Hybrid damper and liquid chromatograph

Abstract

The application provides a mixing and uniform damping device and a liquid chromatograph, and relates to the technical field of liquid chromatographic analysis and detection equipment, and comprises a damping shell and a damping elastic body; the damping shell is provided with a sealed cavity, a first groove structure is arranged on the end surface of the damping elastic body corresponding to the damping shell, a second groove structure is arranged on the inner wall circumferential side wall of the damping elastic body corresponding to the damping shell, and the first groove structure and the second groove structure are communicated; the flow of the first groove structure and the second groove structure can mix and uniform the reagent of high-pressure liquid, the pulsation of the mobile phase pressure in the high-pressure pump liquid path system is inhibited by using the deformation storage of the damping elastic body, the mixing and uniform of the reagent of high-pressure liquid can be realized, the requirement of analysis precision is met, and the technical problems that the damping device cannot meet the mixing and uniform requirement in the prior art, a separate mixing device needs to be additionally arranged to prolong the gradient response time and affect the analysis precision are solved.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of liquid chromatography analysis detection equipment, in particular to a mixing damper and a liquid chromatograph. BACKGROUND

[0002] Common liquid chromatographs use micro high-pressure pumps as driving power for samples and reagents. Since most of them adopt plunger pump structure, the output pressure and flow rate are in sinusoidal wave form, and the highest pressure occurs in each cycle, while the lowest pressure is zero, which is unacceptable for precision analytical instruments. Therefore, a pulsation damper, also known as a pressure buffer, must be used to absorb pressure and store high-pressure liquid. When the pressure is too low, the high-pressure liquid is released to keep the pressure within a small fluctuation range.

[0003] In the prior art, liquid chromatographs use compressed fluid dampers, resonant cavity dampers, spring dampers, etc. The dampers used now have a large cavity inside the stainless steel shell, and it takes a long time to clean and replace the mobile phase. Due to the development of analytical technology, it usually takes 5 minutes to measure one sample, and now it takes about 50 seconds to measure one sample. During this period, more than three reagents need to be replaced. Many dampers have bypasses on the high-pressure pipeline, which is equivalent to the capacitance of a direct-current filter circuit connected in parallel to the reagent pipeline. Moreover, the large cavity results in more residue when replacing the reagent, and the gradual fusion between reagents takes a long time to analyze, which causes the analysis result to lag and the waveform boundary of several substances to be unclear, seriously affecting the analysis accuracy. Therefore, it is generally desirable to have a small dead volume inside the damper. Therefore, with the development of liquid chromatography analysis technology, different PH values or different percentages of reagents are used to mix two reagents in different proportions to obtain new PH values or new ratios. The method is to use a high-pressure pump to deliver each reagent, adjust the speed ratio of the two pumps, and mix the reagents output by the two pumps uniformly to obtain multiple reagents with different PH values or ratios. In order to mix the reagents uniformly, a liquid mixer needs to be connected in series after the high-pressure pump.

[0004] However, in the prior art, the damper and the mixer belong to two components, i.e. the damper in the prior art does not have a mixing effect. When mixing two reagents in different proportions to obtain new PH values or new ratios, a liquid mixer needs to be connected in series after the high-pressure pump, thereby increasing the liquid volume, i.e. the delay volume, and also prolonging the gradient response time. SUMMARY

[0005] The application aims to provide a mixing and damping device and a liquid chromatograph to alleviate the technical problem that the damping device cannot meet the mixing and damping needs in the prior art, and the separate mixing device needs to be added to prolong the gradient response time and affect the analysis accuracy.

[0006] The application provides a mixing and damping device, which comprises a damping shell and a damping elastic body.

[0007] The damping shell is provided with a sealed cavity, the damping elastic body is accommodated in the sealed cavity, and the side wall of the damping elastic body is attached to the inner wall of the damping shell.

[0008] The damping shell is provided with a liquid inlet and a liquid outlet at two ends respectively, the damping elastic body is provided with a first groove structure corresponding to the end surface of the damping shell, the first groove structure is in communication with the liquid inlet and the liquid outlet respectively, the damping elastic body is provided with a second groove structure corresponding to the circumferential side wall of the inner wall of the damping shell, and the first groove structure and the second groove structure are in communication.

[0009] In the preferred embodiment of the application, the damping elastic body is in a cylindrical structure, the first groove structure is arranged on the end surface of the damping elastic body of the cylindrical structure respectively, and the second groove structure is arranged along the circumferential side wall of the damping elastic body of the cylindrical structure.

[0010] In the preferred embodiment of the application, the first groove structure is arranged along the end surface of the damping elastic body in a plurality of intersecting spiral lines;

[0011] The second groove structure is arranged along the circumferential surface of the damping elastic body in a plurality of spiral lines with opposite directions, and the second groove structure is arranged in communication with the first groove structure at two ends of the damping elastic body.

[0012] In the preferred embodiment of the application, the first groove structure comprises two groups of involute circular grooves with opposite directions, each group of the involute circular grooves comprises 2-8 involute circles, the involute spiral line of each involute circle is 0.5-2 circumferential lines, and the number of the involute spiral lines with opposite directions in each group of the involute circular grooves is 2-6.

[0013] In the preferred embodiment of the application, the first groove structure comprises a first straight groove, a second straight groove, a first circular groove, a second circular groove and an oblique groove.

[0014] The first circular groove and the second circular groove are concentrically arranged with the end of the damping elastomer, the first linear groove and the second linear groove are provided in plurality, the plurality of first linear grooves are equidistantly arranged in the area surrounded by the first circular groove, the plurality of second linear grooves are equidistantly arranged in the area surrounded by the first circular groove, and each of the first linear groove and the second linear groove is vertically arranged, so that the first linear groove and the second linear groove form a plurality of regular quadrilaterals with the center of the first circular groove, wherein the regular quadrilateral close to the center is a first regular quadrilateral, and the regular quadrilateral far from the center is a second regular quadrilateral.

[0015] The second circular groove is inscribed in the first regular quadrilateral, and the diagonal groove is provided in plurality, each of the diagonal grooves extends from the center to the second regular quadrilateral.

[0016] In a preferred embodiment of the present application, the first groove structure further comprises a connecting groove.

[0017] The connecting groove is provided in plurality, and the plurality of connecting grooves are arranged at intervals along the circumferential direction of the damping elastomer, and the first groove structure is in communication with the spiral line of the corresponding second groove structure through each connecting groove.

[0018] In a preferred embodiment of the present application, the cross-sectional shape of the first groove structure and the second groove structure is the same, and the cross-sectional shape of the first groove structure and the second groove structure is semicircular, semi-elliptical, trapezoidal or V-shaped.

[0019] In a preferred embodiment of the present application, the included angle of the two sides of the V-shaped structure of the first groove structure and the second groove structure ranges from 15° to 22°, the opening ranges from 0.1mm to 2mm, and the sharp corner of the V-shaped structure is transitioned by chamfering.

[0020] In a preferred embodiment of the present application, the damping shell comprises a damping shell, a damping end cover and a sealing ring.

[0021] The damping end cover is sealingly connected to one end of the damping shell through the sealing ring, the liquid outlet is located on the damping end cover, and the damping end cover is in communication with the first groove structure through the liquid outlet.

[0022] In a preferred embodiment of the present application, a pressure sensor is further included.

[0023] The pressure sensor is sealingly connected to the end of the damping shell away from the damping end cover, and the liquid inlet is provided at the end of the damping shell close to the pressure sensor.

[0024] In the preferred embodiment of the present application, the liquid inlet adopts a U-shaped pipeline, and the inlet end of the liquid inlet is located on the side wall of the damping shell.

[0025] The liquid inlet is in communication with the pressure sensor, and the diameter of the pipeline connecting the liquid inlet and the detection point of the pressure sensor is greater than 2 mm.

[0026] The present application provides a liquid chromatograph comprising the mixing and damping device.

[0027] The mixing and damping device comprises a damping shell and a damping elastic body. The damping shell is provided with a sealed cavity, and the damping elastic body is accommodated in the sealed cavity, and the side wall of the damping elastic body is attached to the inner wall of the damping shell. The two ends of the damping shell are respectively provided with a liquid inlet and a liquid outlet. The damping elastic body is provided with a first groove structure corresponding to the end surface of the damping shell. The first groove structure is in communication with the liquid inlet and the liquid outlet, respectively. The damping elastic body is provided with a second groove structure corresponding to the circumferential side wall of the inner wall of the damping shell. The first groove structure and the second groove structure are in communication. Specifically, the first groove structure receives high-pressure liquid through the liquid inlet. The flow of the first groove structure and the second groove structure can mix and homogenize the reagent of the high-pressure liquid. When the high-pressure liquid gradually fills the first groove structure and the second groove structure, the pressure gradually increases after being subjected to the resistance of the load end. The high-pressure liquid in the first groove structure and the second groove structure presses the damping elastic body, so that the cross-sectional area of the first groove structure and the second groove structure expands. When the pressure is basically stable, the volume formed by the first groove structure and the second groove structure remains relatively stable. By using the deformation of the first groove structure and the second groove structure of the damping elastic body to store high-pressure liquid, the pressure peak is reduced. When the output of the high-pressure pump is at a low point, the damping elastic body reduces the volume of the first groove structure and the second groove structure under its own deformation. The damping elastic body discharges the high-pressure liquid to compensate for the sudden pressure valley. When the mobile phase pressure valley flows through the damping elastic body, it is compensated, thereby achieving the suppression of the pulsation of the mobile phase pressure in the high-pressure pump liquid system. At the same time, the mixing and homogenization of the reagent of the high-pressure liquid are also satisfied, the analysis precision is met, and the technical problems of the damping device in the prior art, such as the need for a separate mixing device to extend the gradient response time and affect the analysis precision, are solved. BRIEF DESCRIPTION OF DRAWINGS

[0028] In order to more clearly illustrate the specific embodiments of the present application or the technical solutions in the prior art, the following will briefly introduce the drawings needed to be used in the specific embodiments or prior art description. Obviously, the drawings in the following description are some embodiments of the present application, and those skilled in the art can also obtain other drawings according to these drawings without creating any creative labor.

[0029] Figure 1 This is an exploded view of the overall structure of the mixing damper provided in an embodiment of the present invention.

[0030] Figure 2 This is a schematic diagram of the internal structure of the mixing damper provided in an embodiment of the present invention;

[0031] Figure 3 A schematic cross-sectional view of the mixing damper without a pressure sensor provided in an embodiment of the present invention;

[0032] Figure 4 This is a schematic diagram of the overall cross-sectional structure of the mixing damper provided in an embodiment of the present invention;

[0033] Figure 5 for Figure 4 A partially enlarged structural diagram of the mixing damper at position A provided in the embodiment;

[0034] Figure 6 for Figure 4 A partially enlarged structural diagram of the mixing damper at position B provided in the embodiment;

[0035] Figure 7 for Figure 4 A partially enlarged structural diagram of the mixing damper at position C provided in the embodiment;

[0036] Figure 8 for Figure 7 A schematic diagram of the pressure sealing gasket of the pressure sensor in the embodiment of the mixing damper;

[0037] Figure 9 A schematic diagram of the first groove structure of the damping elastic body of the mixing damper provided in an embodiment of the present invention;

[0038] Figure 10 This is a schematic planar structure diagram of another embodiment of the first groove structure of the damping elastomer of the mixing damper provided in the present invention.

[0039] Icons: 100-Damping housing; 101-Damping outer shell; 111-Inlet; 102-Damping end cap; 112-Outlet; 103-Sealing ring; 200-Damping elastomer; 201-First groove structure; 211-Involute circular groove; 221-First straight groove; 231-Second straight groove; 241-First circular groove; 251-Second circular groove; 261-Slanted groove; 271-Connecting groove; 202-Second groove structure; 300-Pressure sensor; 301-Pressure sensor body; 302-Pressure sensor output line; 303-Pressure sealing gasket. Detailed Implementation

[0040] The technical solutions of the present application will be described clearly and completely below in connection with the embodiments. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all the other embodiments obtained by those skilled in the art without creative work are within the protection scope of the present application.

[0041] As shown in Figures 1-10 The present embodiment provides a mixed uniform damper, which comprises a damping shell 100 and a damping elastic body 200; the damping shell 100 is provided with a sealed cavity, the damping elastic body 200 is accommodated in the sealed cavity, and the side wall of the damping elastic body 200 is attached to the inner wall of the damping shell 100; the two ends of the damping shell 100 are respectively provided with a liquid inlet 111 and a liquid outlet 112, the end surface of the damping shell 100 is provided with a first groove structure 201, the first groove structure 201 is respectively communicated with the liquid inlet 111 and the liquid outlet 112, the inner wall circumferential side wall of the damping shell 100 is provided with a second groove structure 202, and the first groove structure 201 and the second groove structure 202 are communicated.

[0042] It should be noted that the mixing damper provided in the embodiment can mix and deliver the high-pressure liquid output by the high-pressure pump and maintain the pressure damping effect. Specifically, the damping shell 100 can be made of stainless steel or engineering plastic, the damping elastic body 200 can be made of elastic engineering plastic or synthetic rubber, and the damping shell 100 and the damping elastic body 200 can be in interference fit, that is, the damping shell 100 and the damping elastic body 200 can only be delivered through the second groove structure 202, the damping shell 100 can receive the high-pressure liquid delivered by the high-pressure pump through the liquid inlet 111, the high-pressure liquid can be mixed and delivered inside the first groove structure 201 and the second groove structure 202, and the mixing and delivery of the high-pressure liquid as a reagent are ensured; when the high-pressure liquid is injected into the first groove structure 201 and the second groove structure 202, the first groove structure 201 and the second groove structure 202 are gradually filled, and after being subjected to the resistance of the load end, the pressure gradually increases, at this time, the high-pressure liquid in the first groove structure 201 and the second groove structure 202 presses the damping elastic body 200, so that the cross-sectional area of the first groove structure 201 and the second groove structure 202 is expanded, and when the pressure is basically stable, the volume formed by the first groove structure 201 and the second groove structure 202 is kept relatively stable, and when the pulsating pressure output by the high-pressure pump further squeezes the elastic body, the volume of the first groove structure 201 and the second groove structure 202 becomes larger, more high-pressure liquid is stored, and the pressure peak is reduced. When the high-pressure pump outputs the trough, the pressure becomes low, the damping elastic body 200 expands, the volume of the first groove structure 201 and the second groove structure 202 becomes small, the damping elastic body 200 can discharge the high-pressure liquid, there will be some small pressure fluctuations, and the pressure and flow are synchronous fluctuations, that is, the output flow has some small fluctuations; at this time, the ripple of the fluctuation is very small, and through a specific micro-flow meter, the ripple is less than 1 / 80 of the average flow, which can meet the requirements of analysis precision; by connecting the mixing damper in series in the high-pressure reagent pipeline, the problem of reagent stagnation in the parallel pipeline can be overcome, and after replacing the reagent, the original reagent will be discharged from the first groove structure 201 and the second groove structure 202, so there is no problem of different reagent stagnation and mixing.

[0043] The mixing and uniformity damper provided by the embodiment comprises a damping shell 100 and a damping elastic body 200; the damping shell 100 is provided with a sealed cavity, the damping elastic body 200 is accommodated in the sealed cavity, and the side wall of the damping elastic body 200 is attached to the inner wall of the damping shell 100; the damping shell 100 is respectively provided with a liquid inlet 111 and a liquid outlet 112 at two ends, the liquid inlet 111 is below, and the liquid outlet 112 is at the upper end, which is helpful for smoothly discharging air; the damping elastic body 200 is provided with a first groove structure 201 corresponding to the end surface of the damping shell 100, the first groove structure 201 is respectively communicated with the liquid inlet 111 and the liquid outlet 112, the damping elastic body 200 is provided with a second groove structure 202 corresponding to the circumferential side wall of the inner wall of the damping shell 100, and the first groove structure 201 and the second groove structure 202 are communicated; specifically, the high-pressure liquid is received through the liquid inlet 111 by the first groove structure 201, the flow of the first groove structure 201 and the second groove structure 202 can mix and uniform the reagent of the high-pressure liquid, when the high-pressure liquid gradually fills the first groove structure 201 and the second groove structure 202, the pressure gradually increases after being subjected to the resistance of the load end, the high-pressure liquid in the first groove structure 201 and the second groove structure 202 compresses the damping elastic body 200, so that the cross-sectional area of the first groove structure 201 and the second groove structure 202 is expanded, when the pressure is basically stable, the volume formed by the first groove structure 201 and the second groove structure 202 is relatively stable; the high-pressure liquid is stored by the deformation of the first groove structure 201 and the second groove structure 202 of the damping elastic body 200, so as to reduce the pressure peak, when the output of the high-pressure pump is at a trough, the damping elastic body 200 reduces the volume of the first groove structure 201 and the second groove structure 202 under the action of its own deformation, the damping elastic body 200 discharges the high-pressure liquid, so as to compensate the sudden pressure valley, so that the flow phase pressure valley flowing through the damping elastic body 200 is compensated, the pulsation of the flow phase pressure in the high-pressure pump liquid path system is inhibited, the mixing and uniformity of the reagent of the high-pressure liquid is satisfied, the requirement of analysis precision is satisfied, and the technical problem that the damper in the prior art cannot satisfy the mixing and uniformity requirement, a separate mixing device is needed to prolong the gradient response time and affect the analysis precision is solved.

[0044] On the basis of the above embodiment, further, in the preferred embodiment of the present application, the damping elastic body 200 is in a cylindrical structure, the first groove structure 201 is respectively arranged on the end surface of the damping elastic body 200 in the cylindrical structure, and the second groove structure 202 is arranged along the circumferential side wall of the damping elastic body 200 in the cylindrical structure.

[0045] In the embodiment, the first groove structure 201 is provided with two groups, and the two groups of first groove structure 201 are arranged on the two end surfaces of the damping elastic body 200. One group of first groove structure 201 can communicate with the liquid inlet 111, that is, the first groove structure 201 can receive the high-pressure liquid delivered by the liquid inlet 111, and the other group of first groove structure 201 can communicate with the liquid outlet 112, that is, the first groove structure 201 can discharge the high-pressure liquid in the damping shell 100.

[0046] In the preferred embodiment of the present application, the first groove structure 201 extends along the end surface of the damping elastic body 200 in the form of a plurality of intersecting spiral lines; the second groove structure 202 extends along the circumferential surface of the damping elastic body 200 in the form of a plurality of spiral lines in opposite directions, and the second groove structure 202 is arranged in communication with the first groove structure 201 at both ends of the damping elastic body 200.

[0047] In the embodiment, the first groove structure 201 extends along the end surface of the damping elastic body 200 in the form of a plurality of intersecting spiral lines, that is, when the high-pressure liquid delivered by the liquid inlet 111 enters the first groove structure 201, the high-pressure liquid is mixed and averaged multiple times in the process of being transported in multiple intersecting spiral lines. Further, the second groove structure 202 extends along the circumferential surface of the damping elastic body 200 in the form of a plurality of spiral lines in opposite directions, that is, after the high-pressure liquid is mixed and averaged in the first groove structure 201, the high-pressure liquid can be mixed and averaged with each other in a plurality of spiral lines in opposite directions after entering the second groove structure 202. Finally, the high-pressure liquid that has been mixed and averaged in the second groove structure 202 can be finally mixed and averaged in the first groove structure 201 at the other end, so that the reagent can be mixed and averaged multiple times in the process of being transported.

[0048] Alternatively, the first groove structure 201 can have various arrangements of intersecting spiral lines; for example, Figure 9 As shown in the preferred embodiment of the present application, the first groove structure 201 includes two groups of involute circular grooves 211 in opposite directions, each group of involute circular grooves 211 includes 2-8 involute circles, each involute circle has 0.5-2 circumferential lines of involute spiral lines, and each group of involute circular grooves 211 includes 2-6 involute spiral lines in opposite directions.

[0049] In the embodiment, the first groove structure 201 can be composed of two groups of involute circular grooves 211 with opposite directions; each group has 2 to 8 involute circles, each involute circle starts from a small circle at the center of the end face of the damping elastomer 200 of the cylindrical structure, and ends at a circle with a diameter slightly smaller than the outer circle of the damping elastomer 200, and the involute spiral line is a circle, wherein 0.5 to 2 circles can be used, and when the number of circles of the spiral line is too large, the included angle formed will be too small, which will affect the mechanical strength of the first groove structure 201; wherein each circle has 2-6 involute circles with opposite directions in each group, preferably 4, so that the included angle of the groove is not too small, so that the damping elastomer 200 has sufficient strength, and the intersection points of the first groove structure 201 are the most.

[0050] As shown in the preferred embodiment of the present application, Figure 10 The first groove structure 201 includes a first straight groove 221, a second straight groove 231, a first circular groove 241, a second circular groove 251, and an oblique groove 261; the first circular groove 241 and the second circular groove 251 are concentrically arranged with the end of the damping elastomer 200, the first straight groove 221 and the second straight groove 231 are provided in multiple, the multiple first straight grooves 221 are arranged at equal intervals in the area surrounded by the first circular groove 241, the multiple second straight grooves 231 are arranged at equal intervals in the area surrounded by the first circular groove 241, and each first straight groove 221 and each second straight groove 231 are arranged vertically, so that the first straight grooves 221 and the second straight grooves 231 spread from the center of the first circular groove 241 to form multiple regular quadrilaterals, wherein the regular quadrilaterals close to the center are first regular quadrilaterals, and the regular quadrilaterals away from the center are second regular quadrilaterals; the second circular groove 251 is inscribed in the first regular quadrilateral, and the oblique groove 261 is provided in multiple, each oblique groove 261 extends from the center to the second regular quadrilateral.

[0051] In the embodiment, the edge position of the first groove structure 201 is determined by the first circular groove 241, the groove is processed inside the first circular groove 241, the first linear groove 221 and the second linear groove 231 are vertically arranged in a cross shape, the innermost square formed by the first linear groove 221 and the second linear groove 231 is processed to form a second circular arc groove to form an inscribed circle, and a plurality of diagonal grooves 261 are processed with the center of the circular damping elastomer 200, wherein the pitch of the diagonal groove 261 can be greater than the pitch of the first linear groove 221, the second linear groove 231, the first circular groove 241 and the second circular groove 251, that is, a plurality of intersection points can be formed by the first linear groove 221, the second linear groove 231, the first circular groove 241, the second circular groove 251 and the diagonal groove 261 to mix, optionally, the second circular groove 251 can also be provided with a plurality of grooves according to the end area of the damping elastomer 200, so as to increase the intersection points of the diagonal groove 261 and the second circular groove 251, and the mixing of the reagent is completed by the plurality of cross grooves.

[0052] Optionally, the pattern of the first groove structure 201 can also be provided with a plurality of patterns, as long as the damping elastomer 200 has sufficient strength, the grooves are mixed as much as possible; preferably, the first groove structure 201 comprises two groups of structures of involute circular grooves 211 in opposite directions, that is, each groove is in arc shape, which can ensure the mixing of the intersection on the basis of conveying, and when the type of reagent is changed, since each involute spiral line of the involute circular groove 211 forms intercommunication, the new reagent can squeeze out all the original reagents, and the discharge effect is best; it should be noted that as long as the first groove structure 201 can meet the cross pattern, the mixing requirement can be realized, and it belongs to the limitation of the embodiment.

[0053] In the preferred embodiment of the application, the first groove structure 201 further comprises a connecting groove 271; the connecting groove 271 is provided with a plurality of connecting grooves 271, and the plurality of connecting grooves 271 are arranged in the circumferential direction of the damping elastomer 200, and the first groove structure 201 is communicated with the spiral line of the corresponding second groove structure 202 through each connecting groove 271.

[0054] In the embodiment, the connecting groove 271 can be arranged in the circumferential direction of the damping elastomer 200, and each connecting groove 271 can correspond to a spiral line of the second groove structure 202, wherein the cross-sectional area of the connecting groove 271 can be greater than the cross-sectional area of the spiral line of the first groove structure 201, so as to ensure that the connecting groove 271 can ensure that the high-pressure liquid after mixing in the first groove structure 201 enters the spiral line of the second groove structure 202.

[0055] In the preferred embodiment of the present application, the cross-sectional shape of the first groove structure 201 and the second groove structure 202 is the same, and the cross-sectional shape of the first groove structure 201 and the second groove structure 202 is semicircular, semi-elliptical, trapezoidal or V-shaped.

[0056] In the present embodiment, the cross-sectional shape of the first groove structure 201 and the second groove structure 202 can adopt a structure of being narrow at the bottom and wide at the top, i.e. the spacing near the inner wall of the damping elastomer 200 is smaller than the spacing away from the damping elastomer 200, so that the first groove structure 201 and the second groove structure 202 can be extruded with increased area after being pressed by the high-pressure liquid.

[0057] Preferably, the cross-sectional shape of the first groove structure 201 and the second groove structure 202 is a V-shaped groove, and in the preferred embodiment of the present application, the included angle of the two sides of the V-shaped structure of the first groove structure 201 and the second groove structure 202 ranges from 15° to 22°, the opening ranges from 0.1 mm to 2 mm, and the sharp corner of the V-shaped structure is transitioned by chamfering.

[0058] Preferably, the V-shaped structure can adopt a single groove cross-sectional area with an opening of 1 mm at the top and an included angle of 18°, and in addition, the delivery cross-sectional area of the first groove structure 201 and the second groove structure 202 needs to be less than twice the cross-sectional area of the high-pressure pump output pipeline of the chromatograph.

[0059] Specifically, when the high-pressure liquid is injected into the groove of the V-shaped structure, gradually filling the entire V-shaped structure, after being resisted by the load end, the pressure gradually increases, at this time, the high-pressure liquid in the V-shaped structure presses the damping elastomer 200, so that the cross-sectional area of the V-shaped structure expands, at the same time, the high-pressure liquid is extruded from the liquid inlet 111 to the bottom surface of the cylinder of the damping elastomer 200, the end surface forms a triangular gap, and when the pressure is basically stable, the volume formed by the triangular gap and the V-shaped structure remains relatively stable; after the triangular gap is formed at the bottom end of the cylinder of the damping elastomer 200, part of the high-pressure liquid is higher than the V-shaped structure of the end surface, but the high-pressure liquid presses the end surface of the cylinder of the damping elastomer 200, and the corresponding pressure is transmitted to the cylinder of the damping elastomer 200, so that the cylinder is extruded towards the circumference, the high-pressure liquid extrudes the V-shaped structure, and forms pressure on the two side walls of the V-shaped structure, and also extrudes the cylinder of the damping elastomer 200, so that the cylinder of the damping elastomer 200 is tightly pressed with the damping shell 100, the high-pressure liquid will not overflow outside the V-shaped structure, and the high-pressure liquid will be mixed multiple times in the V-shaped structure on the surface of the cylinder of the damping elastomer 200 and the V-shaped structure at the bottom end, so that the liquid with general viscosity can be mixed uniformly; since the high-pressure reagent liquid enters from the liquid inlet 111, and the pressure at the liquid outlet 112 is less than that at the liquid inlet 111, i.e. the triangular gap is only formed at the end surface of the cylinder of the damping elastomer 200 close to the liquid inlet 111, under the influence of the high-pressure liquid, the vertical surface and the top end plane of the cylinder of the damping elastomer 200 will generally be tightly attached to the damping shell 100, so as to ensure that the reagent will flow, cross and impact in the V-shaped structure, and then obtain a very uniformly mixed reagent.

[0060] It should be noted that the relatively shallow recesses such as the circular arc-shaped groove and the elliptical groove may form a centripetal pressure on the cylinder of the damping elastomer 200, so that the diameter of the cylinder of the damping elastomer 200 is reduced, and the reagent overflows onto the surface of the cylinder of the damping elastomer 200, reducing the uniformity of mixing.

[0061] Further, when the pulsating pressure output by the high-pressure pump further squeezes the damping elastic body 200, the V-shaped structure volume becomes larger, and the excessively high pressure, i.e., the high-pressure liquid, is absorbed; when the micro high-pressure pump outputs at a low point, the pressure slightly decreases, the damping elastic body 200 shrinks, the V-shaped structure volume becomes smaller, the mixed damping device can continue to output the high-pressure liquid, the high-pressure pump continuously operates, and the pressure at the output end of the mixed damping device has some small pressure fluctuations, and the pressure and flow are synchronously fluctuated, so that the output flow has some small fluctuations; however, the ripple of the fluctuations is very small, and when the amplitude is less than 1 / 80 of the average flow, the precision requirement can be met. Specifically, when the total volume of the V-shaped structure without high pressure is greater than 30 times the cylinder capacity of the high-pressure pump, and after the rated high pressure is added, the total volume of the V-shaped structure should be increased to 90 times or more, so that better damping effect can be achieved.

[0062] Optionally, the damping elastic body 200 can be machined by a numerical control machining center using engineering plastics such as polytetrafluoroethylene (PTFE), polyether ether ketone (PEEK), polyphenylene sulfide (PPS), or polyoxymethylene (POM), or can be injection molded or molded; in addition, a relatively hard and elastic synthetic rubber such as polyurethane rubber, fluorosilicone rubber, butadiene-acrylonitrile rubber, and silicone rubber can be selected for molding.

[0063] In the preferred embodiment of the present application, the damping shell 100 comprises a damping shell 101, a damping end cover 102, and a sealing ring 103; the damping end cover 102 is sealingly connected to one end of the damping shell 101 through the sealing ring 103, the liquid outlet 112 is located on the damping end cover 102, and the damping end cover 102 is in communication with the first groove structure 201 through the liquid outlet 112.

[0064] In the embodiment, the damping end cover 102 is sealingly connected to the damping shell 101, wherein the sealing ring 103 can ensure the sealing requirement of the damping shell 101 and the sealing end cover; the liquid outlet 112 can be located at the center position of the damping end cover 102, the liquid inlet 111 can be located at the end of the damping shell 101 or can be arranged at the side wall position of the damping shell 101.

[0065] In the preferred embodiment of the present application, the pressure sensor 300 can also be included; the pressure sensor 300 is sealingly connected to the end of the damping shell 101 away from the damping end cover 102, and the liquid inlet 111 is arranged at the end of the damping shell 101 close to the pressure sensor 300.

[0066] In the embodiment, the pressure sensor 300 can include a pressure sensor body 301, a pressure sensor output line 302 and a pressure sealing gasket 303, wherein the pressure sensor body 301 is located at one end of the damping shell 101 close to the liquid inlet 111, and the liquid inlet 111 needs to be communicated with the pressure detection point of the pressure sensor 300; in addition, the pressure sealing gasket 303 needs to be aligned with the pipeline part, so that the positioning pin hole can be provided on the pressure sealing gasket 303, and the positioning pin is used for connection and fixation.

[0067] In the preferred embodiment of the application, the liquid inlet 111 adopts a U-shaped pipeline, and the inlet end of the liquid inlet 111 is located on the side wall of the damping shell 101; the liquid inlet 111 is communicated with the pressure sensor 300, and the pipeline diameter connected with the detection point of the pressure sensor 300 is greater than 2 mm.

[0068] Specifically, since the liquid chromatograph reagent pipeline requires strict exclusion of air, if the diameter of the vertically downward curved and horizontal pipeline is too small, air bubbles are easily adsorbed and difficult to remove, the liquid inlet 111 adopts a U-shaped pipeline, in order to ensure that the volume inside the damping shell 100 is small, so that the reagent can be quickly replaced, it is required that the pipeline and the V-shaped structure inside are as small as possible, and the pipeline diameter is less than 1 mm, therefore, the pipeline diameter connected with the detection point of the pressure sensor 300 should be greater than 2 mm, so as to ensure that no air bubbles are left when the liquid is injected, and all air can be smoothly discharged.

[0069] It should be noted that the mixed-damping damper provided in the embodiment should be cleaned of grease before assembly, and after installation, anhydrous alcohol is first poured on the test bench, and the grease is continuously cleaned, and then pure water is poured to test the pressure and the flow ripple of the damper, and the product can be qualified after meeting the requirements.

[0070] The liquid chromatograph provided in the embodiment includes the mixed-damping damper; since the technical effect of the liquid chromatograph provided in the embodiment is the same as that of the mixed-damping damper provided in the above embodiment, this will not be described here.

[0071] Finally, it should be noted that: the above embodiments are only used to illustrate the technical solutions of the application, but not to limit them; although the application has been described in detail with reference to the above embodiments, those skilled in the art should understand that the technical solutions recorded in the above embodiments can still be modified, or some or all of the technical features can be replaced by equivalents; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the application.

Claims

1. A hybrid damper, characterized by, include: Damping housing (100) and damping elastomer (200); The damping housing (100) is provided with a sealed cavity, the damping elastomer (200) is housed in the sealed cavity, and the sidewall of the damping elastomer (200) is in contact with the inner wall of the damping housing (100); The damping housing (100) has an inlet (111) and an outlet (112) at its two ends, respectively. The damping elastomer (200) has a first groove structure (201) on the end surface of the damping housing (100), and the first groove structure (201) is connected to the inlet (111) and the outlet (112) respectively. The damping elastomer (200) has a second groove structure (202) on the inner circumferential side wall of the damping housing (100), and the first groove structure (201) and the second groove structure (202) are connected. The damping housing (100) and the damping elastomer (200) are fitted with an interference fit, and the damping housing (100) and the damping elastomer (200) can only be conveyed through the second groove structure (202); The damping elastomer (200) is characterized in that it has a cylindrical structure, and the first groove structure (201) is respectively disposed on the two end surfaces of the cylindrical damping elastomer (200). The first groove structure (201) extends along the end surface of the damping elastomer (200) in a plurality of intersecting spiral lines. The second groove structure (202) extends along the circumferential sidewall of the cylindrical damping elastomer (200); the second groove structure (202) extends along the circumferential surface of the damping elastomer (200) in multiple spiral lines in opposite directions, and the second groove structure (202) is connected to the first groove structure (201) at both ends of the damping elastomer (200); The first groove structure (201) includes a first straight groove (221), a second straight groove (231), a first circular groove (241), a second circular groove (251), and an oblique groove (261). The first circular groove (241) and the second circular groove (251) are both concentrically arranged with the end of the damping elastomer (200). There are multiple first straight grooves (221) and second straight grooves (231). Multiple first straight grooves (221) are arranged at equal intervals in the area enclosed by the first circular groove (241). Multiple second straight grooves (231) are arranged at equal intervals in the area enclosed by the first circular groove (241). Each first straight groove (221) and each second straight groove (231) are arranged vertically so that the first straight grooves (221) and the second straight grooves (231) spread out from the center of the first circular groove (241) to form multiple regular quadrilaterals. The regular quadrilaterals closer to the center are the first regular quadrilaterals, and the regular quadrilaterals farther from the center are the second regular quadrilaterals. The second circular groove (251) is inscribed in a first square, and the diagonal grooves (261) are provided in multiple, each diagonal groove (261) extending from the center of the circle to the second square; The first groove structure (201) further comprises a connecting groove (271); The connecting grooves (271) are provided in multiple, and the multiple connecting grooves (271) are arranged at intervals along the circumferential direction of the damping elastomer (200), and the first groove structure (201) is in communication with the spiral line of the corresponding second groove structure (202) through each connecting groove (271).

2. The hybrid damper of claim 1, wherein The cross-sectional shape of the first groove structure (201) and the second groove structure (202) is the same, and the cross-sectional shape of the first groove structure (201) and the second groove structure (202) is semicircular, semi-elliptical, trapezoidal or V-shaped. The included angle of the two sides of the V-shaped structure of the first groove structure (201) and the second groove structure (202) ranges from 15° to 22°, the opening ranges from 0.1mm to 2mm, and the sharp corner of the V-shaped structure is transitioned by chamfering.

3. The hybrid damper of claim 1, wherein, The damping shell (100) comprises a damping shell (101), a damping end cover (102) and a sealing ring (103); The damping end cover (102) is sealingly connected to one end of the damping shell (101) through the sealing ring (103), the liquid outlet (112) is located on the damping end cover (102), and the damping end cover (102) is in communication with the first groove structure (201) through the liquid outlet (112).

4. The hybrid damper of claim 3, wherein, Further comprising a pressure sensor (300); The pressure sensor (300) is sealingly connected to the end of the damping shell (101) away from the damping end cover (102), and the liquid inlet (111) is provided at the end of the damping shell (101) close to the pressure sensor (300).

5. The hybrid damper of claim 4, wherein, The liquid inlet (111) adopts a U-shaped pipeline, and the inlet end of the liquid inlet (111) is located on the side wall of the damping shell (101); The liquid inlet (111) is in communication with the pressure sensor (300), and the diameter of the pipeline connecting the liquid inlet (111) and the detection point of the pressure sensor (300) is greater than 2mm.

6. A liquid chromatograph characterized by, A mixing damper comprising the mixing damper according to any one of claims 1-5.

Images