A minimally invasive cross-linking system for the posterior sclera

Abstract

The present invention relates to the field of medical device technology, specifically a posterior scleral minimally invasive cross-linking system. The system solves the current problem of lacking a scleral surgical instrument that can reduce the trauma of scleral surgery and prevent the spread of progressive myopia. The system includes a light source system, a liquid guide system, a telescopic system, a negative pressure system, a control system, and a positioning system. The light source system includes an ultraviolet array / blue light array light source or an ultraviolet / blue light electroluminescent material; the liquid guide system includes a liquid guide pump and a capillary controlled by a single-chip microcomputer to introduce liquid and a capillary for treating waste liquid; the telescopic system is controlled by a single-chip microcomputer to control a telescopic rod to achieve minimally invasive surgery; the negative pressure system is a ring tube and a three-way tube made of flexible material, which is used to draw vacuum to form a negative pressure state to prevent the leakage of reactants; the positioning system places an endoscope on the top layer of the membrane to achieve the positioning function of the minimally invasive instrument. The present invention has good flexibility, high degree of automation and safety, and can achieve minimally invasive operation when performing posterior scleral cross-linking method.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a posterior sclera minimally invasive cross-linking system. Background Art

[0002] High myopia is caused by excessive axial extension of the eye, which affects the outer layer of the eyeball, the sclera. The sclera protects the intraocular structures and determines the eye's ultimate shape and size. The sclera also serves as an anchor for the extraocular muscles and provides support for the ciliary muscle, which in turn assists in regulating the lens. Therefore, studying the sclera is a primary goal in therapeutic procedures to alleviate progressive myopia. Currently, scleral reinforcement surgery is the only clinically available option for mitigating scleral elongation. However, this procedure carries the risk of complications and is not ideally effective. Therefore, there is a need to develop a minimally invasive posterior scleral cross-linking system that can both reduce the degree of trauma associated with posterior scleral reinforcement surgery and effectively prevent the spread of progressive myopia. Summary of the Invention

[0003] The present invention aims to solve the technical problem of the current lack of a scleral surgical instrument that can reduce scleral surgical trauma and prevent the spread of progressive myopia, and provides a posterior scleral minimally invasive cross-linking system.

[0004] The present invention is implemented by adopting the following technical solutions: a minimally invasive posterior scleral cross-linking system, comprising a light source system, a liquid guide system, a telescopic system, a negative pressure system, a control system and a positioning system; the negative pressure system comprises a body with an opening at the bottom, a negative pressure ring installed around the inner edge of the body, an air extraction connection clamp and an air guide pump; the telescopic system is located inside the body and connects the front and back inner walls of the body; the negative pressure ring has an "n"-shaped cross section, and the negative pressure ring is annular but the two ends are not connected; two body outlets are respectively opened on the front side of the body, and the two ends of the negative pressure ring are respectively led out from the above two outlets. The air extraction connection clamp is a three-way tube, which is respectively connected to the two ports of the negative pressure ring and the air pump; a hole is opened in the middle of the telescopic system, and the light source system is installed on the top of the main body and is opposite to the hole in the middle of the telescopic system; the liquid guide system includes an inlet pipe and an outlet pipe and a liquid guide pump that can be connected to the inlet pipe and the outlet pipe, and the inlet pipe and the outlet pipe are respectively extended from the outside of the main body into the inside of the main body; the main body, the negative pressure ring and the inlet and outlet pipes are all made of deformable materials, and the positioning system is integrated on the light source system; the control system is connected to the light source system, the telescopic system, the positioning system, the air pump and the liquid guide pump.

[0005] The telescopic system enables the main body structure to be extended and retracted, thus achieving minimally invasive surgery. By extending the telescopic system, the main body becomes slender. At this point, the positioning system is first used to position the entire system. The slender main body is placed in the area of ​​the sclera to be cross-linked. The telescopic system contracts to restore the main body to its working state. The air pump is turned on to allow the negative pressure ring to adhere to the sclera. The infusion function of the liquid pump is activated, and liquid is introduced into the main body through the liquid inlet tube and brought into contact with the cross-linked area. The light source system is turned on for irradiation cross-linking. After cross-linking is completed, the light source is turned off, the liquid pump is turned on, and the waste liquid is pumped out through the liquid outlet tube, completing cross-linking. A cleaning liquid is then introduced into the main body through the liquid pump. After cleaning is complete, the liquid pump is turned on to pump out the waste liquid.

[0006] Furthermore, the light source system can be made into a UVA / BLUE LED array, with UVA preferably having 370nm purple light and BLUE preferably having 445nm blue light, or an organic electroluminescent material that can emit the corresponding wavelength can be selected as the light source; the positioning system is installed in the gap between the LED array or the fluorescent film to facilitate observation of the sclera and positioning of the body.

[0007] Furthermore, the control system is designed through single chip microcomputer programming to establish a system model, thereby realizing numerical control.

[0008] Furthermore, the negative pressure system uses a ring tube (with an n-shaped cross section) and a three-way tube made of flexible material to draw a vacuum to form a negative pressure state, so as to prevent the reactants from leaking out.

[0009] Furthermore, the telescopic system: a telescopic rod is used in conjunction with a single-chip microcomputer to realize the telescopic structure of the mechanical structure, thereby achieving minimally invasive surgery.

[0010] Furthermore, the positioning system uses an implanted endoscope and a neural network-based image processing algorithm to achieve accurate positioning at the posterior pole of the sclera.

[0011] Furthermore, the negative pressure ring, the liquid guiding system and the control system are integrated.

[0012] The specific size of the posterior sclera minimally invasive cross-linking system is approximately 10*7*5mm, and the size after expansion and contraction is approximately 5*14*5mm.

[0013] Based on the minimally invasive posterior sclera cross-linking system provided by the present invention, a method for cross-linking using the minimally invasive posterior sclera cross-linking system can be implemented, and photochemical cross-linking and chemical cross-linking can be performed.

[0014] Chemical cross-linking part: Generally, formaldehyde sustained-release preservatives (FARs), glyceraldehyde, glutaraldehyde, nitro alcohols, genipin and other chemical cross-linking agents are flowed into the cross-linking area through a liquid guide pump. The negative pressure ring is vacuum-evacuated and fits tightly to the scleral tissue to prevent the chemical cross-linking agent from flowing out. After the reaction is completed, the waste liquid is recovered through the capillary on the other side of the liquid guide pump.

[0015] Photochemical Cross-linking: The mechanism of CXL is the generation of singlet oxygen when riboflavin is irradiated by UVA / BLUE light. This singlet oxygen then oxidizes collagen to form covalent cross-links. Since riboflavin has two secondary absorption peaks, around 445nm and 370nm, blue and violet light cross-linking can be used. Riboflavin is first introduced into the cross-linking area via a liquid pump. A vacuum ring is then applied to the sclera, tightly fitting the riboflavin to prevent it from escaping. The LED array or electroluminescent material is then energized to produce photochemical cross-links. Once the reaction is complete, waste liquid is recovered through the capillary on the other side of the liquid pump. The self-cleaning function is then activated to clean the cross-linking area, dilute any remaining liquid, and drain the solution.

[0016] Advantages of the present invention:

[0017] 1. The present invention provides a minimally invasive cross-linking system for the posterior sclera, comprising a light source system, a liquid guide system (including a self-cleaning system), a telescopic system, a negative pressure system, a control system, and a positioning system. The telescopic system can achieve cross-linking at the posterior sclera with a smaller wound, resulting in less damage. Specifically, the present invention can effectively place the telescopic rod in the cross-linking area in a retracted state, and then change the length of the telescopic rod by adjusting the program so that the cross-linking system is programmed into a layered structure to achieve regional cross-linking. This method can effectively reduce the size of the wound required in the conjunctival area when the device is inserted into the posterior sclera. At the same time, the negative pressure ring can form a negative pressure state when the air is pumped out. By utilizing the negative pressure state, the negative pressure ring can be tightly attached to the eyeball treatment area to prevent the outflow of the cross-linking reagent. At this time, (1) chemical cross-linking can be performed directly, and after the cross-linking is completed, the waste liquid can be discharged through the capillary (liquid outlet tube) on the other side of the liquid guide pump. (2) By adjusting the appropriate light power to be sufficient to cure the cross-linked drug through the LED array or electro-ultraviolet fluorescent material, the treated part of the eyeball is photochemically cross-linked. After the cross-linking is completed, gas is introduced into the negative pressure ring to release the negative pressure, thereby facilitating the removal of the entire device and completing the cross-linking operation. Therefore, the device of the present invention can increase the hardness of the posterior pole of the sclera to control the growth of the eye axis and prevent myopia.

[0018] 2. The negative pressure ring used in the present invention is made of flexible material. When it is fixed to the posterior sclera under negative pressure or when it is removed, it will not damage the eyeball or intraocular tissue. The telescopic rod is used to realize the telescopic transformation of the entire instrument, thereby achieving minimally invasive surgery without cutting the extraocular muscles.

[0019] 3. The present invention provides a minimally invasive cross-linking system for the posterior sclera. The negative pressure ring has a groove in a normal state. When in use, the groove of the negative pressure ring is placed toward the posterior sclera tissue, and air is pumped to change the negative pressure ring into a negative pressure state, so that it is tightly attached to the sclera to form an enclosed space, thereby preventing the cross-linking reagent from flowing out and contaminating other positions.

[0020] 4. Use LED arrays or organic electroluminescent UV / blue fluorescent materials to achieve uniform irradiation in the cross-linked area.

[0021] 5. Place the ophthalmic endoscope system in the system to achieve the positioning effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 Schematic diagram from above of the minimally invasive posterior scleral cross-linking system.

[0023] Figure 2 Schematic diagram of the exhaust connection clamp structure.

[0024] Figure 3 Bird's-eye view of the minimally invasive posterior scleral cross-linking system.

[0025] Figure 4 Cross-section diagram of the negative pressure system.

[0026] Figure 5 for Figure 4 BB cross-sectional view.

[0027] Figure 6 Front view of the negative pressure system.

[0028] Figure 7 Cross-section of the minimally invasive posterior scleral cross-linking system.

[0029] Figure 8 for Figure 7 AA cross-sectional view.

[0030] Figure 9 Front view of the minimally invasive posterior scleral cross-linking system.

[0031] Figure 10 Schematic diagram of the minimally invasive posterior scleral cross-linking system.

[0032] Figure 11 Axial view of the front end of the telescopic rod.

[0033] Figure 12 Schematic diagram of the main structure of the telescopic rod.

[0034] Figure 13 Schematic diagram of the three-dimensional structure of the telescopic rod.

[0035] Figure 14 Schematic diagram of the telescopic rod structure from a bottom view.

[0036] Figure 15 for Figure 14 CC cross-sectional view.

[0037] 1- LED array, 2- telescopic rod, 3- positioning system, 4- main body, 5- negative pressure ring, 6- vacuum connection clamp, 7- liquid inlet pipe, 8- liquid outlet pipe, 9- main body outlet, 10- liquid inlet pipe opening, 11- liquid outlet pipe opening;

[0038] 21-cylindrical segment, 22-annular segment, 23-spring. DETAILED DESCRIPTION

[0039] Example 1

[0040] A minimally invasive posterior scleral cross-linking system, comprising a light source system, a fluid guide system, a telescopic system, a negative pressure system, a control system, and a positioning system 3; the negative pressure system comprises a body 4 with an opening at the bottom, a negative pressure ring 5 installed around the inner edge of the body 4, an air extraction connection clamp 6, and an air guide pump; the telescopic system is located inside the body 4 and connects the front and rear inner walls of the body 4; the negative pressure ring 5 has an "n"-shaped cross section, and the negative pressure ring 5 is annular but the two ends are not connected; two body outlets are respectively opened on the front side of the body 4, and the two ends of the negative pressure ring 5 are respectively led out from the above two outlets, and the air extraction connection clamp 6 is a three-way intersection tubes, respectively connected to the two ports of the negative pressure ring 5 and the air pump; a hole is opened in the middle of the telescopic system, and the light source system is installed on the top of the main body 4 and is opposite to the hole in the middle of the telescopic system; the liquid guide system includes an inlet pipe 7 and an outlet pipe 8 and a liquid guide pump that can be connected to the inlet pipe 7 and the outlet pipe 8, and the inlet pipe 7 and the outlet pipe 8 are respectively extended from the outside of the main body 2 into the inside of the main body 2; the main body 2, the negative pressure ring 5 and the inlet and outlet pipes are all made of deformable materials, and the positioning system 3 is integrated on the light source system; the control system is connected to the light source system, the telescopic system, the positioning system 3, the air pump and the liquid guide pump.

[0041] Example 2

[0042] like Figure 3 As shown, the main body 4 has the shape of a hollow small ball table structure (or similar to a bowl or lid) with an opening facing downward and a fixed ring connected to the bottom of the small ball table; the negative pressure ring 5 is installed close to the inner wall of the fixed ring; the telescopic system is installed on the front and rear inner walls of the fixed ring; the light source system is suspended on the top of the small ball table through a bracket.

[0043] Example 3

[0044] The light source system utilizes a UV / blue LED array 1 or a UV / blue fluorescent film made of organic electroluminescent material; the UV wavelength is 370nm and the blue wavelength is 445nm. The positioning system 3 is installed in the gap between the LED array 1 or the fluorescent film. The telescopic system consists of two parallel telescopic rods 2 spaced a certain distance apart, with the light source system corresponding to the gap between the two telescopic rods 2.

[0045] Example 4

[0046] The port of the liquid inlet pipe 7 extending into the interior of the body is located at a high position inside the body 4; the liquid outlet pipe 8 extends into the rear of the body 4 and is located at a low position inside the body 4; both the liquid inlet and liquid outlet pipes extend into the body from the side wall above the two outlets on the front side of the body 4. Figure 1 In the pump, one inlet tube extends into the front of the main body, while the other outlet tube is located at the rear, making it easier to pump out the liquid inside. When the air and liquid pumps are powered by a peristaltic pump, the main body 4, negative pressure ring 5, and inlet / outlet tubes are made of flexible materials (polydimethylsiloxane (PDMS) or polyurethane (PU)). When the air and liquid pumps are powered by a syringe pump, the main body 4, negative pressure ring 5, and inlet / outlet tubes are made of rigid tubing.

[0047] The control system uses a single chip microcomputer; the positioning system 3 is an endoscope. The light source system, the telescopic system and the positioning system 3 are all led out from the inside of the body 4 through lead wires and connected to the control system.

[0048] As attached Figure 1 As shown, a minimally invasive posterior scleral cross-linking system includes a light source system, a fluid guide system (including a self-cleaning system), a telescoping system, a negative pressure system, a control system, and a positioning system. The present invention offers excellent flexibility, a high degree of automation, and high safety, enabling minimally invasive procedures during posterior scleral cross-linking.

[0049] The position distribution of the light source system is as shown in the attached Figure 1 、 7 As shown in , 8 and 9, it includes a UVA / BLUE LED array 1, or an OLED fluorescent film made of organic electroluminescent material.

[0050] The position distribution of the liquid guiding system is as shown in the attached Figure 7 As shown, point 7 is the inlet of the liquid inlet tube, and is located at the top of the device. Since the sclera is angled after the system is implanted, the liquid flowing in from point 7 can completely infiltrate the sclera. Point 8 is the liquid outlet, which is located at the bottom of the device and can discharge the residual liquid after the reaction. The self-cleaning system replaces the liquid medicine with cleaning liquid.

[0051] The specific location of the telescopic system is as shown in the attached Figure 7 、 8As shown, the extension of the telescopic rod 2 can be controlled to adjust the size of the posterior scleral minimally invasive cross-linking system to achieve minimally invasive surgery. The specific transformation process is shown in the attached figure. Figure 10 The specific dimensions of the posterior sclera minimally invasive cross-linking system are approximately 10*7*5 mm, and after the telescopic transformation (elongated state), the dimensions are approximately 5*14*5 mm, i.e., elongated in the front-to-back direction.

[0052] like Figure 11-15 As shown, the telescopic rod 2 consists of a cylindrical section 21, an annular section 22 fixed to the front end of the cylindrical section 21, and a spring 23 nested in the annular section 22; the front end of the spring 23 is fixedly connected to the inner wall of the front end of the annular section 22; the front end of the annular section 22 is connected to the front part of the inner wall of the body 4, the end of the cylindrical section 21 is connected to the rear part of the inner wall of the body 4, and the annular section 22 is connected to an external pneumatic pump via an air guide tube extending from the outer wall of the body 4 into the interior of the body 4; the cylindrical section 21 of the telescopic rod 2 is made of a two-component PDMS material A liquid (dimethyl silicone oil) and B liquid (curing agent) in a mass ratio of 1:5 and cured at 100°C; the annular section 22 of the telescopic section is made of a two-component PDMS material A liquid (dimethyl silicone oil) and B liquid (curing agent) in a mass ratio of 1:10 and cured at 70°C; through the pneumatic pump, gas is injected to push the annular section and the spring to deform, thereby achieving the purpose of linear deformation of the telescopic rod and realizing the telescopic function.

[0053] The negative pressure system is attached Figure 3 The vacuum connection clip is connected to the external air pump to make the negative pressure ring present a vacuum state, firmly attached to the sclera, and control the drug solution from leaking out. Its specific structure is shown in the attached figure. Figure 4 、 5 , as shown in 6.

[0054] The control system is composed of an external single-chip microcomputer unit and is connected to a host computer to achieve precise control.

[0055] The positioning system uses an endoscope installed in the body, the endoscope feeds back images, and the ophthalmologist performs the positioning operation to realize the positioning function of the minimally invasive instrument.

[0056] The method of using the present invention in the posterior scleral cross-linking method (photochemical cross-linking part) is as follows:

[0057] (1) Before use, ensure that the capillary tube is connected to the liquid pump controlled by the microcontroller, the negative pressure ring is connected to the air pump, the LED array wires are connected to the microcontroller, and the endoscope is fixed to the front end. Cut the conjunctiva and separate the subconjunctival tissue and Tenon's capsule.

[0058] (2) After the clinician determines the most suitable scleral area for irradiation based on the location and extent of the patient's posterior scleral staphyloma, the first configuration of the cross-linking system is used, with the telescopic rod in the extended extreme position, and the entire cross-linking system in an extended state. The cross-linking system of the present invention is inserted under the Tenon's capsule using tweezers, and the endoscope on the front side of the cross-linking system is used to adjust the target area of ​​the sclera to be irradiated by the LED array. Then, through the control system of the single-chip microcomputer, the telescopic rod is retracted by computer input commands, and the entire cross-linking system assumes a surface layer structure, greatly increasing the cross-linking area.

[0059] (3) After positioning is completed, the negative pressure ring is evacuated to form negative pressure and fixed at the cross-linking site to prevent chemical reagents such as riboflavin from leaking out.

[0060] (4) Using a single-chip microcomputer system, the liquid guide system continuously and evenly dispenses riboflavin solution at a fixed speed, pushing it into the main body of the cross-linker through the capillary tube. Finally, 0.1% riboflavin solution is inserted through the capillary tube under the Tenon's capsule and infiltrates the posterior sclera for about 30 minutes, allowing the riboflavin solution to continuously infiltrate the targeted sclera area, preparing for the next step of scleral cross-linking.

[0061] (5) Irradiate the cross-linked posterior sclera region using a uniform and single UVA / BLUE LED array or energize the electro-UVA / BLUE fluorescent material to generate a uniform and single UVA / BLUE light beam to irradiate the cross-linked region. After the highly permeable riboflavin solution has fully infiltrated the cross-linked sclera region, irradiate the cross-linked sclera region with UVA / BLUE light beams emitted by the LED array light source or electro-UVA / BLUE fluorescent material to fully activate the riboflavin photosensitizer and achieve cross-linking in the posterior sclera region.

[0062] (6) After the cross-linking reaction is completed, the outlet function of the liquid guide pump is turned on to discharge the waste liquid after the reaction through the capillary on the other side.

[0063] (7) After draining the waste liquid, remove the liquid medicine tube and replace it with a cleaning liquid tube. Use the liquid guide pump of the liquid guide system to introduce the cleaning liquid, soak it for a while, and then drain the waste liquid through the drainage function of the liquid guide pump.

[0064] (8) Inject gas into the negative pressure ring to release the negative pressure, remove the cross-linker, and suture the conjunctival wound.

Claims

1. A minimally invasive cross-linking system for the posterior sclera, characterized in that: The invention comprises a light source system, a liquid guiding system, a telescopic system, a negative pressure system, a control system and a positioning system (3); the negative pressure system comprises a body (4) with a bottom opening, a negative pressure ring (5) installed around the inner edge of the body (4), an air extraction connection clamp (6) and an air guide pump; the telescopic system is located inside the body (4) and is connected to the front and rear inner walls of the body (4); the cross section of the negative pressure ring (5) is "n" shaped, and the negative pressure ring (5) is annular but the two ends are not connected; two body outlets (9) are respectively opened on the front side of the body (4), and the two ends of the negative pressure ring (5) are respectively led out from the above two outlets, and the air extraction connection clamp (6) is a three-way pipe, which is connected to the negative pressure ring (9) and the negative pressure ring (9) respectively. Two ports of the pressure ring (5) and an air pump; a hole is opened in the middle of the telescopic system, and the light source system is installed on the top of the body (4) and is opposite to the hole in the middle of the telescopic system; the liquid guide system includes a liquid inlet pipe (7) and a liquid outlet pipe (8) and a liquid guide pump that can be connected to the liquid inlet pipe (7) and the liquid outlet pipe (8), and the liquid inlet pipe (7) and the liquid outlet pipe (8) are respectively extended from the outside of the body (4) into the inside of the body (4); the body (4), the negative pressure ring (5) and the liquid inlet and outlet pipes are all made of deformable materials, and the positioning system (3) is integrated on the light source system; the control system is connected to the light source system, the telescopic system, the positioning system (3), the air pump and the liquid guide pump.

2. The minimally invasive posterior sclera cross-linking system according to claim 1, characterized in that: The main body (4) has an outer shape of a hollow small ball table structure with an opening facing downward, and a fixing ring is connected below the circumference of the small ball table; the negative pressure ring (5) is installed closely against the inner wall of the fixing ring; the telescopic system is installed on the front and rear inner walls of the fixing ring; and the light source system is suspended on the top of the small ball table through a bracket.

3. The minimally invasive cross-linking system for the posterior sclera according to claim 1, wherein: The light source system adopts an ultraviolet / blue light LED array (1) or an ultraviolet / blue light fluorescent film made of an organic electroluminescent material; the positioning system (3) is installed in the gap between the LED array (1) or the fluorescent film.

4. The minimally invasive cross-linking system for the posterior sclera according to claim 3, characterized in that: The wavelength of violet light is 370nm and the wavelength of blue light is 445nm.

5. The minimally invasive posterior sclera cross-linking system according to claim 2, wherein: The telescopic system is composed of two telescopic rods (2) that are spaced a certain distance apart and parallel to each other, and the light source system corresponds to the distance between the two telescopic rods (2).

6. The minimally invasive cross-linking system for the posterior sclera according to claim 5, characterized in that: The telescopic rod (2) is composed of a cylindrical section (21), a circular ring section (22) fixed to the front end of the cylindrical section (21), and a spring (23) nested in the circular ring section (22); the front end of the spring (23) is fixedly connected to the inner wall of the front end of the circular ring section (22); the front end of the circular ring section (22) is connected to the front part of the inner wall of the body (4), the end of the cylindrical section (21) is connected to the rear part of the inner wall of the body (4), and the circular ring section (22) is connected to an external pneumatic pump through an air guide tube extending from the outer wall of the body (4) into the interior of the body (4).

7. The minimally invasive posterior sclera cross-linking system according to claim 6, characterized in that: The cylindrical section (21) of the telescopic rod (2) is made of a two-component PDMS material A liquid and a two-component PDMS material B liquid in a mass ratio of 1:5 and cured at 100°C; the annular section (22) is made of a two-component PDMS material A liquid and a two-component PDMS material B liquid in a mass ratio of 1:10 and cured at 70°C.

8. The minimally invasive cross-linking system for the posterior sclera according to any one of claims 1 to 7, characterized in that: The port of the liquid inlet pipe (7) extending into the interior of the body is located at a high position inside the body (4); the liquid outlet pipe (8) is located at a low position inside the body (4) after extending into the interior of the body (4); the liquid inlet / outlet pipes extend into the interior of the body (4) from the side wall of the body (4) above the two outlets on the front side of the body (4), respectively.

9. The minimally invasive posterior sclera cross-linking system according to any one of claims 1 to 7, characterized in that: The control system adopts a single chip microcomputer; the positioning system (3) is an endoscope; the light source system, the telescopic system and the positioning system (3) are all led out from the inside of the body (4) through lead wires and connected to the control system.

10. The minimally invasive cross-linking system for the posterior sclera according to any one of claims 1 to 7, characterized in that: When the air guide pump and the liquid guide pump use a peristaltic pump as a power source, the body (4), the negative pressure ring (5), and the inlet / outlet pipes are made of flexible materials; when the liquid guide pump uses a syringe pump, the inlet / outlet pipes are made of hard pipe materials.

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