Magnetic Cardiac Intervention Probe and Magnetic Cardiac Measurement System

Abstract

The present invention discloses a magnetocardiogram intervention probe and a magnetocardiogram measurement system. The magnetocardiogram intervention probe includes: a probe body, a catheter, a microwave waveguide, and a radiation structure. The catheter is connected to the probe body. The microwave waveguide is embedded in the catheter and extends along the length direction of the catheter. One end of the microwave waveguide is connected to a microwave system. The radiation structure is arranged in the probe body and is used to emit the microwave transmitted by the microwave waveguide in all directions. According to the magnetocardiogram intervention probe of the present invention, by connecting the catheter to the probe body, embedding the microwave waveguide in the catheter and extending it along the length direction of the catheter, connecting one end of the microwave catheter to the microwave system, and arranging the radiation structure in the probe body, the microwave transmitted by the microwave waveguide is diffused in all directions through the radiation structure, so that the magnetocardiogram intervention probe can emit microwaves after entering the human blood vessel. At the same time, the magnetocardiogram intervention probe also eliminates the coil, thereby reducing the volume of the intervention probe and improving the measurement range of the magnetocardiogram measurement system.

Description

Technical Field

[0001] The present invention relates to the technical field of medical instruments, and more particularly to a magnetocardiogram (MCG) invasive probe and an MCG measurement system. Background Art

[0002] In related technologies, in an MCG measurement system, electromagnetic waves are emitted outside the human body, and a coil is provided in the invasive probe to receive the electromagnetic wave signal. When the coil is too small, the detection accuracy will be affected. Therefore, the coil in the invasive probe cannot be too small, which makes it impossible to reduce the volume of the invasive probe, so that the invasive probe cannot reach a deeper position in the blood vessel, and the measurement range of the MCG measurement system is limited. Summary of the Invention

[0003] The present invention aims to at least solve one of the technical problems existing in the prior art. To this end, the present invention provides an MCG invasive probe, which can improve the measurement range of the MCG measurement system.

[0004] Another object of the present invention is to provide an MCG measurement system having the above-mentioned MCG invasive probe.

[0005] The MCG invasive probe according to an embodiment of the present invention includes: a probe body; a catheter connected to the probe body; a microwave waveguide embedded in the catheter and extending along the length direction of the catheter, one end of the microwave waveguide being connected to a microwave system; and a radiation structure provided in the probe body for emitting the microwave transmitted by the microwave waveguide in all directions.

[0006] The MCG invasive probe according to an embodiment of the present invention connects the catheter to the probe body, embeds the microwave waveguide in the catheter and extends it along the length direction of the catheter, connects one end of the microwave waveguide to the microwave system, and provides the radiation structure in the probe body. The radiation structure diffuses the microwave transmitted by the microwave waveguide in all directions, so that the MCG invasive probe can emit microwaves after entering the human blood vessel. At the same time, the MCG invasive probe is also provided without a coil, so that the volume of the invasive probe can be reduced, and the MCG invasive probe can enter a deeper part of the human blood vessel and emit microwaves outward, thereby improving the measurement range of the MCG measurement system and enabling doctors to obtain more useful clinical information.

[0007] According to some embodiments of the present invention, the radiation structure is formed in a conical shape, and the cross-sectional area of the radiation structure gradually increases in the direction from one end to the other end where the probe body is connected to the catheter.

[0008] According to some embodiments of the present invention, it further includes: an ablation electrode provided on the probe body.

[0009] In some embodiments of the present invention, the ablation electrode is provided at one end of the probe body away from the catheter.

[0010] In some embodiments of the present invention, an embedding groove is provided on the outer peripheral wall of the probe body, and the ablation electrode is provided in the embedding groove.

[0011] In some embodiments of the present invention, the ablation electrode is flush with the outer peripheral wall of the probe body.

[0012] According to the embodiment of the present invention, a magnetocardiogram measurement system includes: a shielding cover; a bed frame provided inside the shielding cover; a three-axis displacement stage provided inside the shielding cover; an optical fiber probe provided at the lower end of the three-axis displacement stage and above the bed frame, the optical fiber probe including a diamond NV color center, an incident optical fiber, and an outgoing optical fiber, the incident optical fiber and the outgoing optical fiber being opposite to each other, and the diamond NV color center being located between the incident optical fiber and the outgoing optical fiber; a laser system provided outside the shielding cover and connected to the incident optical fiber; a signal acquisition system provided outside the shielding cover and connected to the outgoing optical fiber; a microwave system provided outside the shielding cover for generating microwaves; the above-mentioned interventional probe located inside the shielding cover, and the microwave waveguide being connected to the microwave system; and a control system connected to the signal acquisition system, the microwave system, and the three-axis displacement stage.

[0013] According to the embodiment of the present invention, in the magnetocardiogram measurement system, by arranging the bed frame, the optical fiber probe, the above-mentioned interventional probe, and the three-axis displacement stage inside the shielding cover, and arranging the laser system, the signal acquisition system, the microwave system, and the control system outside the shielding cover, the interference of external devices and geomagnetism can be shielded, and the accuracy of the magnetocardiogram measurement system can be improved. The signal acquisition system, the optical fiber probe, and the laser system form an integrated system, and the use of optical fiber connection increases the connection stability. Among them, the microwaves emitted by the interventional probe can change the fluorescence intensity of the diamond NV color center of the optical fiber probe, so that the magnetocardiogram measurement system can construct a magnetic field map of the heart, and the abnormal activities of the heart can be found through the magnetic field map, and the position of the interventional probe can be located. Since the magnetocardiogram interventional probe can emit microwaves after entering the human blood vessel, the coil of the magnetocardiogram interventional probe can be omitted, thereby reducing the volume of the interventional probe, enabling the magnetocardiogram interventional probe to enter deeper into the human blood vessel and emit microwaves outward, further improving the measurement range of the magnetocardiogram measurement system, and enabling doctors to obtain more useful clinical information. At the same time, the interventional probe can ablate the lesions on the side wall of the blood vessel through the ablation electrode. Since the microwave power required during the detection of the magnetocardiogram measurement system is not too high, the power of the interventional probe is reduced.

[0014] According to some embodiments of the present invention, a plurality of the optical fiber probes are spaced apart.

[0015] In some embodiments of the present invention, the plurality of the optical fiber probes are arranged in an array.

[0016] According to some embodiments of the present invention, the three-axis displacement stage is connected to the inner top wall of the shielding cover.

[0017] Additional aspects and advantages of the present invention will be given in part in the following description, become apparent in part from the following description, or be learned through the practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] The above and / or additional aspects and advantages of the present invention will become apparent and be readily understood from the description of the embodiments in conjunction with the following drawings, in which:

[0019] Figure 1 is a schematic diagram of a magnetocardiogram measurement system according to an embodiment of the present invention;

[0020] Figure 2 is a schematic diagram of an optical fiber probe of a magnetocardiogram measurement system according to an embodiment of the present invention;

[0021] Figure 3 is a schematic diagram of a magnetocardiogram interventional probe according to an embodiment of the present invention;

[0022] Figure 4 is a measurement diagram of a magnetocardiogram measurement system according to an embodiment of the present invention.

[0023] REFERENCE SIGNS:

[0024] 100, magnetocardiogram measurement system;

[0025] 1, interventional probe; 11, probe body; 111, embedding groove; 12, catheter; 13, microwave waveguide; 131, microwave waveguide port; 14, radiation structure; 15, ablation electrode;

[0026] 2, shielding cover;

[0027] 3, bed frame;

[0028] 4, three-axis displacement stage;

[0029] 5, optical fiber probe; 51, diamond NV color center; 52, incident optical fiber; 53, outgoing optical fiber. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0030] Embodiments of the present invention will be described in detail below. Examples of the embodiments are shown in the accompanying drawings, where like or similar reference numerals designate like or similar elements or elements having like or similar functions throughout. The embodiments described below by referring to the accompanying drawings are exemplary only for explaining the present invention and should not be construed as limiting the present invention.

[0031] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings. They are only for facilitating the description of the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as limiting the present invention. In addition, features defined as "first" and "second" may explicitly or implicitly include one or more of such features. In the description of the present invention, unless otherwise specified, the meaning of "plurality" is two or more.

[0032] In the description of the present invention, it should be noted that, unless otherwise clearly defined and limited, the terms "mounted", "connected" and "coupled" should be understood in a broad sense. For example, it may be a fixed connection, a detachable connection or an integral connection; it may be a mechanical connection or an electrical connection; it may be a direct connection or an indirect connection through an intermediate medium, and it may be the communication inside two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0033] Reference will be made below to Figure 3 describe a magnetocardiogram interventional probe 1 according to an embodiment of the present invention.

[0034] As Figure 3 shown, a magnetocardiogram interventional probe 1 according to an embodiment of the present invention includes: a probe body 11, a catheter 12, a microwave waveguide 13 and a radiation structure 14.

[0035] As Figure 3As shown, the catheter 12 is connected to the probe body 11. The microwave waveguide 13 is embedded in the catheter 12 and extends along the length direction of the catheter 12. One end of the microwave waveguide 13 is connected to the microwave system. The radiation structure 14 is arranged in the probe body 11 and is used to emit the microwave transmitted by the microwave waveguide 13 in all directions. Specifically, the microwave waveguide port 131 of the microwave waveguide 13 is arranged in the probe body 11. The microwave emitted by the microwave system is introduced into the microwave waveguide 13. The microwave enters the probe body 11 from the microwave waveguide port 131, and the radiation structure 14 located in the probe body 11 reflects the microwave in all directions. Compared with the prior art, by arranging the microwave waveguide 13 connected to the microwave system in the interventional probe 1, the interventional probe 1 can omit the coil, thereby reducing the volume of the interventional probe 1. At the same time, since the interventional probe 1 can emit microwaves in the blood vessels of the human body, when the magnetocardiogram interventional probe 1 enters deeper into the human body, it can also emit microwaves outward, thereby increasing the measurement range of the magnetocardiogram measurement system 100 and providing more useful clinical information.

[0036] According to the magnetocardiogram interventional probe 1 of the embodiment of the present invention, by connecting the catheter 12 to the probe body 11, embedding the microwave waveguide 13 in the catheter 12 and extending along the length direction of the catheter 12, connecting one end of the microwave catheter 12 to the microwave system, arranging the radiation structure 14 in the probe body 11, and making the microwave transmitted by the microwave waveguide 13 diffuse in all directions through the radiation structure 14, the magnetocardiogram interventional probe 1 can emit microwaves after entering the blood vessels of the human body. At the same time, the magnetocardiogram interventional probe 1 also omits the coil, thereby reducing the volume of the interventional probe 1, enabling the magnetocardiogram interventional probe 1 to enter deeper into the blood vessels of the human body and emit microwaves outward, and further increasing the measurement range of the magnetocardiogram measurement system 100, enabling doctors to obtain more useful clinical information.

[0037] According to some embodiments of the present invention, as Figure 3 shown, the radiation structure 14 is formed in a conical shape, and in the direction from one end to the other end where the probe body 11 is connected to the catheter 12, the cross-sectional area of the radiation structure 14 gradually increases. Such a setting enables the radiation structure 14 to better emit the microwave transmitted by the microwave waveguide 13 in all directions.

[0038] According to some embodiments of the present invention, as Figure 3 shown, the magnetocardiogram interventional probe 1 further includes: an ablation electrode 15, and the ablation electrode 15 is arranged on the probe body 11. By arranging the ablation electrode 15 on the magnetocardiogram interventional probe 1, the interventional probe 1 can ablate and excise the diseased part on the side wall of the blood vessel after entering the blood vessel.

[0039] According to some embodiments of the present invention, as Figure 3As shown, the ablation electrode 15 is provided at one end of the probe body 11 away from the catheter 12. Such an arrangement makes the position of the ablation electrode 15 reasonable, which is beneficial for the ablation electrode 15 to ablate and remove the lesions on the side wall of the blood vessel.

[0040] According to some embodiments of the present invention, as Figure 3 shown, an embedding groove 111 is provided on the outer peripheral wall of the probe body 11, and the ablation electrode 15 is arranged in the embedding groove 111. Such an arrangement enables the ablation electrode 15 to be better connected to the probe body 11, increasing the connection stability.

[0041] According to some embodiments of the present invention, as Figure 3 shown, the ablation electrode 15 is flush with the outer peripheral wall of the probe body 11. Such an arrangement can avoid the ablation electrode 15 from damaging the blood vessel.

[0042] Next, refer to the attached Figure 1 to describe the magnetocardiogram measurement system 100 according to the embodiments of the present invention.

[0043] The magnetocardiogram measurement system 100 according to the embodiments of the present invention includes a shielding cover 2, a bed frame 3, a three-axis displacement stage 4, an optical fiber probe 5, a laser system, a signal acquisition system, a microwave system, the above-mentioned interventional probe 1, and a control system. Among them, the shielding cover 2 can shield the interference of external devices and the geomagnetic field, which can improve the accuracy of the magnetocardiogram measurement system 100.

[0044] As Figure 1 shown, the bed frame 3 is arranged inside the shielding cover 2, and the three-axis displacement stage 4 is arranged inside the shielding cover 2. Specifically, when using the magnetocardiogram measurement system 100, the patient lies flat on the bed frame 3, and the three-axis displacement stage 4 moves above the patient's heart. Such an arrangement can improve the accuracy of the magnetocardiogram measurement system 100.

[0045] As Figure 1 and Figure 2 shown, the optical fiber probe 5 is arranged at the lower end of the three-axis displacement stage 4 and above the bed frame 3. The optical fiber probe 5 includes a diamond NV color center 51, an incident optical fiber 52, and an outgoing optical fiber 53. The incident optical fiber 52 and the outgoing optical fiber 53 are opposite to each other, and the diamond NV color center 51 is located between the incident optical fiber 52 and the outgoing optical fiber 53. The laser system is arranged outside the shielding cover 2 and connected to the incident optical fiber 52. Specifically, the laser system includes a laser and a beam expander. The 532 nm wavelength laser generated by the laser is coupled and emitted through the optical fiber, and becomes a high-quality, small-divergence-angle Gaussian beam after passing through the beam expander. The Gaussian beam is reflected by the dichroic mirror and transmitted through the incident optical fiber 52 to be focused on the diamond NV color center 51, causing the diamond NV color center 51 to generate red fluorescence.

[0046] The signal acquisition system is disposed outside the shielding cover 2 and connected to the outgoing optical fiber 53. Specifically, the signal acquisition system includes a fluorescence collection structure, a photodetector, and an analog-to-digital converter. The signal acquisition system is used to collect the fluorescence signal of the diamond NV color center 51. The red fluorescence emitted by the diamond NV color center 51 passes through the outgoing optical fiber 53, passes through a dichroic mirror composed of a combination of a 650 nm long-wavelength pass and a 775 nm short-wavelength pass, filters out the 532 nm excitation light and other stray light, and finally reaches the photodetector (single-photon detector), where it is converted into an electrical signal and then converted into a digital signal by the analog-to-digital converter. Among them, the signal acquisition system, the fiber optic probe 5, and the laser system form an integrated system, and the use of fiber optic connection increases the connection stability.

[0047] The microwave system is disposed outside the shielding cover 2 and is used to generate microwaves. The invasive probe 1 is located inside the shielding cover 2, and the microwave waveguide 13 is connected to the microwave system. Specifically, the microwave system can generate microwaves of a specific frequency. The invasive probe 1 diverges the microwaves transmitted by the microwave system through the microwave waveguide 13 in all directions through the radiation structure 14. The microwaves can act on the diamond NV color center 51 and can change the fluorescence intensity of the diamond NV color center 51. When the microwave frequency matches the external magnetic field around the diamond NV color center 51, the fluorescence intensity of the diamond NV color center 51 will decrease; when the microwave frequency does not completely match the external magnetic field, the fluorescence intensity of the diamond NV color center 51 will only decrease partially.

[0048] The control system is connected to the signal acquisition system, the microwave system, and the three-axis displacement stage 4. Specifically, the control system can control the movement of the three-axis displacement stage 4, send microwave frequency data to the microwave system so that the microwave system can generate microwaves of a specified frequency, and can also read the fluorescence intensity signal from the analog-to-digital converter, and then calculate the magnetic field strength and change the microwave frequency.

[0049] The measurement process of the cardiac magnetic measurement system 100 is as follows: The invasive probe 1 is introduced into the heart through a blood vessel. The blood vessel is preliminarily imaged by subtraction angiography and the initial position of the invasive probe 1 is marked. The microwave system receives a command from the control system and generates microwaves of a specific frequency, which act on the diamond NV color center 51. The laser of the laser is coupled and emitted through the optical fiber, and becomes a Gaussian beam with high quality and small divergence angle after passing through the beam expander. The Gaussian beam is reflected by the dichroic mirror and focused on the diamond NV color center 51 through the incident optical fiber 52. The red fluorescence emitted by the NV passes through the outgoing optical fiber 53, then passes through a dichroic mirror composed of a combination of a 650 nm long-wavelength pass and a 775 nm short-wavelength pass, filters out the 532 nm excitation light and other stray light, and finally reaches the photodetector, where it is converted into an electrical signal and then converted into a digital signal and uploaded to the control system. When in a magnetic field environment, due to the action of the magnetic field, the two states of the degenerate doublet will be separated at this time (such asFigure 4 As shown, the energy difference between them is 2γB, symmetrically distributed around 2.87 GHz. Therefore, under the action of the continuous wave spectrum, two wave peaks will appear, which are symmetrically distributed relative to 2.87 GHz. So when measuring, only the distance between the two wave peaks needs to be known. Since γ is a known quantity, the magnitude of the magnetic field B can be obtained, and then a magnetocardiogram can be drawn. By analyzing the mutation signals during the measurement process, abnormal cells can be detected. During the entire measurement process, the control system analyzes the received fluorescence signals to track the position of the intrusive probe 1 in the heart (the distance between the optical fiber probe 5 and the intrusive probe 1 at this time is reflected by the intensity of the microwave received and fluorescence reflected by the diamond NV center 51 of the optical fiber probe 5), so as to achieve real-time positioning. The control system updates the position information at this time on the blood vessel image information of the digital subtraction angiography, so as to achieve the navigation and positioning function, avoiding multiple digital subtraction angiographies, and thus avoiding doctors being exposed to X-rays for a long time.

[0050] According to the magnetocardiogram measurement system 100 of the embodiment of the present invention, by arranging the bed frame 3, the optical fiber probe 5, the above-mentioned intrusive probe 1 and the three-axis displacement stage 4 in the shielding cover 2, and arranging the laser system, the signal acquisition system, the microwave system and the control system outside the shielding cover 2, the interference of external devices and the geomagnetic field can be shielded, improving the accuracy of the magnetocardiogram measurement system 100. The signal acquisition system, the optical fiber probe 5 and the laser system form an integrated system, and the use of optical fiber connection increases the connection stability. Among them, the microwave emitted by the intrusive probe 1 can change the fluorescence intensity of the diamond NV center 51 of the optical fiber probe 5, enabling the magnetocardiogram measurement system 100 to construct a magnetic field map of the heart. Through the magnetic field map, abnormal activities of the heart can be found, and the position of the intrusive probe 1 can be located. Since the magnetocardiogram intrusive probe 1 can emit microwaves after entering the human blood vessel, the coil of the magnetocardiogram intrusive probe 1 can be omitted, thereby reducing the volume of the intrusive probe 1, enabling the magnetocardiogram intrusive probe 1 to enter deeper into the human blood vessel and emit microwaves outward, and further improving the measurement range of the magnetocardiogram measurement system 100, enabling doctors to obtain more useful clinical information. At the same time, the intrusive probe 1 can ablate the lesions on the side wall of the blood vessel through the ablation electrode 15. Since the microwave power required for the magnetocardiogram measurement system 100 during detection is not too high, the power of the intrusive probe 1 is reduced.

[0051] According to some embodiments of the present invention, the optical fiber probes 5 are multiple and spaced apart. Such a setting can improve the accuracy of the magnetocardiogram measurement system 100.

[0052] According to some embodiments of the present invention, multiple optical fiber probes 5 are arranged in an array. Specifically, the multiple optical fiber probes 5 can adopt a multi-row and multi-column arrangement. For example, the multiple optical fiber probes 5 are arranged in a multi-row and multi-column manner to form a rectangular shape, and multiple optical fiber probes 5 are provided in each row and each column. Such an arrangement can further improve the accuracy of the magnetocardiogram measurement system 100.

[0053] According to some embodiments of the present invention, the three-axis displacement stage 4 is connected to the inner top wall of the shielding cover 2. Such an arrangement can improve the connection reliability of the three-axis displacement stage 4.

[0054] In the description of this specification, the description with reference to terms such as "one embodiment", "some embodiments", "illustrative embodiments", "examples", "specific examples", or "some examples" means that the specific features, structures, materials, or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0055] Although the embodiments of the present invention have been shown and described, those of ordinary skill in the art can understand that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the claims and their equivalents.

Claims

1. A magnetocardiogram measurement system, characterized in that, it includes: a shielding cover; a bed frame, and the bed frame is arranged inside the shielding cover; a three-axis displacement stage, and the three-axis displacement stage is arranged inside the shielding cover; an optical fiber probe, the optical fiber probe is arranged at the lower end of the three-axis displacement stage and above the bed frame, the optical fiber probe includes a diamond NV color center, an incident optical fiber and an outgoing optical fiber, the incident optical fiber and the outgoing optical fiber are opposite to each other, and the diamond NV color center is located between the incident optical fiber and the outgoing optical fiber; a laser system, the laser system is arranged outside the shielding cover and connected to the incident optical fiber; a signal acquisition system, the signal acquisition system is arranged outside the shielding cover and connected to the outgoing optical fiber, and the signal acquisition system is used to acquire the fluorescence signal of the diamond NV color center; a microwave system, the microwave system is arranged outside the shielding cover and used to generate microwaves; an interventional probe, the interventional probe includes a probe body, a catheter, a microwave waveguide and a radiation structure, the catheter is connected to the probe body, the microwave waveguide is embedded in the catheter and extends along the length direction of the catheter, one end of the microwave waveguide is connected to the microwave system, the radiation structure is arranged inside the probe body and used to emit the microwaves transmitted by the microwave waveguide in all directions, the interventional probe is located inside the shielding cover, and the microwave waveguide is connected to the microwave system; a control system, the control system is connected to the signal acquisition system, the microwave system and the three-axis displacement stage, and the control system determines the position of the interventional probe according to the received fluorescence signal.

2. The magnetocardiogram measurement system according to claim 1, characterized in that, the radiation structure is formed into a cone shape, and in the direction from one end of the probe body connected to the catheter to the other end, the cross-sectional area of the radiation structure gradually increases.

3. The magnetocardiogram measurement system according to claim 1, characterized in that, the interventional probe further includes: an ablation electrode, and the ablation electrode is arranged on the probe body.

4. The magnetocardiogram measurement system according to claim 3, characterized in that, the ablation electrode is arranged at the end of the probe body far from the catheter.

5. The magnetocardiogram measurement system according to claim 3, characterized in that, an embedding groove is arranged on the outer peripheral wall of the probe body, and the ablation electrode is arranged in the embedding groove.

6. The magnetocardiogram measurement system according to claim 5, characterized in that, the ablation electrode is flush with the outer peripheral wall of the probe body.

7. The magnetocardiogram measurement system according to claim 1, characterized in that, the optical fiber probes are multiple and spaced apart.

8. The magnetocardiogram measurement system according to claim 7, characterized in that, the multiple optical fiber probes are arranged in an array.

9. The magnetocardiogram measurement system according to claim 1, characterized in that, the three-axis displacement stage is connected to the inner top wall of the shielding cover.

Images