A detection device

Abstract

The present invention provides a detection device, including a storage cavity, an additive in the storage cavity, a sharp portion in the detection device, the storage cavity can move relative to the sharp portion, during the movement of the storage cavity, the storage cavity will be punctured by the sharp portion, so that the additive in the storage cavity is released, and also includes a collection cavity, the released additive can enter the collection cavity, the collection cavity is used to accommodate samples, the collection cavity is arranged in a first shell, an opening is arranged at the upper side of the first shell, a test element for detecting the analyzed substance is arranged in the collection cavity, the test element is arranged on a carrier, and the carrier and the collection cavity have a specific matching form. The buffer solution is arranged in an independent cavity in the detection device, and the buffer solution can be obtained at any time when the detection is required, which is very convenient to use; the carrier and the collection cavity in the first shell have a specific matching form, so that the carrier has a definite and unique direction position after being inserted into the collection cavity.

Description

Technical Field

[0001] The present invention relates to the technical field of in vitro rapid detection, in particular to a device for collecting and detecting substances to be analyzed in a liquid sample in the field of rapid diagnosis, such as a urine or saliva collection and detection device. Background Art

[0002] The following background technology introduction is merely an introduction to some background common sense and does not constitute any limitation to the present invention.

[0003] At present, detection devices for detecting whether a sample contains an analyte are widely used in hospitals or homes. These detection devices for rapid diagnosis include one or more test strips, such as early pregnancy tests, drug abuse tests, etc. This rapid diagnosis detection device is very convenient and can obtain test results on the test strip in one minute, or at most ten minutes.

[0004] Drug testing is widely used and samples can be urine, sweat, hair and saliva samples.

[0005] In some tests, in order to obtain more accurate test results, testers will add buffer to the sample during the test process, so as to keep the pH value of the solution relatively stable to a certain extent. However, since the buffer will breed bacteria if it is exposed to air at room temperature for a long time, and the bacterial metabolites will change the pH value of the buffer, in order to avoid contact with air, the buffer is generally not directly placed in the test device. In most cases, the buffer is stored separately from the test device and added during the test. This method is very cumbersome to operate.

[0006] This requires improvements to existing traditional detection devices, providing a simpler way to collect samples and perform detection. Summary of the invention

[0007] The object of the present invention is to provide a detection device to solve the problems raised in the above background technology.

[0008] To achieve the above-mentioned purpose, the technical solution adopted by the present invention is a detection device, including a storage cavity with additives in it, a sharp portion in the detection device, and the storage cavity can move relative to the sharp portion. During the movement of the storage cavity, the storage cavity will be punctured by the sharp portion, thereby releasing the additives in the storage cavity.

[0009] Furthermore, it also includes a collecting chamber, and the released additives can enter the collecting chamber.

[0010] Furthermore, the collecting chamber is used to contain the sample, the collecting chamber is arranged in the first shell, and an opening is arranged at the upper side of the first shell. Furthermore, a test element for detecting the substance to be analyzed is arranged in the collecting chamber.

[0011] Furthermore, the test element is arranged on the carrier, and the carrier and the collecting cavity have a specific matching form. The carrier can be inserted into the collecting cavity from the opening at the upper side of the first shell, and has a definite and unique directional position when the carrier is inserted into the collecting cavity.

[0012] Furthermore, a clamping strip is provided in the collecting chamber, and a carrier is fixed by two clamping strips, and one side of the carrier on which the test element is mounted is in contact with an inner wall of one side of the collecting chamber.

[0013] Furthermore, the thickness of the upper end of the card strip is smaller, and the thickness of the lower end is larger; correspondingly, the thickness of the bottom position of the carrier is smaller, and the thickness of the top position of the carrier is larger.

[0014] Furthermore, the corners of the collecting chamber are provided with rounded corners; correspondingly, both sides of the side of the carrier on which the test element is mounted are also provided with rounded corners.

[0015] Furthermore, it also includes a sample collector for collecting samples, the sample collector includes a covering end, and the covering end can be used to cover the opening of the collection cavity.

[0016] Furthermore, the sample collector also includes a sampling end and a rod body, the sampling end is connected to the absorption element, the rod body is used to connect the covering end and the sampling end, and the rod body is detachably connected to the covering end.

[0017] Furthermore, a hole is provided on the sample collector and / or the collecting chamber, and the hole enables gas communication between the collecting chamber and the outside.

[0018] Furthermore, a hollow tube extending toward the collecting chamber is provided on the cover end at the hole position.

[0019] Further, the diameter of the hole is less than 1 mm.

[0020] Furthermore, the liquid in the storage chamber is a buffer solution.

[0021] Furthermore, a connector is provided on the side of the cover end of the sample collector facing away from the rod body, the interior of the connector is hollow, and the storage cavity can enter into the hollow position thereof.

[0022] Furthermore, the sharp portion is in a protruding shape and is arranged at a hollow position of the connector.

[0023] Furthermore, the storage cavity is arranged in the second shell, and a sealing film is provided on the second shell for sealing the liquid in the storage cavity. The storage cavity enters into the hollow position of the connector, and the sharp portion can pierce the sealing film on the second shell, thereby releasing the liquid in the storage cavity.

[0024] Furthermore, a through hole penetrating from top to bottom is provided on the sharp portion.

[0025] Furthermore, a second sealing ring is provided on the second shell, and the second sealing ring can fill the gap between the second shell and the connecting head.

[0026] Furthermore, the detection device also includes a cover body, which is connected to the second shell body, and this connection relationship is detachable or non-detachable.

[0027] Furthermore, the cover body and the connector can cover each other.

[0028] Furthermore, the cover body and the connecting head are provided with matching threads.

[0029] Furthermore, the cover body and the second shell have a rotating part at the upper end of the second shell, the rotating part has a first protrusion, and the cover body has a connecting hole. The rotating part can be inserted into the connecting hole and buckled on the connecting hole through the first protrusion, so that the second shell can rotate on the connecting hole.

[0030] Furthermore, the detection device also includes a protection element for limiting excessive closing of the cover body.

[0031] Furthermore, the detection device also includes a protective element for limiting excessive closing of the cover body, the protective element includes a supporting section, the supporting section is sleeved on the connecting head, the lower end of the supporting section can abut against the upper surface of the closing end, and the upper end of the supporting section can abut against the cover body.

[0032] Furthermore, the supporting section is in the shape of a hollow cylinder and is sleeved on the connecting head.

[0033] Furthermore, a first notch is provided on the supporting section of the protection element.

[0034] Furthermore, the protection element has elasticity.

[0035] Furthermore, the protection element also includes a gripping portion, on which stripes are provided, the gripping portion is connected to the supporting section, and the connection position between the gripping portion and the supporting section is just opposite to the first notch.

[0036] Furthermore, the protective element is provided with a second protrusion protruding inward at the bottom position of the support section, and the second protrusion is annular. Correspondingly, the connecting head is also provided with an annular structure near the bottom position, and the second protrusion can be inserted into the gap between the annular structure and the upper surface of the covering end.

[0037] Furthermore, a second notch is provided on the annular structure, and correspondingly, a third protrusion is provided on the inner side of the supporting section of the protection element facing the first notch, and the third protrusion can be embedded in the second notch.

[0038] Furthermore, the covering end is rectangular, and the second notch is located on a side close to the long side of the covering end.

[0039] Furthermore, a retaining wall is provided on the supporting section of the protection element, and the retaining wall is arc-shaped.

[0040] Furthermore, the inner diameter of the protection element at the retaining wall position is greater than the inner diameter of the protection element at the supporting section position.

[0041] Furthermore, a buckle is provided on the inner side of the retaining wall, and a circle of flange is provided at the bottom position of the cover body, and the flange of the cover body can enter into the retaining wall and be buckled under the buckle.

[0042] Furthermore, the upper end of the flange is horizontal, and the lower end surface of the buckle is also horizontal; the upper end of the buckle is inclined, and a chamfer is provided at the lower side of the flange of the cover body.

[0043] In summary, the beneficial effects of the present invention are as follows: the buffer solution is arranged in an independent cavity in the detection device, and the buffer solution can be obtained at any time when detection is required, which is very convenient to use; the carrier and the collection cavity in the first shell have a specific matching form, so that the carrier has a definite and unique direction position after being inserted into the collection cavity; a hole is provided on the sample collector to connect the collection cavity with the external gas, which can eliminate the covering problem caused by the air pressure during the use of the detection device, and at the same time, a hollow tube extending in the direction of the collection cavity is provided at the hole position on the covering end, which can avoid leakage of the sample; an upwardly open truncated cone-shaped extrusion portion is provided at the bottom of the collection cavity, and when the absorption element on the sampling end contacts the extrusion portion to squeeze the sample, in addition to the absorption element and the bottom of the extrusion portion being squeezed, the truncated cone-shaped opening can also squeeze the side of the absorption element, which improves the squeezing efficiency, and can also release more liquid samples, and can also play a certain collection role on the sample; the detection device also includes a protective element for limiting excessive covering of the cover body, which can prevent the storage cavity from being punctured by a sharp portion before detection; a plurality of grooves are provided on the outer surface of the carrier, which can be used to install different test elements to achieve the function of single multiple detection. BRIEF DESCRIPTION OF THE DRAWINGS

[0044] Figure 1 It is a schematic diagram of the overall structure of the detection device;

[0045] Figure 2 It is a completely exploded view of the detection device;

[0046] Figure 3 is a schematic diagram of a carrier installed in a first housing;

[0047] Figure 4 is a front cross-sectional view of the first shell;

[0048] Figure 5 is a side sectional view of the first housing;

[0049] Figure 6 It is an exploded view of the detection device when in use;

[0050] Figure 7 yes Figure 6 A partial enlarged schematic diagram of the "A" area in the middle;

[0051] Figure 8 is a top view of the first shell;

[0052] Fig. 9 It is a schematic diagram of the structure of the cover end;

[0053] Fig.10 is a schematic diagram of the structure in which the second shell is installed in the cover body;

[0054] Fig.11 It is a structural diagram of the protection element. DETAILED DESCRIPTION

[0055] The structures involved in the present invention or the technical terms used are further explained below. If not specifically specified, they are understood and interpreted according to the general terms commonly used in the art.

[0056] Detection

[0057] Detection means to test or examine a substance or material for the presence or absence of a substance or material, such as, but not limited to, a chemical substance, an organic compound, an inorganic compound, a metabolite, a drug or a drug metabolite, an organic tissue or a metabolite of an organic tissue, a nucleic acid, a protein, or a polymer. In addition, detection means to test the amount of a substance or material. Furthermore, assay also means immunoassay, chemical assay, enzyme assay, etc.

[0058] sample

[0059] The detection device of the present invention or the sample collected includes biological fluid (such as case fluid or clinical sample). Liquid sample or liquid sample, or fluid sample or fluid sample, can be derived from solid or semi-solid sample, including excrement, biological tissue and food sample. Solid or semi-solid sample can be converted into liquid sample by any appropriate method, such as mixing, crushing, maceration, incubation, dissolution or utilizing enzymolysis to digest solid sample in suitable solution (such as water, phosphate solution or other buffer solution). "Biological sample" includes deriving from animal, plant and food sample, such as urine, saliva, blood and its components, cerebrospinal fluid, vaginal secretion, sperm, feces, sweat, secretion, tissue, organ, tumor, culture of tissue and organ, cell culture and medium derived from human or animal. Preferably, biological sample is urine, preferably, biological sample is saliva. Food sample includes food processed material, final product, meat, cheese, wine, milk and drinking water. Plant sample includes any plant, plant tissue, plant cell culture and medium derived from. An "environmental sample" is derived from the environment (e.g., liquid samples from lakes or other bodies of water, sewage samples, soil samples, groundwater, seawater, and wastewater samples). Environmental samples may also include sewage or other wastewater.

[0060] By using the suitable detection element or test element of the present invention, any analyte can be detected. The present invention is preferably used to detect drug molecules in saliva and urine. Of course, the collection device of the present invention can collect any form of samples above, whether solid or liquid at the beginning, as long as these liquids or liquid samples can be absorbed by the absorption element. The absorption element here is generally prepared by water-absorbing materials, which are dry at the beginning, and can absorb liquid samples or fluid samples through the capillary or other characteristics of the absorption element material. The absorption material can be any material that can absorb liquid, such as sponge, filter paper, polyester fiber, gel, non-woven fabric, cotton, polyester film, yarn, etc. Of course, the absorption element is not necessarily prepared by absorption material, but can be prepared by non-absorbent material, but there are holes, threads, and caves on the absorption element, and samples can be collected on these structures. These samples are generally solid or semi-solid samples, and these samples are filled between the threads, holes, or holes.

[0061] Downstream and Upstream

[0062] Downstream or upstream is divided according to the direction of liquid flow. Generally, liquid flows from upstream to downstream area. The downstream area receives liquid from the upstream area, and liquid can also flow from the upstream area to the downstream area. Here, it is generally divided according to the direction of liquid flow. For example, on some materials that use capillary force to promote liquid flow, liquid can flow in the opposite direction of gravity due to gravity. At this time, upstream and downstream are still divided according to the flow direction of the liquid.

[0063] Gas connection or liquid connection

[0064] Gas connectivity or liquid connectivity means that liquid or gas can flow from one place to another, and some physical structures may be used to guide the flow. The so-called passing through physical structures generally refers to the liquid passing through the surface of these physical structures, or the internal space of these structures and passively or actively flowing to another place. Passive flow is generally caused by external force, such as flow under capillary action. The flow here can also be the liquid or gas due to its own action (gravity or pressure), or it can be passive flow. The connectivity here does not necessarily mean that liquid or gas must exist. It only indicates the connection relationship or state between two objects in some cases. If there is liquid, it can flow from one object to another. This refers to the state of connection between two objects. On the contrary, if there is no liquid connectivity or gas connectivity between the two objects, if there is liquid in or on one object, the liquid cannot flow into or on another object. This state is non-connected, non-liquid or gas connected.

[0065] Test components

[0066] Here, the so-called "test element" refers to an element that can detect whether a sample or a specimen contains an analyte of interest. This detection can be based on any technical principle, such as immunology, chemistry, electricity, optics, molecular science, nucleic acid, physics, etc. The test element can be a lateral flow test strip, which can detect a variety of analytes. Of course, other suitable test elements can also be used in the present invention.

[0067] Various test elements can be combined and applied to the present invention. One form is a test strip. The test strip used to analyze the analyte in the sample (such as drugs or metabolites indicating physical conditions) can be in various forms, such as immunoassays or chemical analysis. The test strip can adopt a non-competitive or competitive analysis mode. The test strip generally comprises a water-absorbing material with a sample application area, a reagent area and a test area. The sample is added to the sample application area and flows to the reagent area through capillary action. In the reagent area, if the analyte is present, the sample binds to the reagent. Then the sample continues to flow to the detection area. Other reagents, such as molecules that specifically bind to the analyte, are fixed in the detection area. These reagents react with the analyte in the sample (if present) and bind the analyte to the area, or bind to a reagent in the reagent area. The marker used to display the detection signal is present in the reagent area or a separate labeling area.

[0068] The typical non-competitive assay format is that if the sample contains the analyte, a signal is generated, and if it does not contain the analyte, no signal is generated. In a competitive assay, if the analyte is not present in the sample, a signal is generated, and if the analyte is present, no signal is generated.

[0069] The test element can be a test paper, which can be made of absorbent or non-absorbent materials. The test paper can include multiple materials for liquid sample delivery. One material of the test paper can be covered on another material, such as filter paper covered on a nitrocellulose membrane. One area of ​​the test paper can be made of one or more materials, while another area can be made of one or more different materials. The test paper can be adhered to a certain support or hard surface to increase the strength of holding the test paper.

[0070] The analyte is detected through a signal generating system, such as by using one or more enzymes that react specifically with the analyte, and by using the method of fixing the specific binding substance on the test paper as described above, to fix the composition of one or more signal generating systems on the analyte detection area of ​​the test paper. The substance that generates the signal can be in the sample addition area, the reagent area, or the detection area, or on the entire test paper, and the substance can be filled with one or more materials of the test paper. A solution containing the signal substance is added to the surface of the test paper or one or more materials of the test paper are immersed in a solution containing the signal substance. The test paper to which the solution containing the signal substance is added is dried.

[0071] The various zones of the test strip can be arranged in the following manner: sample addition zone, reagent zone, test zone, control zone, zone for determining whether the sample is adulterated, and liquid sample absorption zone. The control zone is located after the test zone. All zones can be arranged on a test strip using only one material. Different materials can also be used in different zones. Each zone can be directly in contact with the liquid sample, or different zones can be arranged according to the direction of liquid sample flow, with the end of each zone connected to the front end of another zone and overlapping. The material used can be a material with good water absorption such as filter paper, glass fiber or nitrocellulose membrane. The test strip can also be in other forms.

[0072] The commonly used reagent strip is a nitrocellulose membrane reagent strip, that is, the detection area includes a nitrocellulose membrane, and specific binding molecules are fixed on the nitrocellulose membrane to display the detection results; it can also be a cellulose acetate membrane or a nylon membrane, etc. For example, the following patents describe reagent strips or devices containing reagent strips: US 4857453; US 5073484; US 5119831; US ​​5185127; US 5275785; US 5416000; US 5504013; US 5602040; US 5622871; US5654162; US 5656503; US 5686315; US 5766961; US ​​5770460; US 5916815; US 5976895; US6248598; US 6140136; US 6187269; US 6187598; US 6228660; US 6235241; US The test strips and similar devices with test strips disclosed in the above patent documents can be applied to the test element or detection device of the present invention to detect the analyte, such as the analyte in the sample.

[0073] The test strip used in the present invention can be a so-called lateral flow test strip. The specific structure and detection principle of these test strips are well known to those skilled in the art in the prior art. Common test strips include a sample collection area or a sample application area, a labeling area, a detection area and a water absorption area. The sample collection area includes a sample receiving pad, the labeling area includes a labeling pad, and the water absorption area may include a water absorption pad. The detection area includes necessary chemical substances that can detect whether the analyzed substance is contained, such as an immunoreagent or an enzyme chemical reagent. The commonly used test strips are nitrocellulose membrane test strips, that is, the detection area includes a nitrocellulose membrane, and specific binding molecules are fixed on the nitrocellulose membrane to display the test results; it can also be a cellulose acetate membrane or a nylon membrane, etc. Of course, the downstream of the detection area can also include a test result control area. Usually, the control area and the detection area appear in the form of horizontal lines, which are detection lines or control lines. Such a test strip is a traditional test strip. Of course, it can also be other types of test strips that use capillary action for detection. In addition, generally, the test strips carry dry chemical reagent components, such as fixed antibodies or other reagents. When the liquid encounters the liquid, the liquid flows along the test strip by capillary action. As the liquid flows, the dry reagent components are dissolved in the liquid, and then the liquid is processed in the next area to react with the dry reagent in the area, so as to perform the necessary test. The liquid flows mainly by capillary action. Here, they can all be applied to the detection device of the present invention, or be set in the detection chamber to contact the liquid sample, or be used to detect the presence or amount of the analyzed substance in the liquid sample entering the detection chamber.

[0074] In addition to the above test strips or lateral flow test strips being used to contact the liquid sample to test whether the liquid sample contains the substance to be analyzed. In some preferred embodiments, the test element can also be arranged on some carriers, such as Figure 3As shown, for example, on some carriers 40, there are many grooves 43 on the carrier, and the test element is located in the groove 43. In some ways, the carrier 40 includes a groove area for setting the test element, and multiple grooves are set in the area. Each groove can be set with a test strip, and each test strip can detect an analyte. The carrier 40 is in a form that matches the collection chamber 22. For example, the collection chamber 22 is a square cavity here. Correspondingly, a plate-shaped carrier 40 can be placed in the collection chamber 22. Multiple grooves 43 are set on the outer surface of the carrier 40. These grooves 43 are also evenly arranged in an array. The test element is placed in the groove 43. The test element can be a test strip. Sharp corners 41 are set on both sides of the groove 43. The sharp corners 41 can clamp the test strip in the groove 43, mainly playing a role in fixing the test strip. In some ways, after the test element is set in the groove 43 of the carrier 40, a layer of transparent film is covered on the carrier 40. One is to seal the groove area of ​​the carrier 40, and the other is that the transparent film makes it easy to observe the test results on the final detection area. The transparent film may also be a transparent plastic sheet, which only needs to be transparent in the test area.

[0075] Generally, the test strip includes a sample application area, a label area and a detection area. When the test strip is placed, the sample application area is placed near the bottom of the carrier, and then slightly exposed from the groove, such as 2-3 mm. The reserved part of the sample application area is used to absorb the fluid sample flowing into the bottom of the collection chamber 22. Generally, the sample application area is located upstream of the label area, and the label area is located upstream of the detection area.

[0076] Carrier and collection chamber

[0077] The collection chamber is a place for accommodating samples. The first shell 20 is provided with a collection chamber 22. The collection chamber 22 includes an opening at the upper side of the first shell 20. The carrier 40 is inserted into the collection chamber 22 from the opening at the upper side of the first shell 20. In some embodiments, the carrier 40 is in a form that has a specific match with the collection chamber 22. With such a matching form, the carrier has a definite and unique direction position after being inserted into the collection chamber. For details, refer to the attached Figure 5 A card strip 21 is provided in the collection chamber 22. A carrier 40 is preferably fixed by two card strips 21. The two card strips 21 can restrict the carrier 40 in the collection chamber 22 by restricting the two sides of the carrier 40 and make the side of the carrier 40 with the test strip fit with the inner wall of one side of the collection chamber 22. The first shell 20 is preferably made of a transparent material, so that the tester can directly read the test result from the carrier 40. Further, referring to the attached Figure 5, the thickness of the upper end of the card strip 21 is smaller, and the thickness of the lower end is larger. Correspondingly, the thickness of the bottom position of the carrier 40 is smaller, and the thickness of the top position of the carrier 40 is larger. Such a design prevents the carrier 40 from being inserted into the collection chamber 22 upside down. In addition, the corners of the collection chamber 22 are provided with rounded corners, and correspondingly, the two sides of the side of the carrier 40 equipped with the test strip are also provided with rounded corners, so that the carrier 40 can only slide down when the side equipped with the test strip fits with the inner wall of the collection chamber 22. When the side of the carrier 40 facing away from the test strip fits with the inner wall of the collection chamber 22 and slides down, since the two sides of the side of the carrier 40 facing away from the test strip are non-rounded corners (both sides are sharp corners), during the sliding process, the non-rounded corners will be stuck with the rounded corners of the corners of the collection chamber 22, resulting in the inability of the carrier 40 to be loaded into the collection chamber 22, thus realizing a specific matching form between the carrier 40 and the collection chamber 22.

[0078] Analyte

[0079] Examples of analytes that can be used in the present invention include small molecules, including drugs (such as drugs of abuse). "Drugs of abuse" (DOA) refer to the use of drugs for non-medical purposes (usually to paralyze nerves). Abuse of these drugs can lead to physical and mental damage, dependence, addiction and / or death. Examples of drugs of abuse include cocaine; amphetamines AMP (e.g., Black Beauty, White Amphetamine Pills, Dextroamphetamine, Dextroamphetamine Pills, Beans); methamphetamines MET (crank, methamphetamine, crystal, speed); barbiturates BAR (e.g., Valium, Roche Pharmaceuticals, Nutley, New Jersey); sedatives (i.e., sleep aids); lysergic acid diethylamide (LSD); depressants (downers, goofballs, barbs, blue devils, yellowjackets, methaqualone); tricyclic antidepressants (TCAs, i.e., imipramine, amitriptyline, and doxepin); dimethyldioxymethamphetamine MDMA; phencyclidine (PCP); tetrahydrocannabinol (THC , pot, dope, hash, weed, etc. ); opiates (i.e. morphine MOP or opium, cocaine COC, heroin, hydroxydihydrocodone); antianxiety drugs and sedatives and hypnotic drugs. Antianxiety drugs are a class of drugs mainly used to relieve anxiety, tension, fear, stabilize emotions, and have hypnotic and sedative effects, including benzodiazepines BZO (benzodiazepines), atypical BZs, fused diazepam NB23Cs, benzodiazepines, BZ receptor ligands, open-ring BZs, diphenylmethane derivatives, piperazine carboxylates, piperidine carboxylates, quinazolinones, thiazine and thiazole derivatives, other heterocyclics, imidazole sedatives / analgesics (such as hydroxydihydrocodone OXY, methadone MTD), propylene glycol derivatives-carbamates, aliphatic compounds, anthracene derivatives, etc. The detection device of the present invention can also be used to detect drugs that are for medical purposes but are prone to overdose, such as tricyclic antidepressants (imipramine or analogs) and acetaminophen. These drugs are metabolized into small molecules after being absorbed by the human body. These small molecules exist in body fluids such as blood, urine, saliva, sweat, etc., or in some body fluids.

[0080] For example, the analytes detected by the present invention include, but are not limited to, creatinine, bilirubin, nitrite, protein (non-specific), hormones (e.g., human chorionic stimulating hormone, progesterone hormone, follicle stimulating hormone, etc.), blood, white blood cells, sugars, heavy metals or toxins, bacterial substances (such as protein or sugar substances for specific bacteria, such as Escherichia coli 0157: H7, Staphylococcus, Salmonella, Clostridium, Campylobacter, L.monocytogenes, Vibrio, or Bacillus cereus) and substances related to physiological characteristics in urine samples, such as pH and specific gravity. Any other clinical urine chemical analysis can be detected using the lateral flow detection format in conjunction with the device of the present invention.

[0081] Liquid Flow

[0082] The flow of liquid usually refers to the flow from one place to another. Generally speaking, the flow of liquid in nature mostly relies on the action of gravity to flow from high to low. The flow here also relies on external force, that is, the flow under external gravity, which can be called the flow of natural gravity. In addition to gravity, the flow of liquid can also overcome gravity and flow from low to high. For example, the extraction of liquid, or the compression of liquid, or the liquid receives pressure and flows from the bottom to high, or the flow caused by the gravity of the liquid itself due to the concern of pressure. For example, in the present embodiment, if there is a liquid sample in the collection chamber 22, the liquid sample will be gathered to the bottom of the collection chamber 22 under the action of gravity. When the liquid sample at the bottom of the collection chamber 22 contacts the lower end of the test paper on the carrier 40, the liquid sample begins to flow from bottom to top by capillary force for detection.

[0083] Sample collector and collection chamber

[0084] The sample collector is used to collect samples, such as Figure 6 As shown, the sample collector 30 includes a covering end 31, a rod body 32, and a sampling end 33. The covering end 31 can be used to cover the opening of the collecting chamber 22 to prevent the sample in the collecting chamber 22 from leaking out. The sampling end 33 is used to connect the absorption element. The absorption element can be a non-toxic sponge with strong water absorption. The absorption element and the sampling end 33 can be bonded by special glue. When the sample collector 30 is inserted into the collecting chamber 22 along the opening of the collecting chamber 22, the absorption element (not shown) on the sampling end 33 is squeezed with the bottom of the collecting chamber 22, and the sample is squeezed out of the absorption element. As the sample collector 30 continues to move downward, the liquid sample in the absorption element is continuously squeezed out until the covering end 31 completely covers the opening of the collecting chamber 22. At this time, the sample collector 30 cannot continue to move downward, and the absorption element is also in a squeezed state.

[0085] Preferably, the upper end of the rod body 32 is detachably connected to the covering end 31, for example, by threaded connection, which is convenient for production.

[0086] During the process of the closing end 31 closing the collection chamber 22, due to the airtightness of the collection chamber 22, as the closing end 31 closes, the air pressure inside the collection chamber 22 will become larger and larger, which may cause the closing end 31 to be unable to close completely (the closing is not secure), or the closing end 31 is easy to pop out after closing. Preferably, in order to eliminate the influence of air pressure, a hole that allows the collection chamber 22 to communicate with the outside air should be set on the sample collector 30 and / or the collection chamber 22. For example, the attached Figure 7 In the embodiment, a hole 35 is provided on the cover end 31, and the diameter of the hole 35 is less than 1 mm. The cover end 31 provided with the hole 35 can well cover the collection chamber 22. Although the setting of the hole 35 can solve the air pressure problem, the setting of the hole 35 also makes it possible for the cover end 31 to leak the liquid sample. In order to avoid the leakage of the liquid sample as much as possible, a hollow tube 36 extending toward the collection chamber 22 is provided at the position of the hole 35 on the cover end 31. The hollow tube 36 can still keep the inside of the collection chamber 22 connected with the outside. At the same time, when the detection device is inverted, the liquid sample is collected at the cover end 31 under the action of gravity, and the hollow tube 36 raises the height of the hole at the connection position, so that the hole cannot contact the liquid sample, that is, the liquid sample cannot leak from the hole 35. At the same time, the diameter of the hole 35 is also very small. Due to the existence of water tension, the possibility of liquid sample leakage is further reduced.

[0087] Preferably, in order to allow the absorption element on the sampling end 33 to squeeze out as much liquid sample as possible when it is squeezed against the bottom of the collecting chamber 22, an extrusion portion 23 is provided at the bottom of the collecting chamber 22, and the extrusion portion 23 is provided with an opening 24 that opens upward, and the opening 24 is larger at the top and smaller at the bottom, and is in the shape of a truncated cone. When the absorption element on the sampling end 33 contacts the extrusion portion 23 to squeeze the sample, in addition to the absorption element being squeezed against the bottom of the extrusion portion 23, the truncated cone-shaped opening 24 can also squeeze the side of the absorption element, which improves the squeezing efficiency and can also release more liquid samples. In addition, it can also play a certain collecting role for the samples.

[0088] Here, the absorption element is used to absorb liquid samples, such as saliva, urine, sweat or other samples. The material of the absorption element can be any water-absorbent material, such as sponge and the like.

[0089] Preferably, the collecting chamber 22 is provided with sample slots 25 located on both sides of the squeezing portion 23, and the sample slots 25 are located directly below the carrier 40. A connecting slot 26 connecting the two sample slots 25 is provided at the center of the squeezing portion 23. The connecting slot 26 allows the liquid heights in the two sample slots 25 to remain consistent when the detection device is placed flat. Since the carrier 40 is located directly above the connecting slot 26, when the samples in the sample slots 25 are collected, the samples in the two sample slots 25 will simultaneously contact the lower ends of the detection papers on the two carriers 40 for detection, thereby avoiding the situation where one carrier 40 has started detection while the other carrier 40 has not started detection. Furthermore, the height of the connecting slot 26 is lower than the height of the squeezing portion 23, so that the samples released by the squeezing of the absorption element can flow into the sample slot 25 as much as possible.

[0090] Preferably, two drainage ports 27 are provided in the collecting chamber 22 at both sides of the sample slot 25 , and the drainage ports 27 can guide the spilled samples that do not fall on the squeezing portion 23 into the sample slot 25 .

[0091] Preferably, in order to enable the closing end 31 to better close the opening of the collection chamber 22, a first sealing ring 34 is provided on the closing end 31. The first sealing ring 34 is elastic and can well seal the closing end 31 with the opening of the collection chamber 22 to prevent the liquid sample from flowing out. At the same time, the first sealing ring 34 increases the friction force so that the closing end 31 is not easily separated from the opening of the collection chamber 22. When the closing end 31 closes the opening of the collection chamber 22, the absorption element is always in a compressed state, and the liquid sample can be continuously released into the collection chamber 22.

[0092] Collection chamber and storage chamber

[0093] The storage chamber is used to store additives, which can be solid, liquid, or gaseous. Common additives are liquid, such as buffer solutions. The buffer solution is sealed separately in the storage chamber 90. After the sample collector has collected the sample, it is necessary to open the storage chamber 90 and add the buffer solution therein to the collection chamber 22 to mix with the sample. The resulting mixed liquid is contacted with the test paper on the carrier 40 for detection. The amount of sample sampling of the absorption element is controlled by designing the size of the absorption element, or the amount of sample required when the sample contacts the test paper is controlled by designing the size of the sample slot 25, so that the liquid sample that can be absorbed by the absorption element on the sample collector is completely released, and the sample located in the sample slot 25 cannot contact the test paper. Only after the buffer solution in the storage chamber 90 is added to the collection chamber 22 can the resulting mixed liquid contact the test paper. Such a design can make the detection of the detection device more accurate.

[0094] Preferably, in the present invention, the storage chamber 90 is a separate chamber, which can be separated from the collection chamber 22. The storage chamber 90 is arranged in the second shell 91. The second shell 91 is provided with a sealing film 92. The sealing film 92 can be made of aluminum foil to seal the buffer solution in the storage chamber 90.

[0095] Preferably, in order to improve the integrity of the detection device and make it more convenient for detection personnel to use, a connecting head 37 is provided on the side of the covering end 31 of the sample collector 30 facing away from the rod body 32. The inside of the connecting head 37 is hollow, and the second shell 91 can enter its hollow position. The hollow position of the connecting head 37 is also provided with an upwardly protruding sharp portion 38, and the sharp portion 38 is provided with a through hole 39 running through from top to bottom. When one side of the sealing film 92 on the second shell 91 is squeezed by the sharp portion 38, the sealing film 92 is punctured, and the liquid in the storage chamber 90 leaks out and enters the collection chamber 22 through the through hole 39 to mix with the sample. Furthermore, since the second shell 91 can enter the hollow position of the connector 37, there is a gap between the second shell 91 and the connector 37. When the sealing membrane 92 is punctured, the buffer solution in the storage chamber 90 may leak out from the gap position, causing leakage of the buffer solution. In order to solve this problem, a second sealing ring 93 is installed on the second shell 91. The second sealing ring 93 is preferably elastic. When the second shell 91 enters the connector 37, the second sealing ring 93 fills the gap between the second shell 91 and the connector 37, thereby solving the problem of buffer solution leakage.

[0096] After the second sealing ring 93 is introduced, as the storage chamber 90 moves toward the hollow position of the connector 37, the air pressure in the storage chamber 90 may increase, thereby hindering the movement of the storage chamber 90. The hole 35 provided on the covering end 31 can effectively eliminate the influence of the air pressure in the storage chamber 90, thereby solving the potential technical problem here.

[0097] Cover

[0098] Since the second shell 91 can be taken out of or loaded into the connector 37, they are two parts. When the two parts are in use, the inspector, who is not familiar with the use of the device, may easily mistake a part for being useless, resulting in the loss of the part. In order to solve this problem, it is necessary to enhance the integrity of the detection device so that the inspector can know how to use the device when he sees it and know that the two parts are used together. Preferably, the detection device also includes a cover body 80, which is connected to the second shell 91. This connection relationship can be detachable or non-detachable. The cover body 80 and the connector 37 can cover each other. For example, the common cover body 80 and the connector 37 are provided with matching threads, so that the cover body 80 can be screwed onto the connector 37. During the tightening of the cover body 80, the cover body 80 drives the second shell 91 to move toward the sharp portion 38 until the sharp portion 38 pierces the sealing membrane 92.

[0099] After the detection device includes the cover body 80, the second sealing ring 93 may not be provided, because the cover body 80 can also play a certain role in preventing leakage. As a preferred technical solution, the detection device still retains the second sealing ring 93, because when the sharp portion 38 punctures the sealing film 92, the cover body 80 is not completely closed. Although the cover body 80 can play a certain role in preventing leakage, it cannot completely avoid that when the second sealing ring 93 is provided on the second shell 91, since the second sealing ring 93 seals the gap between the second shell 91 and the connector 37, if the cover body 80 and the second shell 91 are connected in a non-detachable manner, that is, a common fixed connection, then when the cover body 80 is rotated, the second sealing ring 93 will inevitably rub against the inner wall of the connector 37, which will greatly affect the closing of the cover body 80, so that the closing requires a greater force. Therefore, it is preferred that the cover body 80 and the second shell body 91 are detachably connected, or it is called a movable connection. For example, in this embodiment, a rotating portion 94 is provided at the upper end of the second shell body 91, and a first protrusion 95 is provided on the rotating portion 94. A connecting hole 81 is provided on the cover body 80. The rotating portion 94 can be inserted into the connecting hole 81 and buckled on the connecting hole 81 through the first protrusion 95, so that the second shell body 91 can rotate on the connecting hole 81. In this design, during the process of the cover body 80 covering the connecting head 37, due to the presence of the second sealing ring 93, the second shell body 91 will be equivalent to the up and down movement of the connecting head 37, and will hardly rotate. The second shell body 91 will be equivalent to the rotation of the cover body 80, which can make the covering of the cover body 80 easy. At the same time, the second sealing ring 93 can have a better effect in preventing leakage.

[0100] Protection components

[0101] The storage chamber 90 can be connected to the connector 37 through the cover 80. For example, in this embodiment, the cover 80 and the connector 37 are connected by threaded fitting. The cover 80 can be fixed to the connector 37 by gently turning the cover 80 a few times. However, since the number of turns of the cover 80 is not large, the cover 80 is easy to fall off from the connector 37. If the cover 80 is turned a few more times, the position of the storage chamber 90 cannot be seen clearly from the outside, and the sharp portion 38 is easy to pierce the sealing film 92. It is very difficult to find a position where the cover 80 will not fall off and the storage chamber 90 inside it will not be pierced. Even if such a position is found, it is easy for the tester to make a wrong operation if he is not clear about how to operate the detection device. For example, if the cover 80 is accidentally tightened before the test, the sealing film 92 is pierced, and then the buffer is released into the collection chamber 22. After entering the collection chamber 22, bacteria will grow after being exposed for a long time, and the metabolic products of the bacteria will change the pH value of the buffer, resulting in inaccurate test results.

[0102] In order to solve this technical problem, the detection device also includes a protective element 70, which is used to limit the cover body 80 from rotating excessively, that is, to limit the sharp portion 38 from piercing the storage cavity 90. The protective element 70 includes a support segment 71, which is sleeved on the connector 37, the lower end of the support segment 71 abuts against the upper surface of the cover end 31, and the upper end of the support segment 71 abuts against the cover body 80, so that the cover body 80 can be prevented from rotating excessively. The support segment 71 can be a hollow cylindrical shape, which can be sleeved on the connector 37. Further, when the support segment 71 is a hollow cylindrical shape, if the sharp portion 38 needs to pierce the storage cavity 90, the cover body 80 must be unscrewed first, the protective element 70 must be removed, and the cover body 80 must be tightened, which is too cumbersome. In this embodiment, a first notch 72 is provided on the supporting section 71 of the protective element 70. At the same time, the protective element 70 is elastic and can undergo elastic deformation. In this way, the protective element 70 can be directly removed without unscrewing the cover body 80, so that the cover body 80 can be directly rotated to puncture the storage cavity 90.

[0103] Preferably, in order to facilitate the removal of the protection element 70, the protection element 70 further includes a gripping portion 73, and the gripping portion 73 is provided with stripes, which can increase the friction between the inspector and the gripping portion 73. Furthermore, the gripping portion 73 is connected to the support section 71, and the connection position of the gripping portion 73 and the support section 71 is just opposite to the first notch 72.

[0104] Preferably, in order to make the protection element 70 installed more securely on the connecting head 37, the protection element 70 is provided with a second protrusion 44 protruding inward at the bottom position of the support section 71, and the second protrusion 44 can be annular. Correspondingly, the connecting head 37 is also provided with an annular structure 42 near the bottom position, and the second protrusion 44 can be inserted into the gap between the annular structure 42 and the upper surface of the covering end 31, so that the protection element 70 is securely installed.

[0105] Preferably, in order to make the detection device beautiful, the gripping portion 73 on the protection element 70 is positioned correctly rather than randomly oriented. A second notch 45 is provided on the annular structure 42, and correspondingly, a third protrusion 74 is provided on the inner side of the support section 71 of the protection element 70, which is opposite to the first notch 72. The third protrusion 74 can be embedded in the second notch 45, so that the rotation of the protection element 70 on the connector 37 can be limited. When the second notch 45 is located on the long side close to the covering end 31, the gripping portion 73 of the protection element 70 is also located on the long side close to the covering end 31, as shown in the attached figure. Figure 1 shown.

[0106] When the protection element 70 is installed on the connector 37, the support section 71 of the protection element 70 can prevent the cover 80 from being screwed in excessively, but cannot inhibit the cover 80 from being screwed out. If the cover 80 can still be screwed out after the protection element 70 is installed, the inspector will not know whether to remove the protection element 70 first or screw out the cover 80 first without knowing how to use the detection device. Preferably, a retaining wall 75 is provided on the support section 71 of the protection element 70. The retaining wall 75 corresponds to the shape of the support section 71 and is also arc-shaped. Since the cover 80 will be pressed on the upper end of the support section 71 during the use of the detection device, the inner diameter of the retaining wall 75 is slightly larger than the inner diameter of the support section 71. A buckle 76 is provided on the inner side of the retaining wall 75. Correspondingly, a circle of flanges 82 is provided at the bottom of the cover 80. The flange 82 of the cover 80 can enter the retaining wall 75 and be buckled under the buckle 76. Furthermore, the upper end of the flange 82 is horizontal, and the lower end surface of the buckle 76 is also horizontal. After the cover body 80 is installed, the upper end of the flange 82 abuts or nearly abuts the lower end surface of the buckle 76. At this time, if the inspector wants to unscrew the cover body 80, the flange 82 of the cover body 80 abuts against the buckle 76, and the buckle 76 drives the protection element 70 to move upward, and the second protrusion 44 of the protection element 70 is in a state of being buckled between the annular structure 42 and the cover end 31, so that the protection element 70 cannot complete the upward movement, so the cover body 80 cannot be unscrewed. Such a structural design allows the inspector to only pull out the protection element 70 when using the detection device. After pulling out the protection element 70, only the cover body 80 is left on the detection device. At this time, it is natural / easy for the inspector to release the buffer by rotating the cover body 80. The inspector does not need to know the use method of the detection device in advance. It is obvious to the inspector how to use the device for detection.

[0107] Preferably, the upper end of the buckle 76 is in the shape of an inclined plane, and the lower side of the flange 82 of the cover body 80 is provided with a chamfer 83. In this way, during the production and assembly of the detection device, the assembler first sets the protection element 70 on the connector 37, and matches the third protrusion 74 with the position of the second notch 45, and then screws the cover body 80 on the connector 37. During the downward movement of the cover body 80 (the second shell 91 has been installed inside the cover body 80), the chamfer 83 of the flange 82 abuts against the upper end surface (inclined surface) of the buckle 76. The downward movement of the cover body 80 can provide a horizontal force, which can slightly open the protection element 70 until the buckle 76 is buckled onto the flange 82 of the cover body 80. At this time, the cover body 80 is rotated in the opposite direction. Since the upper end of the flange 82 and the lower end surface of the buckle 76 are both horizontal planes, a horizontal force cannot be generated between them, and therefore the protection element 70 cannot be opened, thereby achieving the purpose of locking the cover body 80.

[0108] The above is only a specific implementation method of the invention, but the protection scope of the invention is not limited to it. Any changes or substitutions that are not conceived through creative work should be included in the protection scope of the invention. Therefore, the protection scope of the invention should be based on the protection scope defined in the claims.

[0109] The invention shown and described herein can be implemented in the absence of any element, limitation specifically disclosed herein. The terms and expressions used are used as illustrative terms rather than limiting, and it is not intended to exclude any equivalents of the features shown and described or parts thereof in the use of these terms and expressions, and it should be recognized that various modifications are feasible within the scope of the present invention. It should therefore be understood that, although the present invention is specifically disclosed through various embodiments and optional features, modifications and variations of the concepts described herein can be adopted by those of ordinary skill in the art, and it is believed that these modifications and variations fall within the scope of the present invention as defined in the appended claims.

[0110] The contents of the articles, patents, patent applications, and all other documents and electronically available information described or recorded herein are incorporated by reference in their entirety to the same extent as if each individual publication was specifically and individually indicated to be incorporated by reference. Applicants reserve the right to incorporate into this application any and all materials and information from any such article, patent, patent application, or other document.

Claims

1. A detection device, characterized in that: The device comprises a storage cavity, wherein an additive is contained in the storage cavity, and a sharp portion is contained in the detection device, wherein the storage cavity can move relative to the sharp portion, and during the movement of the storage cavity, the storage cavity is punctured by the sharp portion, thereby releasing the additive in the storage cavity; The detection device also includes a sample collector for collecting samples. A hole is provided on the sample collector and / or the collection chamber, and the hole enables the collection chamber to be gaseously connected to the outside. A hollow tube extending toward the collection chamber is provided at the hole position, and the hollow tube is constructed such that when the detection device is inverted, the height of the hole at the communication position is raised so that the hole cannot contact the liquid sample in the collection chamber. The detection device also includes a collection chamber, the released additive can enter the collection chamber, the collection chamber is used to accommodate the sample, the collection chamber is arranged in the first shell, and an opening is arranged at the upper side of the first shell; A testing element for detecting the substance to be analyzed is arranged in the collecting chamber.

2. A detection device according to claim 1, characterized in that: The test element is arranged on the carrier, and the carrier and the collection cavity have a specific matching form. The carrier can be inserted into the collection cavity from the opening at the upper side of the first shell, and has a definite and unique direction position after the carrier is inserted into the collection cavity.

3. A detection device according to claim 2, characterized in that: A clamping strip is arranged in the collecting chamber, and a carrier is fixed by two clamping strips. One side of the carrier on which the test element is mounted is in contact with one inner wall of the collecting chamber.

4. A detection device according to claim 3, characterized in that: The thickness of the upper end of the card strip is smaller, and the thickness of the lower end is larger; correspondingly, the thickness of the bottom position of the carrier is smaller, and the thickness of the top position of the carrier is larger.

5. A detection device according to claim 2, characterized in that: The corners of the collecting chamber are provided with rounded corners; correspondingly, the two sides of the carrier on which the test element is mounted are also provided with rounded corners.

6. A detection device according to claim 1, characterized in that: The sample collector comprises a covering end, which can be used to cover the opening of the collection chamber.

7. A detection device according to claim 1, characterized in that: The sample collector also includes a sampling end and a rod body. The sampling end is connected to the absorption element. The rod body is used to connect the covering end and the sampling end. The rod body is detachably connected to the covering end.

8. A detection device according to claim 1, characterized in that: The diameter of the hole is less than 1 mm.

9. A detection device according to claim 1, characterized in that: The additive in the storage chamber is a buffer.

10. A detection device according to claim 6, characterized in that: A connector is arranged on the side of the cover end of the sample collector facing away from the rod body. The interior of the connector is hollow, and the storage cavity can enter into the hollow position of the connector.

11. A detection device according to claim 10, characterized in that: The sharp portion is in a protruding shape and is arranged at a hollow position of the connector.

12. A detection device according to claim 11, characterized in that: The storage cavity is arranged in the second shell, and a sealing film is arranged on the second shell for sealing the additive in the storage cavity. The storage cavity enters into the hollow position of the connector, and the sharp part can pierce the sealing film on the second shell, thereby releasing the additive in the storage cavity.

13. A detection device according to claim 11, characterized in that: The sharp part is provided with a through hole which penetrates vertically.

14. A detection device according to claim 12, characterized in that: A second sealing ring is arranged on the second shell body, and the second sealing ring can fill the gap between the second shell body and the connecting head.

15. A detection device according to claim 12, characterized in that: The detection device also includes a cover body, which is connected to the second shell body. This connection relationship is detachable or non-detachable.

16. A detection device according to claim 15, characterized in that: The cover body and the connector can cover each other.

17. A detection device according to claim 16, characterized in that: The cover body and the connecting head are provided with matching threads.

18. A detection device according to claim 15, characterized in that: The cover body and the second shell have a rotating part at the upper end thereof, on which a first protrusion is disposed, and a connecting hole is disposed on the cover body. The rotating part can be inserted into the connecting hole and buckled on the connecting hole through the first protrusion, so that the second shell can rotate on the connecting hole.

19. A detection device according to claim 15, characterized in that: The detection device also includes a protection element for limiting excessive closing of the cover body.

20. A detection device according to claim 19, characterized in that: The protection element comprises a support section which is sleeved on the connecting head, the lower end of the support section can abut against the upper surface of the covering end, and the upper end of the support section can abut against the cover body.

21. A detection device according to claim 20, characterized in that: The supporting section is in the shape of a hollow cylinder and is sleeved on the connecting head.

22. A detection device according to claim 20, characterized in that: The supporting section of the protection element is provided with a first notch.

23. A detection device according to claim 19, characterized in that: The protective element is elastic.

24. A detection device according to claim 22, characterized in that: The protection element also includes a gripping portion, on which stripes are arranged, and the gripping portion is connected to the supporting section, and the connection position between the gripping portion and the supporting section is just opposite to the first notch.

25. A detection device according to claim 20, characterized in that: The protection element is provided with a second protrusion protruding inward at the bottom of the support section, and the second protrusion is annular. Correspondingly, the connecting head is also provided with an annular structure near the bottom, and the second protrusion can be inserted into the gap between the annular structure and the upper surface of the covering end.

26. A detection device according to claim 25, characterized in that: A second notch is provided on the annular structure, and correspondingly, a third protrusion is provided on the inner side of the supporting section of the protection element facing the first notch, and the third protrusion can be embedded in the second notch.

27. A detection device according to claim 26, characterized in that: The covering end is rectangular, and the second notch is located at a side close to the long side of the covering end.

28. A detection device according to claim 21, characterized in that: A retaining wall is arranged on the supporting section of the protection element, and the retaining wall is in an arc shape.

29. A detection device according to claim 28, characterized in that: The inner diameter of the protection element at the retaining wall position is greater than the inner diameter of the protection element at the supporting section position.

30. A detection device according to claim 28, characterized in that: A buckle is arranged on the inner side of the retaining wall, and a circle of flange is arranged at the bottom position of the cover body. The flange of the cover body can enter into the retaining wall and be buckled under the buckle.

31. A detection device according to claim 30, characterized in that: The upper end of the flange is horizontal, and the lower end surface of the buckle is also horizontal; the upper end of the buckle is inclined, and the lower side of the flange of the cover body is chamfered.

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