A fixing component for synthesizing a chip

Abstract

The present application discloses a fixing assembly for a synthesis chip, comprising a locking member, a movable member, and a fixed member, wherein the movable member is located between the locking member and the fixed member, the movable member and the fixed member are arranged to move relative to each other, the locking member is rotationally connected to the fixed member, and the locking member is used to drive the movable member to move so that the fixing assembly switches between an open state and a locked state; a mounting groove is provided between the movable member and the fixed member, the mounting groove is used to accommodate a synthesis chip, and the extension direction of the mounting groove is parallel to a vertical plane. The present application adopts the combination of the locking member, the movable member, and the fixed member so that the synthesis chip is placed along the vertical plane, which is conducive to improving the rapid and accurate synthesis of the chip, and is also conducive to cleaning the reaction solution and improving the purity of the target product.

Description

Technical Field

[0001] The present application relates to the technical field of biochips, and in particular to a fixing component for synthesizing a chip. Background Art

[0002] Nucleic acid printers are automated instruments designed for synthesizing oligonucleotides with structures similar to DNA or RNA. Currently, one of the major innovative directions in DNA synthesis technology is to increase throughput through semiconductor chips. In such nucleic acid printers that use chips for synthesis, the chip needs to be fixedly installed in the machine, and then the liquid inlet and outlet pipes are connected to the chip so that the raw materials and reagents are immersed in the working surface of the chip to facilitate the electrochemical synthesis reaction. However, in existing nucleic acid printers, the chip is mostly placed horizontally, which is prone to displacement during fixation, resulting in inaccurate chip positioning, thereby affecting the electrochemical synthesis reaction. In addition, the working surface of the chip faces upward, which easily leads to residual reaction liquid during cleaning, resulting in the purity of the target product failing to meet expectations and low product quality.

[0003] Application Contents

[0004] To address the problems in the prior art, the present application provides a fixing assembly for a synthesis chip that can be quickly positioned and fixed with good accuracy, is easy to clean, avoids accumulation of reaction liquid, and improves the purity of the target product. The technical solution is as follows:

[0005] The present application provides a fixing assembly for a synthetic chip, comprising a locking member, a moving member, and a fixing member, wherein the moving member is located between the locking member and the fixing member, the moving member and the fixing member are arranged to move relative to each other, the locking member is rotatably connected to the fixing member, and the locking member is used to drive the moving member to move, so that the fixing assembly can be switched between an open state and a locked state;

[0006] A mounting groove is provided between the movable member and the fixed member. The mounting groove is used to accommodate a synthesis chip. An extending direction of the mounting groove is parallel to a vertical plane.

[0007] Furthermore, the locking member includes at least one rotating arm, one end of the rotating arm is a locking end, the locking end is rotatably connected to the fixed member, and the rotating arm can rotate around the locking end; the locking end is also used to abut against a side of the movable member away from the fixed member.

[0008] Furthermore, the locking end includes a first contact surface and a second contact surface, and a distance between the first contact surface and the rotation axis of the locking end is smaller than a distance between the second contact surface and the rotation axis of the locking end.

[0009] Furthermore, the fixing assembly further includes a plurality of reset members, one end of each reset member is connected to the moving member, and the other end of each reset member is connected to the fixing member.

[0010] Furthermore, at least one elastic positioning portion is provided on the side wall of the installation groove, and the elastic positioning portion is used to position the synthetic chip.

[0011] Furthermore, the mounting slot includes an insertion port and an end, the insertion port is an open structure, and the end is a closed structure; an observation window is provided on the movable member, and the observation window is provided corresponding to the end.

[0012] Furthermore, the angle between the extension direction of the installation groove and the vertical direction is 0 to 90 degrees.

[0013] Furthermore, the extending direction of the mounting groove is parallel to the vertical direction.

[0014] Furthermore, the fixing component is provided with a plurality of injection channels, and the injection channels are used to inject liquid into the working area of ​​the synthesis chip.

[0015] Furthermore, the fixing assembly further comprises a sealing ring, one end of each of the plurality of injection channels is provided corresponding to the sealing ring, and the sealing ring is used to seal the reaction chamber between the synthesis chip and the injection channel.

[0016] The implementation of this application has the following beneficial effects:

[0017] 1. The locking part, movable part and fixed part of the present application cooperate so that the synthesis chip can be placed along the vertical surface when inserted into the installation slot. On the one hand, the synthesis chip is subjected to the action of gravity, which can avoid displacement during the locking process, which is conducive to quickly and accurately fixing the synthesis chip, and the synthesis chip is not easy to fall off and be damaged; on the other hand, placement along the vertical surface can avoid the accumulation of reaction liquid in the working area, which is conducive to improving the cleaning effect of the working area, improving the purity of the target product, and avoiding affecting the normal progress of subsequent electrochemical synthesis reactions.

[0018] 2. The locking member of the present application adopts a cam structure, which cooperates with the reset member and the sealing ring, so that the synthetic chip is firmly fixed and the locking effect is good, which is also beneficial to improving the sealing of the reaction chamber corresponding to the working area; at the same time, the reset member and the sealing ring are elastic, which can greatly reduce the wear of the fixing component itself and between the fixing component and the synthetic chip, thereby improving the durability of the fixing component. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] To more clearly illustrate the technical solution of this application, the following is a brief introduction to the drawings used in the embodiments, wherein identical components are denoted by identical reference numerals. Obviously, the drawings described below are merely some embodiments of this application, and those skilled in the art can derive other drawings based on these drawings without inventive effort.

[0020] Figure 1 A schematic structural diagram of a fixing component for synthesizing a chip provided in this application;

[0021] Figure 2 A schematic diagram of a fixing assembly for synthesizing a chip provided in the present application in an open state;

[0022] Figure 3 A schematic diagram of the fixing assembly for synthesizing a chip provided in the present application in a locked state;

[0023] Figure 4 for Figure 3 A front view of a fixing assembly for synthesizing a chip;

[0024] Figure 5 for Figure 3 A side view of a fixing assembly for synthesizing a chip;

[0025] Figure 6 Schematic diagram of the structure of the rotating arm in this application;

[0026] Figure 7 for Figure 6 A magnified view of the structure of the middle locking end;

[0027] Figure 8 for Figure 2 A top view of a fixed component for synthesizing a chip;

[0028] Figure 9 This is a schematic diagram of the position of the reset member in this application;

[0029] Figure 10 for Figure 3 Back view of the fixed components used to synthesize the chip;

[0030] Figure 11 for Figure 3 A half-section view of a fixing assembly for synthesizing a chip;

[0031] Figure 12 Schematic diagram of the assembly of the mounting slot and the composite chip provided in this application;

[0032] Figure 13 Schematic diagram of the structure of the synthetic chip.

[0033] Among them, the figure marks correspond to: 1-locking part, 11-rotating arm, 110-locking end, 1101-first contact surface, 1102-transition surface, 1103-second contact surface, 111-central axis hole, 12-connecting arm, 13-central axis, 2-moving part, 21-observation window, 3-fixed part, 31-fixed connection part, 32-rotating connection part, 33-injection interface, 34-electrode lead wire, 35-reference electrode, 4-mounting groove, 41-insertion port, 42-elastic positioning part, 43-end, 5-synthetic chip, 51-working surface, 52-working area, 53-electrode connection point, 54-chip positioning part, 55-mounting surface, 6-reset part, 7-positioning part, 8-sealing ring. DETAILED DESCRIPTION

[0034] The following will be combined with the drawings in the embodiments of this application to clearly and completely describe the technical solutions in the embodiments of this application. Obviously, the embodiments described are only part of the embodiments of this application, not all of the embodiments, and therefore should not be understood as limiting this application. Based on the embodiments in this application, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of this application.

[0035] It should be noted that the terms "first", "second", etc. in the specification, claims, and drawings of the present application are used to distinguish similar objects and are not necessarily used to describe a specific order or sequential order. It should be understood that the data used in this way can be interchangeable where appropriate so that the embodiments of the present application can be implemented in a sequence other than the following diagrams or the following descriptions. In addition, the terms "including" and "having" and any variations thereof are intended to cover non-exclusive inclusions, for example, a process, method, system, product, or server comprising a series of steps or units is not necessarily limited to those steps or units clearly listed, but may include other steps or units that are not clearly listed or inherent to these processes, methods, products, or devices.

[0036] Example

[0037] This embodiment provides a fixing component for a synthesis chip, which is used in a nucleic acid printer, such as Figure 1 As shown, the fixing assembly includes a locking member 1, a moving member 2 and a fixing member 3, wherein the moving member 2 is located between the locking member 1 and the fixing member 3, and the moving member 2 can move relative to the fixing member 3, and the locking member 1 and the fixing member 3 are relatively rotated. When the locking member 1 rotates relatively, the moving member 2 is driven to move, so that the fixing assembly switches between the open state and the locked state; a mounting groove 4 is formed between the moving member 2 and the fixing member 3, and the mounting groove 4 is used to accommodate the synthetic chip 5, such as Figure 2As shown, when the fixing assembly is in the open state, the thickness of the mounting groove 4, that is, the thickness of the gap between the moving part 2 and the fixing part 3 at the position of the mounting groove 4, is greater than or equal to the thickness of the synthetic chip 5, so that the synthetic chip 5 can be easily and quickly inserted into the mounting groove 4 or removed from the mounting groove 4; Figure 3 As shown, the fixing assembly switches from the open state to the locked state, and the movable part 2 moves toward the fixed part 3 under the action of the locking part 1, so that the thickness of the mounting groove 4 is reduced, thereby clamping the synthetic chip 5, fixing it firmly and with high reliability.

[0038] It should be noted that the synthesis chip 5 is used to synthesize the target product nucleic acid, which can be DNA or RNA, and has a wide range of applications; optionally, the synthesis chip 5 can synthesize short-chain DNA, and can also perform in situ DNA purification and splicing, thereby synthesizing long-chain DNA, greatly reducing the cost of long-chain DNA synthesis.

[0039] like Figure 12 and Figure 13 As shown, the synthesis chip 5 includes a working surface 51 and a mounting surface 55, wherein the working surface 51 includes a working area 52 for in situ synthesis of nucleic acids, and the electrochemical synthesis reaction of nucleic acids is carried out in the working area 52; and the mounting surface 55 and the working surface 51 are arranged back to back. When the installation is completed, the working surface 51 faces the fixed part 3, and the mounting surface 55 faces the movable part 2.

[0040] Specifically, if Figure 4 As shown, the locking member 1 includes at least one rotating arm 11. Figure 6 As shown, one end of the rotating arm 11 is a locking end 110, which is rotatably connected to the fixed part 3 and rotates around its own rotation axis; the outer surface of the locking end 110 also abuts against a side of the movable part 2 away from the fixed part 3, so when the rotating arm 11 rotates around the locking end 110, it can push the movable part 2 to move, thereby realizing the opening and locking of the movable part 2.

[0041] In an optional embodiment, the locking end 110 is rotatably connected to the fixing member 3 through at least one central shaft 13, and the central shaft 13 is a rotating shaft or a fixed shaft with good rotation flexibility; optionally, the locking end 110 is rotatably connected to the fixing member 3 through a fixed shaft, and the fixed shaft is fixedly connected to the fixing member 3, and the locking end 110 is rotatably connected to the fixed shaft; optionally, the locking end 110 is rotatably sleeved on the fixed shaft, and the rotation axis of the locking end 110 coincides with the central axis of the fixed shaft.

[0042] Optionally, the locking end 110 is rotatably connected to the fixing member 3 via a rotating shaft, the locking end 110 is fixedly connected to the rotating shaft, the rotating shaft is rotatably connected to the fixing member 3, and the rotation axis of the locking end 110 coincides with the central axis of the rotating shaft; optionally, the locking end 110 and the rotating shaft are integrally formed.

[0043] In an optional embodiment, the locking member 1 includes a rotating arm 11, and the locking end 110 is rotatably connected to the fixing member 3 through a central axis 13. By applying force to the other end of the rotating arm 11 away from the locking end 110, the rotating arm 11 rotates around the central axis 13, thereby achieving the locking of the fixing assembly. The structure is simple, the number of parts is small, and the processing cost is low.

[0044] In an optional embodiment, the locking member 1 is provided with two rotating arms 11, both of which are rotatably connected to the fixing member 3, and the rotation axes of the two rotating arms 11 coincide with each other; optionally, the two rotating arms 11 are rotatably connected to the fixing member 3 respectively through the same central shaft 13; also optionally, there are two central shafts 13, each rotating arm 11 is connected to the fixing member 3 through a central shaft 13, and the central axes of the two central shafts 13 coincide with each other.

[0045] Specifically, the locking member 1 further includes a connecting arm 12 , and the other ends of the two rotating arms 11 away from the locking end 110 are connected via the connecting arm 12 , so that the two rotating arms 11 can rotate synchronously with good rotation balance.

[0046] Specifically, if Figure 5 As shown, the fixing member 3 includes a fixed connection portion 31 and two rotating connection portions 32 arranged perpendicular to each other, wherein the fixed connection portion 31 is used to be fixedly connected to the machine housing of the nucleic acid printer, and the rotating connection portion 32 is rotatably connected to the rotating arm 11; one side of the rotating connection portion 32 is fixedly connected to the fixed connection portion 31, and the other side extends in a direction away from the fixed connection portion 31, and the extension length of the rotating connection portion 32 is greater than the thickness of the moving member 2, that is, the connection between the rotating connection portion 32 and the central axis 13 passes over the moving member 2, so that the contact position between the locking member 1 and the moving member 2 is located on the side of the moving member 2 away from the fixed connection portion 31. The locking end 110 can apply pressure to the moving member 2 toward the rotating connection portion 31 during the locking process, which is convenient and labor-saving to use and has a good locking effect.

[0047] Specifically, if Figure 7As shown, a central axis hole 111 is further provided on the locking end 110, and a central axis 13 is passed through the central axis hole 111 to connect the locking end 110 with the rotating connection part 32, and the rotating arm 11 can rotate around the center of the central axis hole 111. Optionally, the central axis of the central axis hole 111 is the rotation axis of the locking end 110; the locking end 110 is a cam structure, which includes a first contact surface 1101, a transition surface 1102 and a second contact surface 1103, wherein the first contact surface 1101 abuts against the moving part 2 when in the open state, and the second contact surface 1103 abuts against the moving part 2 when in the locked state, and the transition surface 1102 abuts against the moving part during the locking process of the fixed component switching from the open state to the locked state.

[0048] like Figure 7 As shown, in this embodiment, the distance between the first contact surface 1101 and the rotation axis of the locking end 110 is smaller than the distance between the second contact surface 1103 and the rotation axis of the locking end 110, that is, the radius of the sphere corresponding to the first contact surface 1101 is smaller than the radius of the sphere corresponding to the second contact surface 1103, and the stroke of the moving part 2 is equal to the difference between the radius of the second contact surface 1103 and the radius of the first contact surface 1101; optionally, the radius here can refer to the distance from the center of the center axis hole 111 to the first contact surface 1101 or the distance from the center of the circle to the second contact surface 1103; the spacing between the first contact surface 1101 and the surface of the fixed connection part 31 in the open state is greater than the spacing between the second contact surface 1103 and the surface of the fixed connection part 31 in the locked state, so that the gap thickness of the mounting groove 4 in the open state is greater than the gap thickness in the locked state, which facilitates the smooth insertion or removal of the synthetic chip 5.

[0049] One end of the transition surface 1102 is connected to the first contact surface 1101, and the other end is connected to the second contact surface 1103. The transition surface 1102 is a gradient structure with a gradually increasing radius, wherein the minimum radius is equal to the radius of the first contact surface 1101, and the maximum radius is equal to the radius of the second contact surface 1103; optionally, the transition surface 1102 is an arc-shaped gradient structure; further, the transition surface 1102 can be optionally an elliptical gradient structure.

[0050] Specifically, if Figure 8 and Figure 9As shown, the fixing assembly also includes a plurality of reset members 6, one end of the reset member 6 is connected to the moving member 2, and the other end is connected to the fixed connection part 31. The compression amount of the reset member 6 in the locked state is greater than the compression amount in the open state, and the deformation amount of the reset member 6 during the compression or opening process is equal to the difference between the radius of the second contact surface 1103 and the radius of the first contact surface 1101; during the opening process of the moving member 2, the reset member 6 applies a pressure perpendicular to the fixed connection part 31 and in a direction away from the fixed connection part 31 to the moving member 2, so that the moving member 2 opens to the maximum distance in the open state, making it more convenient to place the synthetic chip 5; optionally, the reset member 6 is a spring, which is easy to install and has low cost.

[0051] like Figure 9 As shown, in an optional embodiment, the fixing assembly is further provided with a positioning member 7, one end of the positioning member 7 is inserted in the movable member 2, and the other end is inserted in the fixed connection portion 31, which can effectively limit the relative position between the movable member 2 and the fixed member 3, and avoid misalignment between the two as much as possible, thereby avoiding affecting the normal progress of the electrochemical synthesis reaction on the synthesis chip 5; the reset member 6 is sleeved on the positioning member 7, which is conducive to positioning the reset member 6, so that the reset member 6 can be extended and retracted along the axial direction of the positioning member 7, which plays a role in protecting the reset member 6 to a certain extent and prolonging its service life.

[0052] Specifically, if Figure 12 As shown, the mounting slot 4 includes an insertion port 41 and an end 43. The insertion port 41 is an open structure. The synthesis chip 5 is inserted into the mounting slot 4 along the direction from the insertion port 41 to the end 43. Figure 2 The direction indicated by the middle arrow is the insertion direction of the synthetic chip 5, that is, the insertion direction is from the insertion port 41 to the end 43; wherein, the insertion port 41 is a gradual structure, and the width of the mounting groove 4 at the insertion port 41 gradually decreases along the insertion direction, and the width of the end of the insertion port 41 away from the end 43 is greater than the width of the synthetic chip 5, and the width of the end of the insertion port 41 close to the end 43 is equal to the width of the synthetic chip 5, that is, the width of the end of the insertion port 41 away from the end 43 is greater than the width of the end of the insertion port 41 close to the end 43, so that the synthetic chip 5 can be more conveniently and smoothly inserted into the mounting groove 4; the end 43 is a closed structure, and the synthetic chip 5 is abutted against the end 43 when the installation is completed to prevent the synthetic chip 5 from detaching from the mounting groove 4 from the end 43 and causing damage.

[0053] Specifically, the extension direction of the mounting groove 4 is parallel to the vertical plane, and the extension direction is along the insertion port 41 to the end 43, that is, the extension direction of the mounting groove 4 is consistent with the insertion direction of the synthesis chip 5. After the installation is completed, the synthesis chip 5 is placed parallel to the vertical plane (the working surface 51 and the mounting surface 55 are both parallel to the vertical plane); optionally, the acute angle formed between the insertion direction of the synthesis chip 5 and the vertical direction is 0 to 90°. On the one hand, the synthesis chip 5 is subjected to the action of gravity, which makes it easier to insert into the mounting groove 4 and facilitates positioning. Moreover, during the locking process, the synthesis chip 5 is subjected to the action of gravity, and it is not easy for the synthesis chip 5 to retreat to the insertion port 41, which further improves the positioning accuracy and is beneficial to the electrochemical synthesis reaction. On the other hand, after an electrochemical synthesis reaction is completed, the working area 52 on the synthesis chip 5 will be cleaned. In the synthesis chip 5 placed along the vertical plane, the surface of the working area 52 is also parallel to the vertical plane, so that the reaction liquid after the reaction is also flowed down by gravity, as far away as possible from the position of the target product in the working area 52, especially away from the position corresponding to the working electrode in the working area 52, thereby greatly reducing the adhesion and accumulation of residual reaction liquid in the working area 52, improving the purity of the target product, and more effective cleaning can be achieved with fewer cleaning times and less dosage of cleaning agent, greatly improving the cleaning efficiency and cleaning effect.

[0054] Optionally, the acute angle formed between the insertion direction of the synthetic chip 5 and the vertical direction is 0 to 60°; optionally, the acute angle formed between the insertion direction of the synthetic chip 5 and the vertical direction is 0 to 45°; in this embodiment, the insertion direction of the synthetic chip 5 is parallel to the vertical direction, which improves the convenience of insertion and further reduces the tendency of the synthetic chip 5 to retreat during the locking process, making the synthetic chip 5 safer to use.

[0055] Specifically, if Figure 12 As shown, the mounting groove 4 further includes at least one elastic positioning portion 42, the elastic positioning portion 42 is fixedly connected to the side wall of the mounting groove 4, and the elastic positioning portion 42 further includes a protrusion structure, which is used to position the synthesis chip 5; Figure 13As shown, a chip positioning portion 54 is provided on the synthetic chip 5, and the chip positioning portion 54 is provided in a one-to-one correspondence with the elastic positioning portion 42, and the chip positioning portion 54 matches the shape of the raised structure; the synthetic chip 5 is inserted into the mounting groove 4, and the elastic positioning portion 42 is pushed by the side wall of the synthetic chip 5, and deforms in the direction away from the synthetic chip 5 until the chip positioning portion 54 reaches the position where the elastic positioning portion 42 is located, and the chip positioning portion 54 matches the elastic positioning portion 42, and the elastic positioning portion 42 is no longer subjected to force and rebounds, clamping the chip positioning portion 54. At this time, the synthetic chip 5 contacts the end 43 of the mounting groove 4, the position of the synthetic chip 5 is uniquely determined, and the positioning effect is good; in an optional embodiment, the elastic positioning portion 42 is an elastic snap buckle, and the chip positioning portion 54 is a positioning groove. The elastic snap buckle matches the positioning groove, and the snap connection is convenient and the positioning is reliable.

[0056] Specifically, if Figure 1 and Figure 12 As shown, an observation window 21 is provided on the moving part 2 , and the observation window 21 is provided corresponding to the end 43 of the installation groove 4 , so that the operator can observe whether the synthesis chip 5 is installed in place.

[0057] Specifically, if Figure 10 and Figure 11 As shown, a plurality of injection channels are provided in the fixed connection portion 31 for delivering raw material reagents to the working area 52 of the synthesis chip 5 or outputting reaction waste liquid, so as to facilitate in-situ synthesis of nucleic acids in the working area 52 .

[0058] Specifically, if Figure 11 As shown, the fixed assembly also includes a sealing ring 8, which is arranged corresponding to one end of the multiple injection channels. The sealing ring 8 is also arranged corresponding to the working area 52. The injection area of ​​the fixed connection part 31, the working area 52 and the sealing ring 8 surround a sealed reaction chamber; the injection channels are connected to the reaction chamber, and the raw material reagents undergo electrochemical synthesis reactions in the reaction chamber, and nucleic acids are synthesized in situ on the surface of the working area 52. The sealing ring 8 is used to seal the reaction chamber, isolate the reaction chamber from the external environment, and avoid external contamination during the electrochemical synthesis process.

[0059] like Figure 11As shown, one end of the injection channel is an injection interface 33, which is connected to the raw material reagent or waste liquid collection device through a pipeline; when the fixing assembly is fixed to the housing of the nucleic acid printer, the injection interface 33 is inside the housing of the nucleic acid printer, which can avoid the exposure of the pipeline, extend the service life of the pipeline, and help avoid reagent contamination and various adverse reactions caused by pipeline leakage; in this embodiment, two injection channels are provided, one is a liquid inlet channel and the other is a liquid outlet channel. The injection interface 33 of the liquid inlet channel is connected to the raw material reagent through a pipeline, and the other end of the liquid inlet channel is connected to the reaction chamber, so that the raw material reagent can flow from the liquid inlet channel into the reaction chamber through the pipeline; the injection interface 33 of the liquid outlet channel is connected to the waste liquid collection device, and the other end of the liquid outlet channel is connected to the reaction chamber, so that the waste liquid generated by the electrochemical synthesis reaction can flow out from the liquid outlet channel to the waste liquid collection device, thereby avoiding affecting the normal progress of the next electrochemical synthesis reaction.

[0060] Specifically, the synthesis chip 5 is used to perform electrochemical synthesis reactions, and its electrode structure includes a working electrode and a counter electrode, which together constitute a dual-electrode structure. When the electrode structure is connected to a power source, a stable voltage can be formed, so that the raw material reagents undergo an electrochemical synthesis reaction under the action of the voltage; in this embodiment, the sampling area includes a plurality of electrode lead wires 34, and a plurality of electrode connection points 53 are arranged on the working surface 51 of the synthesis chip 5. The electrode lead wires 34 are arranged corresponding to the electrode connection points 53 and are used to be connected to an external power source, thereby generating a voltage on the working electrode of the synthesis chip 5 to synthesize one or more target products, and the synthesis flux is high.

[0061] Specifically, if Figure 11 As shown, the sampling area also includes a reference electrode 35, which is located on the side of the sampling area facing the working area 52. The reference electrode 35 is also located in the hollow structure in the middle of the sealing ring 8, and can form a three-electrode structure together with the working electrode and the counter electrode in the synthesis chip 5, which has higher stability; optionally, the reference electrode 35 is a platinum sheet with excellent conductive properties.

[0062] In this embodiment, the sealing ring 8 is in a compressed state in the locked state, one side is sealed with the injection area, and the other side is sealed with the working surface 51 of the synthesis chip 5. When switching from the open state to the locked state, the compression amount of the sealing ring 8 is equal to the difference between the curvature radius of the second contact surface 1103 and the first contact surface 1101, and the sealing performance is good; in an optional embodiment, the sealing ring 8 is an elastic sealing ring, which can be made of rubber or elastic plastic material.

[0063] It can be seen from the above embodiments that the present application has the following beneficial effects:

[0064] 1. The locking part, movable part and fixed part of the present application cooperate so that the synthesis chip can be placed along the vertical surface when inserted into the installation slot. On the one hand, the synthesis chip is subjected to the action of gravity, which can avoid displacement during the locking process, which is conducive to quickly and accurately fixing the synthesis chip, and the synthesis chip is not easy to fall off and be damaged; on the other hand, placement along the vertical surface can avoid the accumulation of reaction liquid in the working area, which is conducive to improving the cleaning effect of the working area, improving the purity of the target product, and avoiding affecting the normal progress of subsequent electrochemical synthesis reactions.

[0065] 2. The locking member of the present application adopts a cam structure, which cooperates with the reset member and the sealing ring, so that the synthetic chip is firmly fixed and the locking effect is good, which is also beneficial to improving the sealing of the reaction chamber corresponding to the working area; at the same time, the reset member and the sealing ring are elastic, which can greatly reduce the wear of the fixing component itself and between the fixing component and the synthetic chip, thereby improving the durability of the fixing component.

[0066] What is described above are only some embodiments of the present application and are not intended to limit the present application. Those skilled in the art should understand that the present application may be subject to various changes and improvements, and any modifications, equivalent substitutions, and improvements made in accordance with the present application shall fall within the scope of protection required by the present application.

Claims

1. A fixing assembly for a synthetic chip, characterized in that: The invention comprises a locking member (1), a moving member (2) and a fixing member (3), wherein the moving member (2) is located between the locking member (1) and the fixing member (3), the moving member (2) and the fixing member (3) are arranged to move relative to each other, the locking member (1) and the fixing member (3) are rotatably connected, and the locking member (1) is used to drive the moving member (2) to move, so that the fixing assembly can be switched between an open state and a locked state; The fixing member (3) comprises a fixed connection portion (31) and two rotating connection portions (32) arranged perpendicular to each other, wherein one side of the rotating connection portion (32) is fixedly connected to the fixed connection portion (31) and the other side extends in a direction away from the fixed connection portion (31); The locking member (1) comprises at least one rotating arm (11), one end of the rotating arm (11) being a locking end (110), the locking end (110) being rotatably connected to the rotating connection portion (32), and the rotating arm (11) being capable of rotating around the locking end (110); The locking end (110) comprises a first contact surface (1101) and a second contact surface (1103), wherein the distance between the first contact surface (1101) and the rotation axis of the locking end (110) is smaller than the distance between the second contact surface (1103) and the rotation axis of the locking end (110), and the locking end (110) is further used to abut against a surface of the movable member (2) away from the fixed member (3); A mounting groove (4) is provided between the movable member (2) and the fixed member (3), the mounting groove (4) being used to accommodate a synthesis chip (5), and an extending direction of the mounting groove (4) being parallel to a vertical plane.

2. The fixing assembly according to claim 1, wherein: The fixing assembly further comprises a plurality of reset members (6), one end of each reset member (6) is connected to the moving member (2), and the other end of each reset member (6) is connected to the fixing member (3).

3. The fixing assembly according to claim 1, wherein: At least one elastic positioning portion (42) is further provided on the side wall of the installation groove (4), and the elastic positioning portion (42) is used to position the synthetic chip (5).

4. The fixing assembly according to claim 1, wherein: The mounting slot (4) comprises an insertion port (41) and an end (43), wherein the insertion port (41) is an open structure and the end (43) is a closed structure; an observation window (21) is provided on the movable member (2), and the observation window (21) and the end (43) are arranged correspondingly.

5. The fixing assembly according to claim 1, wherein: The included angle between the extension direction of the installation groove (4) and the vertical direction is 0-90°.

6. The fixing assembly according to claim 5, characterized in that The extending direction of the installation groove (4) is parallel to the vertical direction.

7. The fixing assembly according to claim 1, wherein: A plurality of injection channels are provided on the fixing member (3), and the injection channels are used to inject liquid into the working area (52) of the synthesis chip (5).

8. The fixing assembly according to claim 7, wherein: The fixing assembly further comprises a sealing ring (8), one end of each of the plurality of injection channels is arranged corresponding to the sealing ring (8), and the sealing ring (8) is used to seal the reaction chamber between the synthesis chip (5) and the injection channel.

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