Medicinal inhalation device and blister strip for use therein

Abstract

A drug inhalation device and a blister strip used therein. A drug inhalation device is provided, comprising a housing, and a transmission mechanism, a delivery mechanism, a puncture mechanism, and an inhalation mechanism located within the housing. The housing is configured to accommodate a blister strip storing capsules; the transmission mechanism is configured to transfer the capsules to be delivered from the blister strip to a predetermined position; the delivery mechanism is configured to push the capsules to be delivered from the blister strip from the predetermined position and deliver them to the puncture mechanism; and the puncture mechanism is configured to puncture the capsules located within the puncture mechanism, allowing the drug in the capsules to enter the human body through the inhalation mechanism upon inhalation by the user. A blister strip for use in the above-described drug inhalation device is also provided.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, in particular to a drug inhalation device and a blister strip used in the drug inhalation device. Background Art

[0002] A dry powder inhaler is a formulation that contains micronized drugs or carriers in the form of capsules, blisters, or multi-dose reservoirs, delivered via a specialized inhalation device for active inhalation by the patient. As a pulmonary drug delivery dosage form, dry powder inhalers are clinically used to treat localized lung diseases such as asthma, chronic obstructive pulmonary disease, and cystic fibrosis. In recent years, pulmonary drug delivery, represented by dry powder inhalers, has become a new non-invasive approach for the delivery of peptide and protein drugs, due to the thin cell walls, large absorption area, high blood flow, low enzyme metabolic activity, and reduced first-pass effect of alveolar epithelial cells. Because dry powder inhalers do not use propellants, they can avoid the depletion of the atmospheric ozone layer caused by propellants. They are also convenient to administer, provide accurate dosage, and offer excellent efficacy. In particular, some biomacromolecules can achieve ideal bioavailability after dry powder inhalation into the lungs.

[0003] The use of dry powder inhalers requires a drug inhalation device that does not require an additional propellant or propellant. It usually delivers a fixed amount of drug into the patient's inhaled airflow, ultimately achieving pulmonary administration. Currently, common drug inhalation devices are mainly divided into three categories: (1) reservoir-type drug inhalers; (2) pre-dosed multi-meter drug inhalers, which are mostly blister-type; and (3) single-dose dry powder inhalers, which are commonly capsule-type.

[0004] Among the three types of drug inhalation devices, the reservoir-type drug inhalation device has a powder reservoir in its structure, and the drug powder is inhaled in divided doses by volume each time it is used. This device has high requirements for powder flowability, and the dry powder in the reservoir is very sensitive to infiltrated moisture, so it is necessary to add a desiccant to the device to prevent the adverse effects that external moisture may cause. For single-dose drug inhalation devices, its working principle is to place a drug capsule into the inhaler during use, and after being punctured by a needle, the capsule rotates with the inhaled air flow, simultaneously releasing the drug particles contained therein. This type of device has a simple structure, is easy to use, and has low inherent resistance. However, the disadvantage is that the drug must be loaded each time during use, and the moisture-proof performance is poor, and the drug powder is easily damp and solidified, which affects the output.

[0005] Compared to the two aforementioned inhalation devices, pre-dosed multi-dose inhalers offer distinct advantages. These devices typically utilize a blister-type design. These devices seal drug powder within blister packs on a disc-shaped conveyor belt made of aluminum foil, which is then wrapped around a rotating disk. Because each dosage unit is individually packaged and sealed, the drug is protected from environmental factors such as temperature and humidity, ensuring precise control of the drug dosage.

[0006] However, in conventional pre-dose multi-metered drug inhalation devices, a dedicated blister is required, and the structure of the dedicated blister is relatively complex and the cost is high.

[0007] It can be seen that there is a need in the art for improved medicinal inhalation devices. Summary of the Invention

[0008] In view of the problems in the prior art, embodiments of the present invention provide an improved medicinal inhalation device, which can at least partially alleviate or eliminate one or more of the defects in the prior art.

[0009] In one aspect of the present invention, a drug inhalation device is provided, comprising a housing, and a transmission mechanism, a delivery mechanism, a puncture mechanism, and an inhalation mechanism located within the housing. The housing is configured to accommodate a blister strip storing capsules; the transmission mechanism is configured to transfer the capsules to be delivered from the blister strip to a predetermined location; the delivery mechanism is configured to push the capsules to be delivered from the blister strip from the predetermined location and deliver them to the puncture mechanism; and the puncture mechanism is configured to puncture the capsule located within the puncture mechanism, allowing the drug in the capsule to enter the human body through the inhalation mechanism upon inhalation by the user.

[0010] According to an exemplary embodiment of the present invention, the delivery mechanism includes a pushing portion configured to push the capsule in the blister portion located at the predetermined position toward the puncture mechanism.

[0011] According to an exemplary embodiment of the present invention, the propulsion portion includes a push rod and a push rod spring, the push rod being configured to propel the capsule located at the predetermined position in response to being pressed, and the push rod spring being configured to reset the push rod in response to the pressing being released.

[0012] According to an exemplary embodiment of the present invention, the delivery mechanism includes a rotating claw configured to puncture the blister strip in response to being rotated, and delivers the capsule to be delivered to the puncturing mechanism by the rotation.

[0013] According to an exemplary embodiment of the present invention, the transmission mechanism includes a driving gear, a first driven gear and a blister strip transfer wheel, the driving gear is configured to drive the first driven gear to rotate, and the blister strip transfer wheel is configured to transmit the blister strip under the drive of the first driven gear.

[0014] According to an exemplary embodiment of the present invention, the transmission mechanism further includes a first ratchet mechanism, and the first ratchet mechanism is configured to drive the driving gear to rotate.

[0015] According to an exemplary embodiment of the present invention, the above-mentioned medicinal inhalation device further comprises a protective cover, wherein the protective cover is configured to cover the inhalation mechanism in a closed state and actuate the first ratchet mechanism in an open state.

[0016] According to an exemplary embodiment of the present invention, the transmission mechanism further includes a second driven gear and a blister strip recovery wheel. The driving gear is further configured to drive the second driven gear to rotate, and the blister strip recovery wheel is configured to recover the portion of the blister strip after drug delivery under the drive of the second driven gear.

[0017] According to an exemplary embodiment of the present invention, the puncture mechanism includes a puncture chamber, an actuating knob, a paddle, a hollow shaft, a rotating chamber, a knob spring, a sliding cam, and a puncture needle. The puncture chamber is connected to the transmission mechanism and is configured to receive a capsule from the predetermined position; the actuating knob is configured to deliver the capsule from the side of the puncture chamber close to the propulsion mechanism to the side close to the suction mechanism in response to rotation, and deliver the capsule located in the puncture chamber to the rotating chamber via the paddle and the hollow shaft in response to pressing. The knob spring is configured to reset the actuating knob in response to the release of the pressing force. The sliding cam is located in the rotating chamber and is configured to drive the puncture needle to puncture the capsule located in the puncture chamber.

[0018] According to an exemplary embodiment of the present invention, the actuating knob is equipped with a second ratchet mechanism configured to ensure a unidirectional rotation of the actuating knob.

[0019] According to an exemplary embodiment of the present invention, the suction mechanism includes a suction nozzle and a pin, and the suction nozzle is connected to the puncture mechanism through the pin.

[0020] According to an exemplary embodiment of the present invention, the suction nozzle is provided with a mesh portion.

[0021] In another aspect of the present invention, a blister strip for use in any of the above-mentioned medicinal inhalation devices is provided, the blister strip comprising at least one blister portion and a soft portion configured to carry the at least one blister portion, each of the blister portions containing a capsule of a single inhaled dose of medicine, the blister strip being stored inside a housing.

[0022] According to an exemplary embodiment of the present invention, the blister strip is used in a medicinal inhalation device using a rotating claw, and the slope of the side of each blister portion contacting the rotating claw is smaller than the slope of the opposite side of the blister portion.

[0023] According to an exemplary embodiment of the present invention, the specifications of the capsules in the blister strip include No. 5, No. 4, No. 3, No. 2, No. 1, No. 0, No. 00, and No. 000.

[0024] Compared to the prior art, the drug inhalation device provided by the embodiments of the present invention can use capsule filling technology to pre-measure the dosage of the drug in the capsule, and use a certain number of capsules (for example, 30 or 60) to form a complete drug storage structure, so that multiple doses can be accurately delivered sequentially through a single drug storage structure. Combining multiple capsules in a single drug storage structure enables the use of relatively inexpensive and mature capsule quantitative filling technology, thereby ensuring a verified dosage of the drug and making the drug unaffected by environmental factors such as temperature and humidity.

[0025] Furthermore, the medicinal inhalation device provided by the embodiments of the present invention is compatible with mature standard manufacturing processes to fill capsules and package them in blisters. Compared with conventional blister-type medicinal inhalation devices, the medicinal inhalation device provided by the embodiments of the present invention has fewer restrictions on the amount of drug that can be delivered, and the design of the blister strip is also simpler.

[0026] It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not intended to restrict the invention in any way. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] These and other aspects of the present invention will now be described in more detail, with reference to the accompanying drawings showing embodiments of the invention, wherein the drawings are not necessarily to scale, emphasis instead being placed upon illustrating the principles of the invention.

[0028] In the attached figure:

[0029] Figure 1 schematically illustrates an external view of a medicinal inhalation device according to an exemplary embodiment of the present invention;

[0030] Figure 2 schematically illustrates a cross-sectional view of the interior of a medicinal inhalation device according to an exemplary embodiment of the present invention, in which in particular the storage, delivery and retrieval of a blister strip are illustrated;

[0031] Figure 3 Schematically illustrates an internal cross-sectional view of a medicinal inhalation device according to an exemplary embodiment of the present invention, wherein a transmission mechanism, a delivery mechanism, and a propulsion unit are illustrated in detail;

[0032] Figure 4 Schematically illustrates a cross-sectional view of a medicinal inhalation device according to an exemplary embodiment of the present invention, viewed from below, wherein the puncture mechanism, the delivery mechanism, and the propulsion unit are illustrated in detail;

[0033] Figure 5 A more detailed diagram shows Figure 4 The puncture mechanism shown;

[0034] Figure 6 A more detailed diagram shows Figure 4 and Figure 5 The sliding cam shown in ;

[0035] Figure 7 schematically illustrates an inhalation mechanism of a medicinal inhalation device according to an exemplary embodiment of the present invention;

[0036] Figure 8 schematically illustrates a delivery mechanism of a medicinal inhalation device according to another exemplary embodiment of the present invention;

[0037] Figure 9 Schematically illustrates an actuating knob and a paddle in a puncture mechanism of a medicinal inhalation device according to an exemplary embodiment of the present invention;

[0038] Figure 10 Schematically illustrates the working mode of the paddle and the hollow shaft of the medicinal inhalation device according to an exemplary embodiment of the present invention;

[0039] Figure 11 Schematically illustrates a rotating chamber of a medicinal inhalation device according to an exemplary embodiment of the present invention;

[0040] Figure 12 schematically illustrates a ratchet mechanism according to an exemplary embodiment of the present invention; and

[0041] Figure 13 A mesh portion of a suction mechanism according to an exemplary embodiment of the present invention is schematically illustrated.

[0042] Like reference numerals are used throughout the drawings to refer to like parts.

[0043] The above drawings illustrate some embodiments of the present invention, which will be described in more detail below. These drawings and the accompanying description are not intended to limit the scope of the present invention in any way, but rather to illustrate the concept of the present invention to those skilled in the art by reference to specific embodiments. DETAILED DESCRIPTION

[0044] To make the purpose, technical solutions, and advantages of the embodiments of the present invention more clear, the technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the described embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0045] The embodiment of the present invention provides a drug inhalation device, such as Figure 1As shown, from the outside, the drug inhalation device comprises a housing 1, a rotatable protective cover 2, a push rod 3, a push knob 4, a mouthpiece 5, and a rotating chamber 6. The protective cover 2 can be rotatably closed and opened. When closed, the protective cover 2 covers the mouthpiece 5 to prevent contamination. When the user needs to inhale the drug, the protective cover 2 is opened to expose the mouthpiece 5. Optionally, the mouthpiece 5 can be folded in the protective cover 2 to further ensure the cleanliness of the mouthpiece 5.

[0046] like Figure 1 The medicinal inhalation device shown is for use with a blister strip carrying capsules. Figure 2 The storage, delivery and retrieval of a blister strip inside a medicinal inhalation device are schematically illustrated. Figure 2 As shown, a blister strip 19 containing multiple capsules is rolled into a disk and housed in a housing 1. The medication in the capsules is delivered to the user via a transmission mechanism, a delivery mechanism, a puncture mechanism, and an inhalation mechanism within the housing 1. Specifically, the transmission mechanism is configured to transport the capsules to be delivered from the blister strip 19 to a predetermined location. The delivery mechanism is configured to push the capsules to be delivered from the blister strip 19 from the predetermined location and deliver them to the puncture mechanism. The puncture mechanism is configured to puncture the capsules within the puncture mechanism, allowing the medication in the capsules to enter the human body through the inhalation mechanism when the user inhales. The user inhales the medication through the inhalation mechanism.

[0047] Specifically, Figure 3 Schematically illustrates a transmission mechanism according to an exemplary embodiment of the present invention. Figure 2 and Figure 3 As shown, the transmission mechanism includes a driving gear 15, a first driven gear 9 and a blister strip transfer wheel 17. The driving gear 15 is configured to drive the first driven gear 9 to rotate, and the first driven gear 9 in turn drives the blister strip transfer wheel 17 to rotate, thereby transferring the blister strip 19 so as to transfer the capsule to be delivered to a predetermined position. Figure 2 In the illustrated embodiment, the predetermined position is aligned with the pushing direction of the push rod 3. In a specific implementation, the specific parameters of each gear can be set according to the adjacent distance between blisters on the blister strip, and the corresponding gear model can be selected to achieve precise feeding of the capsules in the blisters, thereby transferring the capsules to be delivered to a specific position.

[0048] Alternatively, as Figure 3 As shown, the transmission mechanism may further include a first ratchet mechanism 7, which may drive the driving gear 15 to rotate so as to actuate the driving gear 15. Further optionally, the driving gear 15 may be connected to the protective cover 2 via the first ratchet mechanism 7. Specifically, Figure 12The diagram schematically illustrates the structure of the first ratchet mechanism 7, which comprises two interacting ratchets. The first ratchet 38 is keyed to the protective cover 2 and rotates as the protective cover 2 rotates. The second ratchet 37 cooperates with the first ratchet 38. When the protective cover 2 is opened, the first ratchet 38 drives the second ratchet 37 to rotate, which in turn drives the driving gear 15, thereby driving the transmission mechanism. When the protective cover 2 is closed, the first ratchet 38 changes its rotational direction, preventing it from driving the second ratchet 37. Therefore, the transmission mechanism does not operate when the protective cover 2 is closed, preventing a used blister strip from returning to its pre-use position. In this embodiment, the protective cover 2 not only provides protection but also activates the transmission mechanism, eliminating the need for dedicated components for activating the transmission mechanism. This simplifies the structure of the drug inhalation device and reduces its cost. Furthermore, the use of a ratchet drive between the protective cover 2 and the driving gear 15 prevents the blister strip from returning to its original position after use when the protective cover is closed, ensuring consistent use.

[0049] Certainly, those skilled in the art will appreciate that the method of driving the driving gear by the protective cover and the ratchet mechanism is only an embodiment. Under the teachings of the present invention, those skilled in the art can think of various other methods of directly driving the driving gear to transmit the blister strip.

[0050] In actual use, if the length of the blister strip 19 is long, it is necessary to recover the portion of the blister strip 19 after the capsule is delivered in the housing 1 to prevent the portion from affecting the transmission of the rest of the blister strip 19. In view of this, optionally, as Figure 2 and Figure 3 As shown, the transmission mechanism may further include a second driven gear 11 and a blister strip recovery wheel 18. The driving gear 15 is further configured to drive the second driven gear 11 to rotate, and the second driven gear 11 in turn drives the blister strip recovery wheel 18 to recover the portion of the blister strip 19 after the drug has been delivered. This portion is wound around the blister strip recovery wheel 18 to avoid affecting the transmission of the remaining portion of the blister strip 19.

[0051] Figure 2 and Figure 3 The delivery mechanism of the drug inhalation device according to an exemplary embodiment of the present invention is also schematically illustrated. Specifically, the delivery mechanism includes a propulsion unit configured to propel the capsule in the blister unit at a predetermined position to the puncture mechanism. Figure 2 and Figure 3 As shown, the pusher unit includes a push rod 3 and push rod springs 13 and 14. After the blister strip 19 is transferred to a predetermined position by the transmission mechanism, the push rod 3 can be manually pushed to advance the capsules in the blisters into the piercing mechanism. When the push rod 3 is released, the push rod springs 13 and 14 return the push rod 3 to its original position.

[0052] Optionally, the side surface of the push rod 3 close to the blister portion may have a concave shape to better match and contact the convex outer surface of the blister portion, thereby achieving effective advancement of the capsule.

[0053] Figure 4 and Figure 5 The puncture mechanism of the medicinal inhalation device according to an exemplary embodiment of the present invention is schematically illustrated. Figure 4 and Figure 5 As shown, the puncture mechanism includes a puncture chamber 21, an actuation knob 4, a paddle 24 (specifically, as shown in FIG. Figure 9 As shown), the rotating cavity 6 (specifically, as Figure 11 As shown), knob spring 20, sliding cam 8 and puncture needle 23. After the capsule is pushed into the puncture cavity 21 by the delivery mechanism, the capsule can be delivered from the side of the puncture cavity 21 close to the push rod 3 to the side close to the suction nozzle 5 by rotating the actuating knob 4. The actuating knob 4 pushes the capsule from the puncture cavity 21 to the rotating cavity 6 through the lower end of the paddle 24 through the squeezing action of the paddle 24 on the actuating knob and the hollow shaft 25 connected to the housing 1. After the actuating knob 4 is rotated to deliver the capsule to the side of the puncture cavity 21 close to the suction nozzle 5, the actuating knob 4 is pressed so that the capsule is pushed out of the puncture cavity 21 into the rotating cavity 6 due to the action of the paddle 24 and the hollow shaft 25 located on the housing 1 (specifically, as shown). Figure 10 As shown in FIG, the paddle 24 will move to both sides, thereby pushing the capsule out of the puncture cavity 21 into the rotating cavity 6, and the rotating cavity 6 is connected to the suction nozzle 5. When the actuating knob 4 is released, the actuating knob 4 will bounce upward to its original position due to the action of the knob spring 20.

[0054] Optionally, the actuating knob 4 may be equipped with a second ratchet mechanism to ensure that the actuating knob 4 can only be rotated in one direction, thereby preventing erroneous operation during drug inhalation.

[0055] Furthermore, the sliding cam 8 is located in the rotating chamber 6. When the puncture chamber 21 rotates in the rotating chamber 6, it drives the puncture spring 22 and the puncture needle 23 to rotate together in the rotating chamber 6, so that the sliding cams 8 arranged on the upper and lower sides of the inner wall of the rotating chamber 6 drive the puncture needle 23 to move up and down, thereby puncturing the capsule located in the puncture chamber 21.

[0056] Specifically, Figure 6 The slide cam 8 is shown in more detail. Figure 6 As shown, the height change of the puncture needle 23 in the rotating chamber 6 can be controlled by changing the height of the curved surface, so that when the puncture chamber 21 rotates under the drive of the actuating knob 4, the capsule will be punctured during the up and down movement of the puncture needle 23 and simultaneously delivered to the side of the rotating chamber 6 close to the suction nozzle 5.

[0057] Figure 7Schematically illustrates an inhalation mechanism of a medicinal inhalation device according to an exemplary embodiment of the present invention. Figure 7 As shown, the suction nozzle 5 is connected to the rotating chamber 6 of the puncture mechanism via a pin 26 .

[0058] Alternatively, as Figure 13 The bottom of the nozzle 5 is exemplarily shown to be provided with a mesh portion to restrict the movement of the capsule. When the medicine is inhaled, the capsule rotates in the rotating chamber so that the medicine can be fully released, and the mesh portion restricts the movement of the capsule, ensuring that the medicine can be inhaled while making the capsule rotate smoothly.

[0059] Figure 8 Schematically illustrates a delivery mechanism of a medicinal inhalation device according to another exemplary embodiment of the present invention. Figure 8 As shown, capsules 35 containing medicine are filled in a blister strip 34 having a special structure and being easy to tear. When the blister strip 34 moves to a predetermined position, the rotating claw 33 can puncture the blister strip 34 during its rotation and further deliver the capsules 35 to the side of the rotating chamber 32 near the suction nozzle 31, thereby completing the delivery of the capsules containing medicine.

[0060] exist Figure 8 In the illustrated embodiment, the push rod is omitted, thereby further simplifying the structure of the drug inhalation device and achieving miniaturization and lightweighting of the drug inhalation device.

[0061] Specifically, in Figure 8 The delivery mechanism shown is used in conjunction with a blister strip, such as Figure 8 As shown, the slope of the side of each blister portion in contact with the rotating claw 33 is smaller than that of the opposite side of the blister portion, so that the capsules in the blister portions of the blister strip 34 are more easily taken out by the rotating claw 33 .

[0062] When operating a drug inhalation device according to an embodiment of the present invention, a user inhales medication by opening the protective cover, pressing the push rod, and rotating the push knob. To prevent malfunction of the drug inhalation device, the blister strip will not be delivered forward if the user opens and closes the protective cover multiple times. The blister strip will only be delivered forward if the user opens the protective cover, presses the push rod, and then opens the protective cover again.

[0063] In another aspect, embodiments of the present invention provide a blister strip for use in any of the aforementioned drug inhalation devices. The blister strip includes at least one blister portion and a flexible portion configured to support the at least one blister portion. Each blister portion contains a capsule containing a single inhaled dose of medication. Specifically, the blister strip includes a blister portion and a flexible portion, for example, one side of which is made of PVC-type material and the other side of which is made of aluminum foil. Furthermore, embodiments of the present invention provide a blister strip that can adaptably accommodate a variety of capsule sizes, including size 5, size 4, size 3, size 2, size 1, size 0, size 00, size 000, and so on. The purpose of the blister strip is to store the capsules in an isolated environment, maintain a certain humidity, protect them from light and other environmental factors that could potentially adversely affect the dosage form, and organize the capsules before they are delivered to the rotating chamber. For each dose to be delivered, the capsules to be used are moved into the rotating chamber using a prepared blister strip for the user to use. Once the user has emptied the dosage form from the capsule, the inhaler nozzle can be opened to discard the empty capsule. Compared to the prior art, the drug inhalation device and blister strip used therein provided by the present invention can utilize capsule filling technology to pre-measure the dosage of the drug in the capsule, and use a certain number of capsules (e.g., 30 or 60) to form a complete drug storage structure, thereby accurately delivering multiple doses sequentially through a single drug storage structure. Combining multiple capsules in a single drug storage structure enables the use of relatively inexpensive and mature capsule quantitative filling technology, thereby ensuring a verified dosage of the drug and protecting the drug from environmental factors such as temperature and humidity.

[0064] Furthermore, the medicinal inhalation device provided by the embodiments of the present invention is compatible with mature standard manufacturing processes to fill capsules and package them in blisters. Compared with conventional blister-type medicinal inhalation devices, the medicinal inhalation device provided by the embodiments of the present invention has fewer restrictions on the amount of drug that can be delivered, and the design of the blister strip is also simpler.

[0065] As will be appreciated by those skilled in the art, the above-described embodiments are only a portion of the total number of embodiments of the present invention, and the present invention is in no way limited to the exemplary embodiments described above. On the contrary, many modifications and variations are possible within the scope of the appended claims. For example, other components may be added to or removed from the described apparatus. Other embodiments are possible within the scope of the present invention. Furthermore, in the claims, the word "comprising" does not exclude other elements or steps. The mere fact that certain measures are recited in mutually different dependent claims does not indicate that a combination of these measures cannot be used to advantage.

Claims

1. A drug inhalation device, characterized in that: The invention comprises a housing, and a transmission mechanism, a delivery mechanism, a puncture mechanism and an inhalation mechanism located in the housing, wherein The housing is configured to house a blister strip of storage capsules; The transmission mechanism is configured to transport the capsule to be delivered in the blister strip to a predetermined position; The delivery mechanism is configured to push the capsule to be delivered in the blister strip out of the blister strip from the predetermined position and deliver it to the piercing mechanism; The puncture mechanism is configured to puncture a capsule located within the puncture mechanism, so that the medicine in the capsule can enter the human body through the inhalation mechanism under inhalation by the user; wherein the puncture mechanism comprises a puncture chamber, an actuating knob, a paddle, a hollow shaft, a rotating chamber, a knob spring, a sliding cam, and a puncture needle, wherein the puncture chamber is connected to the transmission mechanism and is configured to receive the capsule from the predetermined position; The actuating knob is configured to deliver the capsule from the side of the puncture cavity closer to the propulsion mechanism to the side closer to the inhalation mechanism in response to rotation, and deliver the capsule located in the puncture cavity toward the rotating cavity via the paddle and the hollow shaft in response to pressing; when the puncture cavity rotates in the rotating cavity, the puncture spring and the puncture needle are driven to rotate together in the rotating cavity, so that the sliding cams provided on the upper and lower sides of the inner wall of the rotating cavity drive the puncture needle to move up and down, thereby puncturing the capsule located in the puncture cavity; The knob spring is configured to reset the actuation knob in response to removal of the pressing force, The sliding cam is located in the rotating cavity and is configured to drive the puncture needle to puncture the capsule located in the puncture cavity.

2. The drug inhalation device according to claim 1, characterized in that The delivery mechanism includes a pushing portion configured to push the capsule in the blister portion at the predetermined position toward the puncturing mechanism.

3. The drug inhalation device according to claim 2, characterized in that The pushing portion includes a push rod and a push rod spring. The push rod is configured to push the capsule located at the predetermined position in response to being pressed. The push rod spring is configured to reset the push rod in response to the pressing being released.

4. The drug inhalation device according to claim 1, characterized in that The delivery mechanism includes a rotating claw configured to puncture the blister strip in response to being rotated, and delivers the capsule to be delivered to the puncturing mechanism by the rotation.

5. The drug inhalation device according to claim 1, characterized in that The transmission mechanism includes a driving gear, a first driven gear and a blister strip transfer wheel. The driving gear is configured to drive the first driven gear to rotate, and the blister strip transfer wheel is configured to transfer the blister strip under the drive of the first driven gear.

6. The drug inhalation device according to claim 5, characterized in that The transmission mechanism further includes a first ratchet mechanism, which is configured to drive the driving gear to rotate.

7. The medicinal inhalation device according to claim 6, characterized in that Also included is a protective cover configured to cover the suction mechanism in a closed state and actuate the first ratchet mechanism in an open state.

8. The medicinal inhalation device according to claim 5, characterized in that: The transmission mechanism further includes a second driven gear and a blister strip recovery wheel. The driving gear is further configured to drive the second driven gear to rotate, and the blister strip recovery wheel is configured to recover the portion of the blister strip after drug delivery under the drive of the second driven gear.

9. The medicinal inhalation device according to claim 1, characterized in that The actuation knob is equipped with a second ratchet mechanism configured to ensure unidirectional rotation of the actuation knob.

10. The medicinal inhalation device according to claim 1, characterized in that The suction mechanism comprises a suction nozzle and a pin, and the suction nozzle is connected to the puncture mechanism through the pin.

11. The medicinal inhalation device according to claim 10, characterized in that: The suction nozzle is provided with a grid portion.

12. A blister strip for use in a medicinal inhalation device according to any one of claims 1 to 11, characterized in that: The blister strip comprises at least one blister portion and a soft portion configured to carry the at least one blister portion, each of the blister portions containing a capsule of a single inhalation dose of medicine, and the blister strip is stored inside the housing.

13. The blister strip according to claim 12, wherein The blister strip is used in the medicinal inhalation device according to claim 4, and the slope of the side of each blister portion contacting the rotating claw is smaller than that of the opposite side of the blister portion.

14. The blister strip of claim 12, wherein The specifications of the capsules in the blister strip include No. 5, No. 4, No. 3, No. 2, No. 1, No. 0, No. 00, and No. 000.

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