Blood purification equipment and storage media

Abstract

The present application discloses a blood purification device and a storage medium, the device including a memory and a processor, the memory being used to store a computer program; the processor being used to execute the computer program and, when executing the computer program, implementing the following heparin control method: detecting the blood flow in the arterial line; if the blood flow is less than a first preset flow, controlling the blood purification device to issue a prompt message to prompt the user to perform heparin anticoagulation; if a heparin adjustment operation input by the user in response to the prompt message is detected, causing the heparin pump to control the heparin output line to output heparin to the arterial line according to a recommended flow rate value, the recommended flow rate value being obtained based on the blood flow in the arterial line. In this way, the present application can ensure that the heparin output line outputs heparin to the arterial line in a timely and reasonable manner.

Description

Technical Field

[0001] The present application relates to the technical field of blood purification, and in particular to a blood purification device and a storage medium. Background Art

[0002] When using blood purification equipment for blood purification treatment, an anticoagulant must be used to treat the blood. Currently, heparin is the most commonly used anticoagulant. Adding heparin to the blood during extracorporeal circulation therapy prevents blood from clotting within the circuit, achieving a good anticoagulant effect.

[0003] However, heparin anticoagulation also has certain side effects. Currently, the heparin anticoagulation process in blood purification equipment relies on subjective manual settings. If the heparin anticoagulation rate is set too high, the patient may experience active bleeding or bleeding tendency, especially in patients who have just undergone surgery; if the heparin anticoagulation rate is set too low, the heparin anticoagulation effect cannot be achieved. Therefore, traditional technology relies on subjective manual settings of the heparin anticoagulation rate, making it difficult to set the heparin anticoagulation rate in blood purification equipment to a reasonable value, reducing the heparin anticoagulation effect. Summary of the Invention

[0004] Based on this, the present application provides a blood purification device and storage medium, which can ensure that the heparin output pipeline outputs heparin to the arterial pipeline in a timely and reasonable manner.

[0005] In a first aspect, the present application provides a blood purification device, comprising a display screen, an arterial line, a blood purifier, a venous line, a heparin pump, and a heparin output line; the arterial line is connected to a blood input end of the blood purifier, the venous line is connected to a blood output end of the blood purifier, and the heparin output line is connected between the heparin pump and the arterial line. The blood purification device further comprises: a memory and a processor, the memory being configured to store a computer program; the processor being configured to execute the computer program and, when executing the computer program, implement the following heparin control method for the blood purification device:

[0006] detecting the blood flow in the arterial line;

[0007] If the blood flow rate is less than a first preset flow rate, controlling the blood purification device to issue a prompt message to prompt the user to perform heparin anticoagulation;

[0008] If a heparin adjustment operation input by the user in response to the prompt information is detected, the heparin pump controls the heparin output pipeline to output heparin to the arterial pipeline according to a recommended flow rate value, where the recommended flow rate value is obtained based on the blood flow in the arterial pipeline.

[0009] In a second aspect, the present application provides a computer-readable storage medium storing a computer program, which, when executed by a processor, enables the processor to implement the heparin control method of the blood purification device as described above.

[0010] An embodiment of the present application provides a blood purification device and a storage medium, which detect the blood flow in an arterial line; if the blood flow is less than a first preset flow, the blood purification device is controlled to issue a prompt message to prompt the user to adjust the flow rate of heparin; if a heparin adjustment operation input by the user in response to the prompt message is detected, the heparin pump controls the heparin output line to output heparin to the arterial line according to a recommended flow rate value, where the recommended flow rate value is obtained based on the blood flow in the arterial line. Since the user can only start the heparin pump when it is detected that the blood flow is less than the first preset flow, so that the heparin output pipeline outputs heparin to the arterial pipeline to play a role in blood anticoagulation; the embodiment of the present application sets a reasonable heparin output condition according to the blood flow, and the heparin output pipeline can output heparin to the arterial pipeline in a timely and reasonable manner, which can not only avoid the waste of heparin during the output process and prevent interference with the patient's blood purification process; but also enable the heparin output by the heparin output pipeline to have a good blood anticoagulation effect; therefore, the embodiment of the present application can improve the safety and scope of application of heparin output control of blood purification equipment by setting scientific standards for heparin output.

[0011] It should be understood that the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Figure 1 This is a structural diagram of an embodiment of the blood purification device of the present application;

[0013] Figure 2 This is a schematic diagram of the principle of blood purification treatment of the blood purification device of the present application;

[0014] Figure 3 This is a flow chart of an embodiment of a heparin control method for a blood purification device of the present application;

[0015] Figure 4 This is a schematic diagram of information display on a display screen in the heparin control method of the blood purification device of the present application;

[0016] Figure 5 This is a schematic diagram of a relationship curve between a recommended flow rate of a heparin output line and blood flow in an arterial line in a heparin control method for a blood purification device of the present application;

[0017] Figure 6This is a schematic diagram of a curve showing a change over time of the ratio of the heparin flow rate in the heparin output line to the blood flow rate in the arterial line in the heparin control method of the blood purification device of the present application;

[0018] Figure 7 It is a structural schematic diagram of another embodiment of the blood purification device of the present application. DETAILED DESCRIPTION

[0019] The following will be combined with the drawings in the embodiments of this application to clearly and completely describe the technical solutions in the embodiments of this application. Obviously, the embodiments described are part of the embodiments of this application, not all of them. Based on the embodiments in this application, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of this application.

[0020] The flowcharts shown in the accompanying drawings are for illustrative purposes only and do not necessarily include all contents and operations / steps, nor must they be executed in the order described. For example, some operations / steps may be decomposed, combined, or partially merged, so the actual execution order may vary depending on the actual situation.

[0021] Before describing the embodiments of the present application in detail, the relevant technical contents are first introduced.

[0022] Continuous Renal Replacement Therapy (CRRT) is a general term for all treatments that continuously and slowly remove water and solutes. It is a blood purification technology that supports the function of human organs. With the continuous advancement of clinical application, CRRT technology is no longer limited to the treatment of acute and chronic renal failure. It has gradually expanded to the rescue and treatment of patients with acute and critical conditions such as multiple organ dysfunction syndrome, systemic inflammatory response syndrome, fulminant liver failure, and severe hemorrhagic necrotizing pancreatitis. CRRT technology has achieved excellent clinical treatment results and has been unanimously recognized by experts at home and abroad.

[0023] Figure 1The structure of the blood purification device is shown. When using CRRT technology to treat patients, it is necessary to control the operation of the blood purification device. By controlling the blood purification device to extract the human body's blood from the body, in the process of extracorporeal circulation treatment of the human body's blood, the blood outside the body comes into contact with the chemical materials (such as dialysis membranes) in the pipelines and blood purifiers, which can trigger the body's coagulation mechanism, thereby causing blood clots to form in the pipelines and blood purifiers. Therefore, when using the blood purification device for blood purification treatment, the blood purification treatment process must use anticoagulants to anticoagulant the blood to prevent the formation of blood clots in the pipelines and blood purifiers, forcing the termination of treatment. The commonly used anticoagulant at present is heparin. Heparin is added to the blood in extracorporeal circulation treatment to prevent the blood in the pipeline from clotting, so as to achieve a good anticoagulant effect. However, the heparin anticoagulant method also has certain side effects. The heparin anticoagulation process in current blood purification equipment relies on subjective manual settings. If the heparin anticoagulation rate is set too high during blood purification treatment, it can cause active bleeding or bleeding tendencies, especially in patients who have just undergone surgery. If the heparin anticoagulation rate is set too low during blood purification treatment, the heparin anticoagulation effect cannot be achieved and the body's coagulation mechanism cannot be inhibited. Therefore, traditional technology must rely on subjective manual settings of the heparin anticoagulation rate, making it difficult to set the heparin anticoagulation rate in blood purification equipment to a reasonable value, reducing the heparin anticoagulation effect.

[0024] In the embodiment of the present application, the user can only start the heparin pump when it is detected that the blood flow rate is less than the first preset flow rate, so that the heparin output pipeline outputs heparin to the arterial pipeline to achieve the effect of blood anticoagulation; the embodiment of the present application sets a reasonable heparin output condition according to the blood flow rate, and the heparin output pipeline can output heparin to the arterial pipeline in a timely and reasonable manner, which can not only avoid the waste of heparin during the output process and prevent interference with the patient's blood purification process; but also enable the heparin output by the heparin output pipeline to initiate a good blood anticoagulation effect; therefore, the embodiment of the present application can improve the safety and scope of application of heparin output control of blood purification equipment by setting a scientific standard for heparin output.

[0025] See also Figure 2 and Figure 3 , Figure 2 Shows the principle of blood purification treatment. Figure 3 This is a flow chart of an embodiment of a heparin control method for a blood purification device of the present application.

[0026] Please combine Figure 1 and Figure 2The blood purification device includes a display screen, an arterial line, a blood purifier, a venous line, a heparin pump, and a heparin output line; the arterial line is connected to the blood input end of the blood purifier, the venous line is connected to the blood output end of the blood purifier, and the heparin output line is connected between the heparin pump and the arterial line. The first end of the arterial line is used to connect to the human artery, and the second end of the arterial line is connected to the blood input end of the blood purifier. The first end of the venous line is used to connect to the human vein, and the second end of the venous line is connected to the blood output end of the blood purifier; the arterial line leads the human blood to the blood purifier, and after the blood purifier purifies the human blood, the venous line returns the purified blood to the human body to complete the blood purification process; wherein chemical materials exist inside the blood purifier. When different chemical materials exist inside the blood purifier, the blood purification device can realize different blood purification modes, such as: blood filtration mode, hemodialysis mode, plasma exchange mode, etc.

[0027] The method includes: step S101, step S102 and step S103.

[0028] Step S101: Detecting the blood flow in the arterial line.

[0029] Specifically, when the blood purification device is started to perform blood purification treatment on the patient's blood, the blood flow in the arterial line can be detected by ultrasound, and the blood flow state can be determined based on the blood flow in the arterial line.

[0030] Step S102: If the blood flow rate is less than a first preset flow rate, the blood purification device is controlled to issue a prompt message to prompt the user to perform heparin anticoagulation.

[0031] Specifically, after clinical trials, it was found that the smaller the blood flow in the arterial line, the longer the blood stays in the line and the blood purifier, and the blood outside the body and the chemical materials in the line and the blood purifier are more likely to trigger the coagulation mechanism; after many clinical experiments, when the blood flow in the arterial line is greater than or equal to the first preset flow, the blood flow in the arterial line is relatively large. In this case, the probability of blood coagulation in the line and the blood purifier is very low, and there is no need to use heparin anticoagulation; when the blood flow in the arterial line is less than the first preset flow, the blood flow in the arterial line is small. In this case, the probability of blood coagulation in the line and the blood purifier is high, and heparin anticoagulation is required; therefore, the embodiment of the present application uses the first preset flow to distinguish under what circumstances the blood purification equipment needs heparin anticoagulation.

[0032] When the blood flow rate is greater than or equal to the first preset flow rate, the blood purification device is controlled not to issue a prompt message, and the blood purification device does not need to perform heparin anticoagulation.

[0033] Step S103: If a heparin adjustment operation input by the user in response to the prompt information is detected, the heparin pump controls the heparin output pipeline to output heparin to the arterial pipeline according to a recommended flow rate value, where the recommended flow rate value is obtained based on the blood flow in the arterial pipeline.

[0034] When the user inputs the heparin adjustment operation in response to the prompt information, it means that the user needs to control the blood purification equipment to perform heparin anticoagulation; the blood purification equipment generates a heparin adjustment instruction after detecting the heparin adjustment operation, the heparin pump is started according to the heparin start instruction, and the heparin output pipeline outputs heparin to the arterial pipeline according to the recommended flow rate value. When the arterial pipeline is connected to heparin, the heparin anticoagulation effect can be achieved.

[0035] The recommended flow rate value in the embodiment of the present application is obtained based on the blood flow in the arterial line.

[0036] Specifically, such as Figure 4 As shown, a corresponding relationship between the blood flow in the arterial line and the recommended flow rate of the heparin output line can be established, wherein the corresponding relationship can be obtained by Figure 5 The curve in is represented by Figure 5 As shown in the figure, the recommended flow rate of the heparin output line is negatively correlated with the blood flow in the arterial line. That is, the smaller the blood flow in the arterial line, the larger the recommended flow rate of the heparin output line. This means that more heparin is needed in the line to achieve the anticoagulant effect. Therefore, after obtaining the blood flow in the arterial line, the recommended flow rate of the heparin output line can be calculated according to the blood flow in the arterial line. Figure 5 The recommended flow rate for the heparin output line can be directly obtained from the curve in Figure 5 The curve in can be obtained based on clinical trial data.

[0037] The embodiment of the present application can directly determine the recommended flow rate of the heparin output pipeline based on the blood flow in the arterial pipeline. The recommended flow rate of the heparin output pipeline is kept matched with the blood flow in the arterial pipeline. The amount of heparin output through the heparin output pipeline can just meet the blood anticoagulation demand in the arterial pipeline. When the anticoagulation control process of the blood purification equipment is started, there is no need to manually set the blood flow in the arterial pipeline, thereby improving the heparin anticoagulation safety and heparin anticoagulation efficiency of the blood purification equipment.

[0038] It should be noted that the heparin pump mentioned in this article is a structure that is commonly used in this field, and its structure and working principle will not be described in detail here.

[0039] In one embodiment, issuing the prompt message is achieved by displaying a heparin adjustment button on the display screen. That is, step S102, if the blood flow rate is less than a first preset flow rate, controlling the blood purification device to issue the prompt message, may include: if the blood flow rate is less than the first preset flow rate, controlling the display screen to display the heparin adjustment button.

[0040] At this time, step S103, if it is detected that the user inputs a heparin adjustment operation in response to the prompt information, the heparin pump controls the heparin output pipeline to output heparin to the arterial pipeline according to the recommended flow rate value, which may include: if it is detected that the user triggers the heparin adjustment button, the heparin pump controls the heparin output pipeline to output heparin to the arterial pipeline according to the recommended flow rate value.

[0041] For example, the first preset flow rate is 100 ml / min. When the blood flow rate is detected to be less than the first preset flow rate, the display screen displays a heparin adjustment button, such as Figure 4 As shown, the user triggers the heparin adjustment button to start the heparin anticoagulation step of the blood purification device. When it is detected that the blood flow rate is greater than or equal to the first preset flow rate, the display screen can be controlled to hide the heparin adjustment button.

[0042] In one embodiment, the method further includes: step S104 and step S105.

[0043] Step S104: controlling the display screen to display a flow adjustment button.

[0044] Step S105: If it is detected that the user triggers the flow adjustment button, the heparin pump controls the heparin output pipeline to increase or decrease the heparin flow in the heparin output pipeline according to the heparin adjustment gear, and the heparin adjustment gear is obtained according to the blood flow in the arterial pipeline.

[0045] Specifically, there is a one-to-one correspondence between the blood flow in the arterial line and the heparin adjustment gear, wherein the heparin adjustment gear represents the change range of the heparin flow rate. For example, if the change range of each heparin flow rate is 5ml / h, then the heparin flow rate in the heparin output line will change by 5ml / h. Figure 4The flow adjustment buttons displayed on the display screen include: a flow rate increase button and a flow rate decrease button. When the user triggers the flow rate increase button on the display screen, the heparin pump will control the heparin flow in the heparin output pipeline to increase by 5ml / h. For example, if the heparin flow in the heparin output pipeline is originally 50ml / h, then after the user triggers the flow rate increase button, the heparin flow in the heparin output pipeline is increased to 55ml / h; if the user triggers the flow rate increase button again, the heparin flow in the heparin output pipeline is increased to 60ml / h; and so on. For another example, if the heparin flow in the heparin output pipeline is originally 50ml / h, then after the user triggers the flow rate decrease button, the heparin flow in the heparin output pipeline is decreased to 45ml / h. Therefore, in the embodiment of the present application, the heparin flow in the heparin output pipeline will change according to the heparin adjustment gear, thereby improving the regulation efficiency and regulation safety of the heparin flow in the heparin output pipeline.

[0046] Among them, the heparin adjustment gear in the embodiment of the present application is set according to the blood flow in the arterial line; when the blood flow in the arterial line is smaller, the heparin adjustment gear will be larger, and the amplitude of the heparin flow in the heparin output line will be adjusted more. The user can adjust the heparin flow in the heparin output line in time to meet the blood anticoagulation requirements in the arterial line, and the safety of heparin anticoagulation is higher. For example, when the blood flow in the arterial line is: 80ml / min~90ml / min, the heparin adjustment gear is: 9ml / h; when the blood flow in the arterial line is: 90ml / min~100ml / min, the heparin adjustment gear is: 7ml / h; when the blood flow in the arterial line is: 100ml / min~110ml / min, the heparin adjustment gear is: 5ml / h; and so on.

[0047] Therefore, the embodiment of the present application can adaptively change the heparin adjustment gear according to the blood flow in the arterial line, so that the user can timely change the heparin flow in the heparin output line to meet various anticoagulation requirements in the arterial line.

[0048] In one embodiment, after the heparin pump controls the heparin output pipeline to increase the heparin flow rate in the heparin output pipeline according to the heparin adjustment gear in step S105, the method may further include: step S106.

[0049] Step S106: If the increased heparin flow rate is greater than the heparin safety flow rate corresponding to the blood flow rate in the arterial line, a first alarm signal is issued.

[0050] Specifically, under each blood flow condition in the arterial line, there is a maximum heparin flow in the heparin output line, which is the heparin safety flow; only when the heparin flow in the heparin output line is less than or equal to the heparin safety flow, the heparin connected to the arterial line is in a safe state; conversely, when the heparin flow in the heparin output line is greater than the heparin safety flow, the amount of heparin connected to the arterial line is too large, which will cause the patient to be prone to bleeding risks during the blood purification process.

[0051] In S105, after the heparin output pipeline increases the heparin flow rate in the heparin output pipeline according to the heparin adjustment gear, it is necessary to determine whether the adjusted heparin flow rate is greater than the heparin safety flow rate corresponding to the blood flow rate in the arterial pipeline, so as to prevent the heparin flow rate in the increased heparin output pipeline from being too high under a specific blood flow rate in the arterial pipeline, thereby posing a risk of bleeding to the human body. When the increased heparin flow rate is greater than the corresponding heparin safety flow rate, a first alarm signal is issued to prompt that the user's flow adjustment operation has caused the heparin flow rate in the heparin output pipeline to be too high.

[0052] It should be noted that there is a big difference between the "heparin safety flow rate" in the embodiment of the present application and the "recommended flow rate" mentioned above. The heparin safety flow rate is greater than the recommended flow rate. The recommended flow rate represents the most suitable heparin rate of the heparin output pipeline under a specific blood flow rate. For example, when the blood flow rate in the arterial pipeline is 80 ml / min, the recommended flow rate is 10 ml / h, and the heparin safety flow rate is 20 ml / h. In addition, in the embodiment of the present application, the recommended flow rate is equivalent to the initial parameter value when the blood purification equipment starts heparin anticoagulation, and the heparin safety flow rate refers to the difference between the increased heparin flow rate and the heparin safety flow rate after the heparin flow rate in the heparin output pipeline is increased.

[0053] In one embodiment, after in step S105 , the heparin pump controls the heparin output pipeline to reduce the heparin flow in the heparin output pipeline according to the heparin adjustment gear, the method may further include: step S107 .

[0054] Step S107: If the adjusted heparin flow rate is less than the heparin limit flow rate corresponding to the blood flow rate in the arterial line, a second alarm signal is issued.

[0055] Specifically, under each blood flow condition in the arterial line, there is a minimum heparin flow in the heparin output line, which is also called the heparin limit flow; when the heparin flow in the heparin output line is less than the heparin limit flow, the amount of heparin connected to the arterial line will not be able to achieve the heparin anticoagulant effect.

[0056] It should be noted that S107 and S106 have similarities, so the specific implementation of S107 can refer to the specific implementation of S106 and will not be repeated here.

[0057] In one embodiment, the method further includes: step S108 and step S109.

[0058] Step S108: detecting a first duration of the heparin output by the heparin pump.

[0059] Step S109: If the first duration is greater than a preset safety time, a third alarm signal is issued.

[0060] Specifically, since heparin is continuously returned to the human body along with the purified blood during the heparin anticoagulation process, heparin will accumulate in the human body; the preset safety time represents the appropriate time for heparin to be continuously output to the human body, wherein the preset safety time is obtained after multiple clinical trials; for example, the preset safety time is 10 hours. When it is detected that the first duration is greater than 10 hours, the human body is very likely to be at great risk of bleeding due to continuous access to heparin. Therefore, the embodiment of the present application detects the duration of the heparin output by the heparin pump to determine whether the duration of the heparin output by the heparin output pipeline is too long. When the first duration is greater than the preset safety time, a third alarm signal is issued to remind the user: the patient is very likely to be at risk of bleeding due to long-term use of heparin anticoagulation.

[0061] In one embodiment, the method further includes: step S108.

[0062] Step S108: detecting a first duration of the heparin output by the heparin pump.

[0063] At this time, step S104, controlling the display screen to display a flow adjustment button may include: if the first duration is less than or equal to the flow rate adjustable time, controlling the display screen to display the flow adjustment button.

[0064] At this time, the method further includes: step 110.

[0065] Step 110: If the first duration is greater than the flow rate adjustable time and less than or equal to a preset safety time, control the display screen to hide the flow rate adjustment button.

[0066] Specifically, the adjustable flow rate time is a pre-set value, wherein the adjustable flow rate time represents the normal blood purification period. During the normal blood purification period, the heparin output pipeline will normally output heparin to the arterial pipeline to realize the heparin anticoagulation function in the arterial pipeline; when the duration of the heparin pump outputting heparin is greater than the adjustable flow rate time, this indicates that the patient's blood purification process will soon be terminated, and the heparin anticoagulation process will also soon be terminated. In an embodiment of the present application, when the heparin pump controls the heparin output pipeline to output heparin to the arterial pipeline according to the recommended flow rate value, the time starting point from when the heparin pump starts to output heparin is taken as the time starting point. Within the adjustable flow rate time, the user can change the heparin flow in the heparin output pipeline through the flow adjustment button on the display screen; however, when the first duration is greater than the adjustable flow rate time, in this case the heparin anticoagulation process will soon be terminated, the flow adjustment button is hidden on the display screen, and the user cannot change the heparin flow in the heparin output pipeline through the flow adjustment button on the display screen, thereby avoiding the problem that the heparin anticoagulation process is prone to malfunction due to the change of heparin flow during the slow termination process of heparin anticoagulation.

[0067] Exemplarily, if the flow rate adjustable time is pre-set to 8 hours; when the first duration is less than or equal to 8 hours, the display screen displays the flow adjustment button, and the user triggers the flow adjustment button to increase or decrease the heparin flow in the heparin output pipeline; when the first duration is greater than 8 hours, the display screen hides the flow adjustment button, and the user cannot adjust the heparin flow in the heparin output pipeline.

[0068] In one embodiment, the method further includes: step S108, step S111 and step S112.

[0069] Step S108: detecting a first duration of the heparin output by the heparin pump.

[0070] Step S111: If the first duration is less than or equal to the flow rate adjustable time, control the display screen to display a curve display button.

[0071] Step S112: If it is detected that the user triggers the curve display button, the display screen is controlled to display a curve showing the change of the ratio of the heparin flow in the heparin output line to the blood flow in the arterial line over time.

[0072] Specifically, the ratio of the heparin flow rate in the heparin output line to the blood flow rate in the arterial line can reflect the amount of heparin connected to the arterial line. The actual anticoagulation status of the blood purification device can be directly understood through this ratio. Figure 6When the user triggers the curve display button on the screen, the screen will directly display the curve, and the user can directly see the volume ratio of blood in the arterial line connected to heparin. This provides a scientific reference value for medical staff to judge the safety of heparin anticoagulation for patients, bringing great convenience to users.

[0073] It should be noted that only when the first duration is less than or equal to the adjustable flow rate time, the ratio between the heparin flow in the heparin output pipeline and the blood flow in the arterial pipeline will be displayed according to the user's needs, and the ratio in this case will have a reference value; on the contrary, when the first duration is greater than the adjustable flow rate time, the ratio between the heparin flow in the heparin output pipeline and the blood flow in the arterial pipeline will not be displayed. In this case, the heparin anticoagulation process will be terminated soon, and the ratio in this case has no reference value.

[0074] In one embodiment, the method further includes: step S113 and step S114.

[0075] Step S113: Recording the cumulative amount of heparin outputted from the heparin output pipeline.

[0076] Step S114: If the accumulated amount of heparin is greater than a preset safety amount, the heparin pump is controlled to stop urgently.

[0077] Specifically, when the heparin pump controls the heparin output pipeline to output heparin according to the user's trigger, the embodiment of the present application will record the cumulative amount of heparin output by the heparin output pipeline and control the display screen to display the cumulative amount of heparin; Figure 4 As shown, for example, if the heparin output pipeline outputs heparin to the arterial pipeline according to the recommended flow rate for 6 consecutive hours, the recorded cumulative amount of heparin is: 30 ml; the anticoagulation state of the blood purification device can be obtained based on the cumulative amount of heparin.

[0078] Because when the heparin output pipeline outputs heparin to the arterial pipeline, heparin and the purified blood are returned to the human body along the venous pipeline, and heparin will accumulate in the human body. There is a limit value for the accumulation of heparin in the human body. Once this limit value is exceeded, the human body will experience heparin anticoagulation side effects. Therefore, the embodiment of the present application will pre-set a preset safety amount according to the patient's physical condition, where the preset safety amount represents: the warning value for the accumulation of heparin in the human body; when the cumulative amount of heparin output by the heparin output pipeline is greater than the preset safety amount, it is necessary to control the heparin pump to stop urgently, and the heparin output pipeline will not output heparin to the arterial pipeline to prevent the accumulation of heparin in the human body from producing side effects. Therefore, the embodiment of the present application compares the difference between the cumulative amount of heparin and the preset safety amount to prevent the cumulative amount of heparin output by the heparin output pipeline from exceeding the warning value, thereby ensuring the safety of heparin anticoagulation during blood purification treatment.

[0079] In one embodiment, the method further includes: step S115.

[0080] Step S115: detecting a first temperature of the heparin stored in the heparin pump and a second temperature of the blood in the arterial line.

[0081] At this time, step S102, if the blood flow is less than the first preset flow, controlling the display screen to display the heparin adjustment button, may include: if the blood flow is less than the first preset flow and the first temperature is greater than the second temperature, controlling the display screen to display the heparin adjustment button.

[0082] Specifically, the heparin pump is used to pre-store heparin. The heparin stored in the heparin pump is an external liquid, and the heparin stored in the heparin pump is in the outside world for a long time without any heating measures, which may cause the temperature to drop. When the arterial line draws the patient's blood out of the body, the heparin output line outputs the heparin to the arterial line, and the heparin and blood are mixed in the arterial line. If the temperature of the heparin is very low, the temperature of the heparin will cause the temperature of the blood in the arterial line to drop, which will cause the temperature of the blood to drop abnormally during the blood purification treatment, and then cause the patient to experience discomfort symptoms. Therefore, the embodiment of the present application compares the difference between the first temperature of the heparin stored in the heparin pump and the second temperature of the blood in the arterial line. Only when the first temperature is greater than the second temperature will the heparin adjustment button be displayed on the screen, and the user can adjust the heparin flow in the heparin output line through the heparin adjustment button to ensure the safety of heparin flow adjustment. On the contrary, if the first temperature is less than or equal to the second temperature, the heparin adjustment button will not be displayed on the screen, and the user cannot change the heparin flow in the heparin output line through the heparin adjustment button to avoid the malfunction that the temperature of the heparin may cause the temperature of the blood in the arterial line to drop.

[0083] In one embodiment, the method further includes: step S116.

[0084] Step S116: Detecting the liquid capacity of the heparin output pipeline.

[0085] At this time, in step S103, the step of causing the heparin pump to control the heparin output pipeline to output heparin to the arterial pipeline according to the recommended flow rate value may include: sub-step S1031 and sub-step S1032.

[0086] Sub-step S1031: If the total amount of heparin output by the heparin pump is less than the liquid capacity of the heparin output pipeline, controlling the heparin pump to output heparin to the heparin output pipeline at a heparin output rate greater than the recommended flow rate.

[0087] Sub-step S1032: If the total amount of heparin output by the heparin pump is greater than or equal to the liquid capacity of the heparin output pipeline, causing the heparin pump to control the heparin output pipeline to output heparin to the arterial pipeline according to the recommended flow rate value;

[0088] For details, please refer to Figure 2 The heparin output pipeline has a certain length. Before the heparin pump receives the heparin start command, the heparin output pipeline will be filled with water for injection. Then, when the heparin pump receives the heparin start command, the heparin pump will output heparin to the heparin output pipeline. After all the water for injection in the heparin output pipeline is discharged into the arterial pipeline, the heparin output pipeline will start to output heparin to the arterial pipeline to achieve the anticoagulant effect of heparin in the arterial pipeline. The embodiment of the present application divides the startup process of the heparin pump into two stages: in the first stage, the heparin pump operates to output heparin according to the heparin output rate and drain the water for injection in the heparin output pipeline. When the total amount of heparin output by the heparin pump is greater than or equal to the liquid capacity of the heparin output pipeline, it means that the water for injection in the heparin output pipeline has been completely drained, and the startup process of the heparin pump switches from the first stage to the second stage; in the second stage, the heparin pump operates to output heparin according to the recommended flow rate, and the heparin output pipeline outputs heparin to the arterial pipeline to achieve a heparin anticoagulant effect in the arterial pipeline; and the heparin output rate is greater than the recommended flow rate, for example, the heparin output rate is 10 ml / min and the recommended flow rate is 10 ml / h, the heparin pump will drain the water for injection in the heparin output pipeline at the fastest rate, and then output the heparin to the arterial pipeline according to the recommended flow rate to achieve the heparin anticoagulant function. Therefore, the embodiment of the present application divides the startup process of the heparin pump into two stages to output heparin at different flow rates, thereby improving the heparin anticoagulation control response speed and response sensitivity of the blood purification equipment.

[0089] In one embodiment, the method further includes: step S117 and step S118.

[0090] Step S117: detecting a third temperature of the mixed solution formed by blood and heparin in the arterial line.

[0091] Step S118: If the difference between the third temperature and the standard reference temperature does not meet the temperature safety condition, a fourth alarm signal is issued. The temperature safety condition is that the absolute value of the difference between the third temperature and the standard reference temperature is less than the preset temperature difference. The standard reference temperature is obtained by detecting the blood temperature in the arterial line when the blood flow is greater than or equal to the first preset flow.

[0092] When it is detected that the blood flow is greater than or equal to the first preset flow, the blood temperature in the arterial line is detected to obtain a standard reference temperature; when it is detected that the blood flow is greater than or equal to the first preset flow, it means that heparin anticoagulation is not required for the blood in the arterial line. In this case, the blood temperature in the arterial line is detected to obtain a standard reference temperature, which represents the most suitable blood temperature for the patient.

[0093] The temperature safety condition is expressed by a mathematical expression as follows: |third detection temperature-standard reference temperature|<preset temperature difference; the preset temperature difference is a preset amplitude.

[0094] Specifically, when the heparin pump controls the heparin output pipeline to output heparin to the arterial pipeline, blood and heparin are mixed in the arterial pipeline to obtain a mixed liquid; the embodiment of the present application determines whether the third temperature of the mixed liquid is in a fault state by comparing the difference between the third temperature of the mixed liquid and the standard reference temperature; when it is determined that the third temperature of the mixed liquid is in an excessively high fault or an excessively low fault, a third alarm signal is issued to prompt the user: the temperature of the mixed liquid is in a fault state.

[0095] Exemplarily, if the standard reference temperature detected is 36°C, the preset temperature difference is pre-set to 2°C, where the preset temperature difference represents the safe fluctuation error allowed for the human body's blood temperature; when the third temperature is 35°C, |third detection temperature-standard reference temperature|=|35°C-36°C|=1°C<2°C, the temperature safety condition has been met at this time, and the fourth alarm signal will not be issued; when the third temperature is 33°C, |third detection temperature-standard reference temperature|=|33°C-36°C|=3°C>2°C, the temperature safety condition is not met at this time, and a fourth alarm signal is issued. The fourth alarm signal is used to prompt the user: there is a temperature fault in the mixed liquid.

[0096] In one embodiment, the method further includes: step S119.

[0097] Step S119: If the blood flow rate is less than a second preset flow rate, the display screen is controlled to hide the heparin adjustment button, and the heparin pump is controlled to stop. The second preset flow rate is less than the first preset flow rate and greater than 0.

[0098] Specifically, when the heparin output pipeline outputs heparin to the arterial pipeline, the embodiment of the present application will continue to detect the blood flow in the arterial pipeline; when the blood flow is detected to be less than the second preset flow, it means that the patient's blood purification process is about to end, then it is necessary to control the display screen to hide the heparin adjustment button to terminate the heparin anticoagulation process, the heparin pump stops, and the heparin output pipeline cannot output heparin.

[0099] Exemplarily, the second preset flow rate is 0.1 ml / min; the embodiment of the present application predicts whether the patient's blood purification process is about to end based on the blood flow in the arterial line. When it is detected that the blood flow is less than the second preset flow rate, the heparin anticoagulation process is immediately terminated to prevent the heparin output from the heparin output line from being wasted, thereby saving the use of heparin.

[0100] In one embodiment, before step S102, controlling the display screen to display a heparin adjustment button if the blood flow rate is less than a first preset flow rate, the process may further include: step S120.

[0101] Step S120: Detect whether there are bubbles in the heparin output pipeline.

[0102] At this time, step S102, if the blood flow is less than the first preset flow, controlling the display screen to display the heparin adjustment button, may include: if the blood flow is less than the first preset flow and there are no bubbles in the heparin output pipeline, controlling the display screen to display the heparin adjustment button.

[0103] Specifically, before the control display screen displays the heparin adjustment button, the liquid in the heparin output line is ultrasonically detected to obtain a bubble detection result; if bubbles are detected in the heparin output line, the heparin adjustment button will not be displayed on the display screen, and the heparin anticoagulation process of the arterial line cannot be started; when it is detected that there are no bubbles in the heparin output line, it means that heparin can be output to the arterial line through the heparin output line to start the heparin anticoagulation process of the arterial line. Therefore, the embodiment of the present application detects whether there are bubbles in the heparin output line before adopting the heparin anticoagulation process to prevent the bubbles in the heparin output line from being output to the arterial line when the heparin pump is running, thereby compromising the patient's blood purification safety.

[0104] It should be noted that in the embodiment of the present application, ultrasonic testing is performed on the pipeline to determine whether there are bubbles in the pipeline. This bubble detection method is a very common bubble detection method in this field and will not be described in detail here.

[0105] It should be noted that some of the data listed in the above embodiments are only used to illustrate the technical means of the embodiment scheme of the present application, and do not mean that the embodiment of the present application will be implemented according to the data in the above embodiments during the specific implementation process.

[0106] See also Figure 7 , Figure 7This is a structural diagram of another embodiment of the blood purification device of the present application, wherein the blood purification device includes a display screen 200, an arterial line 1, a blood purifier 3, a venous line 2, a heparin pump 4, and a heparin output line 5; the arterial line 1 is connected to the blood input end of the blood purifier 3, the venous line 2 is connected to the blood output end of the blood purifier 3, and the heparin output line 5 is connected between the heparin pump 4 and the arterial line 1; the blood purification device also includes: a memory 400 and a processor 300, wherein the memory 400 is used to store a computer program; the processor 300 is used to execute the computer program and, when executing the computer program, implement the heparin control method of the blood purification device as described above. For detailed description of the relevant content, please refer to the relevant content of the heparin control method of the above-mentioned blood purification device, which will not be repeated here.

[0107] The blood purification device further includes a host 100, on which an arterial line 1, a venous line 2, a blood purifier 3, a heparin pump 4, and a heparin output line 5 are mounted. A display 200, a memory 400, and a processor 300 are connected via a bus. The memory 400 and the processor 300 may be located within or outside the host 100. The display 200 may be a conventional touch screen.

[0108] The processor 300 may be a micro control unit, a central processing unit, a digital signal processor, or the like.

[0109] The memory 400 may be a Flash chip, a read-only memory, a magnetic disk, an optical disk, a USB flash drive, or a mobile hard disk, etc.

[0110] The present application also provides a computer-readable storage medium storing a computer program, which, when executed by a processor, causes the processor to implement any of the above-described heparin control methods for blood purification devices. For detailed descriptions of the relevant content, please refer to the relevant content of the above-described heparin control method for blood purification devices, which will not be repeated here.

[0111] The computer-readable storage medium may be an internal storage unit of the blood purification device, such as a hard disk or memory. The computer-readable storage medium may also be an external storage device, such as a plug-in hard disk, smart memory card, secure digital card, flash memory card, etc.

[0112] It should be understood that the terms used in the present specification are only used to describe specific embodiments and are not intended to limit the present application.

[0113] It will also be understood that the term "and / or" used in this specification and the appended claims refers to and includes any and all possible combinations of one or more of the associated listed items.

[0114] The above descriptions are merely specific embodiments of the present application, but the scope of protection of the present application is not limited thereto. Any person skilled in the art can easily conceive of various equivalent modifications or substitutions within the technical scope disclosed in the present application, and such modifications or substitutions should be included within the scope of protection of the present application. Therefore, the scope of protection of the present application should be based on the scope of protection of the claims.

Claims

1. A blood purification device, comprising a display screen, an arterial line, a blood purifier, a venous line, a heparin pump, and a heparin output line; the arterial line is connected to a blood input end of the blood purifier, the venous line is connected to a blood output end of the blood purifier, and the heparin output line is connected between the heparin pump and the arterial line, characterized in that: The blood purification device further includes: a memory and a processor, wherein the memory is used to store a computer program; and the processor is used to execute the computer program and implement the following heparin control method of the blood purification device when executing the computer program: detecting the blood flow in the arterial line; If the blood flow rate is less than a first preset flow rate, controlling the blood purification device to issue a prompt message to prompt the user to perform heparin anticoagulation; If a heparin adjustment operation input by the user in response to the prompt information is detected, the heparin pump controls the heparin output pipeline to output heparin to the arterial pipeline according to the recommended flow rate value, and the recommended flow rate value is obtained based on the blood flow in the arterial pipeline, and there is a negative correlation between the recommended flow rate value and the blood flow in the arterial pipeline.

2. The blood purification device according to claim 1, characterized in that: The processor is configured to execute the computer program and implement the following heparin control method for a blood purification device when executing the computer program: If the blood flow rate is less than a first preset flow rate, controlling the display screen to display a heparin adjustment button; If it is detected that the user triggers the heparin adjustment button, the heparin pump controls the heparin output pipeline to output heparin to the arterial pipeline according to the recommended flow rate value.

3. The blood purification device according to claim 2, characterized in that: The processor is configured to execute the computer program and implement the following heparin control method for a blood purification device when executing the computer program: Controlling the display screen to display a flow adjustment button; If it is detected that the user triggers the flow adjustment button, the heparin pump controls the heparin output pipeline to increase or decrease the heparin flow in the heparin output pipeline according to the heparin adjustment gear, and the heparin adjustment gear is obtained according to the blood flow in the arterial pipeline.

4. The blood purification device according to claim 3, characterized in that: The processor is configured to execute the computer program and implement the following heparin control method for a blood purification device when executing the computer program: If the increased heparin flow rate is greater than the heparin safety flow rate corresponding to the blood flow rate in the arterial line, a first alarm signal is issued; and / or, If the lowered heparin flow rate is less than the heparin limit flow rate corresponding to the blood flow rate in the arterial line, a second alarm signal is issued.

5. The blood purification device according to claim 3, characterized in that: The processor is configured to execute the computer program and implement the following heparin control method for a blood purification device when executing the computer program: detecting a first duration of heparin output by the heparin pump; If the first duration is greater than a preset safety time, a third alarm signal is issued; and / or, detecting a first duration of heparin output by the heparin pump; If the first duration is less than or equal to the flow rate adjustable time, controlling the display screen to display the flow rate adjustment button; If the first duration is greater than the flow rate adjustable time and less than or equal to a preset safety time, controlling the display screen to hide the flow rate adjustment button; and / or, detecting a first duration of heparin output by the heparin pump; If the first duration is less than or equal to the flow rate adjustable time, controlling the display screen to display a curve display button; If it is detected that the user triggers the curve display button, the display screen is controlled to display a curve of the ratio of the heparin flow in the heparin output line to the blood flow in the arterial line over time.

6. The blood purification device according to claim 2, characterized in that: The processor is configured to execute the computer program and implement the following heparin control method for a blood purification device when executing the computer program: Recording the cumulative amount of heparin outputted by the heparin output pipeline; If the accumulated amount of heparin is greater than a preset safety amount, the heparin pump is controlled to stop urgently; and / or, detecting a first temperature of heparin stored in the heparin pump and a second temperature of blood in the arterial line; If the blood flow rate is less than a first preset flow rate and the first temperature is greater than the second temperature, the display screen is controlled to display a heparin adjustment button.

7. The blood purification device according to claim 6, characterized in that: The processor is configured to execute the computer program and implement the following heparin control method for a blood purification device when executing the computer program: detecting the liquid capacity of the heparin output line; If the total amount of heparin output by the heparin pump is less than the liquid capacity of the heparin output pipeline, controlling the heparin pump to output heparin to the heparin output pipeline at a heparin output rate, wherein the heparin output rate is greater than the recommended flow rate; If the total amount of heparin output by the heparin pump is greater than or equal to the liquid capacity of the heparin output pipeline, the heparin pump controls the heparin output pipeline to output heparin to the arterial pipeline according to the recommended flow rate value; and / or, detecting a third temperature of a mixed solution formed by blood and heparin in the arterial line; If the difference between the third temperature and the standard reference temperature does not meet the temperature safety condition, a fourth alarm signal is issued. The temperature safety condition is: the absolute value of the difference between the third temperature and the standard reference temperature is less than the preset temperature difference. The standard reference temperature is obtained by detecting the blood temperature in the arterial line when the blood flow is greater than or equal to the first preset flow.

8. The blood purification device according to claim 2, characterized in that: The processor is configured to execute the computer program and implement the following heparin control method for a blood purification device when executing the computer program: If the blood flow rate is less than a second preset flow rate, the display screen is controlled to hide the heparin adjustment button and the heparin pump is controlled to stop. The second preset flow rate is less than the first preset flow rate and greater than 0.

9. The blood purification device according to claim 2, characterized in that: The processor is configured to execute the computer program and implement the following heparin control method for a blood purification device when executing the computer program: detecting whether there are bubbles in the heparin output line; If the blood flow rate is less than the first preset flow rate and there are no bubbles in the heparin output pipeline, the display screen is controlled to display a heparin adjustment button.

10. A computer-readable storage medium, characterized in that The computer-readable storage medium stores a computer program, which, when executed by a processor, enables the processor to implement the heparin control method of the blood purification device according to any one of claims 1 to 9.

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