Delivery of surfactant-soluble anti-dandruff agents

Abstract

The present invention provides a hair care composition comprising from about 14% to about 40% of one or more surfactants; from about 0.1% to 10% of one or more surfactant-soluble anti-dandruff agents; wherein when the hair care composition is diluted to a 1.3% surfactant concentration, it has a ratio of the surfactant diffusion coefficient to the soluble agent diffusion coefficient of less than 0.6 or greater than 1.4.

Description

[0001] This application is a divisional application of an invention patent application with application number 201680023514.6, filed on April 22, 2016, entering the Chinese national phase, and entitled “Delivery of surfactant-soluble anti-dandruff agents”. Technical Field

[0002] The present invention relates to the delivery of surfactant soluble scalp agents from hair care compositions. Background Art

[0003] Antidandruff shampoos have been widely used for treating dandruff and cleaning the hair and scalp for many years, but there is still a need for improved antidandruff shampoos. Generally speaking, antidandruff shampoos are formulated from a combination of an antidandruff agent with a surfactant and an aqueous system, which is intended to deposit the antidandruff agent on the scalp. The antidandruff agent may be an insoluble particulate such as zinc pyrithione, and / or a surfactant soluble material such as meclofenone or oxymetholone. Many antidandruff shampoos use a cationic polymer with an anionic surfactant to form aggregates, which help to deposit the insoluble particulate agent. However, since the soluble agent does not associate with the aggregates formed between the cationic polymer and the anionic surfactant, the aggregates generally do not affect the deposition of the soluble agent. In fact, it can be proven difficult to deposit much more than 1-2% of the soluble agent present in the antidandruff shampoo on the scalp, while the remaining 98-99% of the soluble agent in the formulation is rinsed off. Since many anti-dandruff agents can be expensive, allowing >97% of the soluble agent to be washed away can be a waste of money, and there remains a need for shampoos that can more effectively deposit soluble anti-dandruff agents. Additionally, since consumers continue to desire shampoos that deliver superior anti-dandruff efficacy, and lower agent deposition results in lower anti-dandruff efficacy, there remains a need for shampoos that can deposit a higher percentage of the soluble agents present in anti-dandruff shampoos onto the scalp.

[0004] The association of many types of surfactants with micellar aggregates is a well-known phenomenon. Micelles are usually drawn as static structures of spherical aggregates, but in fact micelles are in dynamic equilibrium with individual surfactant molecules (monomers) that are constantly exchanged between the matrix and the micelles. In addition, the micelles themselves continuously disintegrate and reorganize. Two relaxation processes are involved in micellar solutions. The first is a fast relaxation process called τ1, which is associated with the rapid exchange of monomers between the micelles and the surrounding matrix phase. The second relaxation time τ2 is attributed to the micelle formation and dissolution process (i.e., the lifetime of the micelle). Extensive experimental studies of micellization kinetics by Shah and co-workers (Patist, A., Jha, BK, Oh, SG, and Shah, DO, J. Surfactants Deterg. 2, 317, (1999); James-Smith, MA, Shekhawat, D., and Shah, DO, Tenside Surf. Det. 44, 142 (2007)) showed a strong correlation of τ2 with a variety of detergency properties, including oil solubility in micellar solutions and droplet size in emulsions, as well as surfactant properties such as dynamic surface tension and micelle stability. Their studies also showed a strong inverse correlation of τ2 with other properties such as foaming and submicellar aggregate concentration. Specifically, the studies showed that the maximum τ2 and thus the maximum micelle stability corresponded to both the maximum oil solubility rate and the maximum oil solubility. Therefore, logic would suggest that cleaning compositions with longer τ2, more stable micelles, and faster dissolution rates would be preferred, since such systems would clean better, dissolve larger amounts of oil or surfactant soluble materials more quickly, and should be more stable. However, surprisingly, it has been found that Figure 1 As shown, compositions with surfactant systems having shorter τ2, less stable micelles and slower dissolution rates are preferred. Summary of the invention

[0005] In one embodiment of the present invention, it is directed to a hair care composition comprising from about 14% to about 40% of one or more surfactants; from about 0.1% to 10% of one or more surfactant-soluble anti-dandruff agents; wherein when the hair care composition is diluted to a 1.3% surfactant concentration, it has a ratio of the surfactant diffusion coefficient to the soluble agent diffusion coefficient of less than 0.6 or greater than 1.4. BRIEF DESCRIPTION OF THE DRAWINGS

[0006] Figure 1 is a graphical representation of the dissolution rate of octopirox as a function of surfactant composition.

[0007] Detailed description of embodiments of the present invention

[0008] Unless otherwise indicated, all percentages and ratios used herein are by weight of the total composition. Unless otherwise indicated, all measurements are understood to be made under ambient conditions, wherein "ambient conditions" means conditions at about 25°C, at about one atmosphere of pressure, and at about 50% relative humidity. All numerical ranges are narrower ranges including the end values; the upper and lower range limits described are combinable to form additional ranges not explicitly described.

[0009] The compositions of the present invention may comprise, consist essentially of, or consist of the essential components and optional ingredients described herein. As used herein, "consisting essentially of" means that the composition or component may contain additional ingredients as long as the additional ingredients do not materially change the basic and novel features of the composition or method claimed by the present invention.

[0010] "Applying" or "applying" as used with reference to a composition means applying or spreading the composition of the present invention onto keratinous tissue such as hair.

[0011] "Dermatologically acceptable" means that the compositions or components described are suitable for use in contact with human skin tissue without undue toxicity, incompatibility, instability, allergic response, and the like.

[0012] "Safe and effective amount" refers to an amount of a compound or composition sufficient to significantly induce a positive beneficial effect.

[0013] While the specification concludes with claims which particularly point out and distinctly claim the invention, it is believed that the present invention will be better understood from the following description.

[0014] As used herein, the term "fluid" includes liquids and gels.

[0015] As used herein, articles including "a" and "an" when used in a claim should be understood to mean one or more of what is claimed or described.

[0016] As used herein, "comprises / comprising" means that other steps and other ingredients which do not affect the end result can be added. The term includes "consisting of" and "consisting essentially of."

[0017] As used herein, "mixture" is intended to include a simple combination of substances as well as any compounds that may result from their combination.

[0018] As used herein, unless otherwise indicated, "molecular weight" or "molecular mass" refers to weight average molecular weight.Molecular weight is measured using the industry standard method, gel permeation chromatography ("GPC").

[0019] Where content ranges are given, these should be understood to be the total amount of the ingredient in the composition, or where more than one material falls within an ingredient definition, the total amount of all ingredients in the composition that meet the definition.

[0020] For example, if the composition comprises 1% to 5% fatty alcohol, a composition comprising 2% stearyl alcohol and 1% cetyl alcohol and no other fatty alcohols would fall within the range.

[0021] The amount of each specific ingredient or mixtures thereof described below may comprise up to 100% (or 100%) of the total amount of one or more ingredients in the hair care composition.

[0022] As used herein, "personal care composition" includes products such as shampoos, shower gels, liquid hand soaps, hair colorants, facial cleansers, and other surfactant-based liquid compositions.

[0023] As used herein, the terms "including," "comprising," and "containing" are intended to be non-limiting, and are interpreted to mean "having," "having," and "comprising," respectively.

[0024] All percentages, parts and ratios are based upon the total weight of the compositions of the present invention, unless otherwise specified. All such weights as they pertain to listed ingredients are based on the active level and, therefore, do not include carriers or by-products that may be included in commercially available materials.

[0025] Unless otherwise indicated, all component or composition levels are in reference to the active portion of that component or composition and are exclusive of impurities, for example, residual solvents or by-products, which may be present in commercially available sources of such component or composition.

[0026] It should be understood that each maximum numerical limit given throughout this specification includes each lower numerical limit, as if the lower numerical limit was explicitly written herein. Each minimum numerical limit given throughout this specification will include each higher numerical limit, as if the higher numerical limit was explicitly written herein. Each numerical range given throughout this specification will include each narrower numerical range that falls within this wider numerical range, as if the narrower numerical range was fully explicitly written herein.

[0027] While the τ2 and micelle stability of the surfactant system and the solubility of the surfactant-soluble agent in the system are important, equally important is the stability of the surfactant micelles and the solubility and dissolution rate of the agent in the system after dilution, such as when the cleaning composition is applied to the head during use. One way to understand the solubility and relevance of soluble agents in surfactant systems upon dilution is to measure the diffusion coefficients of the surfactant and the surfactant-soluble agent in the diluted sample by NMR. If the diffusion coefficients of the surfactant and the agent are similar, such that the ratio of the two coefficients is close to 1.0, it can be inferred that the surfactant-soluble agent is within or closely associated with the surfactant micelle. However, if the diffusion coefficients of the surfactant and the agent are very different, such that the ratio of the two coefficients is significantly greater than or less than 1.0, it can be inferred that the surfactant-soluble agent is not within or associated with the surfactant micelle. This, in turn, means that the surfactant-soluble agent is less soluble in the diluted surfactant in the latter case.

[0028] It has been discovered that cleansing compositions comprising a soluble anti-dandruff agent having a ratio of surfactant diffusion coefficient to soluble diffusion coefficient of less than 0.8 or greater than 1.2 when diluted to a 1.3% surfactant concentration can deposit the soluble agent ~1.4X or more efficiently than compositions comprising a soluble anti-dandruff agent having a diffusion coefficient ratio approaching 1.0.

[0029] Without being bound by theory, the increased deposition efficiency exhibited by embodiments of the present invention can surprisingly be further enhanced by the additional incorporation of a combination of an oil that phase separates upon dilution and a cationic polymer that forms aggregates upon dilution. The aggregates aid in the deposition of the oil in which the surfactant-soluble agent should at least partially dissolve, thereby resulting in a stepwise increase in the total percentage of soluble agent deposited.

[0030] Surfactant-soluble agents are defined as materials that are insoluble in water but soluble in an aqueous solution of 10% sodium laureth-1 sulfate. Conventional methods can be used to determine solubility. Such methods can include where the solubility of the material of interest can be first determined by visual assessment that the material containing the sodium laureth-1 sulfate mixture is uniform, then filling a glass jar with the material containing the sodium laureth-1 sulfate mixture, and then placing a Class 2 standard red laser pointer, such as a Quartet Class 2 Standard Laser Pointer (Model MP-1202Q), against the side of the jar and shining the laser through the jar. If the material is soluble in the laureth-1 solution, the laser light will not be scattered, resulting in only an observable red dot appearing on the side of the jar opposite the laser pointer, and no visible red laser beam is observed through the solution.

[0031] Soluble anti-dandruff agent

[0032] The anti-dandruff agent may be a material or mixture selected from the following: azoles, such as imidacloprid, ketoconazole, itraconazole, econazole and sinoconazole; hydroxypyridones, such as octopirox (octopirox olamine), ciclopirox, rilopirox, and MEA-hydroxyoctoxypyridone; keratolytic agents, such as salicylic acid and other hydroxy acids; methoxyacrylates, such as azoxystrobin and metal chelators such as 1,10-phenanthroline.

[0033] In one embodiment, the azole antimicrobial is an imidazole selected from the group consisting of benzimidazole, benzothiazole, bifonazole, butoconazole nitrate, imidacloprid, clotrimazole, kruconazole, eberconazole, econazole, new conazole, fenticonazole, fluconazole, flutriazole, isoconazole, ketoconazole, lannoconazole, metronidazole, miconazole, neticonazole, omoconazole, oxiconazole nitrate, sertaconazole, sulconazole nitrate, tioconazole, thiazole and mixtures thereof, or the azole antimicrobial is a triazole selected from the group consisting of terconazole, itraconazole and mixtures thereof. In one embodiment, the azole microbial agent is ketoconazole. In one embodiment, the only antimicrobial is ketoconazole.

[0034] In one embodiment, the soluble anti-dandruff agent may be present in an amount from about 0.1% to 10%, in another embodiment from about 0.25% to 8%, and in another embodiment from about 0.5% to 6%.

[0035] A. Detergent surfactant

[0036] The hair care composition may comprise greater than about 14% by weight of a surfactant system that provides cleaning performance to the composition, and in one embodiment greater than 20% by weight of a surfactant system that provides cleaning performance to the composition. The surfactant system comprises an anionic surfactant, and / or a combination of anionic surfactants, and / or a combination of anionic surfactants and a co-surfactant selected from amphoteric co-surfactants, zwitterionic co-surfactants, nonionic co-surfactants, and mixtures thereof. Various examples and descriptions of detersive surfactants are shown in U.S. Patent No. 8,440,605; U.S. Patent Application Publication No. 2009 / 155383; and U.S. Patent Application Publication No. 2009 / 0221463, which are incorporated herein by reference in their entirety.

[0037] In one embodiment, the hair care composition may comprise from about 14% to about 40%, from about 15% to about 36%, from about 18% to about 32%, and / or from about 20% to about 28% by weight of one or more surfactants.

[0038] Suitable anionic surfactants for use in the composition are alkyl sulfates and alkyl ether sulfates. Other suitable anionic surfactants are water-soluble salts of organic sulfuric acid reaction products. Other suitable anionic surfactants are the reaction products of fatty acids esterified with isethionates and neutralized with sodium hydroxide. Other similar anionic surfactants are described in U.S. Pat. Nos. 2,486,921; 2,486,922; and 2,396,278, which are incorporated herein by reference in their entirety.

[0039] Exemplary anionic surfactants for use in the hair care composition include ammonium lauryl sulfate, ammonium laureth sulfate, ammonium C10-15 alkyl polyoxyethylene ether sulfate, C10-15 alkyl ammonium sulfate, C11-15 ammonium sulfate, decyl sulfate, ammonium decyl polyoxyethylene ether sulfate, undecyl sulfate, ammonium undecyl polyoxyethylene ether sulfate, triethylamine lauryl sulfate, triethylamine laureth sulfate, triethanolamine lauryl sulfate, triethanolamine laureth sulfate, monoethanolamine laureth sulfate, monoethanolamine laureth sulfate, diethanolamine laureth sulfate, diethanolamine laureth sulfate, sodium lauric acid monoglyceride sulfate, sodium lauryl sulfate, sodium laureth sulfate, sodium C10-15 alkyl polyoxyethylene ether sulfate, sodium C10-15 alkyl sulfate, C11-15 alkyl Sodium sulfate, sodium decyl sulfate, sodium decyl polyoxyethylene sulfate, sodium undecyl sulfate, sodium undecyl polyoxyethylene sulfate, potassium lauryl sulfate, potassium laureth sulfate, potassium C10-15 alkyl polyoxyethylene sulfate, potassium C10-15 alkyl sulfate, potassium C11-15 alkyl sulfate, potassium decyl sulfate, potassium decyl polyoxyethylene sulfate, potassium undecyl sulfate, potassium undecyl sulfate, sodium lauryl sarcosinate, sodium lauroyl sarcosinate, lauryl sarcosine, cocoyl sarcosine, ammonium cocoyl sulfate, ammonium lauroyl sulfate, sodium cocoyl sulfate, sodium lauroyl sulfate, potassium cocoyl sulfate, potassium lauryl sulfate, triethanolamine lauryl sulfate, triethanolamine lauryl sulfate, monoethanolamine cocoyl sulfate, monoethanolamine lauryl sulfate, sodium tridecylbenzene sulfonate, sodium dodecylbenzene sulfonate, sodium cocoyl isethionate, and combinations thereof. In another embodiment, the anionic surfactant is sodium lauryl sulfate or sodium laureth sulfate.

[0040] The composition of the present invention may also comprise an anionic surfactant selected from the group consisting of:

[0041] a R1 O(CH2CHR3O) y SO3M;

[0042] b CH3(CH2) zCHR2 CH2 O(CH2 CHR3O) y SO3M; and

[0043] c mixtures thereof,

[0044] Where R1 represents CH3(CH2) 10 , R2 represents H or a hydrocarbon group containing 1 to 4 carbon atoms such that the sum of the carbon atoms in z and R2 is 8, R3 is H or CH3, y is 0 to 7, when y is not zero (0), the average value of y is about 1, and M is a monovalent or divalent positively charged cation.

[0045] Suitable anionic alkyl sulfate and alkyl ether sulfate surfactants include, but are not limited to, those with alkyl side chains synthesized from C8 to C18 branched alcohols, which can be selected from Guerbet alcohols, alcohols derived from aldol condensation, oxo alcohols, and mixtures thereof. Non-limiting examples of 2-alkyl branched alcohols include oxo alcohols such as 2-methyl-1-undecanol, 2-ethyl-1-decanol, 2-propyl-1-nonanol, 2-butyl-1-octanol, 2-methyl-1-dodecanol, 2-ethyl-1-undecanol, 2-propyl-1-decanol, 2-butyl-1-nonanol, 2-pentyl-1-octanol, 2-pentyl-1-heptanol, and the like sold under the trade names (Sasol), (Sasol) and (Shell), as well as Guerbet alcohols and alcohols derived from aldol condensation such as 2-ethyl-1-hexanol, 2-propyl-1-butanol, 2-butyl-1-octanol, 2-butyl-1-decanol, 2-pentyl-1-nonanol, 2-hexyl-1-octanol, 2-hexyl-1-decanol, and (Sasol) or as alcohol ethoxylates and alkoxylates under the trade name LUTENSOL (BASF) and LUTENSOL Those sold by BASF.

[0046] The anionic alkyl sulfates and alkyl ether sulfates may also include those synthesized from C8 to C18 branched chain alcohols derived from butene or propylene, sold under the trade name EXXAL TM (Exxon) and The compositions of the present invention may also include sodium tridecyl sulfate.

[0047] The composition of the present invention may also include anionic alkyl sulfosuccinates and alkyl ether sulfosuccinates, and / or dialkyl sulfosuccinates and dialkyl ether sulfosuccinates, and mixtures thereof. Dialkyl sulfosuccinates and dialkyl ether sulfosuccinates may be C6-15 straight or branched dialkyl sulfosuccinates and dialkyl ether sulfosuccinates. The alkyl moiety may be symmetrical (i.e., identical alkyl moieties) or asymmetrical (i.e., non-identical alkyl moieties). Non-limiting examples include: disodium lauryl sulfosuccinate, disodium lauryl polyoxyethylene ether sulfosuccinate, sodium ditridecyl sulfosuccinate, sodium dioctyl sulfosuccinate, sodium dihexyl sulfosuccinate, sodium dicyclohexyl sulfosuccinate, sodium diamyl sulfosuccinate, sodium diisobutyl sulfosuccinate, linear bis(tridecyl) sulfosuccinate, and mixtures thereof.

[0048] The hair care composition may include an auxiliary surfactant. The auxiliary surfactant may be selected from amphoteric surfactants, zwitterionic surfactants, nonionic surfactants, and mixtures thereof. The auxiliary surfactant may include, but is not limited to, lauramidopropyl betaine, cocoamidopropyl betaine, lauryl hydroxysultaine, sodium lauroamphoacetate, disodium cocoamphodiacetate, cocamide monoethanolamide, and mixtures thereof.

[0049] The hair care composition may also contain from about 0.25% to about 15%, from about 2% to about 14%, from about 3% to about 13% by weight of one or more amphoteric co-surfactants, zwitterionic co-surfactants, nonionic co-surfactants, or mixtures thereof.

[0050] Suitable amphoteric or zwitterionic surfactants for use in the hair care compositions herein include those known for use in shampoos or other personal care cleansing. Non-limiting examples of suitable zwitterionic or amphoteric surfactants are described in U.S. Patents 5,104,646 and 5,106,609, which are incorporated herein by reference in their entirety.

[0051] Suitable amphoteric auxiliary surfactants for use in the composition include those described as derivatives of aliphatic secondary and tertiary amines, wherein the aliphatic group may be linear or branched, and wherein one of the aliphatic substituents contains from about 8 to about 18 carbon atoms, and one aliphatic substituent contains an anionic group such as carboxyl, sulfonate, sulfate, phosphate, or phosphonate. Suitable amphoteric surfactants include, but are not limited to, those selected from the following: sodium cocoylaminopropionate, sodium cocoylaminodipropionate, sodium cocoamphoacetate, sodium cocoamphohydroxypropylsulfonate, sodium cocoamphopropionate, sodium corn amphopropionate, sodium lauraminopropionate, sodium lauroamphoacetate, sodium lauroamphodiacetate, sodium lauroamphohydroxypropylsulfonate, sodium lauroamphopropionate, sodium corn amphopropionate, sodium lauriminodipropionate, ammonium cocoylaminopropionate, ammonium cocoamphodipropionate, Ammonium cocoamphoacetate, ammonium cocoamphodiacetate, ammonium cocoamphohydroxypropyl sulfonate, ammonium cocoamphopropionate, ammonium cornamphopropionate, ammonium laurylaminopropionate, ammonium lauroamphoacetate, ammonium lauroamphodiacetate, ammonium lauroamphohydroxypropyl sulfonate, ammonium lauroamphopropionate, ammonium cornamphopropionate, ammonium lauryliminodipropionate, triethanolamine cocoaminopropionate, triethanolamine cocoaminodipropionate, triethanolamine cocoamphoacetate, triethyl cocoamphohydroxypropyl sulfonate Alcoholamine, triethanolamine cocoamphopropionate, triethanolamine corn oil amphopropionate, triethanolamine lauryl propionate, triethanolamine lauroamphoacetate, triethanolamine lauroamphohydroxypropyl sulfonate, triethanolamine lauroamphopropionate, triethanolamine corn oil amphopropionate, triethanolamine lauriminodipropionate, cocoamphodipropionic acid, disodium capryloamphodiacetate, disodium capryloamphodipropionate, disodium capryloamphodiacetate, disodium capryloamphodipropionate, disodium cocoamphocarboxyethyl hydroxypropyl sulfonate Sodium, Disodium Cocoamphodiacetate, Disodium Cocoamphodipropionate, Disodium Dicarboxyethyl Cocopropylenediamine, Disodium Laureth-5 Carboxyamphodiacetate, Disodium Lauriminodipropionate, Disodium Lauroamphodiacetate, Disodium Lauroamphodipropionate, Disodium Oleylamphodipropionate, Disodium PPG-2-Isodeceth-7 Carboxyamphodiacetate, Laurylaminopropionic acid, Lauroamphodipropionic acid, Laurylaminopropyl glycine, Lauryl diethylenediaminoglycine, and mixtures thereof.

[0052] The composition may comprise a zwitterionic co-surfactant, wherein the zwitterionic co-surfactant is a derivative of an aliphatic quaternary ammonium, phosphonium and sulfonium compound, wherein the aliphatic group may be straight chain or branched, and wherein one of the aliphatic substituents contains from about 8 to about 18 carbon atoms and one aliphatic substituent contains an anionic group such as carboxyl, sulfonate, sulfate, phosphate or phosphonate. The zwitterionic surfactant may be selected from: cocoamidoethyl betaine, cocoamidopropylamine oxide, cocoamidopropyl betaine, cocoamidopropyl dimethylaminohydroxypropyl hydrolyzed collagen, cocoamidopropyl dimethylammonium hydroxypropyl hydrolyzed collagen, cocoamidopropyl hydroxysultaine, cocobetaine amidoamphopropionate, cocobetaine, cocohydroxysultaine, coco / oleamidopropyl betaine, cocosultaine, lauramidopropyl betaine, lauryl betaine, lauryl hydroxysultaine, lauryl sultaine, and mixtures thereof.

[0053] Nonionic surfactants suitable for use in the present invention include those described in McCutcheon's "Detergents and Emulsifiers" North American Edition (1986, Allured Publishing Corp.) and McCutcheon's "Functional Materials" North American Edition (1992). Nonionic surfactants suitable for use in the personal care compositions of the present invention include, but are not limited to, polyoxyethylated alkylphenols, polyoxyethylated alcohols, polyoxyethylated polypropylene glycols, glycerol alkanoates, polyglycerol alkanoates, propylene glycol alkanoates, sorbitol alkanoates, polyoxyethylated sorbitol alkanoates, polyoxyethylene glycol alkanoates, polyoxyethylated alkanoic acids, alkanolamides, N-alkyl pyrrolidones, alkyl glycosides, alkyl polyglucosides, alkyl amine oxides, and polyoxyethylated siloxanes.

[0054] The auxiliary surfactant may be a nonionic surfactant, which is selected from an alkanolamide group, including cocamide, cocamide methyl MEA, cocamide DEA, cocamide MEA, cocamide MIPA, lauramide DEA, lauramide MEA, lauramide MIPA, myristic amide DEA, myristic amide MEA, PEG-20 cocamide MEA, PEG-2 cocamide, PEG-3 cocamide, PEG-4 cocamide, PEG-5 cocamide, PEG-6 cocamide, PEG-7 cocamide, PEG-3 lauramide, PEG-5 lauramide, PEG-3 oleamide, PPG-2 cocamide, PPG-2 hydroxyethyl cocamide, PPG-2 hydroxyethyl isostearamide, and mixtures thereof.

[0055] Representative polyoxyethylated alcohols include those having alkyl chains in the C9-C16 range and having from about 1 to about 110 alkoxy groups, including but not limited to laureth-3, laureth-23, ceteth-10, steareth-10, steareth-100, beheneth-10, and those available under the trade name 91. twenty three, 25. 45. 135. 167, PC 100, PC 200, PC 600, those commercially available from Shell Chemicals (Houston, Texas), and mixtures thereof.

[0056] Also commercially available is Polyoxyethylene fatty esters are commercially available from Uniqema (Wilmington, Delaware) under the trade names HYDROGEN(R) and include, but are not limited to: 30. 35. 52. 56. 58. 72. 76. 78. 93. 97. 98. 721, and mixtures thereof.

[0057] Suitable alkyl glycosides and alkyl polyglycosides can be represented by the formula (S)nOR, wherein S is a sugar moiety such as glucose, fructose, mannose, galactose, etc.; n is an integer from about 1 to about 1000, and R is a C8-C30 alkyl group. Examples of long chain alcohols from which the alkyl group can be derived include decyl alcohol, lauryl alcohol, tetradecanol, cetyl alcohol, stearyl alcohol, oleyl alcohol, and the like. Examples of these surfactants include alkyl polyglucosides, wherein S is a glucose moiety, R is a C8-20 alkyl group, and n is an integer from about 1 to about 9. Commercially available examples of these surfactants include those sold under the trade names 325CS, 600CS and Decyl polyglucoside and lauryl polyglucoside are available from Cognis (Ambler, PA) as 625CS. Also useful herein are sucrose ester surfactants such as sucrose cocoate and sucrose laurate, and those available under the trade name Triton TMBG-10 and Triton TM CG-110 is an alkyl polyglucoside available from The Dow Chemical Company (Houston, Tx).

[0058] Other nonionic surfactants suitable for use in the present invention are glyceryl esters and polyglyceryl esters, including but not limited to glyceryl monoesters, glyceryl monoesters of C12-22 saturated, unsaturated and branched fatty acids such as glyceryl oleate, glyceryl monostearate, glyceryl monopalmitate, glyceryl monobehenate, and mixtures thereof, and polyglyceryl esters of C12-22 saturated, unsaturated and branched fatty acids such as polyglyceryl-4 isostearate, polyglyceryl-3 oleate, polyglyceryl-2-sesquioleate, diisostearate triglyceride, monooleate diglyceryl, monooleate tetraglyceryl, and mixtures thereof.

[0059] Also useful as nonionic surfactants herein are sorbitan esters. Sorbitan esters of C12-22 saturated, unsaturated and branched fatty acids can be used herein. These sorbitan esters typically comprise mixtures of monoesters, diesters, triesters, and the like. Representative examples of suitable sorbitan esters include sorbitan monolaurate ( 20), Sorbitan monopalmitate ( 40), Sorbitan monostearate ( 60), Sorbitan tristearate ( 65), Sorbitan monooleate ( 80), Sorbitan trioleate ( 85) and sorbitan isostearate.

[0060] Also suitable for use herein are alkoxylated derivatives of sorbitan esters, including but not limited to polyoxyethylene (20) sorbitan monolaurate ( 20), polyoxyethylene (20) sorbitan palmitate ( 40), polyoxyethylene (20) sorbitan monostearate ( 60), polyoxyethylene (20) sorbitan monooleate ( 80), Polyoxyethylene (4) sorbitan monolaurate ( 21) Polyoxyethylene (4) sorbitan monostearate ( 61), Polyoxyethylene (5) sorbitan monooleate ( 81), and mixtures thereof.

[0061] Also suitable for use herein are alkylphenol ethoxylates, including but not limited to nonylphenol ethoxylates (available from The Dow Chemical Company, Houston, Tx as Tergitol TM NP-4, NP-6, NP-7, NP-8, NP-9, NP-10, NP-11, NP-12, NP-13, NP-15, NP-30, NP-40, NP-50, NP-55, NP-70) and octylphenol ethoxylate (Triton from The Dow Chemical Company (Houston, Tx) TM X-15, X-35, X-45, X-114, X-100, X-102, X-165, X-305, X-405,

[0062] Also suitable for use herein are tertiary alkyl amine oxides including lauryl amine oxide and cocoamine oxide.

[0063] Non-limiting examples of other anionic surfactants, zwitterionic surfactants, amphoteric surfactants, and additional nonionic surfactants suitable for use in the hair care compositions are described in McCutcheon's "Emulsifiers and Detergents," 1989, published by MC Publishing Co., and in U.S. Pat. Nos. 3,929,678; 2,658,072; 2,438,091; 2,528,378, the entireties of which are incorporated herein by reference.

[0064] Suitable surfactant combinations have an average weight percent of alkyl branching of about 0.5% to about 30%, or about 1% to about 25%, or about 2% to about 20%. The surfactant combination may have a cumulative average weight percent of C8 to C12 alkyl chain lengths of about 7.5% to about 25%, or about 10% to about 22.5%, or about 10% to about 20%. The surfactant combination may have an average C8-C12 / C13-C18 alkyl chain ratio of about 3 to about 200, or about 25 to about 175.5, or about 50 to about 150, or about 75 to about 125.

[0065] B. Cationic polymers

[0066] The hair care composition further comprises a cationic polymer. These cationic polymers may include at least one of the following: (a) a cationic guar polymer, (b) a cationic non-guar galactomannan polymer, (c) a cationic tapioca polymer, (d) a cationic copolymer of an acrylamide monomer and a cationic monomer, and / or (e) a synthetic non-crosslinked cationic polymer that may or may not form a lyotropic liquid crystal after mixing with a detersive surfactant, (f) a cationic cellulose polymer. In addition, the cationic polymer may be a mixture of cationic polymers.

[0067] The hair care composition may comprise a cationic guar polymer which is a cationically substituted galactomannan (guar) gum derivative. The guar gum used to prepare these guar gum derivatives is generally obtained in the form of naturally occurring material obtained from the seeds of the guar gum plant. The guar gum molecule itself is a linear mannan branched at regular intervals with monosegmental galactose units on alternating mannose units. The mannose units are linked to each other via β (1-4) glycosidic linkages. Galactose branching occurs via α (1-6) bonds. Cationic derivatives of guar gum are obtained by reaction between the hydroxyl groups of the polygalactomannan with a reactive quaternary ammonium compound. The degree of substitution of the cationic groups onto the guar gum structure should be sufficient to provide the desired cationic charge density as described above.

[0068] According to one embodiment, the cationic polymer (including but not limited to cationic guar polymer) has a weight average molecular weight of less than 1,500,000 g / mol, or about 150,000 to about 1,500,000 g / mol, or about 200,000 to about 1,500,000 g / mol, or about 300,000 to about 1,200,000 g / mol, or about 750,000,000 to about 1,000,000 g / mol. In one embodiment, the cationic guar polymer has a charge density of about 0.2 to about 2.2 meq / g, or about 0.3 to about 2.0 meq / g, or about 0.4 to about 1.8 meq / g, or about 0.5 meq / g to about 1.7 meq / g.

[0069] According to one embodiment, the cationic guar polymer has a weight average molecular weight of less than about 1,500,000 g / mol and has a charge density of about 0.1 meq / g to about 2.5 meq / g. In one embodiment, the cationic guar polymer has a weight average molecular weight of less than 900,000 g / mol, or about 150,000 to about 800,000 g / mol, or about 200,000 to about 700,000 g / mol, or about 300,000 to about 700,000 g / mol, or about 400,000 to about 600,000 g / mol, about 150,000 to about 800,000 g / mol, or about 200,000 to about 700,000 g / mol, or about 300,000 to about 700,000 g / mol, or about 400,000 to about 600,000 g / mol. In one embodiment, the cationic guar polymer has a charge density of about 0.2 to about 2.2 meq / g, or about 0.3 to about 2.0 meq / g, or about 0.4 to about 1.8 meq / g, or about 0.5 meq / g to about 1.5 meq / g.

[0070] The hair care composition may comprise from about 0.05% to less than about 1%, from about 0.05% to about 0.9%, from about 0.1% to about 0.8%, or from about 0.2% to about 0.7% of the cationic polymer (a), based on the total weight of the composition.

[0071] The cationic guar polymer can be formed from a quaternary ammonium compound. In one embodiment, the quaternary ammonium compound used to form the cationic guar polymer conforms to Formula 1:

[0072]

[0073] Where R 3 , R 4 and R 5 is a methyl or ethyl group; R 6 An alkylene oxide group of the general formula 2:

[0074]

[0075] or R 6 A halohydrin group of the general formula 3:

[0076]

[0077] Where R 7 is a C1 to C3 alkylene group; X is chlorine or bromine, and Z is an anion such as Cl-, Br-, I- or HSO4-.

[0078] In one embodiment, the cationic guar polymer conforms to Formula 4:

[0079]

[0080] Where R 8 is guar gum; and wherein R 4 , R 5 , R 6 and R 7 As defined above; and wherein Z is halogen. In one embodiment, the cationic guar polymer conforms to Formula 5:

[0081]

[0082] Suitable cationic guar gum polymers include cationic guar gum derivatives such as guar hydroxypropyltrimonium chloride. In one embodiment, the cationic guar gum polymer is guar hydroxypropyltrimonium chloride. Specific examples of guar hydroxypropyltrimonium chloride include commercially available from Solvay series, such as those commercially available from Solvay C-500. C-500 has a charge density of 0.8 meq / g, and a molecular weight of 500,000 g / mol. Other suitable guar hydroxypropyltrimonium chlorides are: guar hydroxypropyltrimonium chloride having a charge density of about 1.1 meq / g and a molecular weight of about 500,000 g / mol and available from ASI, guar hydroxypropyltrimonium chloride having a charge density of about 1.5 meq / g and a molecular weight of about 500,000 g / mol and available from ASI. Other suitable guar hydroxypropyltrimonium chlorides are: Hi-Care 1000, which has a charge density of about 0.7 meq / g and a molecular weight of about 600,000 g / mole, and is available from Solvay; N-Hance 3269 and N-Hance 3270, which have a charge density of about 0.7 meq / g and a molecular weight of about 425,000 g / mol, and are available from ASI; N-Hance 3196, which has a charge density of about 0.8 meq / g and a molecular weight of about 1,100,000 g / mol, and is available from ASI. AquaCat CG518 has a charge density of about 0.9 meq / g and a molecular weight of about 50,000 g / mol, and is available from ASI. BF-13, a borate (boron) free guar gum having a charge density of about 1.1 meq / g and a molecular weight of about 800,000, and BF-17, a borate (boron) free guar gum having a charge density of about 1.7 meq / g and a M.Wt. of about 800,000, were both purchased from ASI.

[0083] The hair care composition of the present invention may comprise a galactomannan polymer derivative having a mannose to galactose ratio of greater than 2:1 on a monomer to monomer basis, the galactomannan polymer derivative being selected from a cationic galactomannan polymer derivative and an amphoteric galactomannan polymer derivative having a net positive charge. As used herein, the term "cationic galactomannan" refers to a galactomannan polymer to which a cationic group has been added. The term "amphoteric galactomannan" refers to a galactomannan polymer to which a cationic group and an anionic group have been added so that the polymer has a net positive charge.

[0084] Galactomannan polymers are present in the endosperm of leguminous seeds. Galactomannan polymers are composed of a combination of mannose monomers and galactose monomers. Galactomannan molecules are linear mannans branched with one galactose unit at regular intervals on a particular mannose unit. The mannose units are linked to each other via β (1-4) glycosidic bonds. Galactose branching is produced via α (1-6) bonds. The ratio of mannose monomers to galactose monomers may vary depending on the variety of the plant and is also affected by climate. On a monomer-to-monomer basis, the non-guar galactomannan polymer derivatives of the present invention have a mannose to galactose ratio greater than 2: 1. Suitable mannose to galactose ratios may be greater than about 3: 1, and mannose to galactose ratios may be greater than about 4: 1. Analysis of the mannose to galactose ratio is well known in the art and is typically based on measurements of galactose content.

[0085] The gums used to prepare the non-guar galactomannan polymer derivatives are generally obtained in the form of naturally occurring materials, such as seeds or bean-shaped fruits from plants. Examples of various non-guar galactomannan polymers include, but are not limited to, spiny bean gum (3 parts mannose / 1 part galactose), longifolia or carob gum (4 parts mannose / 1 part galactose), and cassia gum (5 parts mannose / 1 part galactose).

[0086] In one embodiment of the present invention, the non-guar galactomannan polymer derivative has an M.Wt. of from about 1,000 to about 10,000,000, and / or from about 5,000 to about 3,000,000.

[0087] The hair care compositions of the present invention may also include a galactomannan polymer derivative having a cationic charge density of from about 0.5 meq / g to about 7 meq / g. In one embodiment of the present invention, the galactomannan polymer derivative has a cationic charge density of from about 1 meq / g to about 5 meq / g. The degree of substitution of cationic groups onto the galactomannan structure should be sufficient to provide the desired cationic charge density.

[0088] The galactomannan polymer derivative may be a cationic derivative of a non-guar galactomannan polymer obtained by reaction between the hydroxyl groups of the polygalactomannan polymer and a reactive quaternary ammonium compound. Suitable quaternary ammonium compounds for forming cationic galactomannan polymer derivatives include those conforming to Formulas 1-5 as defined above.

[0089] The cationic non-guar galactomannan polymer derivative formed by the above reagents is represented by Formula 6:

[0090]

[0091] Wherein R is gum. The cationic galactomannan derivative may be gum hydroxypropyltrimethylammonium chloride, which may be more specifically represented by general formula 7:

[0092]

[0093] Alternatively, the galactomannan polymer derivative may be an amphoteric galactomannan polymer derivative having a net positive charge, which is obtained when the cationic galactomannan polymer derivative further comprises an anionic group.

[0094] The cationic guar galactomannan may have a mannose to galactose ratio of greater than about 4:1, a molecular weight of about 1,000 g / mol to about 10,000,000 g / mol, and / or about 50,000 g / mol to about 1,000,000 g / mol, and / or about 100,000 g / mol to about 900,000 g / mol, and / or about 150,000 g / mol to about 400,000 g / mol, and a cationic charge density of about 1 meq / g to about 5 meq / g, and / or 2 meq / g to about 4 meq / g, and may be derived from a cassia plant.

[0095] The hair care composition may comprise at least about 0.05%, by weight of the composition, of a galactomannan polymer derivative, or from about 0.05% to about 2%, by weight of the composition, of a galactomannan polymer derivative.

[0096] The hair care composition may include a water-soluble cationically modified starch polymer. As used herein, the term "cationically modified starch" refers to a starch to which cationic groups are added before the starch is degraded to have a smaller molecular weight, or to which cationic groups are added after the starch is modified to obtain a suitable molecular weight. The definition of the term "cationically modified starch" also includes amphiphilically modified starches. The term "amphiphilically modified starch" refers to a starch hydrolyzate to which cationic groups and anionic groups are added.

[0097] The hair care compositions may comprise a cationically modified starch polymer in the range of from about 0.01% to about 10%, and / or from about 0.05% to about 5%, by weight of the composition.

[0098] The cationically modified starch polymers disclosed herein have a bound nitrogen percentage of about 0.5% to about 4%.

[0099] The cationically modified starch polymer used in the hair care composition can have a molecular weight of from about 850,000 g / mol to about 1,500,000 g / mol, and / or from about 900,000 g / mol to about 1,500,000 g / mol.

[0100] The hair care composition may include a cationic modified starch polymer having a charge density of from about 0.2 meq / g to about 5 meq / g, and / or from about 0.2 meq / g to about 2 meq / g. Chemical modifications to obtain such charge density include, but are not limited to, the addition of amino and / or ammonium groups to the starch molecule. Non-limiting examples of these ammonium groups may include substituents such as hydroxypropyltrimethylammonium chloride, trimethylhydroxypropylammonium chloride, dimethylstearylhydroxypropylammonium chloride, and dimethyldodecylhydroxypropylammonium chloride. See Solarek, DB's Cationic Starches in Modified Starches: Properties and Uses (Wurzburg, OB ed., CRC Press, Inc., Boca Raton, Fla. 1986, pp. 113-125). The cationic group may be added to the starch before the starch is degraded to have a relatively small molecular weight, or the cationic group may be added thereto after the above-mentioned modification.

[0101] The cationically modified starch polymers typically have a degree of substitution of cationic groups of from about 0.2 to about 2.5. As used herein, the "degree of substitution" of a cationically modified starch polymer is an average measure of the number of hydroxyl groups on each anhydroglucose unit derived from the substituents. Since each anhydroglucose unit has three hydroxyl groups that can be substituted, the maximum possible degree of substitution is 3. On a molar average basis, the degree of substitution is expressed as the number of moles of substituents per mole of anhydroglucose unit. The degree of substitution can be determined using proton nuclear magnetic resonance spectroscopy (".sup.1H NMR") methods well known in the art. Suitable sup.1H NMR techniques include those described in: "Observation on NMR Spectra of Starches in Dimethyl Sulfoxide, Iodine-Complexing, and Solvating in Water-Dimethyl Sulfoxide" (Qin-Ji Peng and Arthur S. Perlin, "Carbohydrate Research", 160 (1987), pp. 57-72); and "An Approach to the Structural Analysis of Oligosaccharides by NMR Spectroscopy" (J. Howard Bradbury and J. Grant Collins, "Carbohydrate Research", 71, (1979), pp. 15-25.

[0102] The source of starch before chemical modification can be selected from a variety of sources, such as tubers, beans, cereals and grains. Non-limiting examples of this source starch can include corn starch, wheat starch, rice starch, waxy corn starch, oat starch, tapioca starch, waxy barley starch, waxy rice starch, glutinous rice starch, glutinous corn starch, potato starch, tapioca starch, oat starch, sago starch, glutinous rice starch, or mixtures thereof.

[0103] The cationically modified starch polymer may be selected from degraded cationic corn starch, cationic tapioca, cationic potato starch, and mixtures thereof. Alternatively, the cationically modified starch polymer is cationic corn starch and cationic tapioca.

[0104] Before degradation to have a smaller molecular weight or after modification to have a smaller molecular weight, the starch may include one or more additional modifications. For example, these modifications may include cross-linking, stabilization reactions, phosphorylation and hydrolysis. Stability reactions may include alkylation and esterification.

[0105] The cationic modified starch polymer can be incorporated into the composition in the form of hydrolyzed starch (e.g., acid, enzyme or alkaline degradation), oxidized starch (e.g., peroxide, peracid, hypochlorite, alkali or any other oxidizing agent), physically / mechanically reduced starch (e.g., via thermomechanical energy input to processing equipment), or a combination thereof.

[0106] The best form of starch is one that dissolves readily in water and forms a substantially clear (about 80% transmittance at 600 nm) solution in water. The transparency of the composition can be determined by ultraviolet / visible (UV / VIS) spectrophotometry, using a Gretag Macbeth Colorimeter Color i 5 in accordance with the relevant instructions, to measure the absorption or transmission of UV / VIS light by the sample. It has been shown that a wavelength of light of 600 nm is sufficient to characterize the transparency of a cosmetic composition.

[0107] Suitable cationically modified starches for use in hair care compositions are available from known starch suppliers. Also suitable for use in hair care compositions are nonionically modified starches, which can be further derivatized to form cationically modified starches, as is known in the art. Other suitable modified starch materials can be quaternized, as is known in the art, to produce cationically modified starch polymers suitable for use in hair care compositions.

[0108] Starch degradation process: A starch slurry can be prepared by mixing granular starch in water. The temperature is raised to about 35°C. Then, an aqueous potassium permanganate solution of about 50 ppm concentration based on starch is added. The pH is raised to about 11.5 with sodium hydroxide, and the slurry is stirred well to prevent starch precipitation. Then, a hydrogen peroxide solution of about 30% diluted in water is added to a peroxide content of about 1% based on starch. The pH is then restored to about 11.5 by adding additional sodium hydroxide. The reaction is completed within a period of about 1 to about 20 hours. The mixture is then neutralized with dilute hydrochloric acid. The degraded starch is recovered by washing, filtering and drying.

[0109] The hair care composition may include a cationic copolymer of an acrylamide monomer and a cationic monomer, wherein the copolymer has a charge density of from about 1.0 meq / g to about 3.0 meq / g. The cationic copolymer may be a synthetic cationic copolymer of an acrylamide monomer and a cationic monomer.

[0110] The cationic copolymer may comprise:

[0111] (i) an acrylamide monomer of the following formula AM:

[0112]

[0113] Where R 9H or C 1-4 alkyl; and R 10 and R 11 Independently selected from H, C 1-4 Alkyl, CH2OCH3, CH2OCH2CH(CH3)2 and phenyl, or together with C 3-6 Cycloalkyl; and

[0114] (ii) a cationic monomer conforming to formula CM:

[0115]

[0116] wherein k=1, each of v, v' and v" is independently an integer from 1 to 6, w is zero or an integer from 1 to 10, and X - It is an anion.

[0117] The cationic monomer may conform to the formula CM, and wherein k=1, v=3 and w=0, z=1, and X - Cl - , to form the following structure:

[0118]

[0119] The above structure may be referred to as a diquaternary ammonium salt. Alternatively, the cationic monomer may conform to the formula CM, and wherein v and v" are each 3, v' = 1, w = 1, y = 1, and X - Cl - ,like:

[0120]

[0121] The above structure can be called a triquaternary ammonium salt.

[0122] Suitable acrylamide monomers include, but are not limited to, acrylamide or methacrylamide.

[0123] The cationic copolymer (b) may be AM:TRIQUAT, which is a copolymer of acrylamide and N-[2-[[[dimethyl[3-[(2-methyl-1-oxo-2-propenyl)amino]propyl]ammonio]acetyl]amino]ethyl]2-hydroxy-N,N,N',N',N'-pentamethyl-1,3-propanediammonium trichloride. AM:TRIQUAT is also known as polyquaternium 76 (PQ76). AM:TRIQUAT may have a charge density of 1.6 meq / g and a molecular weight of 1,100,000 g / mol.

[0124] In an alternative embodiment, the cationic copolymer has an acrylamide monomer and a cationic monomer, wherein the cationic monomer is selected from: dimethylaminoethyl (meth)acrylate, dimethylaminopropyl (meth)acrylate, di-tert-butylaminoethyl (meth)acrylate, dimethylaminomethyl (meth)acrylamide, dimethylaminopropyl (meth)acrylamide; ethyleneimine, vinylamine, 2-vinylpyridine, 4-vinylpyridine; trimethyl (meth)acryloyloxyethylammonium chloride, trimethyl (meth)acryloyloxyethylammonium methyl sulfate, dimethylammonium (meth)acryloyloxyethylbenzylammonium chloride, 4-benzoylbenzyldimethylacryloyloxyethylammonium chloride, trimethyl (meth)acryloylaminoethylammonium chloride, trimethyl (meth)acryloylaminopropylammonium chloride, vinylbenzyltrimethylammonium chloride, diallyldimethylammonium chloride, and mixtures thereof.

[0125] The cationic copolymer may include a cationic monomer selected from the group consisting of trimethyl(meth)acryloyloxyethylammonium chloride, trimethyl(meth)acryloyloxyethylammonium methyl sulfate, dimethylammonium(meth)acryloyloxyethylbenzylammonium chloride, 4-benzoylbenzyldimethylacryloyloxyethylammonium chloride, trimethyl(meth)acrylamidoethylammonium chloride, trimethyl(meth)acrylamidopropylammonium chloride, vinylbenzyltrimethylammonium chloride, and mixtures thereof.

[0126] The cationic copolymer may be water-soluble. The cationic copolymer is formed by: (1) a copolymer of (meth)acrylamide and a cationic monomer based on (meth)acrylamide and / or a hydrolytically stable cationic monomer, (2) a terpolymer of (meth)acrylamide, a cationic (meth)acrylate-based monomer, and a (meth)acrylamide-based monomer, and / or a hydrolytically stable cationic monomer. The cationic (meth)acrylate-based monomer may be a cationized ester of (meth)acrylic acid containing a quaternized N atom. In one embodiment, the cationized ester of (meth)acrylic acid containing a quaternized N atom is a quaternized dialkylaminoalkyl (meth)acrylate having C1-C3 in the alkyl and alkylene groups. Suitable cationized esters of (meth)acrylic acid containing quaternized N atoms may be selected from the ammonium salts of dimethylaminomethyl (meth)acrylate quaternized with methyl chloride, the ammonium salts of dimethylaminoethyl (meth)acrylate, the ammonium salts of dimethylaminopropyl (meth)acrylate, the ammonium salts of diethylaminomethyl (meth)acrylate, the ammonium salts of diethylaminoethyl (meth)acrylate; and the ammonium salts of diethylaminopropyl (meth)acrylate. In one embodiment, the cationized ester of (meth)acrylic acid containing quaternized N atoms is dimethylaminoethyl acrylate, which is quaternized with an alkyl halide, or quaternized with methyl chloride or benzyl chloride or dimethyl sulfate (ADAME-Quat). When based on (meth)acrylamide, the cationic monomer may be a quaternized dialkylaminoalkyl (meth)acrylamide having C1 to C3 in the alkyl and alkylene groups, or a dimethylaminopropyl acrylamide quaternized with an alkyl halide or methyl chloride or benzyl chloride or dimethyl sulfate.

[0127] Suitable cationic monomers based on (meth)acrylamide include quaternized dialkylaminoalkyl (meth)acrylamide with C1-C3 in the alkyl and alkylene groups. The cationic monomer based on (meth)acrylamide may be dimethylaminopropylacrylamide, which is quaternized with an alkyl halide (especially methyl chloride) or benzyl chloride or dimethyl sulfate.

[0128] The cationic monomer may be a hydrolytically stable cationic monomer. In addition to dialkylaminoalkyl (meth) acrylamide, the hydrolytically stable cationic monomer may also be all monomers considered stable by the OECD hydrolysis test. The cationic monomer may be hydrolytically stable, and the hydrolytically stable cationic monomer may be selected from: diallyldimethylammonium chloride and water-soluble cationic styrene derivatives.

[0129] The cationic copolymer may be a terpolymer of acrylamide, 2-dimethylammoniumethyl (meth)acrylate quaternized with methyl chloride (ADAME-Q), and 3-dimethylammoniumpropyl (meth)acrylamide (DIMAPA-Q) quaternized with methyl chloride. The cationic copolymer may be formed from acrylamide and acrylamidopropyltrimethylammonium chloride, wherein the acrylamidopropyltrimethylammonium chloride has a charge density of about 1.0 meq / g to about 3.0 meq / g.

[0130] The cationic copolymer may have a charge density of about 1.1 meq / g to about 2.5 meq / g, or about 1.1 meq / g to about 2.3 meq / g, or about 1.2 meq / g to about 2.2 meq / g, or about 1.2 meq / g to about 2.1 meq / g, or about 1.3 meq / g to about 2.0 meq / g, or about 1.3 meq / g to about 1.9 meq / g.

[0131] The cationic copolymer can have a molecular weight of about 100,000 g / mol to about 1,500,000 g / mol, or about 300,000 g / mol to about 1,500,000 g / mol, or about 500,000 g / mol to about 1,500,000 g / mol, or about 700,000 g / mol to about 1,000,000 g / mol, or about 900,000 g / mol to about 1,200,000 g / mol.

[0132] The cationic copolymer may be trimethylaminopropyl methacrylamide chloride-N-acrylamide copolymer, which is also referred to as AM:MAPTAC. AM:MAPTAC may have a charge density of about 1.3 meq / g and a molecular weight of about 1,100,000 g / mol. The cationic copolymer may be AM:ATPAC. AM:ATPAC may have a charge density of about 1.8 meq / g and a molecular weight of about 1,100,000 g / mol.

[0133] (a) Cationic synthetic polymers

[0134] The hair care composition may comprise a cationic synthetic polymer which may be formed from:

[0135] i) one or more cationic monomer units, and optionally

[0136] ii) one or more negatively charged monomer units, and / or

[0137] iii) nonionic monomers,

[0138] The subsequent charge of the copolymer is positive. The ratios of the three types of monomers are given as "m", "p" and "q", where "m" is the number of cationic monomers, "p" is the number of negatively charged monomers and "q" is the number of nonionic monomers.

[0139] The cationic polymer may be a water-soluble or water-dispersible non-crosslinked and synthetic cationic polymer having the following structure:

[0140]

[0141] Wherein A can be one or more of the following cationic moieties:

[0142]

[0143] Wherein @ = amide, alkylamide, ester, ether, alkyl, or alkylaryl;

[0144] Wherein Y=C1-C22 alkyl, alkoxy, alkylidene, alkyl or aryloxy;

[0145] Wherein ψ=C1-C22 alkyl, alkoxy, alkylaryl or alkylaryloxy;

[0146] Wherein Z=C1-C22 alkyl, alkoxy, aryl or aryloxy;

[0147] Wherein R1=H, C1-C4 straight chain or branched alkyl;

[0148] Where s = 0 or 1, n = 0 or ≥ 1;

[0149] wherein T and R7 = C1-C22 alkyl; and

[0150] wherein X-=halogen, hydroxide, alkanolate, sulfate or alkylsulfate.

[0151] The negatively charged monomer is defined as follows: R2'=H, C1-C4 straight or branched chain alkyl, and R3 is:

[0152]

[0153] Where D=O, N, or S;

[0154] Where Q = NH2 or O;

[0155] Where u = 1-6;

[0156] where t = 0-1; and

[0157] Wherein J = an oxidized functional group containing the following elements P, S, C.

[0158] The nonionic monomer is defined as follows: R2" = H, C1-C4 straight or branched alkyl, R6 = straight or branched alkyl, alkylaryl, aryloxy, alkoxy, alkylaryloxy, and β is defined as

[0159] as well as

[0160] wherein G′ and G″ are independently O, S or NH, and L=0 or 1.

[0161] Examples of cationic monomers include aminoalkyl (meth)acrylates, (meth)aminoalkyl (meth)acrylamides; monomers containing at least one secondary amine, tertiary amine or quaternary ammonium functional group, or a heterocyclic group containing a nitrogen atom, vinylamine or ethyleneimine; diallyldialkylammonium salts; mixtures thereof, salts thereof, and macromonomers derived therefrom.

[0162] Other examples of cationic monomers include dimethylaminoethyl (meth)acrylate, dimethylaminopropyl (meth)acrylate, di-tert-butylaminoethyl (meth)acrylate, dimethylaminomethyl (meth)acrylamide, dimethylaminopropyl (meth)acrylamide, ethyleneimine, vinylamine, 2-vinylpyridine, 4-vinylpyridine, (meth)acryloyloxyethyltrimethylammonium chloride, (meth)acryloyloxyethyltrimethylammonium methylsulfate, (meth)acryloyloxyethylbenzyldimethylammonium chloride, 4-benzoylbenzylacryloyloxyethyldimethylammonium chloride, (meth)acrylamidoethyltrimethylammonium chloride, (meth)acrylamidopropyltrimethylammonium chloride, vinylbenzyltrimethylammonium chloride, and diallyldimethylammonium chloride.

[0163] Suitable cationic monomers include those comprising the formula -NR3 + Those of quaternary ammonium groups, wherein R is the same or different, represents a hydrogen atom, an alkyl group containing 1 to 10 carbon atoms, or a benzyl group, optionally with a hydroxyl group, and contains an anion (counter ion). Examples of anions are halides (such as chloride, bromide), sulfate, hydrogen sulfate, alkyl sulfate (e.g. containing 1 to 6 carbon atoms), phosphate, citrate, formate and acetate.

[0164] Suitable cationic monomers include (meth)acryloyloxyethyltrimethylammonium chloride, (meth)acryloyloxyethyltrimethylammonium methylsulfate, (meth)acryloyloxyethylbenzyldimethylammonium chloride, 4-benzoylbenzylacryloyloxyethyldimethylammonium chloride, (meth)acrylamidoethyltrimethylammonium chloride, (meth)acrylamidopropyltrimethylammonium chloride, and vinylbenzyltrimethylammonium chloride.

[0165] Other suitable cationic monomers include propyl (meth)acrylamidotrimethylammonium chloride.

[0166] Examples of monomers having a negative charge include α-ethylenically unsaturated monomers containing a phosphate or phosphonate group, α-ethylenically unsaturated monocarboxylic acids, monoalkyl esters of α-ethylenically unsaturated dicarboxylic acids, monoalkyl amides of α-ethylenically unsaturated dicarboxylic acids, α-ethylenically unsaturated compounds containing a sulfonic acid group, and salts of α-ethylenically unsaturated compounds containing a sulfonic acid group.

[0167] Suitable monomers having a negative charge include acrylic acid, methacrylic acid, vinyl sulfonic acid, salts of vinyl sulfonic acid, vinylbenzenesulfonic acid, salts of vinylbenzenesulfonic acid, α-acrylamidomethylpropanesulfonic acid, salts of α-acrylamidomethylpropanesulfonic acid, 2-sulfoethyl methacrylate, salts of 2-sulfoethyl methacrylate, acrylamide-2-methylpropanesulfonic acid (AMPS), salts of acrylamide-2-methylpropanesulfonic acid, and styrene sulfonate (SS).

[0168] Examples of nonionic monomers include vinyl acetate, amides of α-ethylenically unsaturated carboxylic acids, esters of α-ethylenically unsaturated monocarboxylic acids with hydrogenated or fluorinated alcohols, polyethylene oxide (meth)acrylates (i.e., with polyethoxylated (meth)acrylic acid), monoalkyl esters of α-ethylenically unsaturated dicarboxylic acids, monoalkyl amides of α-ethylenically unsaturated dicarboxylic acids, vinyl nitriles, vinylamine amides, vinyl alcohol, vinyl pyrrolidone, and vinyl aromatic compounds.

[0169] Suitable nonionic monomers include styrene, acrylamide, methacrylamide, acrylonitrile, methyl acrylate, ethyl acrylate, n-propyl acrylate, n-butyl acrylate, methyl methacrylate, ethyl methacrylate, n-propyl methacrylate, n-butyl methacrylate, 2-ethylhexyl acrylate, 2-ethylhexyl methacrylate, 2-hydroxyethyl acrylate, and 2-hydroxyethyl methacrylate.

[0170] The anionic counterion (X-) associated with the synthetic cationic polymer can be any known counterion, so long as the polymer remains dissolved or dispersed in water, in the hair care composition, or in a coacervate phase in the hair care composition, and so long as the counterion is physically and chemically compatible with the essential components of the hair care composition, or does not otherwise unduly impair product performance, stability, or aesthetics. Non-limiting examples of such counterions include halides (e.g., chloride, fluoride, bromide, iodide), sulfate, and methylsulfate.

[0171] The cationic polymers described herein can help provide a replacement hydrophobic F-layer to damaged hair, especially chemically treated hair. The extremely thin F-layer provides natural weather resistance while helping to seal in moisture and prevent further damage. Chemical treatments damage the hair cuticle and strip its protective F-layer. As the F-layer is stripped, the hair becomes increasingly hydrophilic. It has been found that when lyotropic liquid crystals are applied to chemically treated hair, the hair becomes more hydrophobic and more natural in both appearance and feel. Without being bound by any theory, it is believed that the lyotropic liquid crystal complex forms a hydrophobic layer or film that covers the hair fiber and protects the hair, just as the natural F-layer protects the hair. The hydrophobic layer restores the hair to a generally untreated, healthier state. The lyotropic liquid crystals are formed by mixing the synthetic cationic polymers described herein with the anionic detersive surfactant component of the aforementioned hair care composition. The synthetic cationic polymers have a relatively high charge density. It should be noted that some synthetic polymers with relatively high cationic charge density do not form lyotropic liquid crystals, primarily due to their abnormal linear charge density. Such synthetic cationic polymers are described in WO 94 / 06403 to Reich et al. The synthetic polymers described herein can be formulated into stable hair care compositions that provide improved conditioning properties for damaged hair.

[0172] The cationic synthetic polymer that can form lyotropic liquid crystals has a cationic charge density of about 2 meq / gm to about 7 meq / gm, and / or about 3 meq / gm to about 7 meq / gm, and / or about 4 meq / gm to about 7 meq / gm. In some embodiments, the cationic charge density is about 6.2 meq / gm. The polymer also has an M.Wt. of about 1,000 to about 5,000,000, and / or about 10,000 to about 1,500,000, and / or about 100,000 to about 1,500,000.

[0173] In another embodiment of the present invention, the cationic synthetic polymer that provides enhanced conditioning and benefit agent deposition without forming lyotropic liquid crystals has a cationic charge density of from about 0.7 meq / gm to about 7 meq / gm, and / or from about 0.8 meq / gm to about 5 meq / gm, and / or from about 1.0 meq / gm to about 3 meq / gm. The polymer also has a M.Wt. of from about 1,000 to about 1,500,000, from about 10,000 to about 1,500,000, and from about 100,000 to about 1,500,000.

[0174] Suitable cationic cellulose polymers are salts of hydroxyethylcellulose reacted with trimethylammonium substituted epoxides, known in the industry (CTFA) as polyquaternium 10, and available from Dow / Amerchol Corp. (Edison, NJ, USA) in their Polymer LR, JR and KG polymer series. Non-limiting examples include: JR-30M, KG-30M, JP, LR-400, and mixtures thereof. Other suitable types of cationic cellulose include polymeric quaternary ammonium salts generated by the reaction of hydroxyethylcellulose with lauryl dimethyl ammonium substituted epoxides, known in the industry (CTFA) as polyquaternium 24. These materials can be purchased from Dow / Amerchol Corp. under the trade name Polymer LM-200. Other suitable types of cationic cellulose include polymeric quaternary ammonium salts obtained by the reaction of hydroxyethylcellulose with lauryl dimethyl ammonium substituted epoxides and trimethyl ammonium substituted epoxides, known in the industry (CTFA) as polyquaternium 67. These materials are available from Dow / Amerchol Corp. under the trade designations SoftCAT Polymer SL-5, SoftCAT Polymer SL-30, Polymer SL-60, Polymer SL-100, Polymer SK-L, Polymer SK-M, Polymer SK-MH, and Polymer SK-H.

[0175] Concentrations of the cationic polymer range from about 0.025% to about 5%, from about 0.1% to about 3%, and / or from about 0.2% to about 1%, by weight of the hair care composition.

[0176] C. Viscosity reducer

[0177] In one embodiment, the hair care compositions described herein may contain from about 0.1% to about 35%, or from about 0.25% to about 30%, or from about 0.5% to about 25%, by weight of the hair care composition, of a viscosity reducing agent. Non-limiting examples of suitable viscosity reducing agents include Class A materials, Class B materials, water-miscible solvents, hydrotropes, and mixtures thereof.

[0178] The hair care compositions described herein can have a liquid phase viscosity of from about 1 centipoise to about 6,000 centipoise, or from about 1 centipoise to about 4,500 centipoise, or from about 1 centipoise to about 3,000 centipoise, or from about 5 centipoise to about 2,000 centipoise.

[0179] 1. Class A viscosity reducer

[0180] The Class A viscosity reducer may have a distribution diffusion coefficient of about -3.1 to about -0.7, or about -3 to about -0.85, or about -2.92 to about -0.92. The Class A viscosity reducer may have a distribution diffusion coefficient of about -3 to about -1.9, or about -2.9 to about -2, wherein the one or more viscosity reducers have at least 2 polar groups, or have 1 polar group, and less than 5 acyclic sp groups connected to each other in adjacent groups. 3 The Class A viscosity reducer may have a distribution diffusion coefficient of about -3 to about -1.9, or about -2.9 to about -2, wherein the one or more viscosity reducers have 2 to 4 polar groups, or have 1 polar group and 1 to 3 acyclic sp groups connected to each other in adjacent groups. 3 The Class A viscosity reducer may have a distribution diffusion coefficient of about -3 to about -1, or about -2.9 to about -2, wherein the one or more viscosity reducers have 2 to 4 polar groups, or have 1 polar group and 2 acyclic sp groups connected to each other in adjacent groups. 3 Hybridized carbon atoms. When used in the hair care compositions described herein, the Class A viscosity reducing agents can provide unexpected viscosity reduction.

[0181] The partition diffusion coefficient (PDC) is defined by the following formula:

[0182] PDC=logP-0.3001*(δD)2+10.362*δD-93.251

[0183] where logP is the octanol-water partition coefficient as calculated by the consensus algorithm implemented in ACD / Percepta Version 14.02 by Advanced Chemistry Development, Inc. (ACD / Labs, Toronto, Canada), and where δD is the Hansen solubility partition parameter in (MPa)1 / 2 calculated using the "HSPIP—Hansen Solubility Parameters in Practice" program by Steven Abbott and Hiroshi Yamamoto (Version 4, Version 4.1.07).

[0184] The viscosity reducer can be an organic compound, comprising 1 polar group, or at least 1 polar group, or 2 to 4 polar groups, alternatively or at least 2 polar groups. The polar group can be selected from alcohol, aldehyde, ester, lactone, coumarin, ether, ketone, phenol, phenyl, oxide, alkenyl, alkynyl and their combination. The viscosity reducer can have a molecular weight between 100 daltons and 300 daltons, or about 125 daltons to about 300 daltons. In addition, between 23 and 25 degrees Celsius, the viscosity reducer can have a solubility in the water of about 900 to 50,000 mg / L.

[0185] The viscosity reducing agent can be selected from raspberry ketone, triethyl citrate, 5-methyl-3-heptanone oxime, hydroxycitronellal, camphor gum, 2-isopropyl-5-methyl-2-hexenal, eucalyptol, 1,1-dimethoxyoctane, isobutyl hexanoate, methyl dihydroisojasmonate, and combinations thereof. Alternatively, the viscosity reducing agent can be selected from raspberry ketone, triethyl citrate, hydroxycitronellal, camphor gum, and combinations thereof. Alternatively, the viscosity reducing agent can be selected from raspberry ketone, triethyl citrate, hydroxycitronellal, camphor gum, and combinations thereof.

[0186] 2. Type B viscosity reducer

[0187] The type B viscosity reducing agent can have a partition diffusion coefficient of from about 0.05 to about 5.1, or from about 0.08 to about 4.5, or from about 0.09 to about 4.4, or from about 0.05 to about 2.0, or from about 0.08 to about 1.8, or from about 0.09 to about 1.7, or from about 0.095 to about 1.68. When used in the hair care compositions described herein, the type B viscosity reducing agent can provide unexpected viscosity reduction.

[0188] The partition diffusion coefficient (PDC) is defined by the following formula:

[0189] PDC=logP-0.3001*(δD) 2 +10.362*δD-93.251

[0190] where logP is the octanol-water partition coefficient as calculated by the consensus algorithm implemented in ACD / Percepta Version 14.02 by Advanced Chemistry Development, Inc. (ACD / Labs, Toronto, Canada), and where δD is the pressure in MPa (MPa) calculated using the "HSPIP-Hansen Solubility Parameters in Practice" program by Steven Abbott and Hiroshi Yamamoto (Version 4, Version 4.1.07). 1 / 2The Hansen solubility assignment parameter is in units.

[0191] Described viscosity reducer can be organic compound, comprises 1 polar group, or at least 1 polar group, or 2 to 4 polar groups, alternatively or at least 2 polar groups.Described polar group can be selected from alcohol, aldehyde, ester, lactone, coumarin, ether, ketone, phenol, phenyl, oxide, alkenyl, alkynyl and their combination.Described viscosity reducer can have between 100 dalton and 300 dalton, or about 125 dalton to about 300 dalton molecular weight.In addition, between 23 and 25 degrees Celsius, described viscosity reducer can have solubility in the water of about 10 to 900mg / L.

[0192] The B-type viscosity reducer can be selected from shikonone, isoamyl salicylate, γ-terpinene, linalyl isobutyrate, α-terpinene, limonene, dipentene, geranyl phenylacetate, isopropyl myristate, hexadecane, and combinations thereof. Alternatively, the B-type viscosity reducer can be selected from shikonone, γ-terpinene, linalyl isobutyrate, α-terpinene, limonene, dipentene, geranyl phenylacetate, isopropyl myristate, hexadecane, and combinations thereof. Alternatively, the B-type viscosity reducer can be selected from shikonone, isoamyl salicylate, γ-terpinene, linalyl isobutyrate, α-terpinene, limonene, dipentene, geranyl phenylacetate, and combinations thereof.

[0193] 3. Water-miscible solvents

[0194] Carriers useful in embodiments of the hair care composition include water and aqueous solutions of lower alkyl alcohols, polyols, ketones having 3 to 4 carbon atoms, C1-C6 esters of C1-C6 alcohols, sulfoxides, amides, carbonates, ethoxylated and propoxylated C1-C10 alcohols, lactones, pyrrolidones, and mixtures thereof. Non-limiting examples of lower alkyl alcohols are monohydric alcohols having 1 to 6 carbon atoms, such as ethanol and isopropanol. Non-limiting examples of polyols useful herein include propylene glycol, dipropylene glycol, butylene glycol, hexylene glycol, glycerol, propane diol, and mixtures thereof.

[0195] In one embodiment of the present invention, the hair care composition may comprise a hydrotrope / viscosity modifier which is an alkali metal or ammonium lower alkylbenzene sulfonate, such as sodium xylene sulfonate, sodium cumene sulfonate, or sodium toluene sulfonate.

[0196] In another embodiment of the present invention, the hair care composition may include silicone / PEG-8 silicone / PEG-9 silicone / PEG-n silicone / silicone ether (n may be another integer), non-limiting examples of which include PEG8-polydimethylsiloxane A208) MW 855, PEG 8 polydimethylsiloxane D208 MW 2706.

[0197] D. Propellant or foaming agent

[0198] The concentrated hair care compositions described herein may comprise from about 1% to about 10% of a propellant or foaming agent, or from about 2% to about 8% of a propellant, by weight of the concentrated hair care composition.

[0199] The propellant or foaming agent may comprise one or more volatile materials which are in a gaseous state and may carry other components of the concentrated hair care composition in the form of particles or droplets or as a foam. The propellant or foaming agent may have a boiling point in the range of about -45°C to about 5°C. When packaged under pressure in a conventional aerosol container, the propellant or foaming agent may be liquefied. After leaving the aerosol foam dispenser, the boiling of the propellant or foaming agent may help to atomize or foam the other components of the concentrated hair care composition.

[0200] Aerosol propellants or blowing agents that can be used in the aerosol composition may include chemically inert hydrocarbons such as propane, n-butane, isobutane, cyclopropane, and mixtures thereof, and halogenated hydrocarbons such as dichlorodifluoromethane, 1,1-dichloro-1,1,2,2-tetrafluoroethane, 1-chloro-1,1-difluoro-2,2-trifluoroethane, 1-chloro-1,1-difluoroethylene, 1,1-difluoroethane, dimethyl ether, monochlorodifluoromethane, trans-1,3,3,3-tetrafluoropropene, and mixtures thereof. The propellant or blowing agent may include hydrocarbons such as isobutane, propane, and butane—these materials may be used for their low ozone reactivity and may be used as separate components, wherein their vapor pressure at 21.1° C. is in the range of about 1.17 bar to about 7.45 bar, or about 1.17 bar to about 4.83 bar, or about 2.14 bar to about 3.79 bar.

[0201] E. Scalp health agent

[0202] In one embodiment of the present invention, one or more scalp health agents may be added to provide scalp benefits in addition to the antifungal / anti-dandruff effects provided by the surfactant soluble anti-dandruff agents. Such materials are varied and provide a variety of benefits including moisturizing, barrier improvement, antifungal, antimicrobial and antioxidant, anti-itch, and sensitization, as well as additional anti-dandruff agents such as zinc pyrithione (ZPT) or selenium sulfide. Such scalp health agents include, but are not limited to: vitamins E and F, salicylic acid, niacinamide, caffeine, panthenol, zinc oxide, zinc carbonate, glycols, glycolic acid, PCA, PEG, erythritol, glycerin, triclosan, lactate, hyaluronate, allantoin and other ureas, betaine, sorbitol, glutamate, xylitol, menthol, menthyl lactate, isoambroxan, benzyl alcohol, compounds containing the following structure:

[0203]

[0204] R1 is selected from H, alkyl, aminoalkyl, alkoxy;

[0205] Q=H2, O, -OR1, -N(R1)2, -OPO(OR1) x 、-PO(OR1) x 、-P(OR1) x , where x = 1-2;

[0206] V=NR1、O、-OPO(OR1) x 、-PO(OR1) x 、-P(OR1) x , where x = 1-2;

[0207] W=H2、O;

[0208] X, Y = independently selected from H, aryl, naphthyl (for n = 0);

[0209] X, Y = aliphatic CH2 or aromatic CH (for n ≥ 1), and Z is selected from aliphatic CH2, aromatic CH, or a heteroatom;

[0210] A = lower alkoxy, lower alkylthio, aryl, substituted aryl or condensed aryl; and

[0211] Stereochemistry may vary at the positions marked *.

[0212] and natural extracts / oils, including peppermint, spearmint, argan, jojoba, and aloe vera.

[0213] F. Optional Ingredients

[0214] According to an embodiment of the present invention, the hair care composition may further comprise one or more optional ingredients, including benefit agents. Suitable benefit agents include, but are not limited to, conditioning agents, cationic polymer silicone emulsions, anti-dandruff agents, gel networks, chelating agents, and natural oils such as sunflower oil or castor oil. Additional suitable optional ingredients include, but are not limited to, fragrances, fragrance microcapsules, colorants, particles, antimicrobial agents, foam inhibitors, antistatic agents, rheology modifiers and thickeners, suspending materials and structurants, pH adjusters and buffers, preservatives, pearlescent agents, solvents, diluents, antioxidants, vitamins, and combinations thereof.

[0215] Such optional ingredients should be physically and chemically compatible with the components of the composition and should not unduly impair product stability, aesthetics or performance. The CTFA Cosmetic Ingredient Handbook, Tenth Edition, published by the Cosmetic, Toiletry, and Fragrance Association, Inc. (Washington, DC) (2004) (hereinafter "CTFA") describes a variety of non-limiting materials that can be added to the compositions herein.

[0216] 1. Conditioning Agents

[0217] The conditioning agent of the hair care composition can be a silicone conditioning agent. The silicone conditioning agent can include volatile silicones, non-volatile silicones, or combinations thereof. The concentration of the silicone conditioning agent is typically in the range of from about 0.01% to about 10%, from about 0.1% to about 8%, from about 0.1% to about 5%, and / or from about 0.2% to about 3% by weight of the composition. Non-limiting examples of suitable silicone conditioning agents and optional silicone suspending agents are described in U.S. Reissued Patent 34,584; U.S. Pat. No. 5,104,646 and U.S. Pat. No. 5,106,609, which descriptions are incorporated herein by reference.

[0218] The silicone conditioning agent used in the present compositions may have a viscosity of about 20 to about 2,000,0000 centistokes ("csk"), about 1,000 to about 1,800,000 csk, about 10,000 to about 1,500,000 csk, and / or about 20,000 to about 1,500,000 csk as measured at 25°C.

[0219] The dispersed silicone conditioning agent particles typically have a volume average particle size in the range of about 0.01 microns to about 60 microns. For small particles applied to the hair, the volume average particle size is typically in the range of about 0.01 microns to about 4 microns, about 0.01 microns to about 2 microns, about 0.01 microns to about 0.5 microns.

[0220] Additional information on silicones, including sections discussing silicone fluids, silicone gums, and silicone resins, and silicone preparation, can be found in Encyclopedia of Polymer Science and Engineering, Vol. 15, 2nd Edition, pp. 204-308, John Wiley & Sons, Inc. (1989), which is incorporated herein by reference.

[0221] Suitable silicone emulsions for use in embodiments of the present invention include, but are not limited to, insoluble polysiloxane emulsions prepared according to the descriptions provided in U.S. Pat. No. 6,316,541 or U.S. Pat. No. 4,476,282 or U.S. Patent Application Publication No. 2007 / 0276087. Thus, suitable insoluble polysiloxanes include polysiloxanes having an internal phase viscosity of from about 5 csk to about 500,000 csk, such as α,ω-hydroxyl-terminated polysiloxanes or α,ω-alkoxy-terminated polysiloxanes. For example, the insoluble polysiloxane may have an internal phase viscosity of less than 400,000 csk, preferably less than 200,000 csk, more preferably from about 10,000 csk to about 180,000 csk. The insoluble polysiloxane may have an average particle size in the range of from about 10 nm to about 10 microns. The average particle size may be in the range of from about 15 nm to about 5 microns, from about 20 nm to about 1 micron, or from about 25 nm to about 500 nm.

[0222] The average molecular weight of the insoluble polysiloxane, the internal phase viscosity of the insoluble polysiloxane, the viscosity of the silicone emulsion, and the size of the particles containing the insoluble polysiloxane are determined by methods commonly used by those skilled in the art, such as the method disclosed in Smith, AL, The Analytical Chemistry of Silicones, John Wiley & Sons, Inc.: New York, 1991. For example, the viscosity of the silicone emulsion can be measured at 30° C. using a Brookfield viscometer with spindle 6 at 2.5 rpm. The silicone emulsion may further contain additional emulsifiers and anionic surfactants.

[0223] Other classes of silicones suitable for use in the compositions of the present invention include, but are not limited to: i) silicone fluids, including but not limited to silicone oils, which are flowable materials having a viscosity of less than about 1,000,000 csk as measured at 25°C; ii) amino silicones containing at least one primary, secondary or tertiary amine; iii) cationic silicones containing at least one quaternary ammonium functional group; iv) silicone gums; which include materials having a viscosity greater than or equal to 1,000,000 csk as measured at 25°C; v) silicone resins, which include highly crosslinked polymerized siloxane systems; vi) high refractive index silicones having a refractive index of at least 1.46, and vii) mixtures thereof.

[0224] The conditioning agent in the hair care composition of the present invention may also include at least one organic conditioning material such as an oil or wax, alone or in combination with other conditioning agents such as the above-mentioned silicones. The organic material may be non-polymeric, oligomeric or polymeric. It may be in the form of an oil or wax and may be added to the formulation in pure form or in pre-emulsified form. Some non-limiting examples of organic conditioning materials include, but are not limited to: i) hydrocarbon oils; ii) polyolefins, iii) fatty acid esters, iv) fluorinated conditioning compounds, v) fatty alcohols, vi) alkyl glucosides and alkyl glucoside derivatives; vii) quaternary ammonium compounds; viii) polyethylene glycols and polypropylene glycols having a molecular weight of up to about 2,000,000, including those having the CTFA designations PEG-200, PEG-400, PEG-600, PEG-1000, PEG-2M, PEG-7M, PEG-14M, PEG-45M, and mixtures thereof.

[0225] 2. Emulsifier

[0226] A variety of anionic and nonionic emulsifiers can be used in the hair care compositions of the present invention. The anionic and nonionic emulsifiers can be monomeric or polymeric in nature. For example, examples of monomers include, but are not limited to, alkyl ethoxylates, alkyl sulfates, soaps, and fatty acid esters, and their derivatives. For example, examples of polymers include, but are not limited to, polyacrylates, polyethylene glycols, and block copolymers, and their derivatives. Naturally occurring emulsifiers such as lanolin, lecithin, and lignin, and their derivatives, are also non-limiting examples of useful emulsifiers.

[0227] 3. Chelating agents

[0228] The hair care composition may also contain a chelating agent. Suitable chelating agents include those listed in Critical Stability Constants Vol. 1 by AE Martell & RR Smith (Plenum Press, New York & London, 1974) and Metal Complexes in Aqueous Solutions by AE Martell & RR Hancock (Plenum Press, New York & London, 1996), both of which are incorporated herein by reference. When referring to chelating agents, the term "their salts and derivatives" refers to salts and derivatives having the same functional structure (e.g., the same chemical backbone) as the chelating agent to which they refer and having similar or better chelating properties. The term includes alkali metal salts, alkaline earth metal salts, ammonium salts, substituted ammonium (i.e., monoethanolamine, diethanolamine, triethanolammonium) salts, esters, and mixtures thereof of chelating agents having an acidic portion, especially all sodium, potassium or ammonium salts. The term "derivative" also includes "chelating surfactant" compounds such as those exemplified in U.S. Pat. No. 5,284,972, and macromolecules containing one or more chelating groups having the same functional structure as the parent chelating agent, such as the polymer EDDS (ethylenediamine disuccinic acid) disclosed in U.S. Pat. No. 5,747,440.

[0229] The content of EDDS chelating agent in the hair care composition can be as low as about 0.01% by weight or even as high as about 10% by weight, but above higher levels (i.e., 10% by weight), formulation and / or human safety issues may arise. In one embodiment, the content of EDDS chelating agent can be at least about 0.05% by weight, at least about 0.1% by weight, at least about 0.25% by weight, at least about 0.5% by weight, at least about 1% by weight, or at least about 2% by weight based on the weight of the hair care composition. Levels above about 4% by weight can be used, but additional benefits may not be obtained.

[0230] 4. Aqueous carrier

[0231] The hair care composition may be in the form of a pourable liquid (under ambient conditions). Thus, such compositions will typically comprise a carrier in an amount from about 40% to about 85%, or from about 45% to about 80%, or from about 50% to about 75% by weight of the hair care composition. The carrier may comprise water, or a miscible mixture of water and an organic solvent, and in one aspect, may comprise water and minimal or insignificant concentrations of organic solvents, except for those otherwise incidentally incorporated into the composition as minor components of other essential or optional components.

[0232] Carriers useful in embodiments of the hair care compositions of the present invention include water and aqueous solutions of lower alkyl alcohols and polyols. The lower alkyl alcohols useful herein are monohydric alcohols having 1 to 6 carbons, in one aspect, ethanol and isopropanol. Exemplary polyols useful herein include propylene glycol, hexylene glycol, glycerol, and propane diol.

[0233] G. Foam dispenser

[0234] The hair care composition described herein may be provided in a foam dispenser. The foam dispenser may be an aerosol foam dispenser. The aerosol foam dispenser may include a reservoir for retaining the hair treatment composition. The reservoir may be made of any suitable material selected from plastics, metals, alloys, laminates, and combinations thereof. In one embodiment, the reservoir may be disposable. In one embodiment, the reservoir may be removable from the aerosol foam dispenser. Alternatively, the reservoir may be integrated with the aerosol foam dispenser. In one embodiment, two or more reservoirs may be present.

[0235] The foam dispenser may also be a mechanical foam dispenser. The mechanical foam dispenser may be selected from a squeeze foam dispenser, a pump dispenser, other mechanical foam dispensers, and combinations thereof. In one embodiment, the mechanical foam dispenser is a squeeze foam dispenser. Non-limiting examples of suitable pump dispensers include those described in WO 2004 / 078903, WO 2004 / 078901, and WO 2005 / 078063, and may be supplied by Albea (60 Electric Ave., Thomaston, CT 06787 USA) or Rieke Packaging Systems (500 West Seventh St., Auburn, Indiana 46706).

[0236] The mechanical foam dispenser may comprise a reservoir for retaining a concentrated hair treatment composition. The reservoir may be made of any suitable material selected from plastics, metals, alloys, laminates, and combinations thereof. The reservoir may be a refillable reservoir such as an injection-type or screw-on reservoir, or the reservoir may be disposable. The reservoir may also be removable from the mechanical foam dispenser. Alternatively, the reservoir may be integrated with the mechanical foam dispenser. In one embodiment, there may be two or more reservoirs.

[0237] In one embodiment, the reservoir may be constructed of a material selected from the group consisting of a rigid material, a flexible material, and combinations thereof. The reservoir may be constructed of a rigid material if it does not collapse under external atmospheric pressure when an internal partial vacuum is applied to the reservoir.

[0238] H. Product form

[0239] The hair care compositions of the present invention may be in the form of typical hair care formulations. They may be in the form of solutions, dispersions, emulsions, powders, talc, encapsulations, spheres, sponges, solid dosage forms, foams, and other delivery mechanisms. The compositions of embodiments of the present invention may be hair tonics, leave-in hair products such as treatment and styling products, rinse-off hair products such as shampoos and personal cleansing products, and treatment products; and any other form that may be applied to hair.

[0240] I. Application Device

[0241] In one embodiment of the present invention, the hair care composition can be dispensed from an applicator for direct dispensing to the scalp area. Dispensing directly onto the scalp through a targeted delivery applicator enables deposition of undiluted cleanser directly where the need for cleansing is greatest. This also minimizes the risk of eye contact with the cleansing solution.

[0242] The applicator is attached to, or can be connected to, a bottle containing a clean Prodhair care composition. The applicator can consist of a base that holds or extends to a single or multiple tines. The tines have openings that can be located at the tip, the base, or any point between the tip and the base. These openings allow the product to be dispensed directly from the bottle onto the hair and / or scalp.

[0243] Alternatively, the applicator may also consist of brush-like bristles attached or extending from a base. In this case, the product will be dispensed from the base, and the bristles will allow product dispensing to be carried out by combing or brushing motion.

[0244] The applicator and tine design and materials may also be optimized to enable scalp massage. In this case, it may be beneficial for the tine or bristle geometry to be more rounded at the tip, similar to a roller ball applicator for eye creams. Materials that are smoother and softer may also be beneficial; for example metal or metal-like finishes, "rubber materials".

[0245] Viscosity measurement

[0246] A cone-plate Brookfield RS rheometer with cone C75-1 can be used at 2 s -1 The shampoo viscosity was measured on 2.5 mL of sample at 27°C for 3 minutes.

[0247] Diffusion coefficient determination by NMR

[0248] The cleaning composition containing the surfactant-soluble agent was diluted with deionized water to a surfactant concentration of about 1.3%. It is believed that this dilution factor represents the cleaning composition when applied to the head during use. The diluted sample was introduced into a 5mm NMR tube and no further preparation was performed. There was no deuterated solvent, so all experiments were performed under unlocked field. The diffusion coefficient was determined using a Bruker Avance 700MHz NMR spectrometer equipped with a BBO z gradient probe, using a pulse sequence provided by the supplier ("ledbpgppr2s", stimulated echo of a bipolar gradient, longitudinal eddy current delay, presaturated and 2 spoiler gradients). The gradient pulse duration ranged from 3000-6000us, and the diffusion period was set to 150ms. 32 linearly spaced gradient values ​​were used, and the gradient values ​​were within the range of 2%-95% of the 10A current from the GREAT 3 / 10 amplifier, and the resulting gradient strength was given by 5Gauss / cm / A. The data was processed using the software provided by the supplier.

[0249] The surfactant micelle diffusion coefficient is expressed as D S , and the surfactant-solvent diffusion coefficient is denoted as D A The ratio of the surfactant diffusion coefficient to the surfactant-soluble reagent diffusion coefficient can be calculated using the following formula:

[0250]

[0251] Measurement of surfactant-soluble agent deposition

[0252] In vivo deposition of surfactant-soluble agents on the scalp can be measured by ethanol extraction of the agent after the scalp has been treated with a cleansing composition comprising a surfactant-soluble agent and rinsed off. The concentration of the agent in the ethanol extraction solvent is measured by HPLC. Quantification is performed by reference to a standard curve. The concentration detected by HPLC is converted to a collection amount in grams by multiplying the concentration by the volume.

[0253] The percentage of deposited reagent can be calculated using the following formula:

[0254]

[0255] The deposition efficiency can be calculated using the following formula:

[0256]

[0257] Preparation of shampoo compositions

[0258] The shampoo composition is prepared by adding the surfactant, anti-dandruff agent, fragrance, viscosity modifier, cationic polymer and the remainder of the water, stirring well to ensure a uniform mixture. The mixture may be heated to 50-75°C to accelerate dissolution of the soluble agents and then cooled. The product pH may be adjusted as necessary to provide a shampoo composition of the present invention suitable for application to human hair and scalp, and may vary based on the selection of a particular detersive surfactant and / or other components.

[0259] Non-limiting Examples

[0260] The shampoo compositions illustrated in the following examples can be prepared by conventional formulation and mixing methods. Unless otherwise specified, all exemplified amounts are listed as weight percentages, except for minor substances such as diluents, preservatives, color solutions, imaginary ingredients, botanicals, etc. Unless otherwise specified, all percentages are based on weight.

[0261]

[0262] 1 Sodium undecyl sulfate with 70% active substance, supplier: P&G

[0263] 2 Sodium Laureth-1 Sulfate with 26% active ingredients, Supplier: P&G

[0264] 3 Oxymetholone, Supplier: Clariant

[0265] 4 Sodium chloride, Supplier: Morton

[0266] Results of Examples 1-2

[0267] For Example 1, the ratio of the diffusion coefficients (D S / D A ) is close to 1.0, which indicates that octopirox olamine diffuses at the same rate as the SLE1S micelles, meaning that octopirox olamine is within the SLE1S micelles. S / D A ) is significantly greater than 1.0, which indicates that octopirox olamine diffuses at a different rate from the sodium undecyl sulfate micelle, meaning that octopirox olamine is not within the sodium undecyl sulfate micelle. The significance of octopirox olamine not being within the surfactant micelle in Example 2 is reflected in the substantial increase in the deposition efficiency of Example 2, which is 3.6 times that of Example 1 (control).

[0268]

[0269] 1 Sodium Laureth-1 Sulfate with 26% active ingredients, Supplier: P&G

[0270] 2 Oxymetholone, Supplier: Clariant

[0271] 3 Sodium chloride, Supplier: Morton

[0272]

[0273] 1 Sodium Laureth-1 Sulfate with 26% active ingredients, Supplier: P&G

[0274] 2 Oxymetholone, Supplier: Clariant

[0275] 3 Sodium chloride, Supplier: Morton

[0276] Discussion of the results of Examples 3-8

[0277] Neither the reduction in surfactant content in Examples 4 and 6 nor the reduction in product viscosity in Example 8 significantly affected deposition efficiency relative to their corresponding controls Examples 3, 5 and 7. In fact, Examples 4, 6 and 8 exhibited deposition efficiencies in the range of 0.9-1.2 times that of their corresponding controls.

[0278] Examples 9-13 below further illustrate embodiments of the present invention.

[0279]

[0280] 1 Sodium undecyl sulfate with 70% active substance, supplier: P&G

[0281] 2 Oxymetholone, Supplier: Clariant

[0282] 3 Limonene, Supplier: Kerry

[0283] 4 Linalyl isobutyrate, Supplier: Givaudan

[0284] 5 Sodium chloride, Supplier: Morton

[0285]

[0286] 1Sodium undecyl sulfate with 70% active substance, supplier: P&G

[0287] 2 Lauramidopropyl betaine with 35% active substance, supplier: Solvay

[0288] 3 Oxymetholone, Supplier: Clariant

[0289] 4 Limonene, Supplier: Kerry

[0290] 5 Mirapol 100 (40% active substance solution), supplier: Solvay Novecare

[0291] 6 Jaguar C-500, viscosity = 25-65 cps, nitrogen % = 1.15-1.45%, supplier: Solvay Novecare

[0292] 7 UCARE Polymer JP, 2% solution viscosity = 30000, nitrogen % = 0.8-1.1%, supplier: Dow Chemicals

[0293] 8 Sodium chloride, Supplier: Morton

[0294] Microscopy Sample Preparation Methods

[0295] 10:1 dilution sample preparation: Weigh 10.00 ± 0.05 g of tap water into a glass vial. Add 1.00 ± 0.02 g of shampoo to the tap water. Close the vial cap tightly and shake vigorously back and forth 20 times. Allow the sample to stand for 5-24 hours until the milky phase separates to the top.

[0296] 5:1 dilution sample preparation: Weigh 10.00 ± 0.05 g tap water into a glass vial. Add 2.00 ± 0.02 g shampoo to the tap water. Close the vial cap tightly and shake vigorously back and forth 20 times. Allow the sample to stand for 5-24 hours until the milky phase separates to the top.

[0297] Microscope Slide Preparation: Sample the top milky phase of the diluted sample using a 1 mL plastic bubble pipette and place a drop on a microscope slide, then place a glass microscope slide cover on top of the sample.

[0298] The diluted samples were evaluated using a differential interference contrast (DIC) microscope under a 40x objective. Images were captured with a camera using the imaging software AxioVs40 V 4.7.2.0 from CarlZeiss Imaging Solutions.

[0299] Discussion of the Results of Examples 11-13

[0300] Microscopy of the dilutions of Examples 11, 12 and 13 showed the presence of limonene oil droplets trapped in the aggregates. This demonstrates that upon dilution of the shampoo, the aggregates and limonene oil phase separated.

[0301]

[0302]

[0303] 1 Sodium Laureth-1 Sulfate with 26% active ingredients, Supplier: P&G

[0304] 2 Sodium undecyl sulfate with 70% active substance, supplier: P&G

[0305] 3 Oxymetholone, Supplier: Clariant

[0306] 4 Sodium chloride, Supplier: Morton

[0307] Discussion of the Results of Examples 14-15

[0308] For Example 14 (control), the ratio of the diffusion coefficients (D S / D A ) is close to 1.0, which indicates that octopirox olamine diffuses at the same rate as the SLE1S micelles, which allows the inference that octopirox olamine is inside the SLE1S micelles. However, in Example 15, in which SLE1S is replaced by sodium undecyl sulfate, the ratio (D S / D A ) is greater than 1.0. S / D A This change in indicates that octopirox olamine diffuses at a different rate from the sodium undecyl sulfate micelles, which allows the inference that octopirox olamine is not within those micelles. The significance of octopirox olamine not being within the surfactant micelles in Example 15 is reflected in the increased deposition efficiency of Example 15 relative to Example 14 (control).

[0309]

[0310]

[0311] 1 Sodium Laureth-1 Sulfate with 26% active ingredients, Supplier: P&G

[0312] 2 Sodium undecyl sulfate with 70% active substance, supplier: P&G

[0313] 3 Imidazolin, Supplier: Symrise

[0314] 4 Sodium chloride, Supplier: Morton

[0315] Discussion of the Results of Examples 16-18

[0316] For Example 16 (control), the ratio of the diffusion coefficients (D S / D A ) is close to 1.0, which indicates that imipenem diffuses at the same rate as the SLE1S micelles, which allows the inference that imipenem is inside the SLE1S micelles. However, in Examples 17-18, in which SLE1S is replaced by sodium undecyl sulfate, the ratio (D S / D A ) is significantly greater than 1.0. S / D A This change in the concentration of 1.5 wt% dapoxetine indicates that dapoxetine diffuses at a different rate from the sodium undecyl sulfate micelles, which allows the inference that dapoxetine is not within those micelles. Therefore, Examples 17-18 represent the present invention and show significantly higher deposition efficiencies, which are 1.9 to 2.5 times that of Example 16 (control). This indicates that the present invention can be widely applied to various soluble anti-dandruff agents.

[0317]

[0318]

[0319] 1 Sodium Laureth-1 Sulfate with 26% active ingredients, Supplier: P&G

[0320] 2 Sodium trideceth-2 sulfate with 65% active substance, Supplier: Tianjin TianzhiFine Chemical Co

[0321] 3 Sodium undecyl sulfate with 70% active substance, supplier P&G

[0322] 4Sodium decyl sulfate with 70% active substance, supplier: P&G

[0323] 5 Oxymetholone, Supplier: Clariant

[0324] 6 Sodium chloride, Supplier: Morton

[0325] Discussion of the Results of Examples 19-23

[0326] This group of examples demonstrates that a diffusion coefficient ratio (D) greater than 1.2 is achieved. S / D A ) is key to achieving the desired increase in deposition efficiency. Examples 20-22 are representative of the present invention and demonstrate that a diffusion coefficient ratio (D) greater than 1.2 is achieved with a variety of surfactants. S / D A ) is feasible. Thus, Examples 20-22 exhibit greater deposition efficiency (1.4-2.0 times) than Example 19 (control). Example 23 is a comparative example and shows that even when the formulation contains sodium undecyl sulfate, if D S / D A As it approaches 1.0, the deposition efficiency will be lower and similar to the control (Example 19).

[0327] In the examples, unless otherwise indicated, all concentrations are listed as weight percents, and trace materials, such as diluents, fillers, etc., may be excluded. Thus, the listed formulations include the listed components and any trace materials associated with such components. The selection of these trace components will vary depending on the physical and chemical properties of the specific ingredients selected to prepare the invention as described herein, as will be apparent to one of ordinary skill in the art.

[0328] The dimensions and values ​​disclosed herein should not be understood as being strictly limited to the exact values ​​cited. Instead, unless otherwise indicated, each such dimension is intended to represent the value and a functionally equivalent range around that value. For example, a dimension disclosed as "40 mm" is intended to mean "about 40 mm".

[0329] Unless expressly excluded or otherwise limited, each document cited herein, including any cross-referenced or related patent or patent application and any patent application or patent to which this application claims priority or the benefit of, is hereby incorporated by reference in its entirety. The citation of any document is not an admission that it is prior art with respect to any present invention disclosed or claimed herein, or that it alone or in combination with any other reference or references proposes, suggests or discloses any such invention. In addition, if any meaning or definition of a term in this document conflicts with any meaning or definition of the same term in a document incorporated by reference herein, the meaning or definition assigned to that term in this document shall prevail.

[0330] Although specific embodiments of the present invention have been illustrated and described, it will be apparent to those skilled in the art that various other changes and modifications may be made without departing from the spirit and scope of the present invention. Therefore, it is intended that all such changes and modifications within the scope of the present invention be encompassed in the appended claims.

Claims

1. A hair care composition comprising: a) 14% to 40% of one or more surfactants, said surfactant being an anionic surfactant or a combination of anionic surfactants; b) 0.1% to 10% of one or more surfactant-soluble anti-dandruff agents; Wherein when the hair care composition is diluted to a surfactant concentration of 1.3%, it has a ratio of the surfactant diffusion coefficient to the soluble anti-dandruff agent diffusion coefficient of 1.4-2.2, wherein at least one of the surfactants is a surfactant or a combination of multiple surfactants selected from the following group: decyl ammonium sulfate, sodium decyl sulfate, potassium decyl sulfate, undecyl ammonium sulfate, sodium undecyl sulfate, potassium undecyl sulfate, sodium trideceth-2 sulfate, sodium trideceth-3 sulfate, sodium tridecyl sulfate.

2. A hair care composition according to claim 1 further comprising from 0.25% to 15% of one or more amphoteric co-surfactants, nonionic co-surfactants or zwitterionic co-surfactants.

3. The hair care composition according to claim 2, wherein the auxiliary surfactant is selected from disodium capryloamphodiacetate, disodium capryloamphodipropionate, disodium capryloamphodiacetate, disodium capryloamphodipropionate, decyl polyglucoside, glyceryl monoesters of C12-22 branched fatty acids, polyglycerol esters of C12-22 branched fatty acids, sorbitan esters of C12-22 branched fatty acids, and triglycerol diisostearate.

4. The hair care composition according to claim 3, wherein the co-surfactant is selected from polyglyceryl-4 isostearate and sorbitan isostearate.

5. A hair care composition according to any one of the preceding claims 1-2, wherein the surfactant-soluble anti-dandruff agent is a hydroxypyridone.

6. The hair care composition according to claim 5, wherein the hydroxypyridone is octopirox olamine.

7. A hair care composition according to any one of the preceding claims 1-2, wherein the surfactant-soluble anti-dandruff agent is an azole.

8. The hair care composition according to claim 7, wherein the azole is imidaclopridone.

9. A hair care composition according to any one of the preceding claims 1-2, wherein the composition further comprises a cationic polymer.

10. A hair care composition according to any preceding claim 1-2, wherein the composition further comprises a conditioning agent.

11. The hair care composition of claim 10, wherein the conditioning agent is silicone.

12. A hair care composition according to any one of the preceding claims 1-2, further comprising one or more scalp health agents.

13. The hair care composition of claim 12, wherein the scalp health agent is zinc pyrithione.

14. The hair care composition of claim 12, wherein the scalp health agent is salicylic acid.

15. The hair care composition of claim 12, wherein the scalp health agent is menthol and / or menthyl lactate.

16. A hair care composition according to any preceding claim 1-2, further comprising from 1% to 7% of perfume.

17. The hair care composition according to any one of the preceding claims 1-2, wherein the hair care composition is dispensed as a foam.

18. The hair care composition according to any one of the preceding claims 1-2, wherein the hair care composition is dispensed as an aerosol foam.

19. The hair care composition of claim 18, wherein the propellant or blowing agent for dispensing the composition as an aerosol foam is a chemically inert hydrocarbon, halogenated hydrocarbon, and mixtures thereof.

20. The hair care composition according to any one of the preceding claims 1-2, wherein the hair care composition is dispensed as a pump foam.

21. The hair care composition according to any one of the preceding claims 1-2, wherein the hair care composition is applied using an applicator.

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