Method for amplifying and converting signals of a triple quadrupole mass spectrometer system

Abstract

The present invention provides a method for amplifying and converting signals of a triple quadrupole mass spectrometer system. The method analyzes corresponding detected peak signal sub-spectra extracted from analog detection signal spectra output by the triple quadrupole mass spectrometer system at different times to determine whether the analog detection signal currently output by the mass spectrometer system is normal. And when the analog detection signal output by the mass spectrometer system is abnormal, the power supply voltage of the mass spectrometer system is corrected, and then the analog voltage signals included in the corrected analog detection signal spectrum after correcting the power supply voltage are amplified and AD-converted to obtain corresponding analog voltage - digital voltage floating change values, so as to store the digital voltage signals in a differentiated manner. It uses a non-fixed reference voltage signal to amplify and AD-convert the analog voltage signals, thereby reducing the conversion drift deviation of the converted digital voltage signals and improving the accuracy and reliability of mass spectrometer detection.

Description

Technical Field

[0001] The present invention relates to the technical field of mass spectrometer signal processing, and particularly to a method for amplifying and converting signals of a triple quadrupole mass spectrometer system. Background Art

[0002] The triple quadrupole mass spectrometer has the characteristics of high sensitivity, fast analysis speed, and small sample consumption, and is widely used in the fields of medicine and biological analysis. After the sample is ionized by electrospray ionization, it enters multiple detection channels of the triple quadrupole mass spectrometer for mass spectrometry analysis, so that different components of the sample can be synchronously detected and analyzed, thereby realizing multi-channel analysis of the sample. The detection result output by the triple quadrupole mass spectrometer is an analog signal, so the analog signal needs to be further sent to an amplification circuit board and an AD conversion circuit board for amplification and analog-to-digital conversion to obtain the corresponding digital signal. In the actual AD conversion process, a corresponding standard power supply voltage needs to be set as the reference benchmark for converting the analog voltage signal into a digital voltage signal. However, the existing technologies all use a single fixed voltage value as the reference benchmark, which makes the digital voltage signal obtained by AD conversion have a large conversion drift deviation, reducing the accuracy and reliability of the mass spectrometer detection. Summary of the Invention

[0003] Aiming at the defects existing in the prior art, the present invention provides a method for amplifying and converting signals of a triple quadrupole mass spectrometer system, which analyzes and extracts corresponding detected peak signal sub-spectra from the analog detection signal spectra output by the triple quadrupole mass spectrometer system at different times, so as to judge whether the analog detection signal currently output by the mass spectrometer system is normal; and when the analog detection signal output by the mass spectrometer system is abnormal, correct the power supply voltage of the mass spectrometer system, and then perform amplification and AD conversion processing on the analog voltage signal included in the corrected analog detection signal spectrum after correcting the power supply voltage to obtain the corresponding analog voltage-digital voltage floating change value, so as to store the digital voltage signal in a differentiated manner. First, it verifies according to the detection output result of the mass spectrometer system for a preset standard sample to correct the power supply voltage of the mass spectrometer system, and then uses a non-fixed reference voltage signal to perform amplification and AD conversion processing on the analog voltage signal, thereby reducing the conversion drift deviation of the obtained digital voltage signal and improving the accuracy and reliability of the mass spectrometer detection.

[0004] The present invention provides a method for amplifying and converting signals of a triple quadrupole mass spectrometer system, which includes the following steps:

[0005] Step S1, obtain the analog detection signal spectra output by the triple quadrupole mass spectrometer system at different times, and extract the detected peak signal sub-spectra included in the analog detection signal spectra; compare the detected peak signal sub-spectra corresponding to different times to judge whether the analog detection signal currently output by the mass spectrometer system is in a normal state;

[0006] Step S2, according to the judgment result of whether the analog detection signal output by the mass spectrometer system is normal currently, correct the power supply voltage of the mass spectrometer system; then obtain the calibrated analog detection signal spectrum output by the mass spectrometer system after the power supply voltage correction;

[0007] Step S3, extract the corresponding analog voltage signal from the calibrated analog detection signal spectrum, and perform amplification and AD conversion processing on the analog voltage signal according to the reference voltage signal, so as to obtain the digital voltage signal and its corresponding analog voltage - digital voltage floating change value; then store the digital voltage signal differentially according to the analog voltage - digital voltage floating change value.

[0008] Further, in the step S1, obtaining the analog detection signal spectra output by the triple quadrupole mass spectrometer system at different times, and extracting the detection peak signal sub - spectra included in the analog detection signal spectra specifically includes:

[0009] Place a preset standard sample in the triple quadrupole mass spectrometer system, and obtain the first analog detection signal spectrum, the second analog detection signal spectrum, and the third analog detection signal spectrum corresponding to the mass spectrometry detection of the preset standard sample by the mass spectrometer system at the first time, the second time, and the third time in sequence; wherein, the time interval between the first time and the second time is equal to the time interval between the second time and the third time, and the time interval from the first time to the start time of the mass spectrometer system is greater than or equal to the calibrated warm - up time of the mass spectrometer system;

[0010] According to the mass - to - charge ratio of the sample ions included in the preset standard sample, extract the corresponding detection peak signal sub - spectra from the first analog detection signal spectrum, the second analog detection signal spectrum, and the third analog detection signal spectrum respectively.

[0011] Further, in the step S1, comparing the detection peak signal sub - spectra corresponding to different times to judge whether the analog detection signal output by the mass spectrometer system is normal currently specifically includes:

[0012] Extract the detection peak signal sub - spectra regarding the same peak frequency from the first analog detection signal spectrum, the second analog detection signal spectrum, and the third analog detection signal spectrum, and then determine the half - wave peak intensity of all detection peak signal sub - spectra;

[0013] Determine the first half - wave peak intensity difference between the half - wave peak intensity corresponding to the first time and the half - wave peak intensity corresponding to the second time, and the second half - wave peak intensity difference between the half - wave peak intensity corresponding to the second time and the half - wave peak intensity corresponding to the third time;

[0014] If both the first half-wave peak intensity difference and the second half-wave peak intensity difference are less than or equal to the threshold difference threshold, it is determined that the analog detection signal currently output by the mass spectrometer system is in a normal state; otherwise, it is determined that the analog detection signal currently output by the mass spectrometer system is in an abnormal state.

[0015] Further, in step S2, according to the judgment result of whether the analog detection signal currently output by the mass spectrometer system is normal, the power supply voltage of the mass spectrometer system is corrected as follows:

[0016] When it is determined that the analog detection signal currently output by the mass spectrometer system is in a normal state, the current power supply voltage of the mass spectrometer system is kept unchanged;

[0017] When it is determined that the analog detection signal currently output by the mass spectrometer system is in an abnormal state, the power supply voltage from the power supply is first subjected to high-frequency filtering, and then the power supply voltage is supplied to the mass spectrometer system, thereby realizing the correction of the power supply voltage of the mass spectrometer system.

[0018] Further, in step S2, obtaining the calibrated analog detection signal spectrum output by the mass spectrometer system after power supply voltage correction specifically includes:

[0019] After the power supply voltage of the mass spectrometer system is corrected, the sample to be detected is placed in the mass spectrometer system, and the calibrated analog detection signal spectrum output within a complete detection cycle is obtained; wherein, the complete detection cycle refers to the time required for the mass spectrometer system to perform a complete scan on the sample to be detected.

[0020] Further, in step S3, the corresponding analog voltage signal is extracted from the calibrated analog detection signal spectrum, and the analog voltage signal is amplified and AD-converted according to the reference voltage signal, so as to obtain the digital voltage signal and its corresponding analog voltage-digital voltage floating change value, specifically including:

[0021] Step S301, extracting the analog voltage signal component included in the signal from the calibrated analog detection signal spectrum, and performing Kalman filtering on the analog voltage signal component;

[0022] Step S302, obtaining the corresponding reference voltage signal according to two preset reference digital signals; and then amplifying and AD-converting the analog voltage signal according to the reference voltage signal, so as to obtain the digital voltage signal corresponding to the analog voltage signal;

[0023] Step S303, obtaining the analog voltage-digital voltage floating change range according to the reference voltage signal and the digital voltage signal.

[0024] Further, in the step S302, according to two preset reference digital signals, corresponding reference voltage signals are obtained; then, according to the reference voltage signals, the analog voltage signals are amplified and AD-converted to obtain digital voltage signals corresponding to the analog voltage signals, which specifically includes:

[0025] Using the following formula (1), self-judgment synthesis processing is performed on two preset reference digital signals to obtain corresponding reference voltage signals,

[0026]

[0027] In the above formula (1), d(t) represents obtaining corresponding reference voltage signals through self-judgment synthesis processing of two preset reference digital signals; t represents the current moment; D1(t) represents the first preset reference digital signal corresponding to the current moment t; D2(t) represents the second preset reference digital signal corresponding to the current moment t; | | represents the absolute value operation; d max represents the digital signal value obtained after the input voltage signal corresponding to the mass spectrometer system under the rated working voltage input is amplified and AD-converted; min[] represents the minimum value operation within the brackets;

[0028] Then, using the following formula (2), according to the reference voltage signals, the analog voltage signals are amplified and AD-converted to obtain digital voltage signals corresponding to the analog voltage signals,

[0029]

[0030] In the above formula (2), u(t) represents the digital voltage signal value corresponding to the analog voltage signal at the current moment t; G(t) represents the initial digital voltage signal obtained by amplifying and AD-converting the analog voltage signal at the current moment t; U p represents the standard power supply voltage value corresponding to the mass spectrometer system;

[0031] And,

[0032] In the step S303, according to the reference voltage signals and the digital voltage signals, obtaining the analog voltage - digital voltage floating change interval range specifically includes:

[0033] Using the following formula (3), according to the reference voltage signals and the digital voltage signals, the analog voltage - digital voltage floating change interval range is obtained,

[0034]

[0035] In the above formula (3), Δu(t) represents the floating parameter of the voltage accurate value corresponding to the analog voltage signal output by the mass spectrometer system at the current moment t;

[0036] If u(t) - Δu(t) > 0 and u(t) + Δu(t) < U p , then the floating change interval range of the analog voltage - digital voltage is [u(t) - Δu(t), u(t) + Δu(t)];

[0037] If u(t) - Δu(t) ≤ 0 and u(t) + Δu(t) < U p , then the floating change interval range of the analog voltage - digital voltage is [0, u(t) + Δu(t)];

[0038] If u(t) - Δu(t) > 0 and u(t) + Δu(t) ≥ U p , then the floating change interval range of the analog voltage - digital voltage is [u(t) - Δu(t), U p ;

[0039] If u(t) - Δu(t) ≤ 0 and u(t) + Δu(t) ≥ U p , then the floating change interval range of the analog voltage - digital voltage is [0, U p ;

[0040] Further, in the step S3, differentiating and storing the digital voltage signal according to the floating change value of the analog voltage - digital voltage specifically includes:

[0041] Storing the corresponding different digital voltage signals into different detection signal processing channels according to the floating change interval range of the analog voltage - digital voltage; among them, different detection signal processing channels have different signal processing error tolerances, and when the floating change interval range of the analog voltage - digital voltage is larger, the signal processing error tolerance of the corresponding detection signal processing channel is also larger.

[0042] Compared with the prior art, the method for amplifying and converting the signals of the triple quadrupole mass spectrometer system analyzes the corresponding detected peak signal sub-spectrum extracted from the analog detection signal spectra output by the triple quadrupole mass spectrometer system at different times to determine whether the analog detection signal currently output by the mass spectrometer system is normal; and when the analog detection signal output by the mass spectrometer system is abnormal, corrects the power supply voltage of the mass spectrometer system, and then amplifies and performs AD conversion processing on the analog voltage signals included in the corrected analog detection signal spectrum after correcting the power supply voltage to obtain the corresponding analog voltage - digital voltage floating change value, and stores the digital voltage signals differentially. First, it verifies according to the detection output result of the mass spectrometer system for a preset standard sample to correct the power supply voltage of the mass spectrometer system, and then uses a non-fixed reference voltage signal to amplify and perform AD conversion processing on the analog voltage signals, thereby reducing the conversion drift deviation of the converted digital voltage signals and improving the accuracy and reliability of mass spectrometry detection.

[0043] Other features and advantages of the present invention will be described in the following specification, and, in part, will become apparent from the specification or be understood by practicing the present invention. The objectives and other advantages of the present invention can be achieved and obtained by the structures specifically pointed out in the written specification, claims, and drawings.

[0044] The technical solutions of the present invention will be further described in detail below through the accompanying drawings and embodiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0045] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the accompanying drawings required for describing the embodiments or the prior art. Obviously, the accompanying drawings in the following description are only some embodiments of the present invention, and those of ordinary skill in the art can also obtain other drawings without creative efforts based on these drawings.

[0046] Figure 1 It is a schematic flowchart of the method for amplifying and converting the signals of the triple quadrupole mass spectrometer system provided by the present invention. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0047] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, rather than all embodiments. All other embodiments obtained by those of ordinary skill in the art without creative efforts based on the embodiments of the present invention belong to the scope of protection of the present invention.

[0048] Refer to Figure 1, which is a schematic flowchart of the method for amplifying and converting signals of a triple quadrupole mass spectrometer system provided by an embodiment of the present invention. The method for amplifying and converting signals of the triple quadrupole mass spectrometer system includes the following steps:

[0049] Step S1, obtain the analog detection signal spectra output by the triple quadrupole mass spectrometer system at different times, and extract the detection peak signal sub-spectra included in the analog detection signal spectra; compare the detection peak signal sub-spectra corresponding to different times to determine whether the analog detection signal currently output by the mass spectrometer system is normal.

[0050] Step S2, correct the power supply voltage of the mass spectrometer system according to the judgment result of whether the analog detection signal currently output by the mass spectrometer system is normal; then obtain the calibrated analog detection signal spectrum output by the mass spectrometer system after the power supply voltage correction.

[0051] Step S3, extract the corresponding analog voltage signal from the calibrated analog detection signal spectrum, and perform amplification and AD conversion processing on the analog voltage signal according to the reference voltage signal, so as to obtain the digital voltage signal and its corresponding analog voltage-digital voltage floating change value; then store the digital voltage signal differentially according to the analog voltage-digital voltage floating change value.

[0052] The beneficial effects of the above technical solution are as follows: The method for amplifying and converting signals of the triple quadrupole mass spectrometer system analyzes and extracts the corresponding detection peak signal sub-spectra from the analog detection signal spectra output by the triple quadrupole mass spectrometer system at different times to determine whether the analog detection signal currently output by the mass spectrometer system is normal; and when the analog detection signal output by the mass spectrometer system is abnormal, correct the power supply voltage of the mass spectrometer system, and then perform amplification and AD conversion processing on the analog voltage signal included in the calibrated analog detection signal spectrum after correcting the power supply voltage to obtain the corresponding analog voltage-digital voltage floating change value, and store the digital voltage signal differentially based on this. It first verifies according to the detection output result of the mass spectrometer system for the preset standard sample to correct the power supply voltage of the mass spectrometer system, and then uses the non-fixed reference voltage signal to perform amplification and AD conversion processing on the analog voltage signal, thereby reducing the conversion drift deviation of the converted digital voltage signal and improving the accuracy and reliability of mass spectrometer detection.

[0053] Preferably, in this step S1, obtaining the analog detection signal spectra output by the triple quadrupole mass spectrometer system at different times and extracting the detection peak signal sub-spectra included in the analog detection signal spectra specifically includes:

[0054] Place a preset standard sample in a triple quadrupole mass spectrometer system, and obtain the first simulated detection signal spectrum, the second simulated detection signal spectrum, and the third simulated detection signal spectrum respectively output after the mass spectrometer system performs mass spectrometry detection on the preset standard sample at the first moment, the second moment, and the third moment; wherein, the time interval between the first moment and the second moment is equal to the time interval between the second moment and the third moment, and the time interval from the first moment to the start time of the mass spectrometer system is greater than or equal to the calibration warm-up time of the mass spectrometer system;

[0055] According to the mass-to-charge ratio of the sample ions contained in the preset standard sample, extract the corresponding detected peak signal sub-spectra from the first simulated detection signal spectrum, the second simulated detection signal spectrum, and the third simulated detection signal spectrum respectively.

[0056] The beneficial effects of the above technical solution are as follows: The triple quadrupole mass spectrometer system needs to perform corresponding calibration and correction before performing formal mass spectrometry detection on the sample to be detected, so as to ensure that the mass spectrometer system can perform mass spectrometry detection on the sample to be detected in a normal working state. Specifically, place a preset standard sample in the mass spectrometer system, and perform mass spectrometry detection on the preset standard sample at the first moment, the second moment, and the third moment at intervals in turn. The preset standard sample includes several known material components, and peak signals will appear in the corresponding frequency range of the simulated detection signal spectrum obtained after mass spectrometry detection. If there is a detection deviation in the mass spectrometer system, the peak signals contained in the simulated detection signals output at different times will have an offset. By extracting the existing peak signals and comparing them, it is possible to accurately judge whether the simulated detection signal output by the mass spectrometer system is normal.

[0057] Preferably, in this step S1, comparing the detected peak signal sub-spectra corresponding to different moments to judge whether the simulated detection signal currently output by the mass spectrometer system is normal specifically includes:

[0058] Extract the detected peak signal sub-spectra regarding the same peak frequency from the first simulated detection signal spectrum, the second simulated detection signal spectrum, and the third simulated detection signal spectrum, and then determine the half-peak intensity of all detected peak signal sub-spectra;

[0059] Determine the first half-peak intensity difference between the half-peak intensity corresponding to the first moment and the half-peak intensity corresponding to the second moment, and the second half-peak intensity difference between the half-peak intensity corresponding to the second moment and the half-peak intensity corresponding to the third moment;

[0060] If both the first half-peak intensity difference and the second half-peak intensity difference are less than or equal to the threshold difference threshold, it is determined that the simulated detection signal currently output by the mass spectrometer system is in a normal state; otherwise, it is determined that the simulated detection signal currently output by the mass spectrometer system is in an abnormal state.

[0061] The beneficial effects of the above technical solution are as follows: If there is a detection deviation in the mass spectrometer system, there will be a large deviation in the intensity of the peak signals contained in the analog detection signals detected and output at different times. The detection peak signal sub-spectra regarding the same peak frequency are extracted from the first analog detection signal spectrum, the second analog detection signal spectrum, and the third analog detection signal spectrum, and the corresponding half-peak value intensity is determined, which can quickly and quantitatively judge whether the analog detection signal currently output by the mass spectrometer system is in a normal state or an abnormal state, thereby providing a reliable basis for subsequent power supply voltage correction of the mass spectrometer system.

[0062] Preferably, in this step S2, according to the judgment result of whether the analog detection signal currently output by the mass spectrometer system is normal, the power supply voltage correction of the mass spectrometer system specifically includes:

[0063] When it is determined that the analog detection signal currently output by the mass spectrometer system is in a normal state, the current power supply voltage to the mass spectrometer system is kept unchanged;

[0064] When it is determined that the analog detection signal currently output by the mass spectrometer system is in an abnormal state, first perform high-frequency filtering on the power supply voltage from the power supply, and then deliver the power supply voltage to the mass spectrometer system, thereby realizing the power supply voltage correction of the mass spectrometer system.

[0065] The beneficial effects of the above technical solution are as follows: When it is determined that the analog detection signal currently output by the mass spectrometer system is in a normal state, this indicates that the mass spectrometer system can perform mass spectrometry detection normally and there is no need to additionally adjust the power supply voltage of the mass spectrometer system. When it is determined that the analog detection signal currently output by the mass spectrometer system is in an abnormal state, first perform high-frequency filtering on the power supply voltage from the power supply, and then deliver the power supply voltage to the mass spectrometer system, which can avoid the interference of the high-frequency voltage components from the power supply to the normal operation of the mass spectrometer system.

[0066] Preferably, in this step S2, obtaining the calibrated analog detection signal spectrum output by the mass spectrometer system after power supply voltage correction specifically includes:

[0067] After the power supply voltage of the mass spectrometer system is corrected, place the sample to be detected in the mass spectrometer system, and obtain the calibrated analog detection signal spectrum output within a complete detection cycle; wherein, this complete detection cycle refers to the time required for the mass spectrometer system to perform a complete scan on the sample to be detected.

[0068] The beneficial effects of the above technical solution are as follows: After the power supply voltage of the mass spectrometer system is corrected, the sample to be detected is placed in the mass spectrometer system, and the calibrated analog detection signal spectrum output within a complete detection cycle is obtained. In this way, the sample to be detected can be comprehensively and refinedly detected in the entire frequency spectrum band, thereby avoiding the situation of missing detection of the sample to be detected.

[0069] Preferably, in this step S3, the corresponding analog voltage signal is extracted from the calibrated analog detection signal spectrum, and the analog voltage signal is amplified and AD-converted according to the reference voltage signal, so as to obtain the digital voltage signal and its corresponding analog voltage-digital voltage floating change value, which specifically includes:

[0070] Step S301, extract the analog voltage signal component included in the signal from the calibrated analog detection signal spectrum, and perform Kalman filtering on the analog voltage signal component;

[0071] Step S302, obtain the corresponding reference voltage signal according to two preset reference digital signals; then, according to the reference voltage signal, amplify and AD-convert the analog voltage signal, so as to obtain the digital voltage signal corresponding to the analog voltage signal;

[0072] Step S303, obtain the analog voltage-digital voltage floating change range according to the reference voltage signal and the digital voltage signal.

[0073] The beneficial effects of the above technical solution are as follows: The reference voltage signal is generated according to two preset reference digital signals, which is different from the prior art that uses a fixed voltage value as the reference voltage for AD conversion, thereby improving the correction accuracy of the reference voltage signal for the analog voltage signal during the AD conversion process. In addition, the analog voltage-digital voltage floating change range is obtained according to the reference voltage signal and the digital voltage signal, which is convenient for subsequent correction of the digital voltage signal according to this range, and improves the practicality of the detection results of the mass spectrometer system.

[0074] Preferably, in this step S302, obtain the corresponding reference voltage signal according to two preset reference digital signals; then, according to the reference voltage signal, amplify and AD-convert the analog voltage signal, so as to obtain the digital voltage signal corresponding to the analog voltage signal, which specifically includes:

[0075] Use the following formula (1) to perform self-judgment synthesis processing on two preset reference digital signals to obtain the corresponding reference voltage signal,

[0076]

[0077] In the above formula (1), d(t) represents the corresponding reference voltage signal obtained by self - judgment synthesis processing of two preset reference digital signals; t represents the current moment; D1(t) represents the first preset reference digital signal corresponding to the current moment t; D2(t) represents the second preset reference digital signal corresponding to the current moment t; | | represents the absolute - value operation; d max represents the digital signal value obtained after the input voltage signal corresponding to the mass spectrometer system under the rated working voltage input is amplified and AD - converted; min[] represents the minimum - value operation within the brackets;

[0078] Then, using the following formula (2), based on this reference voltage signal, the analog voltage signal is amplified and AD - converted to obtain a digital voltage signal corresponding to the analog voltage signal.

[0079]

[0080] In the above formula (2), u(t) represents the digital voltage signal value corresponding to the current moment t and the analog voltage signal; G(t) represents the initial digital voltage signal obtained by amplifying and AD - converting the analog voltage signal at the current moment t; U p represents the standard power - supply voltage value corresponding to the mass spectrometer system;

[0081] And,

[0082] In this step S303, obtaining the floating change range of the analog voltage - digital voltage based on the reference voltage signal and the digital voltage signal specifically includes:

[0083] Using the following formula (3), based on the reference voltage signal and the digital voltage signal, the floating change range of the analog voltage - digital voltage is obtained.

[0084]

[0085] In the above formula (3), Δu(t) represents the floating parameter of the voltage accuracy value corresponding to the analog voltage signal output by the mass spectrometer system at the current moment t;

[0086] If u(t)-Δu(t)>0 and u(t)+Δu(t)<U p , then the floating change range of the analog voltage - digital voltage is [u(t)-Δu(t),u(t)+Δu(t)];

[0087] If u(t)-Δu(t)≤0 and u(t)+Δu(t)<U p , then the floating change range of the analog voltage - digital voltage is [0,u(t)+Δu(t)];

[0088] If u(t) - Δu(t) > 0 and u(t) + Δu(t) ≥ U p , then the floating change range of the analog voltage - digital voltage is [u(t) - Δu(t), U p .

[0089] If u(t) - Δu(t) ≤ 0 and u(t) + Δu(t) ≥ U p , then the floating change range of the analog voltage - digital voltage is [0, U p .

[0090] The beneficial effects of the above technical solution are as follows: Using the above formula (1), a reference voltage signal is self - judged and synthesized based on two preset reference digital signals, and then the two reference digital signals are corrected as a whole for the system, so as to ensure the accuracy of subsequent calculations; then, using the above formula (2), the actual digital voltage signal of the analog signal of the triple quadrupole mass spectrometer system is calculated according to the synthesized reference voltage signal and the analog voltage signal of the triple quadrupole mass spectrometer system, so that the real - time analog signal voltage value can be calculated quickly, and the accuracy of the result is ensured by referring to the reference voltage signal; finally, using the above formula (3), the floating change range of the analog voltage - digital voltage of the triple quadrupole mass spectrometer system is obtained according to the synthesized reference voltage signal and the two preset reference digital signals. First, it can be known whether the voltage supplying power to the triple quadrupole mass spectrometer system is stable through the floating change range. Second, the calculated digital voltage signal can be further refined and intervalized through the floating change range to ensure that the overall accuracy interval of the system meets the requirements.

[0091] Preferably, in step S3, differentiating and storing the digital voltage signal according to the floating change value of the analog voltage - digital voltage specifically includes:

[0092] Storing the corresponding different digital voltage signals into different detection signal processing channels according to the floating change range of the analog voltage - digital voltage; among them, different detection signal processing channels have different signal - processing error tolerances. When the floating change range of the analog voltage - digital voltage is larger, the signal - processing error tolerance of the corresponding detection signal processing channel is also larger.

[0093] The beneficial effects of the above technical solution are as follows: According to the floating change range of the analog voltage - digital voltage, different digital voltage signals are stored in different detection signal processing channels. In this way, the digital voltage signals can be processed in parallel through different detection signal processing channels, and the digital voltage signals with a larger floating change range of analog voltage - digital voltage are stored in the detection signal processing channels with a larger error tolerance, which can effectively reduce the workload of processing digital voltage signals and improve the processing efficiency of digital voltage signals.

[0094] As can be seen from the content of the above embodiments, the method for analyzing the amplification and conversion of the signals of the triple quadrupole mass spectrometer system extracts the corresponding detected peak signal sub - spectra from the analog detection signal spectra output by the triple quadrupole mass spectrometer system at different times to determine whether the analog detection signal currently output by the mass spectrometer system is normal; and when the analog detection signal output by the mass spectrometer system is abnormal, the power supply voltage of the mass spectrometer system is corrected, and then the analog voltage signals included in the corrected analog detection signal spectra after correcting the power supply voltage are amplified and AD - converted to obtain the corresponding floating change values of analog voltage - digital voltage, so as to store the digital voltage signals in a differentiated manner. First, it verifies according to the detection output result of the mass spectrometer system for the preset standard sample to correct the power supply voltage of the mass spectrometer system, and then uses a non - fixed reference voltage signal to amplify and AD - convert the analog voltage signals, thereby reducing the conversion drift deviation of the converted digital voltage signals and improving the accuracy and reliability of mass spectrometer detection.

[0095] Obviously, those skilled in the art can make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalent technologies, the present invention also intends to include these changes and modifications.

Claims

1. A method for amplifying and converting signals of a triple quadrupole mass spectrometer system, characterized in that It includes the following steps: Step S1: Obtain the analog detection signal spectra output by the triple quadrupole mass spectrometer system at different times, and extract the detection peak signal sub-spectra included in the analog detection signal spectra; compare the detection peak signal sub-spectra corresponding to different times to determine whether the analog detection signal currently output by the mass spectrometer system is normal; Step S2: According to the judgment result of whether the analog detection signal currently output by the mass spectrometer system is normal, correct the power supply voltage of the mass spectrometer system; then obtain the calibrated analog detection signal spectra output by the mass spectrometer system after the power supply voltage correction; Step S3: Extract the corresponding analog voltage signals from the calibrated analog detection signal spectra, and perform amplification and AD conversion processing on the analog voltage signals according to the reference voltage signal, so as to obtain digital voltage signals and their corresponding analog voltage-digital voltage floating change values; then, according to the analog voltage-digital voltage floating change values, perform differential storage on the digital voltage signals; Among them, the amplification and AD conversion processing of the analog voltage signal according to the reference voltage signal includes: obtaining the corresponding reference voltage signal according to two preset reference digital signals; then performing amplification and AD conversion processing on the analog voltage signal according to the reference voltage signal.

2. The method for amplifying and converting the signal of the triple quadrupole mass spectrometer system according to claim 1, characterized in that: In the step S1, obtaining the analog detection signal spectra output by the triple quadrupole mass spectrometer system at different times, and extracting the detection peak signal sub-spectra included in the analog detection signal spectra specifically includes: Placing a preset standard sample in the triple quadrupole mass spectrometer system, and obtaining the first analog detection signal spectrum, the second analog detection signal spectrum, and the third analog detection signal spectrum corresponding to the mass spectrometer system's mass spectrometry detection of the preset standard sample at the first time, the second time, and the third time in sequence; wherein, the time interval between the first time and the second time is equal to the time interval between the second time and the third time, and the time interval from the first time to the start time of the mass spectrometer system is greater than or equal to the calibrated warm-up time of the mass spectrometer system; According to the mass-to-charge ratio of the sample ions included in the preset standard sample, extract the corresponding detection peak signal sub-spectra from the first analog detection signal spectrum, the second analog detection signal spectrum, and the third analog detection signal spectrum respectively.

3. The method for amplifying and converting the signal of the triple quadrupole mass spectrometer system according to claim 2, characterized in that: In the step S1, comparing the detection peak signal sub-spectra corresponding to different times to determine whether the analog detection signal currently output by the mass spectrometer system is normal specifically includes: Extracting the detection peak signal sub-spectra of the same peak frequency from the first analog detection signal spectrum, the second analog detection signal spectrum, and the third analog detection signal spectrum, and then determining the half-wave peak intensity of all the detection peak signal sub-spectra; Determine the first half-wave peak intensity difference between the half-wave peak intensity corresponding to the first moment and the half-wave peak intensity corresponding to the second moment, and the second half-wave peak intensity difference between the half-wave peak intensity corresponding to the second moment and the half-wave peak intensity at the third moment; If both the first half-wave peak intensity difference and the second half-wave peak intensity difference are less than or equal to the threshold difference threshold, it is determined that the analog detection signal currently output by the mass spectrometer system is in a normal state; otherwise, it is determined that the analog detection signal currently output by the mass spectrometer system is in an abnormal state.

4. The method for amplifying and converting the signal of a triple quadrupole mass spectrometer system according to claim 3, wherein: In the step S2, according to the judgment result of whether the analog detection signal currently output by the mass spectrometer system is normal, the power supply voltage of the mass spectrometer system is corrected as follows: When it is determined that the analog detection signal currently output by the mass spectrometer system is in a normal state, the current power supply voltage of the mass spectrometer system is kept unchanged; When it is determined that the analog detection signal currently output by the mass spectrometer system is in an abnormal state, the power supply voltage from the power supply is first subjected to high-frequency filtering, and then the power supply voltage is sent to the mass spectrometer system, so as to realize the correction of the power supply voltage of the mass spectrometer system.

5. The method for amplifying and converting the signal of a triple quadrupole mass spectrometer system according to claim 4, wherein: In the step S2, obtaining the calibrated analog detection signal spectrum output by the mass spectrometer system after power supply voltage correction specifically includes: After the power supply voltage of the mass spectrometer system is corrected, place the sample to be detected in the mass spectrometer system, and obtain the calibrated analog detection signal spectrum output within a complete detection cycle; wherein, the complete detection cycle refers to the time required for the mass spectrometer system to perform a complete scan on the sample to be detected.

6. The method for amplifying and converting the signal of a triple quadrupole mass spectrometer system according to claim 5, wherein: In the step S3, extract the corresponding analog voltage signal from the calibrated analog detection signal spectrum, and perform amplification and AD conversion processing on the analog voltage signal according to the reference voltage signal, so as to obtain the digital voltage signal and its corresponding analog voltage-digital voltage floating change value, specifically including: Step S301, extract the analog voltage signal component included in the signal from the calibrated analog detection signal spectrum, and perform Kalman filtering on the analog voltage signal component; Step S302, obtain the corresponding reference voltage signal according to two preset reference digital signals; then perform amplification and AD conversion processing on the analog voltage signal according to the reference voltage signal, so as to obtain the digital voltage signal corresponding to the analog voltage signal; Step S303, obtain the analog voltage-digital voltage floating change range according to the reference voltage signal and the digital voltage signal.

7. The method for amplifying and converting the signal of a triple quadrupole mass spectrometer system according to claim 6, wherein: In the step S302, according to two preset reference digital signals, a corresponding reference voltage signal is obtained; then, according to the reference voltage signal, the analog voltage signal is amplified and subjected to AD conversion processing, so as to obtain a digital voltage signal corresponding to the analog voltage signal, which specifically includes: Using the following formula (1), self-judgment synthesis processing is performed on two preset reference digital signals to obtain a corresponding reference voltage signal, In the above formula (1), d(t) represents the corresponding reference voltage signal obtained by self-judgment synthesis processing of two preset reference digital signals; t represents the current time; D1(t) represents the first preset reference digital signal corresponding to the current time t; D2(t) represents the second preset reference digital signal corresponding to the current time t; || represents the absolute value operation; d max represents the digital signal value obtained after the input voltage signal corresponding to the mass spectrometer system under the rated working voltage input is amplified and AD-converted; min[] represents the minimum value operation within the brackets; Then, using the following formula (2), according to the reference voltage signal, the analog voltage signal is amplified and subjected to AD conversion processing, so as to obtain a digital voltage signal corresponding to the analog voltage signal, In the above formula (2), u(t) represents the digital voltage signal value corresponding to the analog voltage signal at the current moment t; G(t) represents the initial digital voltage signal obtained by amplifying and performing AD conversion processing on the analog voltage signal at the current moment t; U p represents the standard power supply voltage value corresponding to the mass spectrometer system; And, In the step S303, according to the reference voltage signal and the digital voltage signal, obtaining the analog voltage-digital voltage floating change interval range specifically includes: Using the following formula (3), according to the reference voltage signal and the digital voltage signal, the analog voltage-digital voltage floating change interval range is obtained, In the above formula (3), Δu(t) represents the floating parameter of the voltage accurate value corresponding to the analog voltage signal output by the mass spectrometer system at the current moment t; If u(t) - Δu(t) > 0 and u(t) + Δu(t) < U p , then the floating change range of the analog voltage - digital voltage is [u(t) - Δu(t), u(t) + Δu(t)]; If u(t) - Δu(t) ≤ 0 and u(t) + Δu(t) < U p , then the floating change range of the analog voltage - digital voltage is [0, u(t) + Δu(t)]; If u(t) - Δu(t) > 0 and u(t) + Δu(t) ≥ U p , then the floating change range of the analog voltage - digital voltage is [u(t) - Δu(t), U p ; If u(t) - Δu(t) ≤ 0 and u(t) + Δu(t) ≥ U p , then the floating change range of the analog voltage - digital voltage is [0, U p .

8. The method for amplifying and converting signals of a triple quadrupole mass spectrometer system according to claim 7, wherein: In the step S3, according to the analog voltage-digital voltage floating change value, differentiating and storing the digital voltage signal specifically includes: According to the analog voltage-digital voltage floating change interval range, different digital voltage signals are stored in different detection signal processing channels; wherein, different detection signal processing channels have different signal processing error tolerances, and when the analog voltage-digital voltage floating change interval range is larger, the signal processing error tolerance of the corresponding detection signal processing channel is also larger.

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