Bio-detection chip, bio-detection device and refrigerator

Abstract

The present application relates to biological detection chip, biological detection device and refrigerator, the biological detection chip is used for qualitative and / or quantitative detection of preset detection parameters of sample, and the biological detection chip comprises a plurality of parallelly arranged and independent detection channels, each detection channel has a detection chamber for containing detection reagent. Therefore, the plurality of detection channels do not affect each other, each detection channel can independently detect one detection parameter of one sample, the plurality of detection channels can simultaneously detect a plurality of different samples or a plurality of different parameters of the same sample, save the detection required material, reduce the detection time, simplify the detection process, improve the detection efficiency, and improve the user's use experience.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of refrigeration and freezing, and in particular to a biological detection chip, a biological detection device and a refrigerator. BACKGROUND

[0002] With the improvement of people's living standards, it is often necessary to detect the pesticide residues, viruses, nutritional elements or other aspects of some food materials in daily life to qualitatively or quantitatively obtain the conditions of the food materials. For example, due to the problem of pesticide abuse, the fruits, vegetables and agricultural and sideline products purchased by us in daily life may have the problem of excessive pesticide residues, and if the problem of excessive pesticide residues of these foods cannot be found in time, it will cause great harm to the human body after being ingested. For another example, the current breastfeeding is the best feeding for infants only when the breast milk has normal nutritional value, however, in the case of illness, medication, surgery or other conditions of the lactating mother, the nutritional element content in the milk secreted by the lactating mother may be reduced or even viruses may be produced, thereby affecting the growth and health of the infant.

[0003] Among many detection methods, the method of using a biological detection chip for detection is relatively fast and small in size, and is suitable for household use. However, the existing biological detection chip only contains one detection flow path, and one biological detection chip can only detect one parameter of one sample at a time. If a user needs to detect multiple different samples or different parameters of the same sample, multiple biological detection chips need to be used for multiple detections, which is time-consuming and costly, and the operation is complex, and the user experience effect is poor. SUMMARY

[0004] One object of the first aspect of the present application is to overcome at least one defect of the prior art, and to provide a biological detection chip capable of simultaneously detecting multiple different samples or multiple different parameters of the same sample.

[0005] One further object of the first aspect of the present application is to improve the operation convenience of the user using the biological detection chip.

[0006] One object of the second aspect of the present application is to provide a biological detection device for installing the biological detection chip according to any one of the above aspects.

[0007] One object of the third aspect of the present application is to provide a refrigerator having the biological detection device according to any one of the above aspects.

[0008] According to the first aspect of the present application, the present application provides a biological detection chip for qualitatively and / or quantitatively detecting a preset detection parameter of a sample, wherein

[0009] The biological detection chip comprises a plurality of detection channels which are arranged in parallel and are independent of each other, and each of the detection channels has a detection chamber for containing a detection reagent.

[0010] Optionally, each of the detection channels further includes a sampling chamber for providing sample liquid to the detection chamber of the detection channel, and the sampling chambers of the detection channels are independent of each other.

[0011] Optionally, an extraction liquid is pre-placed in the sampling chamber to mix with the extraction liquid after the sample is placed in the sampling chamber to produce a sample liquid.

[0012] Optionally, each of the detection channels further includes a reaction chamber for accommodating reaction reagents, wherein the reaction chamber is located between the sampling chamber and the detection chamber to allow the sample liquid in the sampling chamber to flow through the reaction chamber and then into the detection chamber.

[0013] Optionally, the reaction reagent is pre-placed in the reaction chamber; and / or

[0014] The reaction reagent is colloidal gold attached to the inner wall of the reaction chamber.

[0015] Optionally, the detection reagent is pre-placed in the detection chamber; and / or

[0016] A test paper is provided in the detection chamber, the detection reagent is integrated on the test paper, and at least one side of the detection chamber is open or transparent.

[0017] Optionally, a plurality of the detection channels are arranged side by side along the width direction of the biological detection chip, and each of the detection channels extends along the length direction of the biological detection chip; and

[0018] The detection chambers of the plurality of detection channels are located on the same side of the biological detection chip in its length direction.

[0019] According to a second aspect of the present invention, the present invention further provides a biological detection device for installing the biological detection chip involved in any of the above solutions, and comprising:

[0020] The chip mounting portion is formed with a plurality of fluid interfaces corresponding to the plurality of detection channels of the biological detection chip, so that each of the fluid interfaces is connected to a corresponding detection channel after the biological detection chip is mounted on the chip mounting portion.

[0021] Optionally, the biological detection device further includes:

[0022] a driving mechanism having an output port;

[0023] A connecting channel is also formed inside the chip mounting portion, one end of the connecting channel is connected to the output port, and the other end has a plurality of branch channels, and the plurality of branch channels are respectively connected to the plurality of fluid interfaces one by one, so as to simultaneously drive the fluids in the plurality of detection channels of the biological detection chip installed in the chip mounting portion through the driving mechanism.

[0024] According to a third aspect of the present invention, the present invention further provides a refrigerator comprising the biological detection device according to any one of the above solutions.

[0025] The biological detection chip of the present invention has multiple parallel and independent detection channels, each detection channel has a detection chamber for accommodating detection reagents. Therefore, the multiple detection channels do not affect each other. Each detection channel can independently detect one of the detection parameters of a sample. Multiple detection channels can simultaneously detect multiple different samples or multiple different parameters of the same sample, saving the materials required for detection, reducing detection time, simplifying the detection process, improving detection efficiency, and enhancing the user experience.

[0026] Furthermore, the sampling chamber is pre-installed with extraction liquid. When in use, the sample only needs to be placed in the sampling chamber. The substance to be detected on the sample dissolves in the extraction liquid to form a sample liquid of appropriate concentration, which saves the user the tedious operation of manually preparing the sample liquid and improves the operational convenience of the user using the biological detection chip for detection.

[0027] Based on the following detailed description of specific embodiments of the present invention in conjunction with the accompanying drawings, those skilled in the art will become more aware of the above and other objects, advantages and features of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Hereinafter, some specific embodiments of the present invention will be described in detail in an exemplary and non-limiting manner with reference to the accompanying drawings. The same reference numerals in the accompanying drawings indicate the same or similar components or parts. It should be understood by those skilled in the art that these drawings are not necessarily drawn to scale. In the accompanying drawings:

[0029] Figure 1 is a schematic structural diagram of a biological detection chip according to one embodiment of the present invention;

[0030] Figure 2 and Figure 3 Schematic cross-sectional views of a biological detection chip according to an embodiment of the present invention taken along different cross-sectional planes;

[0031] Figure 4 is a schematic structural diagram of a biological detection device according to one embodiment of the present invention;

[0032] Figure 5is a schematic exploded view of the structure of a biological detection device according to one embodiment of the present invention;

[0033] Figure 6 is a schematic cross-sectional view of a biological detection device according to one embodiment of the present invention;

[0034] Figure 7 is a schematic front perspective view of a biological detection device according to one embodiment of the present invention;

[0035] Figure 8 is a schematic cross-sectional view of a biological detection chip installed in a biological detection device according to one embodiment of the present invention;

[0036] Figure 9 yes Figure 8 A schematic enlarged view of the middle portion A;

[0037] Figure 10 is a schematic flow chart of a control method of a biological detection device according to one embodiment of the present invention;

[0038] Figure 11 is a schematic structural diagram of a refrigerator according to one embodiment of the present invention;

[0039] Figure 12 1 is a schematic structural exploded view of a door body according to one embodiment of the present invention. DETAILED DESCRIPTION

[0040] The present invention first provides a bioassay chip for qualitatively and / or quantitatively detecting preset detection parameters of a sample. These preset detection parameters may include, for example, a pesticide residue parameter indicating whether pesticide residue levels exceed standards and / or the specific value of the pesticide residue level, a nutritional parameter indicating whether nutrient elements meet standards and / or the specific content of the nutrient elements, or a specific substance parameter indicating whether a specific harmful substance (e.g., a specific virus) exceeds standards and / or the specific content of the specific substance.

[0041] Figure 1 is a schematic structural diagram of a biological detection chip according to one embodiment of the present invention, Figure 2 and Figure 3 These are schematic cross-sectional views of a biological detection chip according to an embodiment of the present invention taken along different cross-sectional planes. Figures 1 to 3The biological detection chip 2 of the present invention includes a plurality of detection channels 20 that are arranged in parallel and independent of each other, and each detection channel 20 has a detection chamber 23 for accommodating detection reagents. It should be noted that the parallel arrangement mentioned here means that the flow channels in each detection channel 20 are isolated and independent from each other, and the fluid in each detection channel will not flow through other detection channels. In other words, the multiple detection channels 20 do not affect each other, and each detection channel 20 can independently detect one of the detection parameters of a sample, and the multiple detection channels 20 can simultaneously detect multiple different samples or multiple different parameters of the same sample. Compared with the traditional biological detection chip with only one detection channel, the biological detection chip 2 of the present application saves the materials required for detection, reduces the number of times users install and replace chips, thereby reducing detection time, simplifying the detection process, improving detection efficiency, and enhancing the user experience.

[0042] In some embodiments, multiple detection channels 20 are arranged side by side along the width direction of the biological detection chip 2, and each detection channel 20 extends along the length direction of the biological detection chip 2, so that the layout on the biological detection chip 2 is more compact, thereby reducing the volume of the biological detection chip 2 and making it more suitable for integration into household appliances.

[0043] Furthermore, the detection chambers 23 of the multiple detection channels 20 are located on the same side of the biological detection chip 2 in its length direction, so that the user can observe the detection results of the multiple detection channels 20 at the same time, which is in line with the user's usage habits.

[0044] Specifically, the biological detection chip 2 further includes a body 40, and each detection channel 20 is formed on the body 40. Figure 1 In the illustrated embodiment, the body 40 is substantially in the shape of a rectangular parallelepiped, and the plurality of detection chambers 23 may be adjacent to the bottom of the body 40 and arranged side by side in a transverse direction.

[0045] In some embodiments, each detection channel 20 further includes a sampling chamber 21 for providing a sample liquid to the detection chamber 23 of the detection channel, and the sampling chambers 21 of each detection channel 20 are independent of each other. In other words, each detection channel 20 is sampled independently, so that each detection channel 20 can have different sample liquids, for example, the sample liquids of each detection channel 20 can be different in type, concentration or other aspects. Specifically, in Figure 1 In the illustrated embodiment, the plurality of sampling chambers 21 may be adjacent to the top of the body 40 and arranged side by side in a transverse direction.

[0046] Furthermore, an extracting liquid is pre-installed in the sampling chamber 21 to mix with the extracting liquid in the sample after the sample is placed in the sampling chamber 21 to produce a sample liquid. When in use, the user only needs to place the sample in the sampling chamber, and the substance to be detected on the sample dissolves in the extracting liquid to form a sample liquid of appropriate concentration, eliminating the tedious operation of the user manually preparing the sample liquid, thereby improving the convenience of the user in using the biological detection chip 2 for detection. The type and amount of the extracting liquid in the sampling chamber 21 of different detection channels 20 can be the same or different as needed. In some alternative embodiments, the extracting liquid can also be added to the sampling chamber 21 of the biological detection chip 2 when it is in use.

[0047] In some embodiments, each detection channel 20 further includes a reaction chamber 22 for accommodating a reaction reagent. The reaction chamber 22 is located between the sampling chamber 21 and the detection chamber 23, allowing the sample liquid in the sampling chamber 21 to flow through the reaction chamber 22 and then into the detection chamber 23. That is, in the direction of fluid flow in the detection channel 20, the reaction chamber 22 is downstream of the sampling chamber 21 and upstream of the detection chamber 23. For a specific sample liquid or for some specific detection parameters of the sample liquid, it is necessary to first react the sample liquid with the reaction reagent and then with the detection reagent. By arranging the reaction reagent and the detection reagent in the reaction chamber 22 and the detection chamber 23, respectively, which are located at different positions, it is possible to avoid reactions or mutual influences between the reaction reagent and the detection reagent, thereby improving the accuracy of the detection results.

[0048] In some embodiments, the reaction reagents are pre-installed in the reaction chamber 22 to avoid the trouble of manual addition of the reaction reagents by the user or to avoid the complicated structure caused by the automatic addition of the reaction reagents by the driving mechanism.

[0049] In some embodiments, the reaction reagent can be colloidal gold attached to the inner wall of the reaction chamber 22. The colloidal gold support arranged in this way is stable and not easy to move, so it is not easy to affect the sampling chamber 21 or the detection chamber 23, nor is it easily affected by the reagents in the sampling chamber 21 or the detection chamber 23.

[0050] In some embodiments, the detection reagent is pre-placed in the detection chamber 23 to avoid the troublesome operation caused by the user manually adding the detection reagent or to avoid the complicated structure caused by using a driving mechanism to automatically add the detection reagent.

[0051] In some embodiments, a test paper 60 is provided in the detection chamber 23 , and the detection reagent is integrated on the test paper 60 . At least one side of the detection chamber 23 is open or transparent to facilitate the user to observe the test results on the test paper 60 .

[0052] Of course, in some alternative embodiments, reaction reagents and detection reagents may be added to the reaction chamber 22 and detection chamber 23 respectively when the biological detection chip 2 is in use.

[0053] In some embodiments, the sampling chamber 21, reaction chamber 22, and detection chamber 23 of each detection channel 20 can be sequentially connected via microfluidics. In the absence of an external driving force, the fluids within the sampling chamber 21, reaction chamber 22, and detection chamber 23 can be maintained at a set position under the action of the microfluidics and will not flow to other positions. For example, the extract in the sampling chamber 21 will not flow to the reaction chamber 22 or detection chamber 23 under the action of the microfluidics to affect the reagents in the reaction chamber 22 or detection chamber 23.

[0054] In some preferred embodiments, the sampling chamber 21, reaction chamber 22, and detection chamber 23 of each detection channel 20 can also be isolated from each other. Only after the biological detection chip 2 is installed in its installation position, the sampling chamber 21, reaction chamber 22, and detection chamber 23 of each detection channel 20 are connected in sequence under the structural coordination of its installation position. Therefore, even if the sampling chamber 21, reaction chamber 22, and detection chamber 23 are pre-installed with corresponding types of reagents, regardless of whether the reagents are gaseous, liquid, or solid, the mutual influence between the sampling chamber 21, reaction chamber 22, and detection chamber 23 can be effectively avoided, so that the biological detection chip 2 can be preserved for a long time without becoming invalid.

[0055] The present invention further provides a biological detection device 1 for installing the biological detection chip 2 involved in any of the above embodiments. Figure 4 is a schematic structural diagram of a biological detection device according to an embodiment of the present invention, Figure 5 is a schematic structural exploded view of a biological detection device according to one embodiment of the present invention, Figure 6 is a schematic cross-sectional view of a biological detection device according to one embodiment of the present invention. Figure 7 FIG. 1 is a schematic front perspective view of a biological detection device according to one embodiment of the present invention.

[0056] The biological detection device 1 includes a chip mounting portion 11, which is formed with a plurality of fluid interfaces 111 corresponding to the plurality of detection channels 20 of the biological detection chip 2. When the biological detection chip 2 is mounted on the chip mounting portion 11, each fluid interface 111 is connected to a corresponding detection channel 20. This facilitates controlling the flow of fluid in each detection channel 20 and adding reagents to each detection channel 20 through the fluid interfaces 111. Thus, the biological detection device 1 can coordinate the multiple detection channels 20 of the biological detection chip 1 to simultaneously detect multiple different samples or multiple different parameters of the same sample.

[0057] In some embodiments, the biological detection device 1 further includes a drive mechanism 30 having an output port 341. A connecting channel 12 is also formed within the chip mounting portion 11. One end of the connecting channel 12 communicates with the output port 341, and the other end has multiple branch channels 121. Each of the multiple branch channels 121 communicates with the multiple fluid interfaces 111 in a one-to-one correspondence, thereby simultaneously driving the fluid within the multiple detection channels 20 of the biological detection chip 2 mounted in the chip mounting portion 11 via the drive mechanism 30. Each branch channel 121 can be connected to the output port 341 via an inclined channel 122 formed within the bracket 10.

[0058] In the present application, the connecting channel 12 for connecting the driving mechanism 30 and each fluid interface 111 is designed inside the chip mounting portion 11, thereby avoiding the problem that the external connecting pipes between the driving mechanism 30 and each fluid interface 111 are difficult to arrange, bulky, and easily interfere with other structures. This simplifies the structure of the biological detection device 1, making it more suitable for integration into a refrigerator or other household appliances.

[0059] Specifically, the chip mounting portion 11 may be formed on the bracket 10 of the biological detection device 1 , and the driving mechanism 30 is supported on the bracket 10 .

[0060] In some embodiments, the drive mechanism 30 is a micro-syringe pump that pressurizes air into the detection channel to promote fluid flow. When the drive mechanism 30 injects air into the detection channel, the pressure in the detection channel increases, and the fluid in the detection channel flows due to the pressure difference between the inside and outside of the detection channel.

[0061] Specifically, the driving mechanism 30 may include a driving motor 31, a screw rod 32, a slider 33, a syringe 34 and a piston 35. The driving motor 31 is used to output a driving force. The screw rod 32 is connected to the driving motor 31 so as to rotate under the drive of the driving motor 31. The slider 33 is passed through the screw rod 32 and is threadedly connected to the screw rod 32 so as to translate along the screw rod 32 as the screw rod 32 rotates. The first end of the syringe 34 is connected to the connecting channel 12. The piston 35 is arranged inside the syringe 34 and is fixedly connected to the slider 33 so as to move inside the syringe 34 under the drive of the slider 33, thereby promoting the flow of fluid in the detection channel when it moves toward the first end of the syringe 34.

[0062] Furthermore, the end of the drive motor 31 facing away from the screw rod 32 and the circumferential side of the drive motor 31 are spaced apart from the bracket 10. That is to say, except for the end portion fixedly connected to the bracket 10, the other positions of the drive motor 31 are not in contact with the bracket 10. Thus, sufficient space is provided for the heat dissipation of the drive motor 31, which is conducive to the timely dissipation of the heat generated by it. In addition, the transmission of the vibration generated by the drive motor 31 during operation to other components on the bracket 10 (such as the biological detection chip installed in the chip mounting portion) is reduced to a certain extent, avoiding affecting other components.

[0063] Because sample preparation and the reaction between the sample and the reagents require time, and the detection channel of the bioassay chip remains open after installation, the flow position and duration of the sample within the detection channel must be precisely controlled to ensure accurate test results. In other words, the movement amount and duration of the piston 35 are crucial during the operation of the drive mechanism 30.

[0064] To this end, in some embodiments, the biological detection device 1 further includes a position sensor 92, which is used to detect the position of the slider 33, so as to control the operation of the drive motor 31 through the position of the slider 33, thereby controlling the path of fluid flow in the detection channel by controlling the displacement of the piston 35 in the syringe 34, thereby facilitating monitoring the position of the piston 35 and the displacement of its movement, thereby achieving precise control of the fluid flow path.

[0065] In some embodiments, the biological detection device 1 further includes a circuit board 93, which is fixed to the bracket 10. The position sensor 92 can be disposed on the circuit board 93 and electrically connected to the circuit board 93. Specifically, the circuit board 93 can be fixed to the upper portion of the bracket 10, in front of the drive mechanism 30. A plurality of claws 14 can extend forward from the upper portion of the bracket 10 to engage the circuit board 93 therewith.

[0066] In some embodiments, the biological detection device 1 also includes a front cover 91, which is arranged on the front side of the bracket 10, thereby covering at least part of the structure of the bracket 10, preventing the bracket 10, and the circuit board 93 and the driving mechanism 30 installed on the bracket 10 from being exposed on the front side of the biological detection device 1 and affecting its appearance.

[0067] Furthermore, a notch 911 is formed on the front cover 91 , and the chip mounting portion 11 is exposed to the front side of the front cover 91 through the notch 911 , so that the biological detection chip can be mounted on the chip mounting portion 11 through the notch 911 .

[0068] Figure 8 is a schematic cross-sectional view of a biological detection chip installed in a biological detection device according to one embodiment of the present invention. Figure 9yes Figure 8 Schematic enlarged view of portion A in the middle. In some embodiments, the sampling chamber 21, reaction chamber 22, and detection chamber 23 of each detection channel 20 are isolated from each other. Only after the bioassay chip 2 is mounted on the chip mounting portion 11 do the sampling chamber 21, reaction chamber 22, and detection chamber 23 of each detection channel 20 connect sequentially, thanks to the structural coordination of the chip mounting portion 11.

[0069] Specifically, at least a portion of the peripheral walls of the sampling chamber 21 and reaction chamber 22 of each detection channel 20 are penetrable walls, so that at least one penetration opening is formed under the action of the piercing structure on the chip mounting portion 11. The chip mounting portion 11 is provided with a first piercing structure 51 having a first through-channel 511 formed therein. The first piercing structure 51 is configured to pierce the penetrable wall 221 of the reaction chamber 22 and the penetrable wall 211 of the sampling chamber 21 of the same detection channel 20 after the biological detection chip 2 is mounted on the chip mounting portion 11, thereby allowing fluid communication between the reaction chamber 22 and the sampling chamber 21 of the same detection channel 20 through the first through-channel 511.

[0070] Furthermore, each detection chamber 23 of the detection channel 20 has a liquid injection port 231 communicating therewith. The chip mounting portion 11 is also provided with a second piercing structure 52 having a second through-channel 521 formed therein. This structure is configured to pierce the permeable wall 222 of the corresponding reaction chamber 22 after the biological detection chip 2 is mounted on the chip mounting portion 11, thereby allowing the reaction chamber 22 to communicate with the liquid injection port 231 of the corresponding detection chamber 23 via the second through-channel 521.

[0071] That is, the first piercing structure 51 can be used to pierce the permeable walls of the sampling chamber 21 and the reaction chamber 22 to establish fluid communication therebetween, and the second piercing structure 52 can be used to pierce the permeable wall of the reaction chamber 22 to establish fluid communication between the reaction chamber 22 and the detection chamber 23. This eliminates the need for complex connecting pipes, simplifies the structure, and allows the sampling chamber 21, reaction chamber 22, and detection chamber 23 of the biological detection chip 2 to be spaced apart, facilitating the long-term storage of the biological detection chip 2 and allowing liquid reagents to be pre-stored in the sampling chamber, reaction chamber, or detection chamber.

[0072] In some embodiments, the chip mounting portion 11 is further provided with a plurality of sample loading structures 70 corresponding one to one with the sampling chamber 21. Each sample loading structure 70 is configured to push the solid sample placed on the outside of the corresponding sampling chamber 21 into the sampling chamber 21 when the biological detection chip 2 is mounted on the chip mounting portion 11, so that the solid sample is immersed in the extract in the sampling chamber 21. The substance to be detected on the solid sample dissolves in the extract to produce a sample liquid. Thus, the sample loading operation can be automatically completed during the installation process of the biological detection chip 2. The user only needs to place the solid sample outside the sampling chamber 21 and directly install the biological detection chip 2. No other operations are required, and there is no need to set other auxiliary sample loading drive mechanisms on the biological detection device 1. This simplifies the structure of the biological detection device 1, reduces its cost, improves the user experience, and makes it more suitable for home use.

[0073] Correspondingly, each sampling chamber 21 is provided with a sampling port 24 for holding a solid sample on its outer side. The sampling ports 24 correspond one-to-one with the positions of the sample loading structures 70 of the biological detection device 1. This allows each sample loading structure 70 to push the solid sample held in the corresponding sampling port 24 into the corresponding sampling chamber 21 when the biological detection chip 2 is installed in the biological detection device 1. The sampling port 24 is separated from the sampling chamber 21 by another permeable wall 212 of the sampling chamber 21. The sample loading structure 70 can penetrate the permeable wall 212 to push the sample into the sampling chamber 21.

[0074] Specifically, the sampling port 24 can be recessed toward the sampling chamber 21 to retain the solid sample therein and prevent it from falling. The multiple sampling ports 24 can be separated from each other to form multiple independent recesses. Alternatively, the multiple sampling ports 24 can be unseparated to form a single, complete recess.

[0075] The chip mounting portion 11 is also provided with connecting posts corresponding to and adjacent to the sample loading structures 70. Branch channels 121 are formed within the connecting posts. After the biological detection chip 2 is mounted on the chip mounting portion 11, the connecting posts penetrate the permeable wall 213 at the top of the corresponding sampling reservoir 21, thereby connecting the branch channels 121 within the connecting posts to the corresponding sampling reservoir 21.

[0076] The following describes in detail a method for controlling a biological detection chip mounted on a biological detection device using the biological detection device. Figure 10 FIG. 1 is a schematic flow chart of a control method for a biological detection device according to an embodiment of the present invention. The control method may include:

[0077] Step S10, receiving a first trigger signal indicating that the biological detection chip 2 has been installed in the chip installation portion 11;

[0078] Step S20, waiting for a first preset time period to allow the substance to be detected on the sample to fully dissolve into the extract in the sampling chamber 21, thereby forming a sample solution of appropriate concentration;

[0079] Step S31 , starting the driving mechanism 30 , causing the sample liquid in the sampling chamber 21 of each detection channel 20 to flow to the reaction chamber 22 of the detection channel through the driving mechanism 30 ;

[0080] Step S32, determining whether the sample liquid flowing into the reaction chamber 22 has reached a preset sample volume; if so, proceeding to step S33; in this step, this can be achieved by detecting the position of the piston. When the piston moves to the preset position, it indicates that the sample liquid flowing into the reaction chamber 22 has reached the preset sample volume;

[0081] Step S33, stopping the driving mechanism 30;

[0082] Step S34: When the driving mechanism 30 stops for a second predetermined time, the driving mechanism 30 is restarted to cause the sample liquid in the reaction chamber 22 of each detection channel 20 to flow to the detection chamber 23 of the detection channel 20;

[0083] Step S40: After waiting for a third preset time, a prompt message is issued to indicate that the detection result has been displayed.

[0084] Furthermore, the control method of the present invention further includes:

[0085] When the second trigger signal for instructing the biological detection chip 2 to be removed from the chip mounting portion 11 is received, the piston of the control driving mechanism 30 is restored to the initial position.

[0086] The present invention also provides a refrigerator. Figure 11 is a schematic structural diagram of a refrigerator according to one embodiment of the present invention. Refrigerator 100 of the present invention includes a biological detection device 1 according to any of the aforementioned embodiments, with biological detection device 1 integrated into refrigerator 100. Refrigerator 100 may also include a biological detection chip 2 mounted on biological detection device 1. Refrigerators 100 are frequently used in daily life and are primarily used to store food. When biological detection device 1 is integrated into refrigerator 100, users can easily utilize biological detection device 1 to perform food sample detection operations.

[0087] Furthermore, refrigerator 100 includes a housing 200 and a door 300. Housing 200 defines a storage space, and door 300 is connected to housing 200 and is used to open and / or close the storage space. Biodetection device 1 is preferably mounted on door 300, which not only makes operation more convenient but also does not occupy the existing storage space within housing 200, thereby not affecting the storage capacity of refrigerator 100.

[0088] Figure 12 This is a schematic exploded view of the door structure according to one embodiment of the present invention. In some embodiments, a hollow window 301 is provided on the front side of the door 300. The chip mounting portion 11 is exposed through the hollow window 301 to the front side of the door 300. This allows the user to install the biodetection chip 2 and perform detection functions without opening the door 300, thereby ensuring the heat preservation performance of the refrigerator 100 and saving energy.

[0089] Specifically, the door body 300 includes a panel 302 forming its front portion, a door lining 303 forming its rear portion, and a foam insulation layer (not shown) disposed between the panel 302 and the door lining 303. A hollow window 301 is provided in the panel 302. Before the foam insulation layer is formed, a pre-embedded box 304 is embedded between the panel 302 and the door lining 303. The biological detection device 1 is disposed within the pre-embedded box 304. In other words, the pre-embedded box 304 is pre-installed between the panel 302 and the door lining 303 before the door body 300 is foamed, reserving space between the panel 302 and the door lining 303 for mounting the biological detection device 1.

[0090] Furthermore, the embedded box 304 is attached to the rear surface of the panel 302, and the front side of the embedded box 304 is open and faces the hollow window 301, so as to allow the biological detection device 1 to be installed into the embedded box 304 from front to back through the hollow window 301, thereby improving the convenience of installation of the biological detection device 1.

[0091] Furthermore, the biological detection chip 2 is installed in the chip installation portion 11 in such a manner that each detection channel 20 is vertically extended, thereby facilitating installation of the biological detection chip 2 by the user and conforming to the user's operating habits.

[0092] The refrigerator 100 of the present application is a refrigerator in a broad sense, which not only includes the so-called refrigerator in a narrow sense, but also includes storage devices with refrigeration, freezing or other storage functions, such as refrigerators, freezers, etc.

[0093] Those skilled in the art should also understand that the terms "upper", "lower", "front", "back", "top", "bottom", etc. used to indicate orientation or positional relationships in the embodiments of the present invention are based on the actual usage status of the biological detection device 1 and the refrigerator 100. These terms are only used to facilitate the description and understanding of the technical solution of the present invention, and do not indicate or imply that the device or device referred to must have a specific orientation, be constructed and operated in a specific orientation. Therefore, they should not be understood as limiting the present invention.

[0094] At this point, those skilled in the art will appreciate that although specific exemplary embodiments of the application have been described herein, the present application also encompasses many other variations or modifications in accordance with the principles of the application as set forth above. Accordingly, the scope of the present application should be understood to include all such variations and modifications.

Claims

1. A bioassay chip for qualitatively and / or quantitatively detecting preset detection parameters of a sample, characterized in that: The biological detection chip comprises a plurality of detection channels arranged in parallel and independent of each other, each of the detection channels having a detection chamber for containing a detection reagent; Each detection channel further comprises a sampling chamber for providing a sample liquid to the detection chamber of the detection channel, and the sampling chambers of the detection channels are independent of each other; the sampling chamber is pre-filled with an extraction liquid, so that after the sample is placed in the sampling chamber, it mixes with the extraction liquid to produce a sample liquid; Each of the detection channels further comprises a reaction chamber for accommodating a reaction reagent, wherein the reaction chamber is located between the sampling chamber and the detection chamber, so as to allow the sample liquid in the sampling chamber to flow through the reaction chamber and then into the detection chamber; The bioassay chip is configured to drive the sample liquid in each sampling chamber to flow to the corresponding reaction chamber, or to drive the sample liquid in each reaction chamber to flow to the corresponding detection chamber; Each sampling chamber is provided with a sampling port for placing a sample on the outside thereof, so as to allow each sample loading structure of the biological detection device to push the sample placed on the corresponding sampling port into the corresponding sampling chamber when the biological detection chip is installed in the biological detection device; The bioassay chip is further configured to connect each fluid interface to a corresponding detection channel after being installed in the bioassay device, so that the bioassay device controls the fluid flow in each detection channel through the fluid interface.

2. The biological detection chip according to claim 1, characterized in that: The reaction reagent is pre-placed in the reaction chamber; and / or The reaction reagent is colloidal gold attached to the inner wall of the reaction chamber.

3. The biological detection chip according to claim 1, characterized in that The detection reagent is pre-placed in the detection chamber; and / or A test paper is provided in the detection chamber, the detection reagent is integrated on the test paper, and at least one side of the detection chamber is open or transparent.

4. The biological detection chip according to claim 1, characterized in that The plurality of detection channels are arranged side by side along the width direction of the biological detection chip, and each detection channel extends along the length direction of the biological detection chip; and The detection chambers of the plurality of detection channels are located on the same side of the biological detection chip in its length direction.

5. A biological detection device, characterized in that: Used to install the biological detection chip according to any one of claims 1 to 4, and comprising: The chip mounting portion is formed with a plurality of fluid interfaces corresponding to the plurality of detection channels of the biological detection chip, so that each of the fluid interfaces is connected to a corresponding detection channel after the biological detection chip is mounted on the chip mounting portion.

6. The biological detection device according to claim 5, characterized in that: Also includes: a driving mechanism having an output port; A connecting channel is also formed inside the chip mounting portion, one end of the connecting channel is connected to the output port, and the other end has a plurality of branch channels, and the plurality of branch channels are respectively connected to the plurality of fluid interfaces one by one, so as to simultaneously drive the fluids in the plurality of detection channels of the biological detection chip installed in the chip mounting portion through the driving mechanism.

7. A refrigerator, characterized in that: A biological detection device comprising any one of claims 5-6.

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