A 3D fluorescence tomography animal molecular imaging scanning device

Abstract

The present invention provides a 3D fluorescent tomography animal molecular imaging scanning device, comprising a shell, a transparent placement mechanism arranged in a scanning cavity opened inside the shell, and a scanning mechanism arranged in the scanning cavity and sleeved on the placement mechanism, the scanning mechanism comprising a lifting component arranged on the bottom wall of the scanning cavity, an adjusting component arranged on the lifting component, and a scanning piece arranged on the adjusting component; the adjusting component comprises a lifting seat with one end arranged on the lifting component through a rotating component and an end surface provided with a scanning port, and a moving piece arranged on the wall of the scanning port and moving on the wall, the moving piece being connected to the scanning piece; the opening of the scanning port is circular in shape; the present invention can conveniently perform a comprehensive scan on a living small animal, improve the imaging details of the living small animal, and ensure the accuracy of the imaging details.

Description

Technical Field

[0001] The present invention relates to the technical field of optical molecular imaging, in particular to a 3D fluorescent tomography animal molecular imaging scanning device. Background Art

[0002] In vivo bioluminescence imaging is a molecular and gene expression analysis and detection system developed in recent years. It consists of a sensitive CCD and its analysis software, and luciferase and luciferin as reporters. Using sensitive detection methods, researchers can directly monitor biological processes such as tumor growth and metastasis, the development of infectious diseases, and the expression of specific genes in living organisms. Small animal in vivo fluorescence imaging technology has become increasingly popular at home and abroad. More and more scientific researchers hope to use this technology to track and observe the growth of tumor cells in living animals and their response to drug treatment for a long time, and hope to observe the distribution and metabolism of fluorescently labeled peptides, antibodies, and small molecule drugs in the body. Compared with traditional technologies, in vivo fluorescence imaging technology does not require killing animals, and can track and image the same animal repeatedly for a long time, which can not only improve the comparability of data and avoid the impact of individual differences on test results; it can also understand the distribution and metabolism of markers in animals and avoid many shortcomings of traditional in vitro experimental methods; in particular, it can also use original ecological methods to study problems, that is, the research objects do not need to be labeled first, and then use fluorescent markers to study their behavior, and the observation results are true and reliable.

[0003] When conventional small animal living fluorescent imaging equipment is used to scan small animals, the living small animals are first fluorescently marked and then scanned. However, the existing scanning devices are not convenient for accurately scanning various positions of the small animals when scanning the small animals, resulting in inaccurate imaging details of the living small animals. Summary of the invention

[0004] In response to the above technical problems, the present invention provides a 3D fluorescence tomography animal molecular imaging scanning device, which can conveniently perform a comprehensive scan of living small animals, improve the imaging details of the living small animals, and ensure the accuracy of the imaging details.

[0005] To achieve the above-mentioned object, the present invention provides the following technical solution: a 3D fluorescence tomography animal molecular imaging scanning device, comprising a housing, a transparent placement mechanism disposed in a scanning cavity opened inside the housing, and a scanning mechanism disposed in the scanning cavity and sleeved on the placement mechanism, wherein the scanning mechanism comprises a lifting component disposed on the bottom wall of the scanning cavity, an adjusting component disposed on the lifting component, and a scanning member disposed on the adjusting component;

[0006] The adjustment component includes a lifting seat, one end of which is arranged on the lifting component through a rotating member and the end surface of which is provided with a scanning port, and a moving member arranged on the wall of the scanning port and moves on the wall, wherein the moving member is connected to the scanning member; the opening of the scanning port is circular in shape;

[0007] The transparent placement mechanism comprises a turntable arranged on the bottom wall of the scanning cavity, a height adjusting member arranged on the turntable, and a placement block arranged on the height adjusting member, a placement groove is provided on the upper end surface of the placement block, and the placement block is made of transparent material;

[0008] The height-adjusting member comprises a telescopic arm with a bottom end arranged on the turntable and a telescopic slot formed on the top end surface, a telescopic screw with a bottom end inserted into the telescopic slot, and a telescopic rod with a bottom end inserted into the telescopic slot and a top connection placement block and sleeved on the telescopic screw, wherein the telescopic rod is threadedly connected to the telescopic screw, and a limit block is arranged on the side of the telescopic rod, and the limit block is arranged in a limit slot formed on the inner wall of the telescopic slot in a vertical direction; the telescopic rod is made of a transparent material;

[0009] The lifting assembly includes two lifting screws vertically arranged on the bottom wall of the scanning chamber, and two lifting blocks respectively sleeved on different lifting screws and threadedly connected with the lifting screws, and the lifting blocks are connected to the side of the lifting seat through the rotating member;

[0010] The rotating member includes two rotating rods, one end of which is respectively arranged on the side of the lifting seat and the other end is respectively connected to different lifting blocks, a rotating gear sleeved on one of the rotating rods, and an adjusting motor arranged on the lifting block and the output end of which is connected to the adjusting gear, and the adjusting gear is meshed with the rotating gear.

[0011] Preferably, a connection port and a heat dissipation port are provided on the side of the shell, and a movable lifting plate is provided in the connection port; a heat dissipation plate is provided at the opening of the heat dissipation port, and a plurality of heat dissipation holes are provided on the heat dissipation plate; a filter is provided on the heat dissipation hole.

[0012] Preferably, the lifting seat is mounted on the placement block through a scanning port, and a ring-shaped driving groove is provided on the wall of the scanning port; the moving part includes a fixed rack and a driving block provided on the bottom wall of the driving groove, and a driving gear provided on the driving block and meshing with the fixed rack, and the driving gear is driven by a motor; the driving block is connected to the scanning part.

[0013] Preferably, a moving groove is provided on the side surface of the driving block, and a moving block connected to the driving block is arranged in the moving groove.

[0014] The beneficial effects of the present invention are as follows: by placing the living small animals directly on the transparent placing mechanism, and then using the scanning mechanism to perform a comprehensive scan on the small animals, a comprehensive scan of the living small animals is achieved, the details of the imaging of the small animals are improved, and the accuracy of the imaging details is ensured. Moreover, a comprehensive scan of the small animals can be achieved only by using the scanning device mechanism, and it is easy to use. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings:

[0016] Figure 1 This is a simplified structural diagram of the 3D fluorescence tomography animal molecular imaging scanning device proposed in the present invention.

[0017] Figure 2 This is a schematic diagram of the internal structure of the 3D fluorescence tomography animal molecular imaging scanning device proposed in the present invention.

[0018] Figure 3 It is a schematic diagram of the transparent placement mechanism and scanning mechanism of the present invention.

[0019] Figure 4 It is a schematic diagram of the lifting seat structure of the present invention.

[0020] Figure 5 It is a schematic diagram of the structure of the moving part of the present invention.

[0021] Figure 6 It is a schematic diagram of the transparent placement mechanism structure of the present invention.

[0022] Figure 7 It is a schematic diagram of the enlarged structure of point A of the present invention.

[0023] In the figure: 1. Shell; 2. Connecting port; 3. Lifting plate; 4. Heat sink; 5. Scanning chamber; 6. Lifting screw; 7. Lifting block; 8. Lifting seat; 9. Scanning piece; 10. Adjusting motor; 11. Adjusting gear; 12. Rotating gear; 13. Height-adjusting piece; 14. Placement block; 15. Placement slot; 16. Scanning port; 17. Driving slot; 18. Fixed rack; 19. Moving slot; 20. Driving block; 21. Driving gear; 22. Turntable; 23. Telescopic arm; 24. Telescopic slot; 25. Limiting slot; 26. Telescopic screw; 27. Telescopic rod. DETAILED DESCRIPTION

[0024] In order to make the technical means, creative features, objectives and effects of the present invention easy to understand, the present invention is further described below in conjunction with specific embodiments and drawings, but the following embodiments are only preferred embodiments of the present invention, not all. Based on the embodiments in the implementation mode, other embodiments obtained by those skilled in the art without creative work are all within the scope of protection of the present invention.

[0025] See also Figure 1-7 A 3D fluorescence tomography animal molecular imaging scanning device comprises a housing 1, a transparent placing mechanism disposed in a scanning cavity 5 opened inside the housing 1, and a scanning mechanism disposed in the scanning cavity 5 and sleeved on the placing mechanism, wherein the scanning mechanism comprises a lifting component disposed on the bottom wall of the scanning cavity 5, an adjusting component disposed on the lifting component, and a scanning member 9 disposed on the adjusting component;

[0026] The adjusting component includes a lifting seat 8, one end of which is arranged on the lifting component through a rotating member and the end face of which is provided with a scanning port 16, and a moving member arranged on the wall of the scanning port 16 and moves on the wall, and the moving member is connected to the scanning member 9; the opening of the scanning port 16 is circular in shape.

[0027] like Figure 1-7 As shown, the height of the scanning piece 9 can be adjusted by the lifting assembly, and the moving piece moves on the wall of the scanning port 16, thereby driving the scanning piece 9 to move in a circle in the scanning port 16 on the lifting seat 8, thereby facilitating the driving of the scanning piece 9 to perform a full scan of the living small animal, and the situation where the surface is not convenient for scanning in different directions and positions is avoided, thereby ensuring the accuracy of the scanning imaging details.

[0028] A connection port 2 and a heat dissipation port are provided on the side of the shell 1. A movable lifting plate 3 is provided in the connection port 2. A heat dissipation plate 4 is provided at the opening of the heat dissipation port, and a plurality of heat dissipation holes are provided on the heat dissipation plate 4. A filter screen is provided on the heat dissipation hole.

[0029] like Figure 1-2 As shown, the lifting plate 3 can slide up and down to close the connecting port 2, and the heat generated inside the shell 1 can be dissipated through the heat dissipation port, thereby avoiding heat accumulation inside the shell 1 and causing damage to the scanning mechanism inside the shell 1.

[0030] The transparent placement mechanism includes a turntable 22 arranged on the bottom wall of the scanning chamber 5, a height adjustment member 13 arranged on the turntable 22, and a placement block 14 arranged on the height adjustment member 13. A placement groove 15 is opened on the upper end surface of the placement block 14, and the placement block 14 is made of transparent material.

[0031] like Figure 2 , Figure 3 and Figure 6As shown, the placement block 14 is made of transparent material, so that when a living small animal is placed on the placement block 14 for scanning, the placement block 14 is avoided from blocking the small animal and incomplete scanning is avoided. The turntable 22 is driven by a stepper motor, so as to drive the placement block 14 and the living small animal on the placement block 14 to rotate together, so as to facilitate scanning of the small animal.

[0032] The height adjusting member 13 includes a telescopic arm 23 whose bottom end is arranged on the turntable 22 and whose top end face is provided with a telescopic groove 24, a telescopic screw 26 whose bottom end is passed through the telescopic groove 24, and a telescopic rod 27 whose bottom end is passed through the telescopic groove 24 and whose top end is connected to the placement block 14 and is sleeved on the telescopic screw 26. The telescopic rod 27 is threadedly connected to the telescopic screw 26, and a limit block is arranged on the side of the telescopic rod 27, and the limit block is arranged in a limit groove 25 opened on the inner wall of the telescopic groove 24 along the vertical direction; the telescopic rod 27 is made of transparent material.

[0033] like Figure 6 As shown, the telescopic rod 27 is made of transparent material to avoid blocking the small animal when scanning, so as to facilitate a detailed scan of the whole body of the small animal. A stepper motor connected to the telescopic screw 26 is provided at the bottom of the telescopic slot 24, so as to facilitate controlling the distance between the placement block 14 and the bottom wall of the scanning chamber 5. The limit block moves in the limit slot 25, so as to facilitate ensuring the stable lifting and lowering of the placement block 14.

[0034] The lifting assembly includes two lifting screws 6 vertically arranged on the bottom wall of the scanning chamber 5, and two lifting blocks 7 respectively sleeved on different lifting screws 6 and threadedly connected to the lifting screws 6. The lifting blocks 7 are connected to the side of the lifting seat 8 through a rotating member.

[0035] The rotating member includes two rotating rods, one end of which is respectively arranged on the side of the lifting seat 8 and the other end of which is respectively connected to different lifting blocks 7, a rotating gear 12 sleeved on one of the rotating rods, and an adjusting motor 10 arranged on the lifting block 7 and the output end of which is connected to the adjusting gear 11, and the adjusting gear 11 is meshed with the rotating gear 12.

[0036] like Figure 3 As shown, the regulating motor 10 also adopts a stepping motor, so as to facilitate the control of the rotation angle and the forward or reverse rotation of the lifting seat 8, so that the scanning part 9 arranged on the lifting seat 8 through the moving part can scan the whole body of the small animal.

[0037] The lifting seat 8 is sleeved on the placement block 14 through the scanning port 16, and a ring-shaped driving groove 17 is opened on the wall of the scanning port 16; the moving part includes a fixed rack 18 and a driving block 20 arranged on the bottom wall of the driving groove 17, and a driving gear 21 arranged on the driving block 20 and meshing with the fixed rack 18, and the driving gear 21 is driven by a motor; the driving block 20 is connected to the scanning part 9.

[0038] like Figure 1-7 As shown, by means of the rotating member and the driving member, the scanning member 9 can be driven to rotate in all directions around the small animal, so that the whole body of the small animal can be scanned and imaged through the scanning member 9, thereby realizing a comprehensive scan of the living small animal, improving the details of the imaging of the small animal, and ensuring the accuracy of the imaging details. The structure is simple, and the cost of the scanning device is reduced, so that it is easy to promote and use.

[0039] A moving groove 19 is formed on the side surface of the driving block 20 , and a moving block connected to the driving block 20 is disposed in the moving groove 19 .

[0040] like Figure 6 As shown, the moving block slides stably in the moving groove 19, thereby facilitating the driving block 20 to move stably in the driving groove 17.

[0041] The above shows and describes the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited by the above embodiments. The above embodiments and descriptions are only preferred examples of the present invention and are not intended to limit the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention. The scope of protection of the present invention is defined by the attached claims and their equivalents.

Claims

1. A 3D fluorescence tomography animal molecular imaging scanning device, comprising a housing (1), a transparent placement mechanism disposed in a scanning cavity (5) opened inside the housing (1), and a scanning mechanism disposed in the scanning cavity (5) and sleeved on the placement mechanism, characterized in that: The scanning mechanism comprises a lifting component arranged on the bottom wall of the scanning chamber (5), an adjusting component arranged on the lifting component, and a scanning element (9) arranged on the adjusting component; The adjustment component comprises a lifting seat (8) with one end arranged on the lifting component through a rotating member and having a scanning port (16) opened on the end surface, and a moving member arranged on the wall of the scanning port (16) and moving on the wall, wherein the moving member is connected to the scanning member (9); the opening of the scanning port (16) is circular in shape; The transparent placement mechanism comprises a rotating disk (22) arranged on the bottom wall of the scanning chamber (5), a height adjustment member (13) arranged on the rotating disk (22), and a placement block (14) arranged on the height adjustment member (13); a placement groove (15) is provided on the upper end surface of the placement block (14), and the placement block (14) is made of transparent material; The height-adjusting member (13) comprises a telescopic arm (23) whose bottom end is arranged on a rotating disk (22) and whose top end surface is provided with a telescopic groove (24), a telescopic screw (26) whose bottom end is passed through the telescopic groove (24), and a telescopic rod (27) whose bottom end is passed through the telescopic groove (24) and whose top end is connected to a placement block (14) and sleeved on the telescopic screw (26), wherein the telescopic rod (27) is threadedly connected to the telescopic screw (26), and a limit block is arranged on the side of the telescopic rod (27), wherein the limit block is arranged in a limit groove (25) provided on the inner wall of the telescopic groove (24) along the vertical direction; the telescopic rod (27) is made of a transparent material; The lifting assembly comprises two lifting screws (6) vertically arranged on the bottom wall of the scanning chamber (5), and two lifting blocks (7) respectively sleeved on different lifting screws (6) and threadedly connected to the lifting screws (6), and the lifting blocks (7) are connected to the side of the lifting seat (8) through the rotating member; The rotating member comprises two rotating rods, one end of which is respectively arranged on the side of the lifting seat (8) and the other end of which is respectively connected to different lifting blocks (7), a rotating gear (12) sleeved on one of the rotating rods, and an adjusting motor (10) arranged on the lifting block (7) and the output end of which is connected to an adjusting gear (11), and the adjusting gear (11) is meshed with the rotating gear (12).

2. A 3D fluorescence tomography animal molecular imaging scanning device according to claim 1, characterized in that: A connection port (2) and a heat dissipation port are provided on the side of the shell (1); a movable lifting plate (3) is provided in the connection port (2); a heat dissipation plate (4) is provided at the opening of the heat dissipation port, and a plurality of heat dissipation holes are provided on the heat dissipation plate (4); and a filter screen is provided on the heat dissipation hole.

3. The 3D fluorescence tomography animal molecular imaging scanning device according to claim 1, characterized in that: The lifting seat (8) is sleeved on the placement block (14) through a scanning port (16), and a ring-shaped driving groove (17) is opened on the wall of the scanning port (16); the moving part comprises a fixed rack (18) and a driving block (20) arranged on the bottom wall of the driving groove (17), and a driving gear (21) arranged on the driving block (20) and meshing with the fixed rack (18), and the driving gear (21) is driven by a motor; the driving block (20) is connected to the scanning part (9).

4. The 3D fluorescence tomography animal molecular imaging scanning device according to claim 3, characterized in that: A moving groove (19) is provided on the side surface of the driving block (20), and a moving block connected to the driving block (20) is arranged in the moving groove (19).

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