A high performance membrane-adsorption coupled oxygenator

Abstract

The present invention relates to a high-performance membrane-adsorption coupled oxygenator, which belongs to the field of medical devices. A high-performance membrane-adsorption coupled oxygenator, the oxygenator includes at least one membrane-adsorption coupled oxygenator unit, the oxygenator unit includes the following equipment units: a shell; a plurality of gas separation membranes, and at least part of the cavity formed by the gas separation membrane is filled with carbon dioxide adsorbent; a blood inlet; a blood outlet; a gas inlet; a gas outlet, wherein the gas separation membrane is at least one of a tubular membrane, a hollow fiber membrane, a flat membrane or a rolled membrane. The present invention provides a high-performance membrane-adsorption coupled oxygenator, which mainly realizes the process of removing carbon dioxide from blood and injecting oxygen by filling the oxygenator with adsorbent and separation membrane, respectively, solving the problem that the separation membrane needs to take into account both the permeability and selectivity and improve them at the same time.

Description

Technical Field

[0001] The invention relates to a high-performance membrane-adsorption coupled oxygenator, belonging to the field of medical equipment. Background Art

[0002] The extracorporeal membrane oxygenator (ECMO) has the function of regulating the carbon dioxide and oxygen content in the blood. It is an essential medical device for the treatment of acute respiratory diseases and the waiting stage for lung transplantation, and an auxiliary medical device for cardiovascular surgery. It is regarded as the last line of defense guarding the "gate of life and death" in the ICU, and it is also the ultimate weapon for rescuing critically ill patients with COVID-19.

[0003] The oxygenation process needs to meet the requirements of blood, carbon dioxide and oxygen exchange: after oxygenation, blood oxygen increases by 45ml / L, and carbon dioxide decreases by 38ml / L. Therefore, the oxygenator is required to have good permeability to carbon dioxide and oxygen to reduce the contact area between blood and membrane, and because of the small driving force of carbon dioxide mass transfer, the CO2 / O2 selectivity of the oxygenator should be around 12:1. However, due to the trade-off effect, there is no separation membrane of the oxygenator that has both high permeability and high selectivity (12:1) at this stage, and its CO2 / O2 selectivity is lower than 12:1. The membrane area of ​​the oxygenator is controlled by the CO2 removal process. In order to meet the sufficient CO2 removal, the membrane area needs to be increased. Therefore, the oxygenator developed at this stage has problems such as low blood gas exchange efficiency and large oxygenator area, which leads to low performance of ECMO oxygenator, which seriously restricts the stable and low-cost promotion and use of ECMO on a large scale. Therefore, it is urgent to develop a new oxygenator that is not strictly restricted by the selectivity and permeability of the blood gas exchange separation membrane. Summary of the invention

[0004] In view of the problems existing in the prior art, the present invention provides a high-performance membrane-adsorption coupled oxygenator. The oxygenator first controls the pressure, temperature, flow rate and other conditions of blood and gas through a flow control unit before entering the oxygenator. A gas separation membrane with high permeability to oxygen and a medical adsorbent with high adsorption performance to carbon dioxide are loaded in the oxygenator. This coupled oxygenator does not need to strictly limit the selectivity of the oxygenator membrane to CO2 / O2 to be greater than 12:1. The selectivity of the two can be adjusted by adjusting the inner membrane area, oxygen partial pressure, adsorbent type, and adsorbent amount of the oxygenator to meet the requirements of an increase of 45ml / L in O2 and a decrease of 38ml / L in CO2 after blood oxygenation. Carbon dioxide and oxygen are mainly removed from the blood through adsorbents and separation membranes to achieve carbon dioxide removal and oxygen intake, thereby solving the problem that the separation membrane used in the current membrane oxygenator must have high carbon dioxide and oxygen separation performance and permeability at the same time, and getting rid of the problem that the separation membrane that breaks through the trade-off upper limit needs to be developed to improve the performance of the oxygenator.

[0005] In order to achieve the above object, the technical solution adopted by the present invention is:

[0006] A high-performance membrane-adsorption coupled oxygenator, the oxygenator comprising at least one oxygenator unit, the oxygenator unit comprising the following equipment units:

[0007] a shell; a plurality of gas separation membranes, wherein at least a portion of the cavities formed by the gas separation membranes are filled with carbon dioxide adsorbent; a blood inlet; a blood outlet; a gas inlet; a gas outlet,

[0008] Wherein, the gas separation membrane is at least one of a tubular membrane, a hollow fiber membrane, a flat membrane or a rolled membrane.

[0009] In the present invention, the cavity formed by the gas separation membrane is preferably filled with a carbon dioxide adsorbent in an amount such that the carbon dioxide concentration in the oxygenated blood meets the relevant requirements.

[0010] In the high-performance membrane-adsorption coupled oxygenator of the present invention, the gas separation membrane and the carbon dioxide adsorbent therein transfer oxygen to the blood and remove carbon dioxide.

[0011] In the high-performance membrane-adsorption coupled oxygenator of the present invention, blood and gas flow on both sides of the gas separation membrane respectively; blood enters from the blood inlet, flows on one side of the gas separation membrane and is guided to the blood outlet; oxygen-rich gas enters from the gas inlet, flows on the other side of the gas separation membrane and is guided to the gas outlet.

[0012] In the high-performance membrane-adsorption coupled oxygenator of the present invention, the gas separation membrane has a selectivity for carbon dioxide and oxygen. CO2 / D O2 No requirement. The removal of carbon dioxide by the present invention depends on the carbon dioxide adsorbent, so the gas separation membrane D CO2 / D O2 There is no strict limitation, and in principle, the gas separation membrane only needs to have an appropriate permeability.

[0013] In the high-performance membrane-adsorption coupled oxygenator of the present invention, the adsorbent material is a molecular sieve, an organic skeleton material, graphene, activated carbon or an alkaline adsorption material medical adsorbent.

[0014] In the high-performance membrane-adsorption coupled oxygenator of the present invention, both ends of the gas separation membrane filled with adsorbent are in a closed form filled with adsorbent, or in an open form through which purge gas is passed, or in an open form through which adsorbent is filled and purge gas is passed.

[0015] In the high-performance membrane-adsorption coupled oxygenator of the present invention, the gas separation membrane filled with adsorbent can be replaced separately.

[0016] In the high-performance membrane-adsorption coupled oxygenator of the present invention, the oxygenator adjusts the membrane area and oxygen partial pressure of the gas separation membrane so that the oxygen concentration in the oxygenated blood meets the relevant requirements.

[0017] In the high-performance membrane-adsorption coupled oxygenator of the present invention, the oxygenator adjusts the type and amount of the adsorbent so that the concentration of carbon dioxide in the oxygenated blood meets relevant requirements.

[0018] In the high-performance membrane-adsorption coupled oxygenator of the present invention, the gas separation membrane is a super-hydrophobic microporous separation membrane or a super-hydrophobic dense separation membrane, or a hydrophilic dense separation membrane.

[0019] In the high-performance membrane-adsorption coupled oxygenator of the present invention, the membrane material of the gas separation membrane is an organic polymer, a molecular sieve inorganic polymer or an organic-inorganic hybrid polymer.

[0020] Preferably, the membrane material is polydimethylsiloxane, polydimethylsiloxane-polyurethane, self-microporous polymer + silicon nanoparticles, poly[1-(4-trimethylsilyl)phenyl-2-phenylethene, polydimethylsiloxane-polyurethane, fluorinated polyimide, porous ceramics, porous glass, molecular sieve, amino-modified polydimethylsiloxane, polydiphenylethene.

[0021] In the high-performance membrane-adsorption coupled oxygenator of the present invention, the oxygenator comprises a blood flow control unit, a gas flow control unit, and a membrane-adsorption coupled oxygenator unit; blood and gas are respectively adjusted in pressure, temperature and flow rate by the blood control unit and the gas flow control unit before entering the membrane-adsorption coupled oxygenator unit, in which blood and gas flow on both sides of the membrane.

[0022] A preferred technical solution of the high-performance membrane-adsorption coupled oxygenator of the present invention is:

[0023] A high-performance membrane-adsorption coupled oxygenator, the oxygenator comprising at least one oxygenator unit, the oxygenator unit comprising the following equipment units:

[0024] a shell; a plurality of hollow fiber membranes, some of the hollow fiber membrane cavities contain carbon dioxide adsorbent; a blood inlet; a blood outlet; a gas inlet; a gas outlet,

[0025] The two ends of the hollow fiber membrane M2 containing the carbon dioxide adsorbent in the cavity are sealed; the two ends of the hollow fiber membrane M1 not containing the carbon dioxide adsorbent in the cavity are open and connected to the gas inlet and the gas outlet;

[0026] The hollow fiber membranes M1 and M2 are regularly or randomly arranged in the shell along the central axis of the shell;

[0027] The blood inlet and the blood outlet are arranged perpendicular to the central axis of the shell.

[0028] A preferred technical solution of the high-performance membrane-adsorption coupled oxygenator of the present invention is:

[0029] A high-performance membrane-adsorption coupled oxygenator, the oxygenator comprising at least one oxygenator unit, the oxygenator unit comprising the following equipment units:

[0030] a housing; a roll membrane, at least part of the roll membrane cavity containing a carbon dioxide adsorbent; a blood inlet; a blood outlet; a gas inlet; a gas outlet,

[0031] The gas inlet and the gas outlet are respectively at the two ends of the core column;

[0032] The blood inlet and the blood outlet are connected to the rolled membrane cavity.

[0033] A preferred technical solution of the high-performance membrane-adsorption coupled oxygenator of the present invention is:

[0034] A high-performance membrane-adsorption coupled oxygenator, the oxygenator comprising at least one oxygenator unit, the oxygenator unit comprising the following equipment units:

[0035] a shell; a plate membrane, part of the plate membrane cavity contains a carbon dioxide adsorbent; a blood inlet; a blood outlet; a gas inlet; a gas outlet,

[0036] The plate-type membrane is composed of two membranes in a group to form a sandwich structure, thereby forming a raw material chamber and an osmotic chamber, and blood flows outside the sandwich structure;

[0037] The gas flows in the inner cavity of the sandwich structure through the porous core column, and the adsorbent is filled in the membrane cavity of part of the sandwich structure.

[0038] The beneficial effects of the present invention are as follows: in order to improve the efficiency of the blood oxygenation process and avoid some adverse effects, the separation membrane of the oxygenator is required to have a CO2 / O2 selectivity of about 12:1 while ensuring a relatively high permeability. However, due to the upper limit of the trade-off of separation membranes at this stage, the development of gas separation membranes with both high permeability and high selectivity has always been a global problem. The present invention provides a high-performance membrane-adsorption coupled oxygenator, which mainly realizes the process of removing carbon dioxide from blood and injecting oxygen by loading adsorbents and separation membranes in the oxygenator, respectively, solving the problem that the separation membrane needs to simultaneously improve both permeability and selectivity. The high-performance membrane-adsorption coupled oxygenator provided by the present invention only needs to consider that the adsorbent has high adsorption of carbon dioxide and the separation membrane has high permeability to oxygen, and there is no need to strictly consider whether the separation membrane performance of carbon dioxide and oxygen can reach 12:1. The performance of the oxygenator can be achieved by adjusting the adsorbent, purge gas, separation membrane and oxygen partial pressure to achieve an increase of 45 ml / L in blood oxygen and a decrease of 38 ml / L in carbon dioxide after oxygenation, thereby getting rid of the difficult problem of developing an oxygenator that breaks through the trade-off upper limit and has high permeability and high selectivity to carbon dioxide and oxygen to improve the performance of the oxygenator. BRIEF DESCRIPTION OF THE DRAWINGS

[0039] Figure 1 This is a schematic diagram of the high-performance membrane-adsorption coupled oxygenator described in Example 1.

[0040] Figure 2 This is a schematic diagram of the shell of the high-performance membrane-adsorption coupled oxygenator described in Example 1.

[0041] Figure 3 This is a schematic cross-sectional view of the high-performance membrane-adsorption coupled oxygenator described in Example 1.

[0042] Figure 4 Schematic diagram of the gas exchange process of the high-performance membrane-adsorption coupled oxygenator described in Example 1.

[0043] Figure 5 Schematic diagram of the high-performance membrane-adsorption coupled oxygenator M-1 membrane described in Example 1.

[0044] Figure 6 Schematic diagram of the high-performance membrane-adsorption coupled oxygenator M-2 membrane described in Example 1.

[0045] Figure 7 This is the principle process of the high-performance membrane-adsorption coupled oxygenator described in Example 1.

[0046] In the figure: D-1 blood flow control unit, D-2 gas flow control unit, D-3 membrane-adsorption coupled oxygenator unit: M-1 membrane mainly permeable to oxygen, carbon dioxide adsorbent P-1, M-2 membrane filled with medical carbon dioxide medical adsorbent P-1, blood inlet 101, blood outlet 102, gas inlet 103, gas outlet 104, sealing port 105, hollow fiber membrane filament 106, oxygenator cavity 107, oxygenator sealing end 108, M-1 membrane gas inlet 110, M-1 membrane gas outlet 111.

[0047] Figure 8 This is a schematic diagram of the high-performance membrane-adsorption coupled oxygenator described in Example 2.

[0048] Fig. 9 This is a schematic diagram of the membrane cavity of the high-performance membrane-adsorption coupled oxygenator described in Example 2.

[0049] In the figure: core column 201, sealing end 202, diaphragm net 203, gas exchange membrane 204, screen 205, shell 206, blood inlet 207, blood outlet 208, gas inlet 209, gas outlet 210, carbon dioxide medical adsorbent 211.

[0050] Fig.10 It is a schematic diagram of the plate-type membrane sandwich structure of the high-performance membrane-adsorption coupled oxygenator described in Example 3.

[0051] Fig.11 Schematic diagram of the high-performance membrane-adsorption coupled oxygenator described in Example 3.

[0052] In the figure: gas exchange membrane 301 and spacer 302. DETAILED DESCRIPTION

[0053] The following non-limiting embodiments may enable a person skilled in the art to more fully understand the present invention, but are not intended to limit the present invention in any way.

[0054] The test methods described in the following examples are conventional methods unless otherwise specified; the reagents and materials described are commercially available unless otherwise specified.

[0055] In the following embodiment, a high-performance membrane-adsorption coupled oxygenator is implemented based on a coupled oxygenator for gas exchange between blood and carbon dioxide and oxygen. The coupled oxygenator includes: D-1 blood flow control unit, D-2 gas flow control unit, and D-3 membrane-adsorption coupled oxygenator unit.

[0056] Example 1

[0057] The membrane module is a hollow fiber membrane module

[0058] A high-performance membrane-adsorption coupled oxygenator is realized based on a coupled oxygenator for gas exchange between blood, carbon dioxide and oxygen. The coupled oxygenator comprises: a D-1 blood flow control unit, a D-2 gas flow control unit, and a D-3 membrane-adsorption coupled oxygenator unit.

[0059] The D-3 membrane-adsorption coupled oxygenator unit is composed of an M-1 membrane that is mainly permeable to oxygen, a carbon dioxide adsorbent P-1, and an M-2 membrane filled with a medical carbon dioxide adsorbent P-1. The two ends of the hollow fiber membrane M2 whose cavity contains a carbon dioxide adsorbent are sealed; the two ends of the hollow fiber membrane M1 whose cavity does not contain a carbon dioxide adsorbent are open and connected to a gas inlet and a gas outlet. Blood and gas flow on both sides of the gas separation membrane respectively; blood enters from the blood inlet, flows on one side of the gas separation membrane and is guided to the blood outlet; high-purity oxygen enters from the gas inlet, flows on the other side of the gas separation membrane and is guided to the gas outlet.

[0060] The M-1 membrane is polydimethylsiloxane (PDMS) with an oxygen permeability of 150 GPU and a carbon dioxide permeability of 1000 GPU.

[0061] The membrane area of ​​M-1 membrane is 390 cm 2 .

[0062] The membrane area of ​​M-2 membrane is 390 cm 2 .

[0063] The P-1 adsorbent is a calcium hydroxide type adsorbent with an adsorption efficiency of 80% and a usage amount of 178 g.

[0064] The M-1 membrane and the M-2 membrane are arranged alternately horizontally, and the number of the M-1 membrane and the M-2 membrane only needs to meet the membrane area requirements of both. After the adsorption performance of the M-2 membrane decays, the M-2 membrane can be replaced by opening the oxygenator cap.

[0065] The specific process is as follows:

[0066] The blood used in the high-performance membrane-adsorption coupled oxygenator provided by the present invention is adult venous blood, and the use time is 3 days.

[0067] Blood F-1 and gas G-1 are first adjusted by the D-1 and D-2 control units to adjust the pressure and temperature conditions of the blood and gas. After adjustment, the blood flow rate is 5.55L / min, the blood temperature is 37°C, the blood pressure is 100KPa, the high-purity oxygen flow rate is 11.10L / min, the gas temperature is 37°C, and the gas pressure is 100KPa. Then they enter the D-3 membrane-adsorption coupled oxygenator unit. In the D-3 membrane-adsorption coupled oxygenator, blood flows on the outside of the membrane, high-purity oxygen flows on the inside of the M-1 membrane, the adsorbent is filled in the M-2 membrane, and both ends of the M-2 membrane are closed. After the blood is oxygenated by the D-3 membrane-adsorption coupled oxygenator unit, the blood O2 increases by 45ml / L and the CO2 decreases by 38ml / L.

[0068] Example 2

[0069] The membrane module is a spiral membrane module

[0070] The blood used in the high-performance membrane-adsorption coupled oxygenator provided by the present invention is adult venous blood, and the use time is 3 days.

[0071] Blood F-1 and gas G-1 are first adjusted by the D-1 and D-2 control units to adjust the pressure and temperature conditions of the blood and gas. After the adjustment, the blood flow rate is 5.55L / min, the blood temperature is 37°C, the blood pressure is 100KPa, the high-purity oxygen flow rate is 11.10L / min, the gas temperature is 37°C, and the gas pressure is 100KPa. Then they enter the D-3 membrane-adsorption coupled oxygenator unit. In the D-3 membrane-adsorption coupled oxygenator, the membrane assembly is a roll-type membrane assembly, and the gas inlet and gas outlet are the two ends of the core column respectively; the blood inlet and blood outlet are connected to the roll-type membrane cavity. The blood flows outside the three-sided sealed membrane cavity composed of two membranes, and the high-purity oxygen flows inside the membrane through the core column. The adsorbent is filled in the membrane cavity. After the blood is oxygenated by the D-3 membrane-adsorption coupled oxygenator unit, the blood O2 increases by 45ml / L and CO2 decreases by 38ml / L.

[0072] The M-1 membrane is polydimethylsiloxane (PDMS) with an oxygen permeability of 200 GPU and a carbon dioxide permeability of 1500 GPU.

[0073] The membrane area of ​​M-1 membrane is 291 cm 2 .

[0074] The membrane area of ​​M-2 membrane is 227 cm 2 .

[0075] The P-1 adsorbent is a calcium hydroxide type adsorbent with an adsorption efficiency of 80% and a usage amount of 156 g.

[0076] The adsorbent is evenly distributed in the entire membrane cavity.

[0077] Example 3

[0078] The membrane module is a plate membrane module

[0079] The blood used in the high-performance membrane-adsorption coupled oxygenator provided by the present invention is adult venous blood, and the use time is 3 days.

[0080] Blood F-1 and gas G-1 are first adjusted by the D-1 and D-2 control units respectively to adjust the pressure and temperature conditions of blood and gas. After adjustment, the blood flow rate is 5.55L / min, the blood temperature is 37°C, the blood pressure is 100KPa, the high-purity oxygen flow rate is 11.10L / min, the gas temperature is 37°C, and the gas pressure is 100KPa. Then they enter the D-3 membrane-adsorption coupled oxygenator unit. In the D-3 membrane-adsorption coupled oxygenator, a group of two membranes form a sandwich structure, thereby forming a raw material cavity and a permeation cavity. The blood flows outside the sandwich structure, and the high-purity oxygen flows in the inner cavity of the sandwich structure through the porous core column. The adsorbent is filled in the membrane cavity of part of the sandwich structure. After the blood is oxygenated by the D-3 membrane-adsorption coupled oxygenator unit, the blood O2 increases by 45ml / L and the CO2 decreases by 38ml / L.

[0081] The membrane material is polydimethylsiloxane-polyurethane (PDMS-PU), with an oxygen permeability of 360 GPU and a carbon dioxide permeability of 1224 GPU.

[0082] M-1 membrane area is 162 cm 2 .

[0083] The membrane area of ​​M-2 membrane is 472 cm 2 .

[0084] The P-1 adsorbent is a calcium hydroxide type adsorbent with an adsorption efficiency of 80% and a usage of 265 g.

[0085] The adsorbent is evenly distributed in the entire membrane cavity of M-2.

[0086] Example 4

[0087] The membrane module is a spiral membrane module

[0088] The blood used in the high-performance membrane-adsorption coupled oxygenator provided by the present invention is adult venous blood, and the use time is 3 days.

[0089] Blood F-1 and gas G-1 are first adjusted by the D-1 and D-2 control units to adjust the pressure and temperature conditions of the blood and gas. After the adjustment, the blood flow rate is 5.55L / min, the blood temperature is 37°C, the blood pressure is 100KPa, the high-purity oxygen flow rate is 11.10L / min, the gas temperature is 37°C, and the gas pressure is 100KPa. Then they enter the D-3 membrane-adsorption coupled oxygenator unit. In the D-3 membrane-adsorption coupled oxygenator, the membrane assembly is a roll-type membrane assembly, and the gas inlet and gas outlet are the two ends of the core column respectively; the blood inlet and blood outlet are connected to the roll-type membrane cavity. The blood flows outside the three-sided sealed membrane cavity composed of two membranes, and the high-purity oxygen flows inside the membrane through the core column. The adsorbent is filled in the membrane cavity. After the blood is oxygenated by the D-3 membrane-adsorption coupled oxygenator unit, the blood O2 increases by 45ml / L and CO2 decreases by 38ml / L.

[0090] The membrane material is fluorinated polyimide (6FDA-durene) with an oxygen permeability of 125 GPU and a carbon dioxide permeability of 456 GPU.

[0091] M-1 membrane area is 465 cm 2 .

[0092] The membrane area of ​​M-2 membrane is 1235 cm 2 .

[0093] The P-1 adsorbent is a calcium hydroxide type adsorbent with an adsorption efficiency of 80% and a usage of 258 g.

[0094] The adsorbent is evenly distributed in the entire membrane cavity.

[0095] Example 5

[0096] The membrane module is a hollow fiber membrane

[0097] The blood used in the high-performance membrane-adsorption coupled oxygenator provided by the present invention is adult venous blood, and the use time is 3 days.

[0098] Blood F-1 and gas G-1 are first adjusted by the D-1 and D-2 control units to adjust the pressure and temperature conditions of the blood and gas. After adjustment, the blood flow rate is 5.55L / min, the blood temperature is 37°C, the blood pressure is 100KPa, the high-purity oxygen flow rate is 11.10L / min, the gas temperature is 37°C, and the gas pressure is 100KPa. Then they enter the D-3 membrane-adsorption coupled oxygenator unit. In the D-3 membrane-adsorption coupled oxygenator, blood flows on the outside of the membrane, high-purity oxygen flows on the inside of the M-1 membrane, the adsorbent is filled in the M-2 membrane, and both ends of the M-2 membrane are closed. After the blood is oxygenated by the D-3 membrane-adsorption coupled oxygenator unit, the blood O2 increases by 45ml / L and the CO2 decreases by 38ml / L.

[0099] The membrane material is poly[1-(4-trimethylsilyl)phenyl-2-phenylethynylene (PTMSDPA), with an oxygen permeability of 400 GPU and a carbon dioxide permeability of 1675 GPU.

[0100] M-1 membrane area is 146 cm 2 .

[0101] The membrane area of ​​M-2 membrane is 318 cm 2 .

[0102] The P-1 adsorbent is a calcium hydroxide type adsorbent with an adsorption efficiency of 80% and a usage of 243 g.

[0103] The M-1 membrane and the M-2 membrane are arranged alternately horizontally, and the number of the M-1 membrane and the M-2 membrane only needs to meet the membrane area requirements of both. After the adsorption performance of the M-2 membrane decays, the M-2 membrane can be replaced by opening the oxygenator cap.

[0104] Example 6

[0105] The membrane module is a spiral membrane module

[0106] The blood used in the high-performance membrane-adsorption coupled oxygenator provided by the present invention is adult venous blood, and the use time is 3 days.

[0107] Blood F-1 and gas G-1 are first adjusted by the D-1 and D-2 control units to adjust the pressure and temperature conditions of the blood and gas. After the adjustment, the blood flow rate is 5.55L / min, the blood temperature is 37°C, the blood pressure is 100KPa, the high-purity oxygen flow rate is 11.10L / min, the gas temperature is 37°C, and the gas pressure is 100KPa. Then they enter the D-3 membrane-adsorption coupled oxygenator unit. In the D-3 membrane-adsorption coupled oxygenator, the membrane assembly is a roll-type membrane assembly, and the gas inlet and gas outlet are the two ends of the core column respectively; the blood inlet and blood outlet are connected to the roll-type membrane cavity. The blood flows outside the three-sided sealed membrane cavity composed of two membranes, and the high-purity oxygen flows inside the membrane through the core column. The adsorbent is filled in the membrane cavity. After the blood is oxygenated by the D-3 membrane-adsorption coupled oxygenator unit, the blood O2 increases by 45ml / L and CO2 decreases by 38ml / L.

[0108] The membrane material is self-microporous polymer + silicon nanoparticles (PIM-1+Si), with an oxygen permeability of 670 GPU and a carbon dioxide permeability of 3000 GPU.

[0109] M-1 membrane area is 87 cm 2 .

[0110] The membrane area of ​​M-2 membrane is 172 cm 2 .

[0111] The P-1 adsorbent is a calcium hydroxide type adsorbent with an adsorption efficiency of 80% and a usage of 235 g.

[0112] The adsorbent is evenly distributed in the entire membrane cavity.

[0113] Comparative Example 1

[0114] Only the M-1 membrane in Example 1 was used for the blood oxygenation process (ie, not coupled with the adsorbent), and other processes and components were the same as in Example 1. The blood used was adult venous blood, and the usage time was 3 days.

[0115] Blood F-1 and gas G-1 are first adjusted by the D-1 and D-2 control units to adjust the pressure and temperature of the blood and gas. After adjustment, the blood flow rate is 5.55L / min, the blood temperature is 37°C, the blood pressure is 100KPa, the high-purity oxygen flow rate is 11.10L / min, the gas temperature is 37°C, and the gas pressure is 100KPa. Then they enter the D-3 membrane-adsorption coupled oxygenator unit (the M-2 membrane is not filled with adsorbent). In the D-3 oxygenator, blood flows outside the membrane and high-purity oxygen flows inside the M-1 membrane.

[0116] The membrane material is polydimethylsiloxane (PDMS), with an oxygen permeability of 150 GPU and a carbon dioxide permeability of 1000 GPU.

[0117] To ensure that the blood oxygenation by the D-3 oxygenator unit increases the blood O2 by 45 ml / L, the M-1 membrane area is 390 cm 2 The amount of carbon dioxide removed is 18ml / L. Insufficient carbon dioxide removal will lead to blood acidosis.

[0118] Comparative Example 2

[0119] Only the membrane in Example 6 was used for the blood oxygenation process (ie, not coupled with an adsorbent), and other processes and components were the same as in Example 6. The blood used was adult venous blood, and the usage time was 3 days.

[0120] Blood F-1 and gas G-1 are first adjusted by the D-1 and D-2 control units to adjust the pressure and temperature of the blood and gas. After adjustment, the blood flow rate is 5.55L / min, the blood temperature is 37°C, the blood pressure is 100KPa, the high-purity oxygen flow rate is 11.10L / min, the gas temperature is 37°C, and the gas pressure is 100KPa. Then they enter the D-3 membrane-adsorption coupled oxygenator unit (the M-2 membrane is not filled with adsorbent). In the D-3 oxygenator, blood flows outside the membrane and high-purity oxygen flows inside the M-1 membrane.

[0121] The membrane material is self-microporous polymer + silicon nanoparticles (PIM-1+Si), with an oxygen permeability of 670 GPU and a carbon dioxide permeability of 3000 GPU.

[0122] To ensure that the blood oxygenation by the D-3 oxygenator unit increases the blood O2 by 45 ml / L, the M-1 membrane area is 87 cm 2 The amount of carbon dioxide removed is 12ml / L. Insufficient carbon dioxide removal will lead to blood acidosis.

[0123] The above-described embodiments merely express the implementation methods of the present invention, but they cannot be understood as limiting the scope of the patent of the present invention. It should be pointed out that for those skilled in the art, several modifications and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention.

Claims

1. A high-performance membrane-adsorption coupled oxygenator, the oxygenator comprising at least one membrane-adsorption coupled oxygenator unit, the oxygenator unit comprising the following equipment units: a shell; a plurality of gas separation membranes, wherein at least a portion of the cavities formed by the gas separation membranes are filled with carbon dioxide adsorbent; a blood inlet; a blood outlet; a gas inlet; a gas outlet, in, The gas separation membrane is at least one of a tubular membrane, a hollow fiber membrane, a flat membrane or a spiral membrane.

2. The oxygenator according to claim 1, characterized in that: The gas separation membrane and the carbon dioxide adsorbent therein transfer oxygen to the blood and remove carbon dioxide.

3. The oxygenator according to claim 1, characterized in that: Blood and gas flow on both sides of the gas separation membrane respectively; blood enters from the blood inlet, flows on one side of the gas separation membrane and is guided to the blood outlet; oxygen-rich gas enters from the gas inlet, flows on the other side of the gas separation membrane and is guided to the gas outlet.

4. The oxygenator according to claim 1, characterized in that: The gas separation membrane is selective for carbon dioxide and oxygen. CO2 / D O2 No requirements.

5. The oxygenator according to claim 1, characterized in that: The adsorbent material is molecular sieve, organic framework material, graphene, activated carbon or alkaline adsorbent material medical adsorbent.

6. The oxygenator according to claim 1, characterized in that: Both ends of the gas separation membrane loaded with adsorbent are in a closed form with adsorbent loaded, in an open form with purge gas passing therethrough, or in an open form with adsorbent loaded therethrough and purge gas passing therethrough.

7. The oxygenator according to claim 1, characterized in that: The gas separation membranes filled with adsorbent can be replaced individually.

8. The oxygenator according to claim 1, characterized in that: The oxygenator adjusts the membrane area and oxygen partial pressure of the gas separation membrane so that the oxygen concentration in the oxygenated blood meets the relevant requirements.

9. The oxygenator according to claim 1, characterized in that: The oxygenator adjusts the type and amount of the adsorbent so that the concentration of carbon dioxide in the oxygenated blood meets relevant requirements.

10. The oxygenator according to claim 1, characterized in that: The gas separation membrane is a super-hydrophobic microporous separation membrane or a super-hydrophobic dense separation membrane, or a hydrophilic dense separation membrane.

11. The oxygenator according to claim 1, characterized in that: The membrane material of the gas separation membrane is an organic polymer, a molecular sieve inorganic polymer or an organic-inorganic hybrid polymer.

12. The oxygenator according to claim 11, characterized in that: The membrane material is polydimethylsiloxane, polydimethylsiloxane-polyurethane, self-microporous polymer+silicon nanoparticles, poly[1-(4-trimethylsilyl)phenyl-2-phenylethene, polydimethylsiloxane-polyurethane, fluorine-containing polyimide, porous ceramics, porous glass, molecular sieve, amino-modified polydimethylsiloxane, and polydiphenylethene.

13. The oxygenator according to claim 1, characterized in that: The oxygenator comprises a blood flow control unit, a gas flow control unit and a membrane-adsorption coupled oxygenator unit; blood and gas are respectively adjusted in pressure, temperature and flow rate by the blood control unit and the gas flow control unit before entering the membrane-adsorption coupled oxygenator unit, in which the blood and gas flow on both sides of the membrane.

14. The oxygenator according to claim 1, characterized in that: The oxygenator comprises at least one oxygenator unit, wherein the oxygenator unit comprises the following equipment units: a shell; a plurality of hollow fiber membranes, some of the hollow fiber membrane cavities contain carbon dioxide adsorbent; a blood inlet; a blood outlet; a gas inlet; a gas outlet, The two ends of the hollow fiber membrane M2 containing the carbon dioxide adsorbent in the cavity are sealed; the two ends of the hollow fiber membrane M1 not containing the carbon dioxide adsorbent in the cavity are open and connected to the gas inlet and the gas outlet; The hollow fiber membranes M1 and M2 are regularly or randomly arranged in the shell along the central axis of the shell; The blood inlet and the blood outlet are arranged perpendicular to the central axis of the shell.

15. The oxygenator according to claim 1, characterized in that: The oxygenator comprises at least one oxygenator unit, wherein the oxygenator unit comprises the following equipment units: a housing; a roll membrane, at least part of the roll membrane cavity containing a carbon dioxide adsorbent; a blood inlet; a blood outlet; a gas inlet; a gas outlet, The gas inlet and the gas outlet are respectively at the two ends of the core column; The blood inlet and the blood outlet are connected to the rolled membrane cavity.

16. The oxygenator according to claim 1, characterized in that: The oxygenator comprises at least one oxygenator unit, wherein the oxygenator unit comprises the following equipment units: a shell; a plate membrane, part of the plate membrane cavity contains a carbon dioxide adsorbent; a blood inlet; a blood outlet; a gas inlet; a gas outlet, The plate-type membrane is composed of two membranes in a group to form a sandwich structure, thereby forming a raw material chamber and an osmotic chamber, and blood flows outside the sandwich structure; The gas flows in the inner cavity of the sandwich structure through the porous core column, and the adsorbent is filled in the membrane cavity of part of the sandwich structure.

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