Integrated multi-channel mass spectrometry sampling device and method

Abstract

The present invention provides an integrated multi-channel mass spectrometry sampling device and method. The integrated multi-channel mass spectrometry sampling device includes a capillary; a body having multiple through-holes extending therethrough, the multiple through-holes being arranged around the central axis of the body, with the spacing between the capillary and the central axis gradually increasing from the inlet to the outlet of the capillary; the multiple capillaries having different inner diameters and being respectively arranged within the through-holes; a heating unit and a temperature measuring unit being respectively arranged within the body; a carrier for carrying an ion source and being arranged on a circular guide rail; and a spacer being arranged on the circular guide rail so that when the ion source on the carrier corresponds to the inlet of each capillary, the spacer separates adjacent capillaries. The present invention has the advantages of strong anti-contamination ability and low detection limit.

Description

Technical Field

[0001] The present invention relates to ion injection, and in particular to an integrated multi-channel mass spectrometry injection device and method. Background Art

[0002] Traditional ESI mass spectrometers have three injection methods: diffusion injection, probe injection, and chromatographic injection. Although these injection methods have their own characteristics, they all face the problem of how to better transmit ionized gas-phase ions from the ion source to the mass detector to achieve sample analysis.

[0003] The mass detector of a conventional mass spectrometer needs to operate in a high vacuum environment. Therefore, when using an atmospheric pressure ionization (API) source or a dielectric barrier discharge (DBDI) source, an interface is required to effectively isolate the atmospheric pressure region where ions are generated and the high vacuum region where ions are detected, and to efficiently transfer the generated ions from the atmospheric pressure ion source region to the mass detector.

[0004] Because capillaries have very small internal pores, the pore size can be determined within a range of a fraction of a millimeter to several millimeters, which can effectively achieve effective isolation between the high vacuum region and the atmospheric pressure ion source region. Currently, people often use single-pore capillaries as the transmission interface for transferring ions from the ion source to the mass detector. The inlet of the single-pore capillary is exposed to the ionization region of the ion source, and the outlet is exposed to the high vacuum. Studies have shown that the pore size of the capillary is not only directly related to the vacuum degree of the MS system, but also to the detection limit and anti-contamination ability of the mass spectrometer. Single-pore capillaries have the following shortcomings:

[0005] A larger aperture corresponds to a higher ion throughput rate, but it can also easily cause contamination of the mass detector when high-concentration samples are introduced, and places higher demands on the vacuum pump. Although a smaller aperture can effectively reduce contamination when high-concentration samples are introduced, it can also result in lower signal response and poor reliability for low-concentration samples. Summary of the Invention

[0006] In order to solve the deficiencies in the above-mentioned prior art solutions, the present invention provides an integrated multi-channel mass spectrometry sampling device.

[0007] The purpose of the present invention is achieved through the following technical solutions:

[0008] An integrated multi-channel mass spectrometry sampling device, wherein the integrated multi-channel mass spectrometry sampling device comprises a capillary; the integrated multi-channel mass spectrometry sampling device further comprises:

[0009] A body having a plurality of through holes extending therethrough, the plurality of through holes being arranged around the central axis of the body, with the distance between the capillaries and the central axis gradually increasing from the inlet to the outlet of the capillaries; the plurality of capillaries having different inner diameters and being respectively arranged in the through holes;

[0010] A heating unit and a temperature measuring unit, wherein the heating unit and the temperature measuring unit are respectively arranged inside the body;

[0011] A carrier and a circular guide rail, wherein the carrier is used to carry the ion source and is arranged on the circular guide rail;

[0012] The isolating member is arranged on the circular guide rail so that when the ion sources on the carrier correspond to the inlets of the capillaries respectively, the isolating member separates adjacent capillaries.

[0013] Another object of the present invention is to provide an integrated multi-channel mass spectrometry injection method, which is achieved through the following technical solutions:

[0014] An integrated multi-channel mass spectrometry sampling method, comprising the following steps:

[0015] (A1) An ion source on a carrier ionizes an analyte, and the emitted ions enter a selected capillary; a spacer is used to isolate the capillary from other capillaries; a plurality of capillaries having different inner diameters are respectively fixed in through holes of a body, the plurality of through holes being arranged around the central axis of the body, and the distance between the capillary and the central axis gradually increases from the inlet to the outlet of the capillary;

[0016] (A2) The ions are transported through the capillary tube, and the detector then obtains the detection results of the analyte.

[0017] (A3) Determine whether the test results meet the requirements;

[0018] If the requirements are not met, proceed to step (A4);

[0019] If the requirements are met, output the test results;

[0020] (A4) Drive the carrier to rotate on the circular guide rail so that the ion source corresponds to other capillaries and enter step (A1).

[0021] Compared with the prior art, the present invention has the following beneficial effects:

[0022] 1. Strong anti-pollution ability;

[0023] When detecting high-concentration samples, the ion source selectively corresponds to the small inner diameter capillary, which improves the anti-contamination ability of the small mass spectrometer when high-concentration samples are introduced;

[0024] 2. Low detection limit;

[0025] Taking into account the detection needs of high and low concentration samples, by switching, the ion source is matched with the large-aperture capillary, achieving a lower detection limit of 1 ppb;

[0026] 3. Integrated design;

[0027] Adopting an integrated fixed structure, multiple capillaries with different inner diameters, heating units and temperature measuring units are fixed on the main body, making cleaning and replacement of components convenient and quick;

[0028] 4. High work efficiency;

[0029] The carrier for carrying the ion source is arranged on a circular guide rail and moves on the circular guide rail as required, thereby corresponding to the selected capillary and improving work efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] The disclosure of the present invention will become more easily understood with reference to the accompanying drawings. Those skilled in the art will readily appreciate that these drawings are merely used to illustrate the technical solutions of the present invention and are not intended to limit the scope of protection of the present invention.

[0031] Figure 1 is a schematic cross-sectional structural diagram of a main body according to an embodiment of the present invention;

[0032] Figure 2 is a schematic side view of a main body according to an embodiment of the present invention;

[0033] Figure 3 The figure is a flow chart of an integrated multi-channel mass spectrometry sampling method according to an embodiment of the present invention. DETAILED DESCRIPTION

[0034] Figure 1-3 The following description describes alternative embodiments of the present invention to teach those skilled in the art how to implement and reproduce the present invention. In order to explain the technical solution of the present invention, some conventional aspects have been simplified or omitted. Those skilled in the art will understand that variations or substitutions derived from these embodiments will be within the scope of the present invention. Those skilled in the art will understand that the following features can be combined in various ways to form multiple variations of the present invention. Thus, the present invention is not limited to the following alternative embodiments, but is limited only by the claims and their equivalents.

[0035] Example 1:

[0036] The integrated multi-channel mass spectrometry sample injection device of embodiment 1 of the present invention comprises:

[0037] Ontology, such as Figure 1 As shown, the body 11 has a plurality of through holes 12 extending therethrough. The plurality of through holes 12 are arranged around the central axis of the body 11. From the inlet to the outlet of the capillary tube, the distance between the capillary tube and the central axis gradually increases. The plurality of capillaries have different inner diameters and are respectively arranged in the through holes 12.

[0038] Heating unit and temperature measuring unit, such as Figure 2 As shown, the heating unit 21 and the temperature measuring unit 22 are respectively arranged inside the body 11;

[0039] A carrier and a circular guide rail, wherein the carrier is used to carry the ion source and is arranged on the circular guide rail;

[0040] The isolating member is arranged on the circular guide rail so that when the ion sources on the carrier correspond to the inlets of the capillaries respectively, the isolating member separates the adjacent capillaries.

[0041] In order to reduce the complexity of the structure, further, there is only one carrier, and when the carrier moves on the circular guide rail, it corresponds to the inlet of each capillary.

[0042] In order to facilitate the forward and backward movement of the ion source, the carrier further has a linear guide rail that allows the ion source to slide.

[0043] Figure 3 A flow chart of the integrated multi-channel mass spectrometry sampling method according to an embodiment of the present invention (ie, the working method of the integrated multi-channel mass spectrometry sampling device according to this embodiment) is schematically shown. Figure 3 As shown, the integrated multi-channel mass spectrometry injection method includes the following steps:

[0044] (A1) An ion source on a carrier ionizes an analyte, and the emitted ions enter a selected capillary; a spacer is used to isolate the capillary from other capillaries; a plurality of capillaries having different inner diameters are respectively fixed in through holes of a body, the plurality of through holes being arranged around a central axis of the body, and having gradually increasing spacing from the central axis;

[0045] (A2) The ions are transported through the capillary tube, and the detector then obtains the detection results of the analyte.

[0046] (A3) Determine whether the test results meet the requirements;

[0047] If the requirements are not met, proceed to step (A4);

[0048] If the requirements are met, output the test results;

[0049] (A4) Drive the carrier to rotate on the circular guide rail so that the ion source corresponds to other capillaries and enter step (A1).

[0050] Example 2:

[0051] An application example of the integrated multi-channel mass spectrometry injection device and its working method according to Example 1 of the present invention.

[0052] In this application example, the body is made of metal, such as aluminum. The body has four through-holes uniformly extending around the central axis of the body. Four capillaries of different inner diameters are disposed in the through-holes, with the centers of the capillary inlets being on concentric circles. The distance between each capillary and the central axis gradually increases from the capillary inlet to the capillary outlet.

[0053] There is only one carrier, and it has a linear guide rail; the ion source is a PDESI, which is arranged on the linear guide rail; the carrier is arranged on a circular guide rail, so that when the carrier moves on the circular guide rail, it corresponds to each capillary;

[0054] The body has a first blind hole and a second blind hole. A plurality of capillaries are arranged around the first blind hole. The central axis of the first blind hole is collinear with the central axis of the body.

[0055] Figure 3 A flow chart of the integrated multi-channel mass spectrometry sampling method according to an embodiment of the present invention (ie, the working method of the integrated multi-channel mass spectrometry sampling device according to this embodiment) is schematically shown. Figure 3 As shown, the integrated multi-channel mass spectrometry injection method includes the following steps:

[0056] (A1) An ion source on a carrier ionizes an analyte, and the emitted ions enter a selected capillary: a high-concentration sample corresponds to a capillary with a smaller inner diameter, and a low-concentration sample corresponds to a capillary with a smaller inner diameter; a spacer is used to isolate the capillary from other capillaries; a plurality of capillaries with different inner diameters are respectively fixed in through holes of a body, and the plurality of through holes are arranged around the central axis of the body, and the distance between the through holes and the central axis gradually increases;

[0057] (A2) The ions are transported through the capillary tube, and the detector then obtains the detection results of the analyte.

[0058] (A3) Determine whether the test results meet the requirements;

[0059] If the requirements are not met, proceed to step (A4);

[0060] If the requirements are met, output the test results;

[0061] (A4) Driving the carrier to rotate on the circular guide rail so that the ion source corresponds to other capillaries, such as a capillary with a larger inner diameter or a capillary with a smaller inner diameter, and entering step (A1).

Claims

1. An integrated multi-channel mass spectrometry sampling device, comprising a capillary; characterized in that: The integrated multi-channel mass spectrometry injection device further includes: A body having a plurality of through holes extending therethrough, the plurality of through holes being arranged around the central axis of the body, with the distance between the capillaries and the central axis gradually increasing from the inlet to the outlet of the capillaries; the plurality of capillaries having different inner diameters and being respectively arranged in the through holes; A heating unit and a temperature measuring unit, wherein the heating unit and the temperature measuring unit are respectively arranged inside the body; A carrier and a circular guide rail, wherein the carrier is used to carry the ion source and is arranged on the circular guide rail; The isolating member is arranged on the circular guide rail so that when the ion sources on the carrier correspond to the inlets of the capillaries respectively, the isolating member separates the adjacent capillaries.

2. The integrated multi-channel mass spectrometry sampling device according to claim 1, characterized in that: There is only one supporting member, and when the supporting member moves on the circular guide rail, it corresponds to the inlet of each capillary tube.

3. The integrated multi-channel mass spectrometry sampling device according to claim 1, characterized in that: The carrier has a linear guide rail that allows the ion source to slide.

4. The integrated multi-channel mass spectrometry sampling device according to claim 1, characterized in that: The ion source is PDESI.

5. The integrated multi-channel mass spectrometry sampling device according to claim 1, characterized in that: The through hole is arranged around the heating unit.

6. An integrated multi-channel mass spectrometry sampling method based on the sampling device according to any one of claims 1 to 5, the integrated multi-channel mass spectrometry sampling method comprising the following steps: (A1) An ion source on a carrier ionizes an analyte, and the emitted ions enter a selected capillary; a spacer is used to isolate the capillary from other capillaries; a plurality of capillaries having different inner diameters are respectively fixed in through holes of a body, the plurality of through holes being arranged around the central axis of the body, and the distance between the capillary and the central axis gradually increases from the inlet to the outlet of the capillary; (A2) The ions are transported through the capillary tube, and the detector then obtains the detection results of the analyte. (A3) Determine whether the test results meet the requirements; If the requirements are not met, proceed to step (A4); If the requirements are met, output the test results; (A4) Drive the carrier to rotate on the circular guide rail so that the ion source corresponds to other capillaries and enter step (A1).

7. The integrated multi-channel mass spectrometry sampling method according to claim 6, characterized in that: There is only one supporting member, and when the supporting member moves on the circular guide rail, it corresponds to the inlet of each capillary tube.

8. The integrated multi-channel mass spectrometry sampling method according to claim 6, characterized in that: The carrier has a linear guide rail that allows the ion source to slide.

9. The integrated multi-channel mass spectrometry sampling method according to claim 6, characterized in that: The ion source is PDESI.

10. The integrated multi-channel mass spectrometry sampling method according to claim 6, characterized in that: The through hole is arranged around the heating unit, and the heating unit is arranged in the main body.

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