A reagent mixing system and a chemiluminescent immunoassay analyzer

Abstract

This application relates to a reagent mixing system and a chemiluminescent immunoassay analyzer. The reagent mixing system includes a central ring, a carrier plate, and a first reagent bottle. The carrier plate surrounds the outside of the central ring and rotates relative to the central ring. The first reagent bottle is torsionally fixed on the carrier plate. An action part is provided on the first reagent bottle, and a trigger part is correspondingly provided on the central ring. The action part and the trigger part are respectively located on the sides of the first reagent bottle and the central ring facing each other. When the carrier plate rotates to the corresponding positions of the action part and the trigger part, the trigger part contacts the action part and causes the first reagent bottle to twist around its fixed position on the carrier plate; wherein, a plurality of mixing bases are arranged at intervals along the circumferential direction on the carrier plate, and the mixing bases are used to torsionally fix the first reagent bottle on the carrier plate. The reagent mixing system provided by the embodiments of this application has a simple and compact structure, and the mixing of the reagent in the first reagent bottle can be realized by the contact and collision between the action part and the trigger part. Since the force applied during the collision causes the first reagent bottle to generate an acceleration, the mixing effect of the reagent in the first reagent bottle can be improved.

Description

Technical Field

[0001] The present application relates to the technical field of medical testing equipment, and particularly to a reagent mixing system and a chemiluminescence immunoassay analyzer. Background Art

[0002] A chemiluminescence immunoassay analyzer is a tool for diagnosing some diseases using immunoassay technology. The chemiluminescence immunoassay analyzer mainly includes devices such as a sample library, a reagent warehouse, and an incubation plate. Among them, the reagent warehouse is a device in the chemiluminescence immunoassay analyzer responsible for providing reaction reagents. Since the reagent contains solid-phase reagents, in order to obtain a uniformly distributed solid-phase reagent, the solid-phase reagent in the reagent warehouse needs to be kept in a mixed state so that a uniformly mixed reagent can be obtained when the reagent needle extracts the solid-phase reagent. Currently, most of the mixing devices in the prior art have complex structures and high prices, resulting in high later maintenance costs, which to a certain extent limits the popularization and application of the mixing technology. In addition, some mixing devices may cause cross-infection because they use a stirring rod to mix the reagent. In addition, in some reagent mixing devices, the reagent bottle is in a uniform speed state during mixing, resulting in the inability to mix the reagent inside evenly, and even wall hanging phenomenon may occur. Summary of the Invention

[0003] In view of the technical problems existing in the prior art, the present invention provides a reagent mixing system and an immunoassay. By using the contact and collision between the action part and the trigger part, the purpose of mixing the reagent in the first reagent bottle is achieved. The reagent mixing system proposed in the embodiment of the present application has a simple and compact structure, can achieve variable-speed mixing of the reagent in the first reagent bottle, and improves the mixing effect of the reagent.

[0004] The embodiment of the present application provides a reagent mixing system, including: a central ring, a carrier plate, and a first reagent bottle. The carrier plate surrounds the outside of the central ring and rotates relative to the central ring. It is characterized in that the first reagent bottle is torsionally fixed on the carrier plate. An action part is provided on the first reagent bottle, and a trigger part is correspondingly provided on the central ring. The action part and the trigger part are respectively located on the sides of the first reagent bottle and the central ring facing each other. When the carrier plate rotates to the corresponding position of the action part and the trigger part, the trigger part contacts the action part and causes the first reagent bottle to twist around its fixed position on the carrier plate; wherein, a plurality of mixing bases are arranged at intervals along the circumferential direction on the carrier plate, and the mixing bases are used to torsionally fix the first reagent bottle on the carrier plate.

[0005] Optionally, the mixing base includes a bottom support, an elastic element, and a bottom support ring. One end of the elastic element is fixedly connected to the carrier plate, and the other end is connected to the bottom support. The elastic element is used to make the bottom support rotate reciprocally. The bottom support is arranged above the elastic element and connected to the bottom of the first reagent bottle. The action part is arranged on the side of the bottom support. The bottom support is used to transfer the rotational movement to the first reagent bottle. The bottom support ring is fixed on the carrier plate, and a first groove is provided inside the bottom support ring. A protrusion is provided at a position corresponding to the first groove below the bottom support, and the protrusion is rotatably connected to the first groove.

[0006] Optionally, the collision part between the trigger part and the action part is made of an elastic material.

[0007] Optionally, the action part is a first arc-shaped lug, and the trigger part is a ball head plunger. A first positioning hole is provided on the arc-shaped lug, and a second positioning hole is provided on the carrier plate. The elastic element is a torsion spring. One end of the torsion spring is fixed in the first positioning hole, and the other end is fixed in the second positioning hole. When the carrier plate rotates, the ball head plunger abuts against the arc-shaped lug, and the torsion spring is torsionally deformed, causing the first reagent bottle to rotate relative to the carrier plate.

[0008] Optionally, the action part is a first triangular protrusion, and the trigger part is a cylindrical protrusion, and a spring is provided inside the cylindrical protrusion. Or, the action part is a second triangular protrusion, and the trigger part is a second arc-shaped lug, and a spring is provided inside the arc-shaped lug.

[0009] Optionally, transmission parts are correspondingly provided on the first reagent bottle and the inner side of the bottom support, so that the first reagent bottle and the bottom support rotate in the same direction.

[0010] Optionally, the transmission part includes: a second groove arranged along the axial direction on the side of the first reagent bottle and a triangular convex rib arranged on the inner side of the bottom support; the triangular convex rib is embedded in the second groove, and when the bottom support rotates, it drives the first reagent bottle to rotate. Or, the transmission part includes: a claw arranged at the bottom of the first reagent bottle and a convex tooth arranged on the inner side of the bottom support; the claw meshes with the convex tooth, and when the bottom support rotates, it drives the first reagent bottle to rotate. Or, the transmission part includes: an arc-shaped convex strip arranged along the axial direction on the side of the first reagent bottle and an arc-shaped convex rib arranged on the inner side of the bottom support; the arc-shaped convex strip meshes with the arc-shaped convex rib, and when the bottom support rotates, it drives the first reagent bottle to rotate.

[0011] Optionally, the mixing system further includes: a positioning disk, which is arranged above the central ring and connected to the carrier plate. Mixing positions are provided at positions corresponding to the mixing base on the positioning disk.

[0012] Optionally, the first reagent bottle is placed in the mixing position, and the mixing position is used to limit the movement of the first reagent bottle in the circumferential direction.

[0013] Optionally, the mixing system further includes: a reagent kit located within a mixing slot, the reagent kit being configured to hold a first reagent bottle, a second reagent bottle, and a third reagent bottle.

[0014] Optionally, the diameter of the first reagent bottle decreases along the axial direction from the bottle mouth to the bottle bottom, and a one-way chamfer is provided on the side surface of the first reagent bottle to limit the movement of the first reagent bottle along the axial direction.

[0015] Optionally, symbols are marked on the positioning disk, and the positions of the symbols correspond one-to-one with the positions of the mixing slots, and the symbols are used to mark the positions of the mixing slots.

[0016] Optionally, the mixing system further includes: a housing and a housing cover, a central ring and a carrier plate are disposed within the housing, and the housing cover is disposed above the housing.

[0017] Optionally, the housing cover includes a first housing cover and a second housing cover. The second housing cover is connected to the housing, and a reagent outlet corresponding to the mixing slot is provided on the second housing cover. The reagent outlet is for the outlet when the reagent in the reagent bottle is aspirated by a reagent needle; the first housing cover is movably connected to the second housing cover, and the center of the first housing cover is offset from the center of the second housing cover by a preset distance.

[0018] Optionally, a sensor is provided on the second housing cover, and a signal transmitter is provided at a position corresponding to the sensor on the first housing cover. The sensor is configured to sense the placement state of the first housing cover; wherein, the sensor is a Hall sensor and the signal transmitter is a magnetic element.

[0019] Optionally, the system further includes a barcode scanner provided outside the housing for scanning and reading information of the reagent kit.

[0020] Optionally, the system further includes: a refrigeration unit disposed below the housing for maintaining the temperature of the housing within a preset range; an air duct including a fan and a baffle. The baffle encloses a channel disposed below the refrigeration unit, and the fan is provided at the outlet of the channel for discharging heat generated by the refrigeration unit.

[0021] This application also provides a chemiluminescent immunoassay analyzer, which includes an incubation disk and further includes the reagent mixing system as described in any one of the foregoing items. The reagent mixing system is configured to provide the mixed reagent to a reaction tube located in the incubation disk.

[0022] By providing an actuating portion and a triggering portion and using the contact collision between the triggering portion and the actuating portion to complete the mixing of the reagent in the first reagent bottle, the reagent mixing system provided in the embodiments of this application has a simple and compact structure and can complete the mixing of the reagent without requiring many power structures. Additionally, since the force applied during the collision causes the first reagent bottle to generate an acceleration, the mixing effect of the reagent in the first reagent bottle can be improved. Compared with other uniform mixing techniques, the acceleration mixing technique has greater advantages in mixing reagents. Brief Description of the Drawings

[0023] Next, the preferred embodiments of the present invention will be further described in detail with reference to the accompanying drawings, where:

[0024] Figure 1 is a schematic diagram of a partial structure of a reagent mixing system according to an embodiment of the present application;

[0025] Figure 2 is a schematic diagram of the mixing base structure of a reagent mixing system according to an embodiment of the present application;

[0026] Figure 3 is a schematic diagram of the structures of the actuating part and the triggering part in another reagent mixing system according to an embodiment of the present application;

[0027] Figure 4 is a schematic diagram of the structures of the actuating part and the triggering part in yet another reagent mixing system according to an embodiment of the present application;

[0028] Figure 5 is a schematic diagram of the structure of another transmission part proposed in an embodiment of the present application;

[0029] Figure 6 is a schematic diagram of the structure of yet another transmission part proposed in an embodiment of the present application;

[0030] Figure 7 is a schematic diagram of a partial structure of another reagent mixing system according to an embodiment of the present application;

[0031] Figure 8 is a sectional view of the structure of a reagent kit proposed in an embodiment of the present application;

[0032] Figure 9 is a schematic diagram of the structure of yet another reagent mixing system proposed in an embodiment of the present application;

[0033] Figure 10 is Figure 9 a partial sectional view. Detailed Embodiments

[0034] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are some, but not all, of the embodiments of the present invention. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0035] In the following detailed description, reference is made to the various specification drawings that form a part of the present application and illustrate specific embodiments of the present application. In the drawings, like reference numerals generally describe substantially similar components in different figures. The various specific embodiments of the present application are described in sufficient detail below to enable those of ordinary skill in the relevant art and technology to implement the technical solutions of the present application. It should be understood that other embodiments may also be utilized or structural, logical, or electrical changes may be made to the embodiments of the present application.

[0036] Figure 1 is a partial structural schematic diagram of a reagent mixing system according to an embodiment of the present application. As Figure 1 shown, the reagent mixing system includes: a central ring 101, a carrier plate 102, and a first reagent bottle 103. The carrier plate 102 surrounds the outside of the central ring 101 and rotates relative to the central ring 101. The first reagent bottle 103 is torsionally fixed on the carrier plate 102. An action part 104 is provided on the first reagent bottle 103, and a trigger part 105 is correspondingly provided on the central ring 101. The action part 104 and the trigger part 105 are respectively located on the sides of the first reagent bottle 103 and the central ring 101 facing each other. When the carrier plate 102 rotates to the corresponding positions of the action part 104 and the trigger part 105, the trigger part 105 contacts the action part 104 and causes the first reagent bottle 103 to twist around its fixed position on the carrier plate 102. In some embodiments, optionally, the action part 104 can be directly provided on the first reagent bottle 103. In other embodiments, the action part 104 is connected to the first reagent bottle 103 through other structures, that is, the action part 104 can be indirectly provided on the first reagent bottle 103. In some embodiments, optionally, the first reagent bottle is a magnetic bead bottle with magnetic bead particles inside. Under the action of the action part and the trigger part, it is mixed evenly inside the first reagent bottle.

[0037] Among them, the first reagent bottle 103 on the carrier plate 102 rotates around the central ring 101 as the carrier plate 102 rotates. A plurality of trigger parts 105 are arranged at intervals along the circumferential direction on the side surface of the central ring 101. The action part 104 provided on the first reagent bottle follows the first reagent bottle 103 on the carrier plate 102 to rotate to the position corresponding to the trigger part 105 on the central ring 101, and the action part 104 contacts the trigger part 105. Since the carrier plate 102 is still rotating, the action part 104 drives the first reagent bottle 103 to rotate under the restriction of the trigger part 105. When the action part 104 rotates to the position tangent to the rotation direction of the carrier plate 102, the action part leaves the trigger part. In some embodiments, optionally, an elastic element is provided between the first reagent bottle and the carrier plate, and the first reagent bottle can rotate on the carrier plate. When the action part leaves the trigger part, the first reagent bottle shakes under the action of the elastic force of the elastic element until it stops or contacts the next trigger part.

[0038] In some embodiments, optionally, the carrier plate rotates driven by a power mechanism, and then drives the first reagent bottle to rotate around the central ring.

[0039] By providing the action part and the trigger part and using the contact and collision between the trigger part and the action part to complete the mixing of the reagent in the first reagent bottle, the reagent mixing system provided by the embodiments of the present application has a simple and compact structure and can complete the mixing of the reagent without many power structures. In addition, since the movement is transmitted by the contact between the action part and the trigger part, the force borne by the action part will cause an acceleration in the movement of the first reagent bottle. Therefore, compared with other uniform mixing technologies, the variable-speed mixing technology has greater advantages in mixing the reagent.

[0040] Continue to refer to Figure 1 As shown, a plurality of mixing bases 106 are provided at intervals along the circumferential direction on the carrier plate 102. The mixing bases 106 are used to torsionally fix the first reagent bottle 103 on the carrier plate 102. In some embodiments, optionally, the carrier plate 102 does not need to be provided with mixing bases. The carrier plate can be directly connected to the first reagent bottle 103 through an elastic element. The carrier plate 103 is provided with a concave structure, and the bottom of the first reagent bottle has a convex structure. The convex structure passes through the elastic element and sinks into the concave structure, so as to realize the torsionally fixed connection between the first reagent bottle and the carrier plate. Another situation can be that the carrier plate 102 is connected to the first reagent bottle 103 through the mixing base 106. The mixing bases 106 are arranged on the carrier plate 102 along the circumferential direction, and a plurality of first reagent bottles 103 are torsionally fixed on the carrier plate 102, and the contact between the action part 104 and the trigger part 105 is used to perform the mixing work of the reagent.

[0041] Figure 2 It is a schematic structural diagram of a mixing base of a reagent mixing system provided by an embodiment of the present application. Combining Figure 1 with Figure 2 As shown, the mixing base 106 includes a bottom support 1061 and an elastic element 1062. Among them, one end of the elastic element 1062 is fixedly connected to the carrier plate 102, and the other end is connected to the bottom support 1061. In Figure 2 the embodiment shown, the elastic element 1062 is a torsion spring. Under the alternating action of the torsional force and the elastic restoring force of the torsion spring, the bottom support can reciprocally rotate. The bottom support 1061 is arranged above the elastic element 1062 and is connected to the bottom of the first reagent bottle 103. The action part 104 is arranged on the side of the bottom support 1061, and the bottom support 1061 is used to transmit the rotational movement to the first reagent bottle 103.

[0042] In some examples, optionally, the action part 104 may be provided with fixing holes. The elastic element 1062 is made of a metal material. One end of the elastic element 1062 may pass through and be fixed in the positioning hole. The carrier plate 102 is also provided with fixing holes. The other end of the elastic element 1062 passes through this positioning hole and is fixed on the carrier plate 102. The bottom of the first reagent bottle is connected to the inside of the bottom bracket. Driven by the bottom bracket, the first reagent bottle can rotate.

[0043] An elastic element and a bottom bracket are arranged in the mixing base, so that the first reagent bottle can rotate stably on the carrier plate. Moreover, since the elastic element is connected to the bottom bracket, the first reagent bottle can be conveniently taken out from the carrier plate without excessive requirements on the structure of the first reagent bottle. The elastic element can also cause the first reagent bottle to rotate reciprocally. Since it is not a uniform rotation, the mixing of the reagent in the first reagent bottle becomes more uniform, and to a certain extent, the occurrence of wall hanging phenomenon can be reduced.

[0044] As Figure 2 shown, the mixing base further includes a bottom bracket ring 1063. The bottom bracket ring 1063 is fixed on the carrier plate 102. A first groove 201 is provided inside the bottom bracket ring; a protrusion 202 is provided at a position corresponding to the first groove 201 below the bottom bracket. The protrusion 202 is rotatably connected to the first groove 201. Among them, the first groove 201 is provided at the center position of the bottom bracket ring and has a certain depth. The protrusion 202 is provided at the center position of the bottom bracket and corresponds to the position of the first groove 201. The protrusion 202 can be inserted into the first groove 201. When the action part drives the bottom bracket to rotate, the protrusion 202 rotates in the first groove 201. In addition, the protrusion 202 inserted in the first groove can limit the position of the bottom bracket 1061 to prevent it from deviating too far from the original position when the bottom bracket rotates, affecting the next contact between the action part and the trigger part.

[0045] In some embodiments, in order to reduce the friction between the action part and the trigger part, the collision part between the trigger part and the action part is made of an elastic material. In this way, when the trigger part contacts and presses the action part, the friction between the two can be reduced by deformation, so as to prevent wear problems caused by frequent contact between the two. When the wear is serious, it will affect the contact duration between the action part and the trigger part, and may further affect the mixing strength or speed of the first reagent bottle.

[0046] Combined Figure 1 with Figure 2As shown, in some embodiments, optionally, the actuating portion 104 is the first arc-shaped lug 208, and the triggering portion 105 is the ball plunger 107. A first positioning hole 204 is formed in the first arc-shaped lug 208, a second positioning hole 206 is formed in the carrier plate 102, and the elastic element 1062 is a torsion spring 207. One end of the torsion spring 207 is fixed in the first positioning hole 204 on the bottom support ring, and the other end is fixed in the second positioning hole 206 on the carrier plate. When the carrier plate 102 rotates to make the ball plunger 107 abut against the first arc-shaped lug 208, the torsion spring 207 is torsionally deformed, causing the first reagent bottle 103 to rotate relative to the carrier plate 102. Since the torsion spring needs to release elastic potential energy after deformation, when the first arc-shaped lug leaves the ball plunger, it will continue to shake for a period of time. In addition, using the torsion spring to drive the rotation of the first reagent bottle will cause the first reagent bottle to perform variable-speed motion, and the power generated after the torsion spring is deformed is relatively large, enabling the first reagent bottle to rotate violently, and the reagent in the first reagent bottle can be evenly mixed. In addition, the rotation speed of the carrier plate and the switching frequency of the forward and reverse directions can be adjusted by adjusting the transmission mechanism to flexibly achieve various mixing effects of the reagent.

[0047] A spring can be arranged inside the ball plunger 107. When the first arc-shaped lug 208 comes into contact with the ball plunger 107, elastic deformation can occur, which can not only reduce wear but also cause the first reagent bottle 103 to rotate while triggering the torsion of the mixing base 106.

[0048] Figure 3 It is a schematic structural diagram of the actuating portion and the triggering portion in another reagent mixing system provided by an embodiment of the present application. Corresponding Figure 2 The actuating portion 104 in the embodiment shown is the first triangular protrusion 301 as shown in Figure 3 In the embodiment shown, and the triggering portion 105 in the embodiment shown in Figure 2 is the cylindrical protrusion 302 in the embodiment shown in Figure 3 And a spring is arranged inside the cylindrical protrusion 302. The first triangular protrusion 301 is arranged on the bottom support 1061. A first positioning hole 204 is arranged on the first triangular protrusion 301, a second positioning hole 206 is arranged on the carrier plate 102, and the elastic element 1062 is a torsion spring 207. One end of the torsion spring 207 is fixed in the first positioning hole 204, and the other end is fixed in the second positioning hole 206. When the carrier plate rotates to make the first triangular protrusion abut against the cylindrical protrusion, the torsion spring is torsionally deformed, causing the first reagent bottle to rotate relative to the carrier plate.

[0049] Figure 4 It is a schematic structural diagram of the actuating portion and the triggering portion in yet another reagent mixing system provided by an embodiment of the present application. Corresponding Figure 2 The actuating portion 104 in the embodiment shown is as shown inFigure 4 In the illustrated embodiment, it is the second triangular protrusion 401, corresponding to Figure 2 In the illustrated embodiment, the triggering part 105 in Figure 4 In the illustrated embodiment, it is the second arc lug 402, and a spring is provided inside the second arc lug 402. The second triangular protrusion 401 is arranged on the base 1061, a first positioning hole 204 is arranged on the second triangular protrusion 401, a second positioning hole 206 is arranged on the carrier plate 102, the elastic element 1062 is a torsion spring 207, one end of the torsion spring 207 is fixed in the first positioning hole 204, and the other end is fixed in the second positioning hole 206. When the carrier plate rotates, the second triangular protrusion abuts against the second arc lug, and the torsion spring is torsionally deformed, so that the first reagent bottle rotates relative to the carrier plate.

[0050] Continue to refer to Figure 2 As shown, transmission parts are correspondingly arranged on the first reagent bottle and the inner side of the base, so that the first reagent bottle 103 and the base 1061 rotate in the same direction. The transmission part on the first reagent bottle cooperates with the transmission part inside the base, so that the first reagent bottle can rotate driven by the base. The transmission part can stabilize the first reagent bottle in the base and transmit the movement of the base to the first reagent bottle. In some embodiments, optionally, the transmission part includes: a second groove 2031 arranged on the side of the first reagent bottle along the axial direction and a triangular convex rib 2032 arranged on the inner side of the base. The triangular convex rib 2032 is embedded in the second groove 2031. When the base 1061 rotates, it drives the first reagent bottle 103 to rotate.

[0051] Continue to refer to Figure 2 As shown, the transmission part 203 includes: a second groove 2031 arranged on the side of the first reagent bottle along the axial direction and a triangular convex rib 2032 arranged on the inner side of the base. The triangular convex rib 2032 is embedded in the second groove 2031. When the base 1061 rotates, it drives the first reagent bottle 103 to rotate. The second groove 2031 has a certain length along the axial direction. The second groove 2031 cooperates with the triangular convex rib 2032, so that the base 1061 can drive the first reagent bottle 103 to rotate.

[0052] Figure 5 It is a schematic structural diagram of another transmission part proposed in the embodiment of the present application. As Figure 5 shown, the transmission part includes a claw 501 arranged at the bottom of the first reagent bottle 103 and a convex tooth 502 arranged on the inner side of the base 1061. The claw 501 meshes with the convex tooth 502. When the base 1061 rotates, it drives the first reagent bottle 103 to rotate. The claw 501 is stuck into the groove between the convex teeth 502. When the base 1061 rotates, the movement is transmitted to the first reagent bottle 103 through the meshing of the claw 501 and the convex tooth 502.

[0053] Figure 6 This is another structural schematic diagram of the transmission part proposed in the embodiments of the present application. As Figure 6 shown, the transmission part includes: an arc-shaped convex strip 602 arranged along the axial direction on the side of the first reagent bottle 103 and a toothed convex rib 601 arranged inside the bottom tray 1061. The arc-shaped convex strip 602 meshes with the toothed convex rib 601. When the bottom tray 1061 rotates, it drives the first reagent bottle 103 to rotate. The arc-shaped convex strip 602 meshes with the toothed convex rib 601 inside the bottom tray 1061, enabling the bottom tray 1061 to transmit the motion to the first reagent bottle 103. In some embodiments, optionally, the arc-shaped convex strip 602 can be made of an elastic material to facilitate the insertion and removal of the first reagent bottle 103.

[0054] Figure 7 This is another partial structural schematic diagram of the reagent mixing system provided according to the embodiments of the present application. As Figure 7 shown, the mixing system further includes: a positioning disk 701. The positioning disk 701 is arranged above the central ring 101 and is connected to the carrier disk 102. Mixing positioning slots 702 are provided at the corresponding positions of the positioning disk 701 and the mixing base 106. The positioning disk 701 is connected to a power mechanism 703. The power mechanism 703 drives the positioning disk 701 to rotate, and the positioning disk 701 drives the carrier disk to move around the central ring. In some embodiments, optionally, the mixing positioning slot 702 only includes a positioning hole 704, and the first reagent bottle 103 can be directly inserted into the positioning hole 704. The positioning hole can enable the first reagent bottle to rotate stably on the carrier disk without affecting the mixing motion of other first reagent bottles. That is, the first reagent bottle can be placed in the mixing positioning slot, and the mixing positioning slot is used to restrict the movement of the first reagent bottle in the circumferential direction.

[0055] Combined with Figure 2 and Figure 7 shown, the reagent mixing system further includes: a reagent kit 705, and the reagent kit 705 is placed in the mixing positioning slot 702. The reagent kit 705 is used to carry the first reagent bottle 103, the second reagent bottle 705, and the third reagent bottle 706. It should be noted that, in some embodiments, the second reagent bottle 705 and the third reagent bottle 706 are integrated with the reagent kit body. The first reagent bottle 103 is located in the perforation 209 of the reagent kit, and the first reagent bottle 103 can rotate in the perforation 209.

[0056] Figure 8 This is a cross-sectional view of the structure of a reagent kit proposed according to the embodiments of the present application. As Figure 8As shown, in order to prevent the first reagent bottle 103 from moving up and down, the diameter of the first reagent bottle 103 in the axial direction from the bottle mouth to the bottle bottom decreases, and the side of the first reagent bottle 103 is provided with a one-way chamfer 801, which is used to limit the movement of the first reagent bottle in the axial direction. The first reagent bottle 103 itself has a certain taper, and the one-way chamfer 801 can ensure that the first reagent bottle 103 easily penetrates the perforation 209 of the reagent box from top to bottom, but can ensure that the first reagent bottle 103 will not be reversed from the inside of the perforation 209. It is ensured that the first reagent bottle 103 will not move up and down in the reagent box 705. In some examples, optionally, an annular structure is provided on the side of the first reagent bottle, and the bottom of the annular structure is provided with a chamfer, and the upper part of the annular structure is a plane, that is, a one-way chamfer. When the first reagent bottle passes through the perforation, it is squeezed with the bottom chamfer and can enter the perforation. However, due to the particularity of the one-way chamfer, the upper part of the annular structure is a plane that is stuck at the exit below the perforation, making it impossible for the first reagent bottle to escape from the perforation of the reagent kit to a certain extent.

[0057] By providing the first reagent bottles with different diameters and one-way chamfers, it is possible to prevent the first reagent bottles from running around when they are rotated.

[0058] Continue to see Figure 7 As shown, the card tray 701 is marked with a symbol 708. The symbol 708 is marked on a circular cover 709 protruding from the center of the card tray. The position of the symbol corresponds to the position of the mixing card, and the symbol is used to mark the position of the mixing card. In some embodiments, optionally, the symbol is an Arabic numeral, and its position is consistent with the position of the mixing card, which is used to mark the position of the mixing card.

[0059] Figure 9 FIG. 1 is a schematic diagram of another reagent mixing system structure proposed according to an embodiment of the present application. Figure 9 As shown, the mixing system further includes: a chamber body 901 and a chamber cover 902. The center ring and the carrier plate are arranged in the chamber body 901, and the chamber cover 902 is arranged above the chamber body. The chamber cover 902 and the chamber body 901 cooperate to prevent the environment in the reagent mixing system from being polluted.

[0060] In some embodiments, optionally, the storage cover 902 includes a first storage cover 9021 and a second storage cover 9022. The second storage cover 9022 is connected to the storage body 901, and a reagent outlet 907 corresponding to the mixing position 702 is provided on the second storage cover 9022. The reagent outlet 907 is used as the outlet when the reagent in the reagent bottle is aspirated by the reagent needle. The second storage cover 9022 is movably connected to the first storage cover 9021. The center of the first storage cover 9021 is offset from the center of the circle of the second storage cover 9022 by a preset distance, and the first storage cover 9021 is arranged above the mixing position. When it is necessary to replace the reagent kit in the reagent storage, only the first storage cover 9021 needs to be opened for replacement. In this way, it can be ensured that the environment of the storage body will not be in large-area contact with the external environment, preventing the external environment from polluting the inside of the system.

[0061] Continue to refer to Figure 9 As shown, a sensor 903 is provided on the second storage cover 9022, and a signal transmitter is provided at the corresponding position of the first storage cover 9021 and the sensor 903. The sensor 903 is used to sense the placement state of the first storage cover 9021. By setting the sensor, it can be determined whether the first storage cover is accurately placed above the second storage cover, and the sensor can also emit signals and prompt the staff. In some embodiments, optionally, the sensor is a Hall sensor and the signal transmitter is a magnetic element.

[0062] The system mixing system further includes a barcode scanner 904. The barcode scanner 904 is provided outside the storage body 901 and is used to scan and read the information of the reagent kit. A label is provided on the reagent kit, and the scanner can read information such as the type of reagent in the reagent kit by scanning the label on the reagent kit.

[0063] As Figure 9 shown, the reagent mixing system further includes a refrigeration unit 905. The refrigeration unit 905 is arranged below the storage body 901 and is used to keep the temperature of the storage body 901 within a preset range. The refrigeration function of the refrigeration unit can ensure that the temperature in the storage body is kept within the preset range. Usually, the temperature in the reagent storage needs to be lower than the indoor temperature to ensure the activity of some important components in the reagent.

[0064] In addition, the reagent mixing system further includes an air duct 906. The air duct 906 includes a fan 9061 and a baffle 9062. The baffle 9062 encloses a channel. The channel is arranged below the refrigeration unit 905, and the fan 9061 is arranged at the outlet of the channel and is used to discharge the heat generated by the refrigeration unit.

[0065] Figure 10 is Figure 9 a partial structural cross-sectional view. As Figure 10As shown in the figure, the reagent mixing system includes a transmission mechanism, a reagent kit 705, and a first reagent bottle 103, a second reagent bottle 706, and a third reagent bottle 707, a central ring 101, a carrier plate 102, a housing 901, a baffle, etc. accommodated therein. Among them, the transmission mechanism includes: a motor 1001, a small pulley 1002, a belt 1003, a large pulley 1004, a rotating sleeve 1005, and a shaft system 1006. The power of the motor 1001 is transmitted to the carrier plate 102 through the small pulley 1002, the belt 1003, the large pulley 1004, the shaft system 1006, and the rotating sleeve 1005. The shaft system 1006 is fixed on the baffle 9062. The shaft system 1006 can not only support the rotating sleeve 1005 but also enable the rotating sleeve 1005 to rotate around itself. The carrier plate 102 is installed on the rotating sleeve 1005 and can rotate driven by the rotating sleeve 1005. The reagent kit 705 is placed on the carrier plate 102 through a clamping disk 701, and the reagent kit 705 is driven to rotate by the rotation of the motor 1001. The refrigeration chamber 1007 and the heat preservation cover 1008 are both part of the housing 901. Among them, the refrigeration chamber 1007 is fixed on the baffle 9062 through an adiabatic support 1009, and the central ring 101 is installed on the refrigeration chamber 1007, so as to ensure that the central ring 101 remains stationary relative to the ground. The heat preservation cover 1008 wraps around the outer surface of the refrigeration chamber 1007 to play a heat preservation role.

[0066] The present application also provides a chemiluminescence immunoassay analyzer, which includes an incubation disk and also includes the reagent mixing system as described in any one of the foregoing items. The reagent mixing system is used to provide the mixed reagent to the reaction tubes located in the incubation disk.

[0067] In summary, the reagent mixing system provided by the embodiments of the present application has a simple and compact structure. By using the contact between the action part and the trigger part, the first reagent bottle is rotated, so that the reagent in the first reagent bottle is mixed evenly. The force exerted by the trigger part on the action part causes the first reagent bottle to perform a variable-speed motion, and because of the appearance of acceleration, the mixing degree of the reagent in the first reagent bottle can be increased. To a certain extent, the phenomenon of wall hanging can also be prevented. In addition, the chemiluminescence immunoassay analyzer provided with the reagent mixing system proposed in the embodiments of the present application can provide a more evenly mixed reagent to the test tubes in the incubation disk.

[0068] The above embodiments are only for explaining the present invention and are not intended to limit the present invention. Those of ordinary skill in the relevant technical fields can make various changes and modifications without departing from the scope of the present invention. Therefore, all equivalent technical solutions should also fall within the scope of the disclosure of the present invention.

Claims

1. A reagent mixing system, comprising: a central ring, a carrier plate, and a first reagent bottle. The carrier plate surrounds the outside of the central ring and rotates relative to the central ring. It is characterized in that the first reagent bottle can be torsionally fixed on the carrier plate. An action part is provided on the first reagent bottle, and a trigger part is correspondingly provided on the central ring. The action part and the trigger part are respectively located on the sides of the first reagent bottle and the central ring facing each other. When the carrier plate rotates to the corresponding positions of the action part and the trigger part, the trigger part contacts the action part and causes the first reagent bottle to twist around its fixed position on the carrier plate; wherein, a plurality of mixing bases are provided at intervals along the circumferential direction on the carrier plate, and the mixing bases are used to torsionally fix the first reagent bottle on the carrier plate; an elastic element is provided between the first reagent bottle and the carrier plate. When the action part leaves the trigger part, the first reagent bottle shakes under the action of the elastic force of the elastic element until it stops or contacts the next trigger part.

2. The reagent mixing system according to claim 1, characterized in that, the mixing base includes a bottom support, an elastic element, and a bottom support ring, wherein, one end of the elastic element is fixedly connected to the carrier plate, and the other end is connected to the bottom support. The elastic element is used to make the bottom support rotate reciprocally; the bottom support is arranged above the elastic element and is connected to the bottom of the first reagent bottle. The action part is arranged on the side of the bottom support, and the bottom support is used to transmit the rotational movement to the first reagent bottle; the bottom support ring is fixed on the carrier plate, and a first groove is provided in the bottom support ring; a protrusion is provided at a position corresponding to the first groove below the bottom support, and the protrusion is rotatably connected to the first groove.

3. The reagent mixing system according to claim 1, characterized in that, the collision part of the trigger part and the action part is made of an elastic material.

4. The reagent mixing system according to claim 2, characterized in that, the action part is a first arc-shaped lug, and the trigger part is a ball plunger; a first positioning hole is provided on the first arc-shaped lug, and a second positioning hole is provided on the carrier plate. The elastic element is a torsion spring. One end of the torsion spring is fixed in the first positioning hole, and the other end is fixed in the second positioning hole; when the carrier plate rotates to make the ball plunger abut against the first arc-shaped lug, the torsion spring is torsionally deformed, so that the first reagent bottle rotates relative to the carrier plate.

5. The reagent mixing system according to claim 2, characterized in that, the action part is a first triangular protrusion, and the trigger part is a cylindrical protrusion, and a spring is provided inside the cylindrical protrusion; or, the action part is a second triangular protrusion, and the trigger part is a second arc-shaped lug, and a spring is provided inside the arc-shaped lug.

6. The reagent mixing system according to claim 2, characterized in that, transmission parts are correspondingly provided on the first reagent bottle and the inner side of the bottom support, so that the first reagent bottle and the bottom support rotate in the same direction.

7. The reagent mixing system according to claim 6, wherein, the transmission part includes: a second groove arranged along the axial direction on the side surface of the first reagent bottle and a triangular convex rib arranged on the inner side of the bottom tray; the triangular convex rib is embedded in the second groove, and when the bottom tray rotates, it drives the first reagent bottle to rotate; or, the transmission part includes: a claw arranged at the bottom of the first reagent bottle and a convex tooth arranged on the inner side of the bottom tray; the claw meshes with the convex tooth, and when the bottom tray rotates, it drives the first reagent bottle to rotate; or the transmission part includes: an arc-shaped convex strip arranged along the axial direction on the side surface of the first reagent bottle and an arc-shaped convex rib arranged on the inner side of the bottom tray; the arc-shaped convex strip meshes with the arc-shaped convex rib, and when the bottom tray rotates, it drives the first reagent bottle to rotate.

8. The reagent mixing system according to claim 1, wherein, the mixing system further includes: a positioning disk, the positioning disk is arranged above the central ring and is connected to the bearing disk, and mixing positionings are provided at corresponding positions of the positioning disk and the mixing base.

9. The reagent mixing system according to claim 8, wherein, the first reagent bottle is placed in the mixing positioning, and the mixing positioning is used to limit the movement of the first reagent bottle in the circumferential direction.

10. The reagent mixing system according to claim 8, wherein, the mixing system further includes: a reagent kit, the reagent kit is located in the mixing positioning, and the reagent kit is used to carry the first reagent bottle, the second reagent bottle and the third reagent bottle.

11. The reagent mixing system according to claim 10, wherein, the diameter of the first reagent bottle decreases in the axial direction from the bottle mouth to the bottle bottom, and a one-way chamfer is provided on the side surface of the first reagent bottle to limit the movement of the first reagent bottle in the axial direction.

12. The reagent mixing system according to claim 9 or 10, wherein, symbols are marked on the positioning disk, and the positions of the symbols correspond one-to-one with the positions of the mixing positionings, and the symbols are used to mark the positions of the mixing positionings.

13. The reagent mixing system according to claim 12, wherein, the mixing system further includes: a housing and a housing cover, the central ring and the bearing disk are arranged in the housing, and the housing cover is arranged above the housing.

14. The reagent mixing system according to claim 13, wherein, the housing cover includes a first housing cover and a second housing cover, the second housing cover is connected to the housing, and a reagent outlet corresponding to the mixing positioning is provided on the second housing cover, and the reagent outlet is used as an outlet when the reagent in the reagent bottle is sucked by a reagent needle; the first housing cover is movably connected to the second housing cover, and the center of the first housing cover deviates from the center of the second housing cover by a preset distance.

15. The reagent mixing system according to claim 14, wherein, A sensor is provided on the second lid, and a signal transmitter is provided at a position corresponding to the sensor on the first lid. The sensor is used to sense the placement state of the first lid. Among them, the sensor is a Hall sensor, and the signal transmitter is a magnetic element.

16. The reagent mixing system according to claim 13, characterized in that, the system further includes a barcode scanner provided outside the chamber body for scanning and reading the information of the reagent kit.

17. The reagent mixing system according to claim 13, characterized in that, the system further includes: a refrigeration unit provided below the chamber body for maintaining the temperature of the chamber body within a preset range; an air duct including a fan and a baffle. The baffle surrounds to form a channel. The channel is provided below the refrigeration unit. The fan is provided at the outlet of the channel for discharging the heat generated by the refrigeration unit.

18. A chemiluminescence immunoassay analyzer includes an incubation disc, characterized in that, it further includes the reagent mixing system according to any one of claims 1-17. The reagent mixing system is used to provide the mixed reagent to the reaction tube located in the incubation disc.

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