein, when applied to the eye, in the conformal configuration, the dynamic portion is substantially conformal to an anterior surface of the cornea; and in the non-conformal configuration, the dynamic portion is not conformal to the anterior surface of the cornea.

[0529] Aspect 26. The dynamic contact lens of any one of aspects 24 to 25, wherein the conformal configuration and the non-conformal configuration are quasi-stable.

[0530] Aspect 27. The dynamic contact lens of any one of aspects 24 to 26, wherein the dynamic contact lens comprises a central geometric axis; and the dynamic portion is disposed at the central geometric axis, near the central geometric axis, off the central geometric axis, or a combination of any of the foregoing.

[0531] Aspect 28. The dynamic contact lens of any one of aspects 24 to 27, wherein, when applied to the eye, in the conformal configuration, the dynamic portion is substantially conformal to the cornea.

[0532] In some embodiments, the dynamic portion is configured to adopt the at least one non-conformal configuration when the dynamic contact lens is applied to the eye.

[0533] In some embodiments, the dynamic portion is configured to adopt the at least one non-conformal configuration when the dynamic contact lens is applied to the eye.

[0534] In some embodiments, the dynamic portion is configured to adopt the at least one non-conformal configuration when the dynamic contact lens is applied to the eye.

[0535] In some embodiments, the at least one non-conformal configuration comprises a single non-conformal configuration, one or more discrete non-conformal configurations, or a continuous range of non-conformal configurations.

[0536] In some embodiments, the at least one non-conformal configuration is configured to provide a tear lens between a posterior surface of the dynamic portion and an anterior surface of the cornea.

[0537] In some embodiments, the dynamic contact lens is configured such that, when applied to the cornea, the dynamic portion adopts the conformal configuration for a first vision and adopts the at least one non-conformal configuration for a second vision.

[0538] In some embodiments, each of the first vision and the second vision independently comprises distance vision, intermediate vision, or near vision.

[0539] In some embodiments, the dynamic contact lens further comprises at least one first feature configured to induce a change between the conformal configuration and the at least one non-conformal configuration; wherein the at least one comprises a preformed geometry of the dynamic portion.

[0540] In some embodiments, the geometry of the dynamic portion comprises a protrusion extending anteriorly from the peripheral portion.

[0541] In some embodiments, the dynamic contact lens further comprises at least one first feature configured to induce a change between the conformal configuration and the at least one non-conformal configuration, and at least one second feature configured to induce a change between the at least one non-conformal configuration and the conformal configuration.

[0542] Aspect 39. The dynamic contact lens of aspect 38, wherein each of the first feature and the second feature is configured to induce a change in conformation by pressure applied by an eyelid.

[0543] Aspect 40. The dynamic contact lens of aspect 39, wherein the pressure applied by an eyelid comprises looking downward, normal blinking, intentional blinking, holding the eyelid closed for a period of time, or squeezing the eyelid against the eye for a period of time.

[0544] Aspect 41. The dynamic contact lens of any one of aspects 38 to 40, wherein the at least one first feature and the at least one second feature are the same feature.

[0545] Aspect 42. The dynamic contact lens of aspect 24, further comprising at least one feature configured to induce a change in conformation by pressure applied by an eyelid.

[0546] Aspect 43. The dynamic contact lens of aspect 42, wherein the at least one feature comprises one or more protrusions located on the anterior surface of the dynamic contact lens.

[0547] Aspect 44. The dynamic contact lens of aspect 43, wherein the one or more protrusions have a height ranging from 10 pm to 200 pm relative to the anterior surface.

[0548] Aspect 45. The dynamic contact lens of any one of aspects 43 to 44, wherein the one or more protrusions are disposed over an underlying cavity in the posterior surface of the dynamic contact lens.

[0549] Aspect 46. The dynamic contact lens of any one of aspects 43 to 44, wherein the one or more protrusions comprise one or more ridges.

[0550] Aspect 47. The dynamic contact lens of any one of aspects 42 to 46, wherein the at least one feature comprises one or more features configured to increase friction.

[0551] Aspect 48. The dynamic contact lens of aspect 47, wherein the one or more features configured to increase friction comprise grooves, dimples, fenestrations, ridges, or a combination of any of the foregoing.

[0552]

[0553]

[0554]

[0555]

[0556]

[0557]

[0558]

[0559]

[0560]

[0561] ​​​​​​​​​Aspect 58. The dynamic contact lens of any one of Aspects 36 to 56, wherein the at least one first feature, the at least one second feature, or both the at least one first feature and the at least one second feature comprise a protrusion on an anterior surface of the dynamic contact lens, the protrusion configured to interact with an eyelid.

[0562] Aspect 59. The dynamic contact lens of any one of Aspects 24 to 58, further comprising an optical zone, wherein the dynamic portion overlaps at least a portion of the optical zone.

[0563] Aspect 60. The dynamic contact lens of any one of Aspects 24 to 59, wherein the peripheral portion is configured to hold the dynamic contact lens on a cornea.

[0564] Aspect 61. The dynamic contact lens of any one of Aspects 24 to 60, wherein the dynamic portion comprises a first material characterized by a first Young’s modulus; and the peripheral portion comprises a second material characterized by a second Young’s modulus.

[0565] Aspect 62. The dynamic contact lens of Aspect 61, wherein the first material and the second material comprise the same material.

[0566] Aspect 63. The dynamic contact lens of Aspect 61, wherein the first material and the second material comprise different materials.

[0567] Aspect 64. The dynamic contact lens of any one of Aspects 61 and 63, wherein the first modulus is greater than the second Young’s modulus.

[0568] Aspect 65. The dynamic contact lens of any one of Aspects 61 and 63, wherein the first modulus is less than the second Young’s modulus.

[0569] Aspect 66. The dynamic contact lens of Aspect 61, wherein the first modulus is the same as the second Young’s modulus.

[0570] Aspect 67. The dynamic contact lens of Aspect 61, wherein the first Young’s modulus is in a range from 0.05 MPa to 10 MPa; and the second Young’s modulus is in a range from 0.05 MPa to 10 MPa.

[0571] Aspect 68. The dynamic contact lens of Aspect 61, wherein the first Young’s modulus is in a range from 0.01 MPa to 2 MPa; and the second Young’s modulus is in a range from 0.01 MPa to 2 MPa.

[0572]

[0573]

[0574]

[0575]

[0576]

[0577]

[0578]

[0579]

[0580] ​​​​​​​​

[0581]

[0582]

[0583]

[0584]

[0585]

[0586] ​​​​​​Aspect 83. A dynamic contact lens comprising a dynamic portion, wherein the dynamic portion comprises a dynamic back surface; the dynamic back surface comprises a dynamic base curvature; in a first configuration, the dynamic base curvature is substantially the same as a corneal curvature; and in a second configuration, the dynamic base curvature deviates from the corneal curvature.

[0587] Aspect 84. A dynamic contact lens comprising: a peripheral portion, wherein the peripheral portion comprises a peripheral back surface, wherein the peripheral back surface comprises a peripheral base curvature; and a dynamic portion coupled to the peripheral portion, wherein the dynamic portion comprises a center thickness, and a center SAG height relative to the peripheral base curvature; wherein the dynamic portion is configured to assume a first configuration characterized by a first center gap height relative to the peripheral base curvature, and to assume a second configuration characterized by a second center gap height relative to the peripheral base curvature, wherein the first center gap height and the second center gap height are not the same; and the first configuration and the second configuration are quasi-stable.

[0588] Aspect 85. A dynamic contact lens comprising a dynamic portion comprising a back surface, wherein the back surface comprises a dynamic base curvature; in a first configuration, the back surface comprises a first base curvature; and in a second configuration, the back surface comprises a second base curvature.

[0589] Aspect 86. The dynamic contact lens of Aspect 85, wherein the first configuration is configured to provide a first optical power to an eye; and the second configuration is configured to provide a second optical power to an eye.

[0590] Aspect 87. The dynamic contact lens of any one of Aspects 85-86, wherein the first base curvature is substantially the same as a corneal curvature.

[0591] Aspect 88. The dynamic contact lens of any one of Aspects 85-87, further comprising: at least one first mechanism configured to cause a change between the first configuration and the second configuration; and at least one second mechanism configured to cause a change between the second configuration and the first configuration.

[0592] Aspect 89. A dynamic contact lens comprising: a dynamic portion, wherein the dynamic portion comprises: at least one first non-conformal configuration configured to provide a first optical power to an eye having a cornea; and at least one second non-conformal configuration configured to provide a second optical power to the eye, wherein the second optical power is different than the first optical power; at least one first mechanism configured to cause a change between the first non-conformal configuration and the at least one second non-conformal configuration; and at least one second mechanism configured to cause a change between the at least one second non-conformal configuration and the at least one first non-conformal configuration.

[0593] Aspect 90. A dynamic contact lens comprising: a first portion comprising a first back surface, a first front surface opposite the first back surface, and a first material, wherein the first back surface comprises a first radius of curvature; and the first material comprises a first Young’s modulus; and a second portion coupled to the first portion, wherein the second portion comprises a second back surface and a second front surface opposite the second back surface, and a second material, wherein the second back surface comprises a second radius of curvature; and the second material comprises a second Young’s modulus; and wherein the first radius of curvature is less than the second radius of curvature; and wherein each of the first Young’s modulus and the second Young’s modulus independently ranges from 0.05 MPa to 10 MPa.

[0594] Aspect 91. The dynamic contact lens of Aspect 90, wherein the first portion is configured to provide a tear lens when applied to an eye; and the second portion is configured to hold the dynamic contact lens on a cornea.

[0595] Aspect 92. The dynamic contact lens of any one of Aspects 90-91, wherein each of the first Young’s modulus and the second Young’s modulus independently ranges from 0.05 MPa to 3 MPa.

[0596] Aspect 93. The dynamic contact lens of any one of Aspects 90-92, wherein the first portion comprises a central SAG height ranging from 5 pm to 300 pm relative to the second radius of curvature of the back surface of the peripheral portion.

[0597] In a 94th aspect, a dynamic contact lens comprising: a first portion comprising a first back surface, a first front surface opposite the first back surface, and a first material, wherein the first material comprises a first Young’s modulus; and a peripheral portion coupled to the first portion, wherein the peripheral portion comprises: a peripheral back surface having a base curvature, and a second material comprising a second Young’s modulus; and wherein the first back surface is convex forward from the base curvature of the back surface of the peripheral portion; and wherein each of the first Young’s modulus and the second Young’s modulus independently ranges from 0.05 MPa to 10 MPa.

[0598] In a 95th aspect, the dynamic contact lens of the 94th aspect, wherein each of the first Young’s modulus and the second Young’s modulus independently ranges from 0.05 MPa to 3 MPa.

[0599] In a 96th aspect, the dynamic contact lens of any one of aspects 94-95, wherein the first portion comprises a central SAG height ranging from 5 pm to 300 pm relative to the base curvature of the back surface of the peripheral portion.

[0600] In a 97th aspect, a method of correcting vision in a patient comprising applying to an eye of a patient in need of correction of vision the dynamic contact lens of any one of aspects 1-96.

[0601] In a 98th aspect, the method of 97, wherein correcting vision comprises correcting hyperopia, correcting myopia, correcting astigmatism, or correcting presbyopia.

[0602] In a 99th aspect, the method of any one of aspects 97-98, wherein correcting vision comprises retarding progression of myopia.

[0603] In a 100th aspect, a method of treating presbyopia comprising applying to an eye of a patient having presbyopia the dynamic contact lens of any one of aspects 1-96.

[0604] In a 101st aspect, a method of correcting vision in a patient comprising applying to an eye of a patient in need of such treatment the dynamic contact lens of any one of aspects 1-96.

[0605] In a 102nd aspect, the method of 101, wherein correcting vision comprises treating irregular corneas or astigmatism.

[0606] In a 103rd aspect, a method of treating an eye of a patient following an ophthalmic treatment comprising applying to an eye of a patient in need of such treatment the dynamic contact lens of any one of aspects 1-96.

[0607] Aspect 104. A method of treating a wound of the cornea of an eye of a patient, comprising applying to the eye of a patient in need of such treatment a dynamic contact lens as in any of Aspects 1 to 96.

[0608] Aspect 105. A method of protecting an eye of a patient from potential harm, comprising applying to the eye of a patient in need of such protection a dynamic contact lens as in any of Aspects 1 to 96.

[0609] Aspect 106. A method of manufacturing a dynamic contact lens, comprising shaping a material to provide a dynamic contact lens comprising: a peripheral portion comprising a peripheral back surface and a peripheral front surface, wherein the peripheral back surface comprises a peripheral base curvature; and a dynamic portion comprising a dynamic back surface and a dynamic front surface, wherein at least the dynamic back surface is convex from the peripheral base curvature toward the dynamic front surface.

[0610] Aspect 107. The method of Aspect 106, wherein the peripheral portion comprises a first material characterized by a first Young’s modulus; and the dynamic portion comprises a second material characterized by a second Young’s modulus; and wherein each of the first Young’s modulus and the second Young’s modulus is from 0.05 MPa to 30 MPa.

[0611] Aspect 108. The method of any of Aspects 106 to 107, wherein each of the first Young’s modulus and the second Young’s modulus is from 0.01 MPa to 2 MPa.

[0612] Aspect 109. A method of manufacturing a dynamic contact lens, comprising shaping a material to provide a dynamic contact lens comprising: a dynamic portion characterized by a dynamic base curvature; and a peripheral portion coupled to the dynamic portion, wherein the peripheral portion comprises a peripheral base curvature, wherein the dynamic base curvature is different than the peripheral base curvature.

[0613] Aspect 110. The method of Aspect 109, wherein a radius of curvature of the dynamic portion is less than a radius of curvature of the peripheral portion.

[0614] Aspect 111. The method of any of Aspects 109 to 110, wherein a radius of curvature of the dynamic portion is less than a radius of curvature of a paracentral peripheral portion, wherein the paracentral peripheral portion abuts the dynamic portion.

[0615] Aspect 112. A dynamic contact lens as in any of Aspects 1 to 96 applied to a cornea.

[0616] There are alternative means of implementing the embodiments disclosed herein. Therefore, the present embodiments are to be considered as illustrative and not restrictive, and the appended claims are not to be limited to the details given herein, but can be modified within the scope and equivalents of the claims.

Claims

1. A dynamic contact lens comprising: a peripheral portion; one or more fenestrations disposed in the peripheral portion of the dynamic contact lens; and an inboard dynamic portion coupled with the peripheral portion, wherein the inboard dynamic portion is configured to form a cylindrical tear lens with an eye when worn on the eye, the inboard dynamic portion assuming a conformal configuration configured to provide a first optical power to the eye; and at least one non-conformal configuration configured to provide a second optical power to the eye, wherein the second optical power is different from the first optical power; wherein, in the at least one non-conformal configuration, a back surface of the inboard dynamic portion comprises a central gap height ranging from 5 pm to 300 pm relative to a base curvature of a back surface of the peripheral portion; wherein the dynamic contact lens comprises a material having a Young’s modulus ranging from about 0.1 MPa to about 3 MPa; and wherein the dynamic contact lens is configured to correct for astigmatism when worn on the eye.

2. The dynamic contact lens of claim 1, wherein the one or more fenestrations are configured to facilitate a flow of liquid from an anterior surface of the dynamic contact lens to a posterior surface of the dynamic contact lens.

3. The dynamic contact lens of claim 1, further comprising: a transition zone coupling the peripheral portion and the inboard dynamic portion, the transition zone configured to facilitate a transition of the inboard dynamic portion between two or more configurations.

4. The dynamic contact lens of claim 3, wherein the transition zone comprises one or more features configured to enhance a flexibility of the inboard dynamic portion.

5. The dynamic contact lens of claim 4, wherein the one or more features are selected from a smooth edge, a thinned cross-sectional thickness, a groove, or any combination thereof.

6. The dynamic contact lens of claim 2, further comprising: one or more channels located in the posterior surface of the dynamic contact lens, wherein the one or more channels are fluidically coupled to the one or more fenestrations and configured to facilitate a flow of liquid to the inboard dynamic portion.

7. The dynamic contact lens of claim 1, wherein the inboard dynamic portion and peripheral portion have the same base curvature when in a conformal configuration.

8. The dynamic contact lens of claim 1, wherein the inboard dynamic portion and peripheral portion have different base curvatures when in at least one non-conformal configuration.

9. The dynamic contact lens of claim 1, wherein the inboard dynamic portion and peripheral portion are made of the same material.

10. The dynamic contact lens of claim 1, wherein the inboard dynamic portion and peripheral portion are made of one or more materials having the same Young’s modulus.

11. The dynamic contact lens of claim 1, wherein the dynamic contact lens comprises a soft material.

12. The dynamic contact lens of claim 1, wherein the tear lens provides an additional optical power to the eye.

13. A dynamic contact lens comprising: a peripheral portion, one or more fenestrations disposed in the peripheral portion of the dynamic contact lens; ​ a dynamic portion coupled to the peripheral portion, wherein the dynamic portion comprises: a conformal configuration configured to provide a first optical power to an eye having a cornea; and at least one non-conformal configuration configured to provide a second optical power to the eye, wherein the second optical power is different than the first optical power; wherein, in the at least one non-conformal configuration, a back surface of the dynamic portion comprises a central gap height ranging from 5 µm to 300 µm relative to a base curvature of a back surface of the peripheral portion.

14. The dynamic contact lens of claim 13, wherein, when the dynamic contact lens is applied to the eye, in the conformal configuration, the dynamic portion is substantially conformal to an anterior surface of the cornea; and in the non-conformal configuration, the dynamic portion is not conformal to the anterior surface of the cornea.

15. The dynamic contact lens of claim 13, wherein the conformal configuration and the non-conformal configuration are quasi-stable.

16. The dynamic contact lens of claim 13, wherein, the dynamic contact lens comprises a central geometric axis; and the dynamic portion is disposed at, near, or offset from the central geometric axis.

17. The dynamic contact lens of claim 13, wherein, when the dynamic contact lens is applied to the eye, in the conformal configuration, the dynamic portion is substantially conformal to the cornea.

18. The dynamic contact lens of claim 13, wherein, when the dynamic contact lens is applied to the eye, in the conformal configuration, the dynamic portion adheres to the cornea.

19. The dynamic contact lens of claim 13, wherein, when the dynamic contact lens is applied to the eye, in the conformal configuration, the dynamic portion adheres to the cornea by capillary force.

20. The dynamic contact lens of claim 13, wherein, when the dynamic contact lens is applied to the eye, in the conformal configuration, the dynamic portion adheres to the cornea by mechanical force.

21. The dynamic contact lens of claim 13, wherein the at least one non-conformal configuration comprises a single non-conformal configuration, two or more discrete non-conformal configurations, or a plurality of contiguous ranges of non-conformal configurations.

22. The dynamic contact lens of claim 13, wherein the at least one non-conformal configuration is configured to provide a tear lens between a back surface of the dynamic portion and an anterior surface of the cornea.

23. The dynamic contact lens of claim 13, wherein the dynamic contact lens is configured such that, when applied to the cornea, the dynamic portion assumes the conformal configuration for a first vision and assumes the at least one non-conformal configuration for a second vision.

24. The dynamic contact lens of claim 23, wherein each of the first vision and the second vision independently comprises distance vision, intermediate vision, or near vision.

25. The dynamic contact lens of claim 13, further comprising: at least one first feature configured to induce a change between the conformal configuration and the at least one non-conformal configuration; wherein the at least one first feature comprises a preformed geometry of the dynamic portion.

26. The dynamic contact lens of claim 25, wherein the geometry of the dynamic portion comprises a protrusion extending forward from the peripheral portion.

27. The dynamic contact lens of claim 13, further comprising: at least one first feature configured to cause a change between the conformal configuration and the at least one non-conformal configuration; and at least one second feature configured to cause a change between the at least one non-conformal configuration and the conformal configuration.

28. The dynamic contact lens of claim 27, wherein each of the first feature and the second feature is configured to cause a change in configuration by pressure applied by an eyelid.

29. The dynamic contact lens of claim 28, wherein the pressure applied by the eyelid comprises looking downward, normal blinking, intentional blinking, holding the eyelid closed for a period of time, or squeezing the eyelid against the eye for a period of time.

30. The dynamic contact lens of claim 27, wherein the at least one first feature and the at least one second feature are the same feature.

31. The dynamic contact lens of claim 13, further comprising at least one feature configured to cause a change in configuration by pressure applied by an eyelid.

32. The dynamic contact lens of claim 31, wherein the at least one feature comprises one or more protrusions located on an anterior surface of the dynamic contact lens.

33. The dynamic contact lens of claim 32, wherein the one or more protrusions have a height ranging from 10 pm to 200 pm relative to the anterior surface.

34. The dynamic contact lens of claim 32, wherein the one or more protrusions are disposed over an underlying cavity in the posterior surface of the dynamic contact lens.

35. The dynamic contact lens of claim 32, wherein the one or more protrusions comprise one or more ridges.

36. The dynamic contact lens of claim 31, wherein the at least one feature comprises one or more features configured to increase friction.

37. The dynamic contact lens of claim 36, wherein the one or more features configured to increase friction comprise grooves, dimples, fenestrations, ridges, or a combination of any of the foregoing.

38. The dynamic contact lens of claim 27, wherein, the at least one first feature, the at least one second feature, or both the at least one first feature and the at least one second feature comprise one or more tear reservoirs; the one or more tear reservoirs are disposed between a posterior surface of the dynamic portion and an anterior surface of the cornea; and the one or more tear reservoirs are fluidically coupled to tears between the posterior surface of the dynamic portion and the anterior surface of the cornea.

39. The dynamic contact lens of claim 38, wherein the one or more tear reservoirs are symmetrically disposed around the dynamic portion.

40. The dynamic contact lens of claim 38, wherein the one or more tear reservoirs are asymmetrically disposed around the dynamic portion.

41. The dynamic contact lens of claim 38, wherein at least some of the one or more tear reservoirs are compressible.

42. The dynamic contact lens of claim 38, wherein at least some of the one or more tear reservoirs are compressible by a force ranging from 0.1 gm force to 10 gm force.

43. The dynamic contact lens of claim 38, wherein, the one or more tear reservoirs are configured to compress when pressure is applied by an eyelid; and the one or more tear reservoirs are configured to expand when no pressure is applied by an eyelid.

44. The dynamic contact lens of claim 38, wherein the one or more tear reservoirs are configured to compress only when pressure is applied by an eyelid during a gaze change.

45. The dynamic contact lens of claim 38, wherein the one or more tear reservoirs are fluidically coupled to the dynamic portion.

46. The dynamic contact lens of claim 25, wherein the at least one first feature, the at least one second feature, or both the at least one first feature and the at least one second feature comprise exchanging tear fluid by compressing the dynamic portion or compressing the peripheral portion when pressure is applied to the dynamic contact lens by an eyelid during a gaze change.

47. The dynamic contact lens of claim 25, wherein the at least one first feature, the at least one second feature, or both the at least one first feature and the at least one second feature comprise a protrusion on an anterior surface of the dynamic contact lens, the protrusion configured for interaction with an eyelid.

48. The dynamic contact lens of claim 13, further comprising an optical zone, wherein the dynamic portion overlaps at least a portion of the optical zone.

49. The dynamic contact lens of claim 13, wherein the peripheral portion is configured to hold the dynamic contact lens on a cornea.

50. The dynamic contact lens of claim 13, wherein, the dynamic portion comprises a first material characterized by a first Young’s modulus; and the peripheral portion comprises a second material characterized by a second Young’s modulus.

51. The dynamic contact lens of claim 50, wherein, the first material and the second material comprise the same material.

52. The dynamic contact lens of claim 50, wherein, the first material and the second material comprise different materials.

53. The dynamic contact lens of claim 50, wherein, the first Young’s modulus is greater than the second Young’s modulus.

54. The dynamic contact lens of claim 50, wherein, the first Young’s modulus is less than the second Young’s modulus.

55. The dynamic contact lens of claim 50, wherein, the first Young’s modulus is the same as the second Young’s modulus.

56. The dynamic contact lens of claim 50, wherein, the first Young’s modulus is in a range from 0.05 MPa to 10 MPa; and the second Young’s modulus is in a range from 0.05 MPa to 10 MPa.

57. The dynamic contact lens of claim 50, wherein, the first Young’s modulus is in a range from 0.01 MPa to 2 MPa; and the second Young’s modulus is in a range from 0.01 MPa to 2 MPa.

58. The dynamic contact lens of claim 50, wherein each of the first material and the second material independently comprises a silicone, a hydrogel, a silicone hydrogel, or a combination of any of the foregoing.

59. The dynamic contact lens of claim 13, wherein the dynamic portion comprises a central thickness from 30 µm to 600 µm.

60. The dynamic contact lens of claim 13, wherein, the dynamic contact lens comprises a back surface; and at least a portion of the back surface comprises a material, a surface treatment, or a combination thereof; selected to control a capillary force between at least a portion of the back surface of the dynamic contact lens and tear fluid, between a cornea and tear fluid, between the back surface of the dynamic contact lens and a cornea, or a combination of any of the foregoing.

61. The dynamic contact lens of claim 13, wherein, the first optical power does not provide a change in optical power to an eye; or the second optical power does not provide a change in optical power to an eye.

62. The dynamic contact lens of claim 13, wherein, the conformal configuration provides a first change in optical power to an eye; and the at least one non-conformal configuration provides a second change in optical power to an eye other than the first change in optical power.

63. The dynamic contact lens of claim 13, wherein at least one of the conformal configuration and the non-conformal configuration is quasi-stable.

64. The dynamic contact lens of claim 13, wherein, the dynamic portion comprises a back surface and comprises a gap profile between the back surface and a cornea, wherein the gap profile comprises a maximum gap difference, wherein the maximum gap difference is a difference between a central gap height and a gap height at a perimeter of the dynamic portion; the conformal configuration comprises a first maximum gap difference; the non-conformal configuration comprises a second maximum gap difference; and the second maximum gap difference is greater than the first maximum gap difference.

65. The dynamic contact lens of claim 13, wherein, the dynamic contact lens comprises a preformed shape; and the dynamic contact lens comprises the preformed shape in at least one of the conformal configuration and the non-conformal configuration.

66. The dynamic contact lens of claim 13, wherein, the dynamic contact lens comprises a peripheral portion comprising a peripheral back surface; the peripheral back surface comprises a peripheral base curvature; the dynamic portion comprises a dynamic back surface; the dynamic back surface comprises a dynamic base curvature; in the conformal configuration, the dynamic base curvature is substantially the same as the peripheral base curvature; and in the at least one non-conformal configuration, the dynamic base curvature deviates from the peripheral base curvature.

67. The dynamic contact lens of claim 13, wherein, a cornea comprises a corneal curvature; the dynamic portion comprises a dynamic back surface; the dynamic back surface comprises a dynamic base curvature; and in the conformal configuration, the dynamic base curvature is substantially the same as the corneal curvature.

68. The dynamic contact lens of claim 13, wherein, the dynamic contact lens comprises a peripheral portion comprising a peripheral back surface; the peripheral back surface comprises a peripheral base curvature; the dynamic portion comprises a center sagittal (SAG) height relative to the peripheral base curvature; and the dynamic contact lens comprises a peripheral portion comprising a peripheral back surface; the peripheral back surface comprises a peripheral base curvature; the dynamic portion comprises a dynamic back surface; and in the conformal configuration, the dynamic base curvature is substantially the same as the peripheral base curvature; and in the at least one non-conformal configuration, the dynamic base curvature deviates from the peripheral base curvature. The dynamic portion is configured to assume a first configuration characterized by a first central gap height relative to the peripheral base curve and to assume a second configuration characterized by a second central gap height relative to the peripheral base curve, wherein the first central sagittal (SAG) height and the second central gap height are not the same.

69. A dynamic contact lens comprising: a peripheral portion comprising a peripheral back surface and a peripheral front surface, wherein the peripheral back surface comprises a peripheral base curve; and one or more fenestrations disposed in the peripheral portion of the dynamic contact lens; a dynamic portion comprising a dynamic back surface and a dynamic front surface, wherein at least the dynamic back surface is convex from the peripheral base curve toward the dynamic front surface; wherein the dynamic back surface comprises a central gap height ranging from 5 µm to 300 µm relative to the peripheral base curve.

70. A dynamic contact lens comprising: a dynamic portion comprising a dynamic back surface, wherein the dynamic back surface comprises a dynamic base curve; a peripheral portion coupled to the dynamic portion, wherein the peripheral portion comprises a peripheral back surface; and one or more fenestrations disposed in the peripheral portion of the dynamic contact lens; the peripheral back surface comprises a peripheral base curve; wherein, in a first configuration, the dynamic base curve is substantially the same as the peripheral base curve; and in a second configuration, the dynamic base curve deviates from the peripheral base curve; wherein in the second configuration, the dynamic back surface comprises a central gap height ranging from 5 µm to 300 µm relative to the peripheral base curve.

71. A dynamic contact lens comprising: a dynamic portion; a peripheral portion coupled to the dynamic portion; and one or more fenestrations disposed in the peripheral portion of the dynamic contact lens; wherein the dynamic portion comprises a dynamic back surface, wherein the dynamic back surface comprises a dynamic base curve, wherein in a first configuration, the dynamic base curve is substantially the same as a corneal curvature, wherein in a second configuration, the dynamic base curve deviates from the corneal curvature, and wherein in the second configuration, the dynamic back surface comprises a central gap height ranging from 5 µm to 300 µm relative to the corneal curvature.

72. A dynamic contact lens comprising: a peripheral portion, wherein the peripheral portion comprises a peripheral back surface, wherein the peripheral back surface comprises a peripheral base curve; one or more fenestrations disposed in the peripheral portion of the dynamic contact lens; and a dynamic portion coupled to the peripheral portion, wherein the dynamic portion comprises a central thickness, and a central sagittal (SAG) height relative to the peripheral base curve, wherein the dynamic portion is configured to assume a first configuration characterized by a first central gap height relative to the peripheral base curve and to assume a second configuration characterized by a second central gap height relative to the peripheral base curve, wherein the first central gap height and the second central gap height are not the same; and wherein the first configuration and the second configuration are quasi-stable; wherein the central sagittal (SAG) height is in a range from 5 µm to 300 µm.

73. A dynamic contact lens comprising: dynamic a peripheral portion, wherein the peripheral portion comprises a peripheral back surface, wherein the peripheral back surface comprises a peripheral base curvature; and one or more fenestrations disposed in the peripheral portion of the dynamic contact lens, wherein the back surface comprises a dynamic base curvature, in a first configuration, the back surface comprises a first base curvature, and in a second configuration, the back surface comprises a second base curvature; wherein the back surface comprises a central gap height in a range from 5 µm to 300 µm relative to the peripheral base curvature.

74. The dynamic contact lens of claim 73, wherein, the first configuration is configured to provide a first optical power to the eye; and the second configuration is configured to provide a second optical power to the eye.

75. The dynamic contact lens of claim 73, wherein the first base curvature is substantially the same as a corneal curvature.

76. The dynamic contact lens of claim 73, further comprising: at least one first mechanism configured to cause a change between the first configuration and the second configuration; and at least one second mechanism configured to cause a change between the second configuration and the first configuration.

77. A dynamic contact lens, comprising: a dynamic portion, wherein the dynamic portion comprises: at least one first non-conformal configuration configured to provide a first optical power to an eye having a cornea; and at least one second non-conformal configuration configured to provide a second optical power to the eye, wherein the second optical power is different than the first optical power; at least one first mechanism configured to cause a change between the at least one first non-conformal configuration and the at least one second non-conformal configuration; at least one second mechanism configured to cause a change between the at least one second non-conformal configuration and the at least one first non-conformal configuration; a peripheral portion coupled to the dynamic portion; and one or more fenestrations disposed in the peripheral portion of the dynamic contact lens; wherein a back surface of the dynamic portion comprises a central gap height in a range from 5 µm to 300 µm relative to a base curvature of a back surface of the peripheral portion in at least one non-conformal configuration.

78. A dynamic contact lens, comprising: a first portion comprising a first back surface, a first front surface opposite the first back surface, and a first material, wherein the first back surface comprises a first radius of curvature; and the first material comprises a first Young’s modulus; a second portion coupled to the first portion, wherein the second portion comprises a second back surface and a second front surface opposite the second back surface, and a second material; and one or more fenestrations disposed in the second portion of the dynamic contact lens, wherein the second back surface comprises a second radius of curvature; wherein the second material comprises a second Young’s modulus; wherein the first radius of curvature is less than the second radius of curvature; wherein each of the first Young's modulus and the second Young's modulus independently ranges from 0.05 MPa to 10 MPa; and wherein the first back surface comprises a central sagittal (SAG) height ranging from 5 pm to 300 pm relative to a second radius of curvature of a back surface of the second portion.

79. The dynamic contact lens of claim 78, wherein, the first portion is configured to provide a tear lens when applied to an eye; and the second portion is configured to hold the dynamic contact lens on a cornea.

80. The dynamic contact lens of claim 78, wherein each of the first Young's modulus and the second Young's modulus independently ranges from 0.05 MPa to 3 MPa.

81. A dynamic contact lens, comprising: a first portion comprising a first back surface, a first front surface opposite the first back surface, and a first material, wherein the first material comprises a first Young's modulus; and a peripheral portion coupled to the first portion; and one or more fenestrations disposed in the peripheral portion of the dynamic contact lens, wherein the peripheral portion comprises: a peripheral back surface having a base curvature, and a second material comprising a second Young's modulus; and wherein the first back surface is convex forward from the base curvature of the back surface of the peripheral portion; wherein each of the first Young's modulus and the second Young's modulus independently ranges from 0.05 MPa to 10 MPa; and wherein the first back surface comprises a central sagittal (SAG) height ranging from 5 pm to 300 pm relative to the base curvature of the back surface of the peripheral portion.

82. The dynamic contact lens of claim 81, wherein each of the first Young's modulus and the second Young's modulus independently ranges from 0.05 MPa to 3 MPa.

83. A method of manufacturing a dynamic contact lens, comprising shaping a material to provide a dynamic contact lens, the dynamic contact lens comprising: a peripheral portion comprising a peripheral back surface and a peripheral front surface, wherein the peripheral back surface comprises a peripheral base curvature; a dynamic portion comprising a dynamic back surface and a dynamic front surface, wherein at least the dynamic back surface is convex from the peripheral base curvature toward the dynamic front surface; and one or more fenestrations disposed in the peripheral portion of the dynamic contact lens; wherein the dynamic back surface comprises a central gap height ranging from 5 pm to 300 pm relative to the peripheral base curvature.

84. The method of claim 83, wherein, the peripheral portion comprises a first material characterized by a first Young's modulus; and the dynamic portion comprises a second material characterized by a second Young's modulus; and wherein each of the first Young's modulus and the second Young's modulus ranges from 0.05 MPa to 30 MPa.

85. The method of claim 84, wherein each of the first Young's modulus and the second Young's modulus ranges from 0.01 MPa to 2 MPa.

86. A method of manufacturing a dynamic contact lens, comprising shaping a material to provide a dynamic contact lens, the dynamic contact lens comprising: a dynamic portion characterized by a dynamic base curvature; a peripheral portion coupled to the dynamic portion, wherein the peripheral portion comprises a peripheral base curvature; and one or more fenestrations disposed in the peripheral portion of the dynamic contact lens, wherein the dynamic base curvature is different from the peripheral base curvature; and wherein a back surface of the dynamic portion comprises a center clearance height in a range from 5 µm to 300 µm relative to the peripheral base curvature.

87. The method of claim 86, wherein a radius of curvature of the dynamic portion is less than a radius of curvature of the peripheral portion.

88. The method of claim 86, wherein a radius of curvature of the dynamic portion is less than a radius of curvature of a paracentral peripheral portion, wherein the paracentral peripheral portion abuts the dynamic portion.

89. The dynamic contact lens of any one of claims 1 to 82 applied to a cornea.

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