Liquid path system for chemiluminescent immunoassay analyzer

Abstract

The utility model discloses a liquid path system for chemiluminescence immunoassay analyzer, including magnetic bead cleaning unit, substrate adds unit, water unit and waste liquid unit, sample adds unit, reagent adds unit, washing liquid proportioning unit, water unit includes water supply pipeline, and the purified water container and water pipeline are connected with water supply pipeline, and the first pressure regulating valve, first valve and first pump are set gradually on water supply pipeline. The water unit of utility model discloses can realize the automatic supply of purified water, and the water unit provides purified water for sample adds unit, reagent adds unit, washing liquid proportioning unit, magnetic bead cleaning unit, ensures the cleaning effect of pipeline and the automatic preparation of washing liquid, guarantees continuous detection, in addition, the washing liquid container of utility model has two or two or more and is connected with each other, can realize automatic proportioning and timely supply washing liquid, ensures the normal operation of magnetic bead cleaning operation, improves the detection efficiency, furthermore, sample adds unit and reagent adds unit are independent of each other, improve the processing efficiency of sample.

Description

Technical Field

[0001] This utility model relates to the field of liquid circuits in in vitro diagnostic equipment, and in particular to a liquid circuit system for an immunoassay analyzer. Background Technology

[0002] In recent years, the number of samples tested in major hospitals and testing centers has increased rapidly. Furthermore, the environmentally friendly, fast, and accurate characteristics of fully automated chemiluminescence analyzers have driven their development towards high speed and high precision. The liquid path system of a chemiluminescence immunoassay analyzer is the core execution module ensuring accurate quantitative analysis, stable operation, and repeatable testing. Currently, the liquid path system uses a single system for reagent and sample loading, resulting in low sample loading efficiency (including both sample and reagent processing) and impacting testing efficiency. Additionally, the liquid path system requires manual replenishment of purified water or washing solution during operation, during which the instrument is paused, further affecting testing efficiency. Moreover, the waste liquid treatment rate of existing liquid path systems is slow, failing to meet the rapid testing requirements of high-throughput instruments. Summary of the Invention

[0003] In view of this, the present invention proposes a liquid circuit system for a chemiluminescence immunoassay analyzer.

[0004] To achieve the above objectives, the present invention adopts the following technical solution:

[0005] The liquid circuit system for a chemiluminescence immunoassay analyzer described in this utility model includes a magnetic bead cleaning unit, a substrate dispensing unit, a water supply unit, and a waste liquid discharge unit. It also includes a sample dispensing unit, a reagent dispensing unit, and a washing solution mixing unit. The water supply unit includes a water supply pipeline, a purified water container connected to the water supply pipeline, and a water supply line. A first pressure regulating valve, a first valve, and a first pump are sequentially arranged on the water supply pipeline. The water supply line has at least two lines. The outlet of the second pump of each water supply line is split into two: one line is connected to a water distributor, and the other line has a second pressure regulating valve and flows back into the purified water container.

[0006] The washing solution mixing unit includes a first washing solution container, a second washing solution container, and at least two concentrated solution containers for holding concentrated washing solution. The first washing solution container is connected to the purified water container via a pure water pipeline, and a third pump is installed on the pure water pipeline. At least two of the concentrated solution containers are connected to the inlet of the concentrated pump, and the outlet of the concentrated pump is connected to the first washing solution container. The first washing solution container and the second washing solution container are connected via a washing solution pipeline, and a fourth pump is installed on the washing solution pipeline. A liquid level monitoring device for monitoring the liquid level is installed below or inside the first and second washing solution containers.

[0007] The beneficial effects are as follows: The water supply unit of this invention enables automatic replenishment of purified water. It provides purified water to the sample dispensing unit, reagent dispensing unit, washing solution mixing unit, and magnetic bead cleaning unit, ensuring effective cleaning of the pipelines and automatic preparation of the washing solution without manual replenishment, thus ensuring continuous instrument detection. Furthermore, the washing solution containers of this invention are two or more and interconnected, enabling automatic mixing and timely replenishment of the washing solution, ensuring the normal operation of the magnetic bead cleaning process without manual replenishment, thereby improving detection efficiency. Moreover, the sample dispensing unit and reagent dispensing unit of this invention are independent of each other, improving sample processing efficiency.

[0008] The magnetic bead cleaning unit includes a cleaning solution filling module and a cleaning solution suction module. The cleaning solution filling module is equipped with a first two-position three-way valve at the main cleaning solution pipeline. The inlet of the first two-position three-way valve is divided into two paths, one of which is connected to the second cleaning solution container and the other of which is connected to the water distributor.

[0009] The washing liquid filling module has multiple filling branches connected to the main washing liquid pipeline. Each filling branch includes a filling branch pipe, a second valve, a filling pump, and a third valve arranged sequentially on the filling branch pipe. The third valve is a two-position three-way valve. One port of each third valve is connected to the washing liquid discharge pipe. The outlet of the washing liquid discharge pipe is connected to the waste liquid container of the waste liquid unit, and the washing liquid discharge pipe has a fourth valve.

[0010] Preferably, the waste liquid unit includes a first waste discharge unit and a second waste discharge unit, wherein the second waste discharge unit has a waste liquid container and a second discharge pump connected to the waste liquid container;

[0011] The first waste discharge unit is a vacuum waste liquid discharge unit, which has a vacuum pump, a first negative pressure tank and at least two second negative pressure tanks. The vacuum pump is connected to the first negative pressure tank. The connecting pipeline between the first negative pressure tank and each of the second negative pressure tanks is equipped with a pressure regulating valve and a fifth valve for adjusting the pressure. Each second negative pressure tank is connected to a balance pipe that communicates with the outside atmosphere. A sixth valve is provided on the balance pipe.

[0012] The sample needle cleaning pool of the sample dispensing unit and the reagent needle cleaning pool of the reagent dispensing unit are connected to each second negative pressure tank via waste liquid pipelines; the lower part of the first negative pressure tank and each second negative pressure tank is connected to a waste discharge branch, which is connected to the first discharge pump, and each waste discharge branch is equipped with a seventh valve.

[0013] The beneficial effects are: the waste liquid unit of this utility model has a first waste discharge unit and a second waste discharge unit. The second waste discharge unit uses a pump to draw the waste liquid into the waste liquid container, and the first waste discharge unit is a vacuum waste discharge unit. The combination of the two improves the waste liquid discharge efficiency, thereby improving the operating speed of this utility model and meeting the needs of high-throughput instruments.

[0014] The sample dispensing unit includes a sample dispensing module and a sample needle cleaning module. The sample needle cleaning module includes an alkaline solution container and an alkaline washing pipeline connected to the alkaline solution container. The alkaline washing pipeline is connected to the sample needle cleaning tank, and an alkaline washing pump is installed on the alkaline washing pipeline. A third drain pump is connected to the bottom of the sample needle cleaning tank via a pipeline, and the third drain pump is connected to the waste liquid container. The beneficial effect is that this invention adds alkaline washing to the sample needles of the sample dispensing unit, ensuring the cleaning effect of the sample needles.

[0015] Preferably, the liquid circuit system for a chemiluminescence immunoassay analyzer according to this invention further includes a liquid aspiration unit. The liquid aspiration unit comprises a liquid aspiration needle and a liquid aspiration pump connected in sequence via tubing. The outlet of the liquid aspiration pump is connected to the waste liquid container. In this invention, the combination of the liquid aspiration needle and the liquid aspiration pump allows the reacted liquid to be directly pumped into the waste liquid container, which is beneficial for subsequent magnetic bead cleaning.

[0016] Preferably, each suction branch of the washing liquid suction module is connected to the waste liquid container. During the cleaning process, the washing liquid suction module directly pumps the cleaned waste liquid into the waste liquid container, achieving rapid waste discharge.

[0017] Preferably, the substrate dispensing unit has a first substrate container and a second substrate container, wherein there are at least two first substrate containers and at least two second substrate containers. In this invention, each type of substrate corresponds to at least two substrate containers, which can be used alternately to improve detection efficiency.

[0018] Compared with the prior art, the advantages of this utility model are:

[0019] The water supply unit of this invention enables automatic replenishment of purified water. It provides purified water to the sample dispensing unit, reagent dispensing unit, washing solution preparation unit, and magnetic bead cleaning unit, ensuring effective cleaning of the tubing and automatic preparation of the washing solution without manual replenishment, thus ensuring continuous instrument detection. Furthermore, the washing solution containers of this invention are arranged in two or more interconnected units, enabling automatic mixing and timely replenishment of the washing solution, ensuring the normal operation of the magnetic bead cleaning process without manual replenishment, thereby improving detection efficiency. Moreover, the sample dispensing unit and reagent dispensing unit of this invention are independent of each other, improving sample processing efficiency. Attached Figure Description

[0020] Figure 1 This is a schematic diagram of the present invention.

[0021] Figure 2 This is a schematic diagram of the substrate dispensing unit described in this utility model.

[0022] Figure 3This is a schematic diagram of the automatic proportioning unit and the magnetic bead cleaning unit described in this utility model.

[0023] Figure 4 This is a schematic diagram of the waste liquid discharge unit described in this utility model. Detailed Implementation

[0024] The embodiments of this utility model will be described in detail below with reference to the accompanying drawings. These embodiments are implemented based on the technical solution of this utility model and provide detailed implementation methods and specific operation processes. However, the protection scope of this utility model is not limited to the following embodiments.

[0025] It should be noted that in the description of this utility model, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations.

[0026] In the description of this utility model, unless otherwise explicitly specified and limited, the terms "connected" and "linked" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0027] like Figure 1-4 As shown, this utility model proposes a liquid circuit system for a chemiluminescence immunoassay analyzer, including a magnetic bead cleaning unit, a substrate dispensing unit, a water supply unit, and a waste liquid discharge unit. It also includes a sample dispensing unit, a reagent dispensing unit, and a washing solution mixing unit. The water supply unit includes a water supply pipeline, a purified water container 104 connected to the water supply pipeline, and the water supply pipeline itself. A first pressure regulating valve 101, a first valve 102, and a first pump 103 are sequentially installed on the water supply pipeline. The first pump 103 provides power to the purified water, allowing it to enter the purified water container 104. A weight sensor 105 is located below the purified water container 104 to monitor its weight. When the weight is less than a set value, the first pump 103 and the first valve 102 automatically replenish water to meet the instrument's continuous detection requirements. The water supply unit can be connected to an external purified water device to achieve automatic replenishment of the purified water container 104, meeting the water needs of the sample needle 204, reagent needle, magnetic bead cleaning module, and washing solution mixing unit. During operation, the water supply pressure is adjusted by the first pressure regulating valve 101, and the first valve 102 and the first pump 103 are opened to supply water until the water in the purified water container 104 reaches the upper limit. Then the first valve 102 and the first pump 103 are closed to stop the water supply.

[0028] The water supply unit has two water supply pipelines and a water distributor 109. Each water supply pipeline has a second pump 106. The inlet end of the second pump 106 extends into the purified water container 104. The outlet end of the second pump 106 is split into two: one path connects to the water distributor 109, and the other path flows back to the purified water container 104 via a second pressure regulating valve 107. The pressure can be regulated by the second pressure regulating valve 107 to adjust the pressure at each inlet of the water distributor 109. Each inlet of the water distributor 109 has a first pressure sensor 108. When the pressure is too high, the flow can be diverted through the second pressure regulating valve 107.

[0029] The tubing of the sample dispensing unit is the same as that of the reagent dispensing unit. Taking the sample dispensing unit as an example, it includes a sample dispensing module and a sample needle cleaning module. The sample dispensing module includes a sample needle 204 and a sample dispensing pump 203, which are connected by tubing. The sample needle cleaning module includes a sample needle cleaning tank 302 and a sample needle cleaning tubing. The sample dispensing pump 203 is connected to the water separator 109 through a sample needle cleaning tubing with an eighth valve 201. The sample needle cleaning tank 302 is connected to the water separator 109 through tubing. This tubing has a third two-position three-way valve 301, and the other port of the third two-position three-way valve 301 is connected to the purified water container 104 through tubing. Similarly, the reagent dispensing pump 212 of the reagent dispensing unit is connected to the water separator 109, and the reagent needle cleaning tank 312 of the reagent dispensing unit is connected to the water separator 109. During reagent installation, a second pressure sensor 202 is installed between the sample dispensing pump 203 and the eighth valve 201, and between the reagent dispensing pump 212 and the ninth valve 211 of the reagent dispensing unit. These sensors are used to monitor the pipeline pressure and determine the dispensing pressure, thereby ensuring the accuracy of reagent and sample dispensing and avoiding carryover contamination caused by abnormal pressure.

[0030] In actual operation, one of the second pumps 106 provides purified water to the sample needle cleaning tank 302 and the reagent needle cleaning tank 312 via a water separator 109, while the other second pump 106 provides purified water to the reagent needle and sample needle 204 via the water separator 109, ensuring effective internal and external cleaning of the reagent needle and sample needle 204. In this invention, the sample dispensing unit and the reagent dispensing unit are independent of each other, and there are two (or more) reagent dispensing units, further improving the efficiency of sample dispensing and reagent dispensing for each sample, thereby improving the detection efficiency.

[0031] In addition, reagent needles and sample needles 204 often need to be cleaned after filling to avoid cross-contamination and pipeline blockage. During cleaning, the second pump 106, which is connected to the sample pool cleaning tank and reagent needle cleaning tank 312, is turned on, and the pressure of the outlet of the second pump 106 is adjusted by the second pressure regulating valve 107, so that some water flows back into the purified water container 104; another second pump 106 is turned on, and its pressure is adjusted to make some water flow back into the purified water container 104; taking the cleaning of sample needle 204 as an example, when sample needle 204 enters the sample needle cleaning tank 302 for cleaning, the eighth valve 201 is energized, and the pressurized water in the water separator 109 flows through the eighth valve 201 in sequence. The sample dispensing pump 203 and the sample needle 204 flow into the sample needle cleaning pool 302, achieving internal cleaning of the sample needle 204. During this process, the third two-position three-way valve 301 corresponding to the sample needle cleaning pool 302 is energized, allowing water to enter the sample needle cleaning pool 302, achieving external cleaning of the sample needle 204. In this utility model, the sample needle 204 and the reagent needle can be cleaned sequentially or simultaneously, achieving timely cleaning of the sample needle 204 and the reagent needle 214 after use, resulting in high cleaning efficiency and improving detection efficiency.

[0032] Combination Figure 1 As can be seen, to avoid cross-contamination between samples, the sample needle cleaning module of this utility model also includes an alkaline washing pipeline (the reagent dispensing unit does not require alkaline washing). The alkaline washing pipeline is connected to the sample needle cleaning pool 302 and the alkaline solution container 332. An alkaline washing pump 333 (which can be a diaphragm pump) is installed on the alkaline washing pipeline. Alkaline washing solution can be pumped into the sample needle cleaning pool 302 through the alkaline washing pipeline. Repeated aspiration of the sample needle 204 can perform internal cleaning, and rinsing of the outer wall of the sample needle 204 can achieve external cleaning, ensuring the cleaning effect of the sample needle 204 and avoiding cross-contamination between samples. In addition, the bottom of the sample needle cleaning pool 302 is connected to a third drain pump 916 through a pipeline. The third drain pump 916 is connected to the waste liquid container 902 to ensure rapid waste discharge. Because the samples may be contaminated or infectious, an alkaline wash is performed before washing the sample needle 204 with water. Specifically: the alkaline wash pump 333 is powered on, and the alkaline solution in the alkaline solution container 332 is injected into the sample needle cleaning pool 302. The sample needle 204 is then inserted into the sample needle cleaning pool 302 to perform the liquid aspiration action, and the inner and outer walls are soaked and cleaned with alkaline solution. In actual cleaning, alkaline solution cleaning can be performed first, followed by purified water cleaning, to ensure the cleaning effect of the sample needle 204.

[0033] Combination Figure 1-2As can be seen, the substrate dispensing unit has two first substrate containers 401, two second substrate containers 402, two substrate needles 403, and two substrate pumps 404. The substrate needles 403 and substrate pumps 404 are connected one-to-one, and each substrate needle 403 and substrate pump 404 has a tenth valve 405 between them. The two first substrate containers 401 are connected in parallel and to one of the substrate pumps 404, and the two second substrate containers 402 are connected in parallel and to the other substrate pump 404. Chemiluminescence immunoassay analyzers typically use two types of substrates, with each substrate having two substrate containers. This means that each substrate uses dual backups, and the two sets of substrates are used alternately to avoid test interruptions caused by substrate changes.

[0034] In actual installation, a liquid level sensor is installed in each first substrate container 401 and each second substrate container 402 to monitor the liquid level. When the liquid level is lower than the preset level, the staff is reminded to replenish the liquid in time. Alternatively, a weight sensor can be installed below the first substrate container 401 and the second substrate container 402 during actual installation. When the weight of the substrate container is lower than the preset value, the staff is reminded to replenish the liquid in time.

[0035] Combination Figure 1 and Figure 3 It is known that the washing solution mixing unit includes a first washing solution container 506, a second washing solution container 505, and two concentrate containers 501 for holding concentrated washing solution. The first washing solution container 506 is connected to the purified water container 104 through a pure water pipeline. A third pump 504 is installed on the pure water pipeline, and the third pump 504 provides power. The two concentrate containers 501 are connected to the inlet of the concentration pump 503 through a fourth two-position three-way valve 502. The connection between the concentration container and the concentration pump 503 is switched through the fourth two-position three-way valve 502. The outlet of the concentration pump 503 is connected to the first washing solution container 506, which pumps the concentrated washing solution into the first washing solution container 506 (a stirred container can be used). The concentrated washing solution and purified water can be mixed evenly in the first washing solution container 506. The first washing solution container 506 and the second washing solution container 505 are connected by a washing solution pipeline. A fourth pump 507 is installed on the washing solution pipeline. The diluted washing solution can enter the second washing solution container 505 through the fourth pump 507. The second washing solution container 505 is connected to the main washing solution pipeline of the magnetic bead cleaning unit.

[0036] Below the first washing solution container 506 and the second washing solution container 505, there is a liquid volume monitoring device (preferably a weight sensor) for monitoring the liquid volume. The weight sensor below the first washing solution container 506 can ensure the amount of washing solution and purified water added, ensuring accurate dilution of the washing solution. The weight sensor below the second washing solution container 505 is used to monitor the weight and replenish the washing solution in time when it is insufficient, so as to avoid instrument interruption due to insufficient washing solution.

[0037] This invention provides two washing solution containers: one for diluting and concentrating the washing solution, and the other for providing washing solution to the magnetic bead cleaning unit, ensuring continuous operation of the magnetic bead cleaning unit and improving detection efficiency. Of course, in actual installation, there can be one or two second washing solution containers 505 to provide sufficient washing solution for sample detection.

[0038] Combination Figure 1 , 3 It is understood that the magnetic bead cleaning unit includes a washing solution filling module and a washing solution suction module. The washing solution filling module has a first two-position three-way valve 601 at its main washing solution pipeline. The inlet of the first two-position three-way valve 601 is divided into two paths: one connected to the second washing solution container 505, and the other connected to the water distributor 109. The first two-position three-way valve 601 can switch between purified water and washing solution to meet the precise filling requirements of the washing solution and the purified water cleaning requirements of the magnetic bead filling module, avoiding the need for the magnetic bead filling module to... Blockage; the washing fluid filling module has multiple filling branches connected to the main washing fluid pipeline. Each filling branch includes a filling branch pipe, a second valve 602, a washing fluid filling pump 603, a third valve 604, and a cleaning needle 605, which are sequentially arranged on the filling branch pipe. The third valve 604 is a two-position three-way valve. One port of each third valve 604 is connected to the washing fluid discharge pipe. The outlet of the washing fluid discharge pipe is connected to the waste liquid container 902 of the waste liquid unit, and the washing fluid discharge pipe has a fourth valve 606. Multiple cleaning solution pumps 603 share a single motor, ensuring consistent cleaning across multiple filling branches. During cleaning solution filling, if there is no reaction vessel below a cleaning needle 605, the third valve 604 switches to a state connected to the cleaning solution discharge pipe, allowing the cleaning solution from that filling branch to be directly discharged into the waste liquid container 902, preventing leakage. The cleaning solution suction module has multiple suction branches, each including a suction needle 607 and a suction pump 608, and is connected to the waste liquid container 902. After each cleaning cycle, the suction needle 607 and suction pump 608 can be used to pump the cleaning waste liquid from the reaction vessel into the waste liquid container 902, ensuring normal cleaning of the magnetic beads within the reaction vessel.

[0039] Combination Figure 1 , 4 It can be seen that the waste liquid unit includes a first waste discharge unit and a second waste discharge unit. The second waste discharge unit has a waste liquid container 902 and a second discharge pump 917 connected to the waste liquid container 902. The waste liquid in the waste liquid container 902 can be pumped to a designated container in a timely manner using the second discharge pump 917.

[0040] The suction branches of the washing liquid suction module are all connected to the waste liquid container 902, so that the magnetic bead cleaning waste liquid is directly discharged into the waste liquid container 902; the washing liquid discharge pipe of the magnetic bead cleaning module is connected to the waste liquid container 902, so that the excess washing liquid in the filling branch can be directly discharged into the waste liquid container 902 during the filling process.

[0041] The liquid circuit system for the chemiluminescence immunoassay analyzer described in this utility model further includes a liquid aspiration unit, which includes a liquid aspiration needle 901 and a liquid aspiration pump 903 connected in sequence through pipelines. The outlet of the liquid aspiration pump 903 is connected to a waste liquid container 902, which can directly pump the waste liquid after testing into the waste liquid container 902, which is beneficial for solid-liquid separation. The condensate generated by the reagent tray 913 of the chemiluminescence immunoassay analyzer is connected to the waste liquid container 902 through a condensate pump 914. The first needle cleaning pool 609 of the magnetic bead cleaning unit is connected to the waste liquid container through a waste liquid pump 915 to realize waste discharge. The cleaning pool 610 of the magnetic bead cleaning unit is connected to the waste liquid container 902. There is a height difference between the two, and the waste is discharged by gravity.

[0042] Combination Figure 1 , 4 As can be seen, the first waste discharge unit of this utility model is a vacuum waste liquid discharge unit, which has a vacuum pump 904, a first negative pressure tank 905 and two second negative pressure tanks 906. The vacuum pump 904 is connected to the first negative pressure tank 905. The connecting pipeline between the first negative pressure tank 905 and each of the second negative pressure tanks 906 is equipped with a pressure regulating valve 907 and a fifth valve 908 for adjusting the pressure during the vacuuming process, ensuring that the pressure of each negative pressure tank can reach the preset pressure during vacuuming. Each second negative pressure tank 906 is connected to a balance pipe that communicates with the outside atmosphere. A sixth valve 912 is installed on the balance pipe to balance and stabilize the pressure between the negative pressure tank and the external environment, facilitating waste discharge operations. In actual installation, both the reagent needle cleaning pool 312 and the sample needle cleaning pool 302 are connected to each of the second negative pressure tanks 906 via waste liquid pipelines. This means that waste liquid can be discharged under negative pressure during the cleaning process. Each waste liquid pipeline is equipped with an eleventh valve 909. The lower part of the first negative pressure tank 905 and each of the second negative pressure tanks 906 is connected to a waste discharge branch, which is connected to the first discharge pump 911. Each waste discharge branch is equipped with a seventh valve 910. The first discharge pump 911 is used to pump the waste liquid in the negative pressure tank to a designated location. Since alkaline waste liquid will also be generated in the reagent needle cleaning pool 312, the bottom of the sample needle cleaning pool 302 is connected to a third discharge pump 916 via a pipeline. The third discharge pump 916 is connected to the waste liquid container 902. During the alkaline cleaning of the sample needle 204, the generated waste liquid can be directly discharged into the waste liquid container 902, realizing timely discharge of waste liquid.

[0043] The vacuum establishment process of the negative pressure tank is as follows: Start the vacuum pump 904, connect the first negative pressure tank 905 to the vacuum pump 904, and establish negative pressure first; energize the two fifth valves 908 to connect the two second negative pressure tanks 906 to the first negative pressure tank 905, establish negative pressure in the second negative pressure tanks 906, and adjust the pressure in each second negative pressure tank 906 through the pressure regulating valve 907 so that the pressure in the two second negative pressure tanks 906 is within the preset range.

[0044] In actual operation, the two second negative pressure tanks 906 can be used alternately to establish negative pressure (by opening the corresponding fifth valve 908 when establishing negative pressure), ensuring the continuous operation of the negative pressure system: taking the second negative pressure tank 906 on the left as being under negative pressure and the second negative pressure tank 906 on the right as being full, waste liquid enters the second negative pressure tank 906 on the left. At this time, the sixth valve 912 of the second negative pressure tank 906 on the right is energized, connecting it to the outside atmosphere. The first drain pump 911 is energized to extract the waste liquid from the second negative pressure tank 906. After the waste liquid is completely discharged, the corresponding sixth valve 912 is de-energized. During operation, the two second negative pressure tanks 906 are always at a low liquid level and alternately drain and vacuum, ensuring the continuous operation of the first waste discharge unit.

[0045] During testing, after the sample needle 204 is cleaned, the eleventh valve 909 corresponding to the sample needle cleaning tank 302 is energized, causing the waste liquid generated during cleaning to flow into the negative pressure tank for timely discharge. Furthermore, the sample needle cleaning tank 302 is also connected to the waste liquid container 902, meaning the sample cleaning tank is simultaneously connected to both the first and second waste discharge units. These two units are independent yet mutually supportive, reducing the risk of overflow from the sample needle cleaning tank 302 and lowering the instrument failure rate. The waste liquid unit of this invention comprises a first waste discharge unit and a second waste discharge unit. The second waste discharge unit uses a pump to draw waste liquid into the waste liquid container 902, while the first waste discharge unit uses vacuum discharge. The combination of these two units improves waste liquid discharge efficiency, thereby increasing the operating speed of this invention and meeting the needs of high-throughput instruments.

[0046] Finally, it should be emphasized that the above description is merely a preferred embodiment of this utility model and is not intended to limit this utility model. Although this utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still make modifications to the technical solutions described in the foregoing embodiments without creative effort, or make equivalent substitutions for some of the technical features. Therefore, any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this utility model should be included within the protection scope of this utility model.

Claims

1. A liquid circuit system for a chemiluminescence immunoassay analyzer, comprising a magnetic bead cleaning unit, a substrate dispensing unit, a water supply unit, and a waste liquid discharge unit, characterized in that: It also includes a sample dispensing unit, a reagent dispensing unit, and a washing solution mixing unit. The water supply unit includes a water supply pipeline, a purified water container connected to the water supply pipeline, and a water supply line. The water supply pipeline is sequentially equipped with a first pressure regulating valve, a first valve, and a first pump. The water supply line has at least two lines. The outlet of the second pump in each water supply line is split into two: one line is connected to a water distributor, and the other line has a second pressure regulating valve and flows back into the purified water container. The washing solution mixing unit includes a first washing solution container, a second washing solution container, and at least two concentrated solution containers for holding concentrated washing solution. The first washing solution container is connected to the purified water container via a pure water pipeline. A third pump is installed on the pure water pipeline. At least two of the concentrated solution containers are connected to the inlet of the concentrated pump, and the outlet of the concentrated pump is connected to the first washing solution container. The first washing solution container and the second washing solution container are connected via a washing solution pipeline, and a fourth pump is installed on the washing solution pipeline. A liquid level monitoring device for monitoring the liquid level is installed below or inside the purified water container, the first washing solution container, and the second washing solution container.

2. The liquid circuit system for a chemiluminescence immunoassay analyzer according to claim 1, characterized in that: The magnetic bead cleaning unit includes a cleaning solution filling module and a cleaning solution suction module. The cleaning solution filling module is equipped with a first two-position three-way valve at the main cleaning solution pipeline. The inlet of the first two-position three-way valve is divided into two paths, one of which is connected to the second cleaning solution container and the other of which is connected to the water distributor. The washing liquid filling module has multiple filling branches connected to the main washing liquid pipeline. Each filling branch includes a filling branch pipe, a second valve, a filling pump, and a third valve arranged sequentially on the filling branch pipe. The third valve is a two-position three-way valve. One port of each third valve is connected to the washing liquid discharge pipe. The outlet of the washing liquid discharge pipe is connected to the waste liquid container of the waste liquid unit, and the washing liquid discharge pipe has a fourth valve.

3. The liquid circuit system for a chemiluminescence immunoassay analyzer according to claim 2, characterized in that: The waste liquid unit includes a first waste discharge unit and a second waste discharge unit, wherein the second waste discharge unit has a waste liquid container and a second discharge pump connected to the waste liquid container; The first waste discharge unit is a vacuum waste liquid discharge unit, which has a vacuum pump, a first negative pressure tank and at least two second negative pressure tanks. The vacuum pump is connected to the first negative pressure tank. The connecting pipeline between the first negative pressure tank and each of the second negative pressure tanks is equipped with a pressure regulating valve and a fifth valve for adjusting the pressure. Each second negative pressure tank is connected to a balance pipe that communicates with the outside atmosphere. A sixth valve is provided on the balance pipe. The sample needle cleaning pool of the sample dispensing unit and the reagent needle cleaning pool of the reagent dispensing unit are connected to each second negative pressure tank via waste liquid pipelines; the lower part of the first negative pressure tank and each second negative pressure tank is connected to a waste discharge branch, which is connected to the first discharge pump, and each waste discharge branch is equipped with a seventh valve.

4. The liquid circuit system for a chemiluminescence immunoassay analyzer according to claim 3, characterized in that: Both the first negative pressure tank and the second negative pressure tank are equipped with liquid level sensors.

5. The liquid circuit system for a chemiluminescence immunoassay analyzer according to claim 3, characterized in that: The sample dispensing unit includes a sample dispensing module and a sample needle cleaning module. The sample needle cleaning module includes an alkaline solution container and an alkaline washing pipeline connected to the alkaline solution container. The alkaline washing pipeline is connected to the sample needle cleaning tank and is equipped with an alkaline washing pump. The bottom of the sample needle cleaning tank is connected to a third drain pump via a pipeline, and the third drain pump is connected to the waste liquid container.

6. The liquid circuit system for a chemiluminescence immunoassay analyzer according to claim 5, characterized in that: It also includes a liquid suction unit, which includes a liquid suction needle and a liquid suction pump connected in sequence through a pipeline, and the outlet of the liquid suction pump is connected to the waste liquid container.

7. The liquid circuit system for a chemiluminescence immunoassay analyzer according to claim 2, characterized in that: Each suction branch of the washing liquid suction module is connected to the waste liquid container.

8. The liquid circuit system for a chemiluminescence immunoassay analyzer according to claim 1, characterized in that: The substrate dispensing unit has a first substrate container and a second substrate container, wherein there are at least two first substrate containers and at least two second substrate containers.

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