Noise Processing Method for Triple Quadrupole Mass Spectrometer System

Abstract

The present invention provides a noise processing method for a triple quadrupole mass spectrometer system, which first calibrates the power supply voltage of a target triple quadrupole mass spectrometer system and a reference triple quadrupole mass spectrometer system, and obtains the inherent noise of a signal processing circuit board respectively connected to the two mass spectrometer systems and the environmental noise difference information between the two mass spectrometer systems; then, according to the inherent noise and environmental noise difference information, the target triple quadrupole mass spectrometer system performs noise reduction processing on the mass spectrometry detection signal of a sample to be tested. The method additionally sets a reference triple quadrupole mass spectrometer system as a reference benchmark for signal noise reduction processing, which is different from the prior art that amplifies and performs analog-to-digital conversion filtering processing on the mass spectrometry detection signal, and provides an accurate reference benchmark for the mass spectrometry detection signal, thereby maximally filtering and removing the inherent noise components and environmental noise components of the mass spectrometry detection signal and improving the detection accuracy and reliability of the mass spectrometer.

Description

Technical Field

[0001] The present invention relates to the technical field of mass spectrometer signal processing, and in particular to a noise processing method for a triple quadrupole mass spectrometer system. Background Art

[0002] The triple quadrupole mass spectrometer has the characteristics of high sensitivity, fast analysis speed and small sample consumption, and is widely used in the fields of medicine and biological analysis. After the sample is ionized by electrospray, it enters the multiple detection channels of the triple quadrupole mass spectrometer for mass spectrometry analysis, so that different components of the sample can be detected and analyzed simultaneously, thereby realizing multi-channel analysis of the sample. The mass spectrometry detection signal obtained by the triple quadrupole mass spectrometer for mass spectrometry detection of the sample will be output to the signal processing circuit board for processing, but the active devices inside the signal processing circuit board will generate self-oscillation noise. At the same time, the triple quadrupole mass spectrometer will be interfered by noise from the external environment during operation. The above two noises will interfere with the mass spectrometry detection signal output by the mass spectrometer, thereby affecting the detection accuracy and reliability of the mass spectrometer. Summary of the invention

[0003] In view of the defects of the prior art, the present invention provides a noise processing method for a triple quadrupole mass spectrometer system, which first calibrates the power supply voltage of a target triple quadrupole mass spectrometer system and a reference triple quadrupole mass spectrometer system, and obtains the inherent noise of a signal processing circuit board respectively connected to the two mass spectrometer systems and the environmental noise difference information between the two mass spectrometer systems; then, according to the above inherent noise and environmental noise difference information, the target triple quadrupole mass spectrometer system performs noise reduction processing on the mass spectrometry detection signal of a sample to be tested. The above method additionally sets a reference triple quadrupole mass spectrometer system as a reference benchmark for signal noise reduction processing, which is different from the prior art that amplifies and performs analog-to-digital conversion filtering processing on the mass spectrometry detection signal, and provides an accurate reference benchmark for the mass spectrometry detection signal, thereby maximally filtering and removing the inherent noise components and environmental noise components of the mass spectrometry detection signal and improving the detection accuracy and reliability of the mass spectrometer.

[0004] The present invention provides a noise processing method for a triple quadrupole mass spectrometer system, which comprises the following steps:

[0005] Step S1, placing preset standard samples in a target triple quadrupole mass spectrometer system and a reference triple quadrupole mass spectrometer system for mass spectrometry detection, respectively, and calibrating the power supply voltages of the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system according to first mass spectrometry detection signals and second mass spectrometry detection signals outputted by the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system respectively;

[0006] Step S2, after the power supply voltage calibration is completed, obtaining the first signal and the second signal output by the first signal processing circuit board and the second signal processing circuit board respectively connected to the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system; determining the first inherent noise and the second inherent noise of the first signal processing circuit board and the second signal processing circuit board respectively according to the first signal and the second signal;

[0007] Step S3, after the power supply voltage calibration is completed, obtaining a third mass spectrometry detection signal and a fourth mass spectrometry detection signal outputted by the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system for mass spectrometry detection of a preset standard sample; determining environmental noise difference information between the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system according to the first inherent noise, the second inherent noise, the third mass spectrometry detection signal and the fourth mass spectrometry detection signal;

[0008] Step S4, after the power supply voltage calibration is completed, the sample to be tested is placed in the target triple quadrupole mass spectrometer system for mass spectrometry detection, and a fifth mass spectrometry detection signal correspondingly output by the target triple quadrupole mass spectrometer system is obtained; and the fifth mass spectrometry detection signal is subjected to noise reduction processing according to the first inherent noise, the second inherent noise and the environmental noise difference information.

[0009] Further, in the step S1, the preset standard samples are placed in the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system for mass spectrometry detection, and the power supply voltages of the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system are calibrated according to the first mass spectrometry detection signal and the second mass spectrometry detection signal outputted by the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system, which specifically includes:

[0010] Step S101, placing preset standard samples of the same weight in a target triple quadrupole mass spectrometer system and a reference triple quadrupole mass spectrometer system respectively for mass spectrometry detection, and synchronously inputting the same operating voltage to the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system during the mass spectrometry detection process;

[0011] Step S102, acquiring a first mass spectrometry detection signal and a second mass spectrometry detection signal respectively output by the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system when driven by the same operating voltage;

[0012] Step S103, extracting the peak detection sub-signals contained in the first mass spectrometry detection signal and the second mass spectrometry detection signal; performing signal amplitude comparison between the peak detection sub-signals and the inherent mass spectrometry peak distribution signal of the preset standard sample; and then calibrating the power supply voltages of the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system according to the result of the signal amplitude comparison.

[0013] Further, in step S103, according to the result of the signal amplitude comparison, calibrating the power supply voltage of the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system specifically includes:

[0014] Obtaining the amplitude difference between the half-peak amplitude of the peak detection sub-signal and the half-peak amplitude of the inherent mass spectrum peak distribution signal;

[0015] According to the amplitude difference, the operating voltage output to the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system is adjusted; when after the operating voltage is adjusted, the re-determined amplitude difference is less than or equal to the preset difference threshold, the adjusted operating voltage is used as the correction power supply voltage for the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system.

[0016] Further, in step S2, after the power supply voltage calibration is completed, obtaining the first signal and the second signal output by the first signal processing circuit board and the second signal processing circuit board respectively connected to the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system specifically includes:

[0017] Inputting the calibration power supply voltage to the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system, while the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system perform mass spectrometry detection on preset standard samples of the same weight;

[0018] Then, a first signal and a second signal outputted from mass spectrometry detection by a first signal processing circuit board and a second signal processing circuit board connected to the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system respectively are obtained.

[0019] Further, in the step S2, determining the first inherent noise and the second inherent noise of the first signal processing circuit board and the second signal processing circuit board respectively according to the first signal and the second signal specifically includes:

[0020] The following formula (1) is used to simulate and reproduce the first inherent noise amplitude or the second inherent noise amplitude corresponding to the first signal processing circuit board or the second signal processing circuit board according to the first signal or the second signal.

[0021]

[0022] In the above formula (1), X represents the first inherent noise amplitude or the second inherent noise amplitude of analog reproduction; D(t) represents the digital noise signal amplitude generated by the first signal processing circuit board or the second signal processing circuit board at time t; t 0 represents the power-on time of the first signal processing circuit board or the second signal processing circuit board; T represents the duration of collecting the first signal or the second signal from the first signal processing circuit board or the second signal processing circuit board; Indicates the time t 0 At time t 0 +T between the mode of the amplitude of the digital noise signal generated by the first signal processing circuit board or the second signal processing circuit board; Indicates the time t 0 At time t 0 +T between the minimum value of the digital noise signal amplitude generated by the first signal processing circuit board or the second signal processing circuit board; Indicates the time t 0 At time t 0 +T is the maximum value of the amplitude of the digital noise signal generated by the first signal processing circuit board or the second signal processing circuit board.

[0023] Further, in the step S3, determining the environmental noise difference information between the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system according to the first inherent noise, the second inherent noise, the third mass spectrometer detection signal and the fourth mass spectrometer detection signal specifically includes:

[0024] The environmental noise difference value between the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system is obtained by using the following formula (2) according to the first inherent noise amplitude, the second inherent noise amplitude, the digital signal amplitude of the third mass spectrometer detection signal, and the digital signal amplitude of the fourth mass spectrometer detection signal:

[0025]

[0026] In the above formula (2), H represents the difference in environmental noise between the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system; G 1 (t) represents the digital signal amplitude of the third mass spectrometer detection signal output by the target triple quadrupole mass spectrometer system at time t; G 2 (t) represents the digital signal amplitude of the fourth mass spectrometer detection signal output by the reference triple quadrupole mass spectrometer system at time t; X(1) represents the first inherent noise amplitude; X(2) represents the second inherent noise amplitude; t p represents the common power-on moment of the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system; Indicates the time t p At time t p +The maximum value in brackets between T; Indicates the time t p At time t p +T is the minimum value in brackets.

[0027] Further, in the step S4, performing noise reduction processing on the fifth mass spectrometry detection signal according to the first inherent noise, the second inherent noise and the environmental noise difference information specifically includes:

[0028] The following formula (3) is used to obtain the noise reduction mass spectrometry detection signal corresponding to the fifth mass spectrometry detection signal after the noise reduction processing is performed according to the first inherent noise amplitude, the second inherent noise amplitude, and the environmental noise difference value between the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system.

[0029] G 1 '(t now )=[G 1 (t now )-X(1)]-[G 2 (t now )-X(2)+H] (3)

[0030] In the above formula (3), G 1 '(t now ) represents the digital signal amplitude of the noise reduction mass spectrum detection signal corresponding to the fifth mass spectrum detection signal generated at the current moment after the noise reduction processing is performed; t now Indicates the current moment; G 1 (t now ) represents the digital signal amplitude of the fifth mass spectrometer detection signal generated by the target triple quadrupole mass spectrometer system at the current moment before noise reduction; G 2 (t now ) represents the digital signal amplitude of the spectrum detection signal generated by the reference triple quadrupole mass spectrometer system at the current moment before noise reduction.

[0031] Furthermore, the fifth mass spectrometry detection signal that has undergone noise reduction processing is uploaded to a preset data storage platform, and the historical storage data of the preset data storage platform is overwritten.

[0032] Compared with the prior art, the noise processing method for the triple quadrupole mass spectrometer system first calibrates the power supply voltage of the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system, and obtains the inherent noise of the signal processing circuit boards respectively connected to the two mass spectrometer systems and the environmental noise difference information between the two mass spectrometer systems; then, according to the above inherent noise and environmental noise difference information, the target triple quadrupole mass spectrometer system performs noise reduction processing on the mass spectrometry detection signal of the sample to be tested. The above method additionally sets a reference triple quadrupole mass spectrometer system as a reference benchmark for signal noise reduction processing, which is different from the prior art that amplifies and performs analog-to-digital conversion filtering processing on the mass spectrometry detection signal, and is an accurate reference benchmark for the mass spectrometry detection signal, thereby maximizing the filtering and removal of the inherent noise components and environmental noise components of the mass spectrometry detection signal and improving the detection accuracy and reliability of the mass spectrometer.

[0033] Other features and advantages of the present invention will be described in the following description, and partly become apparent from the description, or understood by practicing the present invention. The purpose and other advantages of the present invention can be realized and obtained by the structures particularly pointed out in the written description, claims, and drawings.

[0034] The technical solution of the present invention is further described in detail below through the accompanying drawings and embodiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0036] Figure 1 A schematic flow chart of a noise processing method for a triple quadrupole mass spectrometer system provided by the present invention. DETAILED DESCRIPTION

[0037] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0038] See also Figure 1 , is a flow chart of a noise processing method for a triple quadrupole mass spectrometer system provided by an embodiment of the present invention. The noise processing method for a triple quadrupole mass spectrometer system comprises the following steps:

[0039] Step S1, placing preset standard samples in a target triple quadrupole mass spectrometer system and a reference triple quadrupole mass spectrometer system for mass spectrometry detection, respectively, and calibrating the power supply voltages of the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system according to first mass spectrometry detection signals and second mass spectrometry detection signals outputted by the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system respectively;

[0040] Step S2, after the power supply voltage calibration is completed, obtaining the first signal and the second signal output by the first signal processing circuit board and the second signal processing circuit board respectively connected to the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system; determining the first inherent noise and the second inherent noise of the first signal processing circuit board and the second signal processing circuit board respectively according to the first signal and the second signal;

[0041] Step S3, after the power supply voltage calibration is completed, obtaining a third mass spectrometry detection signal and a fourth mass spectrometry detection signal outputted by the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system for mass spectrometry detection of a preset standard sample; determining environmental noise difference information between the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system according to the first inherent noise, the second inherent noise, the third mass spectrometry detection signal and the fourth mass spectrometry detection signal;

[0042] Step S4, after the power supply voltage calibration is completed, the sample to be tested is placed in the target triple quadrupole mass spectrometer system for mass spectrometry detection, and a fifth mass spectrometry detection signal correspondingly output by the target triple quadrupole mass spectrometer system is obtained; and the fifth mass spectrometry detection signal is subjected to noise reduction processing according to the first inherent noise, the second inherent noise and the environmental noise difference information.

[0043] The beneficial effects of the above technical scheme are as follows: the noise processing method for the triple quadrupole mass spectrometer system first calibrates the power supply voltage of the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system, and obtains the inherent noise of the signal processing circuit boards respectively connected to the two mass spectrometer systems and the environmental noise difference information between the two mass spectrometer systems; then, according to the above inherent noise and environmental noise difference information, the target triple quadrupole mass spectrometer system performs noise reduction processing on the mass spectrometry detection signal of the sample to be tested. The above method additionally sets a reference triple quadrupole mass spectrometer system as a reference benchmark for signal noise reduction processing, which is different from the prior art that amplifies and performs analog-to-digital conversion filtering processing on the mass spectrometry detection signal. It is an accurate reference benchmark for the mass spectrometry detection signal, thereby maximizing the filtering and removal of the inherent noise components and environmental noise components of the mass spectrometry detection signal and improving the detection accuracy and reliability of the mass spectrometer.

[0044] Preferably, in step S1, the preset standard samples are placed in the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system for mass spectrometry detection, and the power supply voltages of the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system are calibrated according to the first mass spectrometry detection signals and the second mass spectrometry detection signals outputted by the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system, specifically comprising:

[0045] Step S101, placing preset standard samples of the same weight in a target triple quadrupole mass spectrometer system and a reference triple quadrupole mass spectrometer system respectively for mass spectrometry detection, and synchronously inputting the same operating voltage to the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system during the mass spectrometry detection process;

[0046] Step S102, acquiring a first mass spectrometry detection signal and a second mass spectrometry detection signal respectively output by the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system when driven by the same operating voltage;

[0047] Step S103, extracting the peak detection sub-signals contained in the first mass spectrometry detection signal and the second mass spectrometry detection signal; performing signal amplitude comparison between the peak detection sub-signals and the inherent mass spectrometry peak distribution signal of the preset standard sample; and then calibrating the power supply voltages of the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system according to the result of the signal amplitude comparison.

[0048] The beneficial effects of the above technical solution are as follows: in the actual mass spectrometry detection operation, the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system are triple quadrupole mass spectrometer systems of the same model, the target triple quadrupole mass spectrometer system is used to perform mass spectrometry detection on the sample to be tested, and the reference triple quadrupole mass spectrometer system is used to provide a reference for noise filtering processing of the mass spectrometry detection signal output by the target triple quadrupole mass spectrometer system, thereby improving the accuracy of subsequent filtering processing. The corresponding working voltage of the triple quadrupole mass spectrometer system directly affects its working stability during mass spectrometry detection. By comparing the signal amplitude of the peak detection sub-signal contained in the mass spectrometry detection information obtained by performing mass spectrometry detection on the preset standard sample by the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system, it can be determined whether the two triple quadrupole mass spectrometer systems stably excite the preset standard sample, and then the power supply voltage of the triple quadrupole mass spectrometer system is corrected in a targeted manner.

[0049] Preferably, in step S103, calibrating the power supply voltages of the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system according to the result of the signal amplitude comparison specifically includes:

[0050] Obtaining the amplitude difference between the half-peak amplitude of the peak detection sub-signal and the half-peak amplitude of the inherent mass spectrum peak distribution signal;

[0051] According to the amplitude difference, the operating voltage output to the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system is adjusted; when after the operating voltage is adjusted, the re-determined amplitude difference is less than or equal to the preset difference threshold, the adjusted operating voltage is used as the correction power supply voltage for the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system.

[0052] The beneficial effect of the above technical solution is: the half-peak amplitude of the obtained peak detection sub-signal is compared with the known inherent mass spectrum peak distribution signal of the preset standard sample. If the obtained amplitude difference is too small, it is necessary to increase the operating voltage output to the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system. Otherwise, it is necessary to reduce the operating voltage output to the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system until the amplitude difference after adjusting the working voltage is less than or equal to the preset difference threshold. The adjusted working voltage is then used as the final correction power supply voltage, thereby ensuring that the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system can normally excite the sample to be detected under the drive of the correction power supply voltage.

[0053] Preferably, in step S2, after the power supply voltage calibration is completed, obtaining the first signal and the second signal output by the first signal processing circuit board and the second signal processing circuit board respectively connected to the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system specifically comprises:

[0054] Inputting the calibration power supply voltage to the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system, while the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system perform mass spectrometry detection on preset standard samples of the same weight;

[0055] Then, a first signal and a second signal outputted from mass spectrometry detection by a first signal processing circuit board and a second signal processing circuit board connected to the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system respectively are obtained.

[0056] The beneficial effect of the above technical solution is: after the correction power supply voltage is input into the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system, mass spectrometry detection is performed on preset standard samples of the same weight through the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system, so that the first signal and the second signal output by the first signal processing circuit board and the second signal processing circuit board are obtained under the same mass spectrometry detection conditions, avoiding the presence of external interference noise in the first signal and the second signal due to inconsistent mass spectrometry detection conditions.

[0057] Preferably, in the step S2, determining the first inherent noise and the second inherent noise of the first signal processing circuit board and the second signal processing circuit board respectively according to the first signal and the second signal specifically comprises:

[0058] The following formula (1) is used to simulate and reproduce the first inherent noise amplitude or the second inherent noise amplitude corresponding to the first signal processing circuit board or the second signal processing circuit board according to the first signal or the second signal.

[0059]

[0060] In the above formula (1), X represents the first inherent noise amplitude or the second inherent noise amplitude of analog reproduction; D(t) represents the digital noise signal amplitude generated by the first signal processing circuit board or the second signal processing circuit board at time t; t 0 represents the power-on time of the first signal processing circuit board or the second signal processing circuit board; T represents the duration of collecting the first signal or the second signal from the first signal processing circuit board or the second signal processing circuit board; Indicates the time t 0 At time t 0 +T between the mode of the amplitude of the digital noise signal generated by the first signal processing circuit board or the second signal processing circuit board; Indicates the time t 0 At time t 0 +T between the minimum value of the digital noise signal amplitude generated by the first signal processing circuit board or the second signal processing circuit board; Indicates the time t 0 At time t 0 +T is the maximum value of the amplitude of the digital noise signal generated by the first signal processing circuit board or the second signal processing circuit board.

[0061] The beneficial effect of the above technical solution is: using the above formula (1) to simulate the inherent noise amplitude to be offset according to the signal noise generated by the signal processing circuit board, and then conducting a comprehensive overall analysis of the mode, maximum value and minimum value of the noise generated by the circuit board to improve the accuracy of noise reduction and the adaptability of reducing inherent noise.

[0062] Preferably, in step S3, determining the environmental noise difference information between the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system according to the first inherent noise, the second inherent noise, the third mass spectrometer detection signal and the fourth mass spectrometer detection signal specifically includes:

[0063] The environmental noise difference value between the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system is obtained by using the following formula (2) according to the first inherent noise amplitude, the second inherent noise amplitude, the digital signal amplitude of the third mass spectrometer detection signal, and the digital signal amplitude of the fourth mass spectrometer detection signal:

[0064]

[0065] In the above formula (2), H represents the difference in environmental noise between the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system; G 1 (t) represents the digital signal amplitude of the third mass spectrometer detection signal output by the target triple quadrupole mass spectrometer system at time t; G 2 (t) represents the digital signal amplitude of the fourth mass spectrometer detection signal output by the reference triple quadrupole mass spectrometer system at time t; X(1) represents the first inherent noise amplitude; X(2) represents the second inherent noise amplitude; t p represents the common power-on moment of the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system; Indicates the time t p At time t p +The maximum value in brackets between T; Indicates the time t p At time t p +T is the minimum value in brackets.

[0066] The beneficial effect of the above technical solution is: using the above formula (2), according to the first inherent noise amplitude and the second inherent noise amplitude corresponding to the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system, respectively, and the digital signal amplitude of the third mass spectrometer detection signal and the digital signal amplitude of the fourth mass spectrometer detection signal generated by mass spectrometry detection of the preset standard sample, the difference value of the environmental noise between the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system is obtained, so that the environmental noise is eliminated by the comparison method, but because there are differences between the two mass spectrometer systems, the above method maximizes the elimination of the differences between the two instruments, thereby improving the precision and accuracy of noise reduction.

[0067] Preferably, in step S4, performing noise reduction processing on the fifth mass spectrometry detection signal according to the first inherent noise, the second inherent noise and the environmental noise difference information specifically includes:

[0068] The following formula (3) is used to obtain the noise reduction mass spectrometry detection signal corresponding to the fifth mass spectrometry detection signal after the noise reduction processing is performed according to the first inherent noise amplitude, the second inherent noise amplitude, and the environmental noise difference value between the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system.

[0069] G 1 '(t now )=[G 1 (t now )-X(1)]-[G 2 (t now )-X(2)+H] (3)

[0070] In the above formula (3), G 1 '(t now ) represents the digital signal amplitude of the noise reduction mass spectrum detection signal corresponding to the fifth mass spectrum detection signal generated at the current moment after the noise reduction processing is performed; t now Indicates the current moment; G 1 (t now ) represents the digital signal amplitude of the fifth mass spectrometer detection signal generated by the target triple quadrupole mass spectrometer system at the current moment before noise reduction; G 2 (t now ) represents the digital signal amplitude of the spectrum detection signal generated by the reference triple quadrupole mass spectrometer system at the current moment before noise reduction.

[0071] The beneficial effect of the above technical solution is: using the above formula (3) according to the environmental noise difference value between the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system, the first inherent noise amplitude and the second inherent noise amplitude, the fifth mass spectrometer detection signal generated by the target triple quadrupole mass spectrometer system at the current moment is subjected to noise reduction processing, and then the noise reduction processing of the target triple quadrupole mass spectrometer system is completed, the inherent noise and the environmental noise are eliminated to the maximum extent, and an accurate noise reduction result is obtained.

[0072] Preferably, after step S4, the method further comprises:

[0073] The fifth mass spectrometry detection signal that has undergone noise reduction processing is uploaded to a preset data storage platform, and the historical storage data of the preset data storage platform is overwritten.

[0074] The beneficial effect of the above technical solution is: uploading the fifth mass spectrometry detection signal after noise reduction processing to a preset data storage platform, so that the preset data storage platform can record the mass spectrometry detection result data of the target triple quadrupole mass spectrometer system for different samples to be tested, and overwriting the historical storage data of the preset data storage platform can effectively save the data storage space of the preset data storage platform.

[0075] It can be seen from the contents of the above embodiments that the noise processing method for the triple quadrupole mass spectrometer system first calibrates the power supply voltage of the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system, and obtains the inherent noise of the signal processing circuit boards respectively connected to the two mass spectrometer systems and the environmental noise difference information between the two mass spectrometer systems; then, based on the above inherent noise and environmental noise difference information, the target triple quadrupole mass spectrometer system performs noise reduction processing on the mass spectrometry detection signal of the sample to be tested. The above method additionally sets a reference triple quadrupole mass spectrometer system as a reference benchmark for signal noise reduction processing, which is different from the prior art that amplifies and performs analog-to-digital conversion filtering processing on the mass spectrometry detection signal. It is an accurate reference benchmark for the mass spectrometry detection signal, thereby maximizing the filtering and removal of the inherent noise components and environmental noise components of the mass spectrometry detection signal and improving the detection accuracy and reliability of the mass spectrometer.

[0076] Obviously, those skilled in the art can make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include these modifications and variations.

Claims

1. Noise processing method for triple quadrupole mass spectrometer system, It is characterized in that It includes the following steps: Step S1, placing preset standard samples in a target triple quadrupole mass spectrometer system and a reference triple quadrupole mass spectrometer system for mass spectrometry detection, respectively, and calibrating the power supply voltages of the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system according to first mass spectrometry detection signals and second mass spectrometry detection signals outputted by the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system respectively; Step S2, after the power supply voltage calibration is completed, obtaining the first signal and the second signal output by the first signal processing circuit board and the second signal processing circuit board respectively connected to the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system; determining the first inherent noise and the second inherent noise of the first signal processing circuit board and the second signal processing circuit board respectively according to the first signal and the second signal; Step S3, after the power supply voltage calibration is completed, obtaining a third mass spectrometry detection signal and a fourth mass spectrometry detection signal outputted by the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system for mass spectrometry detection of a preset standard sample; determining environmental noise difference information between the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system according to the first inherent noise, the second inherent noise, the third mass spectrometry detection signal and the fourth mass spectrometry detection signal; Step S4, after the power supply voltage calibration is completed, placing the sample to be tested in the target triple quadrupole mass spectrometer system for mass spectrometry detection, and obtaining a fifth mass spectrometry detection signal correspondingly output by the target triple quadrupole mass spectrometer system; performing noise reduction processing on the fifth mass spectrometry detection signal according to the first inherent noise, the second inherent noise and the environmental noise difference information; Wherein, in the step S2, after the power supply voltage calibration is completed, obtaining the first signal and the second signal output by the first signal processing circuit board and the second signal processing circuit board respectively connected to the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system specifically includes: inputting the calibrated power supply voltage to the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system, and at the same time, the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system perform mass spectrometry detection on preset standard samples of the same weight; Then obtaining a first signal and a second signal outputted by a first signal processing circuit board and a second signal processing circuit board connected to the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system respectively regarding mass spectrometry detection; Wherein, in the step S2, determining the first inherent noise and the second inherent noise of the first signal processing circuit board and the second signal processing circuit board respectively according to the first signal and the second signal specifically includes: The following formula (1) is used to simulate and reproduce the first inherent noise amplitude or the second inherent noise amplitude corresponding to the first signal processing circuit board or the second signal processing circuit board according to the first signal or the second signal. In the above formula (1), X represents the first inherent noise amplitude or the second inherent noise amplitude of analog reproduction; D(t) represents the digital noise signal amplitude generated by the first signal processing circuit board or the second signal processing circuit board at time t; t 0 represents the power-on time of the first signal processing circuit board or the second signal processing circuit board; T represents the duration of collecting the first signal or the second signal from the first signal processing circuit board or the second signal processing circuit board; Indicates the time t 0 At time t 0 +T between the mode of the amplitude of the digital noise signal generated by the first signal processing circuit board or the second signal processing circuit board; Indicates the time t 0 At time t 0 +T between the minimum value of the digital noise signal amplitude generated by the first signal processing circuit board or the second signal processing circuit board; Indicates the time t 0 At time t 0 +T between the maximum value of the amplitude of the digital noise signal generated by the first signal processing circuit board or the second signal processing circuit board; Wherein, in the step S3, determining the environmental noise difference information between the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system according to the first inherent noise, the second inherent noise, the third mass spectrometer detection signal and the fourth mass spectrometer detection signal specifically includes: The environmental noise difference value between the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system is obtained by using the following formula (2) according to the first inherent noise amplitude, the second inherent noise amplitude, the digital signal amplitude of the third mass spectrometer detection signal, and the digital signal amplitude of the fourth mass spectrometer detection signal: In the above formula (2), H represents the difference in environmental noise between the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system; G 1 (t) represents the digital signal amplitude of the third mass spectrometer detection signal output by the target triple quadrupole mass spectrometer system at time t; G 2 (t) represents the digital signal amplitude of the fourth mass spectrometer detection signal output by the reference triple quadrupole mass spectrometer system at time t; X(1) represents the first inherent noise amplitude; X(2) represents the second inherent noise amplitude; t p represents the common power-on moment of the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system; Indicates the time t p At time t p +The maximum value in brackets between T; Indicates the time t p At time t p +T minimum value in brackets; Wherein, in the step S4, performing noise reduction processing on the fifth mass spectrometry detection signal according to the first inherent noise, the second inherent noise and the environmental noise difference information specifically includes: The following formula (3) is used to obtain the noise reduction mass spectrometry detection signal corresponding to the fifth mass spectrometry detection signal after the noise reduction processing is performed according to the first inherent noise amplitude, the second inherent noise amplitude, and the environmental noise difference value between the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system. G 1 ′(t now )=[G 1 (t now )-X(1)]-[G 2 (t now )-X(2)+H] (3) In the above formula (3), G 1 ′(t now ) represents the digital signal amplitude of the noise reduction mass spectrum detection signal corresponding to the fifth mass spectrum detection signal generated at the current moment after the noise reduction processing is performed; t now Indicates the current moment; G 1 (t now ) represents the digital signal amplitude of the fifth mass spectrometer detection signal generated by the target triple quadrupole mass spectrometer system at the current moment before noise reduction; G 2 (t now ) represents the digital signal amplitude of the spectrum detection signal generated by the reference triple quadrupole mass spectrometer system at the current moment before noise reduction.

2. The noise processing method for a triple quadrupole mass spectrometer system according to claim 1, Features: In the step S1, the preset standard samples are placed in the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system for mass spectrometry detection, and the power supply voltages of the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system are calibrated according to the first mass spectrometry detection signals and the second mass spectrometry detection signals outputted by the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system, which specifically includes: Step S101, placing preset standard samples of the same weight in a target triple quadrupole mass spectrometer system and a reference triple quadrupole mass spectrometer system respectively for mass spectrometry detection, and synchronously inputting the same operating voltage to the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system during the mass spectrometry detection process; Step S102, acquiring a first mass spectrometry detection signal and a second mass spectrometry detection signal respectively output by the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system when driven by the same operating voltage; Step S103, extracting the peak detection sub-signals contained in the first mass spectrometry detection signal and the second mass spectrometry detection signal; performing signal amplitude comparison between the peak detection sub-signals and the inherent mass spectrometry peak distribution signal of the preset standard sample; and then calibrating the power supply voltages of the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system according to the result of the signal amplitude comparison.

3. The noise processing method for a triple quadrupole mass spectrometer system according to claim 2, Features: In the step S103, according to the result of the signal amplitude comparison, calibrating the power supply voltage of the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system specifically includes: obtaining the amplitude difference between the half-peak amplitude of the peak detection sub-signal and the half-peak amplitude of the inherent mass spectrum peak distribution signal; According to the amplitude difference, the operating voltage output to the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system is adjusted; when after the operating voltage is adjusted, the re-determined amplitude difference is less than or equal to the preset difference threshold, the adjusted operating voltage is used as the correction power supply voltage for the target triple quadrupole mass spectrometer system and the reference triple quadrupole mass spectrometer system.

4. The noise processing method for a triple quadrupole mass spectrometer system according to claim 1, Features: After step S4, the method further includes: The fifth mass spectrometry detection signal that has undergone noise reduction processing is uploaded to a preset data storage platform, and the historical storage data of the preset data storage platform is overwritten.

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