A continuous method for the synthesis of isobutyryl chloride

By carrying out the acyl chloride reaction of isobutyric acid and thionyl chloride in a continuous flow reactor, the problems of long synthesis time and low yield of isobutyryl chloride have been solved, and efficient, safe and environmentally friendly continuous production has been achieved.

CN114956989BActive Publication Date: 2026-07-21SHANGHAI HYBRID CHEM TECH +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANGHAI HYBRID CHEM TECH
Filing Date
2021-02-26
Publication Date
2026-07-21

AI Technical Summary

Technical Problem

Existing isobutyryl chloride synthesis processes suffer from long reaction times, low yields, inability to achieve large-scale continuous production, and problems such as environmental pollution and complex operation.

Method used

In a continuous flow reactor, amide catalysts are used as catalysts to carry out acyl chloride reaction of isobutyric acid and thionyl chloride. The reaction temperature is controlled at 50-160℃, the pressure at 2-15 bar, and the time at 20-300 s. Phosphorus trichloride is avoided. Microreactors, tubular reactors and other equipment are used for continuous production.

Benefits of technology

It achieves significantly shortened reaction time, high conversion rate and selectivity, fewer side reactions, pure products, simple post-processing, environmental friendliness, and suitability for industrial production.

✦ Generated by Eureka AI based on patent content.

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Abstract

The application discloses a continuous synthesis method of isobutyryl chloride. The method comprises the following steps: carrying out an acyl chloride reaction of isobutyric acid and thionyl chloride in a continuous flow reactor under the action of an amide catalyst, wherein the acyl chloride reaction temperature is 50-160 DEG C, the acyl chloride reaction pressure is 2-15 bar, and the acyl chloride reaction time is 20-300 s. The method overcomes the defect of poor mass and heat transfer performance of a kettle reactor, can stably operate the reaction, greatly shortens the reaction time, reduces energy consumption, saves cost, has few operation steps, is simple to operate, and is high in stability; the liquid holding volume in the reactor is small, the generation of hot spots in the exothermic reaction can be effectively avoided, the safety of the process is greatly improved in essence, the conversion rate is high, the selectivity is high, the side reaction is few, the crude product is free of other impurities, the yield is high, the post-treatment is simple, the separation is easy, there is no amplification effect, and there are no problems such as waste water treatment and environmental pollution.
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