A detection device

Abstract

The present invention relates to the field of medical testing instruments, and in particular to a testing device. Existing tests mostly use separate parts and are operated separately, which makes samples easily contaminated. Single-tube designs that combine sampling and testing have low production efficiency and the possibility of leakage. A testing device is provided, which includes a testing tube and a sample storage tube that are independently arranged and connected to the internal cavity through a connecting cavity. Each part of the device is produced independently, with high efficiency, and has good development prospects in the field of medical testing instrument technology.

Description

Technical Field

[0001] The present invention relates to the field of medical detection tools, and in particular to a detection device. Background Art

[0002] As a mature in vitro diagnostic test technology, immunocolloidal gold labeling technology has been widely used because of its advantages of rapidity, simple and convenient operation, and accurate results. It has played a significant role in the detection of infectious viruses, such as the new coronavirus and influenza.

[0003] Most of the existing immunocolloidal gold labeling technology tests on the market use three independent parts: a sampling cotton swab, a buffer liquid tube, and a reagent plate. When in use, a sampling cotton swab must be used to collect a sample from the subject's nasal cavity or oral cavity. After collecting the sample, the cotton swab is placed in the buffer liquid tube to dissolve the reaction and extract the test sample. After standing for a period of time, a dropper is used to transfer the sample in the buffer liquid tube to the reagent strip in the reagent plate. After standing for a certain period of time, when the reaction liquid dripped into the reagent strip passes through the capillary on the reagent strip and reaches the antibody area of the reagent strip, the antigen in the sample will combine with the antibody in the area, causing the area to display a certain color, namely the C line and T line, thereby showing the C line and T line. The test results are inaccurate if the sample is contaminated by the external environment. If the sample liquid is spilled during use, it may even expose the sample containing infectious pathogens to the environment, causing secondary infection and putting the user in danger. If the cotton swab is discarded at will and the sample of the person being tested happens to be infectious, it is very easy to cause secondary infection of the infectious disease and spread in society.

[0004] Chinese utility model patent CN 214278200 U discloses a fully sealed, pre-pressurized, integrated medical tube for sampling, storage, and detection, which includes a tube body, an upper cover and a base respectively installed at the upper and lower openings of the tube body. The tube body has a main cavity connected to the upper opening of the tube body, a bottom cavity arranged at the lower opening of the tube body, and a detection cavity connected to the bottom cavity. The main cavity forms a sealed space through the sealing of the upper cover, and the bottom cavity forms a sealed space connected to the detection cavity through the sealing of the base. A push piece is installed in the base, and the push piece has a push rod corresponding to the bottom surface of the main cavity. Under the action of external force, the push rod of the push piece pierces the bottom surface of the main cavity, allowing the main cavity to communicate with the bottom cavity.

[0005] The above-mentioned utility model integrates the entire sampling, sample storage and testing into one, overcoming the risk of secondary infection. However, the single-tube design requires overall production and filling, which has low production efficiency and the possibility of internal leakage causing the test strip to fail. Therefore, a new detection device is designed to solve the above problems. Summary of the Invention

[0006] In order to solve the above technical problems, the purpose of the present invention is to provide a detection device that solves the problems of internal leakage and low production efficiency in existing reagent tube designs.

[0007] In order to achieve the above object, the technical solution adopted by the present invention is:

[0008] A detection device comprises a sample storage tube and a detection tube which are independently arranged. The sample storage tube and the detection tube are connected to an internal cavity through a connecting cavity.

[0009] By adopting the above technical solution, the sample storage tube is filled with storage liquid in advance before use, and the test tube is placed in advance with a reagent strip. The test tube and sample storage tube, which are independently arranged, can be processed and produced separately without affecting each other. The filling of storage liquid and the placement of reagent strips do not require a sequence, thereby improving production efficiency; at the same time, the probability of internal leakage of a single tube cavity during production causing the test strip to fail is reduced.

[0010] Furthermore, the inner cavity of the sample storage tube is in an inverted cone shape.

[0011] The buffer liquid in the sample storage tube has corresponding elevation requirements, so that the sampling cotton swab can be completely and fully immersed. By adopting the above technical solution, the elevation requirements can be met with less buffer liquid, and the concentration of the sampling specimen can be guaranteed to meet the standard.

[0012] Furthermore, the communicating cavity is a stepped pipe structure.

[0013] By adopting the above technical solution, the stepped bend of the connecting cavity extends the connection path between the detection tube and the sample storage tube. When the storage liquid flows from the sample storage tube to the detection tube, it needs to pass through the bend, thereby reducing the probability of the test strip failing due to the storage liquid that has not combined with the sample entering the detection tube prematurely.

[0014] Furthermore, a sealing structure is provided in the communicating cavity, and the sealing structure is movably matched with the communicating cavity.

[0015] By adopting the above technical solution, in the initial state, the sealing structure blocks the connecting cavity, and the inner cavities of the detection tube and the sample storage tube are independent and not connected. In the use state, the sealing structure moves, and the internal cavities of the detection tube and the sample storage tube are connected through the connecting cavity. The sealing structure changes the state of the connecting cavity by moving, avoiding violent damage, reducing pollution caused by liquid leakage in the device, and improving safety.

[0016] Furthermore, a fixed structure is provided in the detection tube, the fixed structure is movably connected to the detection tube, and the fixed structure includes a main body.

[0017] By adopting the above technical solution, the reagent strip is installed on the main body of the fixed structure. The material of the reagent strip is relatively soft and easy to bend and damage. The main body provides support for the reagent strip. In addition, the reagent strip is installed on the fixed structure after production and delivery. If the reagent strip in the test tube is used to detect disease A at the time of delivery, it needs to be temporarily replaced to detect disease B later. The fixed structure movably connected to the test tube can be taken out and the reagent strip can be replaced accordingly. That is, standard production can be planned in advance, and temporary emergency supplements can be made due to temporary plan adjustments.

[0018] Furthermore, a fixing structure is provided in the detection tube, and a guiding structure is provided between the fixing structure and the detection tube.

[0019] By adopting the above technical solution, it plays a guiding and limiting role when the fixed structure is installed, preventing the fixed structure from falling off or moving.

[0020] Furthermore, a latch is provided on one side of the main body, and an anti-overflow plate is provided near the connection port between the main body and the detection tube, and the anti-overflow plate is located on the side of the main body where the latch is not provided.

[0021] By adopting the above technical solution, the reagent strip is installed on one side of the main body and is strengthened and fixed by the latch to prevent it from falling off. The anti-overflow plate is located on the back of the main body where the reagent strip is installed. On the one hand, it can prevent the storage liquid from flowing into the detection tube in large quantities and infecting the non-detection point part of the reagent strip, causing the reagent strip to fail. On the other hand, it does not affect the contact between the reagent strip and the storage liquid with the sample.

[0022] Furthermore, the communicating cavity is arranged in a base, the base is located at the bottom of the device, and the communicating cavity includes a first channel, a second channel and a third channel that are connected in sequence.

[0023] By adopting the above technical solution, the buffer liquid flows at the bottom of the device, which can reduce the use of the buffer liquid.

[0024] Furthermore, the detection device includes a pushing piece, which is detachably connected to the detection device through a connecting structure. The connecting structure includes a limiting boss, a limiting flange and a flange fixing foot provided on the detection device. The limiting boss, the limiting flange and the flange fixing foot are rotatably matched, and a fixing strip is provided in the flange fixing foot.

[0025] By adopting the above technical solution, the pushing member can be removed from the device by rotating it for use.

[0026] Furthermore, the sealing structure includes a sealing component and a push rod, and the sealing component includes an inner sealing component and an outer sealing component respectively arranged at both ends of the push rod.

[0027] By adopting the above technical solution, in the initial state, the inner sealing component and the outer sealing component are located at both ends of the connection port between the sample detection tube and the communicating cavity to achieve sealing. Driven by the push rod, the inner sealing component moves to the connection port between the communicating cavity and the detection tube and connects the detection tube with the internal cavity of the sample storage tube. The outer sealing structure always plays a role in sealing and preventing liquid leakage.

[0028] Compared with the prior art, the advantages of the present invention are: 1. The independent double-tube integrated connecting cavity structure design improves production efficiency and reduces the probability of premature damage to the reagent strip due to leakage in the tube. It adopts a fully sealed form. After sample collection, the sampling cotton swab can be directly sealed in the cache tube body, avoiding the discard of the sampling cotton swab, reducing environmental pollution, and avoiding the risk of secondary transmission; 2. The stepped connecting cavity cooperates with the sealing structure to achieve the purpose of blocking the flow of cache liquid in the early stage. When in use, the sample storage tube is connected to the internal space of the detection tube by moving the sealing structure to ensure good sealing; 3. Through the sample extraction structure and the inverted cone cavity structure in the sample storage tube, the use of cache liquid is reduced and the sample concentration is guaranteed; 4. The reagent strip in the device structure can be replaced and adjusted accordingly according to the disease to be detected, with a wide range of applications; 5. Improve the control level and ease of use of infectious disease prevention and control. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 It is a schematic diagram of the front cross-sectional structure of the present invention in the initial state.

[0030] Figure 2 It is a schematic diagram of the front cross-sectional structure of the present invention when it is in use.

[0031] Figure 3 It is a schematic diagram of the cross-sectional structure of the present invention in the initial state.

[0032] Figure 4 It is a schematic diagram of the cross-sectional structure when the present invention is in use.

[0033] Figure 5It is a schematic diagram of the three-dimensional structure of the present invention.

[0034] Figure 6 It is a schematic diagram of the three-dimensional explosion structure of the present invention.

[0035] Figure 7 It is a schematic diagram of the structure of the base of the present invention when viewed from above.

[0036] Figure 8 It is a schematic diagram of the front structure of the fixing structure of the present invention.

[0037] Figure 9 It is a schematic diagram of the back structure of the fixing structure of the present invention.

[0038] In the figure: 1. Base, 1-1. Fixing bar, 1-2. Flange fixing foot, 1-3. Connecting cavity, 1-3-1. First channel, 1-3-2. Second channel, 1-3-3. Third channel, 2. Detection tube, 2-1. Guide bar, 2-2. Inner cavity of detection tube, 3. Fixing structure, 3-1. Main body, 3-2. Reagent strip, 3-3. Guide groove, 3-1-1. Gear, 3-1-2. Air vent, 3-1-3. Anti-overflow tray, 4. Sealing cover, 5. Sample storage tube, 5-1. Ridge, 5-2. Inner cavity of sample storage tube, 6. Sealing structure, 6-1. Push rod, 6-2-1. Inner sealing assembly, 6-2-2. Outer sealing assembly, 7. Push member, 7-1. Limiting boss, 7-2. Limiting flange. DETAILED DESCRIPTION

[0039] The present invention will be described in further detail below with reference to the accompanying drawings and embodiments.

[0040] Example 1: By Figures 1 to 5 A detection device is provided, which includes a base 1, a detection tube 2 and a sample storage tube 5. A connecting cavity 1-3 is set in the base 1, and the detection tube 2 and the sample storage tube 5 are independently arranged and installed through the base 1. The base 1 is located below the device, and the sample storage tube inner cavity 5-2 and the detection tube inner cavity 2-2 are connected through the connecting cavity 1-3, which can reduce the use of buffer liquid. A visual window is set on the detection tube 2, and the visual window can be a partial transparent tube on the detection tube 2 through which the C line and T line on the reagent strip can be observed, or the detection tube can be made into a transparent tube as a whole. A sealing cover 4 is set on the top of the sample storage tube 5, and the sealing cover 4 is movably connected to the sample storage tube 5 through a threaded structure. A sealing ring is set in the sealing cover 4 to strengthen the seal, and a movable sealing structure 6 is set in the connecting cavity 1-3, which integrates sampling, detection and viewing of test results.

[0041] Example 2: Based on Example 1, the buffer liquid in the sample storage tube has a corresponding elevation requirement, so that the sampling cotton swab can be completely and fully immersed. The internal cavity of the sample storage tube is in an inverted cone shape, and less buffer liquid can be used to meet the elevation requirement while ensuring that the concentration of the sampled specimen meets the standard. In addition, the inverted cone-shaped cavity structure will, to a certain extent, squeeze the cotton swab used for sampling, so that more samples are dissolved in the buffer liquid. A sample extraction structure is provided in the sample storage tube 5, and the sample extraction structure can be a plurality of ridges 5-1 provided on the inner wall of the sample storage tube 5. After the sample is extracted, it sticks to the sampling cotton swab and rubs back and forth on the ridges 5-1, which increases the friction resistance, so that the sample on the sampling cotton swab can be fully dissolved in the buffer liquid, achieving a qualified test specimen density, and thus obtaining accurate test results.

[0042] Example 3, based on Example 1, the connecting cavity 1-3 is a stepped cavity structure, the connecting cavity 1-3 includes a first channel 1-3-1, a second channel 1-3-2 and a third channel 1-3-3 that are connected in sequence, the first channel 1-3-1 is connected to the sample storage tube 5, the third channel 1-3-3 is connected to the detection tube 2, the sealing structure 6 is movably arranged in the first channel, the sealing structure 6 includes a push rod 6-1 and an inner sealing component 6-2-1 and an outer sealing component 6-2-2 respectively installed at both ends of the push rod 6-1, the inner sealing component is located at one end of the push rod 6-1 close to the second channel, and the sealing structure 6 simultaneously meets the following requirements: 1. There is a buffered liquid flow between the push rod 6-1 and the sealing component. 2. In the initial state, the inner sealing component 6-2-1 and the outer sealing component 6-2-2 are respectively located on both sides of the connection port between the connecting cavity 1-3 and the sample storage tube 5. The outer sealing component 6-2-2 is used to prevent the storage liquid from overflowing, and the inner sealing component 6-2-1 is used to prevent the storage liquid from flowing into the detection tube; 3. In the use state, the inner sealing component 6-2-1 is pushed to the second channel, and the internal part of the connecting cavity 1-3 is connected. The outer sealing component 6-2-2 is located on the side of the connection port between the connecting cavity 1-3 and the sample storage tube 5 away from the second channel to prevent the storage liquid from overflowing. The storage liquid flows in the first channel through the gap between the push rod and the sealing component and flows into the third channel through the second channel, and finally reaches the detection tube 2 and contacts with the reagent strip 3-2.

[0043] Embodiment 4, by Figures 6 to 9It is given that, based on the first embodiment, a fixing structure 3 is movably installed in the detection tube 2, and the fixing structure 3 includes a main body 3-1 and a cover body. A reagent strip 3-2 is installed on one side of the main body 3-1, and a groove for placing the reagent strip 3-2 and a tooth 3-1-1 for fixing the reagent strip and preventing the reagent strip from falling off are provided on the side of the main body 3-1. An anti-overflow tray 3-1-3 is provided at the bottom of the main body 3-1. The anti-overflow tray 3-1-3 is located on the back side of the main body 3-1 on which the reagent strip 3-2 is placed, and is in the shape of a semicircular plate. It prevents the storage liquid with the sample from entering the detection tube 2 and flowing into the side where the reagent strip is not placed, resulting in inaccurate results due to less contact between the reagent strip and the sample, and also avoids waste of storage liquid. If the flow rate is too fast and a large amount of liquid flows into the test tube, it will infect the non-test point part of the reagent strip 3-2 and cause the test strip to become invalid. The anti-overflow plate 3-1-3 set on the back will not block the connection between the test tube 2 and the connecting cavity 1-3. The air vent 3-1-2 is set on the cover body to balance the internal and external atmospheric pressures of the device, accelerate the flow of buffer liquid to the inner cavity 2-2 of the test tube, reduce the reaction time, and speed up the test results. In addition, the test strip 3-2 is installed in the test tube after production and delivery. If the test strip in the test tube is used to detect disease A at the time of delivery, it needs to be temporarily replaced to detect disease B later. The fixed structure 3 movably installed with the test tube 2 can be taken out and the test strip can be replaced accordingly. That is, standard production can be planned in advance, and temporary emergency supplements can be made due to temporary plan adjustments.

[0044] On the basis of the above embodiment, a guide structure is set between the fixed structure 3 and the detection tube, and the guide structure includes a guide strip 2-1 and a guide groove 3-3. The guide strip 2-1 is set on the inner wall of the detection tube 2, and the guide groove 3-3 is located on the cover body of the fixed structure and is adapted to the guide strip 2-1. The guide device plays a guiding role when the fixed structure is installed, and plays a limiting role after the fixed structure is installed to keep the reagent strip placed vertically.

[0045] Example 5: By Figures 6 and 7 It is given that, on the basis of Example 1, the detection device includes a pushing piece 7, and a fixed space for assembling the pushing piece 7 is provided at the bottom of the base 1. The pushing piece 7 is detachably connected to the base 1 through a limiting structure. The limiting structure includes a limiting boss 7-1 on the pushing piece 7, a limiting flange 7-2 and a fixing bar 1-1 and a flange fixing foot 1-2 at the fixed space. The fixing bar 1-1 is a raised structure in the fixed space, which mainly plays the role of clamping and pressing the pushing piece 7. The limiting boss 7-1, the limiting flange 7-2 and the flange fixing foot 1-2 are used in combination. The pushing piece 7 is rotated 90° clockwise to lock the limit, which can prevent the pushing piece 7 from falling off during transportation vibration. When using the pushing piece 7, rotate it 90° counterclockwise to take it down for use.

[0046] On the basis of the above embodiment, a positioning structure is provided between the pushing member 7 and the sealing structure 6. The positioning structure includes a groove provided on the sealing structure 6 and a convex head provided on the pushing member 7. The groove is located at one end portion of the push rod 6-1 for installing the outer sealing component. The convex head is inserted into the groove for stable connection. By applying force to the sealing structure 6 by the pushing member 7, the pushing member 7 can move the sealing structure 6 from a position close to the sample storage tube 5 to a direction close to the detection tube 2, thereby realizing communication between the detection tube 2 and the internal cavity of the sample storage tube 5.

[0047] The working principle of the present invention is as follows: the sample storage tube 5 is pre-filled with a buffer liquid, and a reagent strip 3-2 is installed at the fixed structure 3 in the detection tube 2. When in use, the subject is sampled using a sampling cotton swab. The cotton swab is inserted into the sample storage tube 5, and the cotton swab head is directly retained in the sample storage tube 5 through the break point on the cotton swab stick. The sample is sealed by the sealing cap 4. After a period of static reaction, the pusher 7 is removed from the base 1. The positioning structure between the pusher 7 and the sealing structure is engaged. The sealing structure 6 is pushed toward the detection tube until the inner sealing assembly reaches the end of the second channel, thereby connecting the connecting cavity 1-3 inside the base 1, the sample storage tube lumen 5-2, and the detection tube lumen 2-2. The buffer liquid flows from the sample storage tube lumen 5-2 through the connecting cavity 1-3 to the detection tube lumen 2-2. After the buffer liquid containing the test sample impregnates the reagent strip, the reagent strip produces corresponding changes. The user can observe the C line and T line displayed on the reagent strip through the viewing window on the detection tube body to determine the test result.

[0048] Although the preferred embodiments of the present invention have been described in detail above, it should be clearly understood that various modifications and variations are possible for those skilled in the art. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention are intended to be included within the scope of protection of the present invention.

Claims

1. A detection device, characterized in that: The detection device comprises a sample storage tube (5) and a detection tube (2) which are independently arranged. A base (1) is arranged at the bottom of the detection device. The internal cavity of the sample storage tube (5) is in an inverted cone shape. The sample storage tube (5) and the detection tube (2) are connected to each other through a connecting cavity (1-3). The connecting cavity (1-3) is arranged in the base (1). A sealing structure (6) is arranged in the connecting cavity (1-3). The sealing structure (6) is movably matched with the connecting cavity (1-3). The connecting cavity (1-3) comprises a first channel, a second channel and a third channel which are connected in sequence. The sealing structure (6) comprises a sealing component and a push rod (6-1). The sealing component comprises an inner sealing component (6-2-1) and an outer sealing component (6-2-2) which are respectively arranged at both ends of the push rod (6-1). The sealing structure (6) is movably arranged in the first channel. The inner sealing component is located at one end of the push rod (6-1) close to the second channel. The sealing structure (6) satisfies the following conditions: a gap exists between the push rod (6-1) and the sealing component for the buffer liquid to flow; in an initial state, the inner sealing component (6-2-1) and the outer sealing component (6-2-2) are respectively located on both sides of the connection port between the connecting cavity (1-3) and the sample storage tube (5); in a use state, the inner sealing component (6-2-1) is pushed to the second channel, the interior of the connecting cavity (1-3) is connected, and the outer sealing component (6-2-2) is located on the side of the connection port between the connecting cavity (1-3) and the sample storage tube (5) away from the second channel to prevent the storage liquid from overflowing. The storage liquid flows in the first channel through the gap between the push rod and the sealing component and flows into the third channel through the second channel, and finally reaches the detection tube (2) and contacts the reagent strip (3-2).

2. A detection device according to claim 1, characterized in that: The communicating cavity (1-3) is a stepped pipe structure.

3. A detection device according to claim 1, characterized in that: A fixed structure is provided in the detection tube (2), the fixed structure being movably connected to the detection tube (2), and the fixed structure comprising a main body (3-1).

4. A detection device according to claim 1, characterized in that: A fixed structure is provided in the detection tube (2), and a guide structure is provided between the fixed structure and the detection tube (2).

5. A detection device according to claim 3, characterized in that: A latching tooth (3-1-1) is provided on one side of the main body (3-1), and an anti-overflow plate (3-1-3) is provided on the main body (3-1) near the connection port between the communicating cavity (1-3) and the detection tube (2). The anti-overflow plate (3-1-3) is located on the side of the main body (3-1) where the latching tooth is not provided.

6. A detection device according to claim 1, characterized in that: The detection device comprises a push piece (7), the push piece (7) is detachably connected to the detection device via a connecting structure, the connecting structure comprises a limiting boss (7-1) and a limiting flange (7-2) arranged on the push piece (7), and a flange fixing foot (1-2) arranged on the detection device, the limiting boss (7-1), the limiting flange (7-2) and the flange fixing foot (1-2) are rotatably matched, and a fixing strip (1-1) is arranged in the flange fixing foot (1-2).

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