Adjustable and removable valve clamping device

Abstract

The present invention relates to the field of medical devices, and in particular to an adjustable and removable valve clamping device, the valve clamping device comprising a fixing portion and a spacer portion, the fixing portion comprising a support member, an anchor member and a connector, the spacer portion comprising a connected balloon body and a variable valve, the support member, the anchor member and the balloon body being all connected to the connector. The valve clamping device of the present invention can adapt to anatomical structures of various nonlinear sizes, expanding the scope of indications; it can provide a re-intervention interface after the anatomical dimensions around the mitral valve change after surgery, adjust the clamping distance and tension, thereby alleviating reflux caused by postoperative left ventricular remodeling and further prolonging the treatment effect; each component provides a reliable clamping structure and reduces reflux at the beginning of implantation, and some structures can degrade after a period of time after surgery, providing space for other treatment methods such as replacement that may be required for long-term prognosis.

Description

Technical Field

[0001] The present invention relates to the field of medical devices, and in particular to an adjustable and removable valve clamping device. Background Art

[0002] The heart contains four chambers: the right atrium (RA), right ventricle (RV), left atrium (LA), and left ventricle (LV). The pumping action of the left and right sides of the heart generally occurs synchronously throughout the cardiac cycle. The valves separating the atria from the ventricles are called the atrioventricular valves. They act as one-way valves, ensuring the normal flow of blood within the heart chambers. The atrioventricular valve between the left atrium and the left ventricle is the mitral valve, and the atrioventricular valve between the right atrium and the right ventricle is the tricuspid valve. The pulmonary valve directs blood flow to the pulmonary artery, and from there to the lungs; blood returns to the left atrium through the pulmonary veins. The aortic valve directs blood flow through the aorta, and from there to the pericardium. There are typically no direct connections between the ventricles or between the atria. At the beginning of ventricular filling (diastole), the aortic and pulmonary valves close to prevent backflow from the arteries into the ventricles. Shortly thereafter, the atrioventricular valves open to allow unimpeded flow from the atria into the corresponding ventricles. Shortly after the onset of ventricular systole, the tricuspid and mitral valves normally close, forming a seal that prevents backflow from the ventricles into the corresponding atria.

[0003] The mitral valve has a unique anatomy. The mitral valve comprises a pair of cusps or leaflets, the anterior and posterior leaflets. The cusps or leaflets extend downward from the annulus into the left ventricle. The mitral annulus can have a "D" shape, an oval shape, or other non-circular cross-sectional shape with a major and minor axis. The anterior leaflet can be larger than the posterior leaflet, forming a roughly "C"-shaped boundary between the adjacent sides of the leaflets when the leaflets are closed together. The mitral valve also includes an annulus, a dense, fibrous ring of tissue surrounding the leaflets. The mitral valve is anchored to the wall of the left ventricle by chordae tendineae. The chordae tendineae are bands of tendons that connect the papillary muscles to the leaflets of the mitral valve. The papillary muscles serve to limit the movement of the mitral valve and prevent it from retracting. The mitral valve opens and closes in response to pressure changes in the left atrium and left ventricle. Together, the papillary muscles and chordae tendineae are known as the subvalvular apparatus, which maintains the mitral valve from prolapsing into the left atrium when the valve is closed. Generally speaking, native valves can malfunction in two different ways: valvular stenosis and valvular regurgitation. Valvular stenosis occurs when the native valve does not open completely, resulting in blood flow obstruction. Typically, valvular stenosis is caused by the accumulation of calcified material on the valve leaflets, which causes the leaflets to thicken and impairs the valve's ability to fully open to allow forward blood flow. Valvular regurgitation is when the valve leaflets do not close completely, causing blood to leak back into the previous chamber.

[0004] For a normal mitral valve, the anterior and posterior leaflets together act as a one-way valve to allow blood to flow only from the left atrium to the left ventricle. The left atrium receives oxygenated blood from the pulmonary veins. When the left atrial muscle contracts and the left ventricle relaxes, the oxygenated blood collected in the left atrium flows into the left ventricle. When the left atrial muscle relaxes and the left ventricular muscle contracts, the elevated blood pressure in the left ventricle drives the two sides of the two leaflets together, thereby closing the one-way mitral valve so that blood cannot flow back into the left atrium and is instead discharged from the left ventricle through the aortic valve. To prevent the two leaflets from falling out under pressure and folding back toward the left atrium through the mitral annulus, multiple fibrous cords (called chordae tendineae) tie the leaflets to the papillary muscles of the left ventricle.

[0005] Mitral regurgitation occurs when the mitral valve fails to close properly and blood flows from the left ventricle into the left atrium during the systolic phase of the heart's contraction. Mitral regurgitation is the most common form of valvular heart disease. Mitral regurgitation has different causes, such as valve leaflet prolapse, papillary muscle dysfunction, and / or left ventricular dilation causing stretching of the mitral annulus. Heart valve regurgitation can have serious consequences for patients, often leading to heart failure, decreased blood flow, lowered blood pressure, and / or reduced oxygen flow to the body's tissues. Mitral regurgitation can also cause blood from the left atrium to flow back into the pulmonary veins, causing congestion. Severe valvular regurgitation, if left untreated, can lead to permanent disability or death.

[0006] Traditional treatments for valvular diseases include drug therapy and surgical methods with corresponding surgical indications. Among them, surgical methods also include valve replacement and valve repair. Among surgical methods, typical open-chest surgery is too invasive and requires the establishment of extracorporeal circulation, which has a high incidence of complications and infection risks. Many patients cannot tolerate the huge surgical risks and can only wait for death. There is a transcatheter treatment method that delivers a leaflet clamp to the mitral valve through a pushing device, and then the relative opening of the clamp simultaneously clamps the anterior and posterior leaflets of the mitral valve, so that the anterior and posterior leaflets of the mitral valve are fixed to achieve the purpose of reducing mitral valve regurgitation.

[0007] Although the clamping products used for mitral valve repair are constantly being optimized and upgraded, there is still room for improvement, such as:

[0008] 1. The causes of mitral regurgitation are complex and diverse, and the anatomical structures near the mitral valve vary greatly in size due to differences in patients' age, gender, race, weight, etc., while the sizes and models of existing mitral valve clip products are limited. Therefore, it is impossible to provide every patient with the most suitable product configuration, which will affect the surgical effect.

[0009] 2. Studies have shown that after an episode of functional mitral regurgitation, many patients experience symptoms of left ventricular enlargement. After mitral valve clamping, as the regurgitation is alleviated, the originally dilated left ventricle changes in size. Specifically, the length of the left ventricular major and minor axes, the annular diameter, and the stress and strain at the leaflet clamping site all change. This phenomenon can lead to the recurrence of regurgitation, necessitating further surgical intervention in severe cases. Existing techniques for clipping devices create a double-hole structure after implantation, making it impossible to perform a minimally invasive procedure (such as transcatheter prosthetic valve replacement) for further intervention. Summary of the Invention

[0010] In view of the above-mentioned shortcomings of the prior art, an object of the present invention is to provide an adjustable and removable valve clamping device to solve the problems in the prior art.

[0011] To achieve the above-mentioned objectives and other related objectives, the present invention provides an adjustable and removable valve clamping device, which includes a fixing portion and a spacer portion, wherein the fixing portion includes a support member, an anchor member and a connecting member, and the spacer portion includes a connected balloon body and a variable valve, and the support member, anchor member and balloon body are all connected to the connecting member.

[0012] As described above, the valve clamping device of the present invention has the following beneficial effects: it can adapt to anatomical structures of different sizes, and can be re-intervened when the anatomical dimensions around the mitral valve change after surgery; adjusting the clamping distance and tension can alleviate the reflux caused by postoperative left ventricular remodeling; each component provides a reliable clamping structure and reduces reflux at the beginning of implantation, and some structures can be degraded after a period of time after surgery, thereby providing space for transcatheter artificial valve replacement surgery, etc.; it can still be removed after many years of implantation. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 Shown is an overall schematic diagram of the valve clamping device of the present invention.

[0014] Figure 2 Shown is a schematic diagram of the fixing portion of the valve clamping device of the present invention.

[0015] Figure 3 Shown is a schematic diagram of the valve holding device of the present invention.

[0016] Figure 4 Schematic diagrams of balloons of different sizes in different scenarios of the valve clamping device of the present invention are shown, wherein the lower figures are top views of the upper figures.

[0017] Figure 5 Shown is a schematic diagram of the valve clamping device of the present invention clamping the native valve leaflet after implantation.

[0018] Figure 6It is a schematic diagram showing the degradation of the connector of the valve holding device of the present invention after being implanted in the body for a period of time.

[0019] Figure 7 It shows a schematic diagram of the valve holding device of the present invention after it is implanted in the body and the balloon body is separated from the native valve leaflet during replacement surgery.

[0020] Component number description

[0021] 1 Fixed part

[0022] 11 Support

[0023] 111 Sealing layer

[0024] 112 support frame

[0025] 12 Anchor

[0026] 13 Connectors

[0027] 2. Partition

[0028] 21 Balloon

[0029] 22 Variable valve

[0030] 3 Actuator

[0031] 31 Actuator filament

[0032] 32 Actuation line DETAILED DESCRIPTION

[0033] The following describes the implementation of the present invention through specific embodiments. People skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification.

[0034] See also Figures 1 to 7 . It should be noted that the structures, proportions, sizes, etc. illustrated in the drawings of this specification are only used to match the contents disclosed in the specification for people familiar with this technology to understand and read, and are not used to limit the limiting conditions for the implementation of the present invention. Therefore, they have no substantive technical significance. Any modification of the structure, change in the proportional relationship or adjustment of the size should still fall within the scope of the technical content disclosed by the present invention without affecting the efficacy and purpose that can be achieved by the present invention. At the same time, the terms such as "upper", "lower", "left", "right", "middle" and "one" quoted in this specification are only for the convenience of description, and are not used to limit the scope of the implementation of the present invention. Changes or adjustments in their relative relationships should also be regarded as the scope of the implementation of the present invention without substantially changing the technical content.

[0035] like Figure 1-7As shown, the present application provides a valve clamping device, which includes a fixing part 1 and a spacer part 2. The fixing part 1 includes a support member 11, an anchor member 12 and a connector 13. The spacer part 2 includes a balloon body 21. The proximal end of the balloon body 21 is provided with a variable valve 22. The support member 11, the anchor member 12 and the distal end of the balloon body 21 are all connected to the connector 13. The support member 11 and the anchor member 12 form a valve clamping structure relative to each other.

[0036] The proximal end refers to the end of the balloon body 21 that is not connected to the connector 13 , and the distal end refers to the end that is connected to the connector 13 .

[0037] like Figure 2 As shown, the support member 11 includes a sealing layer 111 and a support frame 112 , and the sealing layer 111 is provided on the surface of the support frame 112 .

[0038] In one embodiment, the sealing layer 111 is a sealing film.

[0039] In one embodiment, the material of the sealing film is selected from biodegradable materials. For example, chitin, polymalic acid, polylactic acid, L-polylactic acid, etc. In a preferred embodiment, the material of the sealing film is L-polylactic acid. L-polylactic acid has high strength, good plasticity, is easy to process and shape, is biodegradable and absorbable, and has good biocompatibility. The sealing film 111 can constrain the overall shape of the support frame 112 in the initial stage of implantation of the valve clamping device, and can help the support frame 112 maintain a fixed position during the implantation process. During the endothelialization process after implantation, the sealing film 111 gradually hydrolyzes into carbon dioxide and water. At this time, only the support frame 112 exists on the leaflets of the native valve.

[0040] In one embodiment, there are multiple support frames 112. For example, there are two support frames 112, which can be used for repairing the mitral valve and the tricuspid valve.

[0041] In such Figure 2 and 3 In the embodiment shown, two support frames 112 are provided, and both support frames 112 are connected to the connecting member 13. The two support frames 112 are symmetrically arranged on both sides of the connecting member 13.

[0042] In one embodiment, the support frame 112 is made of a metal material, preferably nickel-titanium alloy.

[0043] In one embodiment, the support frame 112 is a skeleton woven from dense metal wires (only sparse metal wires are used as an illustration in the figure). The support frame 112 provides a force for clamping and supporting the native valve leaflets.

[0044] The anchoring member 12 may be provided in multiple pieces, for example, two pieces, which can be used for repairing the mitral valve and the tricuspid valve.

[0045] In such Figure 2 and 3 In the illustrated embodiment, two anchoring pieces 12 are provided, and the two anchoring pieces 12 are symmetrically arranged on both sides of the connecting piece 13 .

[0046] The anchor 12 is used to anchor the native valve leaflet. In one embodiment, the anchor 12 is provided with barbs. The number of barbs may be 2 to 5.

[0047] One end of the anchoring member 12 is connected to the connecting member 13 .

[0048] Furthermore, the support member 11 is arranged on the outside, and the anchor member 12 is arranged on the inside. The inside refers to the side close to the spacer 2, that is, the side close to the central axis of the valve clamping device. The outside refers to the side away from the spacer 2, that is, the side away from the central axis of the valve clamping device. After implantation, the support member 11 and the anchor member 12 can cooperate to support the native leaflet, that is, the support member 11 is located on one side of the native leaflet, and the anchor member 12 is located on the other side of the native leaflet, and the two are clamped on the native leaflet.

[0049] In one embodiment, the material of the connector 13 is selected from biodegradable materials. For example, chitin, polymalic acid, polylactic acid, poly(L-lactic acid), etc. The material of the connector 13 is preferably poly(L-lactic acid). Poly(L-lactic acid) has good biocompatibility after degradation in the body, and is cheap and low in cost. After implantation, when the connector 13 degrades, only the support frame 112 of the extremely fine metal wire and the anchor 12 remain on the native leaflet, and there is no hard material connecting the native leaflets, and they can only be connected through endothelial tissue.

[0050] In such Figure 3 In the illustrated embodiment, the balloon body 21 has openings at the top and bottom, with a variable valve 22 provided at the top opening. The bottom opening of the balloon body 21 is sealed to the connector 13. After the connector 13 degrades, the bottom opening of the balloon body 21 is blocked by endothelial tissue, preventing leakage of the liquid inside the balloon body.

[0051] The balloon body 21 and the fixing portion 1 are located on the same side of the connecting member 13. The support member 11 and the anchor member 12 are provided on both sides of the balloon body 21, with the support member 11 located on the outside and the anchor member located on the inside. In other words, the balloon body 21 is provided on the side of the connecting member 13 where the fixing portion 1 is provided and is provided between the anchor members 12.

[0052] The arrangement of the balloon body 21 enables the balloon body 21 to be positioned in the heart valve orifice after the anchor 12 and the support 11 clamp the valve, thereby helping to fill the space and form a more effective seal.

[0053] The balloon body 21 has only one specification, but its size can be adjusted, such as Figure 4 The balloon bodies 21 of different sizes are shown. Those skilled in the art will appreciate that the size of the balloon body 21 can be adjusted based on the actual conditions of the patient.

[0054] The shape of the balloon 21 is not particularly limited in the present invention, and can be, for example, an ellipsoidal shape, a spindle shape, or the like.

[0055] The material of the balloon 21 is selected from flexible materials. For example, the balloon 21 made of a flexible nylon elastomer material can be compressed during implantation and introduced into the delivery system for assisting implantation. After being released by the delivery system, the balloon 21 can expand again. Moreover, the size of the balloon 21 can be adjusted according to the actual conditions of different patients.

[0056] The variable valve 22 is connected to the fluid passage lumen of the delivery system for the auxiliary implant. By rotating the variable valve 22, the size of the upper opening of the balloon body 21 can be adjusted, thereby opening or closing the fluid passage lumen. Liquid (e.g., saline) is injected into the balloon body 21 through the variable valve 22, and the volume of the balloon body 21 is adjusted by the amount of injected liquid. After injection, the variable valve 22 is rotated to close the balloon body 21 and disconnect it from the fluid passage lumen.

[0057] The volume of the balloon 21 is determined according to the patient's anatomical structure, such as the annular size and leaflet length. During the operation, the balloon 21 can be adjusted to the optimal size in real time according to the hemodynamic performance results under ultrasound.

[0058] The use of the variable valve 22 provides an interface for re-intervention. After the reflux level is reduced, the long axis and short axis of the left ventricle or right ventricle may be reduced, and the valve ring size may become smaller. Since the size of the valve leaflet itself will not change with the size of the valve ring or ventricle, the balloon size selected during the operation can no longer achieve the best therapeutic effect. At this time, re-intervention can be performed, the liquid cavity is connected to the variable valve 22, the variable valve 122 is opened, and the volume of the solution in the balloon 21 is adjusted to adapt to the reconstructed anatomical structure.

[0059] In one embodiment, the variable valve 22 is selected from Tuohy Borst Adapter. The variable valve 22 can adjust the diameter by rotating.

[0060] After implantation, the support member 11 and anchor 12 clamp the prolapsed portions of the anterior and posterior mitral leaflets together, while the spacer 2 fills the heart valve orifice, effectively eliminating or improving valvular regurgitation. This significantly alters the geometry of the mitral valve, creating a bicuspid mitral valve, improving leaflet coaptation and reducing or eliminating valvular regurgitation. The spacer 2 reduces tension at the clamping site, preventing leaflet tearing at the clamping site, while also providing a good seal and eliminating central regurgitation.

[0061] In one embodiment, the valve clamping device further includes an actuating portion 3 , which includes an actuating wire 31 and an actuating line 32 . The actuating wire 31 is passed through the fixing portion 1 and the spacer portion 2 , and the actuating line 32 is connected to one end of the anchor 12 .

[0062] Specifically, the actuating wire 31 is threaded through the variable valve 22 and the balloon body 21 to the connector 13. The actuating wire 31 is used to position the anchoring portion 1 and the spacer 2. Specifically, the actuating wire 31 is positioned so that the positions of the anchoring portion 1 and the spacer 2 can be adjusted by moving the actuating wire 31 during implantation. Upon implantation, the support member 11 of the anchoring portion 1 is positioned below the native leaflets, and the spacer 2 is positioned between the native leaflets.

[0063] In one embodiment, the actuating wire is a metal wire having a certain hardness, and when the metal wire is moved, the balloon body 21 and the connecting member 13 connected in series thereon can be moved quickly and accurately, thereby driving the support member 11 and the anchor member 12 to move.

[0064] In one embodiment, the actuation wire 32 is connected to the barbed end of the anchor 12. During implantation, the anchor 12 can be moved by adjusting the actuation wire 32 to move the anchor 12 closer to or further away from the native leaflet, thereby capturing or separating the native leaflet.

[0065] The valve clamping device of the present invention can be used for repairing heart valves, such as mitral valve and tricuspid valve.

[0066] Those skilled in the art are aware that the valve clamping device requires a delivery system to assist in the implantation, and the delivery system includes a delivery sheath, a fluid passage cavity, and a fluid passage cavity catheter.

[0067] The valve clamping device of the present invention is used as follows: the balloon body 21, the variable valve 22, and the actuating wire 31 are assembled before leaving the factory, and the anchor 12 is provided with a barbed end connected to the actuating wire 32. During use, there is no need to select the specifications of the balloon body 21 according to the patient's condition. The variable valve 22 is connected to the liquid cavity catheter, and the liquid is injected and aspirated to empty and fold the balloon body 21. The actuating wire 31 is pushed to axially extend the fixing part 1 and the spacer part 2 to compress them radially and introduce them into the delivery sheath. Through the inferior vena cava route, it is pushed out from the right atrium or left atrium, the fixing part 1 and the spacer part 2 are released, and the balloon body 21 is released. At this time, it is in a radially folded state, and the support member 11 is changed to an extended state. By pulling one or two actuating wires 32, the anchor 12 can be opened separately or simultaneously to capture the valve leaflets. The actuating wire 31 is moved along the axial direction of the actuating wire 31, thereby driving the fixing portion 1 and the spacer portion 2, and the support frame 112 is arranged on the lower side of the valve leaflet, and the anchor 12 is arranged on the upper side of the valve leaflet. The anchor 12 is anchored to the native leaflet by the actuating wire 32, and the balloon 21 is arranged between the native leaflets (such as Figure 5 As shown in the figure, the component between the anchor 12 and the support frame 112 is the native valve leaflet). The initial state of the variable valve 22 is the open state. A suitable volume of liquid is injected into the balloon body 21 through the liquid cavity to adjust the volume of the balloon body 21. The reflux situation is confirmed using imaging equipment such as transesophageal ultrasound. When the volume of the balloon body 21 reaches the optimal effect of reducing reflux, the actuating wire 31 is rotated to disengage the actuating wire 31 from the connector 13, and the actuating wire 31 is withdrawn from the balloon body 21 and the variable valve 22 in turn. Cut the actuating wire 32 and withdraw it. Rotate the liquid cavity catheter to adjust the variable valve 22 from the initial open state to the blocked state, withdraw the liquid cavity catheter, and complete the release of the valve clamping device. After the valve clamping device is implanted, the mitral valve regurgitation or tricuspid valve regurgitation can be effectively reduced.

[0068] After implantation, follow up according to the doctor's instructions. If new reflux is found, the above implantation method is repeated, and the delivery system without the valve clamping device is used to enter the implantation site. With the assistance of a snare or other tools, the liquid cavity catheter is reconnected to the variable valve 22, and the liquid cavity catheter is rotated to open the variable valve 22. The volume of the balloon is adjusted by injecting or aspirating liquid to eliminate the new reflux.

[0069] In the embodiment where the connector 13 and the sealing layer 111 are made of biodegradable materials, the sealing layer 111 and the connector 13 will gradually degrade after implantation, and eventually, only the support frame 112 fixed on the native leaflet, the anchor 12 and the balloon body 21 (such as Figure 6If a replacement surgery is required, the delivery system without the valve clamping device can be delivered to the implantation site. With the help of a snare or other tools, the variable valve 22 is connected, the balloon body 21 is fixed, and all the liquid in the balloon body 21 is sucked out of the body. The radiofrequency electrode catheter is used to cut the adhesion between the balloon body 21 and the native valve leaflet until the two are separated (such as Figure 7 The spacer 2 is removed and then the artificial valve is replaced, thereby further improving the patient's quality of life and prolonging the patient's life.

[0070] The above examples are intended to illustrate the embodiments disclosed herein and are not to be construed as limiting the present invention. In addition, the various modifications listed herein and variations of the methods in the invention will be apparent to those skilled in the art without departing from the scope and spirit of the present invention. Although the present invention has been specifically described in conjunction with various specific preferred embodiments of the present invention, it should be understood that the present invention should not be limited to these specific embodiments. In fact, various modifications apparent to those skilled in the art as described above to obtain the invention should be included within the scope of the present invention.

Claims

1. A valve clamping device, characterized in that: The valve clamping device comprises a fixing portion (1) and a spacer portion (2), wherein the fixing portion (1) comprises a support member (11), an anchor member (12) and a connector (13), wherein the spacer portion (2) comprises a balloon body (21), wherein a variable valve (22) is provided at the proximal end of the balloon body (21), wherein the distal ends of the support member (11), the anchor member (12) and the balloon body (21) are all connected to the connector (13), wherein the balloon body (21) and the fixing portion (1) are located on the same side of the connector (13), wherein the support member (11) is located on the outside and the anchor member (12) is located on the inside, wherein the material of the connector (13) is selected from biodegradable materials, wherein the support member (11) and the anchor member (12) are opposite to each other to form a valve clamping structure, wherein the support member (11) comprises a sealing layer (111) and a support frame (112), wherein the sealing layer (111) is provided on the support frame (112). The surface of the support frame (112) is a sealing film, and the material of the sealing film is a biodegradable material; the variable valve (22) is connected to the liquid passage cavity of the delivery system for auxiliary implantation, and the upper opening size of the balloon body (21) is adjusted by rotating the variable valve (22) to open or close the liquid passage cavity. The valve clamping device can be re-intervened when the anatomical size around the mitral valve changes after surgery, and the use of the variable valve (22) provides an interface for re-intervention; the valve clamping device also includes an actuating part (3), and the actuating part (3) includes an actuating wire (31) and an actuating line (32), the actuating wire (31) is connected to the connecting member (13) and the spacer (2), the actuating line (32) is connected to the proximal end of the anchor (12), and the actuating wire (31) is passed through the variable valve (22) and the balloon body (21) until the connecting member (13).

2. The valve clamping device according to claim 1, characterized in that: The fixing portion (1) comprises a plurality of support frames (112).

3. The valve clamping device according to claim 2, characterized in that: The fixing portion (1) comprises two support frames (112), and the two support frames (112) are symmetrically arranged on both sides of the connecting member (13).

4. The valve clamping device according to claim 1, characterized in that: One end of the anchoring piece (12) is connected to the connecting piece (13), and the other end is provided with a barb.

5. The valve clamping device according to claim 1, characterized in that: The fixing portion (1) comprises a plurality of anchoring pieces (12).

6. The valve clamping device according to claim 5, characterized in that: The fixing portion (1) comprises two anchoring pieces (12), and the two anchoring pieces (12) are symmetrically arranged on both sides of the connecting piece (13).

7. The valve clamping device according to claim 1, characterized in that: The support member (11) and the anchor member (12) are provided on both sides of the balloon body (21).

8. The valve clamping device according to claim 1, characterized in that: The material of the balloon body (21) is selected from flexible materials.

9. The valve clamping device according to claim 1, characterized in that: The actuating wire (31) is a metal wire.

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