Biological detection device and control method thereof, refrigerator

Abstract

The present application relates to biological detection device and its control method, refrigerator. Biological detection device has drive mechanism and for installing biological detection chip's chip mounting portion, biological detection chip has multiple independent detection channels, the control method of the present application includes: receiving for indicating biological detection chip has been installed to the first trigger signal of chip mounting portion; start drive mechanism, drive fluid flow in each detection channel through drive mechanism simultaneously, thereby allowing multiple detection channels to perform detection operation simultaneously, meet the needs of users to detect multiple different samples or different parameters of the same sample, and the same time as detecting one sample of one detection parameter, shorten the time required for detection, facilitate users to compare and analyze the detection results of multiple detection channels, improve the user experience.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of refrigeration, and particularly relates to a control method of a biological detection device, the biological detection device and a refrigerator. BACKGROUND

[0002] With the improvement of people's living standards, it is usually necessary to detect the pesticide residues, viruses, nutritional elements or other aspects of some food materials in daily life to qualitatively or quantitatively obtain the conditions of the food materials. For example, due to the problem of pesticide abuse, the fruits, vegetables and agricultural and sideline products purchased by us in daily life may have the problem of excessive pesticide residues, and if the problem of excessive pesticide residues of these foods cannot be found in time, it will cause great harm to the human body after being taken in. For another example, the current breastfeeding is the best feeding for infants only when the breast milk has normal nutritional value, however, in the case of illness, taking medicine or surgery of the lactating woman or other conditions, the nutritional element content in the milk secreted by the lactating woman may be reduced or even viruses may be produced, thereby affecting the growth and health of the infant.

[0003] Among many detection methods, the method of using a biological detection chip for detection is relatively fast and small in size, and is suitable for family use. In order to make the sample liquid of the biological detection chip more accurate and convenient to control, a driving mechanism can be used to drive the sample liquid into the biological detection chip. However, the existing driving mechanism can only drive the sample liquid in one detection channel of one biological detection chip to flow, and if the user needs to detect different samples or different parameters of the same sample, the driving mechanism needs to be repeatedly executed for multiple times to perform the same operation, which is complex and time-consuming, and is not convenient for comparison of multiple detection results. SUMMARY

[0004] One object of the first aspect of the present application is to overcome at least one defect of the prior art, and to provide a control method of a biological detection device capable of simultaneously driving fluids in multiple detection channels.

[0005] One further object of the first aspect of the present application is to improve the accuracy of the detection results.

[0006] Another further object of the first aspect of the present application is to improve the accuracy of the sample liquid flow control.

[0007] One object of the second aspect of the present application is to provide a biological detection device operating according to the above control method.

[0008] One object of the third aspect of the present application is to provide a refrigerator having a biological detection device operating according to the above control method.

[0009] According to a first aspect of the present application, the present application provides a control method of a biological detection device, the biological detection device having a driving mechanism and a chip mounting portion for mounting a biological detection chip, the biological detection chip having a plurality of mutually independent detection channels, the control method comprising:

[0010] receiving a first trigger signal for indicating that the biological detection chip has been mounted to the chip mounting portion;

[0011] starting the driving mechanism to simultaneously drive fluid flow in each of the detection channels.

[0012] Optionally, each of the detection channels comprises a sampling chamber for containing an extraction solution; the biological detection device comprises a sample loading structure for pushing a solid sample resting outside each of the sampling chambers into the sampling chamber to soak the solid sample in the extraction solution in the sampling chamber when the biological detection chip is mounted to the chip mounting portion; and

[0013] After receiving the first trigger signal and before starting the driving mechanism, the control method further comprises waiting for a first preset time length.

[0014] Optionally, each of the detection channels further comprises a reaction chamber for containing a reaction reagent and a detection chamber for containing a detection reagent, the sampling chamber, the reaction chamber and the detection chamber of the same detection channel are sequentially communicated under cooperation of the chip mounting portion, and the driving mechanism is communicated with the sampling chamber of each of the detection channels; and

[0015] The step of simultaneously driving fluid flow in each of the detection channels by the driving mechanism comprises:

[0016] controlling the driving mechanism to perform a liquid pushing action to cause sample liquid in the sampling chamber of each of the detection channels to sequentially flow to the reaction chamber and the detection chamber of the detection channel.

[0017] Optionally, the step of controlling the driving mechanism to perform the liquid pushing action specifically comprises:

[0018] causing, by the driving mechanism, sample liquid in the sampling chamber of each of the detection channels to flow to the reaction chamber of the detection channel;

[0019] stopping the driving mechanism;

[0020] after a time length during which the driving mechanism is stopped reaches a second preset time length, starting the driving mechanism again to cause sample liquid in the reaction chamber of each of the detection channels to flow to the detection chamber of the detection channel.

[0021] Optionally, before stopping the driving mechanism, the step of controlling the driving mechanism to perform the liquid pushing action further comprises:

[0022] determining whether the sample liquid flowing into the reaction chamber reaches a preset sample amount;

[0023] If yes, stopping the driving mechanism.

[0024] Optionally, the driving mechanism is an injection pump,

[0025] The step of determining whether the sample liquid flowing into the reaction chamber reaches a preset sample amount comprises:

[0026] detecting the position of the piston of the driving mechanism;

[0027] When the piston moves to the preset position, it is determined that the sample liquid in the reaction chamber reaches the preset sample amount.

[0028] Optionally, after the sample liquid in the reaction chamber of each detection channel is caused to flow to the detection chamber of the detection channel, the control method further comprises:

[0029] waiting for a third preset time length and then sending prompt information for prompting that the detection result has been shown.

[0030] Optionally, the driving mechanism is an injection pump,

[0031] The control method further comprises:

[0032] When a second trigger signal for indicating that the bio-detection chip is removed from the chip mounting portion is received, the piston of the driving mechanism is controlled to return to the initial position.

[0033] According to the second aspect of the present application, the present application further provides a bio-detection device, which operates according to the control method according to any of the above-mentioned schemes.

[0034] According to the second aspect of the present application, the present application further provides a refrigerator comprising a bio-detection device operating according to the control method according to any of the above-mentioned schemes.

[0035] The bio-detection device of the present application has a driving mechanism and a chip mounting portion, and the chip mounting portion is used for mounting a bio-detection chip having a plurality of independent detection channels. When the bio-detection device receives a first trigger signal for indicating that the bio-detection chip has been mounted to the chip mounting portion, the driving mechanism is automatically started, and the fluid in each detection channel is simultaneously driven by the driving mechanism, so that the plurality of detection channels can simultaneously perform detection operations, meeting the needs of users to detect a plurality of different samples or different parameters of the same sample, and the detection time is the same as that of detecting one detection parameter of one sample, the detection time is shortened, the users can compare and analyze the detection results of the plurality of detection channels, and the user experience is improved.

[0036] Furthermore, the present application also precisely controls the amount of sample liquid entering the reaction chamber to match the amount of each reagent in the biological detection chip, avoiding the impact of excessive or insufficient sample liquid on the detection results, thereby improving the accuracy of the detection results.

[0037] Furthermore, the present application also controls the piston of the driving mechanism to return to its initial position upon receiving a second trigger signal for instructing the biological detection chip to be removed from the chip mounting portion, thereby ensuring that the driving mechanism can start moving from the initial position each time a new biological detection chip is installed, avoiding large error accumulation after multiple movements of the driving mechanism, and improving the accuracy of sample liquid flow control.

[0038] Based on the following detailed description of specific embodiments of the present invention in conjunction with the accompanying drawings, those skilled in the art will become more aware of the above and other objects, advantages and features of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0039] Hereinafter, some specific embodiments of the present invention will be described in detail in an exemplary and non-limiting manner with reference to the accompanying drawings. The same reference numerals in the accompanying drawings indicate the same or similar components or parts. It should be understood by those skilled in the art that these drawings are not necessarily drawn to scale. In the accompanying drawings:

[0040] Figure 1 is a schematic diagram of a biological detection device according to one embodiment of the present invention;

[0041] Figure 2 is a schematic exploded view of the structure of a biological detection device according to one embodiment of the present invention;

[0042] Figure 3 is a schematic structural cross-sectional view of a biological detection chip according to one embodiment of the present invention;

[0043] Figure 4 is a schematic flow chart of a control method of a biological detection device according to a first embodiment of the present invention;

[0044] Figure 5 is a schematic flow chart of a control method for a biological detection device according to a second embodiment of the present invention;

[0045] Figure 6 is a schematic cross-sectional view of a biological detection chip installed in a biological detection device according to one embodiment of the present invention;

[0046] Figure 7 is a schematic flow chart of controlling a driving mechanism to perform a fluid pushing action according to one embodiment of the present invention;

[0047] Figure 8is a schematic flow chart of a control method of a biological detection device according to a fourth embodiment of the present application;

[0048] Figure 9 is a schematic front perspective view of a biological detection device according to an embodiment of the present application;

[0049] Figure 10 is another schematic structural sectional view of a biological detection chip according to an embodiment of the present application;

[0050] Figure 11 is a schematic structural view of a refrigerator according to an embodiment of the present application;

[0051] Figure 12 is a schematic structural exploded view of a door body according to an embodiment of the present application. DETAILED DESCRIPTION

[0052] The present application first provides a control method of a biological detection device, Figure 1 is a schematic view of a biological detection device according to an embodiment of the present application, Figure 2 is a schematic structural exploded view of a biological detection device according to an embodiment of the present application. The biological detection device 1 of the present application has a driving mechanism 30 and a chip mounting portion 11 for mounting a biological detection chip. Figure 3 is a schematic structural sectional view of a biological detection chip according to an embodiment of the present application. The biological detection chip 2 has a plurality of mutually independent detection channels 20. Each detection channel 20 is capable of qualitatively or quantitatively detecting a preset detection parameter of a sample. The preset detection parameter may, for example, be a pesticide residue parameter for indicating whether the pesticide residue amount exceeds a standard and / or a specific value of the pesticide residue amount, a nutrient parameter for indicating whether a nutrient element meets a standard and / or a specific content of the nutrient element, a specific substance parameter for indicating whether a specific harmful substance (e.g. a specific virus) exceeds a standard and / or a specific content, and the like.

[0053] Figure 4 is a schematic flow chart of a control method of a biological detection device according to a first embodiment of the present application. The control method of the present application comprises:

[0054] In step S10, a first trigger signal indicating that the biological detection chip 2 has been mounted to the chip mounting portion 11 is received. Specifically, a trigger switch can be provided in the chip mounting portion 11, and when the biological detection chip 2 is mounted to the chip mounting portion 11 and touches the trigger switch, the first trigger signal is generated. The trigger switch may, for example, be a Hall switch.

[0055] Step S30, start the driving mechanism 30, and drive the fluid flow in each detection channel 20 simultaneously through the driving mechanism 30. Specifically, the driving mechanism 30 can be in fluid communication with each detection channel 20, and the flow time, flow path, flow rate, etc. of the sample liquid in each detection channel 20 can be controlled by controlling the driving mechanism 30, so as to facilitate the smooth and efficient progress of the detection process.

[0056] The biological detection device 1 of the present application can install a biological detection chip 2 having a plurality of independent detection channels 20, and when the biological detection device 1 receives a first trigger signal indicating that the biological detection chip 2 has been installed to the chip mounting portion 11, the driving mechanism 30 is automatically started, and the fluid flow in each detection channel 20 is driven simultaneously through the driving mechanism 30, thereby allowing the plurality of detection channels 20 to perform detection operations simultaneously, meeting the needs of users who need to detect a plurality of different samples or different parameters of the same sample, and the plurality of detection channels 20 of the present application perform detection processes simultaneously, which takes the same time as detecting one detection parameter of one sample, shortens the overall time required for detection, facilitates users to compare and analyze the detection results of the plurality of detection channels 20, and improves the user experience.

[0057] In some embodiments, each detection channel 20 includes a sampling chamber 21 for containing an extraction liquid. The biological detection device 1 includes a sample adding structure 70 for pushing a solid sample resting outside each sampling chamber 21 into the sampling chamber 21 when the biological detection chip 2 is installed to the chip mounting portion 11, so that the solid sample is soaked in the extraction liquid in the sampling chamber 21. The detected substance on the solid sample dissolves into the extraction liquid to produce a sample liquid. In this way, the sample adding operation can be automatically completed during the installation process of the biological detection chip 2, and the user only needs to rest the solid sample outside the sampling chamber 21 and directly install the biological detection chip 2, without the need for other operations or the need to set other auxiliary sample adding driving mechanisms on the biological detection device 1, thereby simplifying the structure of the biological detection device 1, reducing its cost, improving the user experience, and making it more suitable for home use.

[0058] Figure 5 is a schematic flow chart of the control method of the biological detection device according to the second embodiment of the present application. In some embodiments, after receiving the first trigger signal and before starting the driving mechanism 30, the control method of the present application further includes:

[0059] Step S20: Wait for a first preset time period to allow the sample to be immersed in the extraction solution for a sufficient period of time to ensure that the substance to be detected on the sample is fully dissolved in the extraction solution, thereby obtaining a sample solution of appropriate concentration. Specifically, the first preset time period can be a length of time that has been verified through multiple experiments to allow the substance to be detected on the sample to fully dissolve in the extraction solution. For example, the first preset time period can be any value between 1 and 20 minutes.

[0060] Figure 6 : is a schematic cross-sectional view of a biological detection chip according to an embodiment of the present invention after being installed in a biological detection device. In some embodiments, each detection channel 20 further includes a reaction chamber 22 for accommodating reaction reagents and a detection chamber 23 for accommodating detection reagents, and the sampling chamber 21, reaction chamber 22 and detection chamber 23 of the same detection channel 20 are connected in sequence with the cooperation of the chip mounting portion 11. That is to say, before the biological detection chip 2 is installed, the sampling chamber 21, reaction chamber 22 and detection chamber 23 of the same detection channel 20 can be isolated from each other to avoid mutual influence between the sampling chamber 21, reaction chamber 22 and detection chamber 23, and allow reagents of different types and different states (liquid, solid, gaseous) to be pre-stored in the sampling chamber 21, reaction chamber 22 and detection chamber 23. The driving mechanism 30 is connected to the sampling chamber 21 of each detection channel 20.

[0061] In some embodiments, the step S30 of simultaneously driving the fluid flow in each detection channel 20 by the driving mechanism 30 specifically includes:

[0062] The driving mechanism 30 is controlled to perform a liquid-pushing action, thereby causing the sample liquid in the sampling chamber 21 of each detection channel 20 to flow sequentially toward the reaction chamber 22 and detection chamber 23 of that detection channel 20. In other words, the liquid-pushing action of the driving mechanism 30 can push out at least a portion of the sample liquid generated in the sampling chamber 21, causing the pushed-out sample liquid to flow first toward the reaction chamber 22 and then toward the detection chamber 23. Thus, the driving mechanism 30 controls the flow of the sample liquid in each detection channel 20.

[0063] Figure 7 FIG. 1 is a schematic flow chart of controlling a drive mechanism to perform a fluid pushing action according to an embodiment of the present invention. In some embodiments, the steps of controlling the drive mechanism 30 to perform the fluid pushing action specifically include:

[0064] In step S301, the driving mechanism 30 causes the sample liquid in the sampling chamber 21 of each detection channel 20 to flow to the reaction chamber 22 of the detection channel 20, so that the sample liquid reacts with the reaction reagent in the reaction chamber 22. The reaction reagent in the reaction chamber 22 can be pre-installed in the reaction chamber 22 and can be colloidal gold attached to the inner wall of the reaction chamber 22.

[0065] In step S303 , the driving mechanism 30 is stopped to leave enough time for the sample liquid and the reaction reagent to react, thereby facilitating a sufficient reaction between the sample liquid and the reaction reagent.

[0066] Step S305 determines whether the duration of the drive mechanism 30 being stopped has reached a second preset duration. If so, the process proceeds to step S307. The second preset duration can be a length of time that has been verified through multiple tests to allow the sample solution and the reaction reagent to fully react. For example, the second preset duration can be any value between 0 and 10 minutes.

[0067] In step S307, the drive mechanism 30 is activated again to cause the sample liquid in the reaction chamber 22 of each detection channel 20 to flow to the detection chamber 23 of that detection channel. This allows the sample liquid flowing out of the reaction chamber 22, after reacting with the reaction reagent, to react again with the detection reagent in the detection chamber 23, thereby obtaining a test result. The detection reagent can be pre-placed in the detection chamber 23. A test strip 60 can be provided in the detection chamber 23, with the detection reagent integrated on the test strip 60. At least one side of the detection chamber 23 is open or transparent to facilitate user observation of the test result on the test strip 60.

[0068] Furthermore, before stopping the driving mechanism 30, the step of controlling the driving mechanism 30 to perform the liquid pushing action may further include:

[0069] Step S302, determining whether the sample liquid flowing into the reaction chamber 22 reaches a preset sample volume;

[0070] If yes, go to step S303 to stop the driving mechanism 30.

[0071] That is to say, the present application also accurately detects and controls the amount of sample liquid entering the reaction chamber 22 so that it matches the amount of reaction reagents and detection reagents in the biological detection chip 2, avoiding the impact of excessive or insufficient amount of sample liquid on the detection results, and further improving the accuracy of the detection results.

[0072] Specifically, the driving mechanism 30 can be a syringe pump, which promotes the flow of fluid in the detection channel 20 by pressing air into the detection channel 20. Specifically, the driving mechanism 30 may include a driving motor 31, a screw 32, a slider 33, a syringe 34 and a piston 35. The driving motor 31 is used to output driving force. The screw 32 is connected to the driving motor 31 so as to rotate under the drive of the driving motor 31. The slider 33 is passed through the screw 32 and is threadedly connected to the screw 32 so as to translate along the screw 32 as the screw 32 rotates. The first end of the syringe 34 is connected to the connecting channel 12. The piston 35 is arranged inside the syringe 34 and is fixedly connected to the slider 33 so as to move inside the syringe 34 driven by the slider 33, thereby promoting the flow of fluid in the sampling chamber 21 when it moves toward the first end of the syringe 34.

[0073] Further, the step of judging whether the sample liquid flowing into the reaction chamber 22 reaches the preset sample amount specifically comprises:

[0074] detecting the position of the piston 35 of the driving mechanism 30;

[0075] When the piston 35 moves to the preset position, it is determined that the sample liquid in the reaction chamber 22 reaches the preset sample amount.

[0076] Since the piston 35 is inside the syringe 34, directly detecting the position of the piston 35 needs to design a complex structure. However, the piston 35 is fixedly connected with the slider 33 outside, so the position of the piston 35 can be obtained by detecting the position of the slider 33. The position of the slider 33 can be detected by the position sensor 92. The operation of the driving motor 31 can be controlled through the position of the slider 33, so as to control the displacement amount of the piston 35 in the syringe 34 to control the flow path of the fluid in the detection channel, which is convenient for monitoring the position of the piston 35 and the displacement amount of the movement thereof, and further realizes the accurate control of the fluid flow path. The position sensor 92 can be arranged on the circuit board 93 and electrically connected with the circuit board 93.

[0077] In some embodiments, when the biological detection chip 2 is vertically placed in the chip mounting portion 11 so that each detection channel 20 in the chip 2 extends vertically, after receiving the first trigger signal, and before the step S20 of waiting for the first preset time length, the control method of the present application further comprises:

[0078] starting the driving mechanism 30 to control the driving mechanism 30 to perform a liquid suction action to generate a certain negative pressure in each detection channel 20, so that the sample liquid in the sampling chamber 21 can overcome its own gravity under the action of the negative pressure and remain in the sampling chamber 21 without flowing downward. Thus, the sample liquid can be prevented from flowing uncontrollably to the reaction chamber 22 and / or the detection chamber 23, and even from leaking. The action force of the liquid suction action of the driving mechanism 30 on the fluid in the detection channel 20 is opposite to the action force of the liquid pushing action of the driving mechanism 30 on the fluid in the detection channel 20. The action force direction of the liquid pushing action of the driving mechanism 30 on the fluid in the detection channel 20 is from the sampling chamber 21 to the reaction chamber 22, i.e. the direction of pushing the sample liquid out of the sampling chamber 21 and into the reaction chamber 22. The action force direction of the liquid suction action of the driving mechanism 30 on the fluid in the detection channel 20 is from the reaction chamber 22 to the sampling chamber 21, i.e. the sample liquid in the sampling chamber 21 has a tendency to move away from the reaction chamber 22.

[0079] Figure 8is a schematic flow chart of a control method of a biological detection device according to the fourth embodiment of the present application. In some embodiments, after causing the sample liquid in the reaction chamber 22 of each detection channel 20 to flow to the detection chamber 23 of the detection channel 20, the control method of the present application further comprises:

[0080] At step S40, the prompting information for prompting the detection result is sent out after waiting for a third preset time length. The prompting information can include any one or more of sound, light, and electricity signals. The third preset time length can be a length of time verified by multiple tests to be able to make the sample liquid and the detection reagent fully react. For example, the third preset time length can be any length value between 0 and 15 minutes.

[0081] In some embodiments, the driving mechanism 30 can be a syringe pump. The control method of the present application further comprises:

[0082] When the second trigger signal for indicating that the biological detection chip 2 is removed from the chip mounting portion 11 is received, the piston 35 of the driving mechanism 30 is controlled to return to the initial position. Thus, it is ensured that the driving mechanism 30 can start from the initial position each time a new biological detection chip 2 is installed, avoiding larger error accumulation after multiple movements of the driving mechanism 30, and improving the accuracy of the sample liquid flow control.

[0083] The present application also provides a biological detection device 1, which operates according to the control method described in any of the above embodiments.

[0084] Specifically, the biological detection device 1 further comprises a bracket 10, and the circuit board 93 can be fixed on the bracket 10 through the clamping jaw 14. The chip mounting portion 11 is formed on the bracket 10, and a plurality of fluid interfaces 111 for one-to-one communication with the plurality of detection channels 20 in the biological detection chip 2 are formed on the chip mounting portion 11. The driving mechanism 30 is arranged on the bracket 10 and communicates with each fluid interface 111, so that after the biological detection chip 2 is installed on the chip mounting portion 11, the driving mechanism 30 communicates with the sampling chamber 21 of each detection channel 20 through the plurality of fluid interfaces 111, thereby controlling the fluid flow in each detection channel 20.

[0085] Figure 9is a schematic front perspective view of a biological detection device according to an embodiment of the present application. In some embodiments, a connecting channel 12 is formed in the bracket 10, one end of the connecting channel 12 is in communication with the driving mechanism 30, and the other end has a plurality of branch channels 121, which are in communication with a plurality of fluid interfaces 111 respectively and one by one, so as to drive the fluid in the plurality of detection channels of the biological detection chip installed in the chip mounting portion 11 simultaneously through the driving mechanism 30. The connecting channel 12 can further include an inclined channel 122 connected between the driving mechanism 30 and each branch channel 121. When the driving mechanism 30 is located at the upper portion of the bracket 10 and the chip mounting portion 111 is formed at the lower portion of the bracket 10, the inclined channel 122 extends from back to front obliquely from top to bottom. The present application designs the connecting channel 12 for communication between the driving mechanism 30 and each fluid interface 111 inside the bracket 10, which avoids the problems of great difficulty in arrangement, large volume, and easy interference with other structures caused by external connection of the connecting pipeline between the driving mechanism 30 and each fluid interface 111, simplifies the structure of the biological detection device 1, and makes it more suitable for integration in a refrigerator or other household appliances.

[0086] In some embodiments, the biological detection device 1 further includes a front cover 91 covering the front side of the bracket 10, so as to cover at least part of the structure of the bracket 10, and avoid the bracket 10 and the circuit board 93, the driving mechanism 30 and the like installed on the bracket 10 from being exposed to the front side of the biological detection device 1 and affecting the appearance thereof.

[0087] Further, the front cover 91 is provided with a gap 911, and the chip mounting portion 11 is exposed to the front side of the front cover 91 through the gap 911, so as to facilitate the biological detection chip to be installed to the chip mounting portion 11 through the gap 911.

[0088] Figure 10 is another schematic structural cross-sectional view of a biological detection chip according to an embodiment of the present application. In some embodiments, at least part of the peripheral walls of the sampling chamber 21 and the reaction chamber 22 of each detection channel 20 are penetrable walls, so as to form at least one penetration orifice under the action of the piercing structure on the chip mounting portion 11. The chip mounting portion 11 is provided with a first piercing structure 51 having a first through channel 511 formed inside, which is used to pierce the penetrable wall 221 of the reaction chamber 22 and the penetrable wall 211 of the sampling chamber 21 of the same detection channel 20 after the biological detection chip 2 is installed to the chip mounting portion 11, and allow the reaction chamber 22 and the sampling chamber 21 of the same detection channel 20 to form fluid communication through the first through channel 511.

[0089] Further, each detection chamber 23 of each detection channel 20 is provided with a liquid injection port 231 in communication with the interior thereof. The chip mounting portion 11 is further provided with a second piercing structure 52 having a second through channel 521 formed therein, which is used to pierce the penetrable wall 222 of the corresponding reaction chamber 22 after the biological detection chip 2 is mounted to the chip mounting portion 11, and allow the reaction chamber 22 to communicate with the liquid injection port 231 of the corresponding detection chamber 23 through the second through channel 521.

[0090] That is, the penetrable walls of the sampling chamber 21 and the reaction chamber 22 can be pierced by the first piercing structure 51 to form fluid communication therebetween, and the penetrable wall of the reaction chamber 22 can be pierced by the second piercing structure 52 to form fluid communication between the reaction chamber 22 and the detection chamber 23. In this way, the complex connecting pipeline is omitted, the structure is simplified, and the sampling chamber 21, the reaction chamber 22 and the detection chamber 23 of the biological detection chip 2 can be arranged in a spaced manner, which is conducive to the long-term storage of the biological detection chip 2 and allows the sampling chamber, the reaction chamber or the detection chamber to pre-store liquid reagents.

[0091] The outer side of each sampling chamber 21 is provided with a sampling port 24 for placing a solid sample, and the sampling port 24 corresponds to the position of the sample adding structure 70 of the biological detection device 1 one-to-one, so as to allow each sample adding structure 70 to push the solid sample placed in the corresponding sampling port 24 into the corresponding sampling chamber 21 when the biological detection chip 2 is mounted to the biological detection device 1. The sampling port 24 and the sampling chamber 21 are separated by another penetrable wall 212 of the sampling chamber 21, and the sample adding structure 70 can pierce the penetrable wall 212 to push the sample into the sampling chamber 21.

[0092] Specifically, the sampling port 24 can be recessed towards the direction of the sampling chamber 21, so as to facilitate the retention of the solid sample therein and avoid the falling of the solid sample. The plurality of sampling ports 24 can be spaced from each other, thereby forming a plurality of independent recesses. The plurality of sampling ports 24 can also not be spaced, thereby forming a complete recess.

[0093] The chip mounting portion 11 is further provided with a connecting column corresponding to and adjacent to the sample adding structure 70, and a branch channel 121 is formed in the interior of the connecting column. After the biological detection chip 2 is mounted to the chip mounting portion 11, the connecting column pierces the penetrable wall 213 on the top of the corresponding sampling pool 21, so that the branch channel 121 in the connecting column communicates with the corresponding sampling pool 21.

[0094] The application further provides a refrigerator, Figure 11is a schematic structural diagram of a refrigerator according to an embodiment of the present application. The refrigerator 100 of the present application comprises the biological detection device 1 operating according to the control method described in any of the above embodiments. The refrigerator 100 can further comprise the biological detection chip 2 mounted on the biological detection device 1. The refrigerator 100 is used frequently in daily life and is mainly used to store foodstuffs. When the biological detection device 1 is integrated on the refrigerator 100, the user can easily perform the detection operation of the foodstuff sample by using the biological detection device 1.

[0095] Further, the refrigerator 100 further comprises a cabinet 200 and a door body 300. The cabinet 200 defines a storage space therein, and the door body 300 is connected to the cabinet 200 and is used to open and / or close the storage space. The biological detection device 1 is preferably arranged on the door body 300, which is not only convenient to operate, but also does not occupy the original storage space in the cabinet 200 and does not affect the storage capacity of the refrigerator 100 itself.

[0096] Figure 12 is a schematic structural exploded view of a door body according to an embodiment of the present application. In some embodiments, the front side of the door body 300 is provided with a hollow window 301, and the chip mounting portion 11 is exposed to the front side of the door body 300 through the hollow window 301, so that the user can install the biological detection chip 2 to implement the detection function without opening the door body 300, thereby ensuring the heat preservation performance of the refrigerator 100 and saving energy consumption.

[0097] Specifically, the door body 300 can comprise a panel 302 for forming the front part thereof, a door lining 303 for forming the rear part thereof, and a foamed heat preservation layer (not shown in the figure) arranged between the panel 302 and the door lining 303, and the hollow window 301 is formed in the panel 302. A pre-embedded box 304 is pre-embedded between the panel 302 and the door lining 303 before the foamed heat preservation layer is formed, and the biological detection device 1 is arranged in the pre-embedded box 304. That is, the pre-embedded box 304 is pre-arranged between the panel 302 and the door lining 303 before the door body 300 is foamed, and is used to reserve a space for mounting the biological detection device 1 between the panel 302 and the door lining 303.

[0098] Further, the pre-embedded box 304 is attached to the rear surface of the panel 302, and the front side of the pre-embedded box 304 is open and faces the hollow window 301, so as to allow the biological detection device 1 to be mounted into the pre-embedded box 304 from front to back through the hollow window 301, thereby improving the convenience of mounting the biological detection device 1.

[0099] The refrigerator 100 of the present application is a refrigerator in a broad sense, which not only includes the refrigerator in a narrow sense as usually said, but also includes a storage device having a cold storage, a freezing or other storage function, such as a refrigerator, a refrigerator cabinet, etc.

[0100] At this point, those skilled in the art will appreciate that although specific exemplary embodiments of the application have been described herein, the present application also encompasses many other variations or modifications in form, function, terminology and / or detail which have not been expressly described herein but which are within the scope of the present application. Accordingly, the scope of the present application should be gauged by the claims and not by the details of the description.

Claims

1. A control method for a biological detection device, wherein the biological detection device comprises a drive mechanism and a chip mounting portion for mounting a biological detection chip, wherein the biological detection chip has multiple independent detection channels, the control method comprising: receiving a first trigger signal indicating that the biological detection chip has been installed on the chip installation portion; Starting the driving mechanism to simultaneously drive the fluid in each of the detection channels to flow; in, Each of the detection channels includes a sampling chamber for containing an extracting liquid; the biological detection device includes a sample loading structure for pushing a solid sample placed outside each sampling chamber into the sampling chamber when the biological detection chip is mounted on the chip mounting portion, so that the solid sample is immersed in the extracting liquid in the sampling chamber; and After receiving the first trigger signal and before starting the driving mechanism, the control method further includes: waiting for a first preset time period; Each of the detection channels further comprises a reaction chamber for accommodating a reaction reagent and a detection chamber for accommodating a detection reagent, the sampling chamber, the reaction chamber and the detection chamber of the same detection channel are sequentially connected with the cooperation of the chip mounting portion, and the driving mechanism is connected with the sampling chamber of each detection channel; and The step of simultaneously driving the fluid flow in each of the detection channels by the driving mechanism comprises: Controlling the driving mechanism to perform a liquid pushing action to cause the sample liquid in the sampling chamber of each detection channel to flow to the reaction chamber and the detection chamber of the detection channel in sequence; A first through-channel and a first piercing structure are formed inside the chip mounting portion, for piercing the penetrable wall of the reaction chamber and the penetrable wall of the sampling chamber of the same detection channel after the biological detection chip is mounted on the chip mounting portion, and allowing fluid communication between the reaction chamber and the sampling chamber of the same detection channel through the first through-channel; A second through-channel and a second piercing structure are also formed inside the chip mounting portion, which are used to pierce the penetrable wall of the corresponding reaction chamber after the biological detection chip is installed in the chip mounting portion, and allow the reaction chamber to communicate with the corresponding detection chamber through the second through-channel.

2. The control method according to claim 1, wherein: The steps of controlling the driving mechanism to perform the liquid pushing action specifically include: Prompt the sample liquid in the sampling chamber of each detection channel to flow to the reaction chamber of the detection channel by the driving mechanism; stopping the driving mechanism; When the driving mechanism is stopped for a second preset time, the driving mechanism is started again to force the sample liquid in the reaction chamber of each detection channel to flow to the detection chamber of the detection channel.

3. The control method according to claim 2, wherein: Before stopping the driving mechanism, the step of controlling the driving mechanism to perform the fluid pushing action further includes: determining whether the sample liquid flowing into the reaction chamber reaches a preset sample volume; If so, the driving mechanism is stopped.

4. The control method according to claim 3, wherein: The driving mechanism is a syringe pump, The step of determining whether the sample liquid flowing into the reaction chamber reaches a preset sample volume includes: detecting the position of the piston of the driving mechanism; When the piston moves to the preset position, it is determined that the sample liquid in the reaction chamber has reached the preset sample volume.

5. The control method according to claim 2, wherein: After causing the sample liquid in the reaction chamber of each detection channel to flow to the detection chamber of the detection channel, the control method further includes: After waiting for a third preset time period, a prompt message is issued to indicate that the detection result has been displayed.

6. The control method according to claim 1, wherein: The driving mechanism is a syringe pump, The control method further includes: When a second trigger signal for instructing the biological detection chip to be removed from the chip mounting portion is received, the piston of the driving mechanism is controlled to return to an initial position.

7. A biological detection device, wherein the biological detection device operates according to the control method according to any one of claims 1 to 6.

8. A refrigerator comprising a biological detection device operated according to the control method according to any one of claims 1 to 6.

Images