Chromosome Scanning Device

Abstract

The present invention relates to a chromosome scanning device, which comprises: a microscope assembly; a slide basket with a card slot for accommodating slides inside; and a conveying mechanism, including a first driving assembly, a second driving assembly, a scanning platform and a dragging assembly; the first driving assembly is connected to the slide basket to drive the slide basket to move up and down; the second driving assembly is connected to the scanning platform to drive the scanning platform to move relative to the microscope assembly; the dragging assembly is used to drag the slide from the slide basket to the scanning platform, and the microscope assembly is used to scan the slide on the scanning platform. By the mutual cooperation of the conveying mechanism and the slide basket, the automatic and stable transfer of the slide between the slide basket and the scanning platform can be realized, without manually loading the slide on the scanning platform, which not only improves the sample processing efficiency, but also can effectively ensure the safety of the transfer and prevent the situation of slide damage or specimen contamination.

Description

Technical Field

[0001] The present invention relates to the technical field of biological sample detection equipment, and particularly to a chromosome scanning device. Background Art

[0002] With the continuous improvement of the level of biological sample inspection, chromosome scanning devices are increasingly used in the chromosome inspection of samples. Currently, a conventional chromosome scanning device includes a scanning platform and a detection component suspended above the scanning platform. After placing a slide carrying a sample on the scanning platform, the sample can be observed and analyzed through the detection component.

[0003] However, the current chromosome scanning device has a low degree of automation. For example, during the sample processing, an operator needs to manually pick up and place the slide on the scanning platform, and after the analysis is completed, the operator also needs to manually pick up the slide from the scanning platform. In this way, both the placement and removal of the slide require manual operations, resulting in a low degree of automation in sample processing and further leading to a low sample processing efficiency. Summary of the Invention

[0004] Based on this, it is necessary to provide a fully automated chromosome scanning device with a relatively high sample processing efficiency.

[0005] A chromosome scanning device includes:

[0006] A microscope assembly;

[0007] A slide basket, with a card slot for accommodating slides inside; and

[0008] A conveying mechanism, including a first driving component, a second driving component, a scanning platform, and a dragging component; the first driving component is connected to the slide basket to drive the slide basket to move up and down; the second driving component is connected to the scanning platform to drive the scanning platform to move relative to the microscope assembly; the dragging component is used to drag the slide from the slide basket to the scanning platform, and the microscope assembly is used to scan the slide on the scanning platform.

[0009] In the above chromosome scanning device, through the mutual cooperation of the conveying mechanism and the slide basket, the automatic and stable transfer of the slide between the slide basket and the scanning platform can be realized, without the need for manual loading of the slide on the scanning platform, which not only improves the sample processing efficiency but also effectively ensures the safety of the transfer and prevents the slide from being damaged or the sample from being contaminated. Description of the Drawings

[0010] Figure 1 It is a schematic structural diagram of a chromosome scanning device according to an embodiment of the present invention;

[0011] Figure 2 For Figure 1 The structural schematic diagrams of three perspectives of the slide holder in the chromosome scanning device shown;

[0012] Figure 3 For Figure 2 The structural explosion diagrams of two perspectives of the slide holder shown in;

[0013] Figure 4 For Figure 1 The rear view of the cartridge mechanism, the front view, and the schematic diagram of the state where the limiting member is engaged with the slide holder in the chromosome scanning device shown;

[0014] Figure 5 For Figure 4 The structural explosion diagram of the cartridge mechanism shown;

[0015] Figure 6 For Figure 1 The structural schematic diagram of the first driving component in the conveying mechanism shown;

[0016] Figure 7 For Figure 1 The assembly schematic diagram when the second driving component and the dragging component in the conveying mechanism are assembled together and the explosion diagram when they are separated;

[0017] Figure 8 For Figure 1 The structural schematic diagram of the oil dropping mechanism in the chromosome scanning device shown. Specific embodiments

[0018] Combined with Figures 1 to 7 Shown, the chromosome scanning device 10 of an embodiment of the present invention includes a detection component 11, a cartridge mechanism 21, a conveying mechanism 31, and an oil dropping mechanism 41. Among them, the cartridge mechanism 21 is used to carry a relatively large number of slides carrying biological specimens, the conveying mechanism 31 can convey the slides of the cartridge mechanism 21 into the field of view of the detection component 11, and the specimen placed in the field of view can be detected through the detection component 11. The oil dropping mechanism 41 is used to drop lens oil onto the slide located in the field of view of the detection component 11 to enable the detection component 11 to present better imaging quality. The cartridge mechanism 21 includes a slide holder 22 and a slide basket 26. The slide holder 22 is used to carry the slides, and the slide holder 22 is installed in the slide basket 26. Specifically, by placing the slides on the slide holder 22, the situation where the operator directly contacts the slides and causes the specimen to be contaminated can be avoided, and multiple slides can be placed on the slide holder 22, enabling the detection component 11 to detect multiple specimens. Multiple slide holders 22 can be installed in the slide basket 26, thereby realizing the loading and transportation of multiple slide holders 22.

[0019] Combined with Figure 2 And Figure 3As shown, specifically in this embodiment, the slide holder 22 includes a main body 23 and a clamping assembly 24. The main body 23 includes a surrounding edge 231 and a supporting portion 232 connected to the surrounding edge 231. The supporting portion 232 is used to support the slide, and the clamping assembly 24 is disposed on the surrounding edge 231. The clamping assembly 24 includes a first clamping structure 24a and a second clamping structure 24b. Among them, a pick-and-place operation position 233 is formed on the surrounding edge 231. The pick-and-place operation position 233 and the first clamping structure 24a are oppositely arranged on both sides of the supporting portion 232. The second clamping structure 24b and the pick-and-place operation position 233 are on the same side of the supporting portion 232, and the second clamping structure 24b is provided on both sides of the pick-and-place operation position 233. The slide can be picked up and placed on the supporting portion 232 via the pick-and-place operation position 233, and the first clamping structure 24a and the second clamping structure 24b cooperate to clamp the slide along the longitudinal direction of the slide. By arranging the pick-and-place operation position 233 between the two second clamping structures 24b and making the pick-and-place operation position 233 opposite to the first clamping structure 24a, the two second clamping structures 24b and the first clamping structure 24a are distributed in a triangular shape, so as to realize stable clamping of the slide. At the same time, through the pick-and-place operation position 233 between the two second clamping structures 24b, a larger operation space can be provided for the operator to pick up and place the slide on the supporting portion 232, improving the convenience of the slide pick-and-place operation.

[0020] Further, the pick-and-place operation position 233 extends in the direction towards the first clamping structure 24a and extends beyond the second clamping structure 24b. In this way, after the slide is placed on the supporting portion 232, a local area on the slide corresponds to the pick-and-place operation position 233, so that the operator can have a larger contact area with the slide to ensure stable contact when picking up and placing the slide and provide a relatively stable clamping force to prevent the slide from falling. Specifically, the pick-and-place operation position 233 is a groove-like structure extending from the surrounding edge 231 towards the supporting portion 232, so that the end of the human finger can be received therein.

[0021] Specifically, the slide has a specimen area and a barcode area. Among them, the specimen area carries a biological specimen, and the barcode area has a barcode for numbering and identifying the corresponding specimen. A hollow area 234 corresponding to the specimen area is formed on the supporting portion 232, and light can irradiate the specimen area through the hollow area 234. The supporting portion 232 between the hollow area 234 and the pick-and-place operation position 233 corresponds to the barcode area. Therefore, the operator can hold the periphery of the barcode area to pick up and place the slide, thereby avoiding contacting the specimen area and causing contamination to the biological specimen. Further, the supporting portion 232 is in a flat plate shape, and both sides of the specimen area can be attached to the supporting portion 232 along the longitudinal direction of the slide. In this way, the supporting portion 232 can stably support the slide.

[0022] Specifically, the first clamping structure 24a includes a pressing block 241 and a first elastic member 242. The pressing block 241 is slidably connected to the surrounding edge 231 so as to be able to approach or move away from the picking and placing operation position 233. The first elastic member 242 elastically acts on the pressing block 241 to provide a clamping force for clamping the glass slide by the pressing block 241. By moving the pressing block 241 away from the picking and placing operation position 233, the distance between the pressing block 241 and the second clamping structure 24b is increased to facilitate placing the glass slide between the two or removing the glass slide from between the two. When the external force is withdrawn, the first elastic member 242 can apply an elastic force to the pressing block 241 to force the pressing block 241 to approach the picking and placing operation position 233, so that the pressing block 241 and the second clamping structure 24b can jointly clamp the glass slide.

[0023] In some embodiments, sliding blocks 243 are provided on both opposite sides of the pressing block 241. A sliding groove 239 extending in the direction towards the picking and placing operation position 233 is formed on the surrounding edge 231. The two sliding blocks 243 are both engaged with the sliding groove 239 to be able to slide along the sliding groove 239, thereby realizing the sliding of the pressing block 241. In some embodiments, a first limiting member 244 is connected to the pressing block 241. A limiting groove 235 extending in the direction towards the picking and placing operation position 233 is formed on the surrounding edge 231. The first limiting member 244 passes through the limiting groove 235, and the limiting groove 235 cooperates with the first limiting member 244 to limit the maximum sliding stroke of the pressing block 241. The limiting groove 235 is a strip-shaped groove. When the pressing block 241 slides relative to the surrounding edge 231, the first limiting member 244 moves in the limiting groove 235, and both ends of the limiting groove 235 can abut against the first limiting member 244 to constitute two limit positions for the sliding of the pressing block 241. Specifically, the first limiting member 244 is a pin threadedly connected to the pressing block 241. In some embodiments, a guiding member 236 is connected to the surrounding edge 231. A guiding groove 245 extending in the direction towards the picking and placing operation position 233 is formed on the pressing block 241. The guiding member 236 cooperates with the guiding groove 245 to guide the pressing block 241. In addition, the guiding groove 245 is a blind groove, and the guiding member 236 is a guiding pin threadedly connected to the surrounding edge 231. The guiding member 236 can abut against the bottom wall of the guiding groove 245 to constitute a stroke limit for the movement of the pressing block 241, so as to be able to shorten the stroke of the pressing block 241 and enable the pressing block 241 to move within a smaller stroke range to achieve the clamping and relaxation of the glass slide. It should be noted that in other embodiments, the arrangement positions of the sliding groove 239 and the sliding block 243, the arrangement positions of the first limiting member 244 and the limiting groove 235, and the arrangement positions of the guiding member 236 and the guiding groove 245 can all be interchanged.

[0024] In some embodiments, a first receiving cavity 246 is formed in the pressing block 241, and a second receiving cavity 237 is formed through the surrounding edge 231. The first clamping structure 24a includes an adjusting member 247 threadedly connected to the second receiving cavity 237. One end of the first elastic member 242 is received in the first receiving cavity 246 and abuts against the pressing block 241, and the other end of the first elastic member 242 is received in the second receiving cavity 237 and abuts against the adjusting member 247. The first elastic member 242 abuts against the pressing block 241 to provide an elastic acting force for the pressing block 241 to clamp the glass slide. By rotating the adjusting member 247, the position of the adjusting member 247 relative to the second receiving cavity 237 is changed, so as to change the pressing degree of the adjusting member 247 on the first elastic member 242, so as to achieve the purpose of adjusting the elastic acting force of the first elastic member 242.

[0025] Specifically, the second clamping structure 24b is a convex block fixedly provided on the surrounding edge 231 and protruding above the supporting portion 232. In this way, the structure of the second clamping structure 24b is relatively simple, and it can abut against the longitudinal end face of the glass slide and serve as a reference position when the glass slide is placed on the supporting portion 232.

[0026] Specifically, the first clamping structure 24a has a first abutting surface 248 that abuts against the glass slide, and the second clamping structure 24b has a second abutting surface 249 that abuts against the glass slide. Both the first abutting surface 248 and the second abutting surface 249 are inclined surfaces. The first abutting surface 248 and the second abutting surface 249 cooperate to apply a clamping force along the longitudinal direction of the glass slide and a pressing force to press the glass slide against the supporting portion 232. It can be understood that both the first abutting surface 248 and the second abutting surface 249 are inclined surfaces that are inclined towards the supporting portion 232. In this way, when the first abutting surface 248 and the second abutting surface 249 jointly clamp the glass slide, the first abutting surface 248 and the second abutting surface 249 apply clamping forces in opposite directions along the longitudinal direction of the glass slide to the glass slide. At the same time, the first abutting surface 248 and the second abutting surface 249 can also apply a pressing force towards the supporting portion 232 to the glass slide, so as to fix the glass slide at a fixed position on the supporting portion 232. Further, the inclination angles of the first abutting surface 248 and the second abutting surface 249 are 30° to 80°, that is, the angles between the first abutting surface 248 and the second abutting surface 249 and the plane where the supporting portion 232 is located are 30° to 80°. Within this angle range, the two abutting surfaces can balance the clamping force and the pressing force.

[0027] Specifically, the main body 23 includes two stoppers 238 arranged at intervals. The two stoppers 238 respectively correspond to the two lateral sides of the glass slide, and limit the glass slide in the lateral direction, thereby defining the installation position of the glass slide between the two stoppers 238. Further, a plurality of stoppers 238 are arranged at intervals in the lateral direction, and the installation position of the glass slide is defined between any two adjacent stoppers 238, so that a plurality of glass slides can be sequentially placed on the main body 23, and any two adjacent glass slides are separated by the stoppers 238. Further, the hollow area 234 on the support portion 232 corresponds to the specimen areas on a plurality of glass slides at the same time, and at this time the stopper 238 is arranged on the support portion 232. In this way, the entire hollow area 234 only corresponds to the specimen area of the glass slide, so that the specimens can be better compared and analyzed to avoid being affected by any other structure. Further, for the installation positions of the plurality of glass slides defined by the plurality of stoppers 238, a clamping assembly 24 and a picking and placing operation position 233 are correspondingly configured for any one installation position, so as to facilitate the picking and placing operation and the clamping operation of the glass slide at this installation position.

[0028] Combined Figure 2 、 Figure 3 、 Figure 6 、 Figure 7 As shown in, in some embodiments, the conveying mechanism 31 includes a first driving assembly 32, a second driving assembly 33, a dragging assembly 34 and a scanning platform 35. The first driving assembly 32 is used to transport the glass slide holder 22. The second driving assembly 33 is connected to the scanning platform 35 and can drive the scanning platform 35 to move; the first driving assembly 32 and the second driving assembly 33 cooperate with each other to bring the scanning platform 35 close to the glass slide holder 22. The dragging assembly 34 is used to drag the glass slide holder 22 onto the scanning platform 35. Driven by the second driving assembly 33, the scanning platform 35 can move to the detection assembly 11, so that the detection assembly 11 can detect the specimen on the scanning platform 35. Through the mutual cooperation of the components in the conveying mechanism 31, the automatic transfer of the glass slide holder 22 can be realized.

[0029] In some embodiments, the slide holder 22 includes a first magnetic attraction member 25, and the first magnetic attraction member 25 is installed on the main body 23. A second magnetic attraction member (not shown) is installed on the scanning platform 35. The first magnetic attraction member 25 can be magnetically attracted to the second magnetic attraction member. After the dragging component drags the slide holder 22 to the scanning platform 35, through the magnetic attraction between the first magnetic attraction member 25 and the second magnetic attraction member, the slide holder 22 can be quickly positioned at a specific position on the scanning platform 35, thereby preventing the position of the slide holder 22 from changing when the detection component 11 scans and analyzes the slide on the slide holder 22. Specifically, one of the first magnetic attraction member 25 and the second magnetic attraction member is a magnet, and the other is a magnetic conductor that can be magnetically attracted by the magnet, or both the first magnetic attraction member 25 and the second magnetic attraction member are magnets. In other embodiments, the slide holder can also be omitted. At this time, the slide is directly placed in the slide basket 26. At this time, the first magnetic attraction member 25 is installed on the slide.

[0030] In some embodiments, a limiting hole 231a is formed in the surrounding edge 231. The slide basket 26 includes a card slot 27 and a limiting member 28 installed in the card slot 27. The limiting member 28 can be engaged with the limiting hole 231a to lock the slide holder 22 in the card slot 27. Through the mutual cooperation of the limiting hole 231a and the card slot 27, the slide holder 22 can be locked after being installed in the slide basket 26, so as to prevent the slide holder 22 from falling out of the slide basket 26 due to the inclination of the slide basket 26 during the transportation of the slide basket 26. In some embodiments, a card slot 231b is formed in the surrounding edge 231. The conveying mechanism 31 includes a scanning platform 340 and a dragging component 34. The dragging component 34 has a hook 342, and the hook 342 can be engaged with the card slot 231b. The dragging component 34 drives the slide holder 22 to the scanning platform 120, thereby realizing the automatic transportation of the slide holder 22 from the slide basket 26 to the scanning platform 120. It should be noted that in other embodiments, the slide holder can also be omitted. At this time, the limiting hole and the card slot are directly formed on the slide. The slide is locked on the slide basket 26 through the cooperation of the limiting member 28 and the limiting hole on the slide, and the slide is dragged through the cooperation of the hook 342 and the card slot on the slide.

[0031] Combined with Figure 4 and Figure 5As shown, specifically in this embodiment, the slide basket 26 includes a card slot 27 and a limiting member 28. Inside the card slot 27, there is a card position 271 for accommodating the slide holder 22. The limiting member 28 is installed inside the card slot 27. The limiting member 28 includes a connecting portion 281 and a limiting portion 282 connected to the connecting portion 281. Under the action of a first acting force, the limiting portion 282 is misaligned with the card position 271, so that the limiting member 28 is in an unlocked state; under the action of a second acting force, the limiting member 28 moves relative to the card slot 27, and the limiting portion 282 can be aligned with the card position 271, so that the limiting member 28 is in a locked state; the directions of the first acting force and the second acting force are opposite.

[0032] By applying a first acting force to the limiting member 28 to make the limiting member 28 in an unlocked state, the slide holder 22 can be placed into or taken out of the card slot 27, so that the slide holder 22 can be introduced into or exported from the card position 271; and by applying a second acting force to the limiting member 28 to make the limiting member 28 in a locked state, the limiting portion 282 can be engaged with the limiting hole 231a on the slide holder 22 to lock the slide holder 22 on the card position 271, so as to prevent the slide holder 22 from sliding out of the slide basket 26 during the transportation of the slide basket 26.

[0033] Specifically, the card position 271 extends in the horizontal direction and has a starting end and a terminal end opposite to the starting end. The slide holder 22 is introduced into the card position 271 from the starting end and is installed in place when it moves to the terminal end. The limiting member 28 is located on one side of the terminal end, so as not to affect the introduction or export of the slide holder 22, and at the same time, it can lock the slide holder 22 when the slide holder 22 is installed in place. The limiting member 28 can move relative to the card slot 27 in the vertical direction to switch between the unlocked state and the locked state.

[0034] Furthermore, a plurality of card positions 271 are sequentially provided in the card bin 27 along the vertical direction. There are a plurality of limiting parts 282, and the plurality of limiting parts 282 are arranged at intervals along the vertical direction and correspond to the plurality of card positions 271 one by one. By providing the plurality of card positions 271, a plurality of slide racks 22 can be sequentially placed in the card bin 27 along the vertical direction, so as to realize the neat placement of the slide racks 22. And the plurality of limiting parts 282 can correspond to the slide racks 22 placed at the card positions 271 one by one. During the movement of the limiting member 28, the plurality of limiting parts 282 can act simultaneously to unlock or lock the plurality of slide racks 22 synchronously, thereby improving the operation efficiency. It should be noted that support bars 272 are correspondingly installed on the opposite inner wall surfaces of the card bin 27, and the two support bars 272 constitute the support for the slide rack 22. There is a receiving space above the support bar 272 that exceeds the volume of the slide rack 22, and the part of the receiving space that can be used to accommodate the slide rack 22 is the card position 271. Therefore, when the limiting part 282 is aligned with the card position 271, it can be engaged with the limiting hole 231a on the slide rack 22 to present a locked state, and when the limiting part 282 is misaligned with the card position 271, it presents an unlocked state.

[0035] Specifically, the connecting part 281 has a rod-shaped structure, and the limiting part 282 extends circumferentially along the connecting part 281 to form a ring shape. The plurality of limiting parts 282 are arranged at intervals along the axial direction of the connecting part 281, so that the limiting member 28 has a rod structure with alternating thick and thin parts. Further, the limiting hole 231a on the slide rack 22 extends radially and penetrates the slide rack 22 to have a notch. It can be understood that the limiting hole 231a penetrates the slide rack 22 along the thickness direction of the slide rack 22 and extends radially along the limiting hole 231a to the edge of the slide rack 22, so that the limiting hole 231a has a notch. The diameter of the connecting part 281 is smaller than the diameter of the notch, and the diameter of the limiting part 282 is larger than the diameter of the notch. In this way, when the limiting member 28 is in the unlocked state, the limiting part 282 is misaligned with the card position 271, and the connecting part 281 can enter or exit the limiting hole 231a through the notch, so that the slide rack 22 can be inserted into or removed from the card position 271; after the slide rack 22 is inserted into the card position 271, by moving the limiting member 28 along the vertical direction, the limiting part 282 enters the limiting hole 231a, and since the limiting part 282 cannot be exported through the notch, the locking of the limiting member 28 to the slide rack 22 is realized.

[0036] Specifically, the card bin 27 has a top surface 273 and a bottom surface 274 opposite to the top surface 273. The connecting portion 281 has a rod-shaped structure, and one end thereof penetrates and protrudes from the bottom surface 274. When the bottom surface 274 is placed on the placement platform, the placement platform abuts against the connecting portion 281 to provide a first acting force for the limiting member 28. Thus, when the slide basket 26 is placed on the placement platform, since the placement platform first contacts the connecting portion 281 and applies a holding force to the connecting portion 281, the limiting member 28 moves relative to the card bin 27 until the limiting member 28 and the bottom surface 274 of the card bin 27 jointly contact the placement platform. At this time, the slide basket 26 is stably placed on the placement platform. During this process, the placement platform provides a first acting force for the limiting member 28, so that the limiting member 28 is in an unlocked state, facilitating the operator to take out or put the slide basket 26 into the slide rack 22. It can be understood that the placement platform can be a specially provided platform for placing the slide basket 26, or can be understood as the ground.

[0037] Specifically, the slide basket 26 includes an elastic member 29. The elastic member 29 abuts against the limiting member 28 to provide a second acting force for the limiting member 28. When the slide basket 26 is lifted from the placement platform, since the first acting force of the placement platform on the limiting member 28 disappears, under the elastic action of the elastic member 29, the limiting member 28 can be forced to move relative to the card bin 27 to present a locked state, locking the slide rack 22 in the slide basket 26. Thus, without any specific operation by the operator, the limiting member 28 can be automatically converted into the required state according to the needs of the use environment, so that the slide basket 26 structure has the function of automatically locking and unlocking the slide rack 22, and the overall structure is simple and convenient to use.

[0038] Specifically, the elastic member 29 is a spring disposed on the top surface 273. One end of the spring abuts against the top surface 273, and the other end abuts against the limiting member 28. The second acting force is an elastic thrust force towards the bottom surface 274. In other embodiments, the elastic member 29 is a tension spring disposed on the bottom surface 274. One end of the tension spring is connected to the bottom surface 274, and the other end is connected to the limiting member 28. The second acting force is an elastic pulling force towards the bottom surface 274. Therefore, only by making the elastic member 29 apply an elastic acting force towards the bottom surface 274 to the limiting member 28, when the slide basket 26 is lifted, the limiting member 28 can be automatically reset to the locked state. It should be noted that in other embodiments, the elastic member 29 can also be omitted, and the gravity of the limiting member 28 itself enables the limiting member 28 to move relative to the card bin 27 to provide a force for the state change of the limiting member 28 from the unlocked state to the locked state.

[0039] Combined with Figure 1 、 Figure 6 、 Figure 7As shown, in some embodiments, the conveying mechanism 31 is used to convey the slide rack 22. Specifically, since there are multiple slide racks 22 carried in the slide basket 26, at this time, the conveying mechanism 31 can convey the slide racks 22 in the slide basket 26 one by one into the field of view of the detection assembly 11. Specifically, the conveying mechanism 31 includes a first driving assembly 32, a second driving assembly 33, a dragging assembly 34 and a scanning platform 35. Among them, the first driving assembly 32 is used to support the slide basket 26 and drive the slide basket 26 to lift and lower, so that the slide basket 26 moves to the target height. The second driving assembly 33 is connected to the scanning platform 35 to drive the scanning platform 35 to move, so that the scanning platform 35 moves relative to the detection assembly 11. The first driving assembly 32, under the mutual cooperation of the first driving assembly 32 and the second driving assembly 33, can bring the scanning platform 35 close to the slide rack 22 on the slide basket 26. The dragging assembly 34 can engage with the slide rack 22 in the slide basket 26 and drag the slide rack 22 onto the scanning platform 35, or drag the slide rack 22 from the scanning platform 35 to the slide basket 26. In this way, through the mutual cooperation of the components in the conveying mechanism 31, the slide rack 22 can be stably dragged from the slide basket 26 into the field of view of the detection assembly 11, and after the detection is completed, the slide rack 22 can be stably dragged back into the slide basket 26. During the whole process, the slide rack 22 can be stably supported without the problems of falling and damaging the specimen, thereby realizing the stable conveying of the slide rack 22.

[0040] Specifically, the first driving assembly 32 includes a placement platform 321 and a first driving structure 322. The placement platform 321 is used to carry the slide basket 26, and the first driving structure 322 is connected to the placement platform 321 to drive the placement platform 321 to lift and lower. By bringing the scanning platform 35 close to the slide racks 22 at different heights in the slide basket 26, the conveying of the slide racks 22 at different height positions can be realized. In addition, the first driving assembly 32 provides a placement platform 321 for the slide basket 26. After the slide basket 26 is placed on the placement platform 321, the placement platform 321 acts on the limiting member 28 to make the limiting member 28 in an unlocked state, which is beneficial for the dragging assembly 34 to take out the slide rack 22 from the slide basket 26 and transport the slide rack 22 onto the scanning platform 35, or drag the slide rack 22 on the scanning platform 35 back into the slide basket 26. Further, the first driving structure 322 is a linear translation structure composed of a support 322a, a motor 322b, a lead screw 322c and a slider 322d. Specifically, the placement platform 321 is connected to the slider 322d. In other embodiments, the first driving structure 322 can also be an electric cylinder, a pneumatic / hydraulic cylinder, a belt drive, a chain drive or other driving structures that can realize linear translation. In other embodiments, the first driving assembly 32 can also directly convey the slide rack 22, and at the same time, it can also convey the slide rack 22 in the horizontal direction.

[0041] Specifically, the second driving assembly 33 includes a second driving structure 331 and a sliding platform 332. The scanning platform 35 is slidably connected to the sliding platform 332 and slides relative to the sliding platform 332 in the first direction under the driving of the second driving structure 331, where the first direction is the direction of approaching or departing from the slide basket 26. Thus, under the driving of the second driving structure 331, the scanning platform 35 slides relative to the sliding platform 332 and approaches the slide rack 22.

[0042] Further, the second driving assembly 33 includes a frame 333. The sliding platform 332 is slidably connected to the frame 333 and slides relative to the frame 333 in the second direction under the driving of the second driving structure 331, where there is an included angle between the second direction and the first direction. It can be understood that under the driving of the second driving structure 331, the sliding platform 332 drives the scanning platform 35 to move relative to the frame 333 in the second direction. Thus, the scanning platform 35 can not only move relative to the detection assembly 11 in the first direction, but also move relative to the detection assembly 11 in the second direction, so that the specimen on the slide can be directly opposite to the detection assembly 11, which helps the detection assembly 11 better analyze and detect the slide on the scanning platform 35. Specifically, in this application, the first direction and the second direction are two mutually perpendicular directions on the horizontal plane. For example, if the first direction is the X-axis direction in the coordinate system, then the second direction is the Y-axis direction in the coordinate system. The second driving structure 331 can be an electric cylinder, a pneumatic / hydraulic cylinder, a belt drive, a chain drive or other driving structures capable of realizing linear translation, or a combination of multiple linear translation driving structures, so as to achieve the purpose of enabling the scanning platform 35 to translate in multiple directions.

[0043] Specifically, the dragging assembly 34 includes a third driving structure 341 and a hook 342. The third driving structure 341 is connected to the hook 342 and drives the hook 342 to move in the first direction. When the hook 342 is engaged with the slot 231b on the slide rack 22, since the third driving structure 341 drives the hook 342 to move in the first direction, the hook 342 drives the slide rack 22 to move in the first direction, thereby realizing the dragging of the slide rack 22.

[0044] Further, the hook 342 includes a connecting body 342a and a hook body 342b. The connecting body 342a has a rod-like structure. The shape of the hook body 342b is adapted to the shape of the card slot 231b and can abut against the inner wall surface of the card slot 231b in the first direction. It can be understood that after the hook 342 is received in the card slot 231b, the hook 342 abuts against the inner wall surface of the card slot 231b in the first direction, so as to realize the dragging of the slide holder 22 by the hook 342. Specifically, the hook body 342b includes a connecting section and a clamping section. One end of the connecting section is connected to the connecting body 342a, and the clamping section is horizontally arranged at the other end of the connecting section. Specifically, the clamping section and the connecting section cooperate with each other to make the hook body 342b have a "T" - shaped structure. In other embodiments, the hook body 342b can also have an "L" - shaped structure. In addition, the end face area of the connecting section is smaller than the end face area of the connecting body 342a, so that the hook 342 has an "I" - shaped structure. With such a setting, when the dragging component 34 pushes the slide holder 22 from the scanning platform 35 back into the slide basket 26, the end face of the connecting body 342a can abut against the outer wall surface of the slide holder 22, and also exert a pushing force on the slide holder 22 to ensure the smooth movement of the slide holder 22.

[0045] Specifically, the third driving structure 341 and the first driving component 32 cooperate with each other to make the hook 342 engage with the card slot 231b. It can be understood that when the first driving component 32 drives the slide holder 22 to rise to the target height, the third driving structure 341 drives the hook 342 to move in the first direction, so as to be positioned directly above or below the card slot 231b. Then, by driving the slide holder 22 to move by the first driving component 32, the hook 342 is just received in the card slot 231b to achieve engagement with the card slot 231b.

[0046] Specifically, the dragging component 34 is installed on the scanning platform 35, and the dragging component 34 can move synchronously with the scanning platform 35. With such a setting, when the second driving structure 331 drives the scanning platform 35 to move in the first direction, the scanning platform 35 drives the dragging component 34 to move synchronously. When the scanning platform 35 approaches the slide holder, the third driving structure 341 acts to realize the dragging of the slide holder 22 by the hook 342. In this way, the driving stroke of the third driving structure 341 can be greatly shortened, which helps to improve the movement stability of the hook 342. Among them, the third driving structure 341 is a linear translation structure composed of a support 341a, a motor 341b, a lead screw 341c and a slider 341d. Specifically, the hook 342 is connected to the slider 341d. In other embodiments, the third driving structure 341 can also be an electric cylinder, a pneumatic / hydraulic cylinder, a belt drive, a chain drive or other driving structures capable of realizing linear translation.

[0047] When the above chromosome scanning device conveys the slide holder 22, the specific slide conveying method is as follows.

[0048]

[0048] The first driving component 32 and the second driving component 33 cooperate to drive the scanning platform 35 to approach the glass slide. The first driving component 32 drives the glass slide basket 26 to move up and down, and the second driving component 33 drives the scanning platform 35 to move, so that the scanning platform 35 approaches the glass slide. Specifically, as a result of the scanning platform 35 approaching the glass slide, the scanning platform 35 is aligned with the support bar 272 of the glass slide support frame 22. At the same time, the hook in the dragging component is also engaged with the slot 231b, so as to prepare for the dragging component to drag the glass slide.

[0049]

[0049] Specifically, S100 specifically includes the following steps: S110, the first driving component drives the glass slide basket carrying the glass slide to rise until the glass slide and the scanning platform are at a predetermined height difference position, so that the hook is misaligned with the glass slide. Under the driving action of the first driving component 32, the glass slide basket 26 moves in the vertical direction and gradually rises. When there is a predetermined height difference between the support bar 272 corresponding to the glass slide to be dragged and the plane where the scanning platform 35 is located, the glass slide basket 26 stops. In addition, at this position, the hook 342 in the dragging component 34 is exactly misaligned with the glass slide, so as to be able to correspond to the gap between two glass slides, that is, the position above the glass slide to be dragged. In this way, it is beneficial for the hook 342 to extend into this gap to be opposite to the slot 231b on the glass slide in the vertical direction. In other embodiments, the hook 342 can also correspond to the lower gap of the glass slide to be dragged. At this time, in order to enable the hook 342 to be successfully engaged with the slot 231b, the slot 231b should be placed outside the support bar 272 to prevent being blocked by the support bar 272.

[0050]

[0050] S120, make the hook move in the first direction until the hook is opposite to the slot on the glass slide. Under the driving action of the third driving structure 341 in the dragging component 34, the hook 342 moves in the first direction to one side of the glass slide to be dragged, so that the hook 342 is opposite to the slot 231b on the glass slide.

[0051]

[0051] S130, the first driving component 32 drives the glass slide basket 26 to move a predetermined height, so that the hook 342 is engaged with the slot 231b, and the glass slide approaches the scanning platform 35. Driving the glass slide basket 26 by the first driving component 32 to move a predetermined height can just make the support bar 272 aligned with the scanning platform 35. And due to the movement of the glass slide basket 26 and the glass slide in the vertical direction, the hook 342 is also exactly engaged with the slot 231b. In this way, the cooperation between the hook 342 and the slot 231b and the approach of the glass slide to the scanning platform 35 can be completed at one time, without being divided into two steps of operation, so as to optimize the operation steps and save operation time.

[0052] Specifically, in an embodiment where the dragging component 34 is installed on the scanning platform 35 and the dragging component 34 can move synchronously with the scanning platform 34, before S120, there is also a step S150: The second driving component 33 drives the scanning platform 35 and the hook 342 to move in the first direction to approach the slide basket 26. It can be understood that under the drive of the second driving component 33, the scanning platform and the dragging component move synchronously to approach the slide basket. Thus, after the scanning platform moves in place, only the third driving structure 341 needs to act to make the hook 342 continue to approach the slide rack 22. In this way, the driving stroke of the third driving structure 341 can be greatly shortened, which helps to improve the movement smoothness of the hook 342.

[0053] Specifically, the second driving component 33 includes a second driving structure 331 and a sliding platform 332; the scanning platform 35 is slidably connected to the sliding platform 332 and slides relative to the sliding platform 332 in the first direction under the drive of the second driving structure 331. In an embodiment where the second driving component 33 includes a frame 333, the sliding platform 332 is slidably connected to the frame 333 and slides relative to the frame 333 in the second direction under the drive of the second driving structure 331. Since the second driving structure 331 can drive the sliding platform 332 to drive the scanning platform 35 to move in the second direction, before S150, there is also a step S160: Move the scanning platform 35 in the second direction so that the scanning platform 35 and the support bar 272 are aligned in the first direction. It can be understood that the scanning platform 35 needs to be moved to the intersection position of the second direction and the first direction in the second direction first, and then the scanning platform 35 can be moved in the first direction to be aligned with the support bar 272.

[0054] S200. The dragging component drags the slide to the scanning platform. When the hook 342 is engaged with the card slot 231b and the slide approaches the scanning platform 35, the third driving structure 341 can be driven to drive the hook 342 to move to drive the slide to move, so as to realize the stable dragging of the slide and make the slide move smoothly from the support bar 272 to the scanning platform 35. During the process of the hook 342 dragging the slide to move, since the first magnetic member 25 is provided on the slide and the second magnetic member is provided on the scanning platform 35, when the first magnetic member 25 and the second magnetic member are magnetically attracted, the slide moving to the target position on the scanning platform 35 is also stably locked on the scanning platform 35.

[0055] In S300, the second driving component drives the scanning platform 35 to move close to the detection component, and drives the scanning platform 35 to move away from the detection component after the detection by the detection component is completed. After the glass slide is dragged onto the scanning platform 35, the second driving component 33 can drive the scanning platform 35 to move away from the glass slide basket 26, so as to transport the glass slide into the field of view of the detection component 11, facilitating the detection component 11 to analyze the glass slide. After the detection component 11 finishes detecting the glass slide, the second driving component 33 can be made to drive the scanning platform 35 away from the detection component 11 and gradually close to the glass slide basket 26, making the scanning platform 35 close to the glass slide basket 26 again to prepare for dragging the glass slide back into the glass slide basket 26. It should be noted that in the embodiment where the dragging component 34 is installed on the scanning platform 35, the scanning platform 35 drives the dragging component 34 to move synchronously, and the scanning platform 35 and the dragging component 34 cooperate together to drive the glass slide to move synchronously. It can be understood that after the dragging component 34 drags the glass slide onto the scanning platform 35, the dragging component 34 stops acting, and in the state where the hook 342 is engaged with the card slot 231b, the scanning platform 35, the dragging component 34 and the glass slide move synchronously away from the glass slide basket 26 or close to the glass slide basket 26 after the detection is completed.

[0056] Specifically, after S300, S400 is further included: making the dragging component drag the glass slide from the scanning platform back to the first driving component. The third driving structure 341 in the dragging component 34 drives the hook 342 to move, so as to push the glass slide from the scanning platform 35 back into the glass slide basket 26 located on the first driving component. When it is necessary to transfer another glass slide in the glass slide basket 26, the above steps can be repeated.

[0057] In the chromosome scanning device 10, through the mutual cooperation between the transfer mechanism 31 and the glass slide basket 26, the automatic and stable transfer of the glass slide between the glass slide basket 26 and the scanning platform 120 can be realized. There is no need to manually load the glass slide onto the scanning platform 120, which not only improves the sample processing efficiency, but also can effectively ensure the safety of the transfer and prevent the glass slide from being damaged or the specimen from being contaminated.

[0058] As Figure 8 shown, in some embodiments, the oil dropping mechanism 41 includes an oil bottle 42, an oil pump (not shown) and an oil dropping needle (not shown). The oil bottle 42 is used to store the mirror oil. The oil pump is connected between the oil dropping needle and the oil bottle 42 to pump the mirror oil in the oil bottle 42 to the oil dropping needle. The oil dropping needle points to the field of view of the microscope component 110 and is used to drop the mirror oil onto the glass slide on the scanning platform 120 within the field of view of the microscope component 110.

[0059] Specifically, the oil dripping mechanism 41 includes a detection component 43 connected to an oil bottle 42. The detection component 43 is arranged outside the oil bottle 42. The detection component 43 can detect the weight of the oil bottle 42 in real time and obtain the parameters of the remaining mirror oil in the oil bottle 42. By setting the detection component 43, the content of the remaining mirror oil in the oil bottle 42 can be quantitatively detected. According to this parameter, the operator can directly judge whether the mirror oil needs to be added to the oil bottle 42, so as to accurately grasp the refueling opportunity. In addition, compared with the solutions of detecting the liquid level of the mirror oil in the oil bottle 42 to judge the remaining oil volume, observing whether there are bubbles in the transmission oil pipe to judge whether the mirror oil is used up, calculating the oil consumption per drop of oil to estimate the remaining oil volume, and detecting the remaining oil volume by using ultrasonic waves, the solution of using the detection component 43 to detect the weight of the oil bottle 42 has at least the following advantages: it does not need to contact the mirror oil in the oil bottle 42, thus ensuring the cleanliness of the mirror oil and avoiding contamination of the mirror oil; the detection efficiency is relatively high; the detection accuracy is relatively high; the structure is simple and the cost is low.

[0060] Specifically, the detection component 43 includes a sensor 43a. The sensor 43a includes a substrate 431 and a sensing body 432 mounted on the substrate 431. The oil bottle 42 is mounted on the sensing body 432. The substrate 431 serves as a supporting structure for the sensing body 432 to provide stable horizontal support for the sensing body 432 and the oil bottle 42. Further, the sensor 43a is a weighing sensor, and the weighing sensor can weigh the oil bottle 42 placed thereon to obtain the weight of the oil bottle 42 in real time.

[0061] Further, the detection component 43 further includes a calculation module (not shown). The calculation module is connected to the sensor 43a to calculate the parameter K of the remaining mirror oil in the oil bottle 42, and K = (m3 - m1) / (m2 - m1), where when there is no mirror oil in the oil bottle 42, the weight of the oil bottle 42 detected by the detection component 43 is m1; when the oil bottle 42 is full of mirror oil, the weight of the oil bottle 42 detected by the detection component 43 is m2; the weight of the oil bottle 42 detected by the detection component 43 in real time is m3. It can be understood that the value of (m3 - m1) is the weight of the remaining mirror oil in the oil bottle 42, the value of (m2 - m1) is the total weight of the mirror oil when the oil bottle 42 is full of mirror oil, and K is the ratio of the remaining mirror oil to the total weight of the mirror oil when full. For example, when the detection component 43 detects that m1 is 10 g, m2 is 20 g, and m3 is 12 g, it means that 2 g of the mirror oil with a total weight of 10 g remains. At this time, the parameter K of the remaining mirror oil is 20%.

[0062] Specifically, the sensor 43a includes a mounting base 433, which is connected to the sensing main body 432. The sensing main body 432 is located between the mounting base 433 and the substrate 431. A mounting groove (not labeled in the figure) is formed on the mounting base 433, and at least a part of the oil bottle 42 is received in the mounting groove. Placing the oil bottle 42 in the mounting groove can form a fixed mounting position for the oil bottle 42, and at the same time can ensure the stable position of the oil bottle 42 relative to the sensing main body 432. Moreover, when the oil bottle 42 needs to be refilled, the oil bottle 42 can be taken out of the mounting groove, so that the connection between the oil bottle 42 and the sensing main body 432 is simple and reliable.

[0063] Specifically, the capacity of the oil bottle 42 is 250 ml. The large-capacity oil bottle 42 can store more mirror oil, which can be used for the detection of a larger number of glass slides.

[0064] Specifically, the chromosome scanning device 10 includes a control center (not shown in the figure). The detection component 43 is connected to the control center and sends the parameters of the remaining mirror oil in the oil bottle 42 to the control center. When the parameters are less than the established value, the control center issues a warning prompt. In this way, the operator can refuel the oil bottle 42 according to the warning prompt issued by the control center, which avoids the problem that the operator needs to check the remaining mirror oil in the oil bottle 42 irregularly and can also prevent the operator from forgetting to replace the mirror oil. Further, the established value is set to 20%. It can be understood that when the parameter K of the remaining mirror oil in the oil bottle 42 is less than 20%, the control center will issue a warning prompt to remind the operator to perform the refueling operation. In addition, the chromosome scanning device 10 includes a display (not shown in the figure), and the display is connected to the control center. The display displays the parameters of the remaining mirror oil in the oil bottle 42 and the warning prompt issued by the control center. For example, the display displays the parameters of the remaining mirror oil, and the parameter K value can be directly seen through the display to fully grasp the remaining oil volume in the oil bottle 42. When the parameter K value is lower than the set established value, the parameter K value issues a warning prompt by continuously flashing in an abnormal color or an abnormal icon, thereby reminding the operator to perform the refueling operation.

Claims

1. A chromosome scanning device, characterized in that, Comprising: A microscope assembly; A slide basket, inside which there are card positions for accommodating slides; And A conveying mechanism, including a first driving component, a second driving component, a scanning platform and a dragging component; the first driving component is connected to the slide basket to drive the slide basket to move up and down; the second driving component is connected to the scanning platform to drive the scanning platform to move relative to the microscope assembly; The dragging component is used to drag the slide from the slide basket to the scanning platform, and the microscope assembly is used to scan the slide on the scanning platform; The slide basket includes a card bin and a limiting member installed in the card bin, and there are card positions for accommodating the slides inside the card bin; the limiting member can move relative to the card bin and has a locked state and an unlocked state; when the limiting member is in the unlocked state, the slide can be inserted into or taken out of the card position; When the limiting member is in the locked state, the limiting member locks the slide in the card position; In the locked state, the limiting member protrudes from the bottom surface of the card bin; When the slide basket is placed on the placement platform, the placement platform abuts against the limiting member to make the limiting member move relative to the card bin and be in the unlocked state; The limiting member includes a connecting portion and a limiting portion connected to the connecting portion. The connecting portion has a rod-like structure, and the limiting portion extends circumferentially along the connecting portion to form a ring shape. A plurality of the limiting portions are arranged at intervals along the axial direction of the connecting portion, so that the limiting member has a rod structure with alternating thicknesses. When the limiting portion is misaligned with the card position, the limiting member is in the unlocked state, and when the limiting portion is aligned with the card position, the limiting member is in the locked state.

2. The chromosome scanning device according to claim 1, wherein The first driving component includes a placement platform and a first driving structure connected to the placement platform; the first driving structure is used to drive the placement platform and the slide basket to move up and down.

3. The chromosome scanning device according to claim 1, wherein The slide basket includes an elastic member, and the elastic member elastically acts on the limiting member to provide an elastic acting force for the limiting member to move relative to the card bin and engage with the limiting hole.

4. The chromosome scanning device according to claim 1, wherein, The second driving component includes a second driving structure, a frame and a sliding platform slidably connected to the frame; the scanning platform is slidably connected to the sliding platform; The second driving structure is connected to the scanning platform to drive the scanning platform to slide relative to the sliding platform along a first direction; The second driving structure is connected to the sliding platform to drive the sliding platform to drive the scanning platform to slide relative to the frame along a second direction; There is an included angle between the first direction and the second direction.

5. The chromosome scanning device according to claim 1, wherein The dragging component is installed on the scanning platform, and the dragging component can move synchronously with the scanning platform.

6. The chromosome scanning device according to claim 1 or 5, characterized in that, The dragging component includes a third driving structure and a hook. The third driving structure is connected to the hook and drives the hook to translate linearly to approach or move away from the slide basket. The third driving structure and the first driving component cooperate with each other to make the hook engage with the card slot on the slide.

7. The chromosome scanning device according to claim 1, characterized in that, A first magnetic attraction member is installed on the glass slide, and a second magnetic attraction member is installed on the scanning platform. The first magnetic attraction member can be magnetically attracted to the second magnetic attraction member.

8. The chromosome scanning device according to claim 1, wherein The chromosome scanning device includes an oil dropping mechanism for dropping immersion oil. The oil dropping mechanism includes an oil bottle, an oil pump, and an oil dropping needle. The oil bottle is used for storing immersion oil. The oil pump is connected between the oil dropping needle and the oil bottle to pump the immersion oil in the oil bottle to the oil dropping needle. The oil dropping needle points to the corresponding visual field of the microscope assembly.

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