Tumor ablation electrode needle

Abstract

The present invention relates to a tumor ablation electrode needle, comprising: an electrode needle body, a blood flow sensor, a gain amplifier module and a multi-stage filter module. The gain amplifier module, the input end of the gain amplifier module is connected to the blood flow sensor; the multi-stage filter module, the input end of the multi-stage filter module is connected to the output end of the gain amplifier module, and the output end of the multi-stage filter module is connected to the tumor ablation host computer, and is used to transmit the amplified and filtered blood flow data to the tumor ablation host computer, and the tumor ablation host computer is used to generate a pulse voltage according to the amplified and filtered blood flow data, and then control the discharge of the electrode needle body. The present invention collects the patient's physiological state by using the blood flow data, amplifies and filters it, and then uploads it to the tumor ablation host computer, and the tumor ablation host computer can adjust the pulse voltage in real time according to the patient's physiological state, so that the electrode needle will not damage normal tissue.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a tumor ablation electrode needle. Background Art

[0002] Nanosecond pulsed electric fields have gained increasing attention in the biomedical field for their unique "intracellular electroprocessing" effect. The so-called "intracellular electroprocessing" effect refers to a biological effect that is completely different from the microsecond pulse electroporation phenomenon in cells under the action of external nanosecond pulses, that is, there will be no obvious electroporation phenomenon on the cell membrane surface, but a series of functional changes will occur in the cell interior, such as the nucleus and mitochondria, producing a large number of micronuclei, and inducing programmed cell death, also known as "apoptosis". Therefore, in the clinical treatment of tumor diseases, using nanosecond pulsed electric fields of different intensities to penetrate tumor cells can kill tumor cells without damaging normal cells, and has a good therapeutic effect.

[0003] Electrode needles are a type of device that is made based on the "intracellular electrical processing" effect and is used in the treatment of tumor diseases. In the treatment of tumor diseases, the electrode needles need to be inserted into the human body to perform micro-discharge treatment on the lesion and necrosis. The current will break down the cancerous cells to eliminate the cancer cells. The operation is convenient and efficient, and the treatment effect is good. However, during the treatment process, the existing electrode needles cannot adjust the discharge voltage in real time, which makes it easy for doctors to damage normal tissues during operation. Summary of the invention

[0004] In order to solve the above problems, an embodiment of the present invention aims to provide a tumor ablation electrode needle, aiming to solve the problem that the discharge voltage of the existing electrode needle cannot be adjusted in real time during the treatment process.

[0005] A tumor ablation electrode needle, comprising:

[0006] The electrode needle body is connected to the tumor ablation host computer;

[0007] A blood flow sensor, used for collecting blood flow data;

[0008] A gain amplification module, wherein an input end of the gain amplification module is connected to the blood flow sensor;

[0009] A multi-stage filtering module, the input end of the multi-stage filtering module is connected to the output end of the gain amplification module, and the output end of the multi-stage filtering module is connected to the tumor ablation host computer, for transmitting the amplified and filtered blood flow data to the tumor ablation host computer, and the tumor ablation host computer is used to generate a pulse voltage according to the amplified and filtered blood flow data, thereby controlling the discharge of the electrode needle body.

[0010] Preferably, the gain amplification module comprises:

[0011] A sampling circuit, wherein the input end of the sampling circuit is connected to the positive and negative output ends of the blood flow sensor;

[0012] an amplifier circuit, wherein the input end of the amplifier circuit is connected to the output end of the sampling circuit, and the output end of the amplifier circuit is connected to the input end of the multi-stage filtering module.

[0013] Preferably, the sampling circuit comprises:

[0014] A positive electrode terminal connected to the positive output terminal of the blood flow sensor;

[0015] A negative electrode terminal connected to a negative electrode output terminal of the blood flow sensor;

[0016] a first resistor, one end of which is connected to the positive electrode terminal;

[0017] a second resistor, one end of the second resistor being connected to the other end of the first resistor, and the other end of the second resistor being connected to the amplifying circuit;

[0018] a first capacitor, one end of the first capacitor being connected to the positive terminal, and the other end of the first capacitor being grounded;

[0019] a second capacitor, one end of the second capacitor being connected to the negative terminal, and the other end of the second capacitor being grounded;

[0020] a third resistor, one end of which is connected to the negative electrode terminal;

[0021] A fourth resistor, one end of the fourth resistor is connected to the other end of the third resistor, and the other end of the fourth resistor is connected to the amplifier circuit.

[0022] Preferably, the amplifying circuit comprises:

[0023] an instrumentation amplifier, wherein a second terminal of the instrumentation amplifier is connected to the other end of the second resistor, and a third terminal of the instrumentation amplifier is connected to the other end of the fourth resistor;

[0024] An adjustable resistor, one end of the adjustable resistor is connected to the first end of the instrument amplifier, and the other end of the adjustable resistor is connected to the eighth end of the instrument amplifier.

[0025] Preferably, the amplifying circuit further includes:

[0026] A third capacitor, one end of the third capacitor is connected to the seventh end of the instrument amplifier, and the other end of the third capacitor is grounded.

[0027] Preferably, the multi-stage filtering module comprises:

[0028] A filter circuit, wherein an input end of the filter circuit is connected to an input end of the amplifier circuit;

[0029] A filter amplifier circuit, wherein the input end of the filter amplifier circuit is connected to the output end of the filter circuit, and the output end of the filter amplifier circuit is connected to the tumor ablation host computer.

[0030] Preferably, the filtering circuit comprises:

[0031] a sixth resistor, one end of which is connected to the output end of the amplifier circuit;

[0032] a seventh resistor, one end of the seventh resistor being connected to the other end of the sixth resistor;

[0033] a fourth capacitor, wherein a positive electrode of the fourth capacitor is connected to the other end of the seventh resistor, and a negative electrode of the fourth capacitor is grounded;

[0034] a first operational amplifier, wherein a non-inverting input terminal of the first operational amplifier is connected to a positive electrode of the fourth capacitor, and an inverting input terminal of the first operational amplifier is connected to an output terminal of the first operational amplifier;

[0035] A fifth capacitor, wherein a positive electrode of the fifth capacitor is connected to one end of the seventh resistor, and a negative electrode of the fifth capacitor is connected to the output end of the first operational amplifier.

[0036] Preferably, the filtering and amplifying circuit comprises:

[0037] a seventh capacitor, wherein a positive electrode of the seventh capacitor is connected to an output end of the filter circuit;

[0038] a tenth resistor, one end of the tenth resistor being connected to the negative electrode of the seventh capacitor, and the other end of the tenth resistor being grounded;

[0039] a second operational amplifier, wherein a non-inverting input terminal of the second operational amplifier is connected to one end of the tenth resistor;

[0040] an eighth resistor, one end of the eighth resistor being connected to the inverting input terminal of the second operational amplifier, and the other end of the eighth resistor being grounded;

[0041] A ninth resistor, one end of the ninth resistor is connected to one end of the eighth resistor, and the other end of the ninth resistor is connected to the output end of the second operational amplifier.

[0042] Preferably, it also includes:

[0043] An electric needle moving slider is fixedly connected to the electrode needle body;

[0044] An insulating sleeve, sleeved on the electrode needle body;

[0045] A control handle is provided with the electroneedle moving slider, and one end of the control handle is fixedly connected to the insulating sleeve for controlling the telescopic length of the electrode needle body.

[0046] Preferably, a slider slot is provided on the control handle; and the electroacupuncture moving slider is provided on the slider slot.

[0047] According to the specific embodiments provided by the present invention, the present invention discloses the following technical effects:

[0048] The present invention relates to a tumor ablation electrode needle, comprising: an electrode needle body, a blood flow sensor, a gain amplifier module and a multi-stage filter module. The gain amplifier module, the input end of the gain amplifier module is connected to the blood flow sensor; the multi-stage filter module, the input end of the multi-stage filter module is connected to the output end of the gain amplifier module, and the output end of the multi-stage filter module is connected to the tumor ablation host computer, and is used to transmit the amplified and filtered blood flow data to the tumor ablation host computer, and the tumor ablation host computer is used to generate a pulse voltage according to the amplified and filtered blood flow data, and then control the discharge of the electrode needle body. The present invention collects the patient's physiological state by using the blood flow data, amplifies and filters it, and then uploads it to the tumor ablation host computer, and the tumor ablation host computer can adjust the pulse voltage in real time according to the patient's physiological state, so that the electrode needle will not damage normal tissue.

[0049] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, preferred embodiments are given below and described in detail with reference to the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0050] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0051] Figure 1 A schematic diagram of a tumor ablation electrode needle in an embodiment provided by the present invention;

[0052] Figure 2 A circuit diagram of a gain amplification module in an embodiment of the present invention;

[0053] Figure 3 A filter circuit diagram in an embodiment provided by the present invention;

[0054] Figure 4 This is a filter amplifier circuit diagram in an embodiment of the present invention.

[0055] Explanation of symbols:

[0056] 1. Electrode needle body; 2. Insulating sleeve; 3. Control handle; 4. Electroneedle moving slider; 5. Scale; 6. Scale groove; 7. Slider groove; 8. Power indicator light; 9. Data cable. DETAILED DESCRIPTION

[0057] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.

[0058] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0059] In the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be an indirect connection through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0060] The purpose of the embodiment of the present invention is to provide a tumor ablation electrode needle, aiming to solve the problem that the discharge voltage of the existing electrode needle cannot be adjusted in real time during the treatment process.

[0061] See also Figure 1A tumor ablation electrode needle comprises: an electrode needle body 1, an electric needle moving slider 4, an insulating sleeve 2, a control handle 3, a slider slot 7, a blood flow sensor, a gain amplification module and a multi-stage filtering module.

[0062] The electric needle moving slider 4 is fixedly connected to the electrode needle body 1; the insulating sleeve 2 is sleeved on the electrode needle body 1; the electric needle moving slider 4 is provided on the control handle 3, and one end of the control handle 3 is fixedly connected to the insulating sleeve 2 for controlling the telescopic length of the electrode needle body 1.

[0063] Furthermore, a slider slot 7 is provided on the control handle 3; the electroacupuncture moving slider 4 is provided on the slider slot 7. A scale 5 and a scale slot 6 are also provided around the slider slot 7, so that the doctor can adjust the length of the electrode needle body 1 extending out of the insulating sleeve 2. A power indicator light 8 is also provided on the control handle 3 to display the working status of the electrode needle body 1. The gain amplification module and the multi-stage filtering module are both provided in the control handle 3, and are connected to the blood flow sensor and the tumor ablation host computer through a data line 9.

[0064] The electrode needle body is connected to the tumor ablation host computer; the input end of the gain amplifier module is connected to the blood flow sensor; the blood flow sensor is used to collect blood flow data. The input end of the multi-stage filter module is connected to the output end of the gain amplifier module, and the output end of the multi-stage filter module is connected to the tumor ablation host computer, which is used to transmit the amplified and filtered blood flow data to the tumor ablation host computer. The tumor ablation host computer is used to generate a pulse voltage according to the amplified and filtered blood flow data, thereby controlling the discharge of the electrode needle body.

[0065] The present invention collects the patient's physiological state by using blood flow data, amplifies and filters it, and then uploads it to the tumor ablation host computer. The tumor ablation host computer can adjust the pulse voltage in real time according to the patient's physiological state, so that the electrode needle will not damage normal tissue.

[0066] See also Figure 2 Preferably, the gain amplification module comprises:

[0067] The sampling circuit has an input end connected to the positive and negative output ends of the blood flow sensor; the sampling circuit includes: positive and negative electrode terminals, a first resistor R1, a second resistor R2, a first capacitor C1, a second capacitor C2, a third resistor R3 and a fourth resistor R4.

[0068] The positive terminal J1 is connected to the positive output end of the blood flow sensor; the negative terminal J2 is connected to the negative output end of the blood flow sensor; one end of the first resistor R1 is connected to the positive terminal; one end of the second resistor R2 is connected to the other end of the first resistor R1, and the other end of the second resistor R2 is connected to the amplifier circuit; one end of the first capacitor C1 is connected to the positive terminal, and the other end of the first capacitor C1 is grounded; one end of the second capacitor C2 is connected to the negative terminal, and the other end of the second capacitor C2 is grounded; one end of the third resistor R3 is connected to the negative terminal; one end of the fourth resistor R4 is connected to the other end of the third resistor R3, and the other end of the fourth resistor R4 is connected to the amplifier circuit.

[0069] The amplifier circuit has an input end connected to the output end of the sampling circuit, and an output end of the amplifier circuit connected to the input end of the multi-stage filtering module. Preferably, the amplifier circuit includes: an instrument amplifier, an adjustable resistor R5 and a third capacitor C3.

[0070] The second end of the instrument amplifier is connected to the other end of the second resistor R2, and the third end of the instrument amplifier is connected to the other end of the fourth resistor R4; in the present invention, the instrument amplifier model is: INA122. One end of the adjustable resistor R5 is connected to the first end of the instrument amplifier, the other end of the adjustable resistor R5 is connected to the eighth end of the instrument amplifier, one end of the third capacitor C3 is connected to the seventh end of the instrument amplifier, and the other end of the third capacitor C3 is grounded. The present invention adjusts the gain of the amplifier circuit by adjusting the resistance value of the adjustable resistor R5, thereby facilitating the processing of blood flow data.

[0071] Preferably, the multi-stage filtering module includes: a filtering circuit, the input end of the filtering circuit is connected to the input end of the amplifier circuit; a filtering amplifier circuit, the input end of the filtering amplifier circuit is connected to the output end of the filtering circuit, and the output end of the filtering amplifier circuit is connected to the tumor ablation host computer.

[0072] See also Figure 3 Furthermore, the filtering circuit includes: a sixth resistor R6, a seventh resistor R7, a fourth capacitor C4, a first operational amplifier P1 and a fifth capacitor C5.

[0073] One end of the sixth resistor R6 is connected to the output end of the amplifier circuit; one end of the seventh resistor R7 is connected to the other end of the sixth resistor R6; the positive electrode of the fourth capacitor C4 is connected to the other end of the seventh resistor R7, and the negative electrode of the fourth capacitor C4 is grounded; the non-inverting input end of the first operational amplifier P1 is connected to the positive electrode of the fourth capacitor C4, and the inverting input end of the first operational amplifier P1 is connected to the output end of the first operational amplifier P1; the positive electrode of the fifth capacitor C5 is connected to one end of the seventh resistor R7, and the negative electrode of the fifth capacitor C5 is connected to the output end of the first operational amplifier P1.

[0074] See also Figure 4 Furthermore, the filtering and amplifying circuit includes: a seventh capacitor, a tenth resistor R10, a second operational amplifier P2, an eighth resistor R8 and a ninth resistor R9.

[0075] The positive electrode of the seventh capacitor is connected to the output end of the filter circuit; one end of the tenth resistor R10 is connected to the negative electrode of the seventh capacitor, and the other end of the tenth resistor R10 is grounded; the non-inverting input end of the second operational amplifier P2 is connected to one end of the tenth resistor R10; one end of the eighth resistor R8 is connected to the inverting input end of the second operational amplifier P2, and the other end of the eighth resistor R8 is grounded; one end of the ninth resistor R9 is connected to one end of the eighth resistor R8, and the other end of the ninth resistor R9 is connected to the output end of the second operational amplifier P2.

[0076] The present invention processes blood flow data by utilizing a gain amplification module and a multi-stage filtering module, thereby amplifying and filtering weak blood flow signals, improving the acquisition accuracy of blood flow data, and thereby greatly improving the control accuracy of the pulse voltage by the tumor ablation host computer.

[0077] According to the specific embodiments provided by the present invention, the present invention discloses the following technical effects:

[0078] The present invention collects the patient's physiological state by using blood flow data, amplifies and filters it, and then uploads it to the tumor ablation host computer. The pulse voltage can be adjusted in real time according to the patient's physiological state, so that the electrode needle will not damage normal tissue.

[0079] The above is only a specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any technical solution that can be easily thought of by a person skilled in the art within the technical scope disclosed by the present invention should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention shall be based on the protection scope of the claims.

Claims

1. A tumor ablation electrode needle, characterized in that: include: The electrode needle body is connected to the tumor ablation host computer; A blood flow sensor, used for collecting blood flow data; A gain amplification module, wherein an input end of the gain amplification module is connected to the blood flow sensor; A multi-stage filtering module, the input end of the multi-stage filtering module is connected to the output end of the gain amplification module, and the output end of the multi-stage filtering module is connected to the tumor ablation host computer, and is used to transmit the amplified and filtered blood flow data to the tumor ablation host computer, and the tumor ablation host computer is used to generate a pulse voltage according to the amplified and filtered blood flow data, thereby controlling the discharge of the electrode needle body; An electric needle moving slider is fixedly connected to the electrode needle body; An insulating sleeve, sleeved on the electrode needle body; A control handle, on which the electroneedle moving slider is disposed, and one end of the control handle is fixedly connected to the insulating sleeve, and is used to control the telescopic length of the electrode needle body; The gain amplification module comprises: A sampling circuit, wherein the input end of the sampling circuit is connected to the positive and negative output ends of the blood flow sensor; an amplifier circuit, wherein an input end of the amplifier circuit is connected to an output end of the sampling circuit, and an output end of the amplifier circuit is connected to an input end of the multi-stage filtering module; The sampling circuit comprises: A positive electrode terminal connected to the positive output terminal of the blood flow sensor; A negative electrode terminal connected to a negative electrode output terminal of the blood flow sensor; a first resistor, one end of which is connected to the positive electrode terminal; a second resistor, one end of the second resistor being connected to the other end of the first resistor, and the other end of the second resistor being connected to the amplifying circuit; a first capacitor, one end of the first capacitor being connected to the positive terminal, and the other end of the first capacitor being grounded; a second capacitor, one end of the second capacitor being connected to the negative terminal, and the other end of the second capacitor being grounded; a third resistor, one end of which is connected to the negative electrode terminal; a fourth resistor, one end of the fourth resistor being connected to the other end of the third resistor, and the other end of the fourth resistor being connected to the amplifier circuit; The amplifying circuit comprises: an instrumentation amplifier, wherein a second terminal of the instrumentation amplifier is connected to the other end of the second resistor, and a third terminal of the instrumentation amplifier is connected to the other end of the fourth resistor; an adjustable resistor, one end of the adjustable resistor being connected to the first end of the instrument amplifier, and the other end of the adjustable resistor being connected to the eighth end of the instrument amplifier; The amplifying circuit further includes: a third capacitor, one end of the third capacitor being connected to the seventh end of the instrument amplifier, and the other end of the third capacitor being grounded; The multi-stage filtering module comprises: A filter circuit, wherein an input end of the filter circuit is connected to an input end of the amplifier circuit; A filter amplifier circuit, wherein the input end of the filter amplifier circuit is connected to the output end of the filter circuit, and the output end of the filter amplifier circuit is connected to the tumor ablation host computer; The filtering circuit comprises: a sixth resistor, one end of which is connected to the output end of the amplifier circuit; a seventh resistor, one end of the seventh resistor being connected to the other end of the sixth resistor; a fourth capacitor, wherein a positive electrode of the fourth capacitor is connected to the other end of the seventh resistor, and a negative electrode of the fourth capacitor is grounded; a first operational amplifier, wherein a non-inverting input terminal of the first operational amplifier is connected to a positive electrode of the fourth capacitor, and an inverting input terminal of the first operational amplifier is connected to an output terminal of the first operational amplifier; a fifth capacitor, wherein a positive electrode of the fifth capacitor is connected to one end of the seventh resistor, and a negative electrode of the fifth capacitor is connected to an output end of the first operational amplifier; The filtering and amplifying circuit comprises: a seventh capacitor, wherein a positive electrode of the seventh capacitor is connected to an output end of the filter circuit; a tenth resistor, one end of the tenth resistor being connected to the negative electrode of the seventh capacitor, and the other end of the tenth resistor being grounded; a second operational amplifier, wherein a non-inverting input terminal of the second operational amplifier is connected to one end of the tenth resistor; an eighth resistor, one end of the eighth resistor being connected to the inverting input terminal of the second operational amplifier, and the other end of the eighth resistor being grounded; A ninth resistor, one end of the ninth resistor is connected to one end of the eighth resistor, and the other end of the ninth resistor is connected to the output end of the second operational amplifier.

2. A tumor ablation electrode needle according to claim 1, characterized in that: The control handle is provided with a slider slot; the electroacupuncture moving slider is provided on the slider slot.

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