Pest Control Mixture

Abstract

The present invention relates to a pest control mixture. The present invention relates to an insecticidal mixture, which comprises (a) spinetoram; and (b) a group A compound selected from the group consisting of fluazifop, pyriproxyfen, fluvalinate and a combination thereof.

Description

[0001] This application is a divisional application of the invention patent application with application number 201810140870.7, application date November 5, 2013, divisional submission date February 11, 2018, and invention name “Pest Control Mixture”. Field of the Invention

[0002] The present disclosure relates to pesticidal mixtures for use in pest control. Background of the Invention

[0003] Active agent mixtures are described in the literature. However, the control of pests does not always meet the requirements of agricultural practice. In addition, the effectiveness of the mixtures is not completely satisfactory in the field of pest control and / or toxicology and / or environmental effects.

[0004] Spinetoram is a semisynthetic spinosad. Spinetoram is 50–90% (2 R ,3a R ,5a R ,5b S ,9 S ,13 S ,14 R ,16a S ,16b R )-2-(6-deoxy-3- O -ethyl-2,4-di- O -methyl-α-L-pyranose mannosyl)-13-[(2 R ,5 S ,6 R )-5-(dimethylamino)tetrahydro-6-methylpyran-2-yloxy]-9-ethyl-2,3,3a,4,5,5a,5b,6,9,10,11,12,13,14,16a,16b-hexahydro-14-methyl-1 H - as -Indaceno[3,2- d ]oxacyclododecine-7,15-dione and 50–10% (2 S ,3a R ,5a S ,5b S ,9 S ,13 S ,14 R ,16a S ,16b S )-2-(6-deoxy-3- O -ethyl-2,4-di- O-methyl-α-L-pyranose mannosyl)-13-[(2 R ,5 S ,6 R )-5-(dimethylamino)tetrahydro-6-methylpyran-2-yloxy]-9-ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-4,14-dimethyl-1 H - as -Indaceno[3,2- d ] A mixture of oxacyclododecine-7,15-diones.

[0005] ["Compendium of Pesticide Common Names" available at: www.alanwood.net / pesticides / index.html].

[0006] Ethyl spinetoram has been described in US Pat. No. US 6,001,981. Ethyl spinetoram is also described in The E-Pesticide Manual (Version 5.0.1, 2010, 15th edition, editor: CDS Tomlin)), Entry number 783.

[0007]

[0008] Spinetoram: A mixture of 50–90% component (i); and 50–10% component (ii).

[0009] Insecticidal mixtures comprising spinosad have been described in WO 2010 / 052129, WO 2010 / 030501, US 6,444,667, US 6,686,387 and US 2006 / 0211655.

[0010] Insecticidal compositions and mixtures do not exert satisfactory controlling effects in some cases, and thus there is still a need to develop novel insecticidal mixtures having satisfactory controlling effects.

[0011] Therefore, it is very advantageous to provide novel insecticidal mixture combinations of ethyl spinetoram and various pesticides described in the present invention that have very good control effects on various pests, improve pest control, broaden the control spectrum and / or maintain favorable and reduced environmental or toxicological effects. Summary of the invention SUMMARY OF THE INVENTION

[0013] According to one aspect, there is provided an insecticidal mixture comprising (a) spinetoram; and (b) a Group A compound selected from novaluron, pyriproxyfen, tau-fluvalinate, and combinations thereof.

[0014] According to another aspect, there is provided an insecticidal composition comprising an insecticidal mixture and an agriculturally acceptable carrier, wherein the insecticidal mixture comprises (a) spinetoram; and (b) a Group A compound selected from the group consisting of noflufenacil, pyriproxyfen, fluvalinate and combinations thereof.

[0015] According to another aspect, there is provided a method for controlling pests in crops, the method comprising contacting the pests or a locus where the pests need to be controlled with an insecticidal mixture comprising (a) spinetoram; and (b) a Group A compound selected from the group consisting of flubenzuron, pyriproxyfen, fluvalinate, and combinations thereof.

[0016] According to another aspect, a kit is provided, comprising (a) at least one container comprising spinetoram; (b) at least one container comprising a Group A compound selected from the group consisting of flubendiamide, pyriproxyfen, fluvalinate, and combinations thereof; and (c) instructions for applying the spinetoram and the Group A compound to pests or to a location where pest control is desired.

[0017] According to yet another aspect, a kit is provided, comprising (a) at least one container comprising (i) spinetoram; and (ii) a Group A compound selected from the group consisting of fluazifop, pyriproxyfen, fluvalinate, and combinations thereof; and (b) instructions for applying the spinetoram and the Group A compound to pests or to a location where pests need to be controlled. DETAILED DESCRIPTION OF THE INVENTION

[0019] Before describing the present invention in detail, it may be helpful to provide definitions for certain terms used herein. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the present invention belongs.

[0020] The use of the terms "a", "an" and "the" and similar referents in the context of describing the invention (especially in the context of the following claims) are to be construed to cover both the singular and the plural, unless otherwise indicated herein or clearly contradicted by context.

[0021] As used herein, the term "crop" includes reference to whole plants, plant organs (eg, leaves, stems, twigs, roots, trunks, branches, buds, fruits, etc.), or plant cells.

[0022] As used herein, the term “ Propagation material ” is understood to mean all reproductive parts of a plant, such as seeds and spores, vegetative structures such as bulbs, corms, tubers, rhizomes, roots stems, basal shoots, runners and shoots.

[0023] According to one aspect, there is provided an insecticidal mixture comprising (a) spinetoram; and (b) a Group A compound selected from the group consisting of noflufenacil, pyriproxyfen, fluvalinate, and combinations thereof.

[0024] Spinetoram is 50–90% (2 R ,3a R ,5a R ,5b S ,9 S ,13 S ,14 R ,16a S ,16b R )-2-(6-deoxy-3- O -ethyl-2,4-di- O -methyl-α-L-pyranose mannosyl)-13-[(2 R ,5 S ,6 R )-5-(dimethylamino)tetrahydro-6-methylpyran-2-yloxy]-9-ethyl-2,3,3a,4,5,5a,5b,6,9,10,11,12,13,14,16a,16b-hexahydro-14-methyl-1 H - as -Indaceno[3,2- d ]oxacyclododecine-7,15-dione and 50–10% (2 S ,3a R ,5a S ,5b S ,9 S ,13 S ,14 R ,16a S ,16b S )-2-(6-deoxy-3- O -ethyl-2,4-di- O -methyl-α-L-pyranose mannosyl)-13-[(2 R ,5 S ,6 R)-5-(dimethylamino)tetrahydro-6-methylpyran-2-yloxy]-9-ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-4,14-dimethyl-1 H - as -Indaceno[3,2- d ] A mixture of oxacyclododecine-7,15-diones.

[0025] ["Compendium of Pesticide Common Names" available at: www.alanwood.net / pesticides / index.html].

[0026] Spinetoram is described in The E-Pesticide Manual (Version 5.0.1, 2010, 15th edition, editor: CDSTomlin)), Entry number 783.

[0027]

[0028] Spinetoram: A mixture of 50–90% component (i); and 50–10% component (ii).

[0029] In The E-Pesticide Manual (Version 5.0.1, 2010, 15th edition, editor: CDSTomlin), Entry number 621, fluazifop ((±)-1-[3-chloro-4-(1,1,2-trifluoro-2-trifluoromethoxyethoxy)phenyl]-3-(2,6-difluorobenzoyl)urea) is described.

[0030] .

[0031] Fluvalinate (( RS )- N -(2-chloro-α,α,α-trifluoro- p -methylphenyl)-D-valine α-cyano-3-phenoxybenzyl ester)

[0032] ,

[0033] Pyriproxyfen (4-phenoxyphenyl ( RS )-2-(2-pyridyloxy)propyl ether)

[0034] .

[0035] These compounds are also described in the "Compendium of Pesticide Common Names" available at www.alanwood.net / pesticides / index.html 。

[0036] According to another aspect, there is provided a pesticidal composition comprising the pesticidal mixture as described in the present disclosure; and an agriculturally acceptable carrier.

[0037] According to certain embodiments, the pesticidal mixture can provide synergistic pesticidal activity when applied to pests.

[0038] The synergistic effect can be calculated as described in the article by Colby SR entitled "Calculating synergistic and antagonistic responses of herbicide combinations" published in the journal Weeds, 1967, 15, pp. 20-22 (the entirety of which is incorporated herein by reference).

[0039] Compared to the use of each of such pesticides alone, the pesticidal composition comprising the mixture as described in the present disclosure can improve the efficacy of pesticidal activity, can broaden the control spectrum and / or can minimize the use dosage of the active ingredient.

[0040] According to a particular embodiment, the pest is selected from insects, mites, molluscs or a combination thereof.

[0041] In one embodiment, the pest is an insect. In one embodiment, the pest is a mite. In one embodiment, the pest is a mollusk.

[0042] The term "insecticide" relates in particular to insecticidal and / or acaricidal activity. The term "insecticide" also relates to molluscicidal activity.

[0043] According to another aspect, a synergistic insecticidal mixture is provided, comprising (a) spinetoram; and (b) a Group A compound selected from the group consisting of noflufenacil, pyriproxyfen, fluvalinate, and combinations thereof.

[0044] According to another aspect, there is provided a pesticidal composition comprising a synergistically effective amount of the pesticidal mixture as described in the present disclosure; and an agriculturally acceptable carrier.

[0045] The composition can be used to control agricultural pests in crops or their loci, which comprises contacting the agricultural pests or the food supply, habitat, breeding ground or locus of the agricultural pests with an effective amount of the mixture as described in the present disclosure.

[0046] According to another aspect, there is provided a method for controlling pests in crops, comprising contacting the pests or a locus in need of pest control with an insecticidal mixture comprising (a) spinetoram; and (b) a Group A compound selected from the group consisting of flubenzuron, pyriproxyfen, fluvalinate, and combinations thereof.

[0047] According to another aspect, there is provided a method of controlling pests in crops, comprising contacting the pests or a locus in need of pest control with a composition comprising a pesticidal mixture as described in the present disclosure.

[0048] The location may be soil or water where crops are grown.

[0049] The present disclosure further relates to a method of controlling pests in crops or propagation material thereof, comprising contacting a food supply, habitat, breeding ground or locus of the pest or agricultural pest with an amount of a pesticidal mixture as described in the present disclosure.

[0050] According to certain embodiments, the weight ratio of spinetoram to a compound of Group A selected from flubendiamide, pyriproxyfen, fluvalinate, and combinations thereof is from 1:1000 to 1000:1. In one embodiment, the weight ratio of spinetoram to the compound of Group A is from 1:100 to 100:1. In another embodiment, the weight ratio of spinetoram to the compound of Group A is from 1:50 to 50:1. In yet another embodiment, the weight ratio of spinetoram to the compound of Group A is from 1:10 to 10:1. In another embodiment, the weight ratio of spinetoram to the compound of Group A is from 1:8 to 8:1. In another embodiment, the weight ratio of spinetoram to the compound of Group A is from 1:5 to 5:1.

[0051] According to some embodiments, the weight ratio of spinetoram to a compound of Group A selected from fluazifop, pyriproxyfen, fluvalinate and combinations thereof is 100:1 and lower, 50:1 and lower, 10:1 and lower, 8:1 and lower, 5:1 and lower, 4:1 and lower, 3:1 and lower, 2:1 and lower, 1.3:1 and lower, 1:1 and lower.

[0052] According to some embodiments, the weight ratio of spinetoram to the Group A compound selected from fluazifop, pyriproxyfen, fluvalinate and combinations thereof is 1:100 and higher, 1:50 and higher, 1:10 and higher, 1:8 and higher, 1:5 and higher, 1:4 and higher, 1:3 and higher, 1:2 and higher, 1:1.3 and higher, 1:1 and higher.

[0053] The weight ratio of spinetoram to the Group A compound selected from fluazifop, pyriproxyfen, fluvalinate and combinations thereof can be within the range between any of the above indicated values ​​(e.g., 4:1 to 1:4, 4:1 to 1:3, 4:1 to 1:2, 4:1 to 1:1.3, 4:1 to 1:1, 3:1 to 1:4, etc.).

[0054] As used herein, the term “ ha” It refers to hectares.

[0055] According to certain embodiments, spinetoram is applied at an rate of 0.5 grams per hectare ("g / ha") to 500 g / ha, particularly 1 g / ha to 500 g / ha, especially 1 g / ha to 250 g / ha, more especially 1 g / ha to 100 g / ha.

[0056] According to certain embodiments, the application rate of spinetoram is 0.5 g / ha and higher, 1 g / ha and higher, 1.5 g / ha and higher, 2 g / ha and higher, 2.5 g / ha and higher, 3 g / ha and higher, 3.5 g / ha and higher, 4 g / ha and higher, 4.5 g / ha and higher, 5 g / ha and higher, 5.5 g / ha and higher, 6 g / ha and higher.

[0057] According to certain embodiments, the application rate of spinetoram is 500 g / ha and less, 250 g / ha and less, 200 g / ha and less, 150 g / ha and less, 100 g / ha and less, 50 g / ha and less, 20 g / ha and less, 10 g / ha and less, 8 g / ha and less.

[0058] The application rate of spinetoram can be any range between any of the above indicated values.

[0059] According to certain embodiments, the application rate of the Group A compound is 0.5 g / ha to 500 g / ha, especially 1 g / ha to 500 g / ha, especially 1 g / ha to 250 g / ha, more especially 1 g / ha to 100 g / ha.

[0060] According to certain embodiments, the application rate of Group A compound is 0.5 g / ha and higher, 1 g / ha and higher, 1.5 g / ha and higher, 2 g / ha and higher, 2.5 g / ha and higher, 3 g / ha and higher, 3.5 g / ha and higher, 4 g / ha and higher, 4.5 g / ha and higher, 5 g / ha and higher, 5.5 g / ha and higher, 6 g / ha and higher.

[0061] According to certain embodiments, the application rate of Group A compound is 500 g / ha and less, 250 g / ha and less, 200 g / ha and less, 150 g / ha and less, 100 g / ha and less, 50 g / ha and less, 20 g / ha and less, 10 g / ha and less, 8 g / ha and less.

[0062] The application amount of the Group A compound selected from noflufenacil, pyriproxyfen and fluvalinate may be any range between any of the above indicated values.

[0063] According to certain embodiments, the application amount of the pesticidal mixture as described in the present disclosure is 1 g / ha to 1000 g / ha. In a specific embodiment, the application amount of the pesticidal mixture as described in the present disclosure is 2 g / ha to 1000 g / ha.

[0064] In another embodiment, the application rate of the combination (mixture) of spinetoram and a compound of Group A is from 1 g / ha to 500 g / ha. In yet another embodiment, the application rate of the combination of spinetoram and a compound of Group A is from 1 g / ha to 250 g / ha. In yet another embodiment, the application rate of the combination of spinetoram and a compound of Group A is from 1 g / ha to 200 g / ha. In yet another embodiment, the application rate of the combination of spinetoram and a compound of Group A is from 1 g / ha to 150 g / ha. In yet another embodiment, the application rate of the combination of spinetoram and a compound of Group A is from 1 g / ha to 100 g / ha. In yet another embodiment, the application rate of the combination of spinetoram and a compound of Group A is from 1 g / ha to 50 g / ha. The above ranges refer to the application rate of the combination of spinetoram and a compound of Group A (i.e., the sum of the application rates of these two active ingredients).

[0065] In one embodiment, spinetoram and the Group A compound are administered concomitantly or sequentially.

[0066] Spinetoram and the Group A compound may be administered in any desired order.

[0067] The term "sequential administration" means that a composition comprising spinetoram is sequentially administered followed by a composition comprising a Group A compound. When administered sequentially, spinetoram and the Group A compound are included in separate compositions. If spinetoram and the Group A compound are administered sequentially, their order of administration may be interchanged.

[0068] The term "simultaneous administration" or "concomitant administration" means that the compounds are administered substantially at the same time. These terms include not only the administration of spinetoram and Group A compounds of the present invention in a single formulation (composition), but also the administration of each compound (i.e. spinetoram and Group A compounds) in its own separate formulation. When separate formulations are used, the compounds may be administered substantially simultaneously, i.e. in parallel.

[0069] The application may be by any method known in the art, in particular by methods such as spraying, dipping, dusting, dressing, coating and soaking.

[0070] The present disclosure further relates to the use of a composition comprising a pesticidal mixture as described in the present disclosure for controlling pests in crops or their loci.

[0071] The present disclosure also relates to a composition comprising the pesticidal mixture as described in the present disclosure for controlling pests in crops or their loci.

[0072] In one embodiment, the pesticidal mixture is in a synergistically effective amount.

[0073] The crops include, but are not limited to, vegetables, fruits, soybeans, tobacco, cultivated mushrooms, cotton, rapeseed, cereals, sunflowers, peanuts, rice, corn, coffee, beans, peas, yucca, sugar cane, alfalfa, spice crops, ornamental plants, cocoa, and sugar beets.

[0074] In one embodiment, the crop can be vegetables such as peppers, cabbage, broccoli, asparagus, artichokes, squash, lettuce, turnips, spinach, cauliflower, melon, watermelon, cucumber, carrot, onion, garlic, gourd and potato; fruits, such as pome and stone fruits and berries, such as walnuts, kiwis, bananas, avocados, olives, passion fruit, apricots, pineapples, apples, pears, plums, peaches and cherries, tropical and subtropical fruits, table and wine grapes, citrus fruits, such as oranges, lemons, grapefruits and limes; cereals, such as wheat, barley, rye, triticale, oats, sorghum; corn (maize), such as sweet corn; beets, such as sugar beets, fodder beets; spice crops, such as cardamom; ornamental plants, such as flowers, Christmas trees.

[0075] In another embodiment, the insect pest is of the order Coleoptera, such as Acanthoscelides spp. (weevils), Acanthoscelides obtectus (common bean weevil), Agrilus planipennis (emerald ash borer), Agriotes spp. (wireworms), Anoplophora glabripennis (Asian longhorn beetle), Anthonomus spp. (weevils), Anthonomus grandis (cotton boll weevil), Aphidius spp., Apion spp. (weevils), Apogonia spp. (grubs), Ataenius spretulus (Black Turgrass Ataenius), Atomaria linearis (pygmymangold beetle), Aulacophore spp., Bothynoderes punctiventris (beetroot weevil), Bruchus spp. (weevils), Bruchus pisorum (pea weevil), Cacoesia spp., Callosobruchus maculatus (southern cow pea weevil), Carpophilus hemipteras (dried fruit beetle), Cassida vittata, Cerosterna spp., Cerotoma spp. (leaf beetles), bean leaf beetle, Ceutorhynchus spp. (weevils), Ceutorhynchus assimilis (cabbage weevil), Ceutorhynchus napi (turnip weevil), Chaetocnema spp.) (Leaf Beetles), Colaspis spp.(soil beetle), Conoderus scalaris, Conoderus stigmosus, Conotrachelus nenuphar (plum cone weevil), Cotinus nitidis (green beetle), Crioceris asparagi (asparagus leaf beetle), Cryptolestes ferrugineus (rusty red flat grain beetle), Cryptolestes pusillus (long-horned flat grain beetle), Cryptolestes turcicus (Turkish flat grain beetle), Ctenicera spp. (wireworms), Curculio spp. (weevils), Cyclocephala spp. (grubs), Cylindrocpturus adspersus (sunflower stem weevil), Deporaus marginatus (mango leaf cutter), Dermestes lardarius (ham skin beetle), Dermestes maculates (white-bellied skin beetle), Diabrotica spp. (leaf beetles), Epilachna varivestis (Mexican bean beetle), Faustinus cubae (tobacco borer), Hylobius pales (pale bark weevil), Hypera spp. (weevils), Hypera postica (alfalfa weevil), Hyperdoes spp. (Hyperodes weevil), Hypothenemus hampei (coffee berry borer), Ips spp. (engravers), Lasioderma serricorne (tobacco beetle), Leptinotarsa ​​decemlineata (Colorado potato beetle), Liogenys futscus, Liogenys suturalis, Lissorhoptrus oryzophilus (rice water weevil), Lyctus spp. (wood beetles / powder retainer beetles), Maecolaspis joliveti, Megascelis spp., corn beetles (Melanotus communis), cauliflower beetles (Meligethes spp.), Meligethes aeneus (flower beetle), Melolontha melolontha (common European beetle), Oberea brevis, Oberea linearis, Oryctes rhinoceros (date palm beetle), Oryzaephilus mercator (big-eyed grain beetle), Oryzaephilus surinamensis (saw grain beetle), Otiorhynchus spp. (weevils), Oulema melanopus (cereal leaf beetles), Oulema oryzae, Pantomorus spp. (weevils), Phyllophaga spp. (May / June beetles), Phyllophaga cuyabana, Phyllotreta spp. (leaf beetles), Phynchites spp., Popillia japonica (Japanese beetle), Prostephanus truncates (large grain borer), Rhizopertha dominica (grain borer), Rhizotrogus spp. (European scarab beetle), Rhynchophorus spp. (weevil), Scolytus spp. (wood beetle), Shenophorus spp. (beak beetle), Sitona lineatus (gray bean weevil), Sitophilus spp. (grain weevil), Sitophilus granaries (grain weevil), Sitophilus oryzae (rice weevil), Stegobium paniceum (herb beetle), Tribolium spp. (flour beetle), Tribolium castaneum (red flour beetle), Tribolium confusum (various flour beetle), Trogoderma variabile (warehouse beetle), and Zabrus tenebioides.

[0076] In yet another embodiment, the insect pests are of the order Diptera, such as Aedes spp. (mosquitoes), Agromyza frontella (alfalfa leafminer), Agromyza spp. (leafminers), Anastrepha spp. (fruit flies), Anastrepha suspensa (Caribbean fruit flies), Anopheles spp. (mosquitoes), Batrocera spp. (fruit flies), Bactrocera cucurbitae (cucumber fruit flies), Bactrocera dorsalis (Oriental fruit flies), Ceratitis spp. (fruit flies), Ceratitis capitata (Mediterranean fruit flies), Chrysops spp. (spotted flies), Cocliliomyia spp. (screwworms), Contarinia spp. ( spp.) (gall midges), Culex spp. (mosquitoes), Dasineura spp. (gall midges), Dasineura brassicae (cabbage gall midges), Delia spp., Delia platura (seedcorn maggots), Drosophila spp. (vinegar flies), Fannia spp. (house flies), Fannia canicularis (summer toilet flies), Fannia scalaris (gray-bellied toilet flies), Gasterophilusintestinalis (horse flies), Gracillia perseae, Haematobia irritans (horn flies), Hylemyia spp. (root maggots), Hypoderma lineatum (common cattle grubs), Liriomyza spp. (spotted fly mining), Liriomyza brassica (American leafminer), Melophagusovinus (sheep tick), Musca spp. (Muscidae), Musca autumnalis (autumn housefly), Musca domestica (common housefly), Oestrus ovis (sheep fly), Oscinella frit (yellow leafminer), Pegomyia betae (beet leafminer), Phorbia spp.), Psila rosae (carrot rust fly), Rhagoletis cerasi (cherry fruit fly), Rhagoletis pomonella (apple fruit fly), Sitodiplosis mosellana (wheat midge), Stomoxys calcitrans (stable fly), Tabanus spp. (horse flies), and Tipula spp. (crane flies).

[0077] In yet another embodiment, the insect pests are of the order Hemiptera, such as Acrosternum hilare (green rice stink bug), Blissus leucopterus (wheat stink bug), Calocoris norvegicus (potato mirid), Cimex hemipterus (tropical stink bug), Cimex lectularius (bed bug), Dichelops melacanthus (Dallas), Dagbertus fasciatus, Dichelops furcatus, Dysdercus suturellus (cotton stink bug), Edessameditabunda, Eurygaster maura (cereal bug), Euschistus heros, Euschistus servus (brown stink bug), Helopeltis antonii, Helopeltis theivora (tea blight bug), Lagynotomus spp. (stink bug), Leptocorisa oratorius, Leptocorisa varicornis), Lygus spp. (blind bugs), Lygus hesperus (western pasture blind bug), Maconelli coccushirsutus, Neurocolpus longirostris, Nezara viridula (green rice stink bug), Paratrioza cockerelli, Phytocoris spp. (blind bugs), Phytocoris californicus, Phytocoris relativus, Piezodorus guildingi, Poecilocapsus lineatus (four-lined blind bug), Psallus vaccinicola, Pseudacysta perseae, Scaptocoris castanea, and Triatoma spp. (blood-sucking trypanosomes / assassin bugs).

[0078] In yet another embodiment, the insect pests are of the order Homoptera, such as Acrythosiphon pisum (pea aphid), Adelges spp. (aphids), Aleurodes proletella (cabbage whitefly), Aleurodicus disperses, Aleurothrixus floccosus (soft-haired whitefly), Aluacaspis spp., Amrasca bigutella bigutella, Aphrophora spp. (leafhoppers), Aonidiella aurantii (red round scale), Aphis spp. (aphids), Aphis gossypii (cotton aphid), Aphis fabae (aphids), Aphis pomi (apple aphid), Aulacorthum solani (foxglove aphid), Bemisia spp. (whiteflies), Bemisia whitefly (whiteflies), argentifolii), Bemisia tabaci (sweet potato whitefly), Brachycolus noxius (Russian aphid), Brachycorynella asparagi (asparagus aphid), Brevennia rehi, Brevicoryne brassicae (cabbage aphid), Ceroplastes spp. (scale), Ceroplastes rubens (red wax scale), Chionaspis spp. (scale), Chrysomphalus spp. (scale), Coccus spp. (scale), Dysaphis plantaginea (rose apple aphid), Empoasca spp. (leafhoppers), Eriosoma lanigerum (wool apple aphid), Icerya purchasi (wool blowing scale), Idioscopus nitidulus (mango leafhopper), Laodelphax striatellus (small brown planthopper), Lepidosaphes spp., Macrosiphum spp.), Macrosiphum euphorbiae (potato aphid), Macrosiphum granarium (wheat aphid), Macrosiphum rosae (rose aphid), Macrostelesquadrilineatus (aster leafhopper), Mahanarva frimbiolata, Metopolophium dirhodum (wheat aphid), Mictis longicornis, Myzus persicae (myzus persicae), Nephotettix spp. (leafhoppers), Nephotettix cinctipes (green leafhopper), Nilaparvata lugens (brown planthopper), Parlatoria pergandii (bran scale), Parlatoria ziziphi (black scale), Peregrinus maidis (corn wax cicada), Philaenus spp. (foam cicada), Phylloxera vitifoliae (grape phylloxera), Physokermes piceae (spruce aphid wax scale), Planococcus spp. (mealy scale), Pseudococcus spp. (mealy scale), Pseudococcus brevipes (pineapple mealy scale), Quadraspidiotusperniciosus (pear round shield scale), Rhapalosiphum spp. (aphids), Rhapalosiphum maida (corn leaf aphid), Rhapalosiphum padi (grain aphid), Saissetia spp. (scale), Saissetiaoleae (black round scale), Schizaphis graminum (wheat aphid), Sitobion avenae (wheat long-tube aphid), Sogatella furcifera (white-backed planthopper), Therioaphis spp. (aphids), Toumeyella spp. (scale flies), Toxoptera spp. (aphids), Trialeurodes spp. (whiteflies), Trialeurodes vaporariorum (greenhouse whitefly), Trialeurodes abutiloneus (banded-winged whitefly), Unaspis spp. (scale flies), Unaspis yanonensis (arrow-shaped scale flies), and Zulia entreriana.

[0079] In yet another embodiment, the insect pest is of the order Lepidoptera, such as Achoea janata, Adoxophyes spp., Adoxophyes orana, Agrotis spp. (cutworms), Agrotis ipsilon (small cutworm), Alabama argillacea (cotton leafworm), Amorbiacuneana, Amyelosis transitella (navel orange borer), Anacamptodes defectaria, Anarsia lineatella (peach moth), Anomis sabulifera (jute looper), Anticarsiagemmatalis (velvet bean caterpillar), Archips argyrospila (fruit leaf folder), Archips rosana (rose leaf folder), Argyrotaenia spp. (leaf folder), Argyrotaenia citrine (orange leaf folder), torrid), Autograph gamma, Bongos crunodes, Bourbon cinnabar (rice leaf folder), Bucculatrix thurberiella (cotton leaf miner), Caloptilia spp. (leaf miner), Capua reticulana, Carposina niponensis (peach borer), Chilo spp., Chlumetia transversa (mango leafworm), Choristoneura rosaceana (rose leaf folder), Chrysodeixis spp., Cnaphalocerus medinalis (grass leaf folder), Colias spp., Conpomorpha cramerella, Cossus cossus (wood borer), Crambus spp. (meadow borer), Cydia funebrana (plum borer), Cydia molesta (pear borer), Cydia nignicana (pea moth), Cydia pomonella (codling moth), Darna diducta, Diaphania spp. (borers), Diatraea spp.)(stalk borers), Diatraea saccharalis (sugarcane borer), Diatraea graniosella (southwestern corn stalk borer), Earias spp. (stem borers), Earias insulata (Egyptian bollworm), rough northern bollworm, Ecdytopopha aurantianum, Elasmopalpus lignosellus (small corn stalk borer), Epiphysias postruttana (apple light brown leaf roller), Ephestia spp. (meal borers), Ephestia cautella (meal borer), Ephestia elutella (tobacco mealybug), Ephestia kuehniella (Mediterranean mealybug), Epimeces spp., Epinotia aporema, Erionota thrax (banana butterfly), Eupoecilia ambiguella (grape leaf roller), Euxoa auxiliaris (original cutworm), Feltia spp. (cutworm), Gortyna spp. (stem borer), Grapholita molesta (pear borer), Hedylepta indicata (soybean leaf roller), Helicoverpaspp. (south armyworm), Helicoverpa armigera (cotton bollworm), Helicoverpa zea (corn bollworm), Heliothis spp. (south armyworm), Heliothis virescens (tobacco budworm), Hellula undalis (cabbage borer), Indarbela spp. (root borer), Keiferia lycopersicella (tomato stem moth), Leucino desorbonalis (eggplant borer), Leucoptera malifoliella, Lithocollectis spp., Lobesia botrana (grape fruit moth), Loxagrotis spp. (south armyworms), Loxagrotis albicosta (western bean armyworm), Lymantria dispar (gypsy moth), Lyonetia clerkella (apple leafminer), Mahasena corbetti (oil palm knotworm), Malacosoma spp.) (yellow-brown tent caterpillar), Mamestra brassicae (cabbage armyworm), Maruca testulalis (bean pod borer), Metisa plana (moth moth), Mythimna unipuncta (true armyworm), Neoleucinodes elegantalis (small tomato borer), Nymphuladepunctalis (rice stem borer), Operophthera brumata (winter moth), Ostrinia nubilalis (European corn borer), Oxydia vesulia, common currant tortrix, Pandemis heparana (apple leaf roller), Papilio demodocus, Pectinophora gossypiella (pink bollworm), Peridroma spp. (cutworm), Peridroma saucia (snow moth), Perileucopteracoffeella (coffee moth), Phthorimaea operculella (potato tuber moth), Phyllocnisitis citrell, Phyllonorycter spp. (leaf miners), Pieris rapae (cabbage butterfly), Plathypena scabra, Plodia interpunctella (Indian meal moth), Plutellaxylostella (diamondback moth), Polychrosis viteana (grape leaf roller), Prays endocarpa, Praysoleae (olive nest moth), Pseudaletia spp. (south moth), Pseudaletia unipunctata (army worm), Pseudoplusia includens (soybean leaf moth), Rachiplusia nu, Scirpophagaincertulas, Sesamia spp. (stem borers), Sesamia inferens (rice powdery stem borer), Sesamianonagrioides, Setora nitens, Sitotroga cerealella (wheat moth), Sparganothis pilleriana (grape moth), Spodoptera spp.) (armyworm), Spodoptera exigua (beet armyworm), Spodoptera fugiperda (fall armyworm), Spodoptera littoralis (cotton leafworm), Spodoptera oridania (southern armyworm), Synanthedon spp. (root borers), Thecla basilides, Thermisia gemmatalis, Tineola bisselliella (bagworm), Trichoplusia ni (cabbage cutworm), Tuta absoluta, Yponomeuta spp., Zeuzera coffeae (red twig borer), and Zeuzera pyrina (leopard borer).

[0080] In yet another embodiment, the insect pests are of the order Orthoptera, such as Anabrus simplex (Mormon katydid), Gryllotalpidae (mole crickets), Locusta migratoria, Melanoplus spp. (grasshoppers), Microcentrum retinerve (horn-winged katydid), Pterophylla spp. (katydids), chistocerca gregaria, Scudderia furcata (fork-tailed bush katydid), and Valanganigricorni.

[0081] In yet another embodiment, the insect pest is of the order Thysanoptera, such as Frankliniella fusca (tobacco flower thrips), Frankliniella occidentalis (western flower thrips), Frankliniellashultzei, Frankliniella williamsi (corn thrips), Heliothrips haemorrhaidalis (greenhouse thrips), Riphiphorothrips cruentatus, Scirtothrips spp., Scirtothrips citri (orange thrips), Scirtothrips dorsalis (orange thrips), Taeniothrips rhopalantennalis, and Thrips spp.

[0082] The mite may be, for example, a red spider mite ( Tetranychus urticae )、Apple Red Spider( Panonychus ulmi)、Citrus red spider ( Panonychus citri )、Rust Mites( Aceria anthocoptes ), Short-palped mites ( Brevipalpus lewisi )、Leptoptera serrata( Brevipalpus phoenicis )、Yellow mites( Lorryia formosa )、Fruit moss mites( Bryobia rubrioculus )、Peach Silver Mite( Aculus cornutus ), two-spotted spider mite (Tetranychus urticae Koch ).

[0083] The mollusk may be, for example, a garden grey slug (Deroceras reticulatum ), Spanish slug (Arion vulgaris )、Yellow Slug( Limax flavus), Tree Slug Limax marginatus ), Spanish invisible slug (Arion Flagellus ), Common Garden Slugs ( Arion distinctus )、Common Keeled slug( Tandonia budapestensis ), big red slugs and black slugs (Arion ater ), Large Gray Slug (Limax maximus ), Portuguese slug (Arion lusitanicus ).

[0084] The application rate of the insecticidal combination of spinetoram and group A compounds is affected by many environmental factors. The desired effect can be determined under actual use conditions.

[0085] The composition may be applied as various mixtures or combinations of spinetoram and Group A compounds, for example in a single "ready to use" form or as a combined spray mixture consisting of separate formulations of the individual active ingredients, such as in a "tank-mix" form.

[0086] In certain embodiments, the composition is applied in the form of a ready-to-use formulation comprising spinetoram and a compound of Group A. Such formulations can be obtained by combining the mixtures described in the present disclosure with agriculturally acceptable carriers, surfactants or other application-facilitating adjuvants conventionally used in formulation technology.

[0087] The composition comprising (a) spinetoram and (b) a compound of Group A can be used in any conventional form, for example in the form of a twin pack. The composition can be in the form of, for example, concentrated emulsions ("EC"), suspension concentrates ("SC"), soluble concentrates ("SL"), suspoemulsions ("SE"), oil dispersants ("OD"), water dispersible granules ("WDG" or "WG"), water-soluble granules ("SG"), and wettable powders ("WP"). Such compositions can be formulated using agriculturally acceptable carriers, surfactants, or other adjuvants conventionally used in formulation techniques to promote application and formulation techniques known in the art.

[0088] In one embodiment, the amount of active ingredient in the composition is 0.01-99.9 weight % ("wt. %"), in particular 0.1-99 weight %, more in particular 0.1-95 weight %, and even more in particular 0.1-90 weight %, based on the total weight of the composition.

[0089] Examples of suitable solid carriers include mineral earths, such as silica gel, silicates, talc, kaolin, attaclay, limestone, lime, chalk, red basalt, loess, clay, dolomite, diatomaceous earth, calcium sulfate, magnesium sulfate, magnesium oxide, sodium carbonate and bicarbonate and sodium sulfate, ground synthetic materials, fertilizers, for example ammonium sulfate, ammonium phosphate, ammonium nitrate, urea, and products of plant origin, such as grain flour, bark flour, wood flour and nut shell flour, cellulose powder and other solid carriers.

[0090] Examples of suitable liquid carriers include water, alcohols such as methanol, cyclohexanol and decanol, ethylene glycol and polypropylene glycol, N,N-dimethylformamide, dimethyl sulfoxide, N-alkylpyrrolidones, aromatic hydrocarbons such as alkylbenzenes and alkylnaphthalenes, paraffins, olive oil, castor oil, linseed oil, tung oil, sesame oil, corn oil, peanut oil, cottonseed oil, soybean oil, rapeseed oil and coconut oil, fatty acid esters, ketones such as cyclohexanone, 2-heptanone, isophorone and 4-hydroxy-4-methyl-2-pentanone, and the like.

[0091] The term "surfactant" as used herein refers to an agriculturally acceptable material that provides emulsification, stability, spreading, wetting, dispersibility or other surface modification properties. Examples of suitable surfactants include nonionic, anionic, cationic and amphoteric types of surfactants, such as lignin sulfonates, fatty acid sulfonates (e.g., dodecyl sulfonates), phosphates, such as phosphates of alcohol alkoxylates, phosphates of alkylphenol alkoxylates and phosphates of styrylphenol ethoxylates, condensates of sulfonated naphthalene and naphthalene derivatives with formaldehyde, condensates of naphthalene or naphthalenesulfonic acid with phenol and formaldehyde, alkylarylsulfonates, ethoxylated alkylphenols and arylphenols, polyalkylene glycols and ethoxylated fatty alcohols.

[0092] Other ingredients, such as wetting agents, adhesives, thickeners, binders, fertilizers or antifreeze agents may also be added to the composition comprising the combination of spinetoram and a Group A compound to improve the stability, density and viscosity of the composition.

[0093] In one embodiment, the combined amount of spinetoram and Group A compound in total in the ready-to-use formulation (composition) is 0.1-99% by weight.

[0094] In one embodiment, the combined amount of spinetoram and Group A compound in total in the ready-to-use formulation is 0.1-95% by weight.

[0095] In another embodiment, the total amount of spinetoram and group A compound in the ready-to-use formulation (composition) is 10 -4 – 99% by weight, 10 -3 - 99% by weight or 10 -2 - 99% by weight. In a specific embodiment, the total amount of spinetoram and group A compound in the ready-to-use formulation (composition) is 10 -5 –10% by weight, 10 -5 –1% by weight, 10 -5 –0.1% by weight, 10 -4 –10% by weight, 10 -4 –5% by weight, 10 -4 – 2% by weight, 10 -4 – 1% by weight, 10 -4 – 0.5% by weight or 10 -4 – 0.1% by weight.

[0096] The remaining components in the formulation are, for example, carriers and additives. In a specific embodiment, the carrier is water-based.

[0097] According to another aspect, a kit is provided, comprising (a) at least one container comprising spinetoram; (b) at least one container comprising a Group A compound selected from the group consisting of flubendiamide, pyriproxyfen, fluvalinate, and combinations thereof; and (c) instructions for applying the spinetoram and the Group A compound to pests or to a location where pest control is desired.

[0098] In one embodiment, spinetoram and the Group A compound are administered concomitantly or sequentially.

[0099] According to yet another aspect, a kit is provided, comprising (a) at least one container comprising (i) spinetoram; and (ii) a Group A compound selected from the group consisting of fluazifop, pyriproxyfen, fluvalinate, and combinations thereof; and (b) instructions for applying the spinetoram and the Group A compound to pests or to a location where pests need to be controlled.

[0100] The instructions may be in the form of a printed matter, such as an insert or a label.

[0101] A synergistic effect exists whenever the effect of the combination of active ingredients is greater than the sum of the individual effects of each ingredient. Thus, a synergistically effective amount (or effective amount of a synergistic composition or combination) is an amount that exhibits greater insecticidal activity than the sum of the insecticidal activities of the individual ingredients.

[0102] In the agricultural field, it is generally understood that the term "synergistic effect" is defined in an article entitled "Calculating synergistic and antagonistic responses of herbicide combinations" published by Colby SR in the journal Weeds, 1967, 15, pp. 20-22 (the entire text of which is incorporated herein by reference). The expected effect of a given combination of two active ingredients can be calculated as follows:

[0103]

[0104] Where E represents the expected insecticide control percentage of the combination of two pesticides at a specified dose (e.g., equal to x and y, respectively), X is the insecticide control percentage observed for spinetoram at a specified dose (equal to x), and Y is the insecticide control percentage observed for the Group A compound at a specified dose (equal to y). When the insecticide control percentage observed for the combination is greater than the expected percentage, a synergistic effect exists.

[0105] It will be appreciated that spinetoram and Group A compounds described in one particular aspect of the invention may be characterized by various features, such as weight ratios, application rates, etc., described in other aspects of the invention.

[0106] It will be appreciated that one or more features, aspects or embodiments of the present invention may be combined with one or more other features, aspects or embodiments of the present invention.

[0107] It will be appreciated that all embodiments of the invention, including those specifically described for different aspects of the invention, may be combined with any other embodiment of the invention, as appropriate. Specific implementation plan Example

[0108] Example 1 - Control of Cabbage with Flufenamide and Spinetoram Brassica oleracea L var. capitata ) and broccoli( Brassica oleracea L var. italica ) xylostella

[0109] Two trials were conducted in La Plata (Buenos Aires, Argentina) - one on cabbage and one on cauliflower, with the goal of evaluating the efficacy and interaction of foliar application of noflufenamide and spinetoram in the control of Plutella xylostella. For the preparation of the mixture, spinetoram (Delegate ® 250g ai / KgWG, Dow AgroSciences LLC) and flubendiamide (Rimon ® Supra 100 g ai / / Liter SC, Makhteshim Agan Group Company). For each treatment in Examples 1-6, a measured amount of the formulated product was diluted with water to obtain a mixture.

[0110] Applications were made using a backpack sprayer equipped with a 2.1 m wide pole with spray heads set 0.525 m apart and 8002 flat fan nozzles. In all cases, 150 l.ha was applied from 5 pm to 7 pm. -1 (L / hectare) application rate.

[0111] 10-meter long plots were used, each divided into four ridges. Application was made only to three ridges. A ridge-wide buffer zone was left between plots to minimize drift. The experimental design consisted of randomized blocks with four replications.

[0112] Evaluations at 1, 3 and 7 days after application are listed in Table B below. The number of larvae per plant (LP) is the average of 10 plants per plot. The average of 4 replicates is taken. The % control efficacy in Examples 1-6 is calculated based on the untreated control evaluated on the same day.

[0113] Table A. Description of each experiment.

[0114]

[0115] Table B: Results

[0116] Experiment 1 - Cauliflower

[0117]

[0118]

[0119] (*) In this and the following tables, the term "ai" refers to active ingredient.

[0120] Trial 2 – Kale

[0121]

[0122]

[0123] Example 2 - In sweet corn ( Zea mays var. saccharata ) Nofluanidazole and spinetoram in the control of Spodoptera frugiperda

[0124] Two trials were conducted in sweet corn crops in the Orán region (Salta, Argentina) with the objective of evaluating the efficacy of foliar application of fluazifop and spinetoram against false armyworm ( Fall Armyworm ) efficacy and interaction. For the preparation of the mixture, the products used were as described in Example 1.

[0125] Applications were made using a backpack sprayer equipped with a 2.1 m wide pole with spray heads spaced 0.525 m apart and fitted with 8002 flat fan nozzles. In all cases, 205 l.ha were applied between 6 pm and 9 pm. -1 The application amount is applied.

[0126] 10-meter long plots were used, each divided into four ridges. Application was made only to three ridges. A ridge-wide buffer zone was left between plots to minimize drift. The experimental design consisted of randomized blocks with four replications.

[0127] Evaluations at 1, 3 and 7 days after application are listed in Table B below. The number of larvae per plant (LP) is the average of 10 plants per plot (average of 4 replicates). The % efficacy was calculated in the same manner as described in Example 1.

[0128] Table A. Description of each test

[0129]

[0130] Table B: Results

[0131] Test 1

[0132] % effectiveness (based on number of larvae / plant)

[0133]

[0134]

[0135] Test 2

[0136] % effectiveness (based on number of larvae / plant)

[0137]

[0138]

[0139] Example 3 - In pepper ( Capsicum annuum Whitefly (Whitefly ( Trialeurodes vaporariorum )) Apply pyriproxyfen and spinetoram in the middle leaves for prevention and control

[0140] Evaluation of the efficacy of pyriproxyfen and spinetoram for whitefly control in pepper crops.

[0141] Two trials were conducted on pepper crops in the vegetable belt of La Plata (Province of Buenos Aires, Argentina) with the goal of evaluating the efficacy and interaction of foliar pyriproxyfen and spinetoram against whiteflies. For the preparation of the mixture, the spinetoram product used was the same as in Example 1, with pyriproxyfen (EPINGLE ® 100ga.i. / L EC, Sumitomo Chemical Co., Ltd.).

[0142] Applications were carried out using a backpack sprayer equipped with a vertical mast and a constant pressure regulator, with spray heads set 0.30 m apart from each other and equipped with 8002 flat fan nozzles. In all cases, 900-915 l.ha -1 Application was carried out at an application rate of (L / ha). 8-meter-long plots were used, each divided into four ridges (8 rows of plants). Application was carried out on two ridges, while the remaining two ridges were left as buffers. The experimental design included randomized blocks with four replications.

[0143] For example, the number of whitefly adults per leaf was evaluated 1, 3, 5, 7, 10 and 14 days after application, and the number of whitefly nymphs per leaf was evaluated 10, 14, 21 and 29 days after application. For this evaluation, 10 leaves were taken from plants located in the middle row of each plot, carefully avoiding the first and last meters of each plot. The control efficacy (%) was calculated based on the untreated control.

[0144] Description of the trials

[0145]

[0146]

[0147]

[0148]

[0149] Test 2

[0150]

[0151] (a) Spinetoram; (b) Pyriproxyfen.

[0152] Example 4 - Pepper ( Capsicum annuum ) Frankliniella occidentalis ) Pyriproxyfen and Spinetoram

[0153] This study was conducted to evaluate the efficacy of pyriproxyfen and spinetoram and their interactions against western flower thrips in pepper crops.

[0154] Two trials were conducted on pepper crops in the vegetable belt of La Plata (Province of Buenos Aires, Argentina) with the goal of evaluating the efficacy and interaction of foliar pyriproxyfen and spinetoram against western flower thrips. For the preparation of the mixture, the products used were the same as in Example 3.

[0155] Applications were carried out using a backpack sprayer equipped with a vertical mast and a constant pressure regulator, with spray heads set 0.30 m apart from each other and equipped with 8002 flat fan nozzles. In all cases, 790-937 l.ha -1 The application rate was 1.5 % of the total amount. 8 m long plots were used, each divided into four ridges (8 rows of plants). Application was made on two ridges, while the remaining two ridges were left as buffers. The experimental design consisted of randomized blocks with four replications.

[0156] For example, the number of thrips (all stages) per flower was assessed 1, 3, 5, 7, 10 and 14 days after application. For this assessment, 10 flowers were taken from plants located in the middle row of each plot, carefully avoiding the first and last meters of each plot. The control efficacy (%) was calculated based on the untreated control.

[0157] Detailed description of each test:

[0158]

[0159] Test 1

[0160]

[0161] Test 2

[0162]

[0163]

[0164] Example 5 - Pepper ( Capsicum annuum Whitefly (Whitefly ( Trialeurodes vaporariorum ) Foliar application of fluvalinate and spinetoram

[0165] Two trials were conducted on pepper crops in the vegetable belt of La Plata (Province of Buenos Aires, Argentina) with the goal of evaluating the efficacy and interaction of foliar application of fluvalinate and spinetoram for whitefly control. For the preparation of the mixture, the spinetoram product used was the same as in Example 1, and fluvalinate (Mavrik ® 240g ai / L EW, Makhteshim Agan Group Company).

[0166] Application was carried out using a backpack sprayer with a vertical mast and constant pressure regulator, with spray heads set 0.30 m apart from each other and equipped with 8002 flat fan nozzles. In all cases, 810-900 l.ha -1 The application rate was 1.5 % of the total amount. 8 m long plots were used, each divided into four ridges (8 rows of plants). Application was made on two ridges, while the remaining two ridges were left as buffers. The experimental design consisted of randomized blocks with four replications.

[0167] For example, the number of whitefly adults per leaf was evaluated 1, 3, 5, 7, 10 and 14 days after application, and the number of whitefly nymphs per leaf was evaluated 11, 15 and 21 days after application. For this evaluation, 10 leaves were taken from plants located in the middle row of each plot, carefully avoiding the first and last meters of each plot. The control efficacy (%) was calculated based on the untreated control.

[0168] Table A. Detailed description of each test

[0169]

[0170]

[0171]

[0172]

[0173]

[0174] Example 6 - Control of Frankliniella occidentalis in Capsicum annuum occidentalis) foliar application of fluvalinate and spinetoram

[0175] This study was conducted to evaluate the efficacy of fluvalinate and spinetoram and their interactions against western flower thrips in pepper crops.

[0176] The objective of two trials conducted on pepper crops in the vegetable belt of La Plata (Province of Buenos Aires, Argentina) was to evaluate the efficacy and interactions of foliar cyfluthrin and spinetoram against western flower thrips.

[0177] Applications were carried out using a backpack sprayer equipped with a vertical mast and a constant pressure regulator, with spray heads set 0.30 m apart from each other and equipped with 8002 flat fan nozzles. In all cases, 790-937 l.ha -1 The application rate was 1.5 % of the total amount. 8 m long plots were used, each divided into four ridges (8 rows of plants). Application was made on two ridges, while the remaining two ridges were left as buffers. The experimental design consisted of randomized blocks with four replications.

[0178] For example, the number of thrips (all stages) per flower was assessed 1, 3, 5, 7, 10 and 14 days after application. For this assessment, 10 flowers were taken from plants located in the middle row of each plot, carefully avoiding the first and last meters of each plot. The control efficacy (%) was calculated based on the untreated control.

[0179] Description of the trials

[0180]

[0181] Test 1

[0182]

[0183] Test 2

[0184]

[0185] Phytotoxicity

[0186] No symptoms were observed in any of the treatments of Examples 1-6.

[0187] in conclusion

[0188] The results show the excellent control efficacy of spinetoram and the combination of the co-components (bifenazuron, pyriproxyfen, fluvalinate) against pests. In addition, these combinations provide excellent control of more than one pest that tends to be present on plants at the same time.

[0189] Although the present invention has been shown and described with reference to its preferred embodiment, it will be appreciated by those skilled in the art that many substitutions, modifications and changes may be made thereto without departing from the spirit and scope of the present invention. Therefore, it is intended to encompass all such substitutions, modifications and changes that fall within the spirit and broad scope of the appended claims.

[0190] All publications, patents and patent applications mentioned in this specification are incorporated herein by reference in their entirety, as if each individual publication, patent or patent application was specifically and individually indicated to be incorporated herein by reference.

Claims

1. A method for controlling pests in growing crops, wherein the pests are selected from the group consisting of thrips, whitefly nymphs and whitefly adults, wherein the method comprises: Spinosad and pyriproxyfen are applied by foliar spraying to growing crops or growing crop sites where pest control is required, wherein the ratio of spinosad to pyriproxyfen is 0.45 to 0.8, i.e. 45:100 to 60:75, wherein the application rate of spinosad is 45 to 60 g / ha, and the application rate of pyriproxyfen is 75-100 g / ha.

2. The method according to claim 1, wherein: a. When the pest is thrips, the method provides more rapid control within 1 to 3 days after application; b. When the pest is whitefly nymphs, the method provides greater residual control lasting at least 10 to 30 days after foliar spray application.

3. The method according to claim 1, wherein: a. When the pest is thrips, the method provides greater than 60% control within 1 day after foliar spray application and greater than 70% control within 3 days after foliar spray application, b. When the pest is whitefly nymph, the method provides greater than 85% control within 10-11 days after treatment and greater than 80% control 29 to 30 days after foliar spray application, and c. When the pest is adult whiteflies, the method provides greater than 75% control within 10-14 days after treatment.

4. The method of claim 1, wherein the foliar spray application is performed by a kit for performing the foliar spray application, the kit comprising (a) at least one container comprising spinetoram; (b) at least one container comprising pyriproxyfen; and (c) instructions for foliar application of the spinetoram and the pyriproxyfen to a growing crop or a locus of a growing crop in need of pest control, wherein the ratio of spinetoram to pyriproxyfen is from 0.45 to 0.8, wherein the spinetoram is applied at a rate of 45 to 60 g / ha, and the pyriproxyfen is applied at a rate of 75-100 g / ha, wherein the pest is selected from the group consisting of thrips, whitefly nymphs, and whitefly adults.

5. The method according to claim 4, wherein the spinetoram and the pyriproxyfen are each applied concomitantly or sequentially by foliar spray application from the kit for foliar spray application comprising a container comprising spinetoram and a container comprising pyriproxyfen according to claim 4.

6. The method of claim 1, wherein the foliar spray application is performed by a kit for performing the foliar spray application, the kit comprising (a) a container comprising (i) spinetoram; and (ii) pyriproxyfen; and (b) instructions for foliar application of the spinetoram and the pyriproxyfen to a growing crop or a locus of a growing crop in need of pest control, wherein the ratio of spinetoram to pyriproxyfen is from 0.45 to 0.8, wherein the spinetoram is applied at a rate of 45 to 60 g / ha, and the pyriproxyfen is applied at a rate of 75-100 g / ha, wherein the pest is selected from the group consisting of thrips, whitefly nymphs, and whitefly adults.

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